Keywords
Last Name
Institution

Joseph A. Helpern

TitleEndowed Chair for Brain Imaging
InstitutionMedical University of South Carolina
DepartmentRadiology and Radiological Science
AddressP.O. Box 120
210
68 President St.
Phone843-876-2480
Fax843-876-2469
     awards and honors
    1977Citation for Outstanding Accomplishments, American Chemical Society
    1978 - 1979Research Assistantship, University of North Carolina, Chapel Hill
    1992 - 1993Shannon Award, National Institutes of Health
    2000Excellence in Research Award, New York State, Office of Mental Health
    2005Fellow (elected), International Society for Magnetic Resonance in Medicine
    2008Wyeth Research Lecturer, Temple University
    2012Distinguished Investigator, Academy of Radiology Research
    2013Distinguished Alumni Achievement Award, Oakland University
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Hui ES, Russell Glenn G, Helpern JA, Jensen JH. Kurtosis analysis of neural diffusion organization. Neuroimage. 2015 Feb 1; 106:391-403.
      View in: PubMed
    2. Lee CY, Tabesh A, Nesland T, Jensen JH, Helpern JA, Spampinato MV, Bonilha L. Human brain asymmetry in microstructural connectivity demonstrated by diffusional kurtosis imaging. Brain Res. 2014 Nov 7; 1588:73-80.
      View in: PubMed
    3. Adisetiyo V, Jensen JH, Tabesh A, Deardorff RL, Fieremans E, Di Martino A, Gray KM, Castellanos FX, Helpern JA. Multimodal MR imaging of brain iron in attention deficit hyperactivity disorder: a noninvasive biomarker that responds to psychostimulant treatment? Radiology. 2014 Aug; 272(2):524-32.
      View in: PubMed
    4. Falangola MF, Guilfoyle DN, Tabesh A, Hui ES, Nie X, Jensen JH, Gerum SV, Hu C, LaFrancois J, Collins HR, Helpern JA. Histological correlation of diffusional kurtosis and white matter modeling metrics in cuprizone-induced corpus callosum demyelination. NMR Biomed. 2014 Aug; 27(8):948-57.
      View in: PubMed
    5. Lee CY, Tabesh A, Spampinato MV, Helpern JA, Jensen JH, Bonilha L. Diffusional kurtosis imaging reveals a distinctive pattern of microstructural alternations in idiopathic generalized epilepsy. Acta Neurol Scand. 2014 Sep; 130(3):148-55.
      View in: PubMed
    6. Jensen JH, Helpern JA. In vivo characterization of brain iron with magnetic field correlation imaging. Future Neurol. 2014 May 1; 9(3):247-250.
      View in: PubMed
    7. Jensen JH, Hui ES, Helpern JA. Double-pulsed diffusional kurtosis imaging. NMR Biomed. 2014 Apr; 27(4):363-70.
      View in: PubMed
    8. Novikov DS, Jensen JH, Helpern JA, Fieremans E. Revealing mesoscopic structural universality with diffusion. Proc Natl Acad Sci U S A. 2014 Apr 8; 111(14):5088-93.
      View in: PubMed
    9. Jensen JH, Hui ES, Helpern JA. Double-pulsed diffusional kurtosis imaging. NMR Biomed. 2014 Feb 20.
      View in: PubMed
    10. Jensen JH, Helpern JA, Tabesh A. Leading non-Gaussian corrections for diffusion orientation distribution function. NMR Biomed. 2014 Feb; 27(2):202-11.
      View in: PubMed
    11. Paydar A, Fieremans E, Nwankwo JI, Lazar M, Sheth HD, Adisetiyo V, Helpern JA, Jensen JH, Milla SS. Diffusional kurtosis imaging of the developing brain. AJNR Am J Neuroradiol. 2014 Apr; 35(4):808-14.
      View in: PubMed
    12. Benitez A, Fieremans E, Jensen JH, Falangola MF, Tabesh A, Ferris SH, Helpern JA. White matter tract integrity metrics reflect the vulnerability of late-myelinating tracts in Alzheimer's disease. Neuroimage Clin. 2014; 4:64-71.
      View in: PubMed
    13. Faro SH, Mohamed FB, Helpern JA, Jensen JH, Thulborn KR, Atkinson IC, Sair HI, Mikulis DJ. Hot topics in functional neuroradiology. AJNR Am J Neuroradiol. 2013 Dec; 34(12):2241-9.
      View in: PubMed
    14. Bonilha L, Helpern JA, Sainju R, Nesland T, Edwards JC, Glazier SS, Tabesh A. Presurgical connectome and postsurgical seizure control in temporal lobe epilepsy. Neurology. 2013 Nov 5; 81(19):1704-10.
      View in: PubMed
    15. Lee CY, Tabesh A, Benitez A, Helpern JA, Jensen JH, Bonilha L. Microstructural integrity of early- versus late-myelinating white matter tracts in medial temporal lobe epilepsy. Epilepsia. 2013 Oct; 54(10):1801-9.
      View in: PubMed
    16. Adisetiyo V, Tabesh A, Di Martino A, Falangola MF, Castellanos FX, Jensen JH, Helpern JA. Attention-deficit/hyperactivity disorder without comorbidity is associated with distinct atypical patterns of cerebral microstructural development. Hum Brain Mapp. 2014 May; 35(5):2148-62.
      View in: PubMed
    17. Fieremans E, Benitez A, Jensen JH, Falangola MF, Tabesh A, Deardorff RL, Spampinato MV, Babb JS, Novikov DS, Ferris SH, Helpern JA. Novel white matter tract integrity metrics sensitive to Alzheimer disease progression. AJNR Am J Neuroradiol. 2013 Nov-Dec; 34(11):2105-12.
      View in: PubMed
    18. Falangola MF, Jensen JH, Tabesh A, Hu C, Deardorff RL, Babb JS, Ferris S, Helpern JA. Non-Gaussian diffusion MRI assessment of brain microstructure in mild cognitive impairment and Alzheimer's disease. Magn Reson Imaging. 2013 Jul; 31(6):840-6.
      View in: PubMed
    19. Raz E, Bester M, Sigmund EE, Tabesh A, Babb JS, Jaggi H, Helpern J, Mitnick RJ, Inglese M. A better characterization of spinal cord damage in multiple sclerosis: a diffusional kurtosis imaging study. AJNR Am J Neuroradiol. 2013 Sep; 34(9):1846-52.
      View in: PubMed
    20. Yang AW, Jensen JH, Hu CC, Tabesh A, Falangola MF, Helpern JA. Effect of cerebral spinal fluid suppression for diffusional kurtosis imaging. J Magn Reson Imaging. 2013 Feb; 37(2):365-71.
      View in: PubMed
    21. Hui ES, Fieremans E, Jensen JH, Tabesh A, Feng W, Bonilha L, Spampinato MV, Adams R, Helpern JA. Stroke assessment with diffusional kurtosis imaging. Stroke. 2012 Nov; 43(11):2968-73.
      View in: PubMed
    22. Adisetiyo V, Jensen JH, Ramani A, Tabesh A, Di Martino A, Fieremans E, Castellanos FX, Helpern JA. In vivo assessment of age-related brain iron differences by magnetic field correlation imaging. J Magn Reson Imaging. 2012 Aug; 36(2):322-31.
      View in: PubMed
    23. Sigmund EE, Suero GA, Hu C, McGorty K, Sodickson DK, Wiggins GC, Helpern JA. High-resolution human cervical spinal cord imaging at 7?T. NMR Biomed. 2012 Jul; 25(7):891-9.
      View in: PubMed
    24. Fieremans E, Jensen JH, Helpern JA. White matter characterization with diffusional kurtosis imaging. Neuroimage. 2011 Sep 1; 58(1):177-88.
      View in: PubMed
    25. Novikov DS, Fieremans E, Jensen JH, Helpern JA. Random walk with barriers. Nat Phys. 2011 Jun 1; 7(6):508-514.
      View in: PubMed
    26. Jiang Q, Qu C, Chopp M, Ding GL, Davarani SP, Helpern JA, Jensen JH, Zhang ZG, Li L, Lu M, Kaplan D, Hu J, Shen Y, Kou Z, Li Q, Wang S, Mahmood A. MRI evaluation of axonal reorganization after bone marrow stromal cell treatment of traumatic brain injury. NMR Biomed. 2011 Nov; 24(9):1119-28.
      View in: PubMed
    27. Jensen JH, Helpern JA. Effect of gradient pulse duration on MRI estimation of the diffusional kurtosis for a two-compartment exchange model. J Magn Reson. 2011 Jun; 210(2):233-7.
      View in: PubMed
    28. Helpern JA, Adisetiyo V, Falangola MF, Hu C, Di Martino A, Williams K, Castellanos FX, Jensen JH. Preliminary evidence of altered gray and white matter microstructural development in the frontal lobe of adolescents with attention-deficit hyperactivity disorder: a diffusional kurtosis imaging study. J Magn Reson Imaging. 2011 Jan; 33(1):17-23.
      View in: PubMed
    29. Tabesh A, Jensen JH, Ardekani BA, Helpern JA. Estimation of tensors and tensor-derived measures in diffusional kurtosis imaging. Magn Reson Med. 2011 Mar; 65(3):823-36.
      View in: PubMed
    30. Jensen JH, Falangola MF, Hu C, Tabesh A, Rapalino O, Lo C, Helpern JA. Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction. NMR Biomed. 2011 Jun; 24(5):452-7.
      View in: PubMed
    31. Jensen JH, Helpern JA. Progress in diffusion-weighted imaging: concepts, techniques and applications to the central nervous system. NMR Biomed. 2010 Aug; 23(7):659-60.
      View in: PubMed
    32. Jensen JH, Helpern JA. MRI quantification of non-Gaussian water diffusion by kurtosis analysis. NMR Biomed. 2010 Aug; 23(7):698-710.
      View in: PubMed
    33. Fieremans E, Novikov DS, Jensen JH, Helpern JA. Monte Carlo study of a two-compartment exchange model of diffusion. NMR Biomed. 2010 Aug; 23(7):711-24.
      View in: PubMed
    34. Jensen JH, Szulc K, Hu C, Ramani A, Lu H, Xuan L, Falangola MF, Chandra R, Knopp EA, Schenck J, Zimmerman EA, Helpern JA. Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain. Magn Reson Med. 2009 Feb; 61(2):481-5.
      View in: PubMed
    35. Cheung MM, Hui ES, Chan KC, Helpern JA, Qi L, Wu EX. Does diffusion kurtosis imaging lead to better neural tissue characterization? A rodent brain maturation study. Neuroimage. 2009 Apr 1; 45(2):386-92.
      View in: PubMed
    36. Falangola MF, Jensen JH, Babb JS, Hu C, Castellanos FX, Di Martino A, Ferris SH, Helpern JA. Age-related non-Gaussian diffusion patterns in the prefrontal brain. J Magn Reson Imaging. 2008 Dec; 28(6):1345-50.
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    37. Lazar M, Jensen JH, Xuan L, Helpern JA. Estimation of the orientation distribution function from diffusional kurtosis imaging. Magn Reson Med. 2008 Oct; 60(4):774-81.
      View in: PubMed
    38. Lu H, Law M, Ge Y, Hesseltine SM, Rapalino O, Jensen JH, Helpern JA. Quantitative measurement of spinal cord blood volume in humans using vascular-space-occupancy MRI. NMR Biomed. 2008 Mar; 21(3):226-32.
      View in: PubMed
    39. Lu H, Pollack E, Young R, Babb JS, Johnson G, Zagzag D, Carson R, Jensen JH, Helpern JA, Law M. Predicting grade of cerebral glioma using vascular-space occupancy MR imaging. AJNR Am J Neuroradiol. 2008 Feb; 29(2):373-8.
      View in: PubMed
    40. Ge Y, Jensen JH, Lu H, Helpern JA, Miles L, Inglese M, Babb JS, Herbert J, Grossman RI. Quantitative assessment of iron accumulation in the deep gray matter of multiple sclerosis by magnetic field correlation imaging. AJNR Am J Neuroradiol. 2007 Oct; 28(9):1639-44.
      View in: PubMed
    41. Falangola MF, Dyakin VV, Lee SP, Bogart A, Babb JS, Duff K, Nixon R, Helpern JA. Quantitative MRI reveals aging-associated T2 changes in mouse models of Alzheimer's disease. NMR Biomed. 2007 May; 20(3):343-51.
      View in: PubMed
    42. Ramani A, Jensen JH, Helpern JA. Quantitative MR imaging in Alzheimer disease. Radiology. 2006 Oct; 241(1):26-44.
      View in: PubMed
    43. Jensen JH, Chandra R, Ramani A, Lu H, Johnson G, Lee SP, Kaczynski K, Helpern JA. Magnetic field correlation imaging. Magn Reson Med. 2006 Jun; 55(6):1350-61.
      View in: PubMed
    44. Lu H, Jensen JH, Ramani A, Helpern JA. Three-dimensional characterization of non-gaussian water diffusion in humans using diffusion kurtosis imaging. NMR Biomed. 2006 Apr; 19(2):236-47.
      View in: PubMed
    45. Lu H, Law M, Johnson G, Ge Y, van Zijl PC, Helpern JA. Novel approach to the measurement of absolute cerebral blood volume using vascular-space-occupancy magnetic resonance imaging. Magn Reson Med. 2005 Dec; 54(6):1403-11.
      View in: PubMed
    46. Jensen JH, Helpern JA, Ramani A, Lu H, Kaczynski K. Diffusional kurtosis imaging: the quantification of non-gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med. 2005 Jun; 53(6):1432-40.
      View in: PubMed
    47. Falangola MF, Lee SP, Nixon RA, Duff K, Helpern JA. Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice. Neurochem Res. 2005 Feb; 30(2):201-5.
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    48. Falangola MF, Ardekani BA, Lee SP, Babb JS, Bogart A, Dyakin VV, Nixon R, Duff K, Helpern JA. Application of a non-linear image registration algorithm to quantitative analysis of T2 relaxation time in transgenic mouse models of AD pathology. J Neurosci Methods. 2005 May 15; 144(1):91-7.
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    49. Jensen JH, Helpern JA. Iron-fortified MRI: effects and applications of iron-induced NMR relaxation in biological tissues. NMR Biomed. 2004 Nov; 17(7):425-6.
      View in: PubMed
    50. Lee SP, Falangola MF, Nixon RA, Duff K, Helpern JA. Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents. Magn Reson Med. 2004 Sep; 52(3):538-44.
      View in: PubMed
    51. Helpern JA, Lee SP, Falangola MF, Dyakin VV, Bogart A, Ardekani B, Duff K, Branch C, Wisniewski T, de Leon MJ, Wolf O, O'Shea J, Nixon RA. MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease. Magn Reson Med. 2004 Apr; 51(4):794-8.
      View in: PubMed
    52. Helpern JA, Jensen J, Lee SP, Falangola MF. Quantitative MRI assessment of Alzheimer's disease. J Mol Neurosci. 2004; 24(1):45-8.
      View in: PubMed
    53. Helpern JA. The promise of high-field-strength MR imaging. AJNR Am J Neuroradiol. 2003 Oct; 24(9):1738-9.
      View in: PubMed
    54. Choi IY, Lee SP, Guilfoyle DN, Helpern JA. In vivo NMR studies of neurodegenerative diseases in transgenic and rodent models. Neurochem Res. 2003 Jul; 28(7):987-1001.
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    55. Guilfoyle DN, Helpern JA, Lim KO. Diffusion tensor imaging in fixed brain tissue at 7.0 T. NMR Biomed. 2003 Apr; 16(2):77-81.
      View in: PubMed
    56. Guilfoyle DN, Dyakin VV, O'Shea J, Pell GS, Helpern JA. Quantitative measurements of proton spin-lattice (T1) and spin-spin (T2) relaxation times in the mouse brain at 7.0 T. Magn Reson Med. 2003 Mar; 49(3):576-80.
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    57. Peshkovsky A, Knuth KH, Helpern JA. Motion correction in MRI using an apparatus for dynamic angular position tracking (ADAPT). Magn Reson Med. 2003 Jan; 49(1):138-43.
      View in: PubMed
    58. Lim KO, Helpern JA. Neuropsychiatric applications of DTI - a review. NMR Biomed. 2002 Nov-Dec; 15(7-8):587-93.
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    59. Ardekani BA, Choi SJ, Hossein-Zadeh GA, Porjesz B, Tanabe JL, Lim KO, Bilder R, Helpern JA, Begleiter H. Functional magnetic resonance imaging of brain activity in the visual oddball task. Brain Res Cogn Brain Res. 2002 Nov; 14(3):347-56.
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    60. Ardekani BA, Bachman AH, Helpern JA. A quantitative comparison of motion detection algorithms in fMRI. Magn Reson Imaging. 2001 Sep; 19(7):959-63.
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    61. Helpern JA. The missing element. AJNR Am J Neuroradiol. 2001 Aug; 22(7):1235-6.
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    62. Lipton ML, Branch CA, Hrabe J, Lewis DP, Helpern JA. RF excitation profiles with FAIR: impact of truncation of the arterial input function on quantitative perfusion. J Magn Reson Imaging. 2001 Feb; 13(2):207-14.
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    63. Tanabe JL, Yongbi M, Branch C, Hrabe J, Johnson G, Helpern JA. MR perfusion imaging in human brain using the UNFAIR technique. Un-inverted flow-sensitive alternating inversion recovery. J Magn Reson Imaging. 1999 Jun; 9(6):761-7.
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    64. Branch CA, Hernandez L, Yongbi M, Huang NC, Helpern JA. Rapid and continuous monitoring of cerebral perfusion by magnetic resonance line scan assessment with arterial spin tagging. NMR Biomed. 1999 Feb; 12(1):15-25.
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    65. Yongbi MN, Branch CA, Helpern JA. Perfusion imaging using FOCI RF pulses. Magn Reson Med. 1998 Dec; 40(6):938-43.
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    66. Huang NC, Yongbi MN, Helpern JA. The influence of preischemic hyperglycemia on acute changes in brain water ADCw following focal ischemia in rats. Brain Res. 1998 Mar 30; 788(1-2):137-43.
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    67. Huang NC, Yongbi MN, Helpern JA. The influence of preischemic hyperglycemia on acute changes in the apparent diffusion coefficient of brain water following global ischemia in rats. Brain Res. 1997 May 16; 757(1):139-45.
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    68. Yongbi MN, Huang NC, Branch CA, Helpern JA. The application of diffusion-weighted line-scanning for the rapid assessment of water ADC changes in stroke at high magnetic fields. NMR Biomed. 1997 Apr; 10(2):79-86.
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    69. Helpern JA, Branch CA, Yongbi MN, Huang NC. Perfusion imaging by un-inverted flow-sensitive alternating inversion recovery (UNFAIR). Magn Reson Imaging. 1997; 15(2):135-9.
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    70. Kao W, Helpern JA, Goldstein S, Gheorghiade M, Levine B. Abnormalities of skeletal muscle metabolism during nerve stimulation determined by 31P nuclear magnetic resonance spectroscopy in severe congestive heart failure. Am J Cardiol. 1995 Sep 15; 76(8):606-9.
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    71. Gorell JM, Ordidge RJ, Brown GG, Deniau JC, Buderer NM, Helpern JA. Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease. Neurology. 1995 Jun; 45(6):1138-43.
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    72. Helpern JA, Ordidge RJ, Gorell JM, Deniau JC, Welch KM. Preliminary observations of transverse relaxation rates obtained at 3 tesla from the substantia nigra of adult normal human brain. NMR Biomed. 1995 Feb; 8(1):25-7.
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    73. Helpern JA, Huang N. Diffusion-weighted imaging in epilepsy. Magn Reson Imaging. 1995; 13(8):1227-31.
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    74. Ordidge RJ, Gorell JM, Deniau JC, Knight RA, Helpern JA. Assessment of relative brain iron concentrations using T2-weighted and T2*-weighted MRI at 3 Tesla. Magn Reson Med. 1994 Sep; 32(3):335-41.
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    75. Jiang Q, Chopp M, Zhang ZG, Helpern JA, Ordidge RJ, Ewing J, Jiang P, Marchese BA. The effect of hypothermia on transient focal ischemia in rat brain evaluated by diffusion- and perfusion-weighted NMR imaging. J Cereb Blood Flow Metab. 1994 Sep; 14(5):732-41.
      View in: PubMed
    76. Knight RA, Dereski MO, Helpern JA, Ordidge RJ, Chopp M. Magnetic resonance imaging assessment of evolving focal cerebral ischemia. Comparison with histopathology in rats. Stroke. 1994 Jun; 25(6):1252-61; discussion 1261-2.
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    77. Ordidge RJ, Helpern JA, Qing ZX, Knight RA, Nagesh V. Correction of motional artifacts in diffusion-weighted MR images using navigator echoes. Magn Reson Imaging. 1994; 12(3):455-60.
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    78. Ordidge RJ, Knight RA, Helpern JA, Hugg JW. A low flip angle spin-echo technique for producing rapid diffusion weighted MR images. Magn Reson Imaging. 1994; 12(5):727-31.
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    79. Jiang Q, Zhang ZG, Chopp M, Helpern JA, Ordidge RJ, Garcia JH, Marchese BA, Qing ZX, Knight RA. Temporal evolution and spatial distribution of the diffusion constant of water in rat brain after transient middle cerebral artery occlusion. J Neurol Sci. 1993 Dec 15; 120(2):123-30.
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    80. Helpern JA, Vande Linde AM, Welch KM, Levine SR, Schultz LR, Ordidge RJ, Halvorson HR, Hugg JW. Acute elevation and recovery of intracellular [Mg2+] following human focal cerebral ischemia. Neurology. 1993 Aug; 43(8):1577-81.
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    81. Brown GG, Garcia JH, Gdowski JW, Levine SR, Helpern JA. Altered brain energy metabolism in demented patients with multiple subcortical ischemic lesions. Working hypotheses. Arch Neurol. 1993 Apr; 50(4):384-8.
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    82. Ewing JR, Warner R, Helpern JA. A cylindrically symmetric magnetic shield for a large-bore 3.0 Tesla magnet. Magn Reson Med. 1993 Mar; 29(3):398-401.
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    83. Helpern JA, Dereski MO, Knight RA, Ordidge RJ, Chopp M, Qing ZX. Histopathological correlations of nuclear magnetic resonance imaging parameters in experimental cerebral ischemia. Magn Reson Imaging. 1993; 11(2):241-6.
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    84. Levine SR, Helpern JA, Welch KM, Vande Linde AM, Sawaya KL, Brown EE, Ramadan NM, Deveshwar RK, Ordidge RJ. Human focal cerebral ischemia: evaluation of brain pH and energy metabolism with P-31 NMR spectroscopy. Radiology. 1992 Nov; 185(2):537-44.
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    85. Branch CA, Ewing JR, Helpern JA, Ordidge RJ, Butt S, Welch KM. Atraumatic quantitation of cerebral perfusion in cats by 19F magnetic resonance imaging. Magn Reson Med. 1992 Nov; 28(1):39-53.
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    86. Halvorson HR, Vande Linde AM, Helpern JA, Welch KM. Assessment of magnesium concentrations by 31P NMR in vivo. NMR Biomed. 1992 Mar-Apr; 5(2):53-8.
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    87. Welch KM, Levine SR, Martin G, Ordidge R, Vande Linde AM, Helpern JA. Magnetic resonance spectroscopy in cerebral ischemia. Neurol Clin. 1992 Feb; 10(1):1-29.
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    88. Vande Linde AM, Chopp M, Chen H, Helpern JA, Knight R, Schultz L, Welch KM. Chronic changes in the brain Mg2+ concentration after forebrain ischemia in the rat. Metab Brain Dis. 1991 Dec; 6(4):199-206.
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    89. Jiang Q, Knight RA, Chopp M, Helpern JA, Ordidge RJ, Qing ZX, Hetzel FW. 1H magnetic resonance imaging of normal brain tissue response to photodynamic therapy. Neurosurgery. 1991 Oct; 29(4):538-46.
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    90. Branch CA, Helpern JA, Ewing JR, Welch KM. 19F NMR imaging of cerebral blood flow. Magn Reson Med. 1991 Jul; 20(1):151-7.
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    91. Knight RA, Ordidge RJ, Helpern JA, Chopp M, Rodolosi LC, Peck D. Temporal evolution of ischemic damage in rat brain measured by proton nuclear magnetic resonance imaging. Stroke. 1991 Jun; 22(6):802-8.
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    92. Martin GB, Paradis NA, Helpern JA, Nowak RM, Welch KM. Nuclear magnetic resonance spectroscopy study of human brain after cardiac resuscitation. Stroke. 1991 Apr; 22(4):462-8.
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    93. Ordidge RJ, Helpern JA, Knight RA, Qing ZX, Welch KM. Investigation of cerebral ischemia using magnetization transfer contrast (MTC) MR imaging. Magn Reson Imaging. 1991; 9(6):895-902.
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    94. Ordidge RJ, Knight RA, Helpern JA. Magnetization transfer contrast (MTC) in flash MR imaging. Magn Reson Imaging. 1991; 9(6):889-93.
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    95. Chopp M, Vande Linde AM, Chen H, Knight R, Helpern JA, Welch KM. Chronic cerebral intracellular alkalosis following forebrain ischemic insult in rats. Stroke. 1990 Mar; 21(3):463-6.
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    96. Welch KM, Levine SR, Helpern JA. Pathophysiological correlates of cerebral ischemia the significance of cellular acid base shifts. Funct Neurol. 1990 Jan-Mar; 5(1):21-31.
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    97. Ewing JR, Branch CA, Fagan SC, Helpern JA, Simkins RT, Butt SM, Welch KM. Fluorocarbon-23 measure of cat cerebral blood flow by nuclear magnetic resonance. Stroke. 1990 Jan; 21(1):100-6.
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    98. Brown GG, Levine SR, Gorell JM, Pettegrew JW, Gdowski JW, Bueri JA, Helpern JA, Welch KM. In vivo 31P NMR profiles of Alzheimer's disease and multiple subcortical infarct dementia. Neurology. 1989 Nov; 39(11):1423-7.
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    99. Ramadan NM, Halvorson H, Vande-Linde A, Levine SR, Helpern JA, Welch KM. Low brain magnesium in migraine. Headache. 1989 Oct; 29(9):590-3.
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    100. Chopp M, Tidwell CD, Lee YJ, Knight R, Helpern JA, Welch KM. Reduction of hyperthermic ischemic acidosis by a conditioning event in cats. Stroke. 1989 Oct; 20(10):1357-60.
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    101. Ramadan NM, Halvorson H, Vande-Linde A, Levine SR, Helpern JA, Welch KM. Low brain magnesium in migraine. Headache. 1989 Jul; 29(7):416-9.
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    102. Helpern JA, Welch KM, Halvorson HR. Rubidium transport in human erythrocyte suspensions monitored by 87Rb NMR with aqueous chemical shift reagents. NMR Biomed. 1989 Jul; 2(2):47-54.
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    103. Helpern JA, Kao W, Gross B, Kensora TG, Welch KM. Interleaved 31P NMR with transcutaneous nerve stimulation (TNS): a method of monitoring compliance-independent skeletal muscle metabolic response to exercise. Magn Reson Med. 1989 Apr; 10(1):50-6.
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    104. Chopp M, Knight R, Tidwell CD, Helpern JA, Brown E, Welch KM. The metabolic effects of mild hypothermia on global cerebral ischemia and recirculation in the cat: comparison to normothermia and hyperthermia. J Cereb Blood Flow Metab. 1989 Apr; 9(2):141-8.
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    105. Welch KM, Levine SR, D'Andrea G, Schultz LR, Helpern JA. Preliminary observations on brain energy metabolism in migraine studied by in vivo phosphorus 31 NMR spectroscopy. Neurology. 1989 Apr; 39(4):538-41.
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    106. Ewing JR, Branch CA, Helpern JA, Smith MB, Butt SM, Welch KM. Cerebral blood flow measured by NMR indicator dilution in cats. Stroke. 1989 Feb; 20(2):259-67.
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    107. Chopp M, Welch KM, Tidwell CD, Knight R, Helpern JA. Effect of mild hyperthermia on recovery of metabolic function after global cerebral ischemia in cats. Stroke. 1988 Dec; 19(12):1521-5.
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    108. Welch KM, Levine SR, D'Andrea G, Helpern JA. Brain pH in migraine: an in vivo phosphorus-31 magnetic resonance spectroscopy study. Cephalalgia. 1988 Dec; 8(4):273-7.
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    109. Chopp M, Welch KM, Tidwell CD, Helpern JA. Global cerebral ischemia and intracellular pH during hyperglycemia and hypoglycemia in cats. Stroke. 1988 Nov; 19(11):1383-7.
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    110. Levine SR, Welch KM, Helpern JA, Chopp M, Bruce R, Selwa J, Smith MB. Prolonged deterioration of ischemic brain energy metabolism and acidosis associated with hyperglycemia: human cerebral infarction studied by serial 31P NMR spectroscopy. Ann Neurol. 1988 Apr; 23(4):416-8.
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    111. Helpern JA, Curtis JC, Hearshen D, Smith MB, Welch KM. The development of a pH-sensitive contrast agent for NMR 1H imaging. Magn Reson Med. 1987 Sep; 5(3):302-5.
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    112. Stein PD, Goldstein S, Sabbah HN, Liu ZQ, Helpern JA, Ewing JR, Lakier JB, Chopp M, LaPenna WF, Welch KM. In vivo evaluation of intracellular pH and high-energy phosphate metabolites during regional myocardial ischemia in cats using 31P nuclear magnetic resonance. Magn Reson Med. 1986 Apr; 3(2):262-9.
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    113. Welch KM, Helpern JA, Ewing JR, Robertson WM, D'Andrea G. Biochemical effects of cerebral ischemia: relevance to migraine. Cephalalgia. 1985 May; 5 Suppl 2:35-42.
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    114. Chopp M, Helpern JA, Frinak S, Hetzel FW, Ewing JR, Welch KM. In vivo 31-P NMR of photoactivated hematoporphyrin derivative in cat brain. Med Phys. 1985 Mar-Apr; 12(2):256-8.
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    115. Chopp M, Helpern JA, Ewing JR, Welch KM. Anoxia followed by hyperoxia: in vivo 31-P NMR of cat brain. Magn Reson Imaging. 1984; 2(4):329-33.
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    116. Helpern JA, McGee SJ, Riddle JM. Observations suggesting a possible link between gammacarboxyglutamic acid and porcine bioprosthetic valve calcification. Henry Ford Hosp Med J. 1982; 30(3):152-5.
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