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Gerard T. Hardiman

Title
InstitutionMedical University of South Carolina
DepartmentMedicine
AddressP.O. Box MSC 835
Suite 303
Cannon Place - 135 Cannon St.
Phone843-792-0771
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    Collapse Overview 
    Collapse overview
    Research interests include high through put genomics, comparative and systems biology, endocrine disruptors, cystic fibrosis and pharmacogenomics.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Maradonna F, Nozzi V, Dalla Valle L, Traversi I, Gioacchini G, Benato F, Colletti E, Gallo P, Di Marco Pisciottano I, Mita DG, Hardiman G, Mandich A, Carnevali O. A developmental hepatotoxicity study of dietary bisphenol A in Sparus aurata juveniles. Comp Biochem Physiol C Toxicol Pharmacol. 2014 Nov; 166:1-13. PMID: 24981242.
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    2. Baker ME, Hardiman G. Transcriptional analysis of endocrine disruption using zebrafish and massively parallel sequencing. J Mol Endocrinol. 2014 Jun; 52(3):R241-56. PMID: 24850832.
      View in: PubMed
    3. Carrion K, Dyo J, Patel V, Sasik R, Mohamed SA, Hardiman G, Nigam V. The long non-coding HOTAIR is modulated by cyclic stretch and WNT/ß-CATENIN in human aortic valve cells and is a novel repressor of calcification genes. PLoS One. 2014; 9(5):e96577. PMID: 24788418.
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    4. Paolini P, Pick D, Lapira J, Sannino G, Pasqualini L, Ludka C, Sprague LJ, Zhang X, Bartolotta EA, Vazquez-Hidalgo E, Barba DT, Bazan C, Hardiman G. Developmental and extracellular matrix-remodeling processes in rosiglitazone-exposed neonatal rat cardiomyocytes. Pharmacogenomics. 2014 Apr; 15(6):759-74. PMID: 24897284.
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    5. Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T. Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia. Nat Genet. 2014 Mar; 46(3):245-52. PMID: 24487275.
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    6. Vidal-Dorsch DE, Bay SM, Greenstein DJ, Baker ME, Hardiman G, Reyes JA, Kelley KM, Schlenk D. Biological responses of marine flatfish exposed to municipal wastewater effluent. Environ Toxicol Chem. 2014 Mar; 33(3):583-91. PMID: 24273037.
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    7. Baker ME, Vidal-Dorsch DE, Ribecco C, Sprague LJ, Angert M, Lekmine N, Ludka C, Martella A, Ricciardelli E, Bay SM, Gully JR, Kelley KM, Schlenk D, Carnevali O, Šášik R, Hardiman G. Molecular analysis of endocrine disruption in hornyhead turbot at wastewater outfalls in southern california using a second generation multi-species microarray. PLoS One. 2013; 8(9):e75553. PMID: 24086568.
      View in: PubMed
    8. Kozak I, Sasik R, Freeman WR, Sprague LJ, Gomez ML, Cheng L, El-Emam S, Mojana F, Bartsch DU, Bosten J, Ayyagari R, Hardiman G. A degenerative retinal process in HIV-associated non-infectious retinopathy. PLoS One. 2013; 8(9):e74712. PMID: 24069333.
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    9. Diaferia GR, Jimenez-Caliani AJ, Ranjitkar P, Yang W, Hardiman G, Rhodes CJ, Crisa L, Cirulli V. ß1 integrin is a crucial regulator of pancreatic ß-cell expansion. Development. 2013 Aug; 140(16):3360-72. PMID: 23863477.
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    10. Vidal-Dorsch DE, Bay SM, Ribecco C, Sprague LJ, Angert M, Ludka C, Ricciardelli E, Carnevali O, Greenstein DJ, Schlenk D, Kelley KM, Reyes JA, Snyder S, Vanderford B, Wiborg LC, Petschauer D, Sasik R, Baker M, Hardiman G. Genomic and phenotypic response of hornyhead turbot exposed to municipal wastewater effluents. Aquat Toxicol. 2013 Sep 15; 140-141:174-84. PMID: 23796538.
      View in: PubMed
    11. Patterson RA, Juarez MT, Hermann A, Sasik R, Hardiman G, McGinnis W. Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila. PLoS One. 2013; 8(4):e61773. PMID: 23637905.
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    12. Hardiman G. Next-generation antibody discovery platforms. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18245-6. PMID: 23093674.
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    13. Reyes JA, Vidal-Dorsch DE, Schlenk D, Bay SM, Armstrong JL, Gully JR, Cash C, Baker M, Stebbins TD, Hardiman G, Kelley KM. Evaluation of reproductive endocrine status in hornyhead turbot sampled from Southern California's urbanized coastal environments. Environ Toxicol Chem. 2012 Dec; 31(12):2689-700. PMID: 22987624.
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    14. Gioacchini G, Giorgini E, Merrifield DL, Hardiman G, Borini A, Vaccari L, Carnevali O. Probiotics can induce follicle maturational competence: the Danio rerio case. Biol Reprod. 2012 Mar; 86(3):65. PMID: 22088919.
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    15. Trachtenberg AJ, Robert JH, Abdalla AE, Fraser A, He SY, Lacy JN, Rivas-Morello C, Truong A, Hardiman G, Ohno-Machado L, Liu F, Hovig E, Kuo WP. A primer on the current state of microarray technologies. Methods Mol Biol. 2012; 802:3-17. PMID: 22130870.
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    16. Ribecco C, Hardiman G, Sášik R, Vittori S, Carnevali O. Teleost fish (Solea solea): a novel model for ecotoxicological assay of contaminated sediments. Aquat Toxicol. 2012 Mar; 109:133-42. PMID: 22217502.
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    17. Escoubet-Lozach L, Benner C, Kaikkonen MU, Lozach J, Heinz S, Spann NJ, Crotti A, Stender J, Ghisletti S, Reichart D, Cheng CS, Luna R, Ludka C, Sasik R, Garcia-Bassets I, Hoffmann A, Subramaniam S, Hardiman G, Rosenfeld MG, Glass CK. Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. PLoS Genet. 2011 Dec; 7(12):e1002401. PMID: 22174696.
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    18. Hardiman G. Genomic variation in the mouse. Pharmacogenomics. 2011 Dec; 12(12):1638-9. PMID: 22224210.
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    19. Hardiman G. Structural variation in the mouse genome. Pharmacogenomics. 2011 Dec; 12(12):1639. PMID: 22224211.
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    20. Hardiman G. The genetic basis of metabolic individuality in humans. Pharmacogenomics. 2011 Dec; 12(12):1637-8. PMID: 22118050.
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    21. Yebra M, Diaferia GR, Montgomery AM, Kaido T, Brunken WJ, Koch M, Hardiman G, Crisa L, Cirulli V. Endothelium-derived Netrin-4 supports pancreatic epithelial cell adhesion and differentiation through integrins a2ß1 and a3ß1. PLoS One. 2011; 6(7):e22750. PMID: 21829502.
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    22. Chen X, Li L, Cheng J, Chan LL, Wang DZ, Wang KJ, Baker ME, Hardiman G, Schlenk D, Cheng SH. Molecular staging of marine medaka: a model organism for marine ecotoxicity study. Mar Pollut Bull. 2011; 63(5-12):309-17. PMID: 21708389.
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    23. Ribecco C, Baker ME, Šášik R, Zuo Y, Hardiman G, Carnevali O. Biological effects of marine contaminated sediments on Sparus aurata juveniles. Aquat Toxicol. 2011 Aug; 104(3-4):308-16. PMID: 21658360.
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    24. Greenwood TA, Lazzeroni LC, Murray SS, Cadenhead KS, Calkins ME, Dobie DJ, Green MF, Gur RE, Gur RC, Hardiman G, Kelsoe JR, Leonard S, Light GA, Nuechterlein KH, Olincy A, Radant AD, Schork NJ, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Freedman R, Braff DL. Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia. Am J Psychiatry. 2011 Sep; 168(9):930-46. PMID: 21498463.
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    25. Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):308-13. PMID: 21173249.
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    26. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17; 285(51):39976-85. PMID: 20923771.
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    27. Bhasker CR, Hardiman G. Advances in pharmacogenomics technologies. Pharmacogenomics. 2010 Apr; 11(4):481-5. PMID: 20350126.
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    28. Hardiman G. Development of a bioassay to monitor circulating plasma Ki-67. Leuk Res. 2010 Jul; 34(7):848-9. PMID: 20172610.
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    29. Ponts N, Harris EY, Prudhomme J, Wick I, Eckhardt-Ludka C, Hicks GR, Hardiman G, Lonardi S, Le Roch KG. Nucleosome landscape and control of transcription in the human malaria parasite. Genome Res. 2010 Feb; 20(2):228-38. PMID: 20054063.
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    30. Braudis NJ, Curley MA, Beaupre K, Thomas KC, Hardiman G, Laussen P, Gauvreau K, Thiagarajan RR. Enteral feeding algorithm for infants with hypoplastic left heart syndrome poststage I palliation. Pediatr Crit Care Med. 2009 Jul; 10(4):460-6. PMID: 19307819.
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    31. Ghisletti S, Huang W, Jepsen K, Benner C, Hardiman G, Rosenfeld MG, Glass CK. Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev. 2009 Mar 15; 23(6):681-93. PMID: 19299558.
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    32. Leprohon P, Légaré D, Raymond F, Madore E, Hardiman G, Corbeil J, Ouellette M. Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum. Nucleic Acids Res. 2009 Apr; 37(5):1387-99. PMID: 19129236.
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    33. Boehme SA, Franz-Bacon K, Chen EP, Sásik R, Sprague LJ, Ly TW, Hardiman G, Bacon KB. A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. Int Immunol. 2009 Jan; 21(1):81-93. PMID: 19066314.
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    34. Boehme SA, Chen EP, Franz-Bacon K, Sásik R, Sprague LJ, Ly TW, Hardiman G, Bacon KB. Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms. Int Immunol. 2009 Jan; 21(1):1-17. PMID: 19066315.
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    35. Conrad DJ, Stenbit AE, Zettner EM, Wick I, Eckhardt C, Hardiman G. Frequency of mitochondrial 12S ribosomal RNA variants in an adult cystic fibrosis population. Pharmacogenet Genomics. 2008 Dec; 18(12):1095-102. PMID: 18830133.
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    36. Pellicciotta I, Cortez-Gonzalez X, Sasik R, Reiter Y, Hardiman G, Langlade-Demoyen P, Zanetti M. Presentation of telomerase reverse transcriptase, a self-tumor antigen, is down-regulated by histone deacetylase inhibition. Cancer Res. 2008 Oct 01; 68(19):8085-93. PMID: 18829567.
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    37. Lukacs NW, Berlin AA, Franz-Bacon K, Sásik R, Sprague LJ, Ly TW, Hardiman G, Boehme SA, Bacon KB. CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation. . 2008 Nov; 295(5):L767-79. PMID: 18757520.
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    38. Baker ME, Ruggeri B, Sprague LJ, Eckhardt-Ludka C, Lapira J, Wick I, Soverchia L, Ubaldi M, Polzonetti-Magni AM, Vidal-Dorsch D, Bay S, Gully JR, Reyes JA, Kelley KM, Schlenk D, Breen EC, Sásik R, Hardiman G. Analysis of endocrine disruption in Southern California coastal fish using an aquatic multispecies microarray. Environ Health Perspect. 2009 Feb; 117(2):223-30. PMID: 19270792.
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    39. Sakurai T, He G, Matsuzawa A, Yu GY, Maeda S, Hardiman G, Karin M. Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell. 2008 Aug 12; 14(2):156-65. PMID: 18691550.
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    40. Rouse RJ, Field K, Lapira J, Lee A, Wick I, Eckhardt C, Bhasker CR, Soverchia L, Hardiman G. Development and application of a microarray meter tool to optimize microarray experiments. BMC Res Notes. 2008 Jul 11; 1:45. PMID: 18710498.
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    41. Wheeler MC, Rizzi M, Sasik R, Almanza G, Hardiman G, Zanetti M. KDEL-retained antigen in B lymphocytes induces a proinflammatory response: a possible role for endoplasmic reticulum stress in adaptive T cell immunity. J Immunol. 2008 Jul 01; 181(1):256-64. PMID: 18566391.
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    42. Miller R, Cirulli V, Diaferia GR, Ninniri S, Hardiman G, Torbett BE, Benezra R, Crisa L. Switching-on survival and repair response programs in islet transplants by bone marrow-derived vasculogenic cells. Diabetes. 2008 Sep; 57(9):2402-12. PMID: 18519801.
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    43. Ruggeri B, Ubaldi M, Lourdusamy A, Soverchia L, Ciccocioppo R, Hardiman G, Baker ME, Palermo F, Polzonetti-Magni AM. Variation of the genetic expression pattern after exposure to estradiol-17beta and 4-nonylphenol in male zebrafish (Danio rerio). Gen Comp Endocrinol. 2008 Aug; 158(1):138-44. PMID: 18602103.
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    44. Nguyen N, Bonzo JA, Chen S, Chouinard S, Kelner MJ, Hardiman G, Bélanger A, Tukey RH. Disruption of the ugt1 locus in mice resembles human Crigler-Najjar type I disease. J Biol Chem. 2008 Mar 21; 283(12):7901-11. PMID: 18180294.
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    45. Hardiman G. Applications of microarrays and biochips in pharmacogenomics. Methods Mol Biol. 2008; 448:21-30. PMID: 18370228.
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    46. Hardiman G. Ultra-high-throughput sequencing, microarray-based genomic selection and pharmacogenomics. Pharmacogenomics. 2008 Jan; 9(1):5-9. PMID: 18154443.
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    47. Hardiman G. Microarray technology--advances, applications, future prospects. Pharmacogenomics. 2007 Dec; 8(12):1639-42. PMID: 18085996.
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    48. Economidou D, Mattioli L, Ubaldi M, Lourdusamy A, Soverchia L, Hardiman G, Campolongo P, Cuomo V, Ciccocioppo R. Role of cannabinoidergic mechanisms in ethanol self-administration and ethanol seeking in rat adult offspring following perinatal exposure to Delta9-tetrahydrocannabinol. Toxicol Appl Pharmacol. 2007 Aug 15; 223(1):73-85. PMID: 17618662.
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    49. Hardiman G. Microarrays Technologies 2006: an overview. Pharmacogenomics. 2006 Dec; 7(8):1153-8. PMID: 17184202.
      View in: PubMed
    50. Wick I, Hardiman G. Biochip platforms as functional genomics tools for drug discovery. Curr Opin Drug Discov Devel. 2005 May; 8(3):347-54. PMID: 15892250.
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    51. Soverchia L, Ubaldi M, Leonardi-Essmann F, Ciccocioppo R, Hardiman G. Microarrays--the challenge of preparing brain tissue samples. Addict Biol. 2005 Mar; 10(1):5-13. PMID: 15849014.
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    52. Hardiman G. Microarray platforms--comparisons and contrasts. Pharmacogenomics. 2004 Jul; 5(5):487-502. PMID: 15212585.
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    53. Rouse RJ, Espinoza CR, Niedner RH, Hardiman G. Development of a microarray assay that measures hybridization stoichiometry in moles. Biotechniques. 2004 Mar; 36(3):464-70. PMID: 15038161.
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    54. Rouse R, Hardiman G. Microarray technology--an intellectual property retrospective. Pharmacogenomics. 2003 Sep; 4(5):623-32. PMID: 12943468.
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    55. Hardiman G. Microarray technologies 2003 -- an overview. Pharmacogenomics. 2003 May; 4(3):251-6. PMID: 12718716.
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    56. Talapatra A, Rouse R, Hardiman G. Protein microarrays: challenges and promises. Pharmacogenomics. 2002 Jul; 3(4):527-36. PMID: 12164775.
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    57. Hardiman G. Microarray technologies -- an overview. The University of California San Diego Extension, Bioscience, Microarray Technologies -- an overview, March 13-15, 2002. Pharmacogenomics. 2002 May; 3(3):293-7. PMID: 12052138.
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    58. Link EM, Hardiman G, Sluder AE, Johnson CD, Liu LX. Therapeutic target discovery using Caenorhabditis elegans. Pharmacogenomics. 2000 May; 1(2):203-17. PMID: 11256592.
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    59. Liu LX, Spoerke JM, Mulligan EL, Chen J, Reardon B, Westlund B, Sun L, Abel K, Armstrong B, Hardiman G, King J, McCague L, Basson M, Clover R, Johnson CD. High-throughput isolation of Caenorhabditis elegans deletion mutants. Genome Res. 1999 Sep; 9(9):859-67. PMID: 10508845.
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    60. Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF. A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci U S A. 1998 Jan 20; 95(2):588-93. PMID: 9435236.
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    61. Rossi DL, Hardiman G, Copeland NG, Gilbert DJ, Jenkins N, Zlotnik A, Bazan JF. Cloning and characterization of a new type of mouse chemokine. Genomics. 1998 Jan 15; 47(2):163-70. PMID: 9479488.
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    62. Bazan JF, Bacon KB, Hardiman G, Wang W, Soo K, Rossi D, Greaves DR, Zlotnik A, Schall TJ. A new class of membrane-bound chemokine with a CX3C motif. Nature. 1997 Feb 13; 385(6617):640-4. PMID: 9024663.
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    63. Hardiman G, Kastelein RA, Bazan JF. Isolation, characterization and chromosomal localization of human WNT10B. Cytogenet Cell Genet. 1997; 77(3-4):278-82. PMID: 9284937.
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    64. Hardiman G, Rock FL, Balasubramanian S, Kastelein RA, Bazan JF. Molecular characterization and modular analysis of human MyD88. Oncogene. 1996 Dec 05; 13(11):2467-75. PMID: 8957090.
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    65. Hardiman G, Albright S, Tsunoda J, McClanahan T, Lee F. The mouse Wnt-10B gene isolated from helper T cells is widely expressed and a possible oncogene in BR6 mouse mammary tumorigenesis. Gene. 1996 Jun 26; 172(2):199-205. PMID: 8682303.
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    66. Hardiman G, Byrnes L, Peden J, Wolff J, Gannon F. Cloning and sequencing of the Atlantic salmon (Salmo salar) cytochrome c oxidase subunit III gene (coxIII) and analysis of coxIII expression during parr-smolt transformation. Mol Mar Biol Biotechnol. 1994 Aug; 3(4):210-6. PMID: 8000479.
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