Histone Deacetylases

"Histone Deacetylases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.

Descriptor ID	D006655
MeSH Number(s)	D08.811.277.087.520
Concept/Terms	Histone Deacetylases Histone Deacetylases Deacetylases, Histone Histone Deacetylase Deacetylase, Histone HDAC Proteins Histone Deacetylase Complexes Histone Deacetylase Complexes Complexes, Histone Deacetylase Deacetylase Complexes, Histone Class I Histone Deacetylases Class I Histone Deacetylases Class II Histone Deacetylases Class II Histone Deacetylases

Below are MeSH descriptors whose meaning is more general than "Histone Deacetylases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Amidohydrolases [D08.811.277.087]
Histone Deacetylases [D08.811.277.087.520]

Below are MeSH descriptors whose meaning is related to "Histone Deacetylases".

Below are MeSH descriptors whose meaning is more specific than "Histone Deacetylases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Histone Deacetylases" by people in this website by year, and whether "Histone Deacetylases" was a major or minor topic of these publications.

Bar chart showing 55 publications over 18 distinct years, with a maximum of 7 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	2	2
2004	0	3	3
2005	2	3	5
2006	0	1	1
2007	1	0	1
2008	1	2	3
2009	2	5	7
2010	1	1	2
2011	2	2	4
2012	1	0	1
2013	2	2	4
2014	1	1	2
2015	1	2	3
2016	4	2	6
2017	4	2	6
2018	2	0	2
2019	0	1	1
2020	2	0	2

Below are the most recent publications written about "Histone Deacetylases" by people in Profiles.

Zaidi SAH, Guzman W, Singh S, Mehrotra S, Husain S. Changes in Class I and IIb HDACs by d-Opioid in Chronic Rat Glaucoma Model. Invest Ophthalmol Vis Sci. 2020 12 01; 61(14):4.

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Zaidi SAH, Thakore N, Singh S, Guzman W, Mehrotra S, Gangaraju V, Husain S. Histone Deacetylases Regulation by d-Opioids in Human Optic Nerve Head Astrocytes. Invest Ophthalmol Vis Sci. 2020 09 01; 61(11):17.

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Pierce JL, Roberts RL, Yu K, Kendall RK, Kaiser H, Davis C, Johnson MH, Hill WD, Isales CM, Bollag WB, Hamrick MW, McGee-Lawrence ME. Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo. Exp Gerontol. 2020 02; 130:110818.

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Das A, Henderson F, Lowe S, Wallace GC, Vandergrift WA, Lindhorst SM, Varma AK, Infinger LK, Giglio P, Banik NL, Patel SJ, Cachia D. Single agent efficacy of the HDAC inhibitor DATS in preclinical models of glioblastoma. Cancer Chemother Pharmacol. 2018 12; 82(6):945-952.

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Wright LH, Herr DJ, Brown SS, Kasiganesan H, Menick DR. Angiokine Wisp-1 is increased in myocardial infarction and regulates cardiac endothelial signaling. JCI Insight. 2018 02 22; 3(4).

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Li X, Carreria MB, Witonsky KR, Zeric T, Lofaro OM, Bossert JM, Zhang J, Surjono F, Richie CT, Harvey BK, Son H, Cowan CW, Nestler EJ, Shaham Y. Role of Dorsal Striatum Histone Deacetylase 5 in Incubation of Methamphetamine Craving. Biol Psychiatry. 2018 08 01; 84(3):213-222.

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Akinyemi R, Tiwari HK, Arnett DK, Ovbiagele B, Irvin MR, Wahab K, Sarfo F, Srinivasasainagendra V, Adeoye A, Perry RT, Akpalu A, Jenkins C, Arulogun O, Gebregziabher M, Owolabi L, Obiako R, Sanya E, Komolafe M, Fawale M, Adebayo P, Osaigbovo G, Sunmonu T, Olowoyo P, Chukwuonye I, Obiabo Y, Onoja A, Akinyemi J, Ogbole G, Melikam S, Saulson R, Owolabi M. APOL1, CDKN2A/CDKN2B, and HDAC9 polymorphisms and small vessel ischemic stroke. Acta Neurol Scand. 2018 Jan; 137(1):133-141.

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Taniguchi M, Carreira MB, Cooper YA, Bobadilla AC, Heinsbroek JA, Koike N, Larson EB, Balmuth EA, Hughes BW, Penrod RD, Kumar J, Smith LN, Guzman D, Takahashi JS, Kim TK, Kalivas PW, Self DW, Lin Y, Cowan CW. HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors. Neuron. 2017 Sep 27; 96(1):130-144.e6.

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Isaac RS, Sanulli S, Tibble R, Hornsby M, Ravalin M, Craik CS, Gross JD, Narlikar GJ. Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2. J Mol Biol. 2017 11 24; 429(23):3666-3677.

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Penrod RD, Carreira MB, Taniguchi M, Kumar J, Maddox SA, Cowan CW. Novel role and regulation of HDAC4 in cocaine-related behaviors. Addict Biol. 2018 03; 23(2):653-664.

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