 Glutathione
"Glutathione" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
| Descriptor ID |
D005978
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| MeSH Number(s) |
D12.644.456.448
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| Concept/Terms |
Glutathione- Glutathione
- gamma-L-Glutamyl-L-Cysteinylglycine
- gamma L Glutamyl L Cysteinylglycine
- gamma-L-Glu-L-Cys-Gly
- gamma L Glu L Cys Gly
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Below are MeSH descriptors whose meaning is more general than "Glutathione".
Below are MeSH descriptors whose meaning is more specific than "Glutathione".
This graph shows the total number of publications written about "Glutathione" by people in this website by year, and whether "Glutathione" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 3 | 3 | 6 | | 1992 | 4 | 2 | 6 | | 1993 | 1 | 2 | 3 | | 1994 | 1 | 4 | 5 | | 1995 | 2 | 5 | 7 | | 1996 | 8 | 3 | 11 | | 1997 | 3 | 1 | 4 | | 1998 | 4 | 3 | 7 | | 1999 | 2 | 3 | 5 | | 2000 | 2 | 1 | 3 | | 2001 | 2 | 3 | 5 | | 2002 | 2 | 2 | 4 | | 2003 | 3 | 4 | 7 | | 2004 | 1 | 6 | 7 | | 2005 | 3 | 6 | 9 | | 2006 | 5 | 6 | 11 | | 2007 | 2 | 7 | 9 | | 2008 | 4 | 2 | 6 | | 2009 | 3 | 4 | 7 | | 2010 | 1 | 8 | 9 | | 2011 | 5 | 3 | 8 | | 2012 | 1 | 3 | 4 | | 2013 | 3 | 3 | 6 | | 2014 | 2 | 6 | 8 | | 2015 | 2 | 1 | 3 | | 2016 | 2 | 6 | 8 | | 2017 | 0 | 1 | 1 | | 2018 | 4 | 1 | 5 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Glutathione" by people in Profiles.
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Reginald-Opara JN, Svirskis D, O'Carroll SJ, Sreebhavan S, Dean JM, Wu Z. Optimisation of glutathione conjugation to liposomes quantified with a validated HPLC assay. Int J Pharm. 2019 Aug 15; 567:118451.
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Song JH, Singh N, Luevano LA, Padi SKR, Okumura K, Olive V, Black SM, Warfel NA, Goodrich DW, Kraft AS. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase. Mol Cancer Ther. 2018 12; 17(12):2710-2721.
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Zhang J, Ye ZW, Singh S, Townsend DM, Tew KD. An evolving understanding of the S-glutathionylation cycle in pathways of redox regulation. Free Radic Biol Med. 2018 05 20; 120:204-216.
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Moss HG, Brown TR, Wiest DB, Jenkins DD. N-Acetylcysteine rapidly replenishes central nervous system glutathione measured via magnetic resonance spectroscopy in human neonates with hypoxic-ischemic encephalopathy. J Cereb Blood Flow Metab. 2018 06; 38(6):950-958.
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Zhang J, Ye ZW, Chen W, Manevich Y, Mehrotra S, Ball L, Janssen-Heininger Y, Tew KD, Townsend DM. S-Glutathionylation of estrogen receptor a affects dendritic cell function. J Biol Chem. 2018 03 23; 293(12):4366-4380.
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Killoy KM, Harlan BA, Pehar M, Helke KL, Johnson JA, Vargas MR. Decreased glutathione levels cause overt motor neuron degeneration in hSOD1WT over-expressing mice. Exp Neurol. 2018 04; 302:129-135.
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Echeverri-Ruiz N, Haynes T, Landers J, Woods J, Gemma MJ, Hughes M, Del Rio-Tsonis K. A biochemical basis for induction of retina regeneration by antioxidants. Dev Biol. 2018 01 15; 433(2):394-403.
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Samuvel DJ, Shunmugavel A, Singh AK, Singh I, Khan M. S-Nitrosoglutathione ameliorates acute renal dysfunction in a rat model of lipopolysaccharide-induced sepsis. J Pharm Pharmacol. 2016 Oct; 68(10):1310-9.
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van Gisbergen MW, Cebula M, Zhang J, Ottosson-Wadlund A, Dubois L, Lambin P, Tew KD, Townsend DM, Haenen GR, Drittij-Reijnders MJ, Saneyoshi H, Araki M, Shishido Y, Ito Y, Arnér ES, Abe H, Morgenstern R, Johansson K. Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells. Mol Pharm. 2016 06 06; 13(6):2010-25.
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Diaz-Amarilla P, Miquel E, Trostchansky A, Trias E, Ferreira AM, Freeman BA, Cassina P, Barbeito L, Vargas MR, Rubbo H. Electrophilic nitro-fatty acids prevent astrocyte-mediated toxicity to motor neurons in a cell model of familial amyotrophic lateral sclerosis via nuclear factor erythroid 2-related factor activation. Free Radic Biol Med. 2016 06; 95:112-20.
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