Genomic Instability

"Genomic Instability" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An increased tendency of the GENOME to acquire MUTATIONS when various processes involved in maintaining and replicating the genome are dysfunctional.

Descriptor ID	D042822
MeSH Number(s)	C23.550.362 G05.365.590.335 G05.370
Concept/Terms	Genomic Instability Genomic Instability Genomic Instabilities Instabilities, Genomic Instability, Genomic Genome Instability Genome Instabilities Instabilities, Genome Instability, Genome Genomic Stability Genomic Stability Genomic Stabilities Stabilities, Genomic Stability, Genomic Genome Stability Genome Stabilities Stabilities, Genome Stability, Genome

Below are MeSH descriptors whose meaning is more general than "Genomic Instability".

Diseases [C]
Pathological Conditions, Signs and Symptoms [C23]
Pathologic Processes [C23.550]
Genomic Instability [C23.550.362]
Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Variation [G05.365]
Mutation [G05.365.590]
Genomic Instability [G05.365.590.335]
Genomic Instability [G05.370]

Below are MeSH descriptors whose meaning is related to "Genomic Instability".

Below are MeSH descriptors whose meaning is more specific than "Genomic Instability".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genomic Instability" by people in this website by year, and whether "Genomic Instability" was a major or minor topic of these publications.

Bar chart showing 26 publications over 12 distinct years, with a maximum of 4 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	1	1	2
2006	1	2	3
2009	1	0	1
2010	2	1	3
2011	2	0	2
2012	1	0	1
2013	0	1	1
2015	1	2	3
2016	2	2	4
2017	1	1	2
2018	1	2	3
2019	1	0	1

Below are the most recent publications written about "Genomic Instability" by people in Profiles.

Bradley CC, Gordon AJE, Halliday JA, Herman C. Transcription fidelity: New paradigms in epigenetic inheritance, genome instability and disease. DNA Repair (Amst). 2019 09; 81:102652.

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Sizemore GM, Balakrishnan S, Thies KA, Hammer AM, Sizemore ST, Trimboli AJ, Cuitiño MC, Steck SA, Tozbikian G, Kladney RD, Shinde N, Das M, Park D, Majumder S, Krishnan S, Yu L, Fernandez SA, Chakravarti A, Shields PG, White JR, Yee LD, Rosol TJ, Ludwig T, Park M, Leone G, Ostrowski MC. Stromal PTEN determines mammary epithelial response to radiotherapy. Nat Commun. 2018 07 17; 9(1):2783.

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Parikh RY, Lin H, Gangaraju VK. A critical role for nucleoporin 358 (Nup358) in transposon silencing and piRNA biogenesis in Drosophila. J Biol Chem. 2018 06 15; 293(24):9140-9147.

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Javid M, Sasanakietkul T, Nicolson NG, Gibson CE, Callender GG, Korah R, Carling T. DNA Mismatch Repair Deficiency Promotes Genomic Instability in a Subset of Papillary Thyroid Cancers. World J Surg. 2018 02; 42(2):358-366.

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Chan SSL. Inherited mitochondrial genomic instability and chemical exposures. Toxicology. 2017 11 01; 391:75-83.

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Karam JA, Parikh RY, Nayak D, Rosenkranz D, Gangaraju VK. Co-chaperone Hsp70/Hsp90-organizing protein (Hop) is required for transposon silencing and Piwi-interacting RNA (piRNA) biogenesis. J Biol Chem. 2017 04 14; 292(15):6039-6046.

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Moran RA, Hall RM. Analysis of pCERC7, a small antibiotic resistance plasmid from a commensal ST131 Escherichia coli, defines a diverse group of plasmids that include various segments adjacent to a multimer resolution site and encode the same NikA relaxase accessory protein enabling mobilisation. Plasmid. 2017 01; 89:42-48.

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Eckert MA, Pan S, Hernandez KM, Loth RM, Andrade J, Volchenboum SL, Faber P, Montag A, Lastra R, Peter ME, Yamada SD, Lengyel E. Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube. Cancer Discov. 2016 12; 6(12):1342-1351.

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Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen EJ, Kokkalis A, Roumelioti FM, Gagos S, Tzetis M, Canovas B, Igea A, Ahuja AK, Zellweger R, Havaki S, Kanavakis E, Kletsas D, Roninson IB, Garbis SD, Lopes M, Nebreda A, Thanos D, Blow JJ, Townsend P, Sørensen CS, Bartek J, Gorgoulis VG. Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing. Nat Cell Biol. 2016 07; 18(7):777-89.

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Spear TT, Riley TP, Lyons GE, Callender GG, Roszkowski JJ, Wang Y, Simms PE, Scurti GM, Foley KC, Murray DC, Hellman LM, McMahan RH, Iwashima M, Garrett-Mayer E, Rosen HR, Baker BM, Nishimura MI. Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability. J Leukoc Biol. 2016 09; 100(3):545-57.

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