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Vamsi Krishna Gangaraju

Title
InstitutionMedical University of South Carolina
DepartmentBiochemistry and Molecular Biology
AddressP.O. Box MSC 509
518D
Basic Science Building - 173 Ashley Ave.
Phone843-792-2387
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    Collapse Biography 
    Collapse awards and honors
    2012K99/R00 Pathway to Independence Award, National Institutes of Health
    2004Dissertation Research Award, Southern Illinois University, Carbondale, IL

    Collapse Overview 
    Collapse overview
    Using Drosophila as the model system, one of the major goals of my lab is to delineate the molecular mechanisms by which the Piwi-piRNA pathway silences transposons and maintains genome integrity. Our recent work has shown that epigenetic regulation by Piwi prevents trans-generational phenotypic variations. This work has revealed an unprecedented link between Hsp90, a highly selective molecular chaperone and an anti-cancer target, and Piwi. My lab will extend these studies and further unravel the mechanisms by which heat shock machinery regulates Piwi-piRNA pathway. Lastly, we are also interested in understanding if and how the relationship between piRNA pathway and heat shock machinery plays a role in generation of trans-generational epialleles in response to extreme environmental stress. We hope that this study will provide novel insights into stress response pathways and provide us tools to counteract adverse effects of extreme environmental stress and prevent human disease.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dwyer CJ, Cloud CA, Wang C, Heidt P, Chakraborty P, Duke TF, McGue S, Jeffcoat B, Dunne J, Johnson L, Choi S, Nahhas GJ, Gandy AS, Babic N, Nolte FS, Howe P, Ogretmen B, Gangaraju VK, Tomlinson S, Madden B, Bridges T, Flume PA, Wrangle J, Rubinstein MP, Baliga PK, Nadig SN, Mehrotra S. Comparative analysis of antibodies to SARS-CoV-2 between asymptomatic and convalescent patients. iScience. 2021 Jun 25; 24(6):102489. PMID: 33969281.
      View in: PubMed
    2. Zaidi SAH, Thakore N, Singh S, Guzman W, Mehrotra S, Gangaraju V, Husain S. Histone Deacetylases Regulation by d-Opioids in Human Optic Nerve Head Astrocytes. Invest Ophthalmol Vis Sci. 2020 09 01; 61(11):17. PMID: 32915982.
      View in: PubMed
    3. Chakraborty P, Chatterjee S, Kesarwani P, Thyagarajan K, Iamsawat S, Dalheim A, Nguyen H, Selvam SP, Nasarre P, Scurti G, Hardiman G, Maulik N, Ball L, Gangaraju V, Rubinstein MP, Klauber-DeMore N, Hill EG, Ogretmen B, Yu XZ, Nishimura MI, Mehrotra S. Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells. J Biol Chem. 2019 06 07; 294(23):9198-9212. PMID: 30971427.
      View in: PubMed
    4. Nganga R, Oleinik N, Kim J, Selvam SP, De Palma R, Johnson KA, Parikh RY, Gangaraju V, Peterson Y, Dany M, Stahelin RV, Voelkel-Johnson C, Szulc ZM, Bieberich E, Ogretmen B. Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA-dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis. J Biol Chem. 2019 01 11; 294(2):502-519. PMID: 30420430.
      View in: PubMed
    5. Parikh RY, Lin H, Gangaraju VK. A critical role for nucleoporin 358 (Nup358) in transposon silencing and piRNA biogenesis in Drosophila. J Biol Chem. 2018 06 15; 293(24):9140-9147. PMID: 29735528.
      View in: PubMed
    6. Janakiraman H, House RP, Gangaraju VK, Diehl JA, Howe PH, Palanisamy V. The Long (lncRNA) and Short (miRNA) of It: TGFß-Mediated Control of RNA-Binding Proteins and Noncoding RNAs. Mol Cancer Res. 2018 04; 16(4):567-579. PMID: 29555893.
      View in: PubMed
    7. Grelet S, Link LA, Howley B, Obellianne C, Palanisamy V, Gangaraju VK, Diehl JA, Howe PH. Addendum: A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression. Nat Cell Biol. 2017 11 29; 19(12):1443. PMID: 29184176.
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    8. Grelet S, Link LA, Howley B, Obellianne C, Palanisamy V, Gangaraju VK, Diehl JA, Howe PH. A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression. Nat Cell Biol. 2017 Sep; 19(9):1105-1115. PMID: 28825698.
      View in: PubMed
    9. Karam JA, Parikh RY, Nayak D, Rosenkranz D, Gangaraju VK. Co-chaperone Hsp70/Hsp90-organizing protein (Hop) is required for transposon silencing and Piwi-interacting RNA (piRNA) biogenesis. J Biol Chem. 2017 04 14; 292(15):6039-6046. PMID: 28193840.
      View in: PubMed
    10. Janakiraman H, House RP, Talwar S, Courtney SM, Hazard ES, Hardiman G, Mehrotra S, Howe PH, Gangaraju V, Palanisamy V. Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma. Oncogene. 2017 06 01; 36(22):3137-3148. PMID: 27941877.
      View in: PubMed
    11. Ku HY, Gangaraju VK, Qi H, Liu N, Lin H. Tudor-SN Interacts with Piwi Antagonistically in Regulating Spermatogenesis but Synergistically in Silencing Transposons in Drosophila. PLoS Genet. 2016 Jan; 12(1):e1005813. PMID: 26808625.
      View in: PubMed
    12. Darst RP, Pardo CE, Pondugula S, Gangaraju VK, Nabilsi NH, Bartholomew B, Kladde MP. Simultaneous single-molecule detection of endogenous C-5 DNA methylation and chromatin accessibility using MAPit. Methods Mol Biol. 2012; 833:125-41. PMID: 22183592.
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    13. Gangaraju VK, Yin H, Weiner MM, Wang J, Huang XA, Lin H. Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation. Nat Genet. 2011 Feb; 43(2):153-8. PMID: 21186352.
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    14. Gangaraju VK, Prasad P, Srour A, Kagalwala MN, Bartholomew B. Conformational changes associated with template commitment in ATP-dependent chromatin remodeling by ISW2. Mol Cell. 2009 Jul 10; 35(1):58-69. PMID: 19595716.
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    15. Gangaraju VK, Lin H. MicroRNAs: key regulators of stem cells. Nat Rev Mol Cell Biol. 2009 Feb; 10(2):116-25. PMID: 19165214.
      View in: PubMed
    16. Gangaraju VK, Bartholomew B. Dependency of ISW1a chromatin remodeling on extranucleosomal DNA. Mol Cell Biol. 2007 Apr; 27(8):3217-25. PMID: 17283061.
      View in: PubMed
    17. Gangaraju VK, Bartholomew B. Mechanisms of ATP dependent chromatin remodeling. Mutat Res. 2007 May 01; 618(1-2):3-17. PMID: 17306844.
      View in: PubMed
    18. Vary JC, Gangaraju VK, Qin J, Landel CC, Kooperberg C, Bartholomew B, Tsukiyama T. Yeast Isw1p forms two separable complexes in vivo. Mol Cell Biol. 2003 Jan; 23(1):80-91. PMID: 12482963.
      View in: PubMed
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