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Carole ANNA Oskeritzian

TitleASSOC PROFESSOR-USC
InstitutionUniversity of South Carolina School of Medicine
DepartmentMDC PATH-MICRO
AddressMEDICAL V.A. #2
Columbia, South Carolina 29209
Phone(803)216-3462
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chompunud Na Ayudhya C, Amponnawarat A, Roy S, Oskeritzian CA, Ali H. MRGPRX2 Activation by Rocuronium: Insights from Studies with Human Skin Mast Cells and Missense Variants. Cells. 2021 01 15; 10(1). PMID: 33467419.
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    2. Callahan BN, Kammala AK, Syed M, Yang C, Occhiuto CJ, Nellutla R, Chumanevich AP, Oskeritzian CA, Das R, Subramanian H. Osthole, a Natural Plant Derivative Inhibits MRGPRX2 Induced Mast Cell Responses. Front Immunol. 2020; 11:703. PMID: 32391014.
      View in: PubMed
    3. Mohammed AD, Khan MAW, Chatzistamou I, Chamseddine D, Williams-Kang K, Perry M, Enos R, Murphy A, Gomez G, Aladhami A, Oskeritzian CA, Jolly A, Chang Y, He S, Pan Z, Kubinak JL. Gut Antibody Deficiency in a Mouse Model of CVID Results in Spontaneous Development of a Gluten-Sensitive Enteropathy. Front Immunol. 2019; 10:2484. PMID: 31708923.
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    4. Abebayehu D, Spence AJ, Caslin H, Taruselli M, Haque TT, Kiwanuka KN, Kolawole EM, Chumanevich AP, Sell SA, Oskeritzian CA, Ryan J, Kee SA. Lactic acid suppresses IgE-mediated mast cell function in vitro and in vivo. Cell Immunol. 2019 07; 341:103918. PMID: 31030957.
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    5. Caslin HL, Taruselli MT, Paranjape A, Kiwanuka K, Haque T, Chumanevich AP, Oskeritzian CA, Ryan JJ. The Use of Human and Mouse Mast Cell and Basophil Cultures to Assess Type 2 Inflammation. Methods Mol Biol. 2018; 1799:81-92. PMID: 29956146.
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    6. Chumanevich AP, Wedman PA, Oskeritzian CA. Methods for Analyzing Sphingosine-1-Phosphate Signaling in Human and Mouse Primary Mast Cells. Methods Mol Biol. 2018; 1697:21-30. PMID: 28497335.
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    7. Wedman PA, Aladhami A, Chumanevich AP, Fuseler JW, Oskeritzian CA. Mast cells and sphingosine-1-phosphate underlie prelesional remodeling in a mouse model of eczema. Allergy. 2018 02; 73(2):405-415. PMID: 28905998.
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    8. Ndaw VS, Abebayehu D, Spence AJ, Paez PA, Kolawole EM, Taruselli MT, Caslin HL, Chumanevich AP, Paranjape A, Baker B, Barnstein BO, Haque TT, Kiwanuka KN, Oskeritzian CA, Ryan JJ. TGF-ß1 Suppresses IL-33-Induced Mast Cell Function. J Immunol. 2017 08 01; 199(3):866-873. PMID: 28637902.
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    9. Rodriguez YI, Campos LE, Castro MG, Aladhami A, Oskeritzian CA, Alvarez SE. Sphingosine-1 Phosphate: A New Modulator of Immune Plasticity in the Tumor Microenvironment. Front Oncol. 2016; 6:218. PMID: 27800303.
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    10. Abebayehu D, Spence AJ, Qayum AA, Taruselli MT, McLeod JJ, Caslin HL, Chumanevich AP, Kolawole EM, Paranjape A, Baker B, Ndaw VS, Barnstein BO, Oskeritzian CA, Sell SA, Ryan JJ. Lactic Acid Suppresses IL-33-Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1a-Dependent miR-155 Suppression. J Immunol. 2016 10 01; 197(7):2909-17. PMID: 27559047.
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    11. Paranjape A, Chernushevich O, Qayum AA, Spence AJ, Taruselli MT, Abebayehu D, Barnstein BO, McLeod JJ, Baker B, Bajaj GS, Chumanevich AP, Oskeritzian CA, Ryan JJ. Dexamethasone rapidly suppresses IL-33-stimulated mast cell function by blocking transcription factor activity. J Leukoc Biol. 2016 12; 100(6):1395-1404. PMID: 27443878.
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    12. Qayum AA, Paranjape A, Abebayehu D, Kolawole EM, Haque TT, McLeod JJ, Spence AJ, Caslin HL, Taruselli MT, Chumanevich AP, Baker B, Oskeritzian CA, Ryan JJ. IL-10-Induced miR-155 Targets SOCS1 To Enhance IgE-Mediated Mast Cell Function. J Immunol. 2016 06 01; 196(11):4457-67. PMID: 27183599.
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    13. Kolawole EM, McLeod JJ, Ndaw V, Abebayehu D, Barnstein BO, Faber T, Spence AJ, Taruselli M, Paranjape A, Haque TT, Qayum AA, Kazmi QA, Wijesinghe DS, Sturgill JL, Chalfant CE, Straus DB, Oskeritzian CA, Ryan JJ. Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects. J Immunol. 2016 Feb 15; 196(4):1461-70. PMID: 26773154.
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    14. Chumanevich A, Wedman P, Oskeritzian CA. Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. Mediators Inflamm. 2016; 2016:1503206. PMID: 26884643.
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    15. Wedman P, Aladhami A, Beste M, Edwards MK, Chumanevich A, Fuseler JW, Oskeritzian CA. A New Image Analysis Method Based on Morphometric and Fractal Parameters for Rapid Evaluation of In Situ Mammalian Mast Cell Status. Microsc Microanal. 2015 Dec; 21(6):1573-1581. PMID: 26492872.
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    16. Oskeritzian CA, Hait NC, Wedman P, Chumanevich A, Kolawole EM, Price MM, Falanga YT, Harikumar KB, Ryan JJ, Milstien S, Sabbadini R, Spiegel S. The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses. J Allergy Clin Immunol. 2015 Apr; 135(4):1008-1018.e1. PMID: 25512083.
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    17. Oskeritzian CA. Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer. Mol Immunol. 2015 Jan; 63(1):104-12. PMID: 24766823.
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    18. Fernando J, Faber TW, Pullen NA, Falanga YT, Kolawole EM, Oskeritzian CA, Barnstein BO, Bandara G, Li G, Schwartz LB, Spiegel S, Straus DB, Conrad DH, Bunting KD, Ryan JJ. Genotype-dependent effects of TGF-ß1 on mast cell function: targeting the Stat5 pathway. J Immunol. 2013 Nov 01; 191(9):4505-13. PMID: 24068671.
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    19. Garg K, Pullen NA, Oskeritzian CA, Ryan JJ, Bowlin GL. Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds. Biomaterials. 2013 Jun; 34(18):4439-51. PMID: 23515178.
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    20. Price MM, Oskeritzian CA, Falanga YT, Harikumar KB, Allegood JC, Alvarez SE, Conrad D, Ryan JJ, Milstien S, Spiegel S. A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma. J Allergy Clin Immunol. 2013 Feb; 131(2):501-11.e1. PMID: 22939756.
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    21. Falanga YT, Chaimowitz NS, Charles N, Finkelman FD, Pullen NA, Barbour S, Dholaria K, Faber T, Kolawole M, Huang B, Odom S, Rivera J, Carlyon J, Conrad DH, Spiegel S, Oskeritzian CA, Ryan JJ. Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis. J Immunol. 2012 May 01; 188(9):4360-8. PMID: 22450804.
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    22. Oskeritzian CA. Mast Cells and Wound Healing. Adv Wound Care (New Rochelle). 2012 Feb; 1(1):23-28. PMID: 24527274.
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    23. Ojogun N, Barnstein B, Huang B, Oskeritzian CA, Homeister JW, Miller D, Ryan JJ, Carlyon JA. Anaplasma phagocytophilum infects mast cells via alpha1,3-fucosylated but not sialylated glycans and inhibits IgE-mediated cytokine production and histamine release. Infect Immun. 2011 Jul; 79(7):2717-26. PMID: 21536789.
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    24. Macey MR, Sturgill JL, Morales JK, Falanga YT, Morales J, Norton SK, Yerram N, Shim H, Fernando J, Gifillan AM, Gomez G, Schwartz L, Oskeritzian C, Spiegel S, Conrad D, Ryan JJ. IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis. J Immunol. 2010 May 01; 184(9):4688-95. PMID: 20304823.
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    25. Oskeritzian CA, Price MM, Hait NC, Kapitonov D, Falanga YT, Morales JK, Ryan JJ, Milstien S, Spiegel S. Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema. J Exp Med. 2010 Mar 15; 207(3):465-74. PMID: 20194630.
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    26. Price MM, Kapitonov D, Allegood J, Milstien S, Oskeritzian CA, Spiegel S. Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors. FASEB J. 2009 Oct; 23(10):3506-15. PMID: 19535686.
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    27. Speiran K, Bailey DP, Fernando J, Macey M, Barnstein B, Kolawole M, Curley D, Watowich SS, Murray PJ, Oskeritzian C, Ryan JJ. Endogenous suppression of mast cell development and survival by IL-4 and IL-10. J Leukoc Biol. 2009 May; 85(5):826-36. PMID: 19228815.
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    28. Price MM, Oskeritzian CA, Milstien S, Spiegel S. Sphingosine-1-phosphate synthesis and functions in mast cells. Future Lipidol. 2008 Dec 01; 3(6):665-674. PMID: 19802381.
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    29. Oskeritzian CA, Alvarez SE, Hait NC, Price MM, Milstien S, Spiegel S. Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions. Blood. 2008 Apr 15; 111(8):4193-200. PMID: 18178871.
      View in: PubMed
    30. Oskeritzian CA, Milstien S, Spiegel S. Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis. Pharmacol Ther. 2007 Sep; 115(3):390-9. PMID: 17669501.
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    31. Ryan JJ, Kashyap M, Bailey D, Kennedy S, Speiran K, Brenzovich J, Barnstein B, Oskeritzian C, Gomez G. Mast cell homeostasis: a fundamental aspect of allergic disease. Crit Rev Immunol. 2007; 27(1):15-32. PMID: 17430094.
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    32. Mitra P, Oskeritzian CA, Payne SG, Beaven MA, Milstien S, Spiegel S. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16394-9. PMID: 17050692.
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    33. Payne SG, Oskeritzian CA, Griffiths R, Subramanian P, Barbour SE, Chalfant CE, Milstien S, Spiegel S. The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood. 2007 Feb 01; 109(3):1077-85. PMID: 17008548.
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    34. Hait NC, Oskeritzian CA, Paugh SW, Milstien S, Spiegel S. Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. Biochim Biophys Acta. 2006 Dec; 1758(12):2016-26. PMID: 16996023.
      View in: PubMed
    35. Zhao W, Oskeritzian CA, Pozez AL, Schwartz LB. Cytokine production by skin-derived mast cells: endogenous proteases are responsible for degradation of cytokines. J Immunol. 2005 Aug 15; 175(4):2635-42. PMID: 16081839.
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    36. Oskeritzian CA, Zhao W, Min HK, Xia HZ, Pozez A, Kiev J, Schwartz LB. Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell. J Allergy Clin Immunol. 2005 Jun; 115(6):1162-8. PMID: 15940129.
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    37. Oskeritzian CA, Zhao W, Pozez AL, Cohen NM, Grimes M, Schwartz LB. Neutralizing endogenous IL-6 renders mast cells of the MCT type from lung, but not the MCTC type from skin and lung, susceptible to human recombinant IL-4-induced apoptosis. J Immunol. 2004 Jan 01; 172(1):593-600. PMID: 14688371.
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    38. Lee E, Min HK, Oskeritzian CA, Kambe N, Schwartz LB, Wook Chang H. Recombinant human (rh) stem cell factor and rhIL-4 stimulate differentiation and proliferation of CD3+ cells from umbilical cord blood and CD3+ cells enhance FcepsilonR1 expression on fetal liver-derived mast cells in the presence of rhIL-4. Cell Immunol. 2003 Nov; 226(1):30-6. PMID: 14746805.
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    39. Chong HJ, Andrew Bouton L, Bailey DP, Wright H, Ramirez C, Gharse A, Oskeritzian C, Xia HZ, Zhu J, Paul WE, Kepley C, Schwartz LB, Ryan JJ. IL-4 selectively enhances FcgammaRIII expression and signaling on mouse mast cells. Cell Immunol. 2003 Aug; 224(2):65-73. PMID: 14609572.
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    40. Kambe M, Kambe N, Oskeritzian CA, Schechter N, Schwartz LB. IL-6 attenuates apoptosis, while neither IL-6 nor IL-10 affect the numbers or protease phenotype of fetal liver-derived human mast cells. Clin Exp Allergy. 2001 Jul; 31(7):1077-85. PMID: 11467999.
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    41. Oskeritzian CA, Wang Z, Kochan JP, Grimes M, Du Z, Chang HW, Grant S, Schwartz LB. Recombinant human (rh)IL-4-mediated apoptosis and recombinant human IL-6-mediated protection of recombinant human stem cell factor-dependent human mast cells derived from cord blood mononuclear cell progenitors. J Immunol. 1999 Nov 01; 163(9):5105-15. PMID: 10528217.
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    42. Frandji P, Tkaczyk C, Oskeritzian C, David B, Desaymard C, Mécheri S. Exogenous and endogenous antigens are differentially presented by mast cells to CD4+ T lymphocytes. Eur J Immunol. 1996 Oct; 26(10):2517-28. PMID: 8898968.
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    43. Oskeritzian C, Prouvost-Danon A, David B. Effects of L-leucine methyl ester (Leu-OMe) on mouse peritoneal mast cells: characterization of histamine release versus cytotoxicity. Cell Immunol. 1992 Feb; 139(2):281-91. PMID: 1370763.
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