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Lalima G. Ahuja

Title
InstitutionMedical University of South Carolina
DepartmentCell and Molecular Pharmacology and Experimental Therapeutics
AddressBSB313E
Basic Science Building - 173 Ashley Ave.
Phone843-792-4525
Fax843-792-0481
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lu TW, Wu J, Aoto PC, Weng JH, Ahuja LG, Sun N, Cheng CY, Zhang P, Taylor SS. Two PKA RIa holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP. Proc Natl Acad Sci U S A. 2019 Aug 13; 116(33):16347-16356. PMID: 31363049.
      View in: PubMed
    2. Ahuja LG, Aoto PC, Kornev AP, Veglia G, Taylor SS. Dynamic allostery-based molecular workings of kinase:peptide complexes. Proc Natl Acad Sci U S A. 2019 Jul 23; 116(30):15052-15061. PMID: 31285328.
      View in: PubMed
    3. Ahuja LG, Taylor SS, Kornev AP. Tuning the "violin" of protein kinases: The role of dynamics-based allostery. IUBMB Life. 2019 06; 71(6):685-696. PMID: 31063633.
      View in: PubMed
    4. Wang Y, V S M, Kim J, Li G, Ahuja LG, Aoto P, Taylor SS, Veglia G. Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase's enzymatic cycle. Nat Commun. 2019 02 18; 10(1):799. PMID: 30778078.
      View in: PubMed
    5. Meng Y, Ahuja LG, Kornev AP, Taylor SS, Roux B. Corrigendum to "A Catalytically-Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation." J. Mol. Biol. 430(6) (Mar 16 2018), 881-889. J Mol Biol. 2018 Oct 19; 430(21):4439. PMID: 30220583.
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    6. Meng Y, Ahuja LG, Kornev AP, Taylor SS, Roux B. A Catalytically Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation. J Mol Biol. 2018 03 16; 430(6):881-889. PMID: 29410316.
      View in: PubMed
    7. Kim J, Ahuja LG, Chao FA, Xia Y, McClendon CL, Kornev AP, Taylor SS, Veglia G. A dynamic hydrophobic core orchestrates allostery in protein kinases. Sci Adv. 2017 Apr; 3(4):e1600663. PMID: 28435869.
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    8. Ahuja LG, Kornev AP, McClendon CL, Veglia G, Taylor SS. Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer. Proc Natl Acad Sci U S A. 2017 02 07; 114(6):E931-E940. PMID: 28115705.
      View in: PubMed
    9. Meharena HS, Fan X, Ahuja LG, Keshwani MM, McClendon CL, Chen AM, Adams JA, Taylor SS. Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases. PLoS Biol. 2016 Nov; 14(11):e2000127. PMID: 27902690.
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    10. Knape MJ, Ahuja LG, Bertinetti D, Burghardt NC, Zimmermann B, Taylor SS, Herberg FW. Divalent Metal Ions Mg²? and Ca²? Have Distinct Effects on Protein Kinase A Activity and Regulation. ACS Chem Biol. 2015 Oct 16; 10(10):2303-15. PMID: 26200257.
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    11. Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor SS. Single Turnover Autophosphorylation Cycle of the PKA RIIß Holoenzyme. PLoS Biol. 2015 Jul; 13(7):e1002192. PMID: 26158466.
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    12. Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor SS, Shaw AS. Kinase regulation by hydrophobic spine assembly in cancer. Mol Cell Biol. 2015 Jan; 35(1):264-76. PMID: 25348715.
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    13. Moretti DM, Ahuja LG, Nunes RD, Cudischevitch CO, Daumas-Filho CR, Medeiros-Castro P, Ventura-Martins G, Jablonka W, Gazos-Lopes F, Senna R, Sorgine MH, Hartfelder K, Capurro M, Atella GC, Mesquita RD, Silva-Neto MA. Molecular analysis of Aedes aegypti classical protein tyrosine phosphatases uncovers an ortholog of mammalian PTP-1B implicated in the control of egg production in mosquitoes. PLoS One. 2014; 9(8):e104878. PMID: 25137153.
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    14. Shaw AS, Kornev AP, Hu J, Ahuja LG, Taylor SS. Kinases and pseudokinases: lessons from RAF. Mol Cell Biol. 2014 May; 34(9):1538-46. PMID: 24567368.
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    15. Ahuja LG, Gopal B. Bi-domain protein tyrosine phosphatases reveal an evolutionary adaptation to optimize signal transduction. Antioxid Redox Signal. 2014 May 10; 20(14):2141-59. PMID: 24206235.
      View in: PubMed
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