George E. Tempel

Title
InstitutionMedical University of South Carolina
DepartmentNeuroscience
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fan H, Zingarelli B, Harris V, Tempel GE, Halushka PV, Cook JA. Lysophosphatidic acid inhibits bacterial endotoxin-induced pro-inflammatory response: potential anti-inflammatory signaling pathways. Mol Med. 2008 Jul-Aug; 14(7-8):422-8. PMID: 18431464.
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    2. Basher F, Fan H, Zingarelli B, Borg KT, Luttrell LM, Tempel GE, Halushka PV, Cook JA. beta-Arrestin 2: a Negative Regulator of Inflammatory Responses in Polymorphonuclear Leukocytes. Int J Clin Exp Med. 2008; 1(1):32-41. PMID: 19079685.
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    3. Fan H, Williams DL, Zingarelli B, Breuel KF, Teti G, Tempel GE, Spicher K, Boulay G, Birnbaumer L, Halushka PV, Cook JA. Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins. Immunology. 2007 Sep; 122(1):116-23. PMID: 17484771.
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    4. Fan H, Luttrell LM, Tempel GE, Senn JJ, Halushka PV, Cook JA. Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression. Mol Immunol. 2007 May; 44(12):3092-9. PMID: 17418896.
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    5. Fan H, Williams DL, Breuel KF, Zingarelli B, Teti G, Tempel GE, Halushka PV, Cook JA. Gi proteins regulate lipopolysaccharide and Staphylococcus aureus induced cytokine production but not (1--> 3)-beta-D-glucan induced cytokine suppression. Front Biosci. 2006 Sep 01; 11:2264-74. PMID: 16720313.
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    6. Fan H, Williams DL, Zingarelli B, Breuel KF, Teti G, Tempel GE, Spicher K, Boulay G, Birnbaumer L, Halushka PV, Cook JA. Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins. Biochim Biophys Acta. 2006 Oct; 1763(10):1051-8. PMID: 16962188.
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    7. Peck OM, Zingarelli B, Fan H, Teti G, Tempel G, Halushka PV, Cook JA. The phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharide. Shock. 2006 Jul; 26(1):31-6. PMID: 16783195.
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    8. Fan H, Zingarelli B, Peck OM, Teti G, Tempel GE, Halushka PV, Spicher K, Boulay G, Birnbaumer L, Cook JA. Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins. . 2005 Aug; 289(2):C293-301. PMID: 15788486.
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    9. Fan H, Peck OM, Tempel GE, Halushka PV, Cook JA. Toll-like receptor 4 coupled GI protein signaling pathways regulate extracellular signal-regulated kinase phosphorylation and AP-1 activation independent of NFkappaB activation. Shock. 2004 Jul; 22(1):57-62. PMID: 15201703.
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    10. Peck OM, Williams DL, Breuel KF, Kalbfleisch JH, Fan H, Tempel GE, Teti G, Cook JA. Differential regulation of cytokine and chemokine production in lipopolysaccharide-induced tolerance and priming. Cytokine. 2004 Jun 07; 26(5):202-8. PMID: 15157897.
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    11. Peck OM, Fan H, Tempel GE, Teti G, Halushka PV, Cook JA. Staphylococcus aureus and lipopolysaccharide induce homologous tolerance but heterologous priming: role of interferon-gamma. Shock. 2004 Mar; 21(3):254-60. PMID: 14770039.
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    12. Guyton K, Zingarelli B, Ashton S, Teti G, Tempel G, Reilly C, Gilkeson G, Halushka P, Cook J. Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli. Shock. 2003 Jul; 20(1):56-62. PMID: 12813370.
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    13. Fan H, Teti G, Ashton S, Guyton K, Tempel GE, Halushka PV, Cook JA. Involvement of G(i) proteins and Src tyrosine kinase in TNFalpha production induced by lipopolysaccharide, group B Streptococci and Staphylococcus aureus. Cytokine. 2003 Jun 07; 22(5):126-33. PMID: 12842760.
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    14. Tempel GE, Brown AN, Morinelli TA, Halushka PV, Cook JA. Changes in vascular responsiveness to a thromboxane mimetic in endotoxin tolerance. Shock. 2001 Nov; 16(5):389-92. PMID: 11699079.
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    15. Caparas SN, Clair MJ, Krombach RS, Hendrick JW, Houck WV, Kribbs SB, Mukherjee R, Tempel GE, Spinale FG. Brain blood flow patterns after the development of congestive heart failure: effects of treadmill exercise. Crit Care Med. 2000 Jan; 28(1):209-14. PMID: 10667524.
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    16. Vacchiano CA, Osborne GR, Tempel GE. 8-ISO-PGF2alpha production by alveolar macrophages exposed to hyperoxia. Shock. 1998 Apr; 9(4):266-73. PMID: 9565255.
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    17. O SJ, Zellner JL, Cox MH, Hebbar L, Brothers TE, Mukherjee R, Tempel GE, Dorman BH, Crawford FA, Spinale FG. Contributory mechanisms for the beneficial effects of myocyte preconditioning during cardioplegic arrest. Circulation. 1996 Nov 01; 94(9 Suppl):II389-97. PMID: 8901780.
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    18. Vacchiano CA, Tempel GE. Role of nonenzymatically generated prostanoid, 8-iso-PGF2 alpha, in pulmonary oxygen toxicity. J Appl Physiol (1985). 1994 Dec; 77(6):2912-7. PMID: 7896640.
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    19. Spinale FG, Tempel GE, Mukherjee R, Eble DM, Brown R, Vacchiano CA, Zile MR. Cellular and molecular alterations in the beta adrenergic system with cardiomyopathy induced by tachycardia. Cardiovasc Res. 1994 Aug; 28(8):1243-50. PMID: 7954628.
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    20. Morinelli TA, Tempel GE, Jaffa AA, Silva RH, Naka M, Folger W, Halushka PV. Thromboxane A2/prostaglandin H2 receptors in streptozotocin-induced diabetes: effects of insulin therapy in the rat. Prostaglandins. 1993 May; 45(5):427-38. PMID: 8321912.
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    21. Coffee KA, Halushka PV, Ashton SH, Tempel GE, Wise WC, Cook JA. Endotoxin tolerance is associated with altered GTP-binding protein function. J Appl Physiol (1985). 1992 Sep; 73(3):1008-13. PMID: 1400011.
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    22. Tempel GE, Martin HF. The beneficial effects of a thromboxane receptor antagonist on spinal cord perfusion following experimental cord injury. J Neurol Sci. 1992 Jun; 109(2):162-7. PMID: 1386102.
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    23. Spinale FG, Grine RC, Tempel GE, Crawford FA, Zile MR. Alterations in the myocardial capillary vasculature accompany tachycardia-induced cardiomyopathy. Basic Res Cardiol. 1992 Jan-Feb; 87(1):65-79. PMID: 1567354.
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    24. Spinale FG, Zellner JL, Tomita M, Tempel GE, Crawford FA, Zile MR. Tachycardia-induced cardiomyopathy: effects on blood flow and capillary structure. Am J Physiol. 1991 Jul; 261(1 Pt 2):H140-8. PMID: 1858914.
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    25. Coffee KA, Halushka PV, Wise WC, Tempel GE, Cook JA. Endotoxin tolerance differentially alters hemodynamic responses to a thromboxane A2 mimetic and phenylephrine. J Cardiovasc Pharmacol. 1991 Jan; 17(1):20-6. PMID: 1708052.
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    26. Tempel GE, Strong JW, Wise WC, Cook JA, Smith EF, Halushka PV. The role of eicosanoids in mediating blood flow alterations in endotoxin shock. Prog Clin Biol Res. 1989; 299:33-42. PMID: 2498907.
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    27. Wise WC, Cook JA, Tempel GE, Reines HD, Halushka PV. The rat in sepsis and endotoxic shock. Prog Clin Biol Res. 1989; 299:243-52. PMID: 2657793.
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    28. Matera G, Cook JA, Hennigar RA, Tempel GE, Wise WC, Oglesby TD, Halushka PV. Beneficial effects of a 5-lipoxygenase inhibitor in endotoxic shock in the rat. J Pharmacol Exp Ther. 1988 Oct; 247(1):363-71. PMID: 3171981.
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    29. Etemadi AR, Tempel GE, Farah BA, Wise WC, Halushka PV, Cook JA. Beneficial effects of a leukotriene antagonist on endotoxin-induced acute hemodynamic alterations. Circ Shock. 1987; 22(1):55-63. PMID: 3038364.
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    30. Tempel GE, Cook JA, Wise WC, Halushka PV, Corral D. Improvement in organ blood flow by inhibition of thromboxane synthetase during experimental endotoxic shock in the rat. J Cardiovasc Pharmacol. 1986 May-Jun; 8(3):514-9. PMID: 2425166.
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    31. Armstrong J, Tempel GE, Cook JA, Wise WC, Halushka PV. The effects of alpha adrenergic blockade on arachidonic acid metabolism and shock sequelae in endotoxemia. Circ Shock. 1986; 20(2):151-9. PMID: 3096591.
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    32. Smith EF, Tempel GE, Wise WC, Halushka PV, Cook JA. Experimental endotoxemia in the rat: efficacy of prostacyclin or the prostacyclin analog iloprost. Circ Shock. 1985; 16(1):1-7. PMID: 2414027.
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    33. Cook JA, Wise WC, Tempel GE, Halushka PV. Exchange transfusions in rats with a perfluorated blood substitute: effect on thromboxane B2 levels during endotoxemia. Circ Shock. 1985; 15(3):193-204. PMID: 3978769.
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    34. Tempel GE, Cook JA, Wise WC, Halushka PV. The improvement in endotoxin-induced redistribution of organ blood flow by inhibition of thromboxane and prostaglandin synthesis. Adv Shock Res. 1982; 7:209-18. PMID: 6753535.
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    35. Tempel GE, Musacchia XJ, Jones SB. Mechanisms responsible for decreased glomerular filtration in hibernation and hypothermia. J Appl Physiol Respir Environ Exerc Physiol. 1977 Mar; 42(3):420-5. PMID: 838661.
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    36. Jones SB, Musacchia XJ, Tempel GE. Mechanisms of temperature regulation in heat-acclimated hamsters. Am J Physiol. 1976 Sep; 231(3):707-12. PMID: 970452.
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    37. Johnson JA, Davis JO, Gotshall RW, Lohmeier TE, Davis JL, Braverman B, Tempel GE. Evidence for an intrarenal beta receptor in control of renin release. Am J Physiol. 1976 Feb; 230(2):410-8. PMID: 1259022.
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    38. Tempel GE, Musacchia XJ. Renal function in the hibernating, and hypothermic hamster Mesocricetus auratus. Am J Physiol. 1975 Feb; 228(2):602-7. PMID: 1119581.
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