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Michael Wyatt

Title
InstitutionMedical University of South Carolina
DepartmentSCCP Pharmaceutical and Biomedical Sciences - USC Campus
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bennett CL, Schoen MW, Hoque S, Witherspoon BJ, Aboulafia DM, Hwang CS, Ray P, Yarnold PR, Chen BK, Schooley B, Taylor MA, Wyatt MD, Hrushesky WJ, Yang YT. Improving oncology biosimilar launches in the EU, the USA, and Japan: an updated Policy Review from the Southern Network on Adverse Reactions. Lancet Oncol. 2020 12; 21(12):e575-e588. PMID: 33271114.
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    2. Cui BC, Sikirzhytski V, Aksenova M, Lucius MD, Levon GH, Mack ZT, Pollack C, Odhiambo D, Broude E, Lizarraga SB, Wyatt MD, Shtutman M. Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly. Biochem Pharmacol. 2020 12; 182:114280. PMID: 33049245.
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    3. Chaparala A, Poudyal D, Tashkandi H, Witalison EE, Chumanevich AA, Hofseth JL, Nguyen I, Hardy O, Pittman DL, Wyatt MD, Windust A, Murphy EA, Nagarkatti M, Nagarkatti P, Hofseth LJ. Panaxynol, a bioactive component of American ginseng, targets macrophages and suppresses colitis in mice. Oncotarget. 2020 Jun 02; 11(22):2026-2036. PMID: 32547701.
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    4. Baxter M, Chapagai D, Craig S, Hurtado C, Varghese J, Nurmemmedov E, Wyatt MD, McInnes C. Peptidomimetic Polo-Box-Targeted Inhibitors that Engage PLK1 in Tumor Cells and Are Selective against the PLK3 Tumor Suppressor. ChemMedChem. 2020 06 17; 15(12):1058-1066. PMID: 32232973.
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    5. LeBegue CE, Love BL, Wyatt MD. Microbes as Drugs: The Potential of Pharmabiotics. Pharmacotherapy. 2020 02; 40(2):102-106. PMID: 31863487.
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    6. Aksenova M, Sybrandt J, Cui B, Sikirzhytski V, Ji H, Odhiambo D, Lucius MD, Turner JR, Broude E, Peña E, Lizarraga S, Zhu J, Safro I, Wyatt MD, Shtutman M. Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation. J Neuroimmune Pharmacol. 2020 06; 15(2):209-223. PMID: 31802418.
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    7. Adeluyi A, Guerin L, Fisher ML, Galloway A, Cole RD, Chan SSL, Wyatt MD, Davis SW, Freeman LR, Ortinski PI, Turner JR. Microglia morphology and proinflammatory signaling in the nucleus accumbens during nicotine withdrawal. Sci Adv. 2019 10; 5(10):eaax7031. PMID: 31633029.
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    8. Wyatt MD, Pittman DL. Potential unintended consequences of getting rigorous with scientific rigor. Carcinogenesis. 2018 01 12; 39(1):26-27. PMID: 29045573.
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    9. Wyatt MD, Reilly NM, Patel S, Rajesh P, Schools GP, Smiraldo PG, Pittman DL. Thiopurine-induced mitotic catastrophe in Rad51d-deficient mammalian cells. Environ Mol Mutagen. 2018 01; 59(1):38-48. PMID: 28945288.
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    10. Anderson EL, Banister CE, Kassler S, Messersmith A, Pirisi L, Creek KE, Wyatt MD. Human Papillomavirus Type 16 L2 DNA Methylation in Exfoliated Cervical Cells From College-Age Women: Erratum. J Low Genit Tract Dis. 2017 04; 21(2):162. PMID: 28548641.
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    11. Oliver D, Ji H, Liu P, Gasparian A, Gardiner E, Lee S, Zenteno A, Perinskaya LO, Chen M, Buckhaults P, Broude E, Wyatt MD, Valafar H, Peña E, Shtutman M. Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen. Sci Rep. 2017 02 22; 7:43023. PMID: 28223711.
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    12. Sutton SS, Jumper M, Cook S, Edun B, Wyatt MD. Ertapenem-Induced Encephalopathy in a Patient With Normal Renal Function. J Investig Med High Impact Case Rep. 2017 Jan-Mar; 5(1):2324709616689376. PMID: 28203577.
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    13. Anderson EL, Banister CE, Kassler S, Messersmith A, Pirisi L, Creek KE, Wyatt MD. Human Papillomavirus Type 16 L2 DNA Methylation in Exfoliated Cervical Cells From College-Age Women. J Low Genit Tract Dis. 2016 10; 20(4):332-7. PMID: 27518844.
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    14. Preet R, Siddharth S, Satapathy SR, Das S, Nayak A, Das D, Wyatt MD, Kundu CN. Chk1 inhibitor synergizes quinacrine mediated apoptosis in breast cancer cells by compromising the base excision repair cascade. Biochem Pharmacol. 2016 Apr 01; 105:23-33. PMID: 26850987.
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    15. Premnath PN, Craig SN, Liu S, Anderson EL, Grigoroudis AI, Kontopidis G, Perkins TL, Wyatt MD, Pittman DL, McInnes C. Iterative conversion of cyclin binding groove peptides into druglike CDK inhibitors with antitumor activity. J Med Chem. 2015 Jan 08; 58(1):433-42. PMID: 25454794.
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    16. Das D, Preet R, Mohapatra P, Satapathy SR, Siddharth S, Tamir T, Jain V, Bharatam PV, Wyatt MD, Kundu CN. 5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway. DNA Repair (Amst). 2014 Dec; 24:15-25. PMID: 25460919.
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    17. Bennett CL, Chen B, Hermanson T, Wyatt MD, Schulz RM, Georgantopoulos P, Kessler S, Raisch DW, Qureshi ZP, Lu ZK, Love BL, Noxon V, Bobolts L, Armitage M, Bian J, Ray P, Ablin RJ, Hrushesky WJ, Macdougall IC, Sartor O, Armitage JO. Regulatory and clinical considerations for biosimilar oncology drugs. Lancet Oncol. 2014 Dec; 15(13):e594-e605. PMID: 25456378.
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    18. Craig SN, Wyatt MD, McInnes C. Current assessment of polo-like kinases as anti-tumor drug targets. Expert Opin Drug Discov. 2014 Jul; 9(7):773-89. PMID: 24819909.
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    19. Wyatt MD. Advances in understanding the coupling of DNA base modifying enzymes to processes involving base excision repair. Adv Cancer Res. 2013; 119:63-106. PMID: 23870509.
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    20. Nagaria P, Svilar D, Brown AR, Wang XH, Sobol RW, Wyatt MD. SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress. Mutat Res. 2013 Mar-Apr; 743-744:26-32. PMID: 23253900.
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    21. Preet R, Mohapatra P, Das D, Satapathy SR, Choudhuri T, Wyatt MD, Kundu CN. Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC. Carcinogenesis. 2013 Feb; 34(2):277-86. PMID: 23129580.
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    22. McInnes C, Estes K, Baxter M, Yang Z, Farag DB, Johnston P, Lazo JS, Wang J, Wyatt MD. Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype. . 2012 Aug; 11(8):1683-92. PMID: 22848093.
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    23. Yang Z, Waldman AS, Wyatt MD. Expression and regulation of RAD51 mediate cellular responses to chemotherapeutics. Biochem Pharmacol. 2012 Mar 15; 83(6):741-6. PMID: 22222428.
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    24. Preet R, Mohapatra P, Mohanty S, Sahu SK, Choudhuri T, Wyatt MD, Kundu CN. Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity. Int J Cancer. 2012 Apr 01; 130(7):1660-70. PMID: 21544805.
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    25. McInnes C, Wyatt MD. PLK1 as an oncology target: current status and future potential. Drug Discov Today. 2011 Jul; 16(13-14):619-25. PMID: 21601650.
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    26. Rajesh P, Litvinchuk AV, Pittman DL, Wyatt MD. The homologous recombination protein RAD51D mediates the processing of 6-thioguanine lesions downstream of mismatch repair. Mol Cancer Res. 2011 Feb; 9(2):206-14. PMID: 21205838.
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    27. Alkilany AM, Nagaria PK, Wyatt MD, Murphy CJ. Cation exchange on the surface of gold nanorods with a polymerizable surfactant: polymerization, stability, and toxicity evaluation. Langmuir. 2010 Jun 15; 26(12):9328-33. PMID: 20356032.
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    28. Rajesh P, Rajesh C, Wyatt MD, Pittman DL. RAD51D protects against MLH1-dependent cytotoxic responses to O(6)-methylguanine. DNA Repair (Amst). 2010 Apr 04; 9(4):458-67. PMID: 20133210.
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    29. Jones LE, Ying L, Hofseth AB, Jelezcova E, Sobol RW, Ambs S, Harris CC, Espey MG, Hofseth LJ, Wyatt MD. Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase. Carcinogenesis. 2009 Dec; 30(12):2123-9. PMID: 19864471.
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    30. Alkilany AM, Nagaria PK, Hexel CR, Shaw TJ, Murphy CJ, Wyatt MD. Cellular uptake and cytotoxicity of gold nanorods: molecular origin of cytotoxicity and surface effects. Small. 2009 Mar; 5(6):701-8. PMID: 19226599.
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    31. Gole A, Agarwal N, Nagaria P, Wyatt MD, Murphy CJ. One-pot synthesis of silica-coated magnetic plasmonic tracer nanoparticles. Chem Commun (Camb). 2008 Dec 14; (46):6140-2. PMID: 19082099.
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    32. Yang Z, Waldman AS, Wyatt MD. DNA damage and homologous recombination signaling induced by thymidylate deprivation. Biochem Pharmacol. 2008 Oct 15; 76(8):987-96. PMID: 18773878.
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    33. Waldman BC, Wang Y, Kilaru K, Yang Z, Bhasin A, Wyatt MD, Waldman AS. Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase. DNA Repair (Amst). 2008 Oct 01; 7(10):1624-35. PMID: 18603020.
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    34. Berger SH, Pittman DL, Wyatt MD. Uracil in DNA: consequences for carcinogenesis and chemotherapy. Biochem Pharmacol. 2008 Sep 15; 76(6):697-706. PMID: 18599024.
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    35. Luo Y, Walla M, Wyatt MD. Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase. DNA Repair (Amst). 2008 Feb 01; 7(2):162-9. PMID: 17942376.
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    36. Wyatt MD, Pittman DL. Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks. Chem Res Toxicol. 2006 Dec; 19(12):1580-94. PMID: 17173371.
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    37. You S, Ohmori M, Peña MM, Nassri B, Quiton J, Al-Assad ZA, Liu L, Wood PA, Berger SH, Liu Z, Wyatt MD, Price RL, Berger FG, Hrushesky WJ. Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice. Int J Exp Pathol. 2006 Jun; 87(3):227-36. PMID: 16709231.
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    38. Sen S, Paraggio NA, Gearheart LA, Connor EE, Issa A, Coleman RS, Wilson DM, Wyatt MD, Berg MA. Effect of protein binding on ultrafast DNA dynamics: characterization of a DNA:APE1 complex. Biophys J. 2005 Dec; 89(6):4129-38. PMID: 16199493.
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    39. Li L, Connor EE, Berger SH, Wyatt MD. Determination of apoptosis, uracil incorporation, DNA strand breaks, and sister chromatid exchanges under conditions of thymidylate deprivation in a model of BER deficiency. Biochem Pharmacol. 2005 Nov 15; 70(10):1458-68. PMID: 16191427.
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    40. Connor EE, Mwamuka J, Gole A, Murphy CJ, Wyatt MD. Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small. 2005 Mar; 1(3):325-7. PMID: 17193451.
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    41. Connor EE, Wilson JJ, Wyatt MD. Effects of substrate specificity on initiating the base excision repair of N-methylpurines by variant human 3-methyladenine DNA glycosylases. Chem Res Toxicol. 2005 Jan; 18(1):87-94. PMID: 15651853.
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    42. Hitchcock TM, Dong L, Connor EE, Meira LB, Samson LD, Wyatt MD, Cao W. Oxanine DNA glycosylase activity from Mammalian alkyladenine glycosylase. J Biol Chem. 2004 Sep 10; 279(37):38177-83. PMID: 15247209.
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    43. Li L, Berger SH, Wyatt MD. Involvement of base excision repair in response to therapy targeted at thymidylate synthase. . 2004 Jun; 3(6):747-53. PMID: 15210861.
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    44. Connor EE, Wyatt MD. Active-site clashes prevent the human 3-methyladenine DNA glycosylase from improperly removing bases. Chem Biol. 2002 Sep; 9(9):1033-41. PMID: 12323378.
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