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John Cavanagh

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InstitutionMedical University of South Carolina
DepartmentBiochemistry and Molecular Biology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dean SN, Milton ME, Cavanagh J, van Hoek ML. Francisella novicida Two-Component System Response Regulator BfpR Modulates iglC Gene Expression, Antimicrobial Peptide Resistance, and Biofilm Production. Front Cell Infect Microbiol. 2020; 10:82. PMID: 32232010.
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    2. Milton ME, Draughn GL, Bobay BG, Stowe SD, Olson AL, Feldmann EA, Thompson RJ, Myers KH, Santoro MT, Kearns DB, Cavanagh J. The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis. J Mol Biol. 2020 01 17; 432(2):343-357. PMID: 31493408.
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    3. Milton ME, Minrovic BM, Harris DL, Kang B, Jung D, Lewis CP, Thompson RJ, Melander RJ, Zeng D, Melander C, Cavanagh J. Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp. Front Mol Biosci. 2018; 5:15. PMID: 29487854.
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    4. Draughn GL, Milton ME, Feldmann EA, Bobay BG, Roth BM, Olson AL, Thompson RJ, Actis LA, Davies C, Cavanagh J. The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism. J Mol Biol. 2018 03 16; 430(6):806-821. PMID: 29438671.
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    5. Milton ME, Allen CL, Feldmann EA, Bobay BG, Jung DK, Stephens MD, Melander RJ, Theisen KE, Zeng D, Thompson RJ, Melander C, Cavanagh J. Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds. Mol Microbiol. 2017 Oct; 106(2):223-235. PMID: 28755524.
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    6. Draughn GL, Allen CL, Routh PA, Stone MR, Kirker KR, Boegli L, Schuchman RM, Linder KE, Baynes RE, James G, Melander C, Pollard A, Cavanagh J. Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections. Drug Des Devel Ther. 2017; 11:153-162. PMID: 28138218.
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    7. Feldmann EA, Cavanagh J. Teaching old drugs new tricks: Addressing resistance in Francisella. Virulence. 2015; 6(5):414-6. PMID: 26055396.
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    8. Stowe SD, Thompson RJ, Peng L, Su Z, Blackledge MS, Draughn GL, Coe WH, Johannes E, Lapham VK, Mackenzie J, Melander C, Cavanagh J. Membrane-permeabilizing activity of reverse-amide 2-aminoimidazole antibiofilm agents against Acinetobacter baumannii. Curr Drug Deliv. 2015; 12(2):223-30. PMID: 25348099.
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    9. Olson AL, Tucker AT, Bobay BG, Soderblom EJ, Moseley MA, Thompson RJ, Cavanagh J. Structure and DNA-binding traits of the transition state regulator AbrB. Structure. 2014 Nov 04; 22(11):1650-6. PMID: 25308864.
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    10. Brackett CM, Melander RJ, An IH, Krishnamurthy A, Thompson RJ, Cavanagh J, Melander C. Small-molecule suppression of ß-lactam resistance in multidrug-resistant gram-negative pathogens. J Med Chem. 2014 Sep 11; 57(17):7450-8. PMID: 25137478.
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    11. Tucker AT, Bobay BG, Banse AV, Olson AL, Soderblom EJ, Moseley MA, Thompson RJ, Varney KM, Losick R, Cavanagh J. A DNA mimic: the structure and mechanism of action for the anti-repressor protein AbbA. J Mol Biol. 2014 May 01; 426(9):1911-24. PMID: 24534728.
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    12. Bobay BG, Thompson RJ, Milton DL, Cavanagh J. Chemical shift assignments and secondary structure prediction of the phosphorelay protein VanU from Vibrio anguillarum. Biomol NMR Assign. 2014 Apr; 8(1):177-9. PMID: 23604692.
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    13. Stowe SD, Olson AL, Losick R, Cavanagh J. Chemical shift assignments and secondary structure prediction of the master biofilm regulator, SinR, from Bacillus subtilis. Biomol NMR Assign. 2014 Apr; 8(1):155-8. PMID: 23475644.
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    14. Olson AL, Liu F, Tucker AT, Goshe MB, Cavanagh J. Chemical crosslinking and LC/MS analysis to determine protein domain orientation: application to AbrB. Biochem Biophys Res Commun. 2013 Feb 08; 431(2):253-7. PMID: 23313475.
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    15. Olson AL, Thompson RJ, Melander C, Cavanagh J. Chemical shift assignments and secondary structure prediction of the C-terminal domain of the response regulator BfmR from Acinetobacter baumannii. Biomol NMR Assign. 2014 Apr; 8(1):67-70. PMID: 23264007.
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    16. Thompson RJ, Bobay BG, Stowe SD, Olson AL, Peng L, Su Z, Actis LA, Melander C, Cavanagh J. Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent. Biochemistry. 2012 Dec 11; 51(49):9776-8. PMID: 23186243.
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    17. Bobay BG, Stewart AL, Tucker AT, Thompson RJ, Varney KM, Cavanagh J. Structural insights into the calcium-dependent interaction between calbindin-D28K and caspase-3. FEBS Lett. 2012 Oct 19; 586(20):3582-9. PMID: 22982862.
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    18. Bobay BG, Hoch JA, Cavanagh J. Dynamics and activation in response regulators: the ß4-a4 loop. Biomol Concepts. 2012 Feb 01; 3(2):175-182. PMID: 24494032.
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    19. Stowe SD, Tucker AT, Thompson R, Piper A, Richards JJ, Rogers SA, Mathies LD, Melander C, Cavanagh J. Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems. Drug Chem Toxicol. 2012 Jul; 35(3):310-5. PMID: 22292413.
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    20. Stowe SD, Richards JJ, Tucker AT, Thompson R, Melander C, Cavanagh J. Anti-biofilm compounds derived from marine sponges. Mar Drugs. 2011; 9(10):2010-35. PMID: 22073007.
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    21. Olson AL, Bobay BG, Melander C, Cavanagh J. ¹H, ¹³C, and ¹5N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis. Biomol NMR Assign. 2012 Apr; 6(1):95-8. PMID: 21845362.
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    22. Bobay BG, Thompson RJ, Hoch JA, Cavanagh J. Long range dynamic effects of point-mutations trap a response regulator in an active conformation. FEBS Lett. 2010 Oct 08; 584(19):4203-7. PMID: 20828564.
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    23. Yang H, Gurgel PV, Williams DK, Bobay BG, Cavanagh J, Muddiman DC, Carbonell RG. Binding site on human immunoglobulin G for the affinity ligand HWRGWV. J Mol Recognit. 2010 May-Jun; 23(3):271-82. PMID: 20049844.
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    24. Hobbs CA, Bobay BG, Thompson RJ, Perego M, Cavanagh J. NMR solution structure and DNA-binding model of the DNA-binding domain of competence protein A. J Mol Biol. 2010 Apr 30; 398(2):248-63. PMID: 20302877.
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    25. Hobbs CA, Deterding LJ, Perera L, Bobay BG, Thompson RJ, Darden TA, Cavanagh J, Tomer KB. Structural characterization of the conformational change in calbindin-D28k upon calcium binding using differential surface modification analyzed by mass spectrometry. Biochemistry. 2009 Sep 15; 48(36):8603-14. PMID: 19658395.
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    26. Richards JJ, Reyes S, Stowe SD, Tucker AT, Ballard TE, Mathies LD, Cavanagh J, Melander C. Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity. J Med Chem. 2009 Aug 13; 52(15):4582-5. PMID: 19719234.
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    27. Kojetin DJ, McLaughlin PD, Thompson RJ, Dubnau D, Prepiak P, Rance M, Cavanagh J. Structural and motional contributions of the Bacillus subtilis ClpC N-domain to adaptor protein interactions. J Mol Biol. 2009 Apr 03; 387(3):639-52. PMID: 19361434.
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    28. Sullivan DM, Bobay BG, Kojetin DJ, Thompson RJ, Rance M, Strauch MA, Cavanagh J. Insights into the nature of DNA binding of AbrB-like transcription factors. Structure. 2008 Nov 12; 16(11):1702-13. PMID: 19000822.
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    29. Szurmant H, Bobay BG, White RA, Sullivan DM, Thompson RJ, Hwa T, Hoch JA, Cavanagh J. Co-evolving motions at protein-protein interfaces of two-component signaling systems identified by covariance analysis. Biochemistry. 2008 Jul 29; 47(30):7782-4. PMID: 18588317.
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    30. Burns VA, Bobay BG, Basso A, Cavanagh J, Melander C. Targeting RNA with cysteine-constrained peptides. Bioorg Med Chem Lett. 2008 Jan 15; 18(2):565-7. PMID: 18065222.
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    31. Kordys DR, Bobay BG, Thompson RJ, Venters RA, Cavanagh J. Peptide binding proclivities of calcium loaded calbindin-D28k. FEBS Lett. 2007 Oct 02; 581(24):4778-82. PMID: 17880944.
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    32. Kojetin DJ, McLaughlin PD, Thompson RJ, Venters RA, Rance M, Cavanagh J. NMR assignment of the N-terminal repeat domain of Bacillus subtilis ClpC. Biomol NMR Assign. 2007 Dec; 1(2):163-5. PMID: 19636855.
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    33. Strauch MA, Bobay BG, Cavanagh J, Yao F, Wilson A, Le Breton Y. Abh and AbrB control of Bacillus subtilis antimicrobial gene expression. J Bacteriol. 2007 Nov; 189(21):7720-32. PMID: 17720793.
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    34. McLaughlin PD, Bobay BG, Regel EJ, Thompson RJ, Hoch JA, Cavanagh J. Predominantly buried residues in the response regulator Spo0F influence specific sensor kinase recognition. FEBS Lett. 2007 Apr 03; 581(7):1425-9. PMID: 17350627.
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    35. Kojetin DJ, Sullivan DM, Thompson RJ, Cavanagh J. Classification of response regulators based on their surface properties. Methods Enzymol. 2007; 422:141-69. PMID: 17628138.
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    36. Soderblom EJ, Bobay BG, Cavanagh J, Goshe MB. Tandem mass spectrometry acquisition approaches to enhance identification of protein-protein interactions using low-energy collision-induced dissociative chemical crosslinking reagents. Rapid Commun Mass Spectrom. 2007; 21(21):3395-408. PMID: 17902198.
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    37. Kojetin DJ, Venters RA, Kordys DR, Thompson RJ, Kumar R, Cavanagh J. Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D(28K). Nat Struct Mol Biol. 2006 Jul; 13(7):641-7. PMID: 16799559.
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    38. Bobay BG, Mueller GA, Thompson RJ, Murzin AG, Venters RA, Strauch MA, Cavanagh J. NMR structure of AbhN and comparison with AbrBN: FIRST insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins. J Biol Chem. 2006 Jul 28; 281(30):21399-21409. PMID: 16702211.
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    39. Bobay BG, Andreeva A, Mueller GA, Cavanagh J, Murzin AG. Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins. FEBS Lett. 2005 Oct 24; 579(25):5669-74. PMID: 16223496.
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    40. Kojetin DJ, Thompson RJ, Benson LM, Naylor S, Waterman J, Davies KG, Opperman CH, Stephenson K, Hoch JA, Cavanagh J. Structural analysis of divalent metals binding to the Bacillus subtilis response regulator Spo0F: the possibility for in vitro metalloregulation in the initiation of sporulation. Biometals. 2005 Oct; 18(5):449-66. PMID: 16333746.
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    41. Ulrich DL, Kojetin D, Bassler BL, Cavanagh J, Loria JP. Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing. J Mol Biol. 2005 Mar 25; 347(2):297-307. PMID: 15740742.
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    42. Bobay BG, Benson L, Naylor S, Feeney B, Clark AC, Goshe MB, Strauch MA, Thompson R, Cavanagh J. Evaluation of the DNA binding tendencies of the transition state regulator AbrB. Biochemistry. 2004 Dec 28; 43(51):16106-18. PMID: 15610005.
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    43. Ulrich DL, Thompson R, Bassler B, Cavanagh J, Loria JP. 1H, 15N, and 13C chemical shift assignments of the Vibrio harveyi histidine phosphotransferase protein LuxU. J Biomol NMR. 2004 Aug; 29(4):551-2. PMID: 15243194.
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    44. Kojetin DJ, Thompson RJ, Cavanagh J. Sub-classification of response regulators using the surface characteristics of their receiver domains. FEBS Lett. 2003 Nov 20; 554(3):231-6. PMID: 14623071.
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    45. Cavanagh J, Benson LM, Thompson R, Naylor S. In line desalting mass spectrometry for the study of noncovalent biological complexes. Anal Chem. 2003 Jul 15; 75(14):3281-6. PMID: 14570174.
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    46. Venters RA, Benson LM, Craig TA, Bagu J, Paul KH, Kordys DR, Thompson R, Naylor S, Kumar R, Cavanagh J. The effects of Ca(2+) binding on the conformation of calbindin D(28K): a nuclear magnetic resonance and microelectrospray mass spectrometry study. Anal Biochem. 2003 Jun 01; 317(1):59-66. PMID: 12729601.
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    47. Lutz W, Frank EM, Craig TA, Thompson R, Venters RA, Kojetin D, Cavanagh J, Kumar R. Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy. Biochem Biophys Res Commun. 2003 Apr 18; 303(4):1186-92. PMID: 12684061.
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    48. Benson LM, Vaughn JL, Strauch MA, Bobay BG, Thompson R, Naylor S, Cavanagh J. Macromolecular assembly of the transition state regulator AbrB in its unbound and complexed states probed by microelectrospray ionization mass spectrometry. Anal Biochem. 2002 Jul 15; 306(2):222-7. PMID: 12123659.
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    49. Cavanagh J, Thompson R, Bobay B, Benson LM, Naylor S. Stoichiometries of protein-protein/DNA binding and conformational changes for the transition-state regulator AbrB measured by pseudo cell-size exclusion chromatography-mass spectrometry. Biochemistry. 2002 Jun 25; 41(25):7859-65. PMID: 12069574.
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