Last Name

Je-hyun Yoon

InstitutionMedical University of South Carolina
DepartmentBiochemistry and Molecular Biology
AddressP.O. Box MSC 509
Basic Science Building - 173 Ashley Ave.
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    Collapse Biography 
    Collapse awards and honors
    2013 - 2013RNA Society Scaringe Awards, RNA Society

    Collapse Overview 
    Collapse overview
    My main research interest is to understand the “RNP Code”, that is, the composition and function of RNA-binding proteins bound to RNAs, both coding and noncoding. I have contributed to efforts to characterize the assembly, composition, and function of ribonucleoprotein (RNP) particles, the influence of long noncoding (lnc)RNAs in translation and ubiquitin-mediated proteolysis, and the mechanisms that determine lncRNA abundance in the cell. I am interested in elucidating the rules that govern the assembly of RBPs into RNA-containing functional complexes, the influence of signaling events that regulate RNPs, and the impact of specific RBPs and RNAs on RNP activity and ensuing gene regulation. I am particularly interested in studying the consequences of RNPs on cellular events such as proliferation, survival, senescence, aging, and age-associated human diseases such as cancer. In my laboratory, I will strive to understand the role of RNPs in human physiology and in disease processes.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yoon JH, Gorospe M. Cross-Linking Immunoprecipitation and qPCR (CLIP-qPCR) Analysis to Map Interactions Between Long Noncoding RNAs and RNA-Binding Proteins. Methods Mol Biol. 2016; 1402:11-17. PMID: 26721479.
      View in: PubMed
    2. Yoon JH, Gorospe M. Identification of mRNA-Interacting Factors by MS2-TRAP (MS2-Tagged RNA Affinity Purification). Methods Mol Biol. 2016; 1421:15-22. PMID: 26965253.
      View in: PubMed
    3. Thompson KN, Whipple RA, Yoon JR, Lipsky M, Charpentier MS, Boggs AE, Chakrabarti KR, Bhandary L, Hessler LK, Martin SS, Vitolo MI. The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence. Oncotarget. 2015 Nov 03; 6(34):35231-46. PMID: 26497685.
      View in: PubMed
    4. Yoon JH, Jo MH, White EJ, De S, Hafner M, Zucconi BE, Abdelmohsen K, Martindale JL, Yang X, Wood WH, Shin YM, Song JJ, Tuschl T, Becker KG, Wilson GM, Hohng S, Gorospe M. AUF1 promotes let-7b loading on Argonaute 2. Genes Dev. 2015 Aug 01; 29(15):1599-604. PMID: 26253535.
      View in: PubMed
    5. Yoon JH, Kim J, Gorospe M. Long noncoding RNA turnover. Biochimie. 2015 Oct; 117:15-21. PMID: 25769416.
      View in: PubMed
    6. Yoon JH, De S, Srikantan S, Abdelmohsen K, Grammatikakis I, Kim J, Kim KM, Noh JH, White EJ, Martindale JL, Yang X, Kang MJ, Wood WH, Noren Hooten N, Evans MK, Becker KG, Tripathi V, Prasanth KV, Wilson GM, Tuschl T, Ingolia NT, Hafner M, Gorospe M. PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity. Nat Commun. 2014 Nov 04; 5:5248. PMID: 25366541.
      View in: PubMed
    7. Yoon JH, Abdelmohsen K, Gorospe M. Functional interactions among microRNAs and long noncoding RNAs. Semin Cell Dev Biol. 2014 Oct; 34:9-14. PMID: 24965208.
      View in: PubMed
    8. Yoon JH, Gorospe M. Ribonucleoprotein therapy in Alzheimer's disease? Aging (Albany NY). 2014 Jun; 6(6):428-9. PMID: 25011426.
      View in: PubMed
    9. Yoon JH, Abdelmohsen K, Srikantan S, Guo R, Yang X, Martindale JL, Gorospe M. Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs. Nucleic Acids Res. 2014 Jan; 42(2):1196-208. PMID: 24106086.
      View in: PubMed
    10. Yoon JH, Abdelmohsen K, Kim J, Yang X, Martindale JL, Tominaga-Yamanaka K, White EJ, Orjalo AV, Rinn JL, Kreft SG, Wilson GM, Gorospe M. Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. Nat Commun. 2013; 4:2939. PMID: 24326307.
      View in: PubMed
    11. Yoon JH, Abdelmohsen K, Gorospe M. Posttranscriptional gene regulation by long noncoding RNA. J Mol Biol. 2013 Oct 09; 425(19):3723-30. PMID: 23178169.
      View in: PubMed
    12. Yoon JH, Abdelmohsen K, Srikantan S, Yang X, Martindale JL, De S, Huarte M, Zhan M, Becker KG, Gorospe M. LincRNA-p21 suppresses target mRNA translation. Mol Cell. 2012 Aug 24; 47(4):648-55. PMID: 22841487.
      View in: PubMed
    13. Yoon JH, Srikantan S, Gorospe M. MS2-TRAP (MS2-tagged RNA affinity purification): tagging RNA to identify associated miRNAs. Methods. 2012 Oct; 58(2):81-7. PMID: 22813890.
      View in: PubMed
    14. Whipple RA, Matrone MA, Cho EH, Balzer EM, Vitolo MI, Yoon JR, Ioffe OB, Tuttle KC, Yang J, Martin SS. Epithelial-to-mesenchymal transition promotes tubulin detyrosination and microtentacles that enhance endothelial engagement. Cancer Res. 2010 Oct 15; 70(20):8127-37. PMID: 20924103.
      View in: PubMed
    15. Yoon JH, Choi EJ, Parker R. Dcp2 phosphorylation by Ste20 modulates stress granule assembly and mRNA decay in Saccharomyces cerevisiae. J Cell Biol. 2010 May 31; 189(5):813-27. PMID: 20513766.
      View in: PubMed
    16. Yoon JH, Parker R. Coil-in-to snRNP assembly and Cajal bodies. Nat Struct Mol Biol. 2010 Apr; 17(4):391-3. PMID: 20368721.
      View in: PubMed
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