Stephen P. Ethier

TitleDirector of the Center for Genomic Medicine
InstitutionMedical University of South Carolina
DepartmentPathology and Laboratory Medicine
AddressP.O. Box MSC 908
BE412
68 President St.
Phone843-876-2537
Fax843-792-0368
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ethier SP, Guest ST, Garrett-Mayer E, Armeson K, Wilson RC, Duchinski K, Couch D, Gray JW, Kappler C. Development and implementation of the SUM breast cancer cell line functional genomics knowledge base. NPJ Breast Cancer. 2020; 6:30. PMID: 32715085.
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    2. Giordano A, Liu Y, Armeson K, Park Y, Ridinger M, Erlander M, Reuben J, Britten C, Kappler C, Yeh E, Ethier S. Polo-like kinase 1 (Plk1) inhibition synergizes with taxanes in triple negative breast cancer. PLoS One. 2019; 14(11):e0224420. PMID: 31751384.
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    3. Rutkovsky AC, Yeh ES, Guest ST, Findlay VJ, Muise-Helmericks RC, Armeson K, Ethier SP. Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer. BMC Cancer. 2019 May 23; 19(1):491. PMID: 31122207.
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    4. Homer-Bouthiette C, Zhao Y, Shunkwiler LB, Van Peel B, Garrett-Mayer E, Baird RC, Rissman AI, Guest ST, Ethier SP, John MC, Powers PA, Haag JD, Gould MN, Smits BMG. Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models. BMC Cancer. 2018 Dec 10; 18(1):1233. PMID: 30526553.
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    5. Carrell RK, Stanton RA, Ethier SP, LaRue AC, Soloff AC. ICOSL-augmented adenoviral-based vaccination induces a bipolar Th17/Th1 T cell response against unglycosylated MUC1 antigen. Vaccine. 2018 10 08; 36(42):6262-6269. PMID: 30219366.
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    6. Sun B, Wang G, Liu H, Liu P, Twal WO, Cheung H, Carroll SL, Ethier SP, Mevers EE, Clardy J, Roberts T, Chen C, Li Q, Wang L, Yang M, Zhao JJ, Wang Q. Oridonin inhibits aberrant AKT activation in breast cancer. Oncotarget. 2018 May 08; 9(35):23878-23889. PMID: 29844859.
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    7. Yang A, Qin S, Schulte BA, Ethier SP, Tew KD, Wang GY. MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer. Cancer Res. 2017 12 01; 77(23):6641-6650. PMID: 28951456.
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    8. Turner-Ivey B, Smith EL, Rutkovsky AC, Spruill LS, Mills JN, Ethier SP. Development of mammary hyperplasia, dysplasia, and invasive ductal carcinoma in transgenic mice expressing the 8p11 amplicon oncogene NSD3. Breast Cancer Res Treat. 2017 Jul; 164(2):349-358. PMID: 28484924.
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    9. Allaoui R, Bergenfelz C, Mohlin S, Hagerling C, Salari K, Werb Z, Anderson RL, Ethier SP, Jirström K, Påhlman S, Bexell D, Tahin B, Johansson ME, Larsson C, Leandersson K. Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers. Nat Commun. 2016 10 11; 7:13050. PMID: 27725631.
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    10. Guest ST, Kratche ZR, Irish JC, Wilson RC, Haddad R, Gray JW, Garrett-Mayer E, Ethier SP. Functional oncogene signatures guide rationally designed combination therapies to synergistically induce breast cancer cell death. Oncotarget. 2016 Jun 14; 7(24):36138-36153. PMID: 27153554.
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    11. Cichon MA, Moruzzi ME, Shqau TA, Miller E, Mehner C, Ethier SP, Copland JA, Radisky ES, Radisky DC. MYC Is a Crucial Mediator of TGFß-Induced Invasion in Basal Breast Cancer. Cancer Res. 2016 06 15; 76(12):3520-30. PMID: 27197167.
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    12. Irish JC, Mills JN, Turner-Ivey B, Wilson RC, Guest ST, Rutkovsky A, Dombkowski A, Kappler CS, Hardiman G, Ethier SP. Amplification of WHSC1L1 regulates expression and estrogen-independent activation of ERa in SUM-44 breast cancer cells and is associated with ERa over-expression in breast cancer. Mol Oncol. 2016 06; 10(6):850-65. PMID: 27005559.
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    13. Duckworth C, Zhang L, Carroll SL, Ethier SP, Cheung HW. Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression. Oncogene. 2016 08 04; 35(31):4036-47. PMID: 26657155.
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    14. Freedman LP, Gibson MC, Wisman R, Ethier SP, Soule HR, Reid YA, Neve RM. The culture of cell culture practices and authentication--Results from a 2015 Survey. Biotechniques. 2015 Oct; 59(4):189-90, 192. PMID: 26458546.
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    15. Mehmeti M, Allaoui R, Bergenfelz C, Saal LH, Ethier SP, Johansson ME, Jirström K, Leandersson K. Expression of functional toll like receptor 4 in estrogen receptor/progesterone receptor-negative breast cancer. Breast Cancer Res. 2015 Sep 22; 17:130. PMID: 26392082.
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    16. Freedman LP, Gibson MC, Ethier SP, Soule HR, Neve RM, Reid YA. Reproducibility: changing the policies and culture of cell line authentication. Nat Methods. 2015 Jun; 12(6):493-7. PMID: 26020501.
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    17. Williams CB, Soloff AC, Ethier SP, Yeh ES. Perspectives on Epidermal Growth Factor Receptor Regulation in Triple-Negative Breast Cancer: Ligand-Mediated Mechanisms of Receptor Regulation and Potential for Clinical Targeting. Adv Cancer Res. 2015; 127:253-81. PMID: 26093903.
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    18. Guest ST, Kratche ZR, Bollig-Fischer A, Haddad R, Ethier SP. Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes. Exp Cell Res. 2015 Mar 15; 332(2):223-35. PMID: 25704758.
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    19. Kappler CS, Guest ST, Irish JC, Garrett-Mayer E, Kratche Z, Wilson RC, Ethier SP. Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast cancer. Mol Oncol. 2015 Feb; 9(2):527-43. PMID: 25454348.
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    20. Findlay VJ, Wang C, Nogueira LM, Hurst K, Quirk D, Ethier SP, Staveley O'Carroll KF, Watson DK, Camp ER. SNAI2 modulates colorectal cancer 5-fluorouracil sensitivity through miR145 repression. . 2014 Nov; 13(11):2713-26. PMID: 25249558.
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    21. Turner-Ivey B, Guest ST, Irish JC, Kappler CS, Garrett-Mayer E, Wilson RC, Ethier SP. KAT6A, a chromatin modifier from the 8p11-p12 amplicon is a candidate oncogene in luminal breast cancer. Neoplasia. 2014 Aug; 16(8):644-55. PMID: 25220592.
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    22. Timmerman LA, Holton T, Yuneva M, Louie RJ, Padró M, Daemen A, Hu M, Chan DA, Ethier SP, van 't Veer LJ, Polyak K, McCormick F, Gray JW. Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell. 2013 Oct 14; 24(4):450-65. PMID: 24094812.
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    23. Holm K, Grabau D, Lövgren K, Aradottir S, Gruvberger-Saal S, Howlin J, Saal LH, Ethier SP, Bendahl PO, Stål O, Malmström P, Fernö M, Rydén L, Hegardt C, Borg Å, Ringnér M. Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes. Mol Oncol. 2012 Oct; 6(5):494-506. PMID: 22766277.
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    24. Wang G, Liu G, Wang X, Sethi S, Ali-Fehmi R, Abrams J, Zheng Z, Zhang K, Ethier S, Yang ZQ. ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways. BMC Cancer. 2012 Jun 08; 12:225. PMID: 22681620.
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    25. Piechocki MP, Wu GS, Jones RF, Jacob JB, Gibson H, Ethier SP, Abrams J, Yagita H, Venuprasad K, Wei WZ. Induction of proapoptotic antibodies to triple-negative breast cancer by vaccination with TRAIL death receptor DR5 DNA. Int J Cancer. 2012 Dec 01; 131(11):2562-72. PMID: 22419388.
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    26. Baillo A, Giroux C, Ethier SP. Knock-down of amphiregulin inhibits cellular invasion in inflammatory breast cancer. J Cell Physiol. 2011 Oct; 226(10):2691-701. PMID: 21302279.
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    27. Fackler MJ, Umbricht CB, Williams D, Argani P, Cruz LA, Merino VF, Teo WW, Zhang Z, Huang P, Visvananthan K, Marks J, Ethier S, Gray JW, Wolff AC, Cope LM, Sukumar S. Genome-wide methylation analysis identifies genes specific to breast cancer hormone receptor status and risk of recurrence. Cancer Res. 2011 Oct 01; 71(19):6195-207. PMID: 21825015.
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    28. Wu J, Liu S, Liu G, Dombkowski A, Abrams J, Martin-Trevino R, Wicha MS, Ethier SP, Yang ZQ. Identification and functional analysis of 9p24 amplified genes in human breast cancer. Oncogene. 2012 Jan 19; 31(3):333-41. PMID: 21666724.
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    29. Bollig-Fischer A, Dewey TG, Ethier SP. Oncogene activation induces metabolic transformation resulting in insulin-independence in human breast cancer cells. PLoS One. 2011 Mar 17; 6(3):e17959. PMID: 21437235.
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    30. Cote ML, Haddad R, Edwards DJ, Atikukke G, Gadgeel S, Soubani AO, Lonardo F, Bepler G, Schwartz AG, Ethier SP. Frequency and type of epidermal growth factor receptor mutations in African Americans with non-small cell lung cancer. J Thorac Oncol. 2011 Mar; 6(3):627-30. PMID: 21317742.
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    31. Zhang H, Meng F, Liu G, Zhang B, Zhu J, Wu F, Ethier SP, Miller F, Wu G. Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis. Cancer Res. 2011 Feb 15; 71(4):1292-301. PMID: 21285253.
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    32. Yang ZQ, Liu G, Bollig-Fischer A, Giroux CN, Ethier SP. Transforming properties of 8p11-12 amplified genes in human breast cancer. Cancer Res. 2010 Nov 01; 70(21):8487-97. PMID: 20940404.
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    33. Bollig-Fischer A, Dziubinski M, Boyer A, Haddad R, Giroux CN, Ethier SP. HER-2 signaling, acquisition of growth factor independence, and regulation of biological networks associated with cell transformation. Cancer Res. 2010 Oct 15; 70(20):7862-73. PMID: 20736364.
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    34. Mueller KL, Yang ZQ, Haddad R, Ethier SP, Boerner JL. EGFR/Met association regulates EGFR TKI resistance in breast cancer. J Mol Signal. 2010 Jul 12; 5:8. PMID: 20624308.
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    35. Zhang H, Chen D, Ringler J, Chen W, Cui QC, Ethier SP, Dou QP, Wu G. Disulfiram treatment facilitates phosphoinositide 3-kinase inhibition in human breast cancer cells in vitro and in vivo. Cancer Res. 2010 May 15; 70(10):3996-4004. PMID: 20424113.
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    36. Yang ZQ, Liu G, Bollig-Fischer A, Haddad R, Tarca AL, Ethier SP. Methylation-associated silencing of SFRP1 with an 8p11-12 amplification inhibits canonical and non-canonical WNT pathways in breast cancers. Int J Cancer. 2009 Oct 01; 125(7):1613-21. PMID: 19569235.
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    37. Liu G, Bollig-Fischer A, Kreike B, van de Vijver MJ, Abrams J, Ethier SP, Yang ZQ. Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer. Oncogene. 2009 Dec 17; 28(50):4491-500. PMID: 19784073.
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    38. Hollestelle A, Nagel JH, Smid M, Lam S, Elstrodt F, Wasielewski M, Ng SS, French PJ, Peeters JK, Rozendaal MJ, Riaz M, Koopman DG, Ten Hagen TL, de Leeuw BH, Zwarthoff EC, Teunisse A, van der Spek PJ, Klijn JG, Dinjens WN, Ethier SP, Clevers H, Jochemsen AG, den Bakker MA, Foekens JA, Martens JW, Schutte M. Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines. Breast Cancer Res Treat. 2010 May; 121(1):53-64. PMID: 19593635.
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    39. Arias-Romero LE, Saha S, Villamar-Cruz O, Yip SC, Ethier SP, Zhang ZY, Chernoff J. Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. Cancer Res. 2009 Jun 01; 69(11):4582-8. PMID: 19435911.
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    40. Lippman ME, Ethier S, Hayes DF. Editorial: Cost-effective analyses in Breast Cancer Research and Treatment [corrected]. Breast Cancer Res Treat. 2009 May; 115(2):221-2. PMID: 19449205.
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    41. Balan V, Nangia-Makker P, Schwartz AG, Jung YS, Tait L, Hogan V, Raz T, Wang Y, Yang ZQ, Wu GS, Guo Y, Li H, Abrams J, Couch FJ, Lingle WL, Lloyd RV, Ethier SP, Tainsky MA, Raz A. Racial disparity in breast cancer and functional germ line mutation in galectin-3 (rs4644): a pilot study. Cancer Res. 2008 Dec 15; 68(24):10045-50. PMID: 19074869.
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    42. Riggins RB, Lan JP, Zhu Y, Klimach U, Zwart A, Cavalli LR, Haddad BR, Chen L, Gong T, Xuan J, Ethier SP, Clarke R. ERRgamma mediates tamoxifen resistance in novel models of invasive lobular breast cancer. Cancer Res. 2008 Nov 01; 68(21):8908-17. PMID: 18974135.
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    43. Willmarth NE, Baillo A, Dziubinski ML, Wilson K, Riese DJ, Ethier SP. Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop. Cell Signal. 2009 Feb; 21(2):212-9. PMID: 18951974.
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    44. Mueller KL, Hunter LA, Ethier SP, Boerner JL. Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells. Cancer Res. 2008 May 01; 68(9):3314-22. PMID: 18451158.
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    45. Willmarth NE, Ethier SP. Amphiregulin as a novel target for breast cancer therapy. J Mammary Gland Biol Neoplasia. 2008 Jun; 13(2):171-9. PMID: 18437539.
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    46. Wasielewski M, Hanifi-Moghaddam P, Hollestelle A, Merajver SD, van den Ouweland A, Klijn JG, Ethier SP, Schutte M. Deleterious CHEK2 1100delC and L303X mutants identified among 38 human breast cancer cell lines. Breast Cancer Res Treat. 2009 Jan; 113(2):285-91. PMID: 18297428.
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    47. Zhang H, Liu G, Dziubinski M, Yang Z, Ethier SP, Wu G. Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells. Breast Cancer Res Treat. 2008 Nov; 112(2):217-27. PMID: 18074223.
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    48. Saal LH, Gruvberger-Saal SK, Persson C, Lövgren K, Jumppanen M, Staaf J, Jönsson G, Pires MM, Maurer M, Holm K, Koujak S, Subramaniyam S, Vallon-Christersson J, Olsson H, Su T, Memeo L, Ludwig T, Ethier SP, Krogh M, Szabolcs M, Murty VV, Isola J, Hibshoosh H, Parsons R, Borg A. Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat Genet. 2008 Jan; 40(1):102-7. PMID: 18066063.
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    49. Draghici S, Tarca AL, Yu L, Ethier S, Romero R. KUTE-BASE: storing, downloading and exporting MIAME-compliant microarray experiments in minutes rather than hours. Bioinformatics. 2008 Mar 01; 24(5):738-40. PMID: 18024967.
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    50. Yang ZQ, Moffa AB, Haddad R, Streicher KL, Ethier SP. Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways. Int J Cancer. 2007 Sep 15; 121(6):1265-73. PMID: 17520678.
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    51. Streicher KL, Willmarth NE, Garcia J, Boerner JL, Dewey TG, Ethier SP. Activation of a nuclear factor kappaB/interleukin-1 positive feedback loop by amphiregulin in human breast cancer cells. Mol Cancer Res. 2007 Aug; 5(8):847-61. PMID: 17670913.
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    52. Diehl KM, Grewal N, Ethier SP, Woods-Ignatoski KM. p38MAPK-activated AKT in HER-2 overexpressing human breast cancer cells acts as an EGF-independent survival signal. J Surg Res. 2007 Sep; 142(1):162-9. PMID: 17612563.
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    53. Wu G, Guo Z, Chang X, Kim MS, Nagpal JK, Liu J, Maki JM, Kivirikko KI, Ethier SP, Trink B, Sidransky D. LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer. Cancer Res. 2007 May 01; 67(9):4123-9. PMID: 17456585.
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    54. Moffa AB, Ethier SP. Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells. J Cell Physiol. 2007 Mar; 210(3):720-31. PMID: 17133345.
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    55. Yang ZQ, Streicher KL, Ray ME, Abrams J, Ethier SP. Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer. Cancer Res. 2006 Dec 15; 66(24):11632-43. PMID: 17178857.
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    56. Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, Speed T, Spellman PT, DeVries S, Lapuk A, Wang NJ, Kuo WL, Stilwell JL, Pinkel D, Albertson DG, Waldman FM, McCormick F, Dickson RB, Johnson MD, Lippman M, Ethier S, Gazdar A, Gray JW. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell. 2006 Dec; 10(6):515-27. PMID: 17157791.
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    57. Willmarth NE, Ethier SP. Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells. J Biol Chem. 2006 Dec 08; 281(49):37728-37. PMID: 17035230.
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    58. Streicher KL, Yang ZQ, Draghici S, Ethier SP. Transforming function of the LSM1 oncogene in human breast cancers with the 8p11-12 amplicon. Oncogene. 2007 Mar 29; 26(14):2104-14. PMID: 17001308.
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    59. Hayes DF, Ethier S, Lippman ME. New guidelines for reporting of tumor marker studies in breast cancer research and treatment: REMARK. Breast Cancer Res Treat. 2006 Nov; 100(2):237-8. PMID: 16773436.
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    60. Pal M, Moffa A, Sreekumar A, Ethier SP, Barder TJ, Chinnaiyan A, Lubman DM. Differential phosphoprotein mapping in cancer cells using protein microarrays produced from 2-D liquid fractionation. Anal Chem. 2006 Feb 01; 78(3):702-10. PMID: 16448042.
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    61. Elstrodt F, Hollestelle A, Nagel JH, Gorin M, Wasielewski M, van den Ouweland A, Merajver SD, Ethier SP, Schutte M. BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants. Cancer Res. 2006 Jan 01; 66(1):41-5. PMID: 16397213.
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    62. Gelsi-Boyer V, Orsetti B, Cervera N, Finetti P, Sircoulomb F, Rougé C, Lasorsa L, Letessier A, Ginestier C, Monville F, Esteyriès S, Adélaïde J, Esterni B, Henry C, Ethier SP, Bibeau F, Mozziconacci MJ, Charafe-Jauffret E, Jacquemier J, Bertucci F, Birnbaum D, Theillet C, Chaffanet M. Comprehensive profiling of 8p11-12 amplification in breast cancer. Mol Cancer Res. 2005 Dec; 3(12):655-67. PMID: 16380503.
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    63. Woods Ignatoski KM, Dziubinski ML, Ammerman C, Ethier SP. Cooperative interactions of HER-2 and HPV-16 oncoproteins in the malignant transformation of human mammary epithelial cells. Neoplasia. 2005 Aug; 7(8):788-98. PMID: 16207481.
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    64. Berquin IM, Pang B, Dziubinski ML, Scott LM, Chen YQ, Nolan GP, Ethier SP. Y-box-binding protein 1 confers EGF independence to human mammary epithelial cells. Oncogene. 2005 Apr 28; 24(19):3177-86. PMID: 15735691.
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    65. Jia Y, Zeng ZZ, Markwart SM, Rockwood KF, Ignatoski KM, Ethier SP, Livant DL. Integrin fibronectin receptors in matrix metalloproteinase-1-dependent invasion by breast cancer and mammary epithelial cells. Cancer Res. 2004 Dec 01; 64(23):8674-81. PMID: 15574776.
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    66. Yang ZQ, Albertson D, Ethier SP. Genomic organization of the 8p11-p12 amplicon in three breast cancer cell lines. Cancer Genet Cytogenet. 2004 Nov; 155(1):57-62. PMID: 15527903.
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    67. Moffa AB, Tannheimer SL, Ethier SP. Transforming potential of alternatively spliced variants of fibroblast growth factor receptor 2 in human mammary epithelial cells. Mol Cancer Res. 2004 Nov; 2(11):643-52. PMID: 15561780.
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    68. Rios-Doria J, Kuefer R, Ethier SP, Day ML. Cleavage of beta-catenin by calpain in prostate and mammary tumor cells. Cancer Res. 2004 Oct 15; 64(20):7237-40. PMID: 15492240.
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    69. Willmarth NE, Albertson DG, Ethier SP. Chromosomal instability and lack of cyclin E regulation in hCdc4 mutant human breast cancer cells. Breast Cancer Res. 2004; 6(5):R531-9. PMID: 15318934.
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    70. Song H, Ethier SP, Dziubinski ML, Lin J. Stat3 modulates heat shock 27kDa protein expression in breast epithelial cells. Biochem Biophys Res Commun. 2004 Jan 30; 314(1):143-50. PMID: 14715258.
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    71. Nyati MK, Maheshwari D, Hanasoge S, Sreekumar A, Rynkiewicz SD, Chinnaiyan AM, Leopold WR, Ethier SP, Lawrence TS. Radiosensitization by pan ErbB inhibitor CI-1033 in vitro and in vivo. Clin Cancer Res. 2004 Jan 15; 10(2):691-700. PMID: 14760092.
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    72. Ray ME, Yang ZQ, Albertson D, Kleer CG, Washburn JG, Macoska JA, Ethier SP. Genomic and expression analysis of the 8p11-12 amplicon in human breast cancer cell lines. Cancer Res. 2004 Jan 01; 64(1):40-7. PMID: 14729606.
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    73. Woods Ignatoski KM, Livant DL, Markwart S, Grewal NK, Ethier SP. The role of phosphatidylinositol 3'-kinase and its downstream signals in erbB-2-mediated transformation. Mol Cancer Res. 2003 May; 1(7):551-60. PMID: 12754302.
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    74. Ethier SP. Identifying and validating causal genetic alterations in human breast cancer. Breast Cancer Res Treat. 2003 Apr; 78(3):285-7. PMID: 12755487.
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    75. Woods Ignatoski KM, Grewal NK, Markwart S, Livant DL, Ethier SP. p38MAPK induces cell surface alpha4 integrin downregulation to facilitate erbB-2-mediated invasion. Neoplasia. 2003 Mar-Apr; 5(2):128-34. PMID: 12659685.
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    76. Kumar-Sinha C, Ignatoski KW, Lippman ME, Ethier SP, Chinnaiyan AM. Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis. Cancer Res. 2003 Jan 01; 63(1):132-9. PMID: 12517789.
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    77. Popovici C, Basset C, Bertucci F, Orsetti B, Adélaide J, Mozziconacci MJ, Conte N, Murati A, Ginestier C, Charafe-Jauffret E, Ethier SP, Lafage-Pochitaloff M, Theillet C, Birnbaum D, Chaffanet M. Reciprocal translocations in breast tumor cell lines: cloning of a t(3;20) that targets the FHIT gene. Genes Chromosomes Cancer. 2002 Nov; 35(3):204-18. PMID: 12353263.
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    78. Billecke CA, Ljungman ME, McKay BC, Rehemtulla A, Taneja N, Ethier SP. Lack of functional pRb results in attenuated recovery of mRNA synthesis and increased apoptosis following UV radiation in human breast cancer cells. Oncogene. 2002 Jul 04; 21(29):4481-9. PMID: 12085226.
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    79. Ethier SP. Signal transduction pathways: the molecular basis for targeted therapies. Semin Radiat Oncol. 2002 Jul; 12(3 Suppl 2):3-10. PMID: 12174339.
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    80. Berquin IM, Dziubinski ML, Nolan GP, Ethier SP. A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin. Oncogene. 2001 Jul 05; 20(30):4019-28. PMID: 11494130.
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    81. Sartor CI, Zhou H, Kozlowska E, Guttridge K, Kawata E, Caskey L, Harrelson J, Hynes N, Ethier S, Calvo B, Earp HS. Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells. Mol Cell Biol. 2001 Jul; 21(13):4265-75. PMID: 11390655.
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    82. van Golen CM, Schwab TS, Ignatoski KM, Ethier SP, Feldman EL. PTEN/MMAC1 overexpression decreases insulin-like growth factor-I-mediated protection from apoptosis in neuroblastoma cells. Cell Growth Differ. 2001 Jul; 12(7):371-8. PMID: 11457734.
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    83. Zajchowski DA, Bartholdi MF, Gong Y, Webster L, Liu HL, Munishkin A, Beauheim C, Harvey S, Ethier SP, Johnson PH. Identification of gene expression profiles that predict the aggressive behavior of breast cancer cells. Cancer Res. 2001 Jul 01; 61(13):5168-78. PMID: 11431356.
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    84. Ethier SP, Lawrence TS. Epidermal growth factor receptor signaling and response of cancer cells to ionizing radiation. J Natl Cancer Inst. 2001 Jun 20; 93(12):890-1. PMID: 11416102.
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    85. Chong BE, Hamler RL, Lubman DM, Ethier SP, Rosenspire AJ, Miller FR. Differential screening and mass mapping of proteins from premalignant and cancer cell lines using nonporous reversed-phase HPLC coupled with mass spectrometric analysis. Anal Chem. 2001 Mar 15; 73(6):1219-27. PMID: 11305655.
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    86. Rao GS, Murray S, Ethier SP. Radiosensitization of human breast cancer cells by a novel ErbB family receptor tyrosine kinase inhibitor. Int J Radiat Oncol Biol Phys. 2000 Dec 01; 48(5):1519-28. PMID: 11121658.
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    87. Percy MJ, Myrie KA, Neeley CK, Azim JN, Ethier SP, Petty EM. Expression and mutational analyses of the human MAD2L1 gene in breast cancer cells. Genes Chromosomes Cancer. 2000 Dec; 29(4):356-62. PMID: 11066082.
      Citations:    
    88. Carlson CA, Ethier SP. Lack of RB protein correlates with increased sensitivity to UV-radiation-induced apoptosis in human breast cancer cells. Radiat Res. 2000 Nov; 154(5):590-9. PMID: 11025655.
      Citations:    
    89. Forozan F, Mahlamäki EH, Monni O, Chen Y, Veldman R, Jiang Y, Gooden GC, Ethier SP, Kallioniemi A, Kallioniemi OP. Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data. Cancer Res. 2000 Aug 15; 60(16):4519-25. PMID: 10969801.
      Citations:    
    90. Ram TG, Hosick HL, Ethier SP. Heregulin-beta is especially potent in activating phosphatidylinositol 3-kinase in nontransformed human mammary epithelial cells. J Cell Physiol. 2000 Jun; 183(3):301-13. PMID: 10797304.
      Citations:    
    91. Livant DL, Brabec RK, Kurachi K, Allen DL, Wu Y, Haaseth R, Andrews P, Ethier SP, Markwart S. The PHSRN sequence induces extracellular matrix invasion and accelerates wound healing in obese diabetic mice. J Clin Invest. 2000 Jun; 105(11):1537-45. PMID: 10841512.
      Citations:    
    92. Tannheimer SL, Rehemtulla A, Ethier SP. Characterization of fibroblast growth factor receptor 2 overexpression in the human breast cancer cell line SUM-52PE. Breast Cancer Res. 2000; 2(4):311-20. PMID: 11056689.
      Citations:    
    93. Sumantran VN, Lee DS, Woods Ignatoski KM, Ethier SP, Wicha MS. A bcl-xS adenovirus selectively induces apoptosis in transformed cells compared to normal mammary cells. Neoplasia. 2000 May-Jun; 2(3):251-60. PMID: 10935511.
      Citations:    
    94. Ignatoski KM, Maehama T, Markwart SM, Dixon JE, Livant DL, Ethier SP. ERBB-2 overexpression confers PI 3' kinase-dependent invasion capacity on human mammary epithelial cells. Br J Cancer. 2000 Feb; 82(3):666-74. PMID: 10682681.
      Citations:    
    95. Flanagan L, Van Weelden K, Ammerman C, Ethier SP, Welsh J. SUM-159PT cells: a novel estrogen independent human breast cancer model system. Breast Cancer Res Treat. 1999 Dec; 58(3):193-204. PMID: 10718481.
      Citations:    
    96. Forozan F, Veldman R, Ammerman CA, Parsa NZ, Kallioniemi A, Kallioniemi OP, Ethier SP. Molecular cytogenetic analysis of 11 new breast cancer cell lines. Br J Cancer. 1999 Dec; 81(8):1328-34. PMID: 10604729.
      Citations:    
    97. van Golen KL, Davies S, Wu ZF, Wang Y, Bucana CD, Root H, Chandrasekharappa S, Strawderman M, Ethier SP, Merajver SD. A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype. Clin Cancer Res. 1999 Sep; 5(9):2511-9. PMID: 10499627.
      Citations:    
    98. Ignatoski KM, Lapointe AJ, Radany EH, Ethier SP. erbB-2 overexpression in human mammary epithelial cells confers growth factor independence. Endocrinology. 1999 Aug; 140(8):3615-22. PMID: 10433219.
      Citations:    
    99. Axelson MD, Davis MA, Ethier SP, Lawrence TS. HPV16-E7 expression causes fluorodeoxyuridine-mediated radiosensitization in SW620 human colon cancer cells. Neoplasia. 1999 Jun; 1(2):177-82. PMID: 10933053.
      Citations:    
    100. Ignatoski KM, Ethier SP. Constitutive activation of pp125fak in newly isolated human breast cancer cell lines. Breast Cancer Res Treat. 1999 Mar; 54(2):173-82. PMID: 10424408.
      Citations:    
    101. Tannheimer SL, Ethier SP, Caldwell KK, Burchiel SW. Benzo[a]pyrene- and TCDD-induced alterations in tyrosine phosphorylation and insulin-like growth factor signaling pathways in the MCF-10A human mammary epithelial cell line. Carcinogenesis. 1998 Jul; 19(7):1291-7. PMID: 9683191.
      Citations:    
    102. Garcia R, Yu CL, Hudnall A, Catlett R, Nelson KL, Smithgall T, Fujita DJ, Ethier SP, Jove R. Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ. 1997 Dec; 8(12):1267-76. PMID: 9419415.
      Citations:    
    103. Xia L, Stoll SW, Liebert M, Ethier SP, Carey T, Esclamado R, Carroll W, Johnson TM, Elder JT. CaN19 expression in benign and malignant hyperplasias of the skin and oral mucosa: evidence for a role in regenerative differentiation. Cancer Res. 1997 Jul 15; 57(14):3055-62. PMID: 9230222.
      Citations:    
    104. Tannheimer SL, Barton SL, Ethier SP, Burchiel SW. Carcinogenic polycyclic aromatic hydrocarbons increase intracellular Ca2+ and cell proliferation in primary human mammary epithelial cells. Carcinogenesis. 1997 Jun; 18(6):1177-82. PMID: 9214600.
      Citations:    
    105. Sartor CI, Dziubinski ML, Yu CL, Jove R, Ethier SP. Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells. Cancer Res. 1997 Mar 01; 57(5):978-87. PMID: 9041204.
      Citations:    
    106. Aprelikova O, Kuthiala A, Bessho M, Ethier S, Liu ET. BRCA1 protein level is not affected by peptide growth factors in MCF10A cell line. Oncogene. 1996 Dec 05; 13(11):2487-91. PMID: 8957093.
      Citations:    
    107. Howe SR, Pass HI, Ethier SP, Matthews WJ, Walker C. Presence of an insulin-like growth factor I autocrine loop predicts uterine fibroid responsiveness to tamoxifen. Cancer Res. 1996 Sep 01; 56(17):4049-55. PMID: 8752178.
      Citations:    
    108. Rampy MA, Brown RS, Pinchuk AN, Weichert JP, Skinner RW, Fisher SJ, Wahl RL, Gross MD, Ethier SP, Counsell RE. Biological disposition and imaging of a radioiodinated alkylphosphocholine in two rodent models of breast cancer. J Nucl Med. 1996 Sep; 37(9):1540-5. PMID: 8790215.
      Citations:    
    109. Brown RS, Leung JY, Fisher SJ, Frey KA, Ethier SP, Wahl RL. Intratumoral distribution of tritiated-FDG in breast carcinoma: correlation between Glut-1 expression and FDG uptake. J Nucl Med. 1996 Jun; 37(6):1042-7. PMID: 8683298.
      Citations:    
    110. Ram TG, Ethier SP. Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplification. Cell Growth Differ. 1996 May; 7(5):551-61. PMID: 8732665.
      Citations:    
    111. Ram TG, Dilts CA, Dziubinski ML, Pierce LJ, Ethier SP. Insulin-like growth factor and epidermal growth factor independence in human mammary carcinoma cells with c-erbB-2 gene amplification and progressively elevated levels of tyrosine-phosphorylated p185erbB-2. Mol Carcinog. 1996 Mar; 15(3):227-38. PMID: 8597535.
      Citations:    
    112. Ethier SP, Kokeny KE, Ridings JW, Dilts CA. erbB family receptor expression and growth regulation in a newly isolated human breast cancer cell line. Cancer Res. 1996 Feb 15; 56(4):899-907. PMID: 8631031.
      Citations:    
    113. Ethier SP, Langton BC, Dilts CA. Growth factor-independent proliferation of rat mammary carcinoma cells by autocrine secretion of neu-differentiation factor/heregulin and transforming growth factor-alpha. Mol Carcinog. 1996 Feb; 15(2):134-43. PMID: 8599580.
      Citations:    
    114. Ethier SP. Human breast cancer cell lines as models of growth regulation and disease progression. J Mammary Gland Biol Neoplasia. 1996 Jan; 1(1):111-21. PMID: 10887484.
      Citations:    
    115. Raylman RR, Fisher SJ, Brown RS, Ethier SP, Wahl RL. Fluorine-18-fluorodeoxyglucose-guided breast cancer surgery with a positron-sensitive probe: validation in preclinical studies. J Nucl Med. 1995 Oct; 36(10):1869-74. PMID: 7562057.
      Citations:    
    116. Brown RS, Leung JY, Fisher SJ, Frey KA, Ethier SP, Wahl RL. Intratumoral distribution of tritiated fluorodeoxyglucose in breast carcinoma: I. Are inflammatory cells important? J Nucl Med. 1995 Oct; 36(10):1854-61. PMID: 7562055.
      Citations:    
    117. Ethier SP. Growth factor synthesis and human breast cancer progression. J Natl Cancer Inst. 1995 Jul 05; 87(13):964-73. PMID: 7629883.
      Citations:    
    118. Rachwal WJ, Bongiorno PF, Orringer MB, Whyte RI, Ethier SP, Beer DG. Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas. Br J Cancer. 1995 Jul; 72(1):56-64. PMID: 7599067.
      Citations:    
    119. Ram TG, Kokeny KE, Dilts CA, Ethier SP. Mitogenic activity of neu differentiation factor/heregulin mimics that of epidermal growth factor and insulin-like growth factor-I in human mammary epithelial cells. J Cell Physiol. 1995 Jun; 163(3):589-96. PMID: 7775601.
      Citations:    
    120. Rock CL, Kusluski RA, Galvez MM, Ethier SP. Carotenoids induce morphological changes in human mammary epithelial cell cultures. Nutr Cancer. 1995; 23(3):319-33. PMID: 7603892.
      Citations:    
    121. Datta YH, Adams PT, Drobyski WR, Ethier SP, Terry VH, Roth MS. Sensitive detection of occult breast cancer by the reverse-transcriptase polymerase chain reaction. J Clin Oncol. 1994 Mar; 12(3):475-82. PMID: 7509852.
      Citations:    
    122. Mahacek ML, Beer DG, Frank TS, Ethier SP. Finite proliferative lifespan in vitro of a human breast cancer cell strain isolated from a metastatic lymph node. Breast Cancer Res Treat. 1993 Dec; 28(3):267-76. PMID: 8018955.
      Citations:    
    123. Ethier SP, Taback E. Insulin like growth factor-I independence in rat mammary carcinoma cells: a dominant phenotype in somatic cell hybrid experiments. Cancer Lett. 1993 Nov 01; 74(3):189-95. PMID: 8174103.
      Citations:    
    124. Ethier SP, Mahacek ML, Gullick WJ, Frank TS, Weber BL. Differential isolation of normal luminal mammary epithelial cells and breast cancer cells from primary and metastatic sites using selective media. Cancer Res. 1993 Feb 01; 53(3):627-35. PMID: 8425198.
      Citations:    
    125. Wahl RL, Henry CA, Ethier SP. Serum glucose: effects on tumor and normal tissue accumulation of 2-[F-18]-fluoro-2-deoxy-D-glucose in rodents with mammary carcinoma. Radiology. 1992 Jun; 183(3):643-7. PMID: 1584912.
      Citations:    
    126. Ethier SP, Moorthy R, Dilts CA. Secretion of an epidermal growth factor-like growth factor by epidermal growth factor-independent rat mammary carcinoma cells. Cell Growth Differ. 1991 Nov; 2(11):593-602. PMID: 1726054.
      Citations:    
    127. Ethier SP, Moorthy R. Multiple growth factor independence in rat mammary carcinoma cells. Breast Cancer Res Treat. 1991 May; 18(2):73-81. PMID: 1912610.
      Citations:    
    128. Chiodino C, Jones RF, Ethier SP. The role of Ha-ras oncogenes in growth factor independence in rat mammary carcinoma cells. Mol Carcinog. 1991; 4(4):286-96. PMID: 1908245.
      Citations:    
    129. Ethier SP, Summerfelt RM, Cundiff KC, Asch BB. The influence of growth factors on the proliferative potential of normal and primary breast cancer-derived human breast epithelial cells. Breast Cancer Res Treat. 1991 Jan-Feb; 17(3):221-30. PMID: 1710154.
      Citations:    
    130. Wahl RL, Kaminski MS, Ethier SP, Hutchins GD. The potential of 2-deoxy-2[18F]fluoro-D-glucose (FDG) for the detection of tumor involvement in lymph nodes. J Nucl Med. 1990 Nov; 31(11):1831-5. PMID: 2230996.
      Citations:    
    131. Ethier SP, Chiodino C, Jones RF. Role of growth factor synthesis in the acquisition of insulin/insulin-like growth factor I independence in rat mammary carcinoma cells. Cancer Res. 1990 Sep 01; 50(17):5351-7. PMID: 1696849.
      Citations:    
    132. Ethier SP, Van de Velde RM. Secretion of a TGF-beta-like growth inhibitor by normal rat mammary epithelial cells in vitro. J Cell Physiol. 1990 Jan; 142(1):15-20. PMID: 2298817.
      Citations:    
    133. Ethier SP, van de Velde RM, Cundiff KC. cAMP levels in proliferating rat mammary epithelial cells in vitro and in vivo. Exp Cell Res. 1989 Jun; 182(2):653-8. PMID: 2542072.
      Citations:    
    134. Ethier SP, Cundiff KC. Importance of extended growth potential and growth factor independence on in vivo neoplastic potential of primary rat mammary carcinoma cells. Cancer Res. 1987 Oct 15; 47(20):5316-22. PMID: 3115564.
      Citations:    
    135. Adams LM, Ethier SP, Ullrich RL. Enhanced in vitro proliferation and in vivo tumorigenic potential of mammary epithelium from BALB/c mice exposed in vivo to gamma-radiation and/or 7,12-dimethylbenz[a]anthracene. Cancer Res. 1987 Aug 15; 47(16):4425-31. PMID: 3111686.
      Citations:    
    136. Ethier SP, Kudla A, Cundiff KC. Influence of hormone and growth factor interactions on the proliferative potential of normal rat mammary epithelial cells in vitro. J Cell Physiol. 1987 Jul; 132(1):161-7. PMID: 2439521.
      Citations:    
    137. Ethier SP. Serum-free culture conditions for the growth of normal rat mammary epithelial cells in primary culture. In Vitro Cell Dev Biol. 1986 Aug; 22(8):485-90. PMID: 3488312.
      Citations:    
    138. Ethier SP. Primary culture and serial passage of normal and carcinogen-treated rat mammary epithelial cells in vitro. J Natl Cancer Inst. 1985 Jun; 74(6):1307-18. PMID: 3889460.
      Citations:    
    139. Adams LM, Ethier SP, Ullrich RL. Survival of mammary epithelial cells from virgin female BALB/c mice following in vivo gamma irradiation. Radiat Res. 1984 Nov; 100(2):264-72. PMID: 6387778.
      Citations:    
    140. Ethier SP, Ullrich RL. Factors influencing expression of mammary ductal dysplasia in cell dissociation-derived murine mammary outgrowths. Cancer Res. 1984 Oct; 44(10):4523-7. PMID: 6432315.
      Citations:    
    141. Ethier SP, Adams LM, Ullrich RL. Morphological and histological characteristics of mammary dysplasias occurring in cell dissociation-derived murine mammary outgrowths. Cancer Res. 1984 Oct; 44(10):4517-22. PMID: 6205749.
      Citations:    
    142. Ethier SP, Ullrich RL. Detection of ductal dysplasia in mammary outgrowths derived from carcinogen-treated virgin female BALB/c mice. Cancer Res. 1982 May; 42(5):1753-60. PMID: 6802483.
      Citations:    
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