Jennifer L Mulligan

Title
InstitutionMedical University of South Carolina
DepartmentOtolaryngology - Head and Neck Surgery
AddressP.O. Box MSC 550
CRI 304G
135 Rutledge Ave.
Phone843-792-8286
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    Collapse Overview 
    Collapse keywords
    airway inflammation, Chronic sinusitis, Vitamin D, vitamin d deficiency, epithelial cells, vitamin d metabolism, fibroblast, nasal poly, immunology

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    R01AI134698     (MULLIGAN, JENNIFER KONOPA)Jun 15, 2018 - May 31, 2023
    NIH
    Role of Vitamin D Metabolism in CRS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mulligan JK, Patel K, Williamson T, Reaves N, Carroll W, Stephenson SE, Gao P, Drake RR, Neely BA, Tomlinson S, Schlosser RJ, Atkinson C. C3a receptor antagonism as a novel therapeutic target for chronic rhinosinusitis. Mucosal Immunol. 2018 09; 11(5):1375-1385. PMID: 29907871.
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    2. Taylor RJ, Schlosser RJ, Soler ZM, Mattos JL, Mulligan JK. Glucocorticoid receptor isoform expression in peripheral blood mononuclear leukocytes of patients with chronic rhinosinusitis. Int Forum Allergy Rhinol. 2018 May 02. PMID: 29719127.
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    3. Ganjaei KG, Soler ZM, Mappus ED, Taylor RJ, Worley ML, Mulligan JK, Mattos JL, Rowan NR, Garcia GJM, Dubno JR, Eckert MA, Matthews LJ, Schlosser RJ. Novel Radiographic Assessment of the Cribriform Plate. Am J Rhinol Allergy. 2018 May; 32(3):175-180. PMID: 29660990.
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    4. Palmer C, Mulligan JK, Smith SE, Atkinson C. The role of regulatory T cells in the regulation of upper airway inflammation. Am J Rhinol Allergy. 2017 Nov 01; 31(6):345-351. PMID: 29122078.
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    5. Smith SE, Schlosser RJ, Yawn JR, Mattos JL, Soler ZM, Mulligan JK. Sinonasal T-cell expression of cytotoxic mediators granzyme B and perforin is reduced in patients with chronic rhinosinusitis. Am J Rhinol Allergy. 2017 Nov 01; 31(6):352-356. PMID: 29122079.
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    6. Mulligan JK, Pasquini WN, Carroll WW, Williamson T, Reaves N, Patel KJ, Mappus E, Schlosser RJ, Atkinson C. Dietary vitamin D3 deficiency exacerbates sinonasal inflammation and alters local 25(OH)D3 metabolism. PLoS One. 2017; 12(10):e0186374. PMID: 29045457.
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    7. Sambandam Y, Reddy SV, Mulligan JL, Voelkel-Johnson C, Wagner CL. Vitamin D Modulation of TRAIL Expression in Human Milk and Mammary Epithelial Cells. Sci Rep. 2017 06 28; 7(1):4362. PMID: 28659589.
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    8. Mulligan JK, O'Connell BP, Pasquini W, Mulligan RM, Smith S, Soler ZM, Atkinson C, Schlosser RJ. Impact of tobacco smoke on upper airway dendritic cell accumulation and regulation by sinonasal epithelial cells. Int Forum Allergy Rhinol. 2017 08; 7(8):777-785. PMID: 28574651.
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    9. DiFranco KM, Mulligan JK, Sumal AS, Diamond G. Induction of CFTR gene expression by 1,25(OH)2 vitamin D3, 25OH vitamin D3, and vitamin D3 in cultured human airway epithelial cells and in mouse airways. J Steroid Biochem Mol Biol. 2017 10; 173:323-332. PMID: 28130182.
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    10. Schlosser RJ, Mulligan JK, Hyer JM, Karnezis TT, Gudis DA, Soler ZM. Mucous Cytokine Levels in Chronic Rhinosinusitis-Associated Olfactory Loss. JAMA Otolaryngol Head Neck Surg. 2016 08 01; 142(8):731-7. PMID: 27228459.
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    11. Carroll WW, Schlosser RJ, O'Connell BP, Soler ZM, Mulligan JK. Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2016 06; 6(6):605-10. PMID: 26750566.
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    12. Schlosser RJ, Carroll WW, Soler ZM, Pasquini WN, Mulligan JK. Reduced sinonasal levels of 1a-hydroxylase are associated with worse quality of life in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2016 Jan; 6(1):58-65. PMID: 26575398.
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    13. Carroll WW, O'Connell BP, Schlosser RJ, Gudis DA, Karnezis TT, Lawrence LA, Soler ZM, Mulligan JK. Fibroblast levels are increased in chronic rhinosinusitis with nasal polyps and are associated with worse subjective disease severity. Int Forum Allergy Rhinol. 2016 Feb; 6(2):162-8. PMID: 26370180.
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    14. Lawrence LA, Mulligan JK, Roach C, Pasquini WN, Soler ZM, Banglawala SM, Karnezis TT, Gudis DA, Schlosser RJ. Superoxide dismutase reduces the inflammatory response to Aspergillus and Alternaria in human sinonasal epithelial cells derived from patients with chronic rhinosinusitis. Am J Rhinol Allergy. 2015 Mar-Apr; 29(2):89-93. PMID: 25785747.
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    15. Yawn J, Lawrence LA, Carroll WW, Mulligan JK. Vitamin D for the treatment of respiratory diseases: is it the end or just the beginning? J Steroid Biochem Mol Biol. 2015 Apr; 148:326-37. PMID: 25625665.
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    16. Sansoni ER, Sautter NB, Mace JC, Smith TL, Yawn JR, Lawrence LA, Schlosser RJ, Soler ZM, Mulligan JK. Vitamin D3 as a novel regulator of basic fibroblast growth factor in chronic rhinosinusitis with nasal polyposis. Int Forum Allergy Rhinol. 2015 Mar; 5(3):191-6. PMID: 25561293.
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    17. Banglawala SM, Mulligan JK, Psaltis AJ, Wang EW, Nguyen SA, Mulligan RM, Crosby BL, Schlosser RJ. Impact of intraoperative hydrodebrider treatment on postoperative sinonasal inflammation. Am J Rhinol Allergy. 2014 Sep-Oct; 28(5):438-42. PMID: 25198033.
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    18. Wentzel JL, Mulligan JK, Soler ZM, White DR, Schlosser RJ. Passive smoke exposure in chronic rhinosinusitis as assessed by hair nicotine. Am J Rhinol Allergy. 2014 Jul-Aug; 28(4):297-301. PMID: 25197916.
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    19. Banks CA, Schlosser RJ, Wang EW, Casey SE, Mulligan RM, Mulligan JK. Macrophage Infiltrate Is Elevated in CRSwNP Sinonasal Tissue Regardless of Atopic Status. Otolaryngol Head Neck Surg. 2014 08; 151(2):215-20. PMID: 24705220.
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    20. Mulligan JK, Nagel W, O'Connell BP, Wentzel J, Atkinson C, Schlosser RJ. Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2014 Aug; 134(2):342-9. PMID: 24698317.
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    21. Schlosser RJ, Soler ZM, Schmedes GW, Storck K, Mulligan JK. Impact of vitamin D deficiency upon clinical presentation in nasal polyposis. Int Forum Allergy Rhinol. 2014 Mar; 4(3):196-9. PMID: 24415576.
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    22. O'Connell BP, Schlosser RJ, Wentzel JL, Nagel W, Mulligan JK. Systemic monocyte-derived dendritic cells and associated Th2 skewing in chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2014 Feb; 150(2):312-20. PMID: 24367054.
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    23. Oyer SL, Nagel W, Mulligan JK. Differential expression of adhesion molecules by sinonasal fibroblasts among control and chronic rhinosinusitis patients. Am J Rhinol Allergy. 2013 Sep-Oct; 27(5):381-6. PMID: 24119601.
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    24. Oyer SL, Mulligan JK, Psaltis AJ, Henriquez OA, Schlosser RJ. Cytokine correlation between sinus tissue and nasal secretions among chronic rhinosinusitis and controls. Laryngoscope. 2013 Dec; 123(12):E72-8. PMID: 23852962.
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    25. Fordham MT, Mulligan JK, Casey SE, Mulligan RM, Wang EW, Sansoni ER, Schlosser RJ. Reactive oxygen species in chronic rhinosinusitis and secondhand smoke exposure. Otolaryngol Head Neck Surg. 2013 Oct; 149(4):633-8. PMID: 23838308.
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    26. Psaltis AJ, Schlosser RJ, Yawn JR, Henriquez O, Mulligan JK. Characterization of B-cell subpopulations in patients with chronic rhinosinusitis. Int Forum Allergy Rhinol. 2013 Aug; 3(8):621-9. PMID: 23640795.
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    27. Mulligan JK, White DR, Wang EW, Sansoni SR, Moses H, Yawn RJ, Wagner C, Casey SE, Mulligan RM, Schlosser RJ. Vitamin D3 deficiency increases sinus mucosa dendritic cells in pediatric chronic rhinosinusitis with nasal polyps. Otolaryngol Head Neck Surg. 2012 Oct; 147(4):773-81. PMID: 22627120.
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    28. Mulligan JK, Mulligan RM, Atkinson C, Schlosser RJ. Human sinonasal epithelial cells direct dendritic function and T-cell T helper 1/T helper 2 skewing following Aspergillus exposure. Int Forum Allergy Rhinol. 2011 Jul-Aug; 1(4):268-74. PMID: 22287430.
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    29. Ayers CM, Schlosser RJ, O'Connell BP, Atkinson C, Mulligan RM, Casey SE, Bleier BS, Wang EW, Sansoni ER, Kuhlen JL, Mulligan JK. Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Int Forum Allergy Rhinol. 2011 Jul-Aug; 1(4):296-302. PMID: 22287435.
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    30. Mulligan JK, Bleier BS, O'Connell B, Mulligan RM, Wagner C, Schlosser RJ. Vitamin D3 correlates inversely with systemic dendritic cell numbers and bone erosion in chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Clin Exp Immunol. 2011 Jun; 164(3):312-20. PMID: 21401575.
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    31. Davis KS, Casey SE, Mulligan JK, Mulligan RM, Schlosser RJ, Atkinson C. Murine complement deficiency ameliorates acute cigarette smoke-induced nasal damage. Otolaryngol Head Neck Surg. 2010 Jul; 143(1):152-8. PMID: 20620635.
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    32. Mulligan JK, Young MR. Tumors induce the formation of suppressor endothelial cells in vivo. Cancer Immunol Immunother. 2010 Feb; 59(2):267-77. PMID: 19669642.
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    33. Mulligan JK, Rosenzweig SA, Young MR. Tumor secretion of VEGF induces endothelial cells to suppress T cell functions through the production of PGE2. J Immunother. 2010 Feb-Mar; 33(2):126-35. PMID: 20145550.
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    34. Mulligan JK, Day TA, Gillespie MB, Rosenzweig SA, Young MR. Secretion of vascular endothelial growth factor by oral squamous cell carcinoma cells skews endothelial cells to suppress T-cell functions. Hum Immunol. 2009 Jun; 70(6):375-82. PMID: 19480853.
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    35. Mulligan JK, Lathers DM, Young MR. Tumors skew endothelial cells to disrupt NK cell, T-cell and macrophage functions. Cancer Immunol Immunother. 2008 Jul; 57(7):951-61. PMID: 18058097.
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    36. Laber K, Veatch LM, Lopez MF, Mulligan JK, Lathers DM. Effects of housing density on weight gain, immune function, behavior, and plasma corticosterone concentrations in BALB/c and C57BL/6 mice. J Am Assoc Lab Anim Sci. 2008 Mar; 47(2):16-23. PMID: 18351717.
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    37. Wang Y, Meng A, Lang H, Brown SA, Konopa JL, Kindy MS, Schmiedt RA, Thompson JS, Zhou D. Activation of nuclear factor kappaB In vivo selectively protects the murine small intestine against ionizing radiation-induced damage. Cancer Res. 2004 Sep 01; 64(17):6240-6. PMID: 15342410.
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    38. Brown S, Konopa J, Zhou D, Thompson J. Expression of TNFalpha by CD3+ and F4/80+ cells following irradiation preconditioning and allogeneic spleen cell transplantation. Bone Marrow Transplant. 2004 Feb; 33(4):359-65. PMID: 14676780.
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