Last Name

Hongjun Wang

InstitutionMedical University of South Carolina
DepartmentGI Surgery
AddressP.O. Box MSC 613
BSB 641
173 Ashley Ave.
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    Islet cell transplantation is the most potent therapy for patients with type 1 diabetes. However, there are two major problems besetting this process. First, there are not enough islets available for transplant. Second, islets after transplantation are often undergoing apoptosis due to the stresses encountered during islet harvest and after transplantation. The ongoing projects in the Islet Cell Transplantation lab led by Dr. Hongjun Wang are focused on solving these problems.

    The areas of investigation in the Wang lab include:

    Generation of insulin-secreting cells from adipose stem cells to expand the source of transplanted islets
    Mechanisms that lead to islet death after allogeneic and autologous islet transplantation
    Interventional approaches that can protect islets from apoptosis and immune rejection by induction of protective genes or encapsulating islets with nanoparticles
    the role of HO-1 in obesity and insulin resistance
    a translational approach that can prevent the onset of surgical diabetes after total pancreatectomy and islet autotransplantation for patients with chronic pancreatitis.
    Collapse keywords
    Insulin, Inflammation, Diabetes

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Feng X, Juan AH, Wang HA, Ko KD, Zare H, Sartorelli V. Polycomb Ezh2 controls the fate of GABAergic neurons in the embryonic cerebellum. Development. 2016 06 01; 143(11):1971-80. PMID: 27068104.
      View in: PubMed
    2. Wang H, Wu H, Rocuts F, Gu Z, Bach FH, Otterbein LE. Activation of peroxisome proliferator-activated receptor ? prolongs islet allograft survival. Cell Transplant. 2012; 21(10):2111-8. PMID: 22469179.
      View in: PubMed
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