Kenneth D. Tew

TitleChair, Department of Cell and Molecular Pharmacology and Experimental Therapeutics
InstitutionMedical University of South Carolina
DepartmentCell and Molecular Pharmacology and Experimental Therapeutics
AddressP.O. Box MSC 509
BSB 358
Basic Science Building - 173 Ashley Ave.
Phone843-792-2514
Fax843-792-2475
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    Men-s Health, Cancer/Other, Cancer

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Qin S, He X, Lin H, Schulte BA, Zhao M, Tew KD, Wang GY. Nrf2 inhibition sensitizes breast cancer stem cells to ionizing radiation via suppressing DNA repair. Free Radic Biol Med. 2021 Jun; 169:238-247. PMID: 33892113.
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    2. Zhang L, Kim SH, Park KH, Zhi-Wei Y, Jie Z, Townsend DM, Tew KD. Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish. J Pharmacol Exp Ther. 2021 04; 377(1):121-132. PMID: 33514607.
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    3. Zhang J, Ye ZW, Janssen-Heininger Y, Townsend DM, Tew KD. Development of Telintra as an Inhibitor of Glutathione S-Transferase P. Handb Exp Pharmacol. 2021; 264:71-91. PMID: 32767141.
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    4. Zhang J, Ye ZW, Chen W, Culpepper J, Jiang H, Ball LE, Mehrotra S, Blumental-Perry A, Tew KD, Townsend DM. Altered redox regulation and S-glutathionylation of BiP contribute to bortezomib resistance in multiple myeloma. Free Radic Biol Med. 2020 11 20; 160:755-767. PMID: 32937189.
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    5. Hayes JD, Dinkova-Kostova AT, Tew KD. Oxidative Stress in Cancer. Cancer Cell. 2020 08 10; 38(2):167-197. PMID: 32649885.
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    6. Zhang L, Townsend DM, Morris M, Maldonado EN, Jiang YL, Broome AM, Bethard JR, Ball LE, Tew KD. Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone. J Pharmacol Exp Ther. 2020 08; 374(2):308-318. PMID: 32546528.
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    7. Bartolini D, Tew KD, Marinelli R, Galli F, Wang GY. Nrf2-modulation by seleno-hormetic agents and its potential for radiation protection. Biofactors. 2020 Mar; 46(2):239-245. PMID: 31617634.
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    8. Zhang L, Zhang J, Ye Z, Manevich Y, Townsend DM, Marshall DT, Tew KD. S-Glutathionylated Serine Proteinase Inhibitors as Biomarkers for Radiation Exposure in Prostate Cancer Patients. Sci Rep. 2019 09 24; 9(1):13792. PMID: 31551460.
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    9. Zhang L, Zhang J, Ye Z, Manevich Y, Ball LE, Bethard JR, Jiang YL, Broome AM, Dalton AC, Wang GY, Townsend DM, Tew KD. Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1. Cancer Res. 2019 08 15; 79(16):4072-4085. PMID: 31227482.
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    10. Zhong G, Qin S, Townsend D, Schulte BA, Tew KD, Wang GY. Oxidative stress induces senescence in breast cancer stem cells. Biochem Biophys Res Commun. 2019 07 05; 514(4):1204-1209. PMID: 31109646.
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    11. Bartolini D, Wang Y, Zhang J, Giustarini D, Rossi R, Wang GY, Torquato P, Townsend DM, Tew KD, Galli F. A seleno-hormetine protects bone marrow hematopoietic cells against ionizing radiation-induced toxicities. PLoS One. 2019; 14(4):e0205626. PMID: 31034521.
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    12. Zhang J, Ye ZW, Townsend DM, Hughes-Halbert C, Tew KD. Racial disparities, cancer and response to oxidative stress. Adv Cancer Res. 2019; 144:343-383. PMID: 31349903.
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    13. Zhang L, Zhang J, Ye Z, Townsend DM, Tew KD. Pharmacology of ME-344, a novel cytotoxic isoflavone. Adv Cancer Res. 2019; 142:187-207. PMID: 30885362.
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    14. Bräutigam L, Zhang J, Dreij K, Spahiu L, Holmgren A, Abe H, Tew KD, Townsend DM, Kelner MJ, Morgenstern R, Johansson K. MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation. Redox Biol. 2018 07; 17:171-179. PMID: 29702404.
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    15. Zhang J, Ye ZW, Singh S, Townsend DM, Tew KD. An evolving understanding of the S-glutathionylation cycle in pathways of redox regulation. Free Radic Biol Med. 2018 05 20; 120:204-216. PMID: 29578070.
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    16. Zhang J, Ye ZW, Chen W, Manevich Y, Mehrotra S, Ball L, Janssen-Heininger Y, Tew KD, Townsend DM. S-Glutathionylation of estrogen receptor a affects dendritic cell function. J Biol Chem. 2018 03 23; 293(12):4366-4380. PMID: 29374060.
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    17. Davis W, Tew KD. ATP-binding cassette transporter-2 (ABCA2) as a therapeutic target. Biochem Pharmacol. 2018 05; 151:188-200. PMID: 29223352.
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    18. Bartolini D, Sancineto L, Fabro de Bem A, Tew KD, Santi C, Radi R, Toquato P, Galli F. Selenocompounds in Cancer Therapy: An Overview. Adv Cancer Res. 2017; 136:259-302. PMID: 29054421.
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    19. Yang A, Qin S, Schulte BA, Ethier SP, Tew KD, Wang GY. MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer. Cancer Res. 2017 12 01; 77(23):6641-6650. PMID: 28951456.
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    20. Tew KD, Galli F. Preface. Adv Cancer Res. 2017; 136:xi-xiv. PMID: 29054424.
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    21. Tew KD. Commentary on "Proteasome Inhibitors: A Novel Class of Potent and Effective Antitumor Agents". Cancer Res. 2016 09 01; 76(17):4916-7. PMID: 27587650.
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    22. McMillan DH, van der Velden JL, Lahue KG, Qian X, Schneider RW, Iberg MS, Nolin JD, Abdalla S, Casey DT, Tew KD, Townsend DM, Henderson CJ, Wolf CR, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, van der Vliet A, Flemer S, Anathy V, Janssen-Heininger YM. Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase p. JCI Insight. 2016 Jun 02; 1(8). PMID: 27358914.
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    23. Manevich Y, Reyes L, Britten CD, Townsend DM, Tew KD. Redox Signaling and Bioenergetics Influence Lung Cancer Cell Line Sensitivity to the Isoflavone ME-344. J Pharmacol Exp Ther. 2016 08; 358(2):199-208. PMID: 27255112.
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    24. van Gisbergen MW, Cebula M, Zhang J, Ottosson-Wadlund A, Dubois L, Lambin P, Tew KD, Townsend DM, Haenen GR, Drittij-Reijnders MJ, Saneyoshi H, Araki M, Shishido Y, Ito Y, Arnér ES, Abe H, Morgenstern R, Johansson K. Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells. Mol Pharm. 2016 06 06; 13(6):2010-25. PMID: 27093577.
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    25. Jones JT, Qian X, van der Velden JL, Chia SB, McMillan DH, Flemer S, Hoffman SM, Lahue KG, Schneider RW, Nolin JD, Anathy V, van der Vliet A, Townsend DM, Tew KD, Janssen-Heininger YM. Glutathione S-transferase pi modulates NF-?B activation and pro-inflammatory responses in lung epithelial cells. Redox Biol. 2016 08; 8:375-82. PMID: 27058114.
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    26. Ye ZW, Zhang J, Ancrum T, Manevich Y, Townsend DM, Tew KD. Glutathione S-Transferase P-Mediated Protein S-Glutathionylation of Resident Endoplasmic Reticulum Proteins Influences Sensitivity to Drug-Induced Unfolded Protein Response. Antioxid Redox Signal. 2017 02 20; 26(6):247-261. PMID: 26838680.
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    27. Kenche H, Ye ZW, Vedagiri K, Richards DM, Gao XH, Tew KD, Townsend DM, Blumental-Perry A. Adverse Outcomes Associated with Cigarette Smoke Radicals Related to Damage to Protein-disulfide Isomerase. J Biol Chem. 2016 Feb 26; 291(9):4763-78. PMID: 26728460.
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    28. Tew KD. Glutathione-Associated Enzymes In Anticancer Drug Resistance. Cancer Res. 2016 Jan 01; 76(1):7-9. PMID: 26729789.
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    29. Tew KD. Editor's Note. J Pharmacol Exp Ther. 2016 Jan; 356(1):1. PMID: 26628499.
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    30. Ye ZW, Zhang J, Townsend DM, Tew KD. Oxidative stress, redox regulation and diseases of cellular differentiation. Biochim Biophys Acta. 2015 Aug; 1850(8):1607-21. PMID: 25445706.
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    31. Bartolini D, Piroddi M, Tidei C, Giovagnoli S, Pietrella D, Manevich Y, Tew KD, Giustarini D, Rossi R, Townsend DM, Santi C, Galli F. Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its D,L-polylactide microparticle formulation. Free Radic Biol Med. 2015 Jan; 78:56-65. PMID: 25452145.
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    32. Zhang J, Ye ZW, Gao P, Reyes L, Jones EE, Branham-O'Connor M, Blumer JB, Drake RR, Manevich Y, Townsend DM, Tew KD. Glutathione S-transferase P influences redox and migration pathways in bone marrow. PLoS One. 2014; 9(9):e107478. PMID: 25216273.
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    33. Grek CL, Reyes L, Townsend DM, Tew KD. S-glutathionylation of buccal cell proteins as biomarkers of exposure to hydrogen peroxide. BBA Clin. 2014 Dec; 2:31-9. PMID: 26673080.
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    34. Manevich Y, Hutchens S, Halushka PV, Tew KD, Townsend DM, Jauch EC, Borg K. Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome. Free Radic Biol Med. 2014 Jul; 72:210-21. PMID: 24726861.
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    35. Zhang J, Grek C, Ye ZW, Manevich Y, Tew KD, Townsend DM. Pleiotropic functions of glutathione S-transferase P. Adv Cancer Res. 2014; 122:143-75. PMID: 24974181.
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    36. Grek CL, Zhang J, Manevich Y, Townsend DM, Tew KD. Causes and consequences of cysteine S-glutathionylation. J Biol Chem. 2013 Sep 13; 288(37):26497-504. PMID: 23861399.
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    37. Manevich Y, Hutchens S, Tew KD, Townsend DM. Allelic variants of glutathione S-transferase P1-1 differentially mediate the peroxidase function of peroxiredoxin VI and alter membrane lipid peroxidation. Free Radic Biol Med. 2013 Jan; 54:62-70. PMID: 23142420.
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    38. Bowers RR, Manevich Y, Townsend DM, Tew KD. Sulfiredoxin redox-sensitive interaction with S100A4 and non-muscle myosin IIA regulates cancer cell motility. Biochemistry. 2012 Oct 02; 51(39):7740-54. PMID: 22934964.
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    39. Anathy V, Roberson E, Cunniff B, Nolin JD, Hoffman S, Spiess P, Guala AS, Lahue KG, Goldman D, Flemer S, van der Vliet A, Heintz NH, Budd RC, Tew KD, Janssen-Heininger YM. Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis. Mol Cell Biol. 2012 Sep; 32(17):3464-78. PMID: 22751926.
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    40. Mack JT, Brown CB, Garrett TE, Uys JD, Townsend DM, Tew KD. Ablation of the ATP-binding cassette transporter, Abca2 modifies response to estrogen-based therapies. Biomed Pharmacother. 2012 Sep; 66(6):403-8. PMID: 22898081.
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    41. Tew KD, Townsend DM. Glutathione-s-transferases as determinants of cell survival and death. Antioxid Redox Signal. 2012 Dec 15; 17(12):1728-37. PMID: 22540427.
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    42. Calpe-Berdiel L, Zhao Y, de Graauw M, Ye D, van Santbrink PJ, Mommaas AM, Foks A, Bot M, Meurs I, Kuiper J, Mack JT, Van Eck M, Tew KD, van Berkel TJ. Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice. Atherosclerosis. 2012 Aug; 223(2):332-41. PMID: 22748276.
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    43. Xiong Y, Manevich Y, Tew KD, Townsend DM. S-Glutathionylation of Protein Disulfide Isomerase Regulates Estrogen Receptor a Stability and Function. Int J Cell Biol. 2012; 2012:273549. PMID: 22654912.
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    44. Grünewald E, Tew KD, Porteous DJ, Thomson PA. Developmental expression of orphan G protein-coupled receptor 50 in the mouse brain. ACS Chem Neurosci. 2012 Jun 20; 3(6):459-72. PMID: 22860215.
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    45. Grek CL, Townsend DM, Uys JD, Manevich Y, Coker WJ, Pazoles CJ, Tew KD. S-glutathionylated serine proteinase inhibitors as plasma biomarkers in assessing response to redox-modulating drugs. Cancer Res. 2012 May 01; 72(9):2383-93. PMID: 22406622.
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    46. Tew KD. NrF2 /Keap1 as gatekeepers of redox homeostasis – do they prevent or cause cancer? Pigment Cell Melanoma Res. 2011 Dec; 24(6):1078-9. PMID: 22216435.
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    47. Tew KD. Drug resistance in cancer. Editorial. Biochem Pharmacol. 2012 Apr 15; 83(8):985-6. PMID: 22155295.
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    48. Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-ß production by altering Nicastrin maturation and intracellular localization. J Biol Chem. 2012 Jan 06; 287(2):1100-11. PMID: 22086926.
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    49. Uys JD, Knackstedt L, Hurt P, Tew KD, Manevich Y, Hutchens S, Townsend DM, Kalivas PW. Cocaine-induced adaptations in cellular redox balance contributes to enduring behavioral plasticity. Neuropsychopharmacology. 2011 Nov; 36(12):2551-60. PMID: 21796101.
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    50. Xiong Y, Uys JD, Tew KD, Townsend DM. S-glutathionylation: from molecular mechanisms to health outcomes. Antioxid Redox Signal. 2011 Jul 01; 15(1):233-70. PMID: 21235352.
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    51. Tew KD, Manevich Y, Grek C, Xiong Y, Uys J, Townsend DM. The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer. Free Radic Biol Med. 2011 Jul 15; 51(2):299-313. PMID: 21558000.
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    52. Tew KD, Townsend DM. Regulatory functions of glutathione S-transferase P1-1 unrelated to detoxification. Drug Metab Rev. 2011 May; 43(2):179-93. PMID: 21351850.
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    53. Manevich Y, Townsend DM, Hutchens S, Tew KD. Diazeniumdiolate mediated nitrosative stress alters nitric oxide homeostasis through intracellular calcium and S-glutathionylation of nitric oxide synthetase. PLoS One. 2010 Nov 30; 5(11):e14151. PMID: 21152397.
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    54. Tew KD, Townsend DM. Redox platforms in cancer drug discovery and development. Curr Opin Chem Biol. 2011 Feb; 15(1):156-61. PMID: 21075043.
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    55. Mack JT, Helke KL, Normand G, Green C, Townsend DM, Tew KD. ABCA2 transporter deficiency reduces incidence of TRAMP prostate tumor metastasis and cellular chemotactic migration. Cancer Lett. 2011 Jan 28; 300(2):154-61. PMID: 21041019.
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    56. Grek CL, Townsend DM, Tew KD. The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies. Pharmacol Ther. 2011 Feb; 129(2):172-84. PMID: 20951732.
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    57. Grek CL, Tew KD. Redox metabolism and malignancy. Curr Opin Pharmacol. 2010 Aug; 10(4):362-8. PMID: 20627682.
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    58. Hutchens S, Manevich Y, He L, Tew KD, Townsend DM. Cellular resistance to a nitric oxide releasing glutathione S-transferase P-activated prodrug, PABA/NO. Invest New Drugs. 2011 Oct; 29(5):719-29. PMID: 20232108.
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    59. Uys JD, Manevich Y, Devane LC, He L, Garret TE, Pazoles CJ, Tew KD, Townsend DM. Preclinical pharmacokinetic analysis of NOV-002, a glutathione disulfide mimetic. Biomed Pharmacother. 2010 Sep; 64(7):493-8. PMID: 20359856.
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    60. Jenderny S, Lin H, Garrett T, Tew KD, Townsend DM. Protective effects of a glutathione disulfide mimetic (NOV-002) against cisplatin induced kidney toxicity. Biomed Pharmacother. 2010 Jan; 64(1):73-6. PMID: 19896793.
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    61. Townsend DM, Manevich Y, He L, Xiong Y, Bowers RR, Hutchens S, Tew KD. Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response. Cancer Res. 2009 Oct 01; 69(19):7626-34. PMID: 19773442.
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    62. Townsend DM, Manevich Y, He L, Hutchens S, Pazoles CJ, Tew KD. Novel role for glutathione S-transferase pi. Regulator of protein S-Glutathionylation following oxidative and nitrosative stress. J Biol Chem. 2009 Jan 02; 284(1):436-445. PMID: 18990698.
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    63. Townsend DM, Tew KD. Pharmacology of a mimetic of glutathione disulfide, NOV-002. Biomed Pharmacother. 2009 Feb; 63(2):75-8. PMID: 18851905.
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    64. Townsend DM, Tew KD, He L, King JB, Hanigan MH. Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity. Biomed Pharmacother. 2009 Feb; 63(2):79-85. PMID: 18819770.
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    65. Townsend DM, Pazoles CJ, Tew KD. NOV-002, a mimetic of glutathione disulfide. Expert Opin Investig Drugs. 2008 Jul; 17(7):1075-83. PMID: 18549343.
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    66. Lei K, Townsend DM, Tew KD. Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response. Oncogene. 2008 Aug 21; 27(36):4877-87. PMID: 18454177.
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    67. Townsend DM, He L, Hutchens S, Garrett TE, Pazoles CJ, Tew KD. NOV-002, a glutathione disulfide mimetic, as a modulator of cellular redox balance. Cancer Res. 2008 Apr 15; 68(8):2870-7. PMID: 18413755.
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    68. Mack JT, Brown CB, Tew KD. ABCA2 as a therapeutic target in cancer and nervous system disorders. Expert Opin Ther Targets. 2008 Apr; 12(4):491-504. PMID: 18348684.
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    69. Tew KD. Redox pathways in cancer drug discovery. Curr Opin Pharmacol. 2007 Aug; 7(4):353-354. PMID: 19823694.
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    70. Mack JT, Townsend DM, Beljanski V, Tew KD. The ABCA2 transporter: intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds. Curr Drug Metab. 2007 Jan; 8(1):47-57. PMID: 17266523.
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    71. Mack JT, Beljanski V, Soulika AM, Townsend DM, Brown CB, Davis W, Tew KD. "Skittish" Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system. Mol Cell Biol. 2007 Jan; 27(1):44-53. PMID: 17060448.
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    72. Tew KD. Redox in redux: Emergent roles for glutathione S-transferase P (GSTP) in regulation of cell signaling and S-glutathionylation. Biochem Pharmacol. 2007 May 01; 73(9):1257-69. PMID: 17098212.
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    73. Mack JT, Beljanski V, Tew KD, Townsend DM. The ATP-binding cassette transporter ABCA2 as a mediator of intracellular trafficking. Biomed Pharmacother. 2006 Nov; 60(9):587-92. PMID: 17029687.
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    74. Tew KD. How is a conservative US administration influencing NCI funding? Biomed Pharmacother. 2006 Nov; 60(9):500-1. PMID: 17045450.
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    75. Findlay VJ, Townsend DM, Morris TE, Fraser JP, He L, Tew KD. A novel role for human sulfiredoxin in the reversal of glutathionylation. Cancer Res. 2006 Jul 01; 66(13):6800-6. PMID: 16818657.
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    76. McIlwain CC, Townsend DM, Tew KD. Glutathione S-transferase polymorphisms: cancer incidence and therapy. Oncogene. 2006 Mar 13; 25(11):1639-48. PMID: 16550164.
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    77. Saavedra JE, Srinivasan A, Buzard GS, Davies KM, Waterhouse DJ, Inami K, Wilde TC, Citro ML, Cuellar M, Deschamps JR, Parrish D, Shami PJ, Findlay VJ, Townsend DM, Tew KD, Singh S, Jia L, Ji X, Keefer LK. PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity. J Med Chem. 2006 Feb 09; 49(3):1157-64. PMID: 16451080.
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    78. Townsend DM, Findlay VJ, Fazilev F, Ogle M, Fraser J, Saavedra JE, Ji X, Keefer LK, Tew KD. A glutathione S-transferase pi-activated prodrug causes kinase activation concurrent with S-glutathionylation of proteins. Mol Pharmacol. 2006 Feb; 69(2):501-8. PMID: 16288082.
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    79. Tucker JM, Lipatova Z, Beljanski V, Townsend DM, Tew KD. Evaluation of lipophilins as determinants of tumor cell response to estramustine. J Pharmacol Exp Ther. 2005 Dec; 315(3):1158-62. PMID: 16120813.
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    80. Tew KD. TLK-286: a novel glutathione S-transferase-activated prodrug. Expert Opin Investig Drugs. 2005 Aug; 14(8):1047-54. PMID: 16050796.
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    81. Beljanski V, Soulika A, Tucker JM, Townsend DM, Davis W, Tew KD. Characterization of the ATPase activity of human ATP-binding cassette transporter-2 (ABCA2). In Vivo. 2005 Jul-Aug; 19(4):657-60. PMID: 15999530.
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    82. Townsend DM, Findlay VL, Tew KD. Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets. Methods Enzymol. 2005; 401:287-307. PMID: 16399394.
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    83. Gate L, Majumdar RS, Lunk A, Tew KD. Influence of glutathione S-transferase pi and p53 expression on tumor frequency and spectrum in mice. Int J Cancer. 2005 Jan 01; 113(1):29-35. PMID: 15386426.
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    84. Tew KD, Boyd JT, Chen ZJ, Davis W, Fazilev F, Findlay V, Gaté L, Ile K, Soulika A, Townsend DM. Glutathione and ABC transporters as determinants of sensitivity to oxidative and nitrosative stress. J Nutr. 2004 Nov; 134(11):3205S-3206S. PMID: 15514308.
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    85. Davis W, Boyd JT, Ile KE, Tew KD. Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells. Biochim Biophys Acta. 2004 Jul 05; 1683(1-3):89-100. PMID: 15238223.
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    86. Boonstra R, Timmer-Bosscha H, van Echten-Arends J, van der Kolk DM, van den Berg A, de Jong B, Tew KD, Poppema S, de Vries EG. Mitoxantrone resistance in a small cell lung cancer cell line is associated with ABCA2 upregulation. Br J Cancer. 2004 Jun 14; 90(12):2411-7. PMID: 15150577.
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    87. Chen ZJ, Vulevic B, Ile KE, Soulika A, Davis W, Reiner PB, Connop BP, Nathwani P, Trojanowski JQ, Tew KD. Association of ABCA2 expression with determinants of Alzheimer's disease. FASEB J. 2004 Jul; 18(10):1129-31. PMID: 15155565.
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    88. Findlay VJ, Townsend DM, Saavedra JE, Buzard GS, Citro ML, Keefer LK, Ji X, Tew KD. Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug. Mol Pharmacol. 2004 May; 65(5):1070-9. PMID: 15102935.
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    89. Ile KE, Davis W, Boyd JT, Soulika AM, Tew KD. Identification of a novel first exon of the human ABCA2 transporter gene encoding a unique N-terminus. Biochim Biophys Acta. 2004 Apr 16; 1678(1):22-32. PMID: 15093135.
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    90. Tapiero H, Townsend DM, Tew KD. Organosulfur compounds from alliaceae in the prevention of human pathologies. Biomed Pharmacother. 2004 Apr; 58(3):183-93. PMID: 15164729.
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    91. Tew KD. Small molecule inhibition of hypoxia inducible factor-1alpha: a viable therapeutic approach? . 2004 Mar; 3(3):245-6. PMID: 15026544.
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    92. Tapiero H, Townsend DM, Tew KD. The role of carotenoids in the prevention of human pathologies. Biomed Pharmacother. 2004 Mar; 58(2):100-10. PMID: 14992791.
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    93. Townsend DM, Tew KD, Tapiero H. Sulfur containing amino acids and human disease. Biomed Pharmacother. 2004 Jan; 58(1):47-55. PMID: 14739061.
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    94. Chen ZJ, Tew KD. Amplified differential gene expression microarray. Methods Mol Biol. 2004; 258:95-106. PMID: 14970459.
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    95. Gate L, Majumdar RS, Lunk A, Tew KD. Increased myeloproliferation in glutathione S-transferase pi-deficient mice is associated with a deregulation of JNK and Janus kinase/STAT pathways. J Biol Chem. 2004 Mar 05; 279(10):8608-16. PMID: 14684749.
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    96. Tapiero H, Tew KD. Trace elements in human physiology and pathology: zinc and metallothioneins. Biomed Pharmacother. 2003 Nov; 57(9):399-411. PMID: 14652165.
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    97. Tapiero H, Townsend DM, Tew KD. Trace elements in human physiology and pathology. Copper. Biomed Pharmacother. 2003 Nov; 57(9):386-98. PMID: 14652164.
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    98. Townsend DM, Tew KD. The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene. 2003 Oct 20; 22(47):7369-75. PMID: 14576844.
      Citations:    
    99. Tapiero H, Townsend DM, Tew KD. Phytosterols in the prevention of human pathologies. Biomed Pharmacother. 2003 Oct; 57(8):321-5. PMID: 14568225.
      Citations:    
    100. Efferth T, Sauerbrey A, Olbrich A, Gebhart E, Rauch P, Weber HO, Hengstler JG, Halatsch ME, Volm M, Tew KD, Ross DD, Funk JO. Molecular modes of action of artesunate in tumor cell lines. Mol Pharmacol. 2003 Aug; 64(2):382-94. PMID: 12869643.
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    101. Chen ZJ, Gaté L, Davis W, Ile KE, Tew KD. Sensitivity and fidelity of DNA microarray improved with integration of Amplified Differential Gene Expression (ADGE). BMC Genomics. 2003 Jul 14; 4(1):28. PMID: 12859795.
      Citations:    
    102. Gaté L, Lunk A, Tew KD. Resistance to phorbol 12-myristate 13-acetate-induced cell growth arrest in an HL60 cell line chronically exposed to a glutathione S-transferase pi inhibitor. Biochem Pharmacol. 2003 May 15; 65(10):1611-22. PMID: 12754097.
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    103. Townsend DM, Tew KD, Tapiero H. The importance of glutathione in human disease. Biomed Pharmacother. 2003 May-Jun; 57(3-4):145-55. PMID: 12818476.
      Citations:    
    104. Tapiero H, Townsend DM, Tew KD. The antioxidant role of selenium and seleno-compounds. Biomed Pharmacother. 2003 May-Jun; 57(3-4):134-44. PMID: 12818475.
      Citations:    
    105. Davis W, Chen ZJ, Ile KE, Tew KD. Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors. Nucleic Acids Res. 2003 Feb 01; 31(3):1097-107. PMID: 12560508.
      Citations:    
    106. Townsend D, Tew K. Cancer drugs, genetic variation and the glutathione-S-transferase gene family. Am J Pharmacogenomics. 2003; 3(3):157-72. PMID: 12814324.
      Citations:    
    107. Chen ZJ, Gaté L, Davis W, Ile KE, Tew KD. Integration of amplified differential gene expression (ADGE) and DNA microarray. IUBMB Life. 2002 Dec; 54(6):335-8. PMID: 12665243.
      Citations:    
    108. Tapiero H, Mathé G, Couvreur P, Tew KD. I. Arginine. Biomed Pharmacother. 2002 Nov; 56(9):439-45. PMID: 12481980.
      Citations:    
    109. Tapiero H, Mathé G, Couvreur P, Tew KD. II. Glutamine and glutamate. Biomed Pharmacother. 2002 Nov; 56(9):446-57. PMID: 12481981.
      Citations:    
    110. Townsend DM, Shen H, Staros AL, Gaté L, Tew KD. Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer cells. . 2002 Oct; 1(12):1089-95. PMID: 12481432.
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    111. Tapiero H, Ba GN, Couvreur P, Tew KD. Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies. Biomed Pharmacother. 2002 Jul; 56(5):215-22. PMID: 12199620.
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    112. Tapiero H, Tew KD, Ba GN, Mathé G. Polyphenols: do they play a role in the prevention of human pathologies? Biomed Pharmacother. 2002 Jun; 56(4):200-7. PMID: 12109813.
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    113. Golemis EA, Tew KD, Dadke D. Protein interaction-targeted drug discovery: evaluating critical issues. Biotechniques. 2002 Mar; 32(3):636-8, 640, 642 passim. PMID: 11911666.
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    114. Tapiero H, Ba GN, Tew KD. Estrogens and environmental estrogens. Biomed Pharmacother. 2002 Feb; 56(1):36-44. PMID: 11905507.
      Citations:    
    115. Tapiero H, Tew KD, Gaté L, Machover D. Prevention of pathologies associated with oxidative stress and dietary intake deficiencies: folate deficiency and requirements. Biomed Pharmacother. 2001 Sep; 55(7):381-90. PMID: 11669501.
      Citations:    
    116. Gaté L, Tew KD. Glutathione S-transferases as emerging therapeutic targets. Expert Opin Ther Targets. 2001 Aug; 5(4):477-489. PMID: 12540261.
      Citations:    
    117. Ruscoe JE, Rosario LA, Wang T, Gaté L, Arifoglu P, Wolf CR, Henderson CJ, Ronai Z, Tew KD. Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways. J Pharmacol Exp Ther. 2001 Jul; 298(1):339-45. PMID: 11408560.
      Citations:    
    118. Tapiero H, Gaté L, Tew KD. Iron: deficiencies and requirements. Biomed Pharmacother. 2001 Jul; 55(6):324-32. PMID: 11478585.
      Citations:    
    119. Shen H, Chen ZJ, Zilfou JT, Hopper E, Murphy M, Tew KD. Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs. J Pharmacol Exp Ther. 2001 Jun; 297(3):1067-73. PMID: 11356930.
      Citations:    
    120. Chen ZJ, Shen H, Tew KD. Gene expression profiling using a novel method: amplified differential gene expression (ADGE). Nucleic Acids Res. 2001 May 15; 29(10):E46. PMID: 11353091.
      Citations:    
    121. Vulevic B, Chen Z, Boyd JT, Davis W, Walsh ES, Belinsky MG, Tew KD. Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2). Cancer Res. 2001 Apr 15; 61(8):3339-47. PMID: 11309290.
      Citations:    
    122. Wang T, Arifoglu P, Ronai Z, Tew KD. Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus. J Biol Chem. 2001 Jun 15; 276(24):20999-1003. PMID: 11279197.
      Citations:    
    123. Davis W, Ronai Z, Tew KD. Cellular thiols and reactive oxygen species in drug-induced apoptosis. J Pharmacol Exp Ther. 2001 Jan; 296(1):1-6. PMID: 11123355.
      Citations:    
    124. Tew KD. Is there a role for glyoxalase I inhibitors as antitumor drugs? Drug Resist Updat. 2000 Oct; 3(5):263-264. PMID: 11498393.
      Citations:    
    125. O'Brien M, Kruh GD, Tew KD. The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance. J Pharmacol Exp Ther. 2000 Aug; 294(2):480-7. PMID: 10900222.
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    126. Yin Z, Ivanov VN, Habelhah H, Tew K, Ronai Z. Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases. Cancer Res. 2000 Aug 01; 60(15):4053-7. PMID: 10945608.
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    127. Rosario LA, O'Brien ML, Henderson CJ, Wolf CR, Tew KD. Cellular response to a glutathione S-transferase P1-1 activated prodrug. Mol Pharmacol. 2000 Jul; 58(1):167-74. PMID: 10860939.
      Citations:    
    128. Frei E, Ara G, Teicher B, Bunnell C, Richardson P, Wheeler C, Tew K, Elias A. Double high-dose chemotherapy with stem cell rescue (HD-SCR) in patients with breast cancer - effect of sequence. Cancer Chemother Pharmacol. 2000; 45(3):239-46. PMID: 10663642.
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    129. O'Brien ML, Vulevic B, Freer S, Boyd J, Shen H, Tew KD. Glutathione peptidomimetic drug modulator of multidrug resistance-associated protein. J Pharmacol Exp Ther. 1999 Dec; 291(3):1348-55. PMID: 10565860.
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    130. Ranganathan S, Ciaccio PJ, Walsh ES, Tew KD. Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation. Gene. 1999 Nov 15; 240(1):149-55. PMID: 10564821.
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    131. Adler V, Yin Z, Tew KD, Ronai Z. Role of redox potential and reactive oxygen species in stress signaling. Oncogene. 1999 Nov 01; 18(45):6104-11. PMID: 10557101.
      Citations:    
    132. Shen H, Schultz MP, Tew KD. Glutathione conjugate interactions with DNA-dependent protein kinase. J Pharmacol Exp Ther. 1999 Sep; 290(3):1101-6. PMID: 10454483.
      Citations:    
    133. Tew KD, Ronai Z. GST function in drug and stress response. Drug Resist Updat. 1999 Jun; 2(3):143-147. PMID: 11504484.
      Citations:    
    134. Gaté L, Paul J, Ba GN, Tew KD, Tapiero H. Oxidative stress induced in pathologies: the role of antioxidants. Biomed Pharmacother. 1999 May; 53(4):169-80. PMID: 10392289.
      Citations:    
    135. Adler V, Yin Z, Fuchs SY, Benezra M, Rosario L, Tew KD, Pincus MR, Sardana M, Henderson CJ, Wolf CR, Davis RJ, Ronai Z. Regulation of JNK signaling by GSTp. EMBO J. 1999 Mar 01; 18(5):1321-34. PMID: 10064598.
      Citations:    
    136. Sangrajrang S, Denoulet P, Millot G, Tatoud R, Podgorniak MP, Tew KD, Calvo F, Fellous A. Estramustine resistance correlates with tau over-expression in human prostatic carcinoma cells. Int J Cancer. 1998 Aug 12; 77(4):626-31. PMID: 9679768.
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    137. Shen H, Schultz M, Kruh GD, Tew KD. Increased expression of DNA-dependent protein kinase confers resistance to adriamycin. Biochim Biophys Acta. 1998 Jul 23; 1381(2):131-8. PMID: 9685611.
      Citations:    
    138. Morgan AS, Sanderson PE, Borch RF, Tew KD, Niitsu Y, Takayama T, Von Hoff DD, Izbicka E, Mangold G, Paul C, Broberg U, Mannervik B, Henner WD, Kauvar LM. Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase. Cancer Res. 1998 Jun 15; 58(12):2568-75. PMID: 9635580.
      Citations:    
    139. Tapiero H, Gaté L, Dhalluin S, Nguyen Ba G, Soupramanien V, Kouyate J, Tew KD. The antioxidant effects of Crassostrea gigas extract (JCOE) in human volunteers. In Vivo. 1998 May-Jun; 12(3):305-9. PMID: 9706475.
      Citations:    
    140. Gaté L, Schultz M, Walsh E, Dhalluin S, Nguyen Ba G, Tapiero H, Tew KD. Impact of dietary supplement of Crassostrea gigas extract (JCOE) on glutathione levels and glutathione S-transferase activity in rat tissues. In Vivo. 1998 May-Jun; 12(3):299-303. PMID: 9706474.
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    141. Tew KD, O'Brien M, Laing NM, Shen H. Coordinate changes in expression of protective genes in drug-resistant cells. Chem Biol Interact. 1998 Apr 24; 111-112:199-211. PMID: 9679555.
      Citations:    
    142. Laing NM, Belinsky MG, Kruh GD, Bell DW, Boyd JT, Barone L, Testa JR, Tew KD. Amplification of the ATP-binding cassette 2 transporter gene is functionally linked with enhanced efflux of estramustine in ovarian carcinoma cells. Cancer Res. 1998 Apr 01; 58(7):1332-7. PMID: 9537224.
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    143. Sangrajrang S, Denoulet P, Laing NM, Tatoud R, Millot G, Calvo F, Tew KD, Fellous A. Association of estramustine resistance in human prostatic carcinoma cells with modified patterns of tubulin expression. Biochem Pharmacol. 1998 Feb 01; 55(3):325-31. PMID: 9484799.
      Citations:    
    144. Paul S, Breuninger LM, Tew KD, Shen H, Kruh GD. ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14976. PMID: 9556431.
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    145. Laing N, Dahllöf B, Hartley-Asp B, Ranganathan S, Tew KD. Interaction of estramustine with tubulin isotypes. Biochemistry. 1997 Jan 28; 36(4):871-8. PMID: 9020786.
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    146. Shen H, Kauvar L, Tew KD. Importance of glutathione and associated enzymes in drug response. Oncol Res. 1997; 9(6-7):295-302. PMID: 9406235.
      Citations:    
    147. Ciaccio PJ, Walsh ES, Tew KD. Promoter analysis of a human dihydrodiol dehydrogenase. Biochem Biophys Res Commun. 1996 Nov 12; 228(2):524-9. PMID: 8920946.
      Citations:    
    148. Paul S, Breuninger LM, Tew KD, Shen H, Kruh GD. ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter. Proc Natl Acad Sci U S A. 1996 Jul 09; 93(14):6929-34. PMID: 8692921.
      Citations:    
    149. Ciaccio PJ, Tew KD. Adaptive response to glutathione S-transferase inhibitors. Br J Cancer Suppl. 1996 Jul; 27:S93-8. PMID: 8763856.
      Citations:    
    150. Tew KD, Monks A, Barone L, Rosser D, Akerman G, Montali JA, Wheatley JB, Schmidt DE. Glutathione-associated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program. Mol Pharmacol. 1996 Jul; 50(1):149-59. PMID: 8700107.
      Citations:    
    151. Ranganathan S, Dexter DW, Benetatos CA, Chapman AE, Tew KD, Hudes GR. Increase of beta(III)- and beta(IVa)-tubulin isotopes in human prostate carcinoma cells as a result of estramustine resistance. Cancer Res. 1996 Jun 01; 56(11):2584-9. PMID: 8653701.
      Citations:    
    152. O'Brien ML, Tew KD. Glutathione and related enzymes in multidrug resistance. Eur J Cancer. 1996 Jun; 32A(6):967-78. PMID: 8763337.
      Citations:    
    153. Shen H, Paul S, Breuninger LM, Ciaccio PJ, Laing NM, Helt M, Tew KD, Kruh GD. Cellular and in vitro transport of glutathione conjugates by MRP. Biochemistry. 1996 May 07; 35(18):5719-25. PMID: 8639531.
      Citations:    
    154. Ciaccio PJ, Shen H, Kruh GD, Tew KD. Effects of chronic ethacrynic acid exposure on glutathione conjugation and MRP expression in human colon tumor cells. Biochem Biophys Res Commun. 1996 May 06; 222(1):111-5. PMID: 8630053.
      Citations:    
    155. Schröder CP, Godwin AK, O'Dwyer PJ, Tew KD, Hamilton TC, Ozols RF. Glutathione and drug resistance. Cancer Invest. 1996; 14(2):158-68. PMID: 8597901.
      Citations:    
    156. Raha A, Tew KD. Glutathione S-transferases. Cancer Treat Res. 1996; 87:83-122. PMID: 8886450.
      Citations:    
    157. Tapiero H, Tew KD. Increased glutathione expression in cells induced by Crassostera gigas extract (JCOE). Biomed Pharmacother. 1996; 50(3-4):149-53. PMID: 8881371.
      Citations:    
    158. Morgan AS, Ciaccio PJ, Tew KD, Kauvar LM. Isozyme-specific glutathione S-transferase inhibitors potentiate drug sensitivity in cultured human tumor cell lines. Cancer Chemother Pharmacol. 1996; 37(4):363-70. PMID: 8548883.
      Citations:    
    159. Shen H, Ranganathan S, Kuzmich S, Tew KD. Influence of ethacrynic acid on glutathione S-transferase pi transcript and protein half-lives in human colon cancer cells. Biochem Pharmacol. 1995 Oct 12; 50(8):1233-8. PMID: 7488239.
      Citations:    
    160. Ciaccio PJ, Shen H, Jaiswal AK, Lyttle MH, Tew KD. Modulation of detoxification gene expression in human colon HT29 cells by glutathione-S-transferase inhibitors. Mol Pharmacol. 1995 Oct; 48(4):639-47. PMID: 7476889.
      Citations:    
    161. Ranganathan S, Walsh ES, Tew KD. Glyoxalase I in detoxification: studies using a glyoxalase I transfectant cell line. Biochem J. 1995 Jul 01; 309 ( Pt 1):127-31. PMID: 7619046.
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    162. Smith CD, Zilfou JT, Zhang X, Hudes GR, Tew KD. Modulation of P-glycoprotein activity by estramustine is limited by binding to plasma proteins. Cancer. 1995 May 15; 75(10):2597-604. PMID: 7736407.
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    163. O'Dwyer PJ, Hamilton TC, Yao KS, Tew KD, Ozols RF. Modulation of glutathione and related enzymes in reversal of resistance to anticancer drugs. Hematol Oncol Clin North Am. 1995 Apr; 9(2):383-96. PMID: 7642469.
      Citations:    
    164. Speicher LA, Laing N, Barone LR, Robbins JD, Seamon KB, Tew KD. Interaction of an estramustine photoaffinity analogue with cytoskeletal proteins in prostate carcinoma cells. Mol Pharmacol. 1994 Nov; 46(5):866-72. PMID: 7969073.
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    165. Lacreta FP, Brennan JM, Nash SL, Comis RL, Tew KD, O'Dwyer PJ. Pharmakokinetics and bioavailability study of ethacrynic acid as a modulator of drug resistance in patients with cancer. J Pharmacol Exp Ther. 1994 Sep; 270(3):1186-91. PMID: 7932170.
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    166. Tew KD. Glutathione-associated enzymes in anticancer drug resistance. Cancer Res. 1994 Aug 15; 54(16):4313-20. PMID: 8044778.
      Citations:    
    167. Ciaccio PJ, Tew KD. cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase. Biochim Biophys Acta. 1994 Jun 28; 1186(1-2):129-32. PMID: 8011662.
      Citations:    
    168. Ciaccio PJ, Jaiswal AK, Tew KD. Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics. J Biol Chem. 1994 Jun 03; 269(22):15558-62. PMID: 7515059.
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    169. Speicher LA, Barone LR, Chapman AE, Hudes GR, Laing N, Smith CD, Tew KD. P-glycoprotein binding and modulation of the multidrug-resistant phenotype by estramustine. J Natl Cancer Inst. 1994 May 04; 86(9):688-94. PMID: 7908988.
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    170. Ranganathan S, Tew KD. Analysis of glyoxalase-I from normal and tumor tissue from human colon. Biochim Biophys Acta. 1993 Oct 20; 1182(3):311-6. PMID: 8399366.
      Citations:    
    171. Ciaccio PJ, Stuart JE, Tew KD. Overproduction of a 37.5-kDa cytosolic protein structurally related to prostaglandin F synthase in ethacrynic acid-resistant human colon cells. Mol Pharmacol. 1993 Jun; 43(6):845-53. PMID: 8316217.
      Citations:    
    172. Ranganathan S, Walsh ES, Godwin AK, Tew KD. Cloning and characterization of human colon glyoxalase-I. J Biol Chem. 1993 Mar 15; 268(8):5661-7. PMID: 8449929.
      Citations:    
    173. Clapper ML, Kuzmich S, Seestaller LM, Tew KD. Time course of glutathione S-transferase elevation in Walker mammary carcinoma cells following chlorambucil exposure. Biochem Pharmacol. 1993 Feb 09; 45(3):683-90. PMID: 7680202.
      Citations:    
    174. Tew KD, Glusker JP, Hartley-Asp B, Hudes G, Speicher LA. Preclinical and clinical perspectives on the use of estramustine as an antimitotic drug. Pharmacol Ther. 1992 Dec; 56(3):323-39. PMID: 1301594.
      Citations:    
    175. Hudes GR, Greenberg R, Krigel RL, Fox S, Scher R, Litwin S, Watts P, Speicher L, Tew K, Comis R. Phase II study of estramustine and vinblastine, two microtubule inhibitors, in hormone-refractory prostate cancer. J Clin Oncol. 1992 Nov; 10(11):1754-61. PMID: 1383436.
      Citations:    
    176. Speicher LA, Barone L, Tew KD. Combined antimicrotubule activity of estramustine and taxol in human prostatic carcinoma cell lines. Cancer Res. 1992 Aug 15; 52(16):4433-40. PMID: 1353706.
      Citations:    
    177. Schisselbauer JC, Hogan WM, Buetow KH, Tew KD. Heterogeneity of glutathione S-transferase enzyme and gene expression in ovarian carcinoma. Pharmacogenetics. 1992 Apr; 2(2):63-72. PMID: 1363817.
      Citations:    
    178. Punzi JS, Duax WL, Strong P, Griffin JF, Flocco MM, Zacharias DE, Carrell HL, Tew KD, Glusker JP. Molecular conformation of estramustine and two analogues. Mol Pharmacol. 1992 Mar; 41(3):569-76. PMID: 1545778.
      Citations:    
    179. O'Dwyer PJ, Hamilton TC, Young RC, LaCreta FP, Carp N, Tew KD, Padavic K, Comis RL, Ozols RF. Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results. J Natl Cancer Inst. 1992 Feb 19; 84(4):264-7. PMID: 1734088.
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    180. Kuzmich S, Vanderveer LA, Walsh ES, LaCreta FP, Tew KD. Increased levels of glutathione S-transferase pi transcript as a mechanism of resistance to ethacrynic acid. Biochem J. 1992 Jan 01; 281 ( Pt 1):219-24. PMID: 1731759.
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    181. Ranganathan S, Tew KD. Immunohistochemical localization of glutathione S-transferases alpha, mu, and pi in normal tissue and carcinomas from human colon. Carcinogenesis. 1991 Dec; 12(12):2383-7. PMID: 1747943.
      Citations:    
    182. O'Dwyer PJ, LaCreta F, Nash S, Tinsley PW, Schilder R, Clapper ML, Tew KD, Panting L, Litwin S, Comis RL, et al. Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid. Cancer Res. 1991 Nov 15; 51(22):6059-65. PMID: 1933869.
      Citations:    
    183. Clapper ML, Hoffman SJ, Carp N, Watts P, Seestaller LM, Weese JL, Tew KD. Contribution of patient history to the glutathione S-transferase activity of human lung, breast and colon tissue. Carcinogenesis. 1991 Oct; 12(10):1957-61. PMID: 1934278.
      Citations:    
    184. Ciaccio PJ, Tew KD, LaCreta FP. Enzymatic conjugation of chlorambucil with glutathione by human glutathione S-transferases and inhibition by ethacrynic acid. Biochem Pharmacol. 1991 Sep 12; 42(7):1504-7. PMID: 1930278.
      Citations:    
    185. Morris DI, Speicher LA, Ruoho AE, Tew KD, Seamon KB. Interaction of forskolin with the P-glycoprotein multidrug transporter. Biochemistry. 1991 Aug 27; 30(34):8371-9. PMID: 1679346.
      Citations:    
    186. Speicher LA, Sheridan VR, Godwin AK, Tew KD. Resistance to the antimitotic drug estramustine is distinct from the multidrug resistant phenotype. Br J Cancer. 1991 Aug; 64(2):267-73. PMID: 1892755.
      Citations:    
    187. Kuzmich S, Vanderveer LA, Tew KD. Evidence for a glycoconjugate form of glutathione S-transferase pI. Int J Pept Protein Res. 1991 Jun; 37(6):565-71. PMID: 1717393.
      Citations:    
    188. Clapper ML, Hoffman SJ, Tew KD. Glutathione S-transferases in normal and malignant human colon tissue. Biochim Biophys Acta. 1991 Apr 15; 1096(3):209-16. PMID: 2018794.
      Citations:    
    189. Sheridan VR, Speicher LA, Tew KD. The effects of estramustine on metaphase and anaphase in DU 145 prostatic carcinoma cells. Eur J Cell Biol. 1991 Apr; 54(2):268-76. PMID: 1879438.
      Citations:    
    190. Kuzmich S, Tew KD. Detoxification mechanisms and tumor cell resistance to anticancer drugs. Med Res Rev. 1991 Mar; 11(2):185-217. PMID: 2020229.
      Citations:    
    191. Sheridan VR, Tew KD. Mechanism based chemotherapy for prostate cancer. Cancer Surv. 1991; 11:239-54. PMID: 1841754.
      Citations:    
    192. Schisselbauer JC, Silber R, Papadopoulos E, Abrams K, LaCreta FP, Tew KD. Characterization of glutathione S-transferase expression in lymphocytes from chronic lymphocytic leukemia patients. Cancer Res. 1990 Jun 15; 50(12):3562-8. PMID: 2340505.
      Citations:    
    193. Fujiwara Y, Sugimoto Y, Kasahara K, Bungo M, Yamakido M, Tew KD, Saijo N. Determinants of drug response in a cisplatin-resistant human lung cancer cell line. Jpn J Cancer Res. 1990 May; 81(5):527-35. PMID: 2116401.
      Citations:    
    194. Nakagawa K, Saijo N, Tsuchida S, Sakai M, Tsunokawa Y, Yokota J, Muramatsu M, Sato K, Terada M, Tew KD. Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines. J Biol Chem. 1990 Mar 15; 265(8):4296-301. PMID: 2407735.
      Citations:    
    195. Ciaccio PJ, Tew KD, LaCreta FP. The spontaneous and glutathione S-transferase-mediated reaction of chlorambucil with glutathione. Cancer Commun. 1990; 2(8):279-85. PMID: 2390420.
      Citations:    
    196. Tapiero H, Yin MB, Catalin J, Paraire M, Deloffre P, Rustum Y, Bizzari JP, Tew KD. Cytotoxicity and DNA damaging effects of a new nitrosourea, fotemustine, diethyl- 1-(3-(2-chloroethyl)-3-nitrosoureido) ethylphosphonate-S10036. Anticancer Res. 1989 Nov-Dec; 9(6):1617-22. PMID: 2627116.
      Citations:    
    197. Clapper ML, Tew KD. Identification of a glutathione S-transferase associated with microsomes of tumor cells resistant to nitrogen mustards. Biochem Pharmacol. 1989 Jun 15; 38(12):1915-21. PMID: 2742599.
      Citations:    
    198. Schisselbauer JC, Crescimanno M, D'Alessandro N, Clapper M, Toulmond S, Tapiero H, Tew KD. Glutathione, glutathione S-transferases, and related redox enzymes in Adriamycin-resistant cell lines with a multidrug resistant phenotype. Cancer Commun. 1989; 1(2):133-9. PMID: 2639724.
      Citations:    
    199. Tew KD, Stearns ME. Intracellular effects of estramustine (Estracyt/Emcyt). Prog Clin Biol Res. 1989; 303:169-75. PMID: 2674983.
      Citations:    
    200. Tew KD, Stearns ME. Estramustine--a nitrogen mustard/steroid with antimicrotubule activity. Pharmacol Ther. 1989; 43(3):299-319. PMID: 2682681.
      Citations:    
    201. LaCreta FP, Olszewski JJ, Tew KD. Purification of glutathione S-transferases from rat liver and Walker 256 mammary carcinoma cells by high-performance liquid chromatography and a glutathione affinity column. J Chromatogr. 1988 Dec 29; 434(1):83-93. PMID: 3243838.
      Citations:    
    202. Stearns ME, Wang M, Tew KD, Binder LI. Estramustine binds a MAP-1-like protein to inhibit microtubule assembly in vitro and disrupt microtubule organization in DU 145 cells. J Cell Biol. 1988 Dec; 107(6 Pt 2):2647-56. PMID: 3060470.
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    203. Tew KD, Bomber AM, Hoffman SJ. Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines. Cancer Res. 1988 Jul 01; 48(13):3622-5. PMID: 3288331.
      Citations:    
    204. Stearns ME, Tew KD. Estramustine binds MAP-2 to inhibit microtubule assembly in vitro. J Cell Sci. 1988 Mar; 89 ( Pt 3):331-42. PMID: 3198696.
      Citations:    
    205. Wang M, Tew KD, Stearns ME. Immunofluorescent studies of the anti-microtubule effects of the anti-cancer drug estramustine. Anticancer Res. 1987 Nov-Dec; 7(6):1165-71. PMID: 3327449.
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    206. Tew KD, Clapper ML, Greenberg RE, Weese JL, Hoffman SJ, Smith TM. Glutathione S-transferases in human prostate. Biochim Biophys Acta. 1987 Oct 08; 926(1):8-15. PMID: 2443182.
      Citations:    
    207. Buller AL, Clapper ML, Tew KD. Glutathione S-transferases in nitrogen mustard-resistant and -sensitive cell lines. Mol Pharmacol. 1987 Jun; 31(6):575-8. PMID: 3600602.
      Citations:    
    208. Tew KD, Stearns ME. Hormone-independent, non-alkylating mechanism of cytotoxicity for estramustine. Urol Res. 1987; 15(3):155-60. PMID: 3307087.
      Citations:    
    209. Moy BC, Tew KD. Differences in the nuclear matrix phosphoproteins of a wild-type and nitrogen mustard-resistant rat breast carcinoma cell line. Cancer Res. 1986 Sep; 46(9):4672-6. PMID: 3015392.
      Citations:    
    210. Dean SW, Gibson NW, Tew KD. Selection of nitrogen mustard resistance in a rat tumor cell line results in loss of guanine-O6-alkyl transferase activity. Mol Pharmacol. 1986 Jul; 30(1):77-80. PMID: 3724747.
      Citations:    
    211. Tew KD, Woodworth A, Stearns ME. Relationship of glutathione depletion and inhibition of glutathione-S-transferase activity to the antimitotic properties of estramustine. Cancer Treat Rep. 1986 Jun; 70(6):715-20. PMID: 3731136.
      Citations:    
    212. Dean SW, Johnson AB, Tew KD. A comparative analysis of drug-induced DNA effects in a nitrogen mustard resistant cell line expressing sensitivity to nitrosoureas. Biochem Pharmacol. 1986 Apr 01; 35(7):1171-6. PMID: 2938589.
      Citations:    
    213. Stearns ME, Jenkins DP, Tew KD. Dansylated estramustine, a fluorescent probe for studies of estramustine uptake and identification of intracellular targets. Proc Natl Acad Sci U S A. 1985 Dec; 82(24):8483-7. PMID: 3866236.
      Citations:    
    214. Stearns ME, Tew KD. Antimicrotubule effects of estramustine, an antiprostatic tumor drug. Cancer Res. 1985 Aug; 45(8):3891-7. PMID: 4016756.
      Citations:    
    215. Moy BC, Tew KD. Poly(adenosine diphosphate-ribosylation) of nuclear matrix proteins in alkylating agent resistant and sensitive cell lines. Chem Biol Interact. 1985 Jul; 54(2):209-22. PMID: 2992825.
      Citations:    
    216. Wang AL, Tew KD. Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards. Cancer Treat Rep. 1985 Jun; 69(6):677-82. PMID: 4016771.
      Citations:    
    217. Tew KD, Kyle G, Johnson A, Wang AL. Carbamoylation of glutathione reductase and changes in cellular and chromosome morphology in a rat cell line resistant to nitrogen mustards but collaterally sensitive to nitrosoureas. Cancer Res. 1985 May; 45(5):2326-33. PMID: 3986776.
      Citations:    
    218. Lown JW, Koganty RR, Tew KD, Oiry J, Imbach JL. Mechanism of action of 2-haloethylnitrosoureas on deoxyribonucleic acid. Pathways of aqueous decomposition and pharmacological characteristics of new anticancer disulfide-linked nitrosoureas. Biochem Pharmacol. 1985 Apr 01; 34(7):1015-24. PMID: 3985988.
      Citations:    
    219. Farhi JJ, Bennoun M, Tapiero H, Wang AL, Tew KD. Biochemical and cytotoxic properties of the isomeric forms of N,N'-bis[N-2-chloroethyl)-N-nitrosocarbamoyl] cystamine. Biochem Pharmacol. 1984 Aug 15; 33(16):2575-80. PMID: 6466373.
      Citations:    
    220. Tew KD, Hartley-Asp B. Cytotoxic properties of estramustine unrelated to alkylating and steroid constituents. Urology. 1984 Jun; 23(6 Suppl):28-33. PMID: 6730140.
      Citations:    
    221. Tew KD, Wang AL, Schein PS. Alkylating agent interactions with the nuclear matrix. Biochem Pharmacol. 1983 Dec 01; 32(23):3509-16. PMID: 6228232.
      Citations:    
    222. Tew KD, Erickson LC, White G, Wang AL, Schein PS, Hartley-Asp B. Cytotoxicity of estramustine, a steroid-nitrogen mustard derivative, through non-DNA targets. Mol Pharmacol. 1983 Sep; 24(2):324-8. PMID: 6888373.
      Citations:    
    223. Tew KD. The mechanism of action of estramustine. Semin Oncol. 1983 Sep; 10(3 Suppl 3):21-6. PMID: 6364362.
      Citations:    
    224. Ahlgren JD, Green DC, Tew KD, Schein PS. Repair of DNA alkylation induced in L1210 leukemia and murine bone marrow by three chloroethylnitrosoureas. Cancer Res. 1982 Jul; 42(7):2605-8. PMID: 6211225.
      Citations:    
    225. Green D, Tew KD, Hisamatsu T, Schein PS. Correlation of nitrosourea murine bone marrow toxicity with deoxyribonucleic acid alkylation and chromatin binding sites. Biochem Pharmacol. 1982 May 01; 31(9):1671-9. PMID: 7104031.
      Citations:    
    226. Tew KD, Wang AL. Selective cytotoxicity of haloethylnitrosoureas in a carcinoma cell line resistant to bifunctional nitrogen mustards. Mol Pharmacol. 1982 May; 21(3):729-38. PMID: 7110120.
      Citations:    
    227. Tew KD, Wang AL, Lindner DJ, Schein PS. Enhancement of nitrosourea cytotoxicity in vitro using hydrocortisone. Biochem Pharmacol. 1982 Mar 15; 31(6):1179-80. PMID: 7082372.
      Citations:    
    228. Tew KD, Schein PS, Lindner DJ, Wang AL, Smulson ME. Influence of hydrocortisone on the binding of nitrosoureas to nuclear chromatin subfractions. Cancer Res. 1980 Oct; 40(10):3697-3703. PMID: 7438052.
      Citations:    
    229. Tew KD, Taylor DM. Cyclophosphamide and cis-dichlorodiammine platinum (11). Nonempiric scheduling to spare dose-limiting tissues in the rat. Cancer Chemother Pharmacol. 1980; 4(2):103-9. PMID: 7190083.
      Citations:    
    230. Sudhakar S, Tew KD, Smulson ME. Effect of 1-methyl-1-nitrosourea on poly(adenosine diphosphate-ribose) polymerase activity at the nucleosomal level. Cancer Res. 1979 Apr; 39(4):1405-10. PMID: 217534.
      Citations:    
    231. Sudhakar S, Tew KD, Schein PS, Woolley PV, Smulson ME. Nitrosourea interaction with chromatin and effect on poly(adenosine diphosphate ribose) polymerase activity. Cancer Res. 1979 Apr; 39(4):1411-7. PMID: 217535.
      Citations:    
    232. Pinsky SD, Tew KD, Smulson ME, Woolley PV. Modification of L1210 cell nuclear proteins by 1-methyl-1-nitrosourea and 1-methyl-3-nitro-1-nitrosoguanidine. Cancer Res. 1979 Mar; 39(3):923-8. PMID: 427780.
      Citations:    
    233. Tew KD, Sudhakar S, Schein PS, Smulson ME. Binding of chlorozotocin and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea to chromatin and nucleosomal fractions of HeLa cells. Cancer Res. 1978 Oct; 38(10):3371-8. PMID: 150941.
      Citations:    
    234. Tew KD, Taylor DM. The relationship of thymidine metabolism to the use of fractional incorporation as a measure of DNA synthesis and tissue proliferation. Eur J Cancer. 1978 Feb; 14(2):153-68. PMID: 624312.
      Citations:    
    235. Taylor DM, Tew KD, Jones JD. Effects of cis-dichlorodiammine platinum (II) on DNA synthesis in kidney and other tissues of normal and tumour-bearing rats. Eur J Cancer. 1976 Apr; 12(4):249-54. PMID: 954790.
      Citations:    
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