Keywords
Last Name
Institution

Charles D. Smith

Title
InstitutionMedical University of South Carolina
DepartmentPediatric Surgery
AddressP.O. Box MSC 613
417
96 Jonathan Lucas St.
Phone843-792-3851
Fax843-792-3858
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    Collapse Overview 
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    C. D. Smith, a native of Memphis, Tennessee, is a tenured Associate Professor of Surgery and Pediatrics at MUSC, having been a faculty member continuously since 1978. His background includes an undergraduate degree from Princeton, an MD from Duke and a Masters of Science from the Center for Evaluative Sciences at Dartmouth College obtained during a sabbatical 1997 – 1998. After two years of pediatrics residency at Duke and at the University of Tennessee, he completed general surgery residency at the University of Tennessee and fellowship in pediatric surgery at Harvard (Boston Children’s Hospital). He served six years as the Medical Director for Quality for the University Hospital 1995 – 2001. Currently his chief interests are clinical care with an emphasis on minimally invasive surgery and teaching.
    Collapse keywords
    imperforate anus, congenital anterior abdominal wall defects, bioethics, quality improvement in healthcare, pediatric burns, minimally invasive pediatric surgery

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Britten CD, Garrett-Mayer E, Chin SH, Shirai K, Ogretmen B, Bentz TA, Brisendine A, Anderton K, Cusack SL, Maines LW, Zhuang Y, Smith CD, Thomas MB. A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors. Clin Cancer Res. 2017 Aug 15; 23(16):4642-4650. PMID: 28420720.
      View in: PubMed
    2. Sommer G, Fedarovich A, Kota V, Rodriguez R, Smith CD, Heise T. Applying a high-throughput fluorescence polarization assay for the discovery of chemical probes blocking La:RNA interactions in vitro and in cells. PLoS One. 2017; 12(3):e0173246. PMID: 28291789.
      View in: PubMed
    3. Lewis CS, Voelkel-Johnson C, Smith CD. Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640. Oncotarget. 2016 Sep 13; 7(37):60181-60192. PMID: 27517489.
      View in: PubMed
    4. Ding X, Chaiteerakij R, Moser CD, Shaleh H, Boakye J, Chen G, Ndzengue A, Li Y, Zhou Y, Huang S, Sinicrope FA, Zou X, Thomas MB, Smith CD, Roberts LR. Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells. Oncotarget. 2016 Apr 12; 7(15):20080-92. PMID: 26956050.
      View in: PubMed
    5. Jones EE, Gao P, Smith CD, Norris JS, Drake RR. Tissue biomarkers of drug efficacy: case studies using a MALDI-MSI workflow. Bioanalysis. 2015; 7(20):2611-9. PMID: 26505686.
      View in: PubMed
    6. Venant H, Rahmaniyan M, Jones EE, Lu P, Lilly MB, Garrett-Mayer E, Drake RR, Kraveka JM, Smith CD, Voelkel-Johnson C. The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo. . 2015 Dec; 14(12):2744-52. PMID: 26494858.
      View in: PubMed
    7. Schrecengost RS, Keller SN, Schiewer MJ, Knudsen KE, Smith CD. Downregulation of Critical Oncogenes by the Selective SK2 Inhibitor ABC294640 Hinders Prostate Cancer Progression. Mol Cancer Res. 2015 Dec; 13(12):1591-601. PMID: 26271487.
      View in: PubMed
    8. Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Sci Signal. 2015 Jun 16; 8(381):ra58. PMID: 26082434.
      View in: PubMed
    9. Qin Z, Dai L, Trillo-Tinoco J, Senkal C, Wang W, Reske T, Bonstaff K, Del Valle L, Rodriguez P, Flemington E, Voelkel-Johnson C, Smith CD, Ogretmen B, Parsons C. Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. . 2014 Jan; 13(1):154-64. PMID: 24140934.
      View in: PubMed
    10. Schwartz J, Holmuhamedov E, Zhang X, Lovelace GL, Smith CD, Lemasters JJ. Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia/reperfusion injury by inhibition of the mitochondrial calcium uniporter. Toxicol Appl Pharmacol. 2013 Nov 15; 273(1):172-9. PMID: 24012766.
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    11. Russell WS, Schuh AM, Hill JG, Hebra A, Cina RA, Smith CD, Streck CJ. Clinical practice guidelines for pediatric appendicitis evaluation can decrease computed tomography utilization while maintaining diagnostic accuracy. Pediatr Emerg Care. 2013 May; 29(5):568-73. PMID: 23611916.
      View in: PubMed
    12. Gao P, Peterson YK, Smith RA, Smith CD. Characterization of isoenzyme-selective inhibitors of human sphingosine kinases. PLoS One. 2012; 7(9):e44543. PMID: 22970244.
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    13. Baker DA, Eudaly J, Smith CD, Obeid LM, Gilkeson GS. Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis. Rheumatol Int. 2013 Oct; 33(10):2677-81. PMID: 23011090.
      View in: PubMed
    14. Liu Q, Rehman H, Shi Y, Krishnasamy Y, Lemasters JJ, Smith CD, Zhong Z. Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. PLoS One. 2012; 7(7):e41834. PMID: 22848628.
      View in: PubMed
    15. Sun WY, Abeynaike LD, Escarbe S, Smith CD, Pitson SM, Hickey MJ, Bonder CS. Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent. Am J Pathol. 2012 Apr; 180(4):1740-50. PMID: 22322303.
      View in: PubMed
    16. Gao P, Smith CD. Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration. Mol Cancer Res. 2011 Nov; 9(11):1509-19. PMID: 21896638.
      View in: PubMed
    17. Draper JM, Xia Z, Smith RA, Zhuang Y, Wang W, Smith CD. Discovery and evaluation of inhibitors of human ceramidase. . 2011 Nov; 10(11):2052-61. PMID: 21885864.
      View in: PubMed
    18. Shi Y, Rehman H, Ramshesh VK, Schwartz J, Liu Q, Krishnasamy Y, Zhang X, Lemasters JJ, Smith CD, Zhong Z. Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. J Hepatol. 2012 Jan; 56(1):137-45. PMID: 21756852.
      View in: PubMed
    19. Gangjee A, Namjoshi OA, Keller SN, Smith CD. 2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance. Bioorg Med Chem. 2011 Jul 15; 19(14):4355-65. PMID: 21680190.
      View in: PubMed
    20. Antoon JW, White MD, Slaughter EM, Driver JL, Khalili HS, Elliott S, Smith CD, Burow ME, Beckman BS. Targeting NF?B mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2. . 2011 Apr 01; 11(7):678-89. PMID: 21307639.
      View in: PubMed
    21. Beljanski V, Lewis CS, Smith CD. Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. . 2011 Mar 01; 11(5):524-34. PMID: 21258214.
      View in: PubMed
    22. Beharry Z, Mahajan S, Zemskova M, Lin YW, Tholanikunnel BG, Xia Z, Smith CD, Kraft AS. The Pim protein kinases regulate energy metabolism and cell growth. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):528-33. PMID: 21187426.
      View in: PubMed
    23. Chumanevich AA, Poudyal D, Cui X, Davis T, Wood PA, Smith CD, Hofseth LJ. Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase. Carcinogenesis. 2010 Oct; 31(10):1787-93. PMID: 20688834.
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    24. McGowan J, Smith CD, Maize J, Cook J. Giant fibrous hamartoma of infancy: a report of two cases and review of the literature. J Am Acad Dermatol. 2011 Mar; 64(3):579-86. PMID: 20598395.
      View in: PubMed
    25. Beljanski V, Knaak C, Zhuang Y, Smith CD. Combined anticancer effects of sphingosine kinase inhibitors and sorafenib. Invest New Drugs. 2011 Dec; 29(6):1132-42. PMID: 20473784.
      View in: PubMed
    26. Draper JM, Smith CD. DHHC20: a human palmitoyl acyltransferase that causes cellular transformation. Mol Membr Biol. 2010 Apr; 27(2-3):123-36. PMID: 20334580.
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    27. Beljanski V, Knaak C, Smith CD. A novel sphingosine kinase inhibitor induces autophagy in tumor cells. J Pharmacol Exp Ther. 2010 May; 333(2):454-64. PMID: 20179157.
      View in: PubMed
    28. French KJ, Zhuang Y, Maines LW, Gao P, Wang W, Beljanski V, Upson JJ, Green CL, Keller SN, Smith CD. Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. J Pharmacol Exp Ther. 2010 Apr; 333(1):129-39. PMID: 20061445.
      View in: PubMed
    29. Xia Z, Draper JM, Smith CD. Improved synthesis of a fluorogenic ceramidase substrate. Bioorg Med Chem. 2010 Feb; 18(3):1003-9. PMID: 20085856.
      View in: PubMed
    30. Katz SI, Zhou L, Chao G, Smith CD, Ferrara T, Wang W, Dicker DT, El-Deiry WS. Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma. . 2009 Dec; 8(24):2406-16. PMID: 20038816.
      View in: PubMed
    31. Lin YW, Beharry ZM, Hill EG, Song JH, Wang W, Xia Z, Zhang Z, Aplan PD, Aster JC, Smith CD, Kraft AS. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 Jan 28; 115(4):824-33. PMID: 19965690.
      View in: PubMed
    32. Beharry Z, Zemskova M, Mahajan S, Zhang F, Ma J, Xia Z, Lilly M, Smith CD, Kraft AS. Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells. . 2009 Jun; 8(6):1473-83. PMID: 19509254.
      View in: PubMed
    33. Zhang F, Beharry ZM, Harris TE, Lilly MB, Smith CD, Mahajan S, Kraft AS. PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells. . 2009 May; 8(9):846-53. PMID: 19276681.
      View in: PubMed
    34. Draper JM, Smith CD. Palmitoyl acyltransferase assays and inhibitors (Review). Mol Membr Biol. 2009 Jan; 26(1):5-13. PMID: 19152182.
      View in: PubMed
    35. Xia Z, Knaak C, Ma J, Beharry ZM, McInnes C, Wang W, Kraft AS, Smith CD. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem. 2009 Jan 08; 52(1):74-86. PMID: 19072652.
      View in: PubMed
    36. Tran MA, Smith CD, Kester M, Robertson GP. Combining nanoliposomal ceramide with sorafenib synergistically inhibits melanoma and breast cancer cell survival to decrease tumor development. Clin Cancer Res. 2008 Jun 01; 14(11):3571-81. PMID: 18519791.
      View in: PubMed
    37. Lesher AP, Kratz JM, Smith CD. Removal of embedded central venous catheters. J Pediatr Surg. 2008 Jun; 43(6):1030-4. PMID: 18558178.
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    38. Maines LW, Fitzpatrick LR, French KJ, Zhuang Y, Xia Z, Keller SN, Upson JJ, Smith CD. Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase. Dig Dis Sci. 2008 Apr; 53(4):997-1012. PMID: 18058233.
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    39. Ricci MS, Kim SH, Ogi K, Plastaras JP, Ling J, Wang W, Jin Z, Liu YY, Dicker DT, Chiao PJ, Flaherty KT, Smith CD, El-Deiry WS. Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death. Cancer Cell. 2007 Jul; 12(1):66-80. PMID: 17613437.
      View in: PubMed
    40. Gangjee A, Yu J, Copper JE, Smith CD. Discovery of novel antitumor antimitotic agents that also reverse tumor resistance. J Med Chem. 2007 Jul 12; 50(14):3290-301. PMID: 17567121.
      View in: PubMed
    41. Draper JM, Xia Z, Smith CD. Cellular palmitoylation and trafficking of lipidated peptides. J Lipid Res. 2007 Aug; 48(8):1873-84. PMID: 17525474.
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    42. Ducker CE, Draper JM, Xia Z, Smith CD. In vitro and cellular assays for palmitoyl acyltransferases using fluorescent lipidated peptides. Methods. 2006 Oct; 40(2):166-70. PMID: 17012028.
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    43. Ducker CE, Griffel LK, Smith RA, Keller SN, Zhuang Y, Xia Z, Diller JD, Smith CD. Discovery and characterization of inhibitors of human palmitoyl acyltransferases. . 2006 Jul; 5(7):1647-59. PMID: 16891450.
      View in: PubMed
    44. Ducker CE, Upson JJ, French KJ, Smith CD. Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. Mol Cancer Res. 2005 Aug; 3(8):463-76. PMID: 16123142.
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    45. Sharma A, Trivedi NR, Zimmerman MA, Tuveson DA, Smith CD, Robertson GP. Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors. Cancer Res. 2005 Mar 15; 65(6):2412-21. PMID: 15781657.
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    46. Upshaw JE, Smith CD, Tagge EP, Evans J. Thermal injury in children. J S C Med Assoc. 2004 Dec; 100(12):342-6. PMID: 15835196.
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    47. Lee BD, Li Z, French KJ, Zhuang Y, Xia Z, Smith CD. Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11; 47(6):1413-22. PMID: 14998330.
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    48. French KJ, Zhuang Y, Schrecengost RS, Copper JE, Xia Z, Smith CD. Cyclohexyl-octahydro-pyrrolo[1,2-a]pyrazine-based inhibitors of human N-myristoyltransferase-1. J Pharmacol Exp Ther. 2004 Apr; 309(1):340-7. PMID: 14724220.
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    49. French KJ, Schrecengost RS, Lee BD, Zhuang Y, Smith SN, Eberly JL, Yun JK, Smith CD. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15; 63(18):5962-9. PMID: 14522923.
      View in: PubMed
    50. Varner AS, Ducker CE, Xia Z, Zhuang Y, De Vos ML, Smith CD. Characterization of human palmitoyl-acyl transferase activity using peptides that mimic distinct palmitoylation motifs. Biochem J. 2003 Jul 01; 373(Pt 1):91-9. PMID: 12670300.
      View in: PubMed
    51. Smith CD, Tecklenburg FW, Habib DM, Hughes MR, Hulsey TC, Ebeling M. Success factors and hurdles in quality improvement in a children's hospital. Semin Pediatr Surg. 2002 Feb; 11(1):12-9. PMID: 11815936.
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    52. Hughes MR, Smith CD, Tecklenburg FW, Habib DM, Hulsey TC, Ebeling M. Effects of a weaning protocol on ventilated pediatric intensive care unit (PICU) patients. Top Health Inf Manage. 2001 Nov; 22(2):35-43. PMID: 11761790.
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    53. Othersen HB, Parker EF, Chandler J, Smith CD, Tagge EP. Save the child's esophagus, Part II: Colic patch repair. J Pediatr Surg. 1997 Feb; 32(2):328-33. PMID: 9044147.
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    54. Othersen HB, Chwals W, Smith CD, Tagge EP, Hebra A. Credentialing of research surgeons: can computers help in the process? J Invest Surg. 1996 May-Jun; 9(3):159-60. PMID: 8957767.
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    55. Othersen HB, Khalil B, Zellner J, Sade R, Handy J, Tagge EP, Smith CD. Aortoesophageal fistula and double aortic arch: two important points in management. J Pediatr Surg. 1996 Apr; 31(4):594-5. PMID: 8801321.
      View in: PubMed
    56. Macpherson RI, Hill JG, Othersen HB, Tagge EP, Smith CD. Esophageal foreign bodies in children: diagnosis, treatment, and complications. AJR Am J Roentgenol. 1996 Apr; 166(4):919-24. PMID: 8610574.
      View in: PubMed
    57. Roberts CS, Othersen HB, Sade RM, Smith CD, Tagge EP, Crawford FA. Tracheoesophageal compression from aortic arch anomalies: analysis of 30 operatively treated children. J Pediatr Surg. 1994 Feb; 29(2):334-7; discussion 337-8. PMID: 8176615.
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    58. Tagge EP, Othersen HB, Jackson SM, Smith CD, Gayoso AJ, Abboud MR, Laver JL, Adams DB. Impact of laparoscopic cholecystectomy on the management of cholelithiasis in children with sickle cell disease. J Pediatr Surg. 1994 Feb; 29(2):209-12; discussion 212-3. PMID: 8176594.
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    59. Tagge EP, Hanson P, Re GG, Othersen HB, Smith CD, Garvin AJ. Paired box gene expression in Wilms' tumor. J Pediatr Surg. 1994 Feb; 29(2):134-41. PMID: 7909843.
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    60. Purohit DM, Swindle MM, Smith CD, Othersen HB, Kazanovicz JM. Hanford miniature swine model for extracorporeal membrane oxygenation. J Invest Surg. 1993 Nov-Dec; 6(6):503-8. PMID: 8123611.
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    61. Othersen HB, Ocampo RJ, Parker EF, Smith CD, Tagge EP. Barrett's esophagus in children. Diagnosis and management. Ann Surg. 1993 Jun; 217(6):676-80; discussion 680-1. PMID: 8507113.
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    62. Campbell BA, Garg RS, Garg K, Garg V, Othersen HB, Smith CD. Perinatal ovarian cyst: a nonsurgical approach. J Pediatr Surg. 1992 Dec; 27(12):1618-9. PMID: 1469596.
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    63. Smith CD, Othersen HB, Gogan NJ, Walker JD. Nissen fundoplication in children with profound neurologic disability. High risks and unmet goals. Ann Surg. 1992 Jun; 215(6):654-8; discussion 658-9. PMID: 1632687.
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    64. Hebra A, Powell DD, Smith CD, Othersen HB. Balloon tracheoplasty in children: results of a 15-year experience. J Pediatr Surg. 1991 Aug; 26(8):957-61. PMID: 1919989.
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    65. Clevenger FW, Othersen HB, Smith CD. Relief of tracheal compression by aortopexy. Ann Thorac Surg. 1990 Oct; 50(4):524-8; discussion 529. PMID: 2222037.
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    66. Othersen HB, Smith CD, Laver J, Morgan S, Abboud M, Garvin AJ. The state of the art in pediatric surgery and pediatric oncology at MUSC Children's Hospital. J S C Med Assoc. 1990 May; 86(5):290-3. PMID: 2342336.
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    67. Powell DM, Othersen HB, Smith CD. Malrotation of the intestines in children: the effect of age on presentation and therapy. J Pediatr Surg. 1989 Aug; 24(8):777-80. PMID: 2769545.
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    68. Warner RL, Othersen HB, Smith CD. Traumatic pancreatitis and pseudocyst in children: current management. J Trauma. 1989 May; 29(5):597-601. PMID: 2657083.
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    69. Othersen HB, Parker EF, Smith CD. The surgical management of esophageal stricture in children. A century of progress. Ann Surg. 1988 May; 207(5):590-7. PMID: 3288139.
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    70. Othersen HB, Smith CD. Pneumatic reduction bag for treatment of gastroschisis and omphalocele. A 10-year experience. Ann Surg. 1986 May; 203(5):512-6. PMID: 2939807.
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    71. Smith CD, Sade RM, Crawford FA, Othersen HB. Diaphragmatic paralysis and eventration in infants. J Thorac Cardiovasc Surg. 1986 Apr; 91(4):490-7. PMID: 3959566.
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    72. Kyong CU, Smith CD, Othersen HB. Necrotizing fasciitis of the abdominal wall as a complication of chickenpox. Pediatr Infect Dis. 1985 Jul-Aug; 4(4):420-1. PMID: 3161008.
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    73. Sens MA, Garvin AJ, Drew S, Smith CD, Othersen HB, Sens DA. Skeletal muscle differentiation in Wilms' tumor. Antibody identification and explant culture. Arch Pathol Lab Med. 1984 Jan; 108(1):58-62. PMID: 6318686.
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    74. Othersen HB, Smith CD. Cancer in children at the medical university hospital: update 1980. J S C Med Assoc. 1980 Mar; 76(3):103-7. PMID: 6929026.
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    75. Othersen HB, Gramling PM, Saad SA, Smith CD. The role of the physician's assistant in a university-based pediatric surgical service. J Pediatr Surg. 1979 Dec; 14(6):789-93. PMID: 45115.
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