Keywords
Last Name
Institution

Steven D. Shapiro

Title
InstitutionMedical University of South Carolina
DepartmentPediatric Dentistry
AddressP.O. Box MSC 507
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Nighot M, Ganapathy AS, Saha K, Suchanec E, Castillo E, Gregory A, Shapiro S, Ma T, Nighot P. Matrix Metalloproteinase MMP-12 promotes macrophage transmigration across intestinal epithelial tight junctions and increases severity of experimental colitis. J Crohns Colitis. 2021 Apr 09. PMID: 33836047.
      View in: PubMed
    2. Li X, Noell G, Tabib T, Gregory AD, Trejo Bittar HE, Vats R, Kaminski TW, Sembrat J, Snyder ME, Chandra D, Chen K, Zou C, Zhang Y, Sundd P, McDyer JF, Sciurba F, Rojas M, Lafyatis R, Shapiro SD, Faner R, Nyunoya T. Single cell RNA sequencing identifies IGFBP5 and QKI as ciliated epithelial cell genes associated with severe COPD. Respir Res. 2021 Apr 06; 22(1):100. PMID: 33823868.
      View in: PubMed
    3. Carleton N, Zou J, Fang Y, Koscumb SE, Shah OS, Chen F, Beriwal S, Diego EJ, Brufsky AM, Oesterreich S, Shapiro SD, Ferris R, Emens LA, Tseng G, Marroquin OC, Lee AV, McAuliffe PF. Outcomes After Sentinel Lymph Node Biopsy and Radiotherapy in Older Women With Early-Stage, Estrogen Receptor-Positive Breast Cancer. JAMA Netw Open. 2021 Apr 01; 4(4):e216322. PMID: 33856473.
      View in: PubMed
    4. Li L, Sun F, Han L, Liu X, Xiao Y, Gregory AD, Shapiro SD, Xiao G, Qu Z. PDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis. JCI Insight. 2021 Mar 08; 6(5). PMID: 33539325.
      View in: PubMed
    5. Bakalov V, Reyes-Uribe L, Deshpande R, Maloy AL, Shapiro SD, Angus DC, Chang CH, Le Moyec L, Wendell SG, Kaynar AM. Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis. PLoS One. 2020; 15(11):e0241122. PMID: 33151963.
      View in: PubMed
    6. Shapiro SD, Boehme AK, Chang BP, Miller EC, Willey J, Elkind MSV. Safety and Hospital Costs Averted Using a Rapid Outpatient Management Strategy for Transient Ischemic Attack and Minor Strokes: The RAVEN Clinic. Neurohospitalist. 2021 Apr; 11(2):107-113. PMID: 33791052.
      View in: PubMed
    7. Radmard S, Epstein SE, Roeder HJ, Michalak AJ, Shapiro SD, Boehme A, Wilson TJ, Duran JC, Bain JM, Willey JZ, Thakur KT. Inpatient Neurology Consultations During the Onset of the SARS-CoV-2 New York City Pandemic: A Single Center Case Series. Front Neurol. 2020; 11:805. PMID: 32754113.
      View in: PubMed
    8. Shapiro SD, Rothman PB. How Academic Health Systems Can Move Forward Once COVID-19 Wanes. JAMA. 2020 Jun 16; 323(23):2377-2378. PMID: 32433764.
      View in: PubMed
    9. Henkel M, Partyka J, Gregory AD, Forno E, Cho MH, Eddens T, Tout AR, Salamacha N, Horne W, Rao KS, Wu Y, Alcorn JF, Kostka D, Hirsch R, Celedón JC, Shapiro SD, Kolls JK, Campfield BT. FSTL-1 Attenuation Causes Spontaneous Smoke-Resistant Pulmonary Emphysema. Am J Respir Crit Care Med. 2020 04 15; 201(8):934-945. PMID: 31834999.
      View in: PubMed
    10. Sun F, Li L, Yan P, Zhou J, Shapiro SD, Xiao G, Qu Z. Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance. Nat Commun. 2019 11 22; 10(1):5324. PMID: 31757943.
      View in: PubMed
    11. Chang BP, Rostanski S, Willey J, Miller EC, Shapiro S, Mehendale R, Kummer B, Navi BB, Elkind MSV. Safety and Feasibility of a Rapid Outpatient Management Strategy for Transient Ischemic Attack and Minor Stroke: The Rapid Access Vascular Evaluation-Neurology (RAVEN) Approach. Ann Emerg Med. 2019 10; 74(4):562-571. PMID: 31326206.
      View in: PubMed
    12. Preston JA, Bewley MA, Marriott HM, McGarry Houghton A, Mohasin M, Jubrail J, Morris L, Stephenson YL, Cross S, Greaves DR, Craig RW, van Rooijen N, Bingle CD, Read RC, Mitchell TJ, Whyte MKB, Shapiro SD, Dockrell DH. Alveolar Macrophage Apoptosis-associated Bacterial Killing Helps Prevent Murine Pneumonia. Am J Respir Crit Care Med. 2019 07 01; 200(1):84-97. PMID: 30649895.
      View in: PubMed
    13. Radder JE, Shapiro SD. Identifying Chronic Obstructive Pulmonary Disease Genes: Shining the Light on Dark DNA. Am J Respir Cell Mol Biol. 2019 Apr; 60(4):373-374. PMID: 30376354.
      View in: PubMed
    14. Shapiro SD, Goldman J, Morgello S, Honig L, Elkind MSV, Marshall RS, Mohr JP, Gutierrez J. Pathological correlates of brain arterial calcifications. Cardiovasc Pathol. 2019 Jan - Feb; 38:7-13. PMID: 30399527.
      View in: PubMed
    15. Mallia-Milanes B, Dufour A, Philp C, Solis N, Klein T, Fischer M, Bolton CE, Shapiro S, Overall CM, Johnson SR. TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations. . 2018 12 01; 315(6):L1003-L1014. PMID: 30284925.
      View in: PubMed
    16. Kinslow CJ, Shapiro SD, Grunebaum MF, Miller EC. Acute hypertensive crisis and severe headache after concurrent use of armodafinil and tranylcypromine: Case report and review of the literature. J Neurol Sci. 2018 10 15; 393:1-3. PMID: 30077942.
      View in: PubMed
    17. Fanjul-Fernández M, Folgueras AR, Fueyo A, Balbín M, Suárez MF, Fernández-García MS, Shapiro SD, Freije JMP, López-Otín C. Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses. J Biol Chem. 2018 07 27; 293(30):11970. PMID: 30054294.
      View in: PubMed
    18. Radder JE, Shapiro SD. Reply to: Quantitative Histology Seriously Flawed by Lack of Lung Volume Measurement. Am J Respir Cell Mol Biol. 2018 02; 58(2):274-275. PMID: 29388831.
      View in: PubMed
    19. Bewley MA, Preston JA, Mohasin M, Marriott HM, Budd RC, Swales J, Collini P, Greaves DR, Craig RW, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Shapiro SD, Whyte MKB, Dockrell DH. Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages. Am J Respir Crit Care Med. 2017 10 01; 196(7):845-855. PMID: 28557543.
      View in: PubMed
    20. Radder JE, Gregory AD, Leme AS, Cho MH, Chu Y, Kelly NJ, Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Beaty TH, Crapo JD, Silverman EK, Zhang Y, Berndt A, Shapiro SD. Variable Susceptibility to Cigarette Smoke-Induced Emphysema in 34 Inbred Strains of Mice Implicates Abi3bp in Emphysema Susceptibility. Am J Respir Cell Mol Biol. 2017 09; 57(3):367-375. PMID: 28441029.
      View in: PubMed
    21. Dandachi N, Kelly NJ, Wood JP, Burton CL, Radder JE, Leme AS, Gregory AD, Shapiro SD. Macrophage Elastase Induces TRAIL-mediated Tumor Cell Death through Its Carboxy-Terminal Domain. Am J Respir Crit Care Med. 2017 08 01; 196(3):353-363. PMID: 28345958.
      View in: PubMed
    22. Radder JE, Zhang Y, Gregory AD, Yu S, Kelly NJ, Leader JK, Kaminski N, Sciurba FC, Shapiro SD. Extreme Trait Whole-Genome Sequencing Identifies PTPRO as a Novel Candidate Gene in Emphysema with Severe Airflow Obstruction. Am J Respir Crit Care Med. 2017 07 15; 196(2):159-171. PMID: 28199135.
      View in: PubMed
    23. Shapiro SD. Update: healthcare reform - it's getting personal. Per Med. 2017 07; 14(4):281-283. PMID: 29749829.
      View in: PubMed
    24. Kelly NJ, Radder JE, Baust JJ, Burton CL, Lai YC, Potoka KC, Agostini BA, Wood JP, Bachman TN, Vanderpool RR, Dandachi N, Leme AS, Gregory AD, Morris A, Mora AL, Gladwin MT, Shapiro SD. Mouse Genome-Wide Association Study of Preclinical Group II Pulmonary Hypertension Identifies Epidermal Growth Factor Receptor. Am J Respir Cell Mol Biol. 2017 04; 56(4):488-496. PMID: 28085498.
      View in: PubMed
    25. Meng Q, Lai YC, Kelly NJ, Bueno M, Baust JJ, Bachman TN, Goncharov D, Vanderpool RR, Radder JE, Hu J, Goncharova E, Morris AM, Mora AL, Shapiro SD, Gladwin MT. Development of a Mouse Model of Metabolic Syndrome, Pulmonary Hypertension, and Heart Failure with Preserved Ejection Fraction. Am J Respir Cell Mol Biol. 2017 04; 56(4):497-505. PMID: 28118022.
      View in: PubMed
    26. Shapiro SD. Refining Lung Cancer Screening Criteria in the Era of Value-Based Medicine. PLoS Med. 2017 02; 14(2):e1002226. PMID: 28170392.
      View in: PubMed
    27. Shapiro SD, Kaynar AM. Electronic cigarettes: the lesser of two evils, but how much less? Thorax. 2016 12; 71(12):1080-1081. PMID: 28441136.
      View in: PubMed
    28. Kelly NJ, Dandachi N, Goncharov DA, Pena AZ, Radder JE, Gregory AD, Lai YC, Leme AS, Gladwin MT, Goncharova EA, St Croix CM, Shapiro SD. Automated Measurement of Blood Vessels in Tissues from Microscopy Images. Curr Protoc Cytom. 2016 10 10; 78:12.44.1-12.44.13. PMID: 27723088.
      View in: PubMed
    29. Kudryashova TV, Goncharov DA, Pena A, Kelly N, Vanderpool R, Baust J, Kobir A, Shufesky W, Mora AL, Morelli AE, Zhao J, Ihida-Stansbury K, Chang B, DeLisser H, Tuder RM, Kawut SM, Silljé HH, Shapiro S, Zhao Y, Goncharova EA. HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 Oct 01; 194(7):866-877. PMID: 27119551.
      View in: PubMed
    30. Shapiro SD. Transformational Healthcare Models: Medical and Specialty Medical Homes. Inflamm Bowel Dis. 2016 08; 22(8):1984-5. PMID: 27416046.
      View in: PubMed
    31. Kaynar AM, Bakalov V, Laverde SM, Cambriel AI, Lee BH, Towheed A, Gregory AD, Webb SA, Palladino MJ, Bozza FA, Shapiro SD, Angus DC. Cost of surviving sepsis: a novel model of recovery from sepsis in Drosophila melanogaster. Intensive Care Med Exp. 2016 Dec; 4(1):4. PMID: 26791145.
      View in: PubMed
    32. Hidvegi T, Stolz DB, Alcorn JF, Yousem SA, Wang J, Leme AS, Houghton AM, Hale P, Ewing M, Cai H, Garchar EA, Pastore N, Annunziata P, Kaminski N, Pilewski J, Shapiro SD, Pak SC, Silverman GA, Brunetti-Pierri N, Perlmutter DH. Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy. J Biol Chem. 2015 Dec 11; 290(50):29742-57. PMID: 26494620.
      View in: PubMed
    33. Shapiro SD, Karceski S. Mindfulness therapy and seizures. Neurology. 2015 Sep 29; 85(13):e101-3. PMID: 26416804.
      View in: PubMed
    34. Qu Z, Sun F, Zhou J, Li L, Shapiro SD, Xiao G. Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer. Cancer Res. 2015 Aug 15; 75(16):3209-15. PMID: 26122841.
      View in: PubMed
    35. Solleti SK, Simon DM, Srisuma S, Arikan MC, Bhattacharya S, Rangasamy T, Bijli KM, Rahman A, Crossno JT, Shapiro SD, Mariani TJ. Airway epithelial cell PPAR? modulates cigarette smoke-induced chemokine expression and emphysema susceptibility in mice. . 2015 Aug 01; 309(3):L293-304. PMID: 26024894.
      View in: PubMed
    36. Sambamurthy N, Leme AS, Oury TD, Shapiro SD. The receptor for advanced glycation end products (RAGE) contributes to the progression of emphysema in mice. PLoS One. 2015; 10(3):e0118979. PMID: 25781626.
      View in: PubMed
    37. Tsuji T, Kelly NJ, Takahashi S, Leme AS, Houghton AM, Shapiro SD. Macrophage elastase suppresses white adipose tissue expansion with cigarette smoking. Am J Respir Cell Mol Biol. 2014 Dec; 51(6):822-9. PMID: 24914890.
      View in: PubMed
    38. Zhou J, Qu Z, Yan S, Sun F, Whitsett JA, Shapiro SD, Xiao G. Differential roles of STAT3 in the initiation and growth of lung cancer. Oncogene. 2015 Jul; 34(29):3804-3814. PMID: 25284582.
      View in: PubMed
    39. Kaynar AM, Yende S, Zhu L, Frederick DR, Chambers R, Burton CL, Carter M, Stolz DB, Agostini B, Gregory AD, Nagarajan S, Shapiro SD, Angus DC. Effects of intra-abdominal sepsis on atherosclerosis in mice. Crit Care. 2014 Sep 03; 18(5):469. PMID: 25182529.
      View in: PubMed
    40. Radder JE, Shapiro SD, Berndt A. Personalized medicine for chronic, complex diseases: chronic obstructive pulmonary disease as an example. Per Med. 2014 Sep; 11(7):669-679. PMID: 29764057.
      View in: PubMed
    41. Dandachi NG, Shapiro SD. A protean protease: MMP-12 fights viruses as a protease and a transcription factor. Nat Med. 2014 May; 20(5):470-2. PMID: 24804752.
      View in: PubMed
    42. Adler KB, Shapiro SD, Holtzman MJ, McDonald JA. The Red journal at 25 years. Looking back and looking ahead. Am J Respir Cell Mol Biol. 2014 May; 50(5):839-40. PMID: 24783952.
      View in: PubMed
    43. Kelly NJ, Shapiro SD. PPAR? in emphysema: blunts the damage and triggers repair? J Clin Invest. 2014 Mar; 124(3):978-80. PMID: 24569365.
      View in: PubMed
    44. Shapiro SD, Chin CH, Kirkness JP, McGinley BM, Patil SP, Polotsky VY, Biselli PJ, Smith PL, Schneider H, Schwartz AR. Leptin and the control of pharyngeal patency during sleep in severe obesity. J Appl Physiol (1985). 2014 May 15; 116(10):1334-41. PMID: 24557793.
      View in: PubMed
    45. Kaynar AM, Gregory AD, Shapiro SD, Angus DC. Authors' response. Crit Care. 2014; 18(6):645. PMID: 26376498.
      View in: PubMed
    46. Nasto LA, Ngo K, Leme AS, Robinson AR, Dong Q, Roughley P, Usas A, Sowa GA, Pola E, Kang J, Niedernhofer LJ, Shapiro S, Vo NV. Investigating the role of DNA damage in tobacco smoking-induced spine degeneration. Spine J. 2014 Mar 01; 14(3):416-23. PMID: 24211096.
      View in: PubMed
    47. Herazo-Maya JD, Noth I, Duncan SR, Kim S, Ma SF, Tseng GC, Feingold E, Juan-Guardela BM, Richards TJ, Lussier Y, Huang Y, Vij R, Lindell KO, Xue J, Gibson KF, Shapiro SD, Garcia JG, Kaminski N. Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosis. Sci Transl Med. 2013 Oct 02; 5(205):205ra136. PMID: 24089408.
      View in: PubMed
    48. Fanjul-Fernández M, Folgueras AR, Fueyo A, Balbín M, Suárez MF, Fernández-García MS, Shapiro SD, Freije JMP, López-Otín C. Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses. J Biol Chem. 2013 May 17; 288(20):14647-14656. PMID: 23548910.
      View in: PubMed
    49. Himes BE, Sheppard K, Berndt A, Leme AS, Myers RA, Gignoux CR, Levin AM, Gauderman WJ, Yang JJ, Mathias RA, Romieu I, Torgerson DG, Roth LA, Huntsman S, Eng C, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF, Zeiger RS, Strunk RC, Martinez FD, Boushey H, Chinchilli VM, Israel E, Mauger D, Koppelman GH, Postma DS, Nieuwenhuis MA, Vonk JM, Lima JJ, Irvin CG, Peters SP, Kubo M, Tamari M, Nakamura Y, Litonjua AA, Tantisira KG, Raby BA, Bleecker ER, Meyers DA, London SJ, Barnes KC, Gilliland FD, Williams LK, Burchard EG, Nicolae DL, Ober C, DeMeo DL, Silverman EK, Paigen B, Churchill G, Shapiro SD, Weiss ST. Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One. 2013; 8(2):e56179. PMID: 23457522.
      View in: PubMed
    50. McAuliffe PF, Danoff S, Shapiro SD, Davidson NE. Treatment for breast cancer: is time really of the essence? J Natl Cancer Inst. 2013 Jan 16; 105(2):80-2. PMID: 23264682.
      View in: PubMed
    51. Kenche H, Baty CJ, Vedagiri K, Shapiro SD, Blumental-Perry A. Cigarette smoking affects oxidative protein folding in endoplasmic reticulum by modifying protein disulfide isomerase. FASEB J. 2013 Mar; 27(3):965-77. PMID: 23169770.
      View in: PubMed
    52. Berndt A, Leme AS, Shapiro SD. Emerging genetics of COPD. EMBO Mol Med. 2012 Nov; 4(11):1144-55. PMID: 23090857.
      View in: PubMed
    53. Shapiro SD, Eros Y, Abrahami Y, Leviav A. Evaluation of safety and efficacy of the TriPollar technology for treatment of wrinkles. Lasers Surg Med. 2012 Aug; 44(6):453-8. PMID: 22806630.
      View in: PubMed
    54. Shapiro SD. Healthcare reform: it is getting personal. Per Med. 2012 Jun; 9(4):405-412. PMID: 29776259.
      View in: PubMed
    55. Peter Y, Sen N, Levantini E, Keller S, Ingenito EP, Ciner A, Sackstein R, Shapiro SD. CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture. J Tissue Eng Regen Med. 2013 Jul; 7(7):572-83. PMID: 22585451.
      View in: PubMed
    56. Shapiro SD. The future of medicine is very personal. Am J Respir Crit Care Med. 2012 May 01; 185(9):903-4. PMID: 22550204.
      View in: PubMed
    57. Wilson DO, Ryan A, Fuhrman C, Schuchert M, Shapiro S, Siegfried JM, Weissfeld J. Doubling times and CT screen–detected lung cancers in the Pittsburgh Lung Screening Study. Am J Respir Crit Care Med. 2012 Jan 01; 185(1):85-9. PMID: 21997335.
      View in: PubMed
    58. Shapiro SD. Merging personalized medicine and biology of aging in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011 Oct 15; 184(8):864-6. PMID: 22003144.
      View in: PubMed
    59. Lin L, Betsuyaku T, Heimbach L, Li N, Rubenstein D, Shapiro SD, An L, Giudice GJ, Diaz LA, Senior RM, Liu Z. Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid. Matrix Biol. 2012 Jan; 31(1):38-44. PMID: 21979170.
      View in: PubMed
    60. England KA, Price AP, Tram KV, Shapiro SD, Blazar BR, Panoskaltsis-Mortari A. Evidence for early fibrosis and increased airway resistance in bone marrow transplant recipient mice deficient in MMP12. . 2011 Oct; 301(4):L519-26. PMID: 21784967.
      View in: PubMed
    61. Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA, Kiley J, Gail D, Hoshizaki D. Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. Proc Am Thorac Soc. 2011 Jun; 8(3):215-22. PMID: 21653526.
      View in: PubMed
    62. Chen K, Pociask DA, McAleer JP, Chan YR, Alcorn JF, Kreindler JL, Keyser MR, Shapiro SD, Houghton AM, Kolls JK, Zheng M. IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS One. 2011; 6(5):e20333. PMID: 21647421.
      View in: PubMed
    63. Bhattacharya S, Tyagi S, Srisuma S, Demeo DL, Shapiro SD, Bueno R, Silverman EK, Reilly JJ, Mariani TJ. Peripheral blood gene expression profiles in COPD subjects. J Clin Bioinforma. 2011 Apr 24; 1(1):12. PMID: 21884629.
      View in: PubMed
    64. Brown RH, Kaczka DW, Fallano K, Shapiro S, Mitzner W. Individual canine airway response variability to a deep inspiration. Clin Med Insights Circ Respir Pulm Med. 2011 Feb 14; 5:7-15. PMID: 21487453.
      View in: PubMed
    65. Xiong Z, Leme AS, Ray P, Shapiro SD, Lee JS. CX3CR1+ lung mononuclear phagocytes spatially confined to the interstitium produce TNF-a and IL-6 and promote cigarette smoke-induced emphysema. J Immunol. 2011 Mar 01; 186(5):3206-14. PMID: 21278339.
      View in: PubMed
    66. Wan ES, DeMeo DL, Hersh CP, Shapiro SD, Rosiello RA, Sama SR, Fuhlbrigge AL, Foreman MG, Silverman EK. Clinical predictors of frequent exacerbations in subjects with severe chronic obstructive pulmonary disease (COPD). Respir Med. 2011 Apr; 105(4):588-94. PMID: 21145719.
      View in: PubMed
    67. Berndt A, Leme AS, Williams LK, Von Smith R, Savage HS, Stearns TM, Tsaih SW, Shapiro SD, Peters LL, Paigen B, Svenson KL. Comparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice. Physiol Genomics. 2011 Jan 07; 43(1):1-11. PMID: 20823217.
      View in: PubMed
    68. Kaynar AM, Shapiro SD. NET loss of air in cystic fibrosis. Nat Med. 2010 Sep; 16(9):967-9. PMID: 20823877.
      View in: PubMed
    69. Minematsu N, Blumental-Perry A, Shapiro SD. Cigarette smoke inhibits engulfment of apoptotic cells by macrophages through inhibition of actin rearrangement. Am J Respir Cell Mol Biol. 2011 Apr; 44(4):474-82. PMID: 20525804.
      View in: PubMed
    70. Yoshida T, Mett I, Bhunia AK, Bowman J, Perez M, Zhang L, Gandjeva A, Zhen L, Chukwueke U, Mao T, Richter A, Brown E, Ashush H, Notkin N, Gelfand A, Thimmulappa RK, Rangasamy T, Sussan T, Cosgrove G, Mouded M, Shapiro SD, Petrache I, Biswal S, Feinstein E, Tuder RM. Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nat Med. 2010 Jul; 16(7):767-73. PMID: 20473305.
      View in: PubMed
    71. Foreman MG, Kong X, DeMeo DL, Pillai SG, Hersh CP, Bakke P, Gulsvik A, Lomas DA, Litonjua AA, Shapiro SD, Tal-Singer R, Silverman EK. Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):316-22. PMID: 20448057.
      View in: PubMed
    72. Ramsgaard L, Englert JM, Tobolewski J, Tomai L, Fattman CL, Leme AS, Kaynar AM, Shapiro SD, Enghild JJ, Oury TD. The role of the receptor for advanced glycation end-products in a murine model of silicosis. PLoS One. 2010 Mar 19; 5(3):e9604. PMID: 20333255.
      View in: PubMed
    73. Leme AS, Berndt A, Williams LK, Tsaih SW, Szatkiewicz JP, Verdugo R, Paigen B, Shapiro SD. A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci. Mol Genet Genomics. 2010 Apr; 283(4):317-26. PMID: 20143096.
      View in: PubMed
    74. Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE, Metz HE, Stolz DB, Land SR, Marconcini LA, Kliment CR, Jenkins KM, Beaulieu KA, Mouded M, Frank SJ, Wong KK, Shapiro SD. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat Med. 2010 Feb; 16(2):219-23. PMID: 20081861.
      View in: PubMed
    75. Hunninghake GM, Cho MH, Tesfaigzi Y, Soto-Quiros ME, Avila L, Lasky-Su J, Stidley C, Melén E, Söderhäll C, Hallberg J, Kull I, Kere J, Svartengren M, Pershagen G, Wickman M, Lange C, Demeo DL, Hersh CP, Klanderman BJ, Raby BA, Sparrow D, Shapiro SD, Silverman EK, Litonjua AA, Weiss ST, Celedón JC. MMP12, lung function, and COPD in high-risk populations. N Engl J Med. 2009 Dec 31; 361(27):2599-608. PMID: 20018959.
      View in: PubMed
    76. Cackowski FC, Anderson JL, Patrene KD, Choksi RJ, Shapiro SD, Windle JJ, Blair HC, Roodman GD. Osteoclasts are important for bone angiogenesis. Blood. 2010 Jan 07; 115(1):140-9. PMID: 19887675.
      View in: PubMed
    77. Khatwa UA, Kleibrink BE, Shapiro SD, Subramaniam M. MMP-8 promotes polymorphonuclear cell migration through collagen barriers in obliterative bronchiolitis. J Leukoc Biol. 2010 Jan; 87(1):69-77. PMID: 19801498.
      View in: PubMed
    78. DeMeo DL, Mariani T, Bhattacharya S, Srisuma S, Lange C, Litonjua A, Bueno R, Pillai SG, Lomas DA, Sparrow D, Shapiro SD, Criner GJ, Kim HP, Chen Z, Choi AM, Reilly J, Silverman EK. Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet. 2009 Oct; 85(4):493-502. PMID: 19800047.
      View in: PubMed
    79. Houghton AM, Hartzell WO, Robbins CS, Gomis-Rüth FX, Shapiro SD. Macrophage elastase kills bacteria within murine macrophages. Nature. 2009 Jul 30; 460(7255):637-41. PMID: 19536155.
      View in: PubMed
    80. Peter Y, Comellas A, Levantini E, Ingenito EP, Shapiro SD. Epidermal growth factor receptor and claudin-2 participate in A549 permeability and remodeling: implications for non-small cell lung cancer tumor colonization. Mol Carcinog. 2009 Jun; 48(6):488-97. PMID: 18942115.
      View in: PubMed
    81. Punturieri A, Szabo E, Croxton TL, Shapiro SD, Dubinett SM. Lung cancer and chronic obstructive pulmonary disease: needs and opportunities for integrated research. J Natl Cancer Inst. 2009 Apr 15; 101(8):554-9. PMID: 19351920.
      View in: PubMed
    82. Mouded M, Egea EE, Brown MJ, Hanlon SM, Houghton AM, Tsai LW, Ingenito EP, Shapiro SD. Epithelial cell apoptosis causes acute lung injury masquerading as emphysema. Am J Respir Cell Mol Biol. 2009 Oct; 41(4):407-14. PMID: 19188661.
      View in: PubMed
    83. Volonte D, Kahkonen B, Shapiro S, Di Y, Galbiati F. Caveolin-1 expression is required for the development of pulmonary emphysema through activation of the ATM-p53-p21 pathway. J Biol Chem. 2009 Feb 27; 284(9):5462-6. PMID: 19103597.
      View in: PubMed
    84. Abraham E, Adler KB, Shapiro SD, Leff AR. The ATS journals' policy on image manipulation. Proc Am Thorac Soc. 2008 Dec 15; 5(9):869. PMID: 19056709.
      View in: PubMed
    85. Nakanishi Y, Kobayashi D, Asano Y, Sakurai T, Kashimura M, Okuyama S, Yoneda Y, Shapiro SD, Takayama K. Clarithromycin prevents smoke-induced emphysema in mice. Am J Respir Crit Care Med. 2009 Feb 15; 179(4):271-8. PMID: 19060231.
      View in: PubMed
    86. Abraham E, Adler KB, Shapiro SD, Leff AR. The ATS Journals' policy on image manipulation. Am J Respir Cell Mol Biol. 2008 Nov; 39(5):499. PMID: 18927351.
      View in: PubMed
    87. Bhattacharya S, Srisuma S, Demeo DL, Shapiro SD, Bueno R, Silverman EK, Reilly JJ, Mariani TJ. Molecular biomarkers for quantitative and discrete COPD phenotypes. Am J Respir Cell Mol Biol. 2009 Mar; 40(3):359-67. PMID: 18849563.
      View in: PubMed
    88. Houghton AM, Mouded M, Shapiro SD. Common origins of lung cancer and COPD. Nat Med. 2008 Oct; 14(10):1023-4. PMID: 18841139.
      View in: PubMed
    89. Shapiro SD. Lung biology research 2008: revolution in the midst of a gathering storm. Am J Respir Cell Mol Biol. 2008 Oct; 39(4):i-ii. PMID: 18787179.
      View in: PubMed
    90. Shapiro SD. Retraction: involvement of discoidin domain receptor 1 in the deterioration of pulmonary sarcoidosis. Am J Respir Cell Mol Biol. 2008 Sep; 39(3):380. PMID: 18695263.
      View in: PubMed
    91. Shapiro SD. Retraction: stromal-derived factor-1alpha/CXCL12-CXCR 4 axis is involved in the dissemination of NSCLC cells into pleural space. Am J Respir Cell Mol Biol. 2008 Sep; 39(3):380. PMID: 18695264.
      View in: PubMed
    92. Brown RH, Irvin CG, Allen GB, Shapiro SD, Martin WJ, Kolb MR, Hyde DM, Nieman GF, Cody DD, Ishii M, Kadlecek SJ, Driehuys B, Rizi RR, Wu AM, Weber WA, Stout DB. An official ATS conference proceedings: advances in small-animal imaging application to lung pathophysiology. Proc Am Thorac Soc. 2008 Jul 15; 5(5):591-600. PMID: 18625751.
      View in: PubMed
    93. Wilson DO, Weissfeld JL, Balkan A, Schragin JG, Fuhrman CR, Fisher SN, Wilson J, Leader JK, Siegfried JM, Shapiro SD, Sciurba FC. Association of radiographic emphysema and airflow obstruction with lung cancer. Am J Respir Crit Care Med. 2008 Oct 01; 178(7):738-44. PMID: 18565949.
      View in: PubMed
    94. Robbins CS, Franco F, Mouded M, Cernadas M, Shapiro SD. Cigarette smoke exposure impairs dendritic cell maturation and T cell proliferation in thoracic lymph nodes of mice. J Immunol. 2008 May 15; 180(10):6623-8. PMID: 18453581.
      View in: PubMed
    95. Kaynar AM, Houghton AM, Lum EH, Pitt BR, Shapiro SD. Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury. Am J Respir Cell Mol Biol. 2008 Jul; 39(1):53-60. PMID: 18276796.
      View in: PubMed
    96. Shapiro SD. The use of transgenic mice for modeling airways disease. Pulm Pharmacol Ther. 2008 Oct; 21(5):699-701. PMID: 18407535.
      View in: PubMed
    97. Hirakawa H, Pierce RA, Bingol-Karakoc G, Karaaslan C, Weng M, Shi GP, Saad A, Weber E, Mariani TJ, Starcher B, Shapiro SD, Cataltepe S. Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury. Am J Respir Crit Care Med. 2007 Oct 15; 176(8):778-85. PMID: 17673697.
      View in: PubMed
    98. Minematsu N, Shapiro SD. To live and die in the LA (lung airway): mode of neutrophil death and progression of chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):129-30. PMID: 17634347.
      View in: PubMed
    99. Maeno T, Houghton AM, Quintero PA, Grumelli S, Owen CA, Shapiro SD. CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J Immunol. 2007 Jun 15; 178(12):8090-6. PMID: 17548647.
      View in: PubMed
    100. Arredouani MS, Franco F, Imrich A, Fedulov A, Lu X, Perkins D, Soininen R, Tryggvason K, Shapiro SD, Kobzik L. Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation. J Immunol. 2007 May 01; 178(9):5912-20. PMID: 17442975.
      View in: PubMed
    101. Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA. Genomics and proteomics of lung disease: conference summary. . 2007 Jul; 293(1):L45-51. PMID: 17468134.
      View in: PubMed
    102. Matute-Bello G, Wurfel MM, Lee JS, Park DR, Frevert CW, Madtes DK, Shapiro SD, Martin TR. Essential role of MMP-12 in Fas-induced lung fibrosis. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):210-21. PMID: 17446527.
      View in: PubMed
    103. Kreindler JL, Shapiro SD. Lung turns to AA (adenosine analogues) to dry out. Nat Med. 2007 Apr; 13(4):406-8. PMID: 17415371.
      View in: PubMed
    104. Gutiérrez-Fernández A, Inada M, Balbín M, Fueyo A, Pitiot AS, Astudillo A, Hirose K, Hirata M, Shapiro SD, Noël A, Werb Z, Krane SM, López-Otín C, Puente XS. Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). FASEB J. 2007 Aug; 21(10):2580-91. PMID: 17392479.
      View in: PubMed
    105. Chua F, Dunsmore SE, Clingen PH, Mutsaers SE, Shapiro SD, Segal AW, Roes J, Laurent GJ. Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis. Am J Pathol. 2007 Jan; 170(1):65-74. PMID: 17200183.
      View in: PubMed
    106. Shapiro SD. Animal models of asthma: Pro: Allergic avoidance of animal (model[s]) is not an option. Am J Respir Crit Care Med. 2006 Dec 01; 174(11):1171-3. PMID: 17110653.
      View in: PubMed
    107. Xu J, Tian J, Grumelli SM, Haley KJ, Shapiro SD. Stage-specific effects of cAMP signaling during distal lung epithelial development. J Biol Chem. 2006 Dec 15; 281(50):38894-904. PMID: 17018522.
      View in: PubMed
    108. Zhao M, Trimbeger ME, Li N, Diaz LA, Shapiro SD, Liu Z. Role of FcRs in animal model of autoimmune bullous pemphigoid. J Immunol. 2006 Sep 01; 177(5):3398-405. PMID: 16920981.
      View in: PubMed
    109. Simon DM, Arikan MC, Srisuma S, Bhattacharya S, Andalcio T, Shapiro SD, Mariani TJ. Epithelial cell PPARgamma is an endogenous regulator of normal lung maturation and maintenance. Proc Am Thorac Soc. 2006 Aug; 3(6):510-1. PMID: 16921131.
      View in: PubMed
    110. DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celedón J, Reilly J, Chapman HA, Sparrow D, Spira A, Beane J, Pinto-Plata V, Speizer FE, Shapiro S, Weiss ST, Silverman EK. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):502. PMID: 16921128.
      View in: PubMed
    111. Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity. 2006 Aug; 25(2):271-83. PMID: 16872848.
      View in: PubMed
    112. Houghton AM, Grisolano JL, Baumann ML, Kobayashi DK, Hautamaki RD, Nehring LC, Cornelius LA, Shapiro SD. Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases. Cancer Res. 2006 Jun 15; 66(12):6149-55. PMID: 16778188.
      View in: PubMed
    113. Atkinson JJ, Shapiro SD. Neutrophil-mediated eosinophil transmigration: parting the Red Sea or leaving bread crumbs. Am J Respir Cell Mol Biol. 2006 Jun; 34(6):645-6. PMID: 16707628.
      View in: PubMed
    114. Pemberton PA, Kobayashi D, Wilk BJ, Henstrand JM, Shapiro SD, Barr PJ. Inhaled recombinant alpha 1-antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse. COPD. 2006 Jun; 3(2):101-8. PMID: 17175673.
      View in: PubMed
    115. Simon DM, Arikan MC, Srisuma S, Bhattacharya S, Tsai LW, Ingenito EP, Gonzalez F, Shapiro SD, Mariani TJ. Epithelial cell PPAR[gamma] contributes to normal lung maturation. FASEB J. 2006 Jul; 20(9):1507-9. PMID: 16720732.
      View in: PubMed
    116. Stripp BR, Shapiro SD. Stem cells in lung disease, repair, and the potential for therapeutic interventions: State-of-the-art and future challenges. Am J Respir Cell Mol Biol. 2006 May; 34(5):517-18. PMID: 16618784.
      View in: PubMed
    117. Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay MA. Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. Am J Respir Cell Mol Biol. 2006 May; 34(5):523-6. PMID: 16618787.
      View in: PubMed
    118. Zhang L, Ikegami M, Korfhagen TR, McCormack FX, Yoshida M, Senior RM, Shipley JM, Shapiro SD, Whitsett JA. Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis. . 2006 Aug; 291(2):L181-90. PMID: 16500946.
      View in: PubMed
    119. Houghton AM, Quintero PA, Perkins DL, Kobayashi DK, Kelley DG, Marconcini LA, Mecham RP, Senior RM, Shapiro SD. Elastin fragments drive disease progression in a murine model of emphysema. J Clin Invest. 2006 Mar; 116(3):753-9. PMID: 16470245.
      View in: PubMed
    120. Demeo DL, Mariani TJ, Lange C, Srisuma S, Litonjua AA, Celedon JC, Lake SL, Reilly JJ, Chapman HA, Mecham BH, Haley KJ, Sylvia JS, Sparrow D, Spira AE, Beane J, Pinto-Plata V, Speizer FE, Shapiro SD, Weiss ST, Silverman EK. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet. 2006 Feb; 78(2):253-64. PMID: 16358219.
      View in: PubMed
    121. Mahadeva R, Shapiro SD. Animal models of pulmonary emphysema. Curr Drug Targets Inflamm Allergy. 2005 Dec; 4(6):665-73. PMID: 17305522.
      View in: PubMed
    122. Wang X, Inoue S, Gu J, Miyoshi E, Noda K, Li W, Mizuno-Horikawa Y, Nakano M, Asahi M, Takahashi M, Uozumi N, Ihara S, Lee SH, Ikeda Y, Yamaguchi Y, Aze Y, Tomiyama Y, Fujii J, Suzuki K, Kondo A, Shapiro SD, Lopez-Otin C, Kuwaki T, Okabe M, Honke K, Taniguchi N. Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. Proc Natl Acad Sci U S A. 2005 Nov 01; 102(44):15791-6. PMID: 16236725.
      View in: PubMed
    123. Pemberton PA, Cantwell JS, Kim KM, Sundin DJ, Kobayashi D, Fink JB, Shapiro SD, Barr PJ. An inhaled matrix metalloprotease inhibitor prevents cigarette smoke-induced emphysema in the mouse. COPD. 2005 Sep; 2(3):303-10. PMID: 17146995.
      View in: PubMed
    124. Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noël A, Cataldo DD. Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J Immunol. 2005 Aug 15; 175(4):2589-97. PMID: 16081833.
      View in: PubMed
    125. Weaver A, Goncalves da Silva A, Nuttall RK, Edwards DR, Shapiro SD, Rivest S, Yong VW. An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization. FASEB J. 2005 Oct; 19(12):1668-70. PMID: 16081501.
      View in: PubMed
    126. Arikan MC, Shapiro SD, Mariani TJ. Induction of macrophage elastase (MMP-12) gene expression by statins. J Cell Physiol. 2005 Jul; 204(1):139-45. PMID: 15605420.
      View in: PubMed
    127. Kassim SY, Fu X, Liles WC, Shapiro SD, Parks WC, Heinecke JW. NADPH oxidase restrains the matrix metalloproteinase activity of macrophages. J Biol Chem. 2005 Aug 26; 280(34):30201-5. PMID: 15983040.
      View in: PubMed
    128. Raptis SZ, Shapiro SD, Simmons PM, Cheng AM, Pham CT. Serine protease cathepsin G regulates adhesion-dependent neutrophil effector functions by modulating integrin clustering. Immunity. 2005 Jun; 22(6):679-91. PMID: 15963783.
      View in: PubMed
    129. Shapiro SD. COPD unwound. N Engl J Med. 2005 May 12; 352(19):2016-9. PMID: 15888704.
      View in: PubMed
    130. Shapiro SD, Ingenito EP. The pathogenesis of chronic obstructive pulmonary disease: advances in the past 100 years. Am J Respir Cell Mol Biol. 2005 May; 32(5):367-72. PMID: 15837726.
      View in: PubMed
    131. Senft AP, Korfhagen TR, Whitsett JA, Shapiro SD, LeVine AM. Surfactant protein-D regulates soluble CD14 through matrix metalloproteinase-12. J Immunol. 2005 Apr 15; 174(8):4953-9. PMID: 15814723.
      View in: PubMed
    132. Longo GM, Buda SJ, Fiotta N, Xiong W, Griener T, Shapiro S, Baxter BT. MMP-12 has a role in abdominal aortic aneurysms in mice. Surgery. 2005 Apr; 137(4):457-62. PMID: 15800495.
      View in: PubMed
    133. Abraham E, Shapiro SD, Leff AR. The NIH Public Access Policy and ATS journals. Am J Respir Crit Care Med. 2005 Apr 01; 171(7):671-2. PMID: 15790862.
      View in: PubMed
    134. Gidday JM, Gasche YG, Copin JC, Shah AR, Perez RS, Shapiro SD, Chan PH, Park TS. Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia. . 2005 Aug; 289(2):H558-68. PMID: 15764676.
      View in: PubMed
    135. Nénan S, Planquois JM, Berna P, De Mendez I, Hitier S, Shapiro SD, Boichot E, Lagente V, Bertrand CP. Analysis of the inflammatory response induced by rhMMP-12 catalytic domain instilled in mouse airways. Int Immunopharmacol. 2005 Mar; 5(3):511-24. PMID: 15683848.
      View in: PubMed
    136. Mahadeva R, Atkinson C, Li Z, Stewart S, Janciauskiene S, Kelley DG, Parmar J, Pitman R, Shapiro SD, Lomas DA. Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo. Am J Pathol. 2005 Feb; 166(2):377-86. PMID: 15681822.
      View in: PubMed
    137. Xu J, Tian J, Shapiro SD. Normal lung development in RAIG1-deficient mice despite unique lung epithelium-specific expression. Am J Respir Cell Mol Biol. 2005 May; 32(5):381-7. PMID: 15677768.
      View in: PubMed
    138. Abraham E, Shapiro SD, Leff AR. The NIH Public Access Policy and ATS journals. Proc Am Thorac Soc. 2005; 2(1):1-2. PMID: 16113460.
      View in: PubMed
    139. Leff AR, Shapiro SD, Abraham E. The unintended consequences of noble intentions to inform. Proc Am Thorac Soc. 2005; 2(1):2-3. PMID: 16113461.
      View in: PubMed
    140. Warner RL, Lukacs NW, Shapiro SD, Bhagarvathula N, Nerusu KC, Varani J, Johnson KJ. Role of metalloelastase in a model of allergic lung responses induced by cockroach allergen. Am J Pathol. 2004 Dec; 165(6):1921-30. PMID: 15579436.
      View in: PubMed
    141. Buckley C, Wyble CW, Borhani M, Ennis TL, Kobayashi DK, Curci JA, Shapiro SD, Thompson RW. Accelerated enlargement of experimental abdominal aortic aneurysms in a mouse model of chronic cigarette smoke exposure. J Am Coll Surg. 2004 Dec; 199(6):896-903. PMID: 15555973.
      View in: PubMed
    142. Sabeh F, Ota I, Holmbeck K, Birkedal-Hansen H, Soloway P, Balbin M, Lopez-Otin C, Shapiro S, Inada M, Krane S, Allen E, Chung D, Weiss SJ. Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. J Cell Biol. 2004 Nov 22; 167(4):769-81. PMID: 15557125.
      View in: PubMed
    143. Shapiro SD. Smoke gets in your cells. Am J Respir Cell Mol Biol. 2004 Nov; 31(5):481-2. PMID: 15494469.
      View in: PubMed
    144. Shapiro SD, Demeo DL, Silverman EK. Smoke and mirrors: Mouse models as a reflection of human chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004 Nov 01; 170(9):929-31. PMID: 15504815.
      View in: PubMed
    145. Owen CA, Hu Z, Lopez-Otin C, Shapiro SD. Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase. J Immunol. 2004 Jun 15; 172(12):7791-803. PMID: 15187163.
      View in: PubMed
    146. Young RE, Thompson RD, Larbi KY, La M, Roberts CE, Shapiro SD, Perretti M, Nourshargh S. Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J Immunol. 2004 Apr 01; 172(7):4493-502. PMID: 15034066.
      View in: PubMed
    147. Riese RJ, Finn PW, Shapiro SD. Influenza and asthma: adding to the respiratory burden. Nat Immunol. 2004 Mar; 5(3):243-4. PMID: 14985710.
      View in: PubMed
    148. Hou P, Troen T, Ovejero MC, Kirkegaard T, Andersen TL, Byrjalsen I, Ferreras M, Sato T, Shapiro SD, Foged NT, Delaissé JM. Matrix metalloproteinase-12 (MMP-12) in osteoclasts: new lesson on the involvement of MMPs in bone resorption. Bone. 2004 Jan; 34(1):37-47. PMID: 14751561.
      View in: PubMed
    149. Dunsmore SE, Shapiro SD. The bone marrow leaves its scar: new concepts in pulmonary fibrosis. J Clin Invest. 2004 Jan; 113(2):180-2. PMID: 14722608.
      View in: PubMed
    150. Shapiro SD, Goldstein NM, Houghton AM, Kobayashi DK, Kelley D, Belaaouaj A. Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol. 2003 Dec; 163(6):2329-35. PMID: 14633606.
      View in: PubMed
    151. Shapiro SD. The post-genomic red journal: charting the path from hope (not hype) to cure. Am J Respir Cell Mol Biol. 2003 Oct; 29(4):425-6. PMID: 14500252.
      View in: PubMed
    152. Balbín M, Fueyo A, Tester AM, Pendás AM, Pitiot AS, Astudillo A, Overall CM, Shapiro SD, López-Otín C. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nat Genet. 2003 Nov; 35(3):252-7. PMID: 14517555.
      View in: PubMed
    153. Filippov S, Caras I, Murray R, Matrisian LM, Chapman HA, Shapiro S, Weiss SJ. Matrilysin-dependent elastolysis by human macrophages. J Exp Med. 2003 Sep 15; 198(6):925-35. PMID: 12963695.
      View in: PubMed
    154. Pouladi MA, Robbins CS, Swirski FK, Cundall M, McKenzie AN, Jordana M, Shapiro SD, Stämpfli MR. Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in mice. Am J Respir Cell Mol Biol. 2004 Jan; 30(1):84-90. PMID: 12842850.
      View in: PubMed
    155. Dollery CM, Owen CA, Sukhova GK, Krettek A, Shapiro SD, Libby P. Neutrophil elastase in human atherosclerotic plaques: production by macrophages. Circulation. 2003 Jun 10; 107(22):2829-36. PMID: 12771009.
      View in: PubMed
    156. Owen CA, Hu Z, Barrick B, Shapiro SD. Inducible expression of tissue inhibitor of metalloproteinases-resistant matrix metalloproteinase-9 on the cell surface of neutrophils. Am J Respir Cell Mol Biol. 2003 Sep; 29(3 Pt 1):283-94. PMID: 12663332.
      View in: PubMed
    157. Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, Glick A, Sheppard D. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature. 2003 Mar 13; 422(6928):169-73. PMID: 12634787.
      View in: PubMed
    158. Pechet TV, de le Morena M, Mendeloff EN, Sweet SC, Shapiro SD, Huddleston CB. Lung transplantation in children following treatment for malignancy. J Heart Lung Transplant. 2003 Feb; 22(2):154-60. PMID: 12581763.
      View in: PubMed
    159. Shapiro SD. Immunology: Mobilizing the army. Nature. 2003 Jan 16; 421(6920):223-4. PMID: 12529625.
      View in: PubMed
    160. Churg A, Wang RD, Tai H, Wang X, Xie C, Dai J, Shapiro SD, Wright JL. Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release. Am J Respir Crit Care Med. 2003 Apr 15; 167(8):1083-9. PMID: 12522030.
      View in: PubMed
    161. Kure T, Chang JH, Kato T, Hernández-Quintela E, Ye H, Lu PC, Matrisian LM, Gatinel D, Shapiro S, Gosheh F, Azar DT, Gosheh F. Corneal neovascularization after excimer keratectomy wounds in matrilysin-deficient mice. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):137-44. PMID: 12506066.
      View in: PubMed
    162. Hornstra IK, Birge S, Starcher B, Bailey AJ, Mecham RP, Shapiro SD. Lysyl oxidase is required for vascular and diaphragmatic development in mice. J Biol Chem. 2003 Apr 18; 278(16):14387-93. PMID: 12473682.
      View in: PubMed
    163. Kerkelä E, Ala-aho R, Klemi P, Grénman S, Shapiro SD, Kähäri VM, Saarialho-Kere U. Metalloelastase (MMP-12) expression by tumour cells in squamous cell carcinoma of the vulva correlates with invasiveness, while that by macrophages predicts better outcome. J Pathol. 2002 Oct; 198(2):258-69. PMID: 12237887.
      View in: PubMed
    164. Shapiro SD, Owen CA. ADAM-33 surfaces as an asthma gene. N Engl J Med. 2002 Sep 19; 347(12):936-8. PMID: 12239266.
      View in: PubMed
    165. Churg A, Zay K, Shay S, Xie C, Shapiro SD, Hendricks R, Wright JL. Acute cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice. Am J Respir Cell Mol Biol. 2002 Sep; 27(3):368-74. PMID: 12204900.
      View in: PubMed
    166. Lanone S, Zheng T, Zhu Z, Liu W, Lee CG, Ma B, Chen Q, Homer RJ, Wang J, Rabach LA, Rabach ME, Shipley JM, Shapiro SD, Senior RM, Elias JA. Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest. 2002 Aug; 110(4):463-74. PMID: 12189240.
      View in: PubMed
    167. Weinrauch Y, Drujan D, Shapiro SD, Weiss J, Zychlinsky A. Neutrophil elastase targets virulence factors of enterobacteria. Nature. 2002 May 02; 417(6884):91-4. PMID: 12018205.
      View in: PubMed
    168. Mariani TJ, Reed JJ, Shapiro SD. Expression profiling of the developing mouse lung: insights into the establishment of the extracellular matrix. Am J Respir Cell Mol Biol. 2002 May; 26(5):541-8. PMID: 11970905.
      View in: PubMed
    169. Allport JR, Lim YC, Shipley JM, Senior RM, Shapiro SD, Matsuyoshi N, Vestweber D, Luscinskas FW. Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro. J Leukoc Biol. 2002 May; 71(5):821-8. PMID: 11994507.
      View in: PubMed
    170. Shapiro SD. Neutrophil elastase: path clearer, pathogen killer, or just pathologic? Am J Respir Cell Mol Biol. 2002 Mar; 26(3):266-8. PMID: 11867332.
      View in: PubMed
    171. Mariani TJ, Shapiro SD. Thomas A. Neff lecture. Application of expression profiling to the developing lung: identification of putative regulatory networks controlling matrix production. Chest. 2002 Mar; 121(3 Suppl):42S-44S. PMID: 11893680.
      View in: PubMed
    172. Mi Y, Shapiro SD, Baenziger JU. Regulation of lutropin circulatory half-life by the mannose/N-acetylgalactosamine-4-SO4 receptor is critical for implantation in vivo. J Clin Invest. 2002 Jan; 109(2):269-76. PMID: 11805139.
      View in: PubMed
    173. Mendeloff EN, Meyers BF, Sundt TM, Guthrie TJ, Sweet SC, de la Morena M, Shapiro S, Balzer DT, Trulock EP, Lynch JP, Pasque MK, Cooper JD, Huddleston CB, Patterson GA. Lung transplantation for pulmonary vascular disease. Ann Thorac Surg. 2002 Jan; 73(1):209-17; discussion 217-9. PMID: 11834012.
      View in: PubMed
    Shapiro's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description