Marc Ivor Chimowitz

TitleAssociate Dean for Faculty Development
InstitutionMedical University of South Carolina
DepartmentNeurology
AddressP.O. Box MSC 805
HOT 501
Harborview Office Tower - 19 Hagood Ave.
Phone843-792-3020
Fax843-792-2484
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    Collapse Overview 
    Collapse overview
    Dr. Marc Chimowitz researches treatments to prevent stroke caused by narrowing of brain arteries. This field of research is especially relevant in South Carolina, which has the nation’s second-highest mortality rate from stroke.

    Stroke is the fourth leading cause of death in the United States. Stenosis, a blockage or narrowing of a brain artery caused by the build up of plaque, accounts for more than 50,000 of the 795,000 strokes that occur annually nationwide. Stenosis is particularly common in African Americans, Hispanics, Asian Americans, and people with diabetes.

    Dr. Chimowitz received funding from the National Institutes of Health for a $28.5 million, 50-center nationwide clinical trial, which he led from the Medical University of South Carolina. The study showed that aggressive medical management alone is superior to aggressive medical management combined with a specific type of brain stent for patients at high risk for stroke. Dr. Chomowitz and the team of investigators published the results from the Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) trial in The New England Journal of Medicine.

    This was one of the largest extramural research grants in South Carolina history. The trial studied the value of using stents to prevent strokes in patients whose brain arteries have hardened and narrowed due to plaque buildup (atherosclerotic stenosis). The findings of this study have the potential to revolutionize stroke care.
    Collapse keywords
    Acute stroke management, Outpatient stroke consultation, Stroke research and clinical trials

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    Collapse studies/trials

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chaturvedi S, Chimowitz M. Silent Myocardial Infarction and Stroke Risk: We Should Be Listening. Neurology. 2021 May 24. PMID: 34031207.
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    2. Romano JG, Prabhakaran S, Nizam A, Feldmann E, Sangha R, Cotsonis G, Campo-Bustillo I, Koch S, Rundek T, Chimowitz MI, Liebeskind DS. Infarct Recurrence in Intracranial Atherosclerosis: Results from the MyRIAD Study. J Stroke Cerebrovasc Dis. 2021 Feb; 30(2):105504. PMID: 33276302.
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    3. Turan TN, Meschia JF, Chimowitz MI, Roldan A, LeMatty T, Luke S, Breathitt L, Eiland R, Foley J, Brott TG. Mitigating the effects of COVID-19 pandemic on controlling vascular risk factors among participants in a carotid stenosis trial. J Stroke Cerebrovasc Dis. 2020 Dec; 29(12):105362. PMID: 33071206.
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    4. Turan TN, Voeks JH, Chimowitz MI, Roldan A, LeMatty T, Haley W, Lopes-Virella M, Chaturvedi S, Jones M, Heck D, Howard G, Lal BK, Meschia JF, Brott TG. Rationale, Design, and Implementation of Intensive Risk Factor Treatment in the CREST2 Trial. Stroke. 2020 10; 51(10):2960-2971. PMID: 32951538.
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    5. Abdul Rahman L, Turan TN, Cotsonis G, Almallouhi E, Holmstedt CA, Chimowitz MI. Dual Antiplatelet Therapy Beyond 90 days in Symptomatic Intracranial Stenosis in the SAMMPRIS Trial. J Stroke Cerebrovasc Dis. 2020 Dec; 29(12):105254. PMID: 32992190.
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    6. Liebeskind DS, Prabhakaran S, Azhar N, Feldmann E, Campo-Bustillo I, Sangha R, Koch S, Rundek T, Ostergren L, Chimowitz MI, Romano JG. Mechanisms of early Recurrence in Intracranial Atherosclerotic Disease (MyRIAD): Rationale and design. J Stroke Cerebrovasc Dis. 2020 Oct; 29(10):105051. PMID: 32912558.
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    7. Broderick JP, Elm JJ, Janis LS, Zhao W, Moy CS, Dillon CR, Chimowitz MI, Sacco RL, Cramer SC, Wolf SL, Johnston KC, Saver JL, Marshall RS, Brown D, Wintermark M, Elkind MSV, Kamel H, Tirschwell DL, Longstreth WT, Chervin RD, Adeoye OM, Barreto AD, Grotta JC, Ramey SL, Lo WD, Feng W, Schlaug G, Sheth KN, Selim M, Naidech AM, Lansberg MG, Lazar RM, Albers GW, Griffin JS, Sirline LP, Frasure J, Wright CB, Khatri P. National Institutes of Health StrokeNet During the Time of COVID-19 and Beyond. Stroke. 2020 08; 51(8):2580-2586. PMID: 32716819.
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    8. Harrigan MR, Griffin RL, Deveikis JP, Prattipati V, Chimowitz MI, Jansen JO. New ischemic lesions on brain magnetic resonance imaging in patients with blunt traumatic cerebrovascular injury. J Trauma Acute Care Surg. 2020 06; 88(6):796-802. PMID: 32176175.
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    9. Bonilha H, Hyer M, Krug E, Mauldin M, Edlund B, Martin-Harris B, Halushka P, McGinty J, Sullivan J, Brady K, Ranwala D, Hermayer K, Harvey J, Paranal R, Gough J, Silvestri G, Chimowitz M. An institution-wide faculty mentoring program at an academic health center with 6-year prospective outcome data - ADDENDUM. J Clin Transl Sci. 2020 Mar 31; 4(4):370. PMID: 33244421.
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    10. Almallouhi E, Al Kasab S, Yamada L, Martin RH, Turan TN, Chimowitz MI. Relationship Between Vascular Risk Factors and Location of Intracranial Atherosclerosis in the SAMMPRIS Trial. J Stroke Cerebrovasc Dis. 2020 May; 29(5):104713. PMID: 32089436.
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    11. Bonilha H, Hyer M, Krug E, Mauldin M, Edlund B, Martin-Harris B, Halushka P, McGinty J, Sullivan J, Brady K, Ranwala D, Hermayer K, Harvey J, Paranal R, Gough J, Silvestri G, Chimowitz M. An institution-wide faculty mentoring program at an academic health center with 6-year prospective outcome data. J Clin Transl Sci. 2019 Dec; 3(6):308-315. PMID: 31827904.
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    12. Turan TN, Al Kasab S, Smock A, Cotsonis G, Bachman D, Lynn MJ, Nizam A, Derdeyn CP, Fiorella D, Janis S, Lane B, Montgomery J, Chimowitz MI. Impact of Baseline Features and Risk Factor Control on Cognitive Function in the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial. Cerebrovasc Dis. 2019; 47(1-2):24-31. PMID: 30763948.
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    13. Turan TN, Kasab SA, Nizam A, Hannah J, Gordon N, Lynn MJ, Derdeyn CP, Fiorella D, Janis LS, Lane BF, Montgomery J, Chimowitz MI. Type and Duration of Exercise in the SAMMPRIS Trial. Neurologist. 2019 Jan; 24(1):10-12. PMID: 30586027.
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    14. Wabnitz AM, Derdeyn CP, Fiorella DJ, Lynn MJ, Cotsonis GA, Liebeskind DS, Waters MF, Lutsep H, López-Cancio E, Turan TN, Montgomery J, Janis LS, Lane B, Chimowitz MI. Hemodynamic Markers in the Anterior Circulation as Predictors of Recurrent Stroke in Patients With Intracranial Stenosis. Stroke. 2018 Dec 11; STROKEAHA118020840. PMID: 30580705.
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    15. Cassarly C, Martin RH, Chimowitz M, Peña EA, Ramakrishnan V, Palesch YY. Treatment effect on ordinal functional outcome using piecewise multistate Markov model with unobservable baseline: an application to the modified Rankin scale. J Biopharm Stat. 2019; 29(1):82-97. PMID: 29985739.
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    16. Turan TN, Al Kasab S, Nizam A, Lynn MJ, Harrell J, Derdeyn CP, Fiorella D, Janis LS, Lane BF, Montgomery J, Chimowitz MI. Relationship between Risk Factor Control and Compliance with a Lifestyle Modification Program in the Stenting Aggressive Medical Management for Prevention of Recurrent Stroke in Intracranial Stenosis Trial. J Stroke Cerebrovasc Dis. 2018 Mar; 27(3):801-805. PMID: 29169967.
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    17. Nagahama Y, Allan L, Nakagawa D, Zanaty M, Starke RM, Chalouhi N, Jabbour P, Brown RD, Derdeyn CP, Leira EC, Broderick J, Chimowitz M, Torner JC, Hasan D. Dual antiplatelet therapy in aneurysmal subarachnoid hemorrhage: association with reduced risk of clinical vasospasm and delayed cerebral ischemia. J Neurosurg. 2018 09; 129(3):702-710. PMID: 29099296.
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    18. Roberts DR, Albrecht MH, Collins HR, Asemani D, Chatterjee AR, Spampinato MV, Zhu X, Chimowitz MI, Antonucci MU. Effects of Spaceflight on Astronaut Brain Structure as Indicated on MRI. N Engl J Med. 2017 11 02; 377(18):1746-1753. PMID: 29091569.
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    19. Cassarly C, Martin RH, Chimowitz M, Peña EA, Ramakrishnan V, Palesch YY. Comparison of multistate Markov modeling with contemporary outcomes in a reanalysis of the NINDS tissue plasminogen activator for acute ischemic stroke treatment trial. PLoS One. 2017; 12(10):e0187050. PMID: 29073195.
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    20. Wabnitz A, Chimowitz M. Angioplasty, Stenting and Other Potential Treatments of Atherosclerotic Stenosis of the Intracranial Arteries: Past, Present and Future. J Stroke. 2017 Sep; 19(3):271-276. PMID: 29037013.
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    21. Howard VJ, Meschia JF, Lal BK, Turan TN, Roubin GS, Brown RD, Voeks JH, Barrett KM, Demaerschalk BM, Huston J, Lazar RM, Moore WS, Wadley VG, Chaturvedi S, Moy CS, Chimowitz M, Howard G, Brott TG. Carotid revascularization and medical management for asymptomatic carotid stenosis: Protocol of the CREST-2 clinical trials. Int J Stroke. 2017 10; 12(7):770-778. PMID: 28462683.
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    22. Derdeyn CP, Fiorella D, Lynn MJ, Turan TN, Cotsonis GA, Lane BF, Montgomery J, Janis LS, Chimowitz MI. Nonprocedural Symptomatic Infarction and In-Stent Restenosis After Intracranial Angioplasty and Stenting in the SAMMPRIS Trial (Stenting and Aggressive Medical Management for the Prevention of Recurrent Stroke in Intracranial Stenosis). Stroke. 2017 06; 48(6):1501-1506. PMID: 28455321.
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    23. Banerjee C, Chimowitz MI. Stroke Caused by Atherosclerosis of the Major Intracranial Arteries. Circ Res. 2017 Feb 03; 120(3):502-513. PMID: 28154100.
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    24. Al Kasab S, Cassarly C, Le NA, Martin R, Brinley J, Chimowitz MI, Turan TN. Postprandial Clearance of Oxidized Low-Density Lipoprotein in Patients with Stroke Due to Atherosclerosis. J Stroke Cerebrovasc Dis. 2017 Mar; 26(3):488-493. PMID: 28089094.
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    25. Turan TN, Nizam A, Lynn MJ, Egan BM, Le NA, Lopes-Virella MF, Hermayer KL, Harrell J, Derdeyn CP, Fiorella D, Janis LS, Lane B, Montgomery J, Chimowitz MI. Relationship between risk factor control and vascular events in the SAMMPRIS trial. Neurology. 2017 Jan 24; 88(4):379-385. PMID: 28003500.
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    26. Leung TW, Wabnitz AM, Miao Z, Chimowitz MI. Angioplasty and Stenting. Front Neurol Neurosci. 2016; 40:152-163. PMID: 27960179.
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    27. Turan TN, Smock A, Cotsonis G, Bachman D, Al Kasab S, Lynn MJ, Nizham A, Derdeyn CP, Fiorella D, Janis S, Lane B, Montgomery J, Chimowitz MI. Is There Benefit from Stenting on Cognitive Function in Intracranial Atherosclerosis? Cerebrovasc Dis. 2017; 43(1-2):31-35. PMID: 27820930.
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    28. Al Kasab S, Lynn MJ, Turan TN, Derdeyn CP, Fiorella D, Lane BF, Janis LS, Chimowitz MI. Impact of the New American Heart Association/American Stroke Association Definition of Stroke on the Results of the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial. J Stroke Cerebrovasc Dis. 2017 Jan; 26(1):108-115. PMID: 27765556.
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    29. Chaturvedi S, Chimowitz M, Brown RD, Lal BK, Meschia JF. The urgent need for contemporary clinical trials in patients with asymptomatic carotid stenosis. Neurology. 2016 Nov 22; 87(21):2271-2278. PMID: 27683853.
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    30. Cassarly C, Martin RH, Chimowitz M, Peña EA, Ramakrishnan V, Palesch YY. Assessing type I error and power of multistate Markov models for panel data-A simulation study. Commun Stat Simul Comput. 2017; 46(9):7040-7061. PMID: 29225407.
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    31. Al Kasab S, Hess DC, Chimowitz MI. Rationale for ischemic conditioning to prevent stroke in patients with intracranial arterial stenosis. Brain Circ. 2016 Apr-Jun; 2(2):67-71. PMID: 30276275.
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    32. Waters MF, Hoh BL, Lynn MJ, Kwon HM, Turan TN, Derdeyn CP, Fiorella D, Khanna A, Sheehan TO, Lane BF, Janis S, Montgomery J, Chimowitz MI. Factors Associated With Recurrent Ischemic Stroke in the Medical Group of the SAMMPRIS Trial. JAMA Neurol. 2016 Mar; 73(3):308-15. PMID: 26747792.
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    33. Kwon HM, Lynn MJ, Turan TN, Derdeyn CP, Fiorella D, Lane BF, Montgomery J, Janis LS, Rumboldt Z, Chimowitz MI. Frequency, Risk Factors, and Outcome of Coexistent Small Vessel Disease and Intracranial Arterial Stenosis: Results From the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) Trial. JAMA Neurol. 2016 Jan; 73(1):36-42. PMID: 26618534.
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    34. Chiu D, Klucznik RP, Turan TN, Lynn MJ, McCane CD, Katz LB, Nizam A, Derdeyn CP, Fiorella D, Lane BF, Montgomery J, Janis S, Chimowitz MI. Enrollment volume effect on risk factor control and outcomes in the SAMMPRIS trial. Neurology. 2015 Dec 15; 85(24):2090-7. PMID: 26561294.
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    35. Turan TN, LeMatty T, Martin R, Chimowitz MI, Rumboldt Z, Spampinato MV, Stalcup S, Adams RJ, Brown T. Characterization of intracranial atherosclerotic stenosis using high-resolution MRI study--rationale and design. Brain Behav. 2015 Dec; 5(12):e00397. PMID: 26807333.
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    36. Lutsep HL, Lynn MJ, Cotsonis GA, Derdeyn CP, Turan TN, Fiorella D, Janis LS, Lane BF, Montgomery J, Chimowitz MI. Does the Stenting Versus Aggressive Medical Therapy Trial Support Stenting for Subgroups With Intracranial Stenosis? Stroke. 2015 Nov; 46(11):3282-4. PMID: 26382173.
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    37. Chaturvedi S, Turan TN, Lynn MJ, Derdeyn CP, Fiorella D, Janis LS, Chimowitz MI. Do Patient Characteristics Explain the Differences in Outcome Between Medically Treated Patients in SAMMPRIS and WASID? Stroke. 2015 Sep; 46(9):2562-7. PMID: 26251251.
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    38. Turan TN, Chimowitz MI. Yet again no benefit of stenting over medical therapy. Lancet Neurol. 2015 Jun; 14(6):565-6. PMID: 25908091.
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    39. Chimowitz MI, Derdeyn CP. Endovascular therapy for atherosclerotic intracranial arterial stenosis: back to the drawing board. JAMA. 2015 Mar 24-31; 313(12):1219-20. PMID: 25803345.
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    40. Lutsep HL, Barnwell SL, Larsen DT, Lynn MJ, Hong M, Turan TN, Derdeyn CP, Fiorella D, Janis LS, Chimowitz MI. Outcome in patients previously on antithrombotic therapy in the SAMMPRIS trial: subgroup analysis. Stroke. 2015 Mar; 46(3):775-9. PMID: 25593135.
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    41. López-Cancio E, Matheus MG, Romano JG, Liebeskind DS, Prabhakaran S, Turan TN, Cotsonis GA, Lynn MJ, Rumboldt Z, Chimowitz MI. Infarct patterns, collaterals and likely causative mechanisms of stroke in symptomatic intracranial atherosclerosis. Cerebrovasc Dis. 2014; 37(6):417-22. PMID: 25011483.
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    42. Ellis C, Hyacinth HI, Beckett J, Feng W, Chimowitz M, Ovbiagele B, Lackland D, Adams R. Racial/Ethnic differences in poststroke rehabilitation outcomes. Stroke Res Treat. 2014; 2014:950746. PMID: 25028619.
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    43. Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI, Ezekowitz MD, Fang MC, Fisher M, Furie KL, Heck DV, Johnston SC, Kasner SE, Kittner SJ, Mitchell PH, Rich MW, Richardson D, Schwamm LH, Wilson JA. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014 Jul; 45(7):2160-236. PMID: 24788967.
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    44. Chimowitz MI, Caplan LR. Is calcification of intracranial arteries important and how? JAMA Neurol. 2014 Apr; 71(4):401-2. PMID: 24535614.
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    45. Chimowitz MI. Game changer for endovascular treatment of acute ischemic stroke? J Neurointerv Surg. 2014 May; 6(4):252-3. PMID: 24623835.
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    46. Liebeskind DS, Kosinski AS, Lynn MJ, Scalzo F, Fong AK, Fariborz P, Chimowitz MI, Feldmann E. Noninvasive fractional flow on MRA predicts stroke risk of intracranial stenosis. J Neuroimaging. 2015 Jan-Feb; 25(1):87-91. PMID: 24593693.
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    47. Turan TN, Cotsonis G, Lynn MJ, Wooley RH, Swanson S, Williams JE, Stern BJ, Derdeyn CP, Fiorella D, Chimowitz MI. Intracranial stenosis: impact of randomized trials on treatment preferences of US neurologists and neurointerventionists. Cerebrovasc Dis. 2014; 37(3):203-11. PMID: 24557055.
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    48. Derdeyn CP, Fiorella D, Chimowitz MI. In reply: Is there a contribution of anesthesia to the outcome of the SAMMPRIS trial? Neurosurgery. 2014 Feb; 74(2):E235-6. PMID: 24149979.
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    49. Turan TN, Smock A, Chimowitz MI. The challenge of stroke prevention with intracranial arterial stenosis. Curr Cardiol Rep. 2013 Dec; 15(12):422. PMID: 24105641.
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    50. Holmstedt CA, Turan TN, Chimowitz MI. Atherosclerotic intracranial arterial stenosis: risk factors, diagnosis, and treatment. Lancet Neurol. 2013 Nov; 12(11):1106-14. PMID: 24135208.
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    51. Derdeyn CP, Chimowitz MI, Lynn MJ, Fiorella D, Turan TN, Janis LS, Montgomery J, Nizam A, Lane BF, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL, Lynch JR, Zaidat OO, Rumboldt Z, Cloft HJ. Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial. Lancet. 2014 Jan 25; 383(9914):333-41. PMID: 24168957.
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    52. Chimowitz MI. The Feinberg Award Lecture 2013: treatment of intracranial atherosclerosis: learning from the past and planning for the future. Stroke. 2013 Sep; 44(9):2664-9. PMID: 23821232.
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    53. Derdeyn CP, Fiorella D, Lynn MJ, Turan TN, Lane BF, Janis LS, Chimowitz MI. Intracranial stenting: SAMMPRIS. Stroke. 2013 Jun; 44(6 Suppl 1):S41-4. PMID: 23709726.
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    54. Derdeyn CP, Fiorella D, Lynn MJ, Rumboldt Z, Cloft HJ, Gibson D, Turan TN, Lane BF, Janis LS, Chimowitz MI. Mechanisms of stroke after intracranial angioplasty and stenting in the SAMMPRIS trial. Neurosurgery. 2013 May; 72(5):777-95; discussion 795. PMID: 23328689.
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    55. Chimowitz MI. Endovascular treatment for acute ischemic stroke--still unproven. N Engl J Med. 2013 Mar 07; 368(10):952-5. PMID: 23394477.
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    56. Magarik JA, Jauch EC, Patel SJ, Adams RJ, Turner RD, Chaudry MI, Chalela JA, Hays A, Chimowitz MI, Turan TN, Holmstedt CA, Debenham E, Lackland DT, Turk AS. MUSC's comprehensive stroke program: changing what's possible in stroke care across South Carolina. J S C Med Assoc. 2012 Oct-Dec; 108(5):128-31. PMID: 23431916.
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    57. Chimowitz MI, Fiorella D, Derdeyn CP, Turan TN, Lane BF, Janis S, Lynn MJ. Response to critique of the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) trial by Abou-Chebl and Steinmetz. Stroke. 2012 Oct; 43(10):2806-9. PMID: 23180490.
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    58. Fiorella D, Derdeyn CP, Lynn MJ, Barnwell SL, Hoh BL, Levy EI, Harrigan MR, Klucznik RP, McDougall CG, Pride GL, Zaidat OO, Lutsep HL, Waters MF, Hourihane JM, Alexandrov AV, Chiu D, Clark JM, Johnson MD, Torbey MT, Rumboldt Z, Cloft HJ, Turan TN, Lane BF, Janis LS, Chimowitz MI. Detailed analysis of periprocedural strokes in patients undergoing intracranial stenting in Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS). Stroke. 2012 Oct; 43(10):2682-8. PMID: 22984008.
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    59. Derdeyn CP, Fiorella D, Lynn MJ, Barnwell SL, Zaidat OO, Meyers PM, Gobin YP, Dion J, Lane BF, Turan TN, Janis LS, Chimowitz MI. Impact of operator and site experience on outcomes after angioplasty and stenting in the SAMMPRIS trial. J Neurointerv Surg. 2013 Nov; 5(6):528-33. PMID: 22977278.
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    60. Derdeyn CP, Fiorella D, Chimowitz M. Response from the SAMMPRIS trial principal investigators regarding inaccuracies in this editorial. J Neurointerv Surg. 2016 Jun; 8(e1):e5-6. PMID: 22952246.
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    61. Turan TN, Lynn MJ, Nizam A, Lane B, Egan BM, Le NA, Lopes-Virella MF, Hermayer KL, Benavente O, White CL, Brown WV, Caskey MF, Steiner MR, Vilardo N, Stufflebean A, Derdeyn CP, Fiorella D, Janis S, Chimowitz MI. Rationale, design, and implementation of aggressive risk factor management in the Stenting and Aggressive Medical Management for Prevention of Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) trial. Circ Cardiovasc Qual Outcomes. 2012 Sep 01; 5(5):e51-60. PMID: 22991350.
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    62. Turk AS, Nyberg EM, Chaudry MI, Turner RD, Magarik JA, Nicholas JS, Holmstedt CA, Chalela JA, Hays A, Lazaridis C, Chimowitz MI, Turan TN, Adams RJ, Jauch EC. Utilization of CT perfusion patient selection for mechanical thrombectomy irrespective of time: a comparison of functional outcomes and complications. J Neurointerv Surg. 2013 Nov; 5(6):518-22. PMID: 22935349.
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    63. Adams RJ, Debenham E, Chalela J, Chimowitz M, Hays A, Hill C, Holmstedt C, Jauch E, Kitch A, Lazaridis C, Turan TN. REACH MUSC: A Telemedicine Facilitated Network for Stroke: Initial Operational Experience. Front Neurol. 2012; 3:33. PMID: 22435064.
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    64. Khan A, Kasner SE, Lynn MJ, Chimowitz MI. Risk factors and outcome of patients with symptomatic intracranial stenosis presenting with lacunar stroke. Stroke. 2012 May; 43(5):1230-3. PMID: 22363054.
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    65. Turk A, Magarik JA, Chaudry I, Turner RD, Nicholas J, Holmstedt CA, Chalela J, Hays A, Lazaridis C, Jauch E, Chimowitz M, Turan T, Adams R. CT perfusion-guided patient selection for endovascular treatment of acute ischemic stroke is safe and effective. J Neurointerv Surg. 2012 Jul; 4(4):261-5. PMID: 21990520.
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    66. Chimowitz MI, Lynn MJ, Derdeyn CP, Turan TN, Fiorella D, Lane BF, Janis LS, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL, Torbey MT, Zaidat OO, Rumboldt Z, Cloft HJ. Stenting versus aggressive medical therapy for intracranial arterial stenosis. N Engl J Med. 2011 Sep 15; 365(11):993-1003. PMID: 21899409.
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    67. Chimowitz MI, Lynn MJ, Turan TN, Fiorella D, Lane BF, Janis S, Derdeyn CP. Design of the stenting and aggressive medical management for preventing recurrent stroke in intracranial stenosis trial. J Stroke Cerebrovasc Dis. 2011 Jul-Aug; 20(4):357-68. PMID: 21729789.
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    68. Holmstedt C, Chimowitz M. E-pearl: brachial artery embolus mimicking acute stroke. Neurology. 2011 May 03; 76(18):e86-7. PMID: 21536631.
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    69. Cloft HJ, Lynn MJ, Feldmann E, Chimowitz M. Risk of cerebral angiography in patients with symptomatic intracranial atherosclerotic stenosis. Cerebrovasc Dis. 2011; 31(6):588-91. PMID: 21487224.
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    70. Turan TN, Bonilha L, Morgan PS, Adams RJ, Chimowitz MI. Intraplaque hemorrhage in symptomatic intracranial atherosclerotic disease. J Neuroimaging. 2011 Apr; 21(2):e159-61. PMID: 19909397.
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    71. Liebeskind DS, Cotsonis GA, Saver JL, Lynn MJ, Turan TN, Cloft HJ, Chimowitz MI. Collaterals dramatically alter stroke risk in intracranial atherosclerosis. Ann Neurol. 2011 Jun; 69(6):963-74. PMID: 21437932.
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    72. Chimowitz MI, Frank Lafranchise E, Furlan AJ, Dorosti K, Paranandi L, Beck GJ. Evaluation of coexistent carotid and coronary disease by combined angiography. J Stroke Cerebrovasc Dis. 1991; 1(2):89-93. PMID: 26487600.
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    73. Liebeskind DS, Cotsonis GA, Saver JL, Lynn MJ, Cloft HJ, Chimowitz MI. Collateral circulation in symptomatic intracranial atherosclerosis. J Cereb Blood Flow Metab. 2011 May; 31(5):1293-301. PMID: 21157476.
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    74. Turan TN, Chimowitz MI. 10 questions about intracranial atherosclerotic stenosis. Neurologist. 2010 Nov; 16(6):400-5. PMID: 21150394.
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    75. Turan TN, Makki AA, Tsappidi S, Cotsonis G, Lynn MJ, Cloft HJ, Chimowitz MI. Risk factors associated with severity and location of intracranial arterial stenosis. Stroke. 2010 Aug; 41(8):1636-40. PMID: 20616323.
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    76. Greenfield LJ, Chimowitz MI, Quint DJ, Wakefield TW. Contralateral reperfusion injury after carotid endarterectomy. J Stroke Cerebrovasc Dis. 1994; 4(4):203-6. PMID: 26486236.
      Citations:    
    77. Fiorella D, Turan TN, Derdeyn CP, Chimowitz MI. Current status of the management of symptomatic intracranial atherosclerotic disease: the rationale for a randomized trial of medical therapy and intracranial stenting. J Neurointerv Surg. 2009 Jul; 1(1):35-9. PMID: 21994103.
      Citations:    
    78. Turan TN, Derdeyn CP, Fiorella D, Chimowitz MI. Treatment of atherosclerotic intracranial arterial stenosis. Stroke. 2009 Jun; 40(6):2257-61. PMID: 19407238.
      Citations:    
    79. Famakin BM, Chimowitz MI, Lynn MJ, Stern BJ, George MG. Causes and severity of ischemic stroke in patients with symptomatic intracranial arterial stenosis. Stroke. 2009 Jun; 40(6):1999-2003. PMID: 19407228.
      Citations:    
    80. Nahab F, Lynn MJ, Kasner SE, Alexander MJ, Klucznik R, Zaidat OO, Chaloupka J, Lutsep H, Barnwell S, Mawad M, Lane B, Chimowitz MI. Risk factors associated with major cerebrovascular complications after intracranial stenting. Neurology. 2009 Jun 09; 72(23):2014-9. PMID: 19299309.
      Citations:    
    81. Turan TN, Maidan L, Cotsonis G, Lynn MJ, Romano JG, Levine SR, Chimowitz MI. Failure of antithrombotic therapy and risk of stroke in patients with symptomatic intracranial stenosis. Stroke. 2009 Feb; 40(2):505-9. PMID: 19095991.
      Citations:    
    82. Waddy SP, Cotsonis G, Lynn MJ, Frankel MR, Chaturvedi S, Williams JE, Chimowitz M. Racial differences in vascular risk factors and outcomes of patients with intracranial atherosclerotic arterial stenosis. Stroke. 2009 Mar; 40(3):719-25. PMID: 18832745.
      Citations:    
    83. Ovbiagele B, Cruz-Flores S, Lynn MJ, Chimowitz MI. Early stroke risk after transient ischemic attack among individuals with symptomatic intracranial artery stenosis. Arch Neurol. 2008 Jun; 65(6):733-7. PMID: 18541793.
      Citations:    
    84. Derdeyn CP, Chimowitz MI. Re: Turk et al and the "how do we spin wingspan?" commentary. AJNR Am J Neuroradiol. 2008 Sep; 29(8):e69; author reply e70. PMID: 18388209.
      Citations:    
    85. Nahab F, Cotsonis G, Lynn M, Feldmann E, Chaturvedi S, Hemphill JC, Zweifler R, Johnston K, Bonovich D, Kasner S, Chimowitz M. Prevalence and prognosis of coexistent asymptomatic intracranial stenosis. Stroke. 2008 Mar; 39(3):1039-41. PMID: 18239161.
      Citations:    
    86. Zaidat OO, Klucznik R, Alexander MJ, Chaloupka J, Lutsep H, Barnwell S, Mawad M, Lane B, Lynn MJ, Chimowitz M. The NIH registry on use of the Wingspan stent for symptomatic 70-99% intracranial arterial stenosis. Neurology. 2008 Apr 22; 70(17):1518-24. PMID: 18235078.
      Citations:    
    87. Hertzberg V, Chimowitz M, Lynn M, Chester C, Asbury W, Cotsonis G. Use of dose modification schedules is effective for blinding trials of warfarin: evidence from the WASID study. Clin Trials. 2008; 5(1):23-30. PMID: 18283076.
      Citations:    
    88. Turan TN, Chimowitz MI. Treatment of intracranial atherosclerotic stenosis. Rev Neurol Dis. 2008; 5(3):117-24. PMID: 18838951.
      Citations:    
    89. Chaturvedi S, Turan TN, Lynn MJ, Kasner SE, Romano J, Cotsonis G, Frankel M, Chimowitz MI. Risk factor status and vascular events in patients with symptomatic intracranial stenosis. Neurology. 2007 Nov 27; 69(22):2063-8. PMID: 18040012.
      Citations:    
    90. Kasner SE, Lynn MJ, Jackson BP, Pullicino PM, Chimowitz MI. Echocardiography in patients with symptomatic intracranial stenosis. J Stroke Cerebrovasc Dis. 2007 Sep-Oct; 16(5):216-9. PMID: 17845919.
      Citations:    
    91. Derdeyn CP, Chimowitz MI. Angioplasty and stenting for atherosclerotic intracranial stenosis: rationale for a randomized clinical trial. Neuroimaging Clin N Am. 2007 Aug; 17(3):355-63, viii-ix. PMID: 17826637.
      Citations:    
    92. Ovbiagele B, Lynn MJ, Saver JL, Chimowitz MI. Leukocyte count and vascular risk in symptomatic intracranial atherosclerosis. Cerebrovasc Dis. 2007; 24(2-3):283-8. PMID: 17646693.
      Citations:    
    93. Williams JE, Chimowitz MI, Cotsonis GA, Lynn MJ, Waddy SP. Gender differences in outcomes among patients with symptomatic intracranial arterial stenosis. Stroke. 2007 Jul; 38(7):2055-62. PMID: 17540969.
      Citations:    
    94. Turan TN, Cotsonis G, Lynn MJ, Chaturvedi S, Chimowitz M. Relationship between blood pressure and stroke recurrence in patients with intracranial arterial stenosis. Circulation. 2007 Jun 12; 115(23):2969-75. PMID: 17515467.
      Citations:    
    95. Feldmann E, Wilterdink JL, Kosinski A, Lynn M, Chimowitz MI, Sarafin J, Smith HH, Nichols F, Rogg J, Cloft HJ, Wechsler L, Saver J, Levine SR, Tegeler C, Adams R, Sloan M. The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) trial. Neurology. 2007 Jun 12; 68(24):2099-106. PMID: 17409371.
      Citations:    
    96. Kasner SE, Lynn MJ, Chimowitz MI, Frankel MR, Howlett-Smith H, Hertzberg VS, Chaturvedi S, Levine SR, Stern BJ, Benesch CG, Jovin TG, Sila CA, Romano JG. Warfarin vs aspirin for symptomatic intracranial stenosis: subgroup analyses from WASID. Neurology. 2006 Oct 10; 67(7):1275-8. PMID: 17030766.
      Citations:    
    97. Ovbiagele B, Saver JL, Lynn MJ, Chimowitz M. Impact of metabolic syndrome on prognosis of symptomatic intracranial atherostenosis. Neurology. 2006 May 09; 66(9):1344-9. PMID: 16682665.
      Citations:    
    98. Kasner SE, Chimowitz MI, Lynn MJ, Howlett-Smith H, Stern BJ, Hertzberg VS, Frankel MR, Levine SR, Chaturvedi S, Benesch CG, Sila CA, Jovin TG, Romano JG, Cloft HJ. Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis. Circulation. 2006 Jan 31; 113(4):555-63. PMID: 16432056.
      Citations:    
    99. Ehtisham A, Chimowitz MI, Furlan AJ, Lafranchise EF. Systemic risk factors associated with progression of atherosclerosis from the coronary to the carotid arteries. J Stroke Cerebrovasc Dis. 2005 Jul-Aug; 14(4):182-5. PMID: 17904023.
      Citations:    
    100. Ehtisham A, Chimowitz MI. A clinical example of the "limping brain" syndrome: a case report. AJNR Am J Neuroradiol. 2005 Jun-Jul; 26(6):1521-4. PMID: 15956524.
      Citations:    
    101. Chimowitz MI, Lynn MJ, Howlett-Smith H, Stern BJ, Hertzberg VS, Frankel MR, Levine SR, Chaturvedi S, Kasner SE, Benesch CG, Sila CA, Jovin TG, Romano JG. Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis. N Engl J Med. 2005 Mar 31; 352(13):1305-16. PMID: 15800226.
      Citations:    
    102. Adams RJ, Chimowitz MI, Alpert JS, Awad IA, Cerqueria MD, Fayad P, Taubert KA. Coronary risk evaluation in patients with transient ischemic attack and ischemic stroke: a scientific statement for healthcare professionals from the Stroke Council and the Council on Clinical Cardiology of the American Heart Association/American Stroke Association. Circulation. 2003 Sep 09; 108(10):1278-90. PMID: 12963684.
      Citations:    
    103. Adams RJ, Chimowitz MI, Alpert JS, Awad IA, Cerqueria MD, Fayad P, Taubert KA. Coronary risk evaluation in patients with transient ischemic attack and ischemic stroke: a scientific statement for healthcare professionals from the Stroke Council and the Council on Clinical Cardiology of the American Heart Association/American Stroke Association. Stroke. 2003 Sep; 34(9):2310-22. PMID: 12958318.
      Citations:    
    104. Chimowitz MI. Antithrombotic therapy for atherosclerotic intracranial arterial stenosis. Adv Neurol. 2003; 92:271-4. PMID: 12760193.
      Citations:    
    105. Austin H, Chimowitz MI, Hill HA, Chaturvedi S, Wechsler LR, Wityk RJ, Walz E, Wilterdink JL, Coull B, Sila CA, Mitsias P, Evatt B, Hooper WC. Cryptogenic stroke in relation to genetic variation in clotting factors and other genetic polymorphisms among young men and women. Stroke. 2002 Dec; 33(12):2762-8. PMID: 12468767.
      Citations:    
    106. Chimowitz MI. Angioplasty or stenting is not appropriate as first-line treatment of intracranial stenosis. Arch Neurol. 2001 Oct; 58(10):1690-2. PMID: 11594932.
      Citations:    
    107. Benesch CG, Chimowitz MI. Best treatment for intracranial arterial stenosis? 50 years of uncertainty. The WASID Investigators. Neurology. 2000 Aug 22; 55(4):465-6. PMID: 10953174.
      Citations:    
    108. Samuels OB, Joseph GJ, Lynn MJ, Smith HA, Chimowitz MI. A standardized method for measuring intracranial arterial stenosis. AJNR Am J Neuroradiol. 2000 Apr; 21(4):643-6. PMID: 10782772.
      Citations:    
    109. Chimowitz MI, Poole RM, Starling MR, Schwaiger M, Gross MD. Frequency and severity of asymptomatic coronary disease in patients with different causes of stroke. Stroke. 1997 May; 28(5):941-5. PMID: 9158629.
      Citations:    
    110. Chimowitz MI, Kokkinos J, Strong J, Brown MB, Levine SR, Silliman S, Pessin MS, Weichel E, Sila CA, Furlan AJ, et al. The Warfarin-Aspirin Symptomatic Intracranial Disease Study. Neurology. 1995 Aug; 45(8):1488-93. PMID: 7644046.
      Citations:    
    111. DeGeorgia MA, Chimowitz MI, Hepner A, Armstrong WF. Right atrial spontaneous contrast: echocardiographic and clinical features. Int J Card Imaging. 1994 Sep; 10(3):227-32. PMID: 7876662.
      Citations:    
    112. Poole RM, Chimowitz MI. Ischemic stroke and TIA: clinical clues to common causes. Geriatrics. 1994 Jun; 49(6):37-42. PMID: 7911776.
      Citations:    
    113. Chimowitz MI, Weiss DG, Cohen SL, Starling MR, Hobson RW. Cardiac prognosis of patients with carotid stenosis and no history of coronary artery disease. Veterans Affairs Cooperative Study Group 167. Stroke. 1994 Apr; 25(4):759-65. PMID: 8160217.
      Citations:    
    114. Cohen SN, Hobson RW, Weiss DG, Chimowitz M. Death associated with asymptomatic carotid artery stenosis: long-term clinical evaluation. VA Cooperative Study 167 Group. J Vasc Surg. 1993 Dec; 18(6):1002-9; discussion 1009-11. PMID: 8264028.
      Citations:    
    115. Chimowitz MI, DeGeorgia MA, Poole RM, Hepner A, Armstrong WM. Left atrial spontaneous echo contrast is highly associated with previous stroke in patients with atrial fibrillation or mitral stenosis. Stroke. 1993 Jul; 24(7):1015-9. PMID: 8322375.
      Citations:    
    116. Chimowitz MI, Furlan AJ, Jones SC, Sila CA, Lorig RL, Paranandi L, Beck GJ. Transcranial Doppler assessment of cerebral perfusion reserve in patients with carotid occlusive disease and no evidence of cerebral infarction. Neurology. 1993 Feb; 43(2):353-7. PMID: 8437702.
      Citations:    
    117. Chimowitz MI, Estes ML, Furlan AJ, Awad IA. Further observations on the pathology of subcortical lesions identified on magnetic resonance imaging. Arch Neurol. 1992 Jul; 49(7):747-52. PMID: 1497503.
      Citations:    
    118. Chimowitz MI, Mancini GB. Asymptomatic coronary artery disease in patients with stroke. Prevalence, prognosis, diagnosis, and treatment. Stroke. 1992 Mar; 23(3):433-6. PMID: 1542910.
      Citations:    
    119. Furlan AJ, Sila CA, Chimowitz MI, Jones SC. Neurologic complications related to cardiac surgery. Neurol Clin. 1992 Feb; 10(1):145-66. PMID: 1557000.
      Citations:    
    120. Chimowitz MI, Nemec JJ, Marwick TH, Lorig RJ, Furlan AJ, Salcedo EE. Transcranial Doppler ultrasound identifies patients with right-to-left cardiac or pulmonary shunts. Neurology. 1991 Dec; 41(12):1902-4. PMID: 1745345.
      Citations:    
    121. Nemec JJ, Marwick TH, Lorig RJ, Davison MB, Chimowitz MI, Litowitz H, Salcedo EE. Comparison of transcranial Doppler ultrasound and transesophageal contrast echocardiography in the detection of interatrial right-to-left shunts. Am J Cardiol. 1991 Dec 01; 68(15):1498-502. PMID: 1746433.
      Citations:    
    122. Chimowitz MI, Furlan AJ, Sila CA, Paranandi L, Beck GJ. Etiology of motor or sensory stroke: a prospective study of the predictive value of clinical and radiological features. Ann Neurol. 1991 Oct; 30(4):519-25. PMID: 1789681.
      Citations:    
    123. Estes ML, Chimowitz MI, Awad IA, McMahon JT, Furlan AJ, Ratliff NB. Sclerosing vasculopathy of the central nervous system in nonelderly demented patients. Arch Neurol. 1991 Jun; 48(6):631-6. PMID: 2039386.
      Citations:    
    124. Chimowitz MI, Barnett GH, Palmer J. Treatment of intractable arterial hemorrhage during stereotactic brain biopsy with thrombin. Report of three patients. J Neurosurg. 1991 Feb; 74(2):301-3. PMID: 1988604.
      Citations:    
    125. Nemec JJ, Davison MB, Marwick TH, Chimowitz MI, Stoller JK, Klein AL, Salcedo EE. Detection and evaluation of intrapulmonary vascular shunt with "contrast Doppler" transesophageal echocardiography. J Am Soc Echocardiogr. 1991 Jan-Feb; 4(1):79-83. PMID: 2003943.
      Citations:    
    126. Chimowitz MI, Furlan AJ, Nayak S, Sila CA. Mechanism of stroke in patients taking aspirin. Neurology. 1990 Nov; 40(11):1682-5. PMID: 2146524.
      Citations:    
    127. Chimowitz MI, Lafranchise EF, Furlan AJ, Awad IA. Ipsilateral leg weakness associated with carotid stenosis. Stroke. 1990 Sep; 21(9):1362-4. PMID: 2396275.
      Citations:    
    128. Chimowitz MI, Furlan AJ. Resolution of psychotic depression after right temporoparietal infarction. J Nerv Ment Dis. 1990 Jul; 178(7):458-9. PMID: 2366060.
      Citations:    
    129. Chimowitz MI, Logigian EL, Caplan LR. The accuracy of bedside neurological diagnoses. Ann Neurol. 1990 Jul; 28(1):78-85. PMID: 2375637.
      Citations:    
    130. Chimowitz MI, Little JR, Awad IA, Sila CA, Kosmorsky G, Furlan AJ. Intracranial hypertension associated with unruptured cerebral arteriovenous malformations. Ann Neurol. 1990 May; 27(5):474-9. PMID: 2193610.
      Citations:    
    131. Chimowitz MI, Audet AM, Hallet A, Kelly JJ. HIV-associated CIDP. Muscle Nerve. 1989 Aug; 12(8):695-6. PMID: 2779608.
      Citations:    
    132. Chimowitz MI, Awad IA, Furlan AJ. Periventricular lesions on MRI. Facts and theories. Stroke. 1989 Jul; 20(7):963-7. PMID: 2749855.
      Citations:    
    133. Pessin MS, Chimowitz MI, Levine SR, Kwan ES, Adelman LS, Earnest MP, Clark DM, Chason J, Ausman JI, Caplan LR. Stroke in patients with fusiform vertebrobasilar aneurysms. Neurology. 1989 Jan; 39(1):16-21. PMID: 2909908.
      Citations:    
    134. Chimowitz MI, Pessin MS. Is there a role for heparin in the management of complications of subarachnoid hemorrhage? Stroke. 1987 Nov-Dec; 18(6):1169-72. PMID: 3318003.
      Citations:    
    135. Chimowitz MI, Mare N, Beighton P. A computerized genetic record system. S Afr Med J. 1984 Feb 11; 65(6):206-9. PMID: 6546455.
      Citations:    
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