Paul J. McDermott

TitleAssociate Dean for Faculty Affairs and Faculty Development
InstitutionMedical University of South Carolina
DepartmentCardiology
AddressP.O. Box MSC 773
STB 250
Thurmond Gazes - 30 Courtenay Drive
Phone843-792-3462
Fax843-876-5068
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. McDermott P, Wolfe E, Lowry C, Robinson K, French HP. Evaluating the immediate effects of wearing foot orthotics in children with Joint Hypermobility Syndrome (JHS) by analysis of temperospatial parameters of gait and dynamic balance: A preliminary study. Gait Posture. 2018 02; 60:61-64. PMID: 29156379.
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    2. Cunningham KF, Beeson GC, Beeson CC, McDermott PJ. Increased expression of estrogen-related receptor ß during adaptation of adult cardiomyocytes to sustained hypoxia. Am J Cardiovasc Dis. 2016; 6(2):46-54. PMID: 27335690.
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    3. Cunningham KF, Beeson GC, Beeson CC, Baicu CF, Zile MR, McDermott PJ. Estrogen-Related Receptor a (ERRa) is required for adaptive increases in PGC-1 isoform expression during electrically stimulated contraction of adult cardiomyocytes in sustained hypoxic conditions. Int J Cardiol. 2015; 187:393-400. PMID: 25841134.
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    4. Kendall RT, Lee MH, Pleasant DL, Robinson K, Kuppuswamy D, McDermott PJ, Luttrell LM. Arrestin-dependent angiotensin AT1 receptor signaling regulates Akt and mTor-mediated protein synthesis. J Biol Chem. 2014 Sep 19; 289(38):26155-26166. PMID: 25081544.
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    5. Zavadzkas JA, Stroud RE, Bouges S, Mukherjee R, Jones JR, Patel RK, McDermott PJ, Spinale FG. Targeted overexpression of tissue inhibitor of matrix metalloproteinase-4 modifies post-myocardial infarction remodeling in mice. Circ Res. 2014 Apr 25; 114(9):1435-45. PMID: 24637197.
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    6. McDermott PJ, Baicu CF, Wahl SR, Van Laer AO, Zile MR. In vivo measurements of the contributions of protein synthesis and protein degradation in regulating cardiac pressure overload hypertrophy in the mouse. Mol Cell Biochem. 2012 Aug; 367(1-2):205-13. PMID: 22610791.
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    7. Tholanikunnel BG, Joseph K, Kandasamy K, Baldys A, Raymond JR, Luttrell LM, McDermott PJ, Fernandes DJ. Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membrane. J Biol Chem. 2010 Oct 29; 285(44):33816-25. PMID: 20739277.
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    8. Whyteside AR, Hinsley EE, Lambert LA, McDermott PJ, Turner AJ. ECE-1 influences prostate cancer cell invasion via ET-1-mediated FAK phosphorylation and ET-1-independent mechanisms. Can J Physiol Pharmacol. 2010 Aug; 88(8):850-4. PMID: 20725143.
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    9. Lucchini S, McDermott P, Thompson A, Hinton JC. The H-NS-like protein StpA represses the RpoS (sigma 38) regulon during exponential growth of Salmonella Typhimurium. Mol Microbiol. 2009 Dec; 74(5):1169-86. PMID: 19843227.
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    10. Spruill LS, McDermott PJ. Role of the 5'-untranslated region in regulating translational efficiency of specific mRNAs in adult cardiocytes. FASEB J. 2009 Sep; 23(9):2879-87. PMID: 19417087.
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    11. McDermott P, Connolly V, Kavanagh TA. The mitochondrial genome of a cytoplasmic male sterile line of perennial ryegrass (Lolium perenne L.) contains an integrated linear plasmid-like element. Theor Appl Genet. 2008 Aug; 117(3):459-70. PMID: 18504541.
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    12. Cai Y, Wang Q, Ling Z, Pipeleers D, McDermott P, Pende M, Heimberg H, Van de Casteele M. Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR. Biochem Pharmacol. 2008 May 15; 75(10):1981-93. PMID: 18377870.
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    13. Spruill LS, Baicu CF, Zile MR, McDermott PJ. Selective translation of mRNAs in the left ventricular myocardium of the mouse in response to acute pressure overload. J Mol Cell Cardiol. 2008 Jan; 44(1):69-75. PMID: 18036610.
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    14. Tuxworth WJ, Shiraishi H, Moschella PC, Yamane K, McDermott PJ, Kuppuswamy D. Translational activation of 5'-TOP mRNA in pressure overload myocardium. Basic Res Cardiol. 2008 Jan; 103(1):41-53. PMID: 17955327.
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    15. Moschella PC, Rao VU, McDermott PJ, Kuppuswamy D. Regulation of mTOR and S6K1 activation by the nPKC isoforms, PKCepsilon and PKCdelta, in adult cardiac muscle cells. J Mol Cell Cardiol. 2007 Dec; 43(6):754-66. PMID: 17976640.
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    16. Spruill LS, Lowry AS, Stroud RE, Squires CE, Mains IM, Flack EC, Beck C, Ikonomidis JS, Crumbley AJ, McDermott PJ, Spinale FG. Membrane-type-1 matrix metalloproteinase transcription and translation in myocardial fibroblasts from patients with normal left ventricular function and from patients with cardiomyopathy. . 2007 Oct; 293(4):C1362-73. PMID: 17670887.
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    17. White SJ, Kasman LM, Kelly MM, Lu P, Spruill L, McDermott PJ, Voelkel-Johnson C. Doxorubicin generates a proapoptotic phenotype by phosphorylation of elongation factor 2. Free Radic Biol Med. 2007 Nov 01; 43(9):1313-21. PMID: 17893044.
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    18. Spruill LS, McDermott PJ. Regulation of c-jun mRNA expression in adult cardiocytes by MAP kinase interacting kinase-1 (MNK1). FASEB J. 2006 Oct; 20(12):2133-5. PMID: 16940435.
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    19. Scholz D, McDermott P, Garnovskaya M, Gallien TN, Huettelmaier S, DeRienzo C, Cooper G. Microtubule-associated protein-4 (MAP-4) inhibits microtubule-dependent distribution of mRNA in isolated neonatal cardiocytes. Cardiovasc Res. 2006 Aug 01; 71(3):506-16. PMID: 16750521.
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    20. McDermott PJ, Stockman RA. Combining two-directional synthesis and tandem reactions: synthesis of trioxadispiroketals. Org Lett. 2005 Jan 06; 7(1):27-9. PMID: 15624969.
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    21. Rao VU, Shiraishi H, McDermott PJ. PKC-epsilon regulation of extracellular signal-regulated kinase: a potential role in phenylephrine-induced cardiocyte growth. . 2004 Jun; 286(6):H2195-203. PMID: 14975926.
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    22. Tuxworth WJ, Saghir AN, Spruill LS, Menick DR, McDermott PJ. Regulation of protein synthesis by eIF4E phosphorylation in adult cardiocytes: the consequence of secondary structure in the 5'-untranslated region of mRNA. Biochem J. 2004 Feb 15; 378(Pt 1):73-82. PMID: 14629199.
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    23. Takahashi M, Shiraishi H, Ishibashi Y, Blade KL, McDermott PJ, Menick DR, Kuppuswamy D, Cooper G. Phenotypic consequences of beta1-tubulin expression and MAP4 decoration of microtubules in adult cardiocytes. . 2003 Nov; 285(5):H2072-83. PMID: 12855424.
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    24. Iijima Y, Laser M, Shiraishi H, Willey CD, Sundaravadivel B, Xu L, McDermott PJ, Kuppuswamy D. c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells. J Biol Chem. 2002 Jun 21; 277(25):23065-75. PMID: 11940578.
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    25. Sato M, Shegogue D, Gore EA, Smith EA, McDermott PJ, Trojanowska M. Role of p38 MAPK in transforming growth factor beta stimulation of collagen production by scleroderma and healthy dermal fibroblasts. J Invest Dermatol. 2002 Apr; 118(4):704-11. PMID: 11918720.
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    26. Zhang XQ, Song J, Rothblum LI, Lun M, Wang X, Ding F, Dunn J, Lytton J, McDermott PJ, Cheung JY. Overexpression of Na+/Ca2+ exchanger alters contractility and SR Ca2+ content in adult rat myocytes. . 2001 Nov; 281(5):H2079-88. PMID: 11668069.
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    27. Saghir AN, Tuxworth WJ, Hagedorn CH, McDermott PJ. Modifications of eukaryotic initiation factor 4F (eIF4F) in adult cardiocytes by adenoviral gene transfer: differential effects on eIF4F activity and total protein synthesis rates. Biochem J. 2001 Jun 01; 356(Pt 2):557-66. PMID: 11368785.
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    28. Makhlouf AA, Namboodiri AM, McDermott PJ. Transcriptional regulation of the rat eIF4E gene in cardiac muscle cells: the role of specific elements in the promoter region. Gene. 2001 Apr 04; 267(1):1-12. PMID: 11311550.
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    29. Nagatomo Y, Carabello BA, Coker ML, McDermott PJ, Nemoto S, Hamawaki M, Spinale FG. Differential effects of pressure or volume overload on myocardial MMP levels and inhibitory control. . 2000 Jan; 278(1):H151-61. PMID: 10644594.
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    30. Nagatomo Y, Carabello BA, Hamawaki M, Nemoto S, Matsuo T, McDermott PJ. Translational mechanisms accelerate the rate of protein synthesis during canine pressure-overload hypertrophy. Am J Physiol. 1999 12; 277(6):H2176-84. PMID: 10600835.
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    31. Tuxworth WJ, Wada H, Ishibashi Y, McDermott PJ. Role of load in regulating eIF-4F complex formation in adult feline cardiocytes. Am J Physiol. 1999 10; 277(4):H1273-82. PMID: 10516161.
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    32. Matsuo T, Carabello BA, Nagatomo Y, Koide M, Hamawaki M, Zile MR, McDermott PJ. Mechanisms of cardiac hypertrophy in canine volume overload. Am J Physiol. 1998 Jul; 275(1 Pt 2):H65-74. PMID: 9688897.
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    33. Makhlouf AA, McDermott PJ. Increased expression of eukaryotic initiation factor 4E during growth of neonatal rat cardiocytes in vitro. Am J Physiol. 1998 06; 274(6):H2133-42. PMID: 9841540.
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    34. Yang Q, McDermott PJ, Duzic E, Pleij CW, Sherlock JD, Lanier SM. The 3'-untranslated region of the alpha2C-adrenergic receptor mRNA impedes translation of the receptor message. J Biol Chem. 1997 Jun 13; 272(24):15466-73. PMID: 9182579.
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    35. Wada H, Zile MR, Ivester CT, Cooper G, McDermott PJ. Comparative effects of contraction and angiotensin II on growth of adult feline cardiocytes in primary culture. Am J Physiol. 1996 Jul; 271(1 Pt 2):H29-37. PMID: 8760154.
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    36. Kent RL, McDermott PJ. Passive load and angiotensin II evoke differential responses of gene expression and protein synthesis in cardiac myocytes. Circ Res. 1996 May; 78(5):829-38. PMID: 8620603.
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    37. Wada H, Ivester CT, Carabello BA, Cooper G, McDermott PJ. Translational initiation factor eIF-4E. A link between cardiac load and protein synthesis. J Biol Chem. 1996 Apr 05; 271(14):8359-64. PMID: 8626533.
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    38. Tagawa H, Rozich JD, Tsutsui H, Narishige T, Kuppuswamy D, Sato H, McDermott PJ, Koide M, Cooper G. Basis for increased microtubules in pressure-hypertrophied cardiocytes. Circulation. 1996 Mar 15; 93(6):1230-43. PMID: 8653846.
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    39. Ivester CT, Tuxworth WJ, Cooper G, McDermott PJ. Contraction accelerates myosin heavy chain synthesis rates in adult cardiocytes by an increase in the rate of translational initiation. J Biol Chem. 1995 Sep 15; 270(37):21950-7. PMID: 7665617.
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    40. Neumar RW, DeGracia DJ, White BC, McDermott PJ, Evans DR, Krause GS. Eukaryotic initiation factor 4E degradation during brain ischemia. J Neurochem. 1995 Sep; 65(3):1391-4. PMID: 7643117.
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    41. Kato S, Ivester CT, Cooper G, Zile MR, McDermott PJ. Growth effects of electrically stimulated contraction on adult feline cardiocytes in primary culture. Am J Physiol. 1995 Jun; 268(6 Pt 2):H2495-504. PMID: 7611500.
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    42. Rozich JD, Barnes MA, Schmid PG, Zile MR, McDermott PJ, Cooper G. Load effects on gene expression during cardiac hypertrophy. J Mol Cell Cardiol. 1995 Jan; 27(1):485-99. PMID: 7760368.
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    43. Imamura T, McDermott PJ, Kent RL, Nagatsu M, Cooper G, Carabello BA. Acute changes in myosin heavy chain synthesis rate in pressure versus volume overload. Circ Res. 1994 Sep; 75(3):418-25. PMID: 8062416.
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    44. Johnson TB, Kent RL, Bubolz BA, McDermott PJ. Electrical stimulation of contractile activity accelerates growth of cultured neonatal cardiocytes. Circ Res. 1994 Mar; 74(3):448-59. PMID: 8118953.
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    45. Kent RL, Rozich JD, McCollam PL, McDermott DE, Thacker UF, Menick DR, McDermott PJ, Cooper G. Rapid expression of the Na(+)-Ca2+ exchanger in response to cardiac pressure overload. Am J Physiol. 1993 Sep; 265(3 Pt 2):H1024-9. PMID: 8214109.
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    46. Ivester CT, Kent RL, Tagawa H, Tsutsui H, Imamura T, Cooper G, McDermott PJ. Electrically stimulated contraction accelerates protein synthesis rates in adult feline cardiocytes. Am J Physiol. 1993 Aug; 265(2 Pt 2):H666-74. PMID: 8368369.
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    47. Allo SN, McDermott PJ, Carl LL, Morgan HE. Phorbol ester stimulation of protein kinase C activity and ribosomal DNA transcription. Role in hypertrophic growth of cultured cardiomyocytes. J Biol Chem. 1991 Nov 15; 266(32):22003-9. PMID: 1939221.
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    48. Foster KA, McDermott PJ, Robishaw JD. The effect of culture and membrane potential on Go alpha expression in neonatal rat cardiac myocytes. Mol Cell Biochem. 1991 May 29-Jun 12; 104(1-2):63-72. PMID: 1922003.
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    49. Haneda T, McDermott PJ. Stimulation of ribosomal RNA synthesis during hypertrophic growth of cultured heart cells by phorbol ester. Mol Cell Biochem. 1991 May 29-Jun 12; 104(1-2):169-77. PMID: 1921997.
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    50. McDermott PJ, Carl LL, Conner KJ, Allo SN. Transcriptional regulation of ribosomal RNA synthesis during growth of cardiac myocytes in culture. J Biol Chem. 1991 Mar 05; 266(7):4409-16. PMID: 1999424.
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    51. Foster KA, McDermott PJ, Robishaw JD. Expression of G proteins in rat cardiac myocytes: effect of KCl depolarization. Am J Physiol. 1990 Aug; 259(2 Pt 2):H432-41. PMID: 2117401.
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    52. McDermott PJ, Rothblum LI, Smith SD, Morgan HE. Accelerated rates of ribosomal RNA synthesis during growth of contracting heart cells in culture. J Biol Chem. 1989 Oct 25; 264(30):18220-7. PMID: 2808374.
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    53. McDermott PJ, Morgan HE. Contraction modulates the capacity for protein synthesis during growth of neonatal heart cells in culture. Circ Res. 1989 Mar; 64(3):542-53. PMID: 2465098.
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    54. McDermott P, Whitaker-Dowling P, Klein I. Regulation of cardiac myosin synthesis: studies of RNA content in cultured heart cells. Exp Cell Res. 1987 Nov; 173(1):183-92. PMID: 3678378.
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    55. McDermott P, Daood M, Klein I. Contraction regulates myosin synthesis and myosin content of cultured heart cells. Am J Physiol. 1985 Oct; 249(4 Pt 2):H763-9. PMID: 2931998.
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