Robert J. Malcolm

TitleAssociate Dean for Continuing Medical Education
InstitutionMedical University of South Carolina
DepartmentPsychiatry and Behavioral Sciences
AddressP.O. Box MSC 861
459N
67 President St.
Phone843-792-5209
Fax843-792-7353
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    Dr. Malcolm's principal research interests are in the area of medication treatment development for multiple addictive agents including alcohol, cocaine and marijuana. He also has a research interest in eating behaviors, especially obesity and binge eating disorders. Dr. Malcolm is a principal investigator currently funded by the NIH to study a medication to block marijuana addiction and to study a drug to prevent relapse to cocaine addiction. He is also funded by private pharmaceutical companies to evaluate drugs to prevent relapse in schizophrenia and is evaluating a medication for treatment resistant depression.
    Collapse keywords
    Depression, Mental Health, Diabetes, Drug Studies, Obesity, Psychiatry, Weight Control, cocaine dependence, alcohol use disorders, obesity, marijuana, smoking cessation

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Marriott BP, Turner TH, Hibbeln JR, Newman JC, Pregulman M, Malek AM, Malcolm RJ, Burbelo GA, Wismann JW. Impact of Fatty Acid Supplementation on Cognitive Performance among United States (US) Military Officers: The Ranger Resilience and Improved Performance on Phospholipid-Bound Omega-3's (RRIPP-3) Study. Nutrients. 2021 May 29; 13(6). PMID: 34072293.
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    2. Back SE, Gray K, Santa Ana E, Jones JL, Jarnecke AM, Joseph JE, Prisciandaro J, Killeen T, Brown DG, Taimina L, Compean E, Malcolm R, Flanagan JC, Kalivas PW. N-acetylcysteine for the treatment of comorbid alcohol use disorder and posttraumatic stress disorder: Design and methodology of a randomized clinical trial. Contemp Clin Trials. 2020 04; 91:105961. PMID: 32087337.
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    3. Schulte EM, Tuerk PW, Wadden TA, Garvey WT, Weiss D, Hermayer KL, Aronne LJ, Becker LE, Fujioka K, Miller-Kovach K, Kushner RF, Malcolm RJ, Raum WJ, Rost SL, Rubino DM, Sora ND, Veliko JL, O'Neil PM. Changes in weight control behaviors and hedonic hunger in a commercial weight management program adapted for individuals with type 2 diabetes. Int J Obes (Lond). 2020 05; 44(5):990-998. PMID: 31949295.
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    4. Boepple L, Cero I, Marek RJ, Coulon S, Lydecker JA, Brown JD, Malcolm R, O'Neil PM. Patients' reasons for weight loss and their relations to clinical weight loss outcomes in a comprehensive lifestyle intervention. Obes Sci Pract. 2019 Dec; 5(6):548-554. PMID: 31890245.
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    5. Sahlem GL, Caruso MA, Short EB, Fox JB, Sherman BJ, Manett AJ, Malcolm RJ, George MS, McRae-Clark AL. A case series exploring the effect of twenty sessions of repetitive transcranial magnetic stimulation (rTMS) on cannabis use and craving. Brain Stimul. 2020 Jan - Feb; 13(1):265-266. PMID: 31619347.
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    6. Marriott BP, Turner TH, Hibbeln JR, Pregulman M, Newman J, Johnson KB, Malek AM, Malcolm RJ, Burbelo GA, Wissman JW. Design and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3 study). Contemp Clin Trials Commun. 2019 Sep; 15:100359. PMID: 31080908.
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    7. Jones JL, Mateus CF, Malcolm RJ, Brady KT, Back SE. Efficacy of Ketamine in the Treatment of Substance Use Disorders: A Systematic Review. Front Psychiatry. 2018; 9:277. PMID: 30140240.
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    8. Marek RJ, Coulon SM, Brown JD, Lydecker JA, Marek S, Malcolm R, O'Neil PM. Characteristics of Weight Loss Trajectories in a Comprehensive Lifestyle Intervention. Obesity (Silver Spring). 2017 12; 25(12):2062-2067. PMID: 29086487.
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    9. Sahlem GL, Baker NL, George MS, Malcolm RJ, McRae-Clark AL. Repetitive transcranial magnetic stimulation (rTMS) administration to heavy cannabis users. Am J Drug Alcohol Abuse. 2018; 44(1):47-55. PMID: 28806104.
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    10. Zhu HJ, Patrick KS, Straughn AB, Reeves OT, Bernstein H, Shi J, Johnson HJ, Knight JM, Smith AT, Malcolm RJ, Markowitz JS. Ethanol Interactions With Dexmethylphenidate and dl-Methylphenidate Spheroidal Oral Drug Absorption Systems in Healthy Volunteers. J Clin Psychopharmacol. 2017 Aug; 37(4):419-428. PMID: 28590363.
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    11. Holland-Carter L, Tuerk PW, Wadden TA, Fujioka KN, Becker LE, Miller-Kovach K, Hollander PL, Garvey WT, Weiss D, Rubino DM, Kushner RF, Malcolm RJ, Raum WJ, Hermayer KL, Veliko JL, Rost SL, Sora ND, Salyer JL, O'Neil PM. Impact on psychosocial outcomes of a nationally available weight management program tailored for individuals with type 2 diabetes: Results of a randomized controlled trial. J Diabetes Complications. 2017 May; 31(5):891-897. PMID: 28319001.
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    12. Babalonis S, Haney M, Malcolm RJ, Lofwall MR, Votaw VR, Sparenborg S, Walsh SL. Oral cannabidiol does not produce a signal for abuse liability in frequent marijuana smokers. Drug Alcohol Depend. 2017 Mar 01; 172:9-13. PMID: 28088032.
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    13. O'Neil PM, Miller-Kovach K, Tuerk PW, Becker LE, Wadden TA, Fujioka K, Hollander PL, Kushner RF, Timothy Garvey W, Rubino DM, Malcolm RJ, Weiss D, Raum WJ, Salyer JL, Hermayer KL, Rost SL, Veliko JL, Sora ND. Randomized controlled trial of a nationally available weight control program tailored for adults with type 2 diabetes. Obesity (Silver Spring). 2016 11; 24(11):2269-2277. PMID: 27804264.
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    14. Back SE, McCauley JL, Korte KJ, Gros DF, Leavitt V, Gray KM, Hamner MB, DeSantis SM, Malcolm R, Brady KT, Kalivas PW. A Double-Blind, Randomized, Controlled Pilot Trial of N-Acetylcysteine in Veterans With Posttraumatic Stress Disorder and Substance Use Disorders. J Clin Psychiatry. 2016 Nov; 77(11):e1439-e1446. PMID: 27736051.
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    15. Brown JD, Buscemi J, Milsom V, Malcolm R, O'Neil PM. Effects on cardiovascular risk factors of weight losses limited to 5-10. Transl Behav Med. 2016 09; 6(3):339-46. PMID: 27528523.
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    16. Mariani JJ, Malcolm RJ, Mamczur AK, Choi JC, Brady R, Nunes E, Levin FR. Pilot trial of gabapentin for the treatment of benzodiazepine abuse or dependence in methadone maintenance patients. Am J Drug Alcohol Abuse. 2016 05; 42(3):333-40. PMID: 26962719.
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    17. Malcolm R, Myrick H, Li X, Henderson S, Brady KT, George MS, See RE. Regional Brain Activity in Abstinent Methamphetamine Dependent Males Following Cue Exposure. J Drug Abuse. 2016; 2(1). PMID: 27314105.
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    18. Haney M, Malcolm RJ, Babalonis S, Nuzzo PA, Cooper ZD, Bedi G, Gray KM, McRae-Clark A, Lofwall MR, Sparenborg S, Walsh SL. Oral Cannabidiol does not Alter the Subjective, Reinforcing or Cardiovascular Effects of Smoked Cannabis. Neuropsychopharmacology. 2016 07; 41(8):1974-82. PMID: 26708108.
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    19. Patrick KS, Straughn AB, Reeves OT, Bernstein H, Malcolm R. Comparative Ethanol-Induced Potentiation of Stimulatory Responses to Dexmethylphenidate Versus Methylphenidate. J Clin Psychopharmacol. 2015 Aug; 35(4):464-7. PMID: 26075488.
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    20. Madan A, Borckardt JJ, Balliet WE, Barth KS, Delustro LM, Malcolm RM, Koch D, Willner I, Baliga P, Reuben A. Neurocognitive status is associated with all-cause mortality among psychiatric, high-risk liver transplant candidates and recipients. Int J Psychiatry Med. 2015; 49(4):279-95. PMID: 26078395.
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    21. Wedin S, Madan A, Correll J, Crowley N, Malcolm R, Karl Byrne T, Borckardt JJ. Emotional eating, marital status and history of physical abuse predict 2-year weight loss in weight loss surgery patients. Eat Behav. 2014 Dec; 15(4):619-24. PMID: 25241076.
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    22. Barth KS, Balliet W, Pelic CM, Madan A, Malcolm R, Adams D, Morgan K, Owczarski S, Borckardt JJ. Screening for current opioid misuse and associated risk factors among patients with chronic nonalcoholic pancreatitis pain. Pain Med. 2014 Aug; 15(8):1359-64. PMID: 24716629.
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    23. McClure EA, Gipson CD, Malcolm RJ, Kalivas PW, Gray KM. Potential role of N-acetylcysteine in the management of substance use disorders. CNS Drugs. 2014 Feb; 28(2):95-106. PMID: 24442756.
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    24. Turner TF, Nance LM, Strickland WD, Malcolm RJ, Pechon S, O'Neil PM. Dietary adherence and satisfaction with a bean-based high-fiber weight loss diet: a pilot study. ISRN Obes. 2013; 2013:915415. PMID: 24555159.
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    25. Milsom VA, Malcolm RJ, Johnson GC, Pechon SM, Gray KM, Miller-Kovach K, Rost SL, O'Neil PM. Changes in cardiovascular risk factors with participation in a 12-week weight loss trial using a commercial format. Eat Behav. 2014 Jan; 15(1):68-71. PMID: 24411753.
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    26. Theim KR, Brown JD, Juarascio AS, Malcolm RR, O'Neil PM. Relations of hedonic hunger and behavioral change to weight loss among adults in a behavioral weight loss program utilizing meal-replacement products. Behav Modif. 2013 Nov; 37(6):790-805. PMID: 24013101.
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    27. Li X, Malcolm RJ, Huebner K, Hanlon CA, Taylor JJ, Brady KT, George MS, See RE. Low frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex transiently increases cue-induced craving for methamphetamine: a preliminary study. Drug Alcohol Depend. 2013 Dec 01; 133(2):641-6. PMID: 24028801.
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    28. LaRowe SD, Kalivas PW, Nicholas JS, Randall PK, Mardikian PN, Malcolm RJ. A double-blind placebo-controlled trial of N-acetylcysteine in the treatment of cocaine dependence. Am J Addict. 2013 Sep-Oct; 22(5):443-52. PMID: 23952889.
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    29. Drobes DJ, MacQueen DA, Blank MD, Saladin ME, Malcolm RJ. Effects of intravenous nicotine on prepulse inhibition in smokers and non-smokers: relationship with familial smoking. Psychopharmacology (Berl). 2013 Sep; 229(2):285-94. PMID: 23624809.
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    30. Holes-Lewis KA, Malcolm R, O'Neil PM, Hermayer K. Pharmacotherapy of obesity: clinical treatments and considerations. Am J Med Sci. 2013 Apr; 345(4):284-288. PMID: 23531960.
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    31. Madan A, Barth KS, Balliet WE, Hernandez-Tejada MA, Borckardt JJ, Malcolm R, Willner I, Koch D, Reuben A. Chronic pain among liver transplant candidates. Prog Transplant. 2012 Dec; 22(4):379-84. PMID: 23187056.
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    32. Balliet WE, Edwards-Hampton S, Borckardt JJ, Morgan K, Adams D, Owczarski S, Madan A, Galloway SK, Serber ER, Malcolm R. Depressive Symptoms, Pain, and Quality of Life among Patients with Nonalcohol-Related Chronic Pancreatitis. Pain Res Treat. 2012; 2012:978646. PMID: 23227332.
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    33. Galloway SK, Baker M, Giglio P, Chin S, Madan A, Malcolm R, Serber ER, Wedin S, Balliet W, Borckardt J. Depression and Anxiety Symptoms Relate to Distinct Components of Pain Experience among Patients with Breast Cancer. Pain Res Treat. 2012; 2012:851276. PMID: 23227331.
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    34. Patrick KS, Straughn AB, Reeves OT, Bernstein H, Bell GH, Anderson ER, Malcolm RJ. Differential influences of ethanol on early exposure to racemic methylphenidate compared with dexmethylphenidate in humans. Drug Metab Dispos. 2013 Jan; 41(1):197-205. PMID: 23104969.
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    35. Pacek LR, Malcolm RJ, Martins SS. Race/ethnicity differences between alcohol, marijuana, and co-occurring alcohol and marijuana use disorders and their association with public health and social problems using a national sample. Am J Addict. 2012 Sep-Oct; 21(5):435-44. PMID: 22882394.
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    36. Ball S, Drayton S, Robert S, Hahn N, Nappi J, Egede LE, Moran WP, Dickson M, Mauldin PD, Malcolm R. Physician acceptance of academic detailing for schizophrenia among South Carolina Medicaid providers. J S C Med Assoc. 2012 Aug; 108(4):100-2. PMID: 23270103.
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    37. Jardin BF, Larowe SD, Hall BJ, Malcolm RJ. The Obsessive Compulsive Cocaine Scale: assessment of factor structure, reliability, and validity. Addict Behav. 2011 Dec; 36(12):1223-7. PMID: 21862227.
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    38. Olive MF, Cleva RM, Kalivas PW, Malcolm RJ. Glutamatergic medications for the treatment of drug and behavioral addictions. Pharmacol Biochem Behav. 2012 Feb; 100(4):801-10. PMID: 21536062.
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    39. Borckardt JJ, Madan A, Barth K, Galloway S, Balliet W, Cawley PJ, Pelic C, Hargett S, Rublee S, McLeod-Bryant S, Malcolm R, Uhde T. Excess health care service utilization and costs associated with underrecognition of psychiatric comorbidity in a medical/surgical inpatient setting. Qual Manag Health Care. 2011 Apr-Jun; 20(2):98-102. PMID: 21467896.
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    40. Korte JE, Hiott FB, Brady KT, Malcolm RJ, See RE. Distinctive characteristics of methamphetamine users presenting at public clinics: steep rise in South Carolina, United States, 2000-2005. Drug Alcohol Depend. 2011 May 01; 115(1-2):9-15. PMID: 21145668.
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    41. Barth KS, Malcolm RJ. Disulfiram: an old therapeutic with new applications. CNS Neurol Disord Drug Targets. 2010 Mar; 9(1):5-12. PMID: 20201810.
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    42. Tahsili-Fahadan P, Malcolm R, Aston-Jones G. Modafinil: an anti-relapse medication. Neuropsychopharmacology. 2010 Jan; 35(1):343-4. PMID: 20010710.
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    43. Schuler MS, Lechner WV, Carter RE, Malcolm R. Temporal and gender trends in concordance of urine drug screens and self-reported use in cocaine treatment studies. J Addict Med. 2009 Dec; 3(4):211-7. PMID: 20209029.
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    44. Hedden SL, Martins SS, Malcolm RJ, Floyd L, Cavanaugh CE, Latimer WW. Patterns of illegal drug use among an adult alcohol dependent population: results from the National Survey on Drug Use and Health. Drug Alcohol Depend. 2010 Jan 15; 106(2-3):119-25. PMID: 19758770.
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    45. Anton RF, Myrick H, Baros AM, Latham PK, Randall PK, Wright TM, Stewart SH, Waid R, Malcolm R. Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms. J Clin Psychopharmacol. 2009 Aug; 29(4):334-42. PMID: 19593171.
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    46. Myrick H, Malcolm R, Randall PK, Boyle E, Anton RF, Becker HC, Randall CL. A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal. Alcohol Clin Exp Res. 2009 Sep; 33(9):1582-8. PMID: 19485969.
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    47. Turner TH, LaRowe S, Horner MD, Herron J, Malcolm R. Measures of cognitive functioning as predictors of treatment outcome for cocaine dependence. J Subst Abuse Treat. 2009 Dec; 37(4):328-34. PMID: 19394790.
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    48. Knackstedt LA, LaRowe S, Mardikian P, Malcolm R, Upadhyaya H, Hedden S, Markou A, Kalivas PW. The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Biol Psychiatry. 2009 May 15; 65(10):841-5. PMID: 19103434.
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    49. Hedden SL, Malcolm RJ, Latimer WW. Differences between adult non-drug users versus alcohol, cocaine and concurrent alcohol and cocaine problem users. Addict Behav. 2009 Mar; 34(3):323-6. PMID: 19059733.
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    50. Lundgren JD, Malcolm R, Binks M, O'Neil PM. Remission of metabolic syndrome following a 15-week low-calorie lifestyle change program for weight loss. Int J Obes (Lond). 2009 Jan; 33(1):144-50. PMID: 19015662.
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    51. Hedden SL, Woolson RF, Carter RE, Palesch Y, Upadhyaya HP, Malcolm RJ. The impact of loss to follow-up on hypothesis tests of the treatment effect for several statistical methods in substance abuse clinical trials. J Subst Abuse Treat. 2009 Jul; 37(1):54-63. PMID: 19008067.
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    52. Malcolm R, Olive MF, Lechner W. The safety of disulfiram for the treatment of alcohol and cocaine dependence in randomized clinical trials: guidance for clinical practice. Expert Opin Drug Saf. 2008 Jul; 7(4):459-72. PMID: 18613809.
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    53. Hedden SL, Woolson RF, Malcolm RJ. A comparison of missing data methods for hypothesis tests of the treatment effect in substance abuse clinical trials: a Monte-Carlo simulation study. Subst Abuse Treat Prev Policy. 2008 Jun 03; 3:13. PMID: 18522752.
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    54. Zhu HJ, Patrick KS, Yuan HJ, Wang JS, Donovan JL, DeVane CL, Malcolm R, Johnson JA, Youngblood GL, Sweet DH, Langaee TY, Markowitz JS. Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis. Am J Hum Genet. 2008 Jun; 82(6):1241-8. PMID: 18485328.
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    55. Shibley HL, Malcolm RJ, Veatch LM. Adolescents with insomnia and substance abuse: consequences and comorbidities. J Psychiatr Pract. 2008 May; 14(3):146-53. PMID: 18520783.
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    56. LaRowe SD, Myrick H, Hedden S, Mardikian P, Saladin M, McRae A, Brady K, Kalivas PW, Malcolm R. Is cocaine desire reduced by N-acetylcysteine? Am J Psychiatry. 2007 Jul; 164(7):1115-7. PMID: 17606664.
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    57. Gerrard P, Malcolm R. Mechanisms of modafinil: A review of current research. Neuropsychiatr Dis Treat. 2007 Jun; 3(3):349-64. PMID: 19300566.
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    58. Book SW, Myrick H, Malcolm R, Strain EC. Buprenorphine for postoperative pain following general surgery in a buprenorphine-maintained patient. Am J Psychiatry. 2007 Jun; 164(6):979. PMID: 17541066.
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    59. Nguyen SA, Malcolm R, Middaugh LD. Topiramate reduces ethanol consumption by C57BL/6 mice. Synapse. 2007 Mar; 61(3):150-6. PMID: 17146766.
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    60. Patrick KS, Straughn AB, Minhinnett RR, Yeatts SD, Herrin AE, DeVane CL, Malcolm R, Janis GC, Markowitz JS. Influence of ethanol and gender on methylphenidate pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 2007 Mar; 81(3):346-53. PMID: 17339864.
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    61. Wright TM, Myrick H, Malcolm R, Randall P, Boyle E, Henderson S, Anton R. Impact of lifetime alcohol quit attempts and medicated detoxifications on time to relapse during an index alcohol detoxification. J Addict Med. 2007 Mar; 1(1):15-20. PMID: 21768927.
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    62. Malcolm R, Myrick LH, Veatch LM, Boyle E, Randall PK. Self-reported sleep, sleepiness, and repeated alcohol withdrawals: a randomized, double blind, controlled comparison of lorazepam vs gabapentin. J Clin Sleep Med. 2007 Feb 15; 3(1):24-32. PMID: 17557449.
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    63. Mabry PL, Tooze JA, Moser RP, Augustson EM, Malcolm RJ, Benowitz NL. Nicotine, cotinine, withdrawal, and craving patterns during smoking and nicotine nasal spray use: results from a pilot study with African American men. Nicotine Tob Res. 2007 Jan; 9(1):65-82. PMID: 17365738.
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    64. McRae AL, Hedden SL, Malcolm RJ, Carter RE, Brady KT. Characteristics of cocaine- and marijuana-dependent subjects presenting for medication treatment trials. Addict Behav. 2007 Jul; 32(7):1433-40. PMID: 17150310.
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    65. Mardikian PN, LaRowe SD, Hedden S, Kalivas PW, Malcolm RJ. An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: a pilot study. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30; 31(2):389-94. PMID: 17113207.
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    66. Wright T, Myrick H, Henderson S, Peters H, Malcolm R. Risk factors for delirium tremens: a retrospective chart review. Am J Addict. 2006 May-Jun; 15(3):213-9. PMID: 16923667.
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    67. Ait-Daoud N, Malcolm RJ, Johnson BA. An overview of medications for the treatment of alcohol withdrawal and alcohol dependence with an emphasis on the use of older and newer anticonvulsants. Addict Behav. 2006 Sep; 31(9):1628-49. PMID: 16472931.
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    68. Hedden SL, Woolson RF, Malcolm RJ. Randomization in substance abuse clinical trials. Subst Abuse Treat Prev Policy. 2006 Feb 06; 1:6. PMID: 16722591.
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    69. Markowitz JS, DeVane CL, Malcolm RJ, Gefroh HA, Wang JS, Zhu HJ, Donovan JL. Pharmacokinetics of olanzapine after single-dose oral administration of standard tablet versus normal and sublingual administration of an orally disintegrating tablet in normal volunteers. J Clin Pharmacol. 2006 Feb; 46(2):164-71. PMID: 16432268.
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    70. Malcolm R, Swayngim K, Donovan JL, DeVane CL, Elkashef A, Chiang N, Khan R, Mojsiak J, Myrick DL, Hedden S, Cochran K, Woolson RF. Modafinil and cocaine interactions. Am J Drug Alcohol Abuse. 2006; 32(4):577-87. PMID: 17127546.
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    71. LaRowe SD, Mardikian P, Malcolm R, Myrick H, Kalivas P, McFarland K, Saladin M, McRae A, Brady K. Safety and tolerability of N-acetylcysteine in cocaine-dependent individuals. Am J Addict. 2006 Jan-Feb; 15(1):105-10. PMID: 16449100.
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    72. Myrick H, Taylor B, LaRowe S, Nguyen S, Boyle E, Cochran K, Malcolm R. A retrospective chart review comparing tiagabine and benzodiazepines for the treatment of alcohol withdrawal. J Psychoactive Drugs. 2005 Dec; 37(4):409-14. PMID: 16480168.
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    73. Nguyen SA, Deleon CP, Malcolm RJ, Middaugh LD. Tiagabine reduces ethanol reward in C57BL/6 mice under acute and chronic administration regimens. Synapse. 2005 Jun 01; 56(3):135-46. PMID: 15765538.
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    74. Malcolm R, LaRowe S, Cochran K, Moak D, Herron J, Brady K, Hedden S, Woolson R, Halushka P. A controlled trial of amlodipine for cocaine dependence: a negative report. J Subst Abuse Treat. 2005 Mar; 28(2):197-204. PMID: 15780550.
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    75. Donovan JL, DeVane CL, Malcolm RJ, Mojsiak J, Chiang CN, Elkashef A, Taylor RM. Modafinil influences the pharmacokinetics of intravenous cocaine in healthy cocaine-dependent volunteers. Clin Pharmacokinet. 2005; 44(7):753-65. PMID: 15966757.
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    76. Reccoppa L, Malcolm R, Ware M. Gabapentin abuse in inmates with prior history of cocaine dependence. Am J Addict. 2004 May-Jun; 13(3):321-3. PMID: 15370954.
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    77. Myrick H, Malcolm R, Taylor B, LaRowe S. Modafinil: preclinical, clinical, and post-marketing surveillance--a review of abuse liability issues. Ann Clin Psychiatry. 2004 Apr-Jun; 16(2):101-9. PMID: 15328903.
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    78. Key JD, Marsh LD, Carter CL, Malcolm RJ, Sinha D. Family-focused smoking cessation:enhanced efficacy by the addition of partner support and group therapy. Subst Abus. 2004 Mar; 25(1):37-41. PMID: 15201110.
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    79. Duka T, Gentry J, Malcolm R, Ripley TL, Borlikova G, Stephens DN, Veatch LM, Becker HC, Crews FT. Consequences of multiple withdrawals from alcohol. Alcohol Clin Exp Res. 2004 Feb; 28(2):233-46. PMID: 15112931.
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    80. Johnson BA, Swift RM, Ait-Daoud N, DiClemente CC, Javors MA, Malcolm RJ. Development of novel pharmacotherapies for the treatment of alcohol dependence: focus on antiepileptics. Alcohol Clin Exp Res. 2004 Feb; 28(2):295-301. PMID: 15112937.
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    81. Hatsukami DK, Rennard S, Patel MK, Kotlyar M, Malcolm R, Nides MA, Dozier G, Bars MP, Jamerson BD. Effects of sustained-release bupropion among persons interested in reducing but not quitting smoking. Am J Med. 2004 Feb 01; 116(3):151-7. PMID: 14749158.
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    82. Giot L, Bader JS, Brouwer C, Chaudhuri A, Kuang B, Li Y, Hao YL, Ooi CE, Godwin B, Vitols E, Vijayadamodar G, Pochart P, Machineni H, Welsh M, Kong Y, Zerhusen B, Malcolm R, Varrone Z, Collis A, Minto M, Burgess S, McDaniel L, Stimpson E, Spriggs F, Williams J, Neurath K, Ioime N, Agee M, Voss E, Furtak K, Renzulli R, Aanensen N, Carrolla S, Bickelhaupt E, Lazovatsky Y, DaSilva A, Zhong J, Stanyon CA, Finley RL, White KP, Braverman M, Jarvie T, Gold S, Leach M, Knight J, Shimkets RA, McKenna MP, Chant J, Rothberg JM. A protein interaction map of Drosophila melanogaster. Science. 2003 Dec 05; 302(5651):1727-36. PMID: 14605208.
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    83. Pawlow LA, O'Neil PM, Malcolm RJ. Night eating syndrome: effects of brief relaxation training on stress, mood, hunger, and eating patterns. Int J Obes Relat Metab Disord. 2003 Aug; 27(8):970-8. PMID: 12861239.
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    84. Donovan JL, Malcolm RJ, Markowitz JS, DeVane CL. Chiral analysis of d- and l-modafinil in human serum: application to human pharmacokinetic studies. Ther Drug Monit. 2003 Apr; 25(2):197-202. PMID: 12657914.
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    85. Malcolm RJ. GABA systems, benzodiazepines, and substance dependence. J Clin Psychiatry. 2003; 64 Suppl 3:36-40. PMID: 12662132.
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    86. Gentry JR, Hill C, Malcolm R. New anticonvulsants: a review of applications for the management of substance abuse disorders. Ann Clin Psychiatry. 2002 Dec; 14(4):233-45. PMID: 12630659.
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    87. Malcolm R, Liao J, Michel M, Cochran K, Pye W, Yeager D, Halushka PV. Amlodipine reduces blood pressure and headache frequency in cocaine-dependent outpatients. J Psychoactive Drugs. 2002 Oct-Dec; 34(4):415-9. PMID: 12562110.
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    88. Brady KT, Sonne SC, Malcolm RJ, Randall CL, Dansky BS, Simpson K, Roberts JS, Brondino M. Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorder. Exp Clin Psychopharmacol. 2002 Aug; 10(3):276-85. PMID: 12233988.
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    89. Malcolm R, Myrick H, Roberts J, Wang W, Anton RF, Ballenger JC. The effects of carbamazepine and lorazepam on single versus multiple previous alcohol withdrawals in an outpatient randomized trial. J Gen Intern Med. 2002 May; 17(5):349-55. PMID: 12047731.
      Citations:    
    90. Cochrane C, Malcolm R. Case report of abuse of Orlistat. Eat Behav. 2002; 3(2):167-9. PMID: 15001013.
      Citations:    
    91. Malcolm R, Book SW, Moak D, DeVane L, Czepowicz V. Clinical applications of modafinil in stimulant abusers: low abuse potential. Am J Addict. 2002; 11(3):247-9. PMID: 12202017.
      Citations:    
    92. Malcolm R, Myrick H, Roberts J, Wang W, Anton RF. The differential effects of medication on mood, sleep disturbance, and work ability in outpatient alcohol detoxification. Am J Addict. 2002; 11(2):141-50. PMID: 12028744.
      Citations:    
    93. Myrick H, Henderson S, Brady KT, Malcom R, Measom M. Divalproex loading in the treatment of cocaine dependence. J Psychoactive Drugs. 2001 Jul-Sep; 33(3):283-7. PMID: 11718321.
      Citations:    
    94. Myrick H, Malcolm R, Henderson S, McCormick K. Gabapentin for misuse of homemade nicotine nasal spray. Am J Psychiatry. 2001 Mar; 158(3):498. PMID: 11230002.
      Citations:    
    95. Anton RF, Moak DH, Latham PK, Waid LR, Malcolm RJ, Dias JK, Roberts JS. Posttreatment results of combining naltrexone with cognitive-behavior therapy for the treatment of alcoholism. J Clin Psychopharmacol. 2001 Feb; 21(1):72-7. PMID: 11199951.
      Citations:    
    96. Upadhyaya HP, Brady KT, Sethuraman G, Sonne SC, Malcolm R. Venlafaxine treatment of patients with comorbid alcohol/cocaine abuse and attention-deficit/hyperactivity disorder: a pilot study. J Clin Psychopharmacol. 2001 Feb; 21(1):116-8. PMID: 11199938.
      Citations:    
    97. Malcolm R, Herron J, Sutherland SE, Brady KT. Adverse outcomes in a controlled trial of pergolide for cocaine dependence. J Addict Dis. 2001; 20(1):81-92. PMID: 11286433.
      Citations:    
    98. Myrick H, Henderson S, Brady KT, Malcolm R. Gabapentin in the treatment of cocaine dependence: a case series. J Clin Psychiatry. 2001 Jan; 62(1):19-23. PMID: 11235923.
      Citations:    
    99. Malcolm R, Myrick H, Brady KT, Ballenger JC. Update on anticonvulsants for the treatment of alcohol withdrawal. Am J Addict. 2001; 10(s1):s16-s23. PMID: 11268817.
      Citations:    
    100. Myrick H, Brady KT, Malcolm R. New developments in the pharmacotherapy of alcohol dependence. Am J Addict. 2001; 10(s1):s3-s15. PMID: 11268820.
      Citations:    
    101. Malcolm R, Roberts JS, Wang W, Myrick H, Anton RF. Multiple previous detoxifications are associated with less responsive treatment and heavier drinking during an index outpatient detoxification. Alcohol. 2000 Nov; 22(3):159-64. PMID: 11163123.
      Citations:    
    102. Malcolm R, Kajdasz DK, Herron J, Anton RF, Brady KT. A double-blind, placebo-controlled outpatient trial of pergolide for cocaine dependence. Drug Alcohol Depend. 2000 Aug 01; 60(2):161-8. PMID: 10940543.
      Citations:    
    103. Myrick H, Brady KT, Malcolm R. Divalproex in the treatment of alcohol withdrawal. Am J Drug Alcohol Abuse. 2000 Feb; 26(1):155-60. PMID: 10718170.
      Citations:    
    104. Malcolm R, Herron JE, Anton RF, Roberts J, Moore J. Recurrent detoxification may elevate alcohol craving as measured by the Obsessive Compulsive Drinking scale. Alcohol. 2000 Feb; 20(2):181-5. PMID: 10719797.
      Citations:    
    105. Kajdasz DK, Moore JW, Donepudi H, Cochrane CE, Malcolm RJ. Cardiac and mood-related changes during short-term abstinence from crack cocaine: the identification of possible withdrawal phenomena. Am J Drug Alcohol Abuse. 1999 Nov; 25(4):629-37. PMID: 10548439.
      Citations:    
    106. Anton RF, Moak DH, Waid LR, Latham PK, Malcolm RJ, Dias JK. Naltrexone and cognitive behavioral therapy for the treatment of outpatient alcoholics: results of a placebo-controlled trial. Am J Psychiatry. 1999 Nov; 156(11):1758-64. PMID: 10553740.
      Citations:    
    107. George MS, Teneb├Ąck CC, Malcolm RJ, Moore J, Stallings LE, Spicer KM, Anton RF, Ballenger JC. Multiple previous alcohol detoxifications are associated with decreased medial temporal and paralimbic function in the postwithdrawal period. Alcohol Clin Exp Res. 1999 Jun; 23(6):1077-84. PMID: 10397294.
      Citations:    
    108. Malcolm R, Brady KT, Moore J, Kajdasz D. Amlodipine treatment of cocaine dependence. J Psychoactive Drugs. 1999 Apr-Jun; 31(2):117-20. PMID: 10437993.
      Citations:    
    109. Malcolm R, Anton RF, Conrad SE, Sutherland S. Carbohydrate-deficient transferrin and alcohol use in medical examiner cases. Alcohol. 1999 Jan; 17(1):7-11. PMID: 9895031.
      Citations:    
    110. Myrick H, Malcolm R, Brady KT. Gabapentin treatment of alcohol withdrawal. Am J Psychiatry. 1998 Nov; 155(11):1632. PMID: 9812141.
      Citations:    
    111. Cochrane C, Malcolm R, Brewerton T. The role of weight control as a motivation for cocaine abuse. Addict Behav. 1998 Mar-Apr; 23(2):201-7. PMID: 9573424.
      Citations:    
    112. Malcolm R, Moore JW, Kajdasz DK, Cochrane CE. Pergolide mesylate. Adverse events occurring in the treatment of cocaine dependence. Am J Addict. 1997; 6(2):117-23. PMID: 9134073.
      Citations:    
    113. Sonne S, Rubey R, Brady K, Malcolm R, Morris T. Naltrexone treatment of self-injurious thoughts and behaviors. J Nerv Ment Dis. 1996 Mar; 184(3):192-5. PMID: 8600226.
      Citations:    
    114. Thevos AK, Brown JM, Malcolm R, Randall CL. Alcohol treatment: measurement of effectiveness by global outcome. Soc Work Health Care. 1996; 23(3):57-71. PMID: 8865515.
      Citations:    
    115. Brady KT, Sonne S, Randall CL, Adinoff B, Malcolm R. Features of cocaine dependence with concurrent alcohol abuse. Drug Alcohol Depend. 1995 Jul; 39(1):69-71. PMID: 7587977.
      Citations:    
    116. Roberts JM, Malcolm R, Santos AB. Treatment of panic disorder and comorbid substance abuse with divalproex sodium. Am J Psychiatry. 1994 Oct; 151(10):1521. PMID: 8092347.
      Citations:    
    117. Malcolm R, Brady KT, Johnston AL, Cunningham M. Types of benzodiazepines abused by chemically dependent inpatients. J Psychoactive Drugs. 1993 Oct-Dec; 25(4):315-9. PMID: 7907366.
      Citations:    
    118. Malcolm R, Anton RF, Randall CL, Johnston A, Brady K, Thevos A. A placebo-controlled trial of buspirone in anxious inpatient alcoholics. Alcohol Clin Exp Res. 1992 Dec; 16(6):1007-13. PMID: 1335217.
      Citations:    
    119. Malcolm R. Disulfiram and alcoholism treatment. Am Fam Physician. 1992 Apr; 45(4):1544, 1547-8. PMID: 1558034.
      Citations:    
    120. Brady KT, Lydiard RB, Malcolm R, Ballenger JC. Cocaine-induced psychosis. J Clin Psychiatry. 1991 Dec; 52(12):509-12. PMID: 1752853.
      Citations:    
    121. Thevos AK, Johnston AL, Latham PK, Randall CL, Adinoff B, Malcolm R. Symptoms of anxiety in inpatient alcoholics with and without DSM-III-R anxiety diagnoses. Alcohol Clin Exp Res. 1991 Feb; 15(1):102-5. PMID: 2024720.
      Citations:    
    122. Malcolm R, Hutto BR, Phillips JD, Ballenger JC. Pergolide mesylate treatment of cocaine withdrawal. J Clin Psychiatry. 1991 Jan; 52(1):39-40. PMID: 1988417.
      Citations:    
    123. Brady KT, Johnston AL, Cunningham M, Malcolm R. Profiles of hospitalized benzodiazepine abusers. J Psychoactive Drugs. 1991 Jan-Mar; 23(1):71-2. PMID: 1682433.
      Citations:    
    124. Brady K, Casto S, Lydiard RB, Malcolm R, Arana G. Substance abuse in an inpatient psychiatric sample. Am J Drug Alcohol Abuse. 1991; 17(4):389-97. PMID: 1746501.
      Citations:    
    125. Malcolm R. A piece of my mind. Little battles. JAMA. 1990 Jan 05; 263(1):90. PMID: 2293694.
      Citations:    
    126. Schlesier-Carter B, Hamilton SA, O'Neil PM, Lydiard RB, Malcolm R. Depression and bulimia: the link between depression and bulimic cognitions. J Abnorm Psychol. 1989 Aug; 98(3):322-5. PMID: 2768669.
      Citations:    
    127. Malcolm R, Ballenger JC, Sturgis ET, Anton R. Double-blind controlled trial comparing carbamazepine to oxazepam treatment of alcohol withdrawal. Am J Psychiatry. 1989 May; 146(5):617-21. PMID: 2653057.
      Citations:    
    128. George MS, Scott T, Kellner CH, Malcolm R. Abnormalities of the septum pellucidum in schizophrenia. J Neuropsychiatry Clin Neurosci. 1989; 1(4):385-90. PMID: 2521087.
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    129. Malatesta VJ, West BL, Malcolm RJ. Application of behavioral principles in the management of suffocation phobia: a case study of chronic respiratory failure. Int J Psychiatry Med. 1989; 19(3):281-9. PMID: 2807746.
      Citations:    
    130. Malcolm R, Gabel T, Morton A. More on idiosyncratic reaction to naltrexone. Am J Psychiatry. 1989 Jan; 146(1):124-5. PMID: 2912237.
      Citations:    
    131. Russ NW, Sturgis ET, Malcolm RJ, Williams L. Abuse of caffeine in substance abusers. J Clin Psychiatry. 1988 Nov; 49(11):457. PMID: 3182740.
      Citations:    
    132. Malcolm R, Gabel T, Morton A. Idiosyncratic reaction to naltrexone augmented by thioridazine. Am J Psychiatry. 1988 Jun; 145(6):773-4. PMID: 3369583.
      Citations:    
    133. Malcolm R, Von JM, O'Neil PM, Currey HS, Sexauer JD, Riddle E. Update on the management of obesity. South Med J. 1988 May; 81(5):632-9. PMID: 3285495.
      Citations:    
    134. Kellner CH, Malcolm RL. Failure of sleep deprivation to prolong seizures in ECT. Am J Psychiatry. 1988 Apr; 145(4):530. PMID: 3348459.
      Citations:    
    135. Brown ME, Anton RF, Malcolm R, Ballenger JC. Alcohol detoxification and withdrawal seizures: clinical support for a kindling hypothesis. Biol Psychiatry. 1988 Mar 01; 23(5):507-14. PMID: 3345323.
      Citations:    
    136. Treiber FA, Shaw D, Malcolm R. Acquired immune deficiency syndrome: psychological impact on health personnel. J Nerv Ment Dis. 1987 Aug; 175(8):496-9. PMID: 3625190.
      Citations:    
    137. Malcolm R, O'Neil PM, Von JM, Dickerson PC. Naltrexone and dysphoria: a double-blind placebo controlled trial. Biol Psychiatry. 1987 Jun; 22(6):710-6. PMID: 3593812.
      Citations:    
    138. Malcolm R, Currey HS, Mitchell MA, Keil JE. Silver acetate gum as a deterrent to smoking. Chest. 1986 Jul; 90(1):107-11. PMID: 3522114.
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    139. Malcolm R. Facial electromyography for the diagnosis of depression. Am J Psychiatry. 1986 Jan; 143(1):123-4. PMID: 3942273.
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    140. Pfohl DN, Allen JI, Atkinson RL, Knopman DS, Malcolm RJ, Mitchell JE, Morley JE. Naltrexone hydrochloride (Trexan): a review of serum transaminase elevations at high dosage. NIDA Res Monogr. 1986; 67:66-72. PMID: 3092099.
      Citations:    
    141. Malcolm R, O'Neil PM, Sexauer JD, Riddle FE, Currey HS, Counts C. A controlled trial of naltrexone in obese humans. Int J Obes. 1985; 9(5):347-53. PMID: 3908352.
      Citations:    
    142. Malcolm R, Gross JA. Insomnia and its treatment. When are hypnotics justified? Postgrad Med. 1984 Jul; 76(1):83-90. PMID: 6146130.
      Citations:    
    143. Cannici J, Malcolm R, Peek LA. Treatment of insomnia in cancer patients using muscle relaxation training. J Behav Ther Exp Psychiatry. 1983 Sep; 14(3):251-6. PMID: 6358270.
      Citations:    
    144. White JL, Malcolm R, Roper K, Westphal MC, Smith C. Psychosocial and developmental factors in failure to thrive: one- to three- year follow-up. J Dev Behav Pediatr. 1981 Sep; 2(3):112-4. PMID: 6168654.
      Citations:    
    145. O'Neil PM, Paine PM, Riddle FE, Currey HS, Malcolm R, Sexauer JD. Restraint and age at onset of obesity. Addict Behav. 1981; 6(2):135-8. PMID: 7270298.
      Citations:    
    146. Paine PM, O'Neil PM, Malcolm R, Sexauer JD, Currey HS. Experienced control and participation in treatment of obesity. Psychol Rep. 1980 Dec; 47(3 Pt 2):1127-34. PMID: 7220745.
      Citations:    
    147. Malcolm R, Robson JR, Vanderveen TW, O'Neil PM. Psychosocial aspects of total parenteral nutrition. Psychosomatics. 1980 Feb; 21(2):115-25. PMID: 6767261.
      Citations:    
    148. Malcolm R, O'Neil PM, Hirsch AA, Currey HS, Moskowitz G. Taste hedonics and thresholds in obesity. Int J Obes. 1980; 4(3):203-12. PMID: 7419338.
      Citations:    
    149. Wernick RL, Brantley PJ, Malcolm R. Behavioral techniques in the psychological rehabilitation of burn patients. Int J Psychiatry Med. 1980-1981; 10(2):145-50. PMID: 7419364.
      Citations:    
    150. Kyong CU, Darby CP, Malcolm RJ. Pancytopenia associated with varicella. Br J Clin Pract. 1979 Oct; 33(10):299-300. PMID: 526419.
      Citations:    
    151. O'Neil PM, Currey HS, Hirsch AA, Riddle FE, Taylor CI, Malcolm RJ, Sexauer JD. Effects of sex of subject and spouse involvement on weight loss in a behavioral treatment program: a retrospective investigation. Addict Behav. 1979; 4(2):167-77. PMID: 474266.
      Citations:    
    152. Malcolm R, Foster HK, Smith C. The problem patient as perceived by family physicians. J Fam Pract. 1977 Sep; 5(3):361-4. PMID: 903747.
      Citations:    
    153. Currey H, Malcolm R, Riddle E, Schachte M. Behavioral treatment of obesity. Limitations and results with the chronically obese. JAMA. 1977 Jun 27; 237(26):2829-31. PMID: 577247.
      Citations:    
    154. Malcolm R, Riddle E, Currey HS, Sexauer JD. Behavior modification in the management of obesity. J S C Med Assoc. 1977 May; 73(5):197-9. PMID: 268464.
      Citations:    
    155. Malcolm R, Keeler MH, Miller WC. Phencyclidine toxicity: ""animal tranquilizer'' reactions. Dis Nerv Syst. 1976 Oct; 37(10):590-2. PMID: 971648.
      Citations:    
    156. Malcolm T. Current views on the management of obesity. South Med J. 1976 Feb; 69(2):138-40. PMID: 1251230.
      Citations:    
    157. Malcolm R, Miller WC. Dimenhydrinate (Dramamine) abuse: hallucinogenic experiences with a proprietary antihistamine. Am J Psychiatry. 1972 Feb; 128(8):1012-3. PMID: 5058102.
      Citations:    
    158. Malcolm R, Bicher HI, Duncan RC, Knisely MH. Behavioral effects of erthrocyte aggregation. Microvasc Res. 1972 Jan; 4(1):94-7. PMID: 5036682.
      Citations:    
    159. Yarczower M, Wolbarsht ML, Galloway WD, Fligsten KE, Malcolm R. Visual acuity in a stumptail macaque. Science. 1966 Jun 03; 152(3727):1392-3. PMID: 4957015.
      Citations:    
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