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Antonieta Lavin

Title
InstitutionMedical University of South Carolina
DepartmentNeuroscience
AddressP.O. Box MSC 510
BSB 416D
Basic Science Building - 173 Ashley Ave.
Phone843-792-6799
Fax843-792-4423
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    Dr. Lavin’s research interest is focused on understanding the cellular mechanisms that underlie attention and working memory. In particular, her lab investigates how some types of neurotransmitters regulate the electrophysiological properties of neurons located in the frontal cortex. It is thought that dopamine and noradrenaline, by modulating cortical networks, play a role on focusing attention and working memory. Areas of research interest include synaptic electrophysiology, network activity and cortical circuitry. Techniques being employed include in vitro and in vivo electrophysiology and slice cell culture.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Oprisan SA, Clementsmith X, Tompa T, Lavin A. Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice. PLoS One. 2019; 14(10):e0223469. PMID: 31618234.
      View in: PubMed
    2. Pena-Bravo JI, Penrod R, Reichel CM, Lavin A. Methamphetamine Self-Administration Elicits Sex-Related Changes in Postsynaptic Glutamate Transmission in the Prefrontal Cortex. eNeuro. 2019 Jan-Feb; 6(1). PMID: 30693312.
      View in: PubMed
    3. Oprisan SA, Imperatore J, Helms J, Tompa T, Lavin A. Cocaine-Induced Changes in Low-Dimensional Attractors of Local Field Potentials in Optogenetic Mice. Front Comput Neurosci. 2018; 12:2. PMID: 29445337.
      View in: PubMed
    4. Pena-Bravo JI, Reichel CM, Lavin A. Abstinence from Cocaine-Induced Conditioned Place Preference Produces Discrete Changes in Glutamatergic Synapses onto Deep Layer 5/6 Neurons from Prelimbic and Infralimbic Cortices. eNeuro. 2017 Nov-Dec; 4(6). PMID: 29242822.
      View in: PubMed
    5. Mishra D, Pena-Bravo JI, Leong KC, Lavin A, Reichel CM. Methamphetamine self-administration modulates glutamate neurophysiology. Brain Struct Funct. 2017 Jul; 222(5):2031-2039. PMID: 27709300.
      View in: PubMed
    6. Becker-Krail D, Farrand AQ, Boger HA, Lavin A. Effects of fingolimod administration in a genetic model of cognitive deficits. J Neurosci Res. 2017 05; 95(5):1174-1181. PMID: 27439747.
      View in: PubMed
    7. Oprisan SA, Lynn PE, Tompa T, Lavin A. Low-dimensional attractor for neural activity from local field potentials in optogenetic mice. Front Comput Neurosci. 2015; 9:125. PMID: 26483665.
      View in: PubMed
    8. Dilgen JE, Tompa T, Saggu S, Naselaris T, Lavin A. Optogenetically evoked gamma oscillations are disturbed by cocaine administration. Front Cell Neurosci. 2013; 7:213. PMID: 24376397.
      View in: PubMed
    9. Glen WB, Horowitz B, Carlson GC, Cannon TD, Talbot K, Jentsch JD, Lavin A. Dysbindin-1 loss compromises NMDAR-dependent synaptic plasticity and contextual fear conditioning. Hippocampus. 2014 Feb; 24(2):204-13. PMID: 24446171.
      View in: PubMed
    10. Saggu S, Cannon TD, Jentsch JD, Lavin A. Potential molecular mechanisms for decreased synaptic glutamate release in dysbindin-1 mutant mice. Schizophr Res. 2013 May; 146(1-3):254-63. PMID: 23473812.
      View in: PubMed
    11. Parsegian A, Glen WB, Lavin A, See RE. Methamphetamine self-administration produces attentional set-shifting deficits and alters prefrontal cortical neurophysiology in rats. Biol Psychiatry. 2011 Feb 01; 69(3):253-9. PMID: 21051037.
      View in: PubMed
    12. Karlsgodt KH, Robleto K, Trantham-Davidson H, Jairl C, Cannon TD, Lavin A, Jentsch JD. Reduced dysbindin expression mediates N-methyl-D-aspartate receptor hypofunction and impaired working memory performance. Biol Psychiatry. 2011 Jan 01; 69(1):28-34. PMID: 21035792.
      View in: PubMed
    13. Nogueira L, Lavin A. Strong somatic stimulation differentially regulates the firing properties of prefrontal cortex neurons. Brain Res. 2010 Sep 10; 1351:57-63. PMID: 20624375.
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    14. Kroener S, Lavin A. Altered dopamine modulation of inhibition in the prefrontal cortex of cocaine-sensitized rats. Neuropsychopharmacology. 2010 Oct; 35(11):2292-304. PMID: 20664581.
      View in: PubMed
    15. Jentsch JD, Trantham-Davidson H, Jairl C, Tinsley M, Cannon TD, Lavin A. Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice. Neuropsychopharmacology. 2009 Nov; 34(12):2601-8. PMID: 19641486.
      View in: PubMed
    16. Moussawi K, Pacchioni A, Moran M, Olive MF, Gass JT, Lavin A, Kalivas PW. N-Acetylcysteine reverses cocaine-induced metaplasticity. Nat Neurosci. 2009 Feb; 12(2):182-9. PMID: 19136971.
      View in: PubMed
    17. Carr DB, Andrews GD, Glen WB, Lavin A. alpha2-Noradrenergic receptors activation enhances excitability and synaptic integration in rat prefrontal cortex pyramidal neurons via inhibition of HCN currents. J Physiol. 2007 Oct 15; 584(Pt 2):437-50. PMID: 17702809.
      View in: PubMed
    18. Nogueira L, Kalivas PW, Lavin A. Long-term neuroadaptations produced by withdrawal from repeated cocaine treatment: role of dopaminergic receptors in modulating cortical excitability. J Neurosci. 2006 Nov 22; 26(47):12308-13. PMID: 17122056.
      View in: PubMed
    19. Lapish CC, Kroener S, Durstewitz D, Lavin A, Seamans JK. The ability of the mesocortical dopamine system to operate in distinct temporal modes. Psychopharmacology (Berl). 2007 Apr; 191(3):609-25. PMID: 17086392.
      View in: PubMed
    20. Andrews GD, Lavin A. Methylphenidate increases cortical excitability via activation of alpha-2 noradrenergic receptors. Neuropsychopharmacology. 2006 Mar; 31(3):594-601. PMID: 15999146.
      View in: PubMed
    21. Lavin A, Moore HM, Grace AA. Prenatal disruption of neocortical development alters prefrontal cortical neuron responses to dopamine in adult rats. Neuropsychopharmacology. 2005 Aug; 30(8):1426-35. PMID: 15827574.
      View in: PubMed
    22. Lavin A, Nogueira L, Lapish CC, Wightman RM, Phillips PE, Seamans JK. Mesocortical dopamine neurons operate in distinct temporal domains using multimodal signaling. J Neurosci. 2005 May 18; 25(20):5013-23. PMID: 15901782.
      View in: PubMed
    23. Trantham-Davidson H, Neely LC, Lavin A, Seamans JK. Mechanisms underlying differential D1 versus D2 dopamine receptor regulation of inhibition in prefrontal cortex. J Neurosci. 2004 Nov 24; 24(47):10652-9. PMID: 15564581.
      View in: PubMed
    24. Trantham-Davidson H, Lavin A. Acute cocaine administration depresses cortical activity. Neuropsychopharmacology. 2004 Nov; 29(11):2046-51. PMID: 15138440.
      View in: PubMed
    25. Lavin A. Glutamate/monoamine interactions in the limbic thalamus. Ann N Y Acad Sci. 2003 Nov; 1003:422-5. PMID: 14684478.
      View in: PubMed
    26. Seamans JK, Nogueira L, Lavin A. Synaptic basis of persistent activity in prefrontal cortex in vivo and in organotypic cultures. Cereb Cortex. 2003 Nov; 13(11):1242-50. PMID: 14576215.
      View in: PubMed
    27. Trantham H, Szumlinski KK, McFarland K, Kalivas PW, Lavin A. Repeated cocaine administration alters the electrophysiological properties of prefrontal cortical neurons. Neuroscience. 2002; 113(4):749-53. PMID: 12182882.
      View in: PubMed
    28. Turner MS, Lavin A, Grace AA, Napier TC. Regulation of limbic information outflow by the subthalamic nucleus: excitatory amino acid projections to the ventral pallidum. J Neurosci. 2001 Apr 15; 21(8):2820-32. PMID: 11306634.
      View in: PubMed
    29. Lavin A, Grace AA. Stimulation of D1-type dopamine receptors enhances excitability in prefrontal cortical pyramidal neurons in a state-dependent manner. Neuroscience. 2001; 104(2):335-46. PMID: 11377838.
      View in: PubMed
    30. Lavin A, Grace AA. Dopamine modulates the responsivity of mediodorsal thalamic cells recorded in vitro. J Neurosci. 1998 Dec 15; 18(24):10566-78. PMID: 9852593.
      View in: PubMed
    31. Lavin A, Grace AA. Response of the ventral pallidal/mediodorsal thalamic system to antipsychotic drug administration: involvement of the prefrontal cortex. Neuropsychopharmacology. 1998 May; 18(5):352-63. PMID: 9536448.
      View in: PubMed
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