Keywords
Last Name
Institution

Kristi L. Helke

Title
InstitutionMedical University of South Carolina
DepartmentComparative Medicine
AddressP.O. Box MSC 777
642
Thurmond Gazes - 30 Courtenay Drive
Phone843-876-5202
Fax843-876-5210
ORCID ORCID Icon0000-0001-9746-0764 Additional info
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Helke KL, Meyerholz DK, Beck AP, Burrough ER, Derscheid RJ, Löhr C, McInnes EF, Scudamore CL, Brayton CF. Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats. ILAR J. 2021 Mar 13. PMID: 33712827.
      View in: PubMed
    2. Wang X, Oates JC, Helke KL, Gilkeson GS, Zhang XK. Camptothecin and topotecan, inhibitors of transcription factor Fli-1 and topoisomerase, markedly ameliorate lupus nephritis in NZBWF1 mice and reduce the production of inflammatory mediators in human renal cells. Arthritis Rheumatol. 2021 Feb 08. PMID: 33559345.
      View in: PubMed
    3. Skydsgaard M, Dincer Z, Haschek WM, Helke K, Jacob B, Jacobsen B, Jeppesen G, Kato A, Kawaguchi H, McKeag S, Nelson K, Rittinghausen S, Schaudien D, Vemireddi V, Wojcinski ZW. International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Minipig. Toxicol Pathol. 2021 01; 49(1):110-228. PMID: 33393872.
      View in: PubMed
    4. Nguyen XX, Sanderson M, Helke K, Feghali-Bostwick C. Phenotypic Characterization of Transgenic Mice Expressing Human IGFBP-5. Int J Mol Sci. 2020 Dec 30; 22(1). PMID: 33396956.
      View in: PubMed
    5. Krupenko NI, Sharma J, Pediaditakis P, Helke KL, Hall MS, Du X, Sumner S, Krupenko SA. Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder. Hum Genomics. 2020 11 09; 14(1):41. PMID: 33168096.
      View in: PubMed
    6. Helke KL, Wolfe AM, Smith AC, Swagel R, Gross RH, Yao H, McCrackin MA. Mulberry Heart Disease and Hepatosis Dietetica in Farm Pigs (Sus scrofa domesticus) in a Research Setting. Comp Med. 2020 08 01; 70(4):376-383. PMID: 32674751.
      View in: PubMed
    7. Farrand AQ, Verner RS, McGuire RM, Helke KL, Hinson VK, Boger HA. Differential effects of vagus nerve stimulation paradigms guide clinical development for Parkinson's disease. Brain Stimul. 2020 Sep - Oct; 13(5):1323-1332. PMID: 32629028.
      View in: PubMed
    8. Ring HL, Gao Z, Sharma A, Han Z, Lee C, Brockbank KGM, Greene ED, Helke KL, Chen Z, Campbell LH, Weegman B, Davis M, Taylor M, Giwa S, Fahy GM, Wowk B, Pagotan R, Bischof JC, Garwood M. Imaging the distribution of iron oxide nanoparticles in hypothermic perfused tissues. Magn Reson Med. 2020 05; 83(5):1750-1759. PMID: 31815324.
      View in: PubMed
    9. Krupenko NI, Sharma J, Pediaditakis P, Fekry B, Helke KL, Du X, Sumner S, Krupenko SA. Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver. Sci Rep. 2019 10 17; 9(1):14937. PMID: 31624291.
      View in: PubMed
    10. Farrand AQ, Helke KL, Aponte-Cofresí L, Gooz MB, Gregory RA, Hinson VK, Boger HA. Effects of vagus nerve stimulation are mediated in part by TrkB in a parkinson's disease model. Behav Brain Res. 2019 11 05; 373:112080. PMID: 31301412.
      View in: PubMed
    11. Beck TC, Reichel CM, Helke KL, Bhadsavle SS, Dix TA. Non-addictive orally-active kappa opioid agonists for the treatment of peripheral pain in rats. Eur J Pharmacol. 2019 Aug 05; 856:172396. PMID: 31103632.
      View in: PubMed
    12. McDonald LT, Lopez MF, Helke KL, McCrackin MA, Cray JJ, Becker HC, LaRue AC. Early Blood Profile of C57BL/6 Mice Exposed to Chronic Unpredictable Stress. Front Psychiatry. 2019; 10:230. PMID: 31068843.
      View in: PubMed
    13. Grey ZJ, Howie RN, Durham EL, Hall SR, Helke KL, Steed MB, LaRue AC, Muise-Helmericks RC, Cray JJ. Sub-clinical dose of bone morphogenetic protein-2 does not precipitate rampant, sustained inflammatory response in bone wound healing. Wound Repair Regen. 2019 07; 27(4):335-344. PMID: 30805987.
      View in: PubMed
    14. Gross RH, Wu Y, Bonthius DJ, Gross V, Smith A, McCrackin MA, Wolfe M, Helke K, Gallien T, Yao H. Creation of a Porcine Kyphotic Model. Spine Deform. 2019 03; 7(2):213-219. PMID: 30660214.
      View in: PubMed
    15. Bredlau AL, Motamarry A, Chen C, McCrackin MA, Helke K, Armeson KE, Bynum K, Broome AM, Haemmerich D. Localized delivery of therapeutic doxorubicin dose across the canine blood-brain barrier with hyperthermia and temperature sensitive liposomes. Drug Deliv. 2018 Nov; 25(1):973-984. PMID: 29688083.
      View in: PubMed
    16. Panneer Selvam S, Roth BM, Nganga R, Kim J, Cooley MA, Helke K, Smith CD, Ogretmen B. Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3. J Biol Chem. 2018 06 22; 293(25):9784-9800. PMID: 29748384.
      View in: PubMed
    17. Steinkamp HM, Hathaway-Schrader JD, Chavez MB, Aartun JD, Zhang L, Jensen T, Shojaee Bakhtiari A, Helke KL, Stumpo DJ, Alekseyenko AV, Novince CM, Blackshear PJ, Kirkwood KL. Tristetraprolin Is Required for Alveolar Bone Homeostasis. J Dent Res. 2018 07; 97(8):946-953. PMID: 29514008.
      View in: PubMed
    18. Schutt SD, Wu Y, Tang CH, Bastian D, Nguyen H, Sofi MH, Zhang M, Liu C, Helke K, Wilson C, Schnapp LM, Del Valle JR, Hu CC, Yu XZ. Inhibition of the IRE-1a/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice. Blood Adv. 2018 02 27; 2(4):414-427. PMID: 29483082.
      View in: PubMed
    19. Helke K, Angel P, Lu P, Garrett-Mayer E, Ogretmen B, Drake R, Voelkel-Johnson C. Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis. Sci Rep. 2018 01 26; 8(1):1627. PMID: 29374263.
      View in: PubMed
    20. Killoy KM, Harlan BA, Pehar M, Helke KL, Johnson JA, Vargas MR. Decreased glutathione levels cause overt motor neuron degeneration in hSOD1WT over-expressing mice. Exp Neurol. 2018 04; 302:129-135. PMID: 29307609.
      View in: PubMed
    21. Scheffel MJ, Helke K, Lu P, Bowers JS, Ogretmen B, Garrett-Mayer E, Paulos CM, Voelkel-Johnson C. Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis. Sci Rep. 2017 Nov 14; 7(1):15552. PMID: 29138469.
      View in: PubMed
    22. Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt MW, Dhar P, Selvam SP, Fu J, Zhang J, Nguyen H, Kang I, Toth K, Al-Homrani M, Husain M, Beeson G, Ball L, Helke K, Husain S, Garrett-Mayer E, Hardiman G, Mehrotra M, Nishimura MI, Beeson CC, Bupp MG, Wu J, Ogretmen B, Paulos CM, Rathmell J, Yu XZ, Mehrotra S. CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. Cell Metab. 2018 01 09; 27(1):85-100.e8. PMID: 29129787.
      View in: PubMed
    23. Farrand AQ, Helke KL, Gregory RA, Gooz M, Hinson VK, Boger HA. Vagus nerve stimulation improves locomotion and neuronal populations in a model of Parkinson's disease. Brain Stimul. 2017 Nov - Dec; 10(6):1045-1054. PMID: 28918943.
      View in: PubMed
    24. Wada M, Canals D, Adada M, Coant N, Salama MF, Helke KL, Arthur JS, Shroyer KR, Kitatani K, Obeid LM, Hannun YA. P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment. Oncogene. 2017 11 23; 36(47):6649-6657. PMID: 28783172.
      View in: PubMed
    25. Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW. The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition. Nat Commun. 2017 05 26; 8:15503. PMID: 28548087.
      View in: PubMed
    26. Lee R, Reese C, Carmen-Lopez G, Perry B, Bonner M, Zemskova M, Wilson CL, Helke KL, Silver RM, Hoffman S, Tourkina E. Deficient Adipogenesis of Scleroderma Patient and Healthy African American Monocytes. Front Pharmacol. 2017; 8:174. PMID: 28420992.
      View in: PubMed
    27. Helke KL, McCrackin MA, Galloway AM, Poole AZ, Salgado CD, Marriott BP. Effects of antimicrobial use in agricultural animals on drug-resistant foodborne salmonellosis in humans: A systematic literature review. Crit Rev Food Sci Nutr. 2017 Feb 11; 57(3):472-488. PMID: 27602884.
      View in: PubMed
    28. McCrackin MA, Helke KL, Galloway AM, Poole AZ, Salgado CD, Marriott BP. Effect of Antimicrobial Use in Agricultural Animals on Drug-resistant Foodborne Campylobacteriosis in Humans: A Systematic Literature Review. Crit Rev Food Sci Nutr. 2016 Oct 02; 56(13):2115-32. PMID: 26580432.
      View in: PubMed
    29. Farrand AQ, Gregory RA, Bäckman CM, Helke KL, Boger HA. Altered glutamate release in the dorsal striatum of the MitoPark mouse model of Parkinson's disease. Brain Res. 2016 11 15; 1651:88-94. PMID: 27659966.
      View in: PubMed
    30. Banerjee A, Thyagarajan K, Chatterjee S, Chakraborty P, Kesarwani P, Soloshchenko M, Al-Hommrani M, Andrijauskaite K, Moxley K, Janakiraman H, Scheffel MJ, Helke K, Armenson K, Palanisamy V, Rubinstein MP, Mayer EG, Cole DJ, Paulos CM, Nishimura MI, Mehrotra S. Lack of p53 Augments Antitumor Functions in Cytolytic T Cells. Cancer Res. 2016 09 15; 76(18):5229-5240. PMID: 27466285.
      View in: PubMed
    31. Helke KL, Nelson KN, Sargeant AM, Jacob B, McKeag S, Haruna J, Vemireddi V, Greeley M, Brocksmith D, Navratil N, Stricker-Krongrad A, Hollinger C. Pigs in Toxicology: Breed Differences in Metabolism and Background Findings. Toxicol Pathol. 2016 06; 44(4):575-90. PMID: 27044377.
      View in: PubMed
    32. Bredlau AL, McCrackin MA, Motamarry A, Helke K, Chen C, Broome AM, Haemmerich D. Thermal Therapy Approaches for Treatment of Brain Tumors in Animals and Humans. Crit Rev Biomed Eng. 2016; 44(6):443-457. PMID: 29431091.
      View in: PubMed
    33. Helke KL, Nelson KN, Sargeant AM, Jacob B, McKeag S, Haruna J, Vemireddi V, Greeley M, Brocksmith D, Navratil N, Stricker-Krongrad A, Hollinger C. Background Pathological Changes in Minipigs: A Comparison of the Incidence and Nature among Different Breeds and Populations of Minipigs. Toxicol Pathol. 2016 Apr; 44(3):325-37. PMID: 26534940.
      View in: PubMed
    34. Brannick EM, DeWilde CA, Frey E, Gluckman TL, Keen JL, Larsen MR, Mont SL, Rosenbaum MD, Stafford JR, Helke KL. Taking stock and making strides toward wellness in the veterinary workplace. J Am Vet Med Assoc. 2015 Oct 01; 247(7):739-42. PMID: 26383746.
      View in: PubMed
    35. Qi X, Li G, Liu D, Motamarry A, Huang X, Wolfe AM, Helke KL, Haemmerich D, Staveley-O'Carroll KF, Kimchi ET. Development of a radiofrequency ablation platform in a clinically relevant murine model of hepatocellular cancer. . 2015; 16(12):1812-9. PMID: 26537481.
      View in: PubMed
    36. Farrand AQ, Gregory RA, Scofield MD, Helke KL, Boger HA. Effects of aging on glutamate neurotransmission in the substantia nigra of Gdnf heterozygous mice. Neurobiol Aging. 2015 Mar; 36(3):1569-76. PMID: 25577412.
      View in: PubMed
    37. Oleinik NV, Helke KL, Kistner-Griffin E, Krupenko NI, Krupenko SA. Rho GTPases RhoA and Rac1 mediate effects of dietary folate on metastatic potential of A549 cancer cells through the control of cofilin phosphorylation. J Biol Chem. 2014 Sep 19; 289(38):26383-26394. PMID: 25086046.
      View in: PubMed
    38. Zhang Y, Helke KL, Coelho SG, Valencia JC, Hearing VJ, Sun S, Liu B, Li Z. Essential role of the molecular chaperone gp96 in regulating melanogenesis. Pigment Cell Melanoma Res. 2014 Jan; 27(1):82-9. PMID: 24024552.
      View in: PubMed
    39. Helke KL, Queen SE, Mankowski JL. 14-3-3 Protein in CSF reflects SIV-mediated pre-synaptic damage. Curr HIV Res. 2013 Jun; 11(4):281-7. PMID: 24016180.
      View in: PubMed
    40. Authors of Document Swindle, M.M., Smith, A.C., Helke, K. . Recommendations for medical device implantation in swine. Source of the Document Israel Journal of Veterinary Medicine. 2013; 68(1):3-11.
    41. Helke KL, Swindle MM. Animal models of toxicology testing: the role of pigs. Expert Opin Drug Metab Toxicol. 2013 Feb; 9(2):127-39. PMID: 23216131.
      View in: PubMed
    42. Kiefer T, Hirt C, Späth C, Schüler F, Al-Ali HK, Wolf HH, Herbst R, Maschmeyer G, Helke K, Kessler C, Niederwieser D, Busemann C, Schroeder H, Vogelgesang S, Kirsch M, Montemurro M, Krüger WH, Dölken G. Long-term follow-up of high-dose chemotherapy with autologous stem-cell transplantation and response-adapted whole-brain radiotherapy for newly diagnosed primary CNS lymphoma: results of the multicenter Ostdeutsche Studiengruppe Hamatologie und Onkologie OSHO-53 phase II study. Ann Oncol. 2012 Jul; 23(7):1809-12. PMID: 22115927.
      View in: PubMed
    43. Heffernan-Stroud LA, Helke KL, Jenkins RW, De Costa AM, Hannun YA, Obeid LM. Defining a role for sphingosine kinase 1 in p53-dependent tumors. Oncogene. 2012 Mar 01; 31(9):1166-75. PMID: 21765468.
      View in: PubMed
    44. Fortress AM, Buhusi M, Helke KL, Granholm AC. Cholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats. J Aging Res. 2011; 2011:460543. PMID: 21785728.
      View in: PubMed
    45. Mack JT, Helke KL, Normand G, Green C, Townsend DM, Tew KD. ABCA2 transporter deficiency reduces incidence of TRAMP prostate tumor metastasis and cellular chemotactic migration. Cancer Lett. 2011 Jan 28; 300(2):154-61. PMID: 21041019.
      View in: PubMed
    46. Boger HA, Mannangatti P, Samuvel DJ, Saylor AJ, Bender TS, McGinty JF, Fortress AM, Zaman V, Huang P, Middaugh LD, Randall PK, Jayanthi LD, Rohrer B, Helke KL, Granholm AC, Ramamoorthy S. Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging. Genes Brain Behav. 2011 Mar; 10(2):186-98. PMID: 20860702.
      View in: PubMed
    47. Gupta RG, Kelly KM, Helke KL, Queen SE, Karper JM, Dorsey JL, Brice AK, Adams RJ, Tarwater PM, Kolson DL, Mankowski JL. HIV and SIV induce alterations in CNS CaMKII expression and activation: a potential mechanism for cognitive impairment. Am J Pathol. 2010 Jun; 176(6):2776-84. PMID: 20382699.
      View in: PubMed
    48. Schutt DJ, Swindle MM, Helke KL, Bastarrika G, Schwarz F, Haemmerich D. Sequential activation of ground pads reduces skin heating during radiofrequency tumor ablation: in vivo porcine results. IEEE Trans Biomed Eng. 2010 Mar; 57(3):746-53. PMID: 19822466.
      View in: PubMed
    49. Montemurro M, Kiefer T, Schüler F, Al-Ali HK, Wolf HH, Herbst R, Haas A, Helke K, Theilig A, Lotze C, Hirt C, Niederwieser D, Schwenke M, Krüger WH, Dölken G. Primary central nervous system lymphoma treated with high-dose methotrexate, high-dose busulfan/thiotepa, autologous stem-cell transplantation and response-adapted whole-brain radiotherapy: results of the multicenter Ostdeutsche Studiengruppe Hamato-Onkologie OSHO-53 phase II study. Ann Oncol. 2007 Apr; 18(4):665-71. PMID: 17185743.
      View in: PubMed
    50. Helke KL, Cooper TK, Mankowski JL, Poynton SL. Disseminated visceral coccidiosis in Indo-gangetic flap-shelled turtles, Lissemys punctata andersonii. J Wildl Dis. 2006 Oct; 42(4):788-96. PMID: 17255445.
      View in: PubMed
    51. Zink MC, Laast VA, Helke KL, Brice AK, Barber SA, Clements JE, Mankowski JL. From mice to macaques--animal models of HIV nervous system disease. Curr HIV Res. 2006 Jul; 4(3):293-305. PMID: 16842082.
      View in: PubMed
    52. Helke KL, Denver MC, Bronson E, Mankowski JL. Disseminate Cryptococcosis in a guenon (Cercopithecus ascanius). Vet Pathol. 2006 Jan; 43(1):75-8. PMID: 16407492.
      View in: PubMed
    53. Helke KL, Mankowski JL, Manabe YC. Animal models of cavitation in pulmonary tuberculosis. Tuberculosis (Edinb). 2006 Sep; 86(5):337-48. PMID: 16359922.
      View in: PubMed
    54. Nuermberger E, Helke K, Bishai WR. Low-dose aerosol model of pneumococcal pneumonia in the mouse: utility for evaluation of antimicrobial efficacy. Int J Antimicrob Agents. 2005 Dec; 26(6):497-503. PMID: 16289711.
      View in: PubMed
    55. Helke KL, Queen SE, Tarwater PM, Turchan-Cholewo J, Nath A, Zink MC, Irani DN, Mankowski JL. 14-3-3 protein in CSF: an early predictor of SIV CNS disease. J Neuropathol Exp Neurol. 2005 Mar; 64(3):202-8. PMID: 15804051.
      View in: PubMed
    56. Helke KL, Poynton SL. Myxidium mackiei (Myxosporea) in Indo-Gangetic flap-shelled turtles Lissemys punctata andersonii: parasite-host interaction and ultrastructure. Dis Aquat Organ. 2005 Feb 28; 63(2-3):215-30. PMID: 15819437.
      View in: PubMed
    Helke's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description