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Michael Gregory Janech

Title
InstitutionMedical University of South Carolina
DepartmentMedicine
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    Collapse Overview 
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    Acute Kidney Injury, Proton Transfer Mass Spectrometry, Proteomics, Rare Diseases, Kidney, Transplant, Urinary

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hou W, Janech MG, Sobolesky PM, Bland AM, Samsuddin S, Alazawi W, Syn WK. Proteomic screening of plasma identifies potential noninvasive biomarkers associated with significant/advanced fibrosis in patients with nonalcoholic fatty liver disease. Biosci Rep. 2020 Jan 31; 40(1). PMID: 31860081.
      View in: PubMed
    2. Zuo X, Kwon SH, Janech MG, Dang Y, Lauzon SD, Fogelgren B, Polgar N, Lipschutz JH. Primary cilia and the exocyst are linked to urinary extracellular vesicle production and content. J Biol Chem. 2019 Dec 13; 294(50):19099-19110. PMID: 31694916.
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    3. Hoard VF, Janech MG. Neurological deficits in stranded California sea lions. Vet Rec. 2019 Sep 14; 185(10):301-303. PMID: 31519846.
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    4. Arif E, Solanki AK, Srivastava P, Rahman B, Fitzgibbon WR, Deng P, Budisavljevic MN, Baicu CF, Zile MR, Megyesi J, Janech MG, Kwon SH, Collier J, Schnellmann RG, Nihalani D. Mitochondrial biogenesis induced by the ß2-adrenergic receptor agonist formoterol accelerates podocyte recovery from glomerular injury. Kidney Int. 2019 Sep; 96(3):656-673. PMID: 31262488.
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    5. Saito MA, Bertrand EM, Duffy ME, Gaylord DA, Held NA, Hervey WJ, Hettich RL, Jagtap PD, Janech MG, Kinkade DB, Leary DH, McIlvin MR, Moore EK, Morris RM, Neely BA, Nunn BL, Saunders JK, Shepherd AI, Symmonds NI, Walsh DA. Progress and Challenges in Ocean Metaproteomics and Proposed Best Practices for Data Sharing. J Proteome Res. 2019 04 05; 18(4):1461-1476. PMID: 30702898.
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    6. Arif E, Solanki AK, Srivastava P, Rahman B, Tash BR, Holzman LB, Janech MG, Martin R, Knölker HJ, Fitzgibbon WR, Deng P, Budisavljevic MN, Syn WK, Wang C, Lipschutz JH, Kwon SH, Nihalani D. The motor protein Myo1c regulates transforming growth factor-ß-signaling and fibrosis in podocytes. Kidney Int. 2019 Jul; 96(1):139-158. PMID: 31097328.
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    7. Srivastava P, Solanki AK, Arif E, Wolf BJ, Janech MG, Budisavljevic MN, Kwon SH, Nihalani D. Development of a novel cell-based assay to diagnose recurrent focal segmental glomerulosclerosis patients. Kidney Int. 2019 03; 95(3):708-716. PMID: 30709661.
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    8. Neely BA, Prager KC, Bland AM, Fontaine C, Gulland FM, Janech MG. Proteomic Analysis of Urine from California Sea Lions ( Zalophus californianus): A Resource for Urinary Biomarker Discovery. J Proteome Res. 2018 09 07; 17(9):3281-3291. PMID: 30113852.
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    9. Solanki AK, Arif E, Morinelli T, Wilson RC, Hardiman G, Deng P, Arthur JM, Velez JC, Nihalani D, Janech MG, Budisavljevic MN. A Novel CLCN5 Mutation Associated With Focal Segmental Glomerulosclerosis and Podocyte Injury. Kidney Int Rep. 2018 Nov; 3(6):1443-1453. PMID: 30426109.
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    10. Spainhour JCG, Janech MG, Ramakrishnan V. A study of the properties of Gaussian mixture model for stable isotope standard quantification in MALDI-TOF MS. Commun Stat Simul Comput. 2019; 48(6):1637-1650. PMID: 31564765.
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    11. Sagar A, Arif E, Solanki AK, Srivastava P, Janech MG, Kim SH, Lipschutz JH, Kwon SH, Nihalani D. Targeting Neph1 and ZO-1 protein-protein interaction in podocytes prevents podocyte injury and preserves glomerular filtration function. Sci Rep. 2017 09 21; 7(1):12047. PMID: 28935902.
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    12. Beiko T, Janech MG, Alekseyenko AV, Atkinson C, Coxson HO, Barth JL, Stephenson SE, Wilson CL, Schnapp LM, Barker A, Brantly M, Sandhaus RA, Silverman EK, Stoller JK, Trapnell B, Charlie S. Serum Proteins Associated with Emphysema Progression in Severe Alpha-1 Antitrypsin Deficiency. Chronic Obstr Pulm Dis. 2017 Jul 15; 4(3):204-216. PMID: 28848932.
      View in: PubMed
    13. Velez JCQ, Arif E, Rodgers J, Hicks MP, Arthur JM, Nihalani D, Bruner ET, Budisavljevic MN, Atkinson C, Fitzgibbon WR, Janech MG. Deficiency of the Angiotensinase Aminopeptidase A Increases Susceptibility to Glomerular Injury. J Am Soc Nephrol. 2017 Jul; 28(7):2119-2132. PMID: 28202497.
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    14. Mock T, Otillar RP, Strauss J, McMullan M, Paajanen P, Schmutz J, Salamov A, Sanges R, Toseland A, Ward BJ, Allen AE, Dupont CL, Frickenhaus S, Maumus F, Veluchamy A, Wu T, Barry KW, Falciatore A, Ferrante MI, Fortunato AE, Glöckner G, Gruber A, Hipkin R, Janech MG, Kroth PG, Leese F, Lindquist EA, Lyon BR, Martin J, Mayer C, Parker M, Quesneville H, Raymond JA, Uhlig C, Valas RE, Valentin KU, Worden AZ, Armbrust EV, Clark MD, Bowler C, Green BR, Moulton V, van Oosterhout C, Grigoriev IV. Evolutionary genomics of the cold-adapted diatom Fragilariopsis cylindrus. Nature. 2017 01 26; 541(7638):536-540. PMID: 28092920.
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    15. Sobolesky P, Parry C, Boxall B, Wells R, Venn-Watson S, Janech MG. Proteomic Analysis of Non-depleted Serum Proteins from Bottlenose Dolphins Uncovers a High Vanin-1 Phenotype. Sci Rep. 2016 Sep 26; 6:33879. PMID: 27667588.
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    16. Wolf BJ, Spainhour JC, Arthur JM, Janech MG, Petri M, Oates JC. Development of Biomarker Models to Predict Outcomes in Lupus Nephritis. Arthritis Rheumatol. 2016 08; 68(8):1955-63. PMID: 26867033.
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    17. Sobolesky PM, Harrell TS, Parry C, Venn-Watson S, Janech MG. Feeding a Modified Fish Diet to Bottlenose Dolphins Leads to an Increase in Serum Adiponectin and Sphingolipids. Front Endocrinol (Lausanne). 2016; 7:33. PMID: 27148164.
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    18. Neely BA, Soper JL, Gulland FM, Bell PD, Kindy M, Arthur JM, Janech MG. Proteomic analysis of cerebrospinal fluid in California sea lions (Zalophus californianus) with domoic acid toxicosis identifies proteins associated with neurodegeneration. Proteomics. 2015 Dec; 15(23-24):4051-63. PMID: 26364553.
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    19. Janech MG, Rodgers JL, Arthur JM, Velez JC. Letter to the editor: "Concern regarding quantification of urinary nephrin by a commercially available ELISA". Am J Physiol Renal Physiol. 2015 Aug 01; 309(3):F269-70. PMID: 26357486.
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    20. Bade BC, Janech MG, Ravenel JG, Stenbit AE. Bronchobiliary Fistula Presenting With Recurrent Pneumonia and Cholelithoptysis. Am J Med Sci. 2015 Jul; 350(1):72-3. PMID: 26132519.
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    21. Neely BA, Ferrante JA, Chaves JM, Soper JL, Almeida JS, Arthur JM, Gulland FM, Janech MG. Proteomic Analysis of Plasma from California Sea Lions (Zalophus californianus) Reveals Apolipoprotein E as a Candidate Biomarker of Chronic Domoic Acid Toxicosis. PLoS One. 2014; 10(4):e0123295. PMID: 25919366.
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    22. Balasubramanian S, Janech MG, Warren GW. Alterations in Salivary Proteome following Single Twenty-Minute Session of Yogic Breathing. Evid Based Complement Alternat Med. 2015; 2015:376029. PMID: 25873979.
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    23. Spainhour JC, Janech MG, Schwacke JH, Velez JC, Ramakrishnan V. The application of Gaussian mixture models for signal quantification in MALDI-TOF mass spectrometry of peptides. PLoS One. 2014; 9(11):e111016. PMID: 25372836.
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    24. Velez JC, Janech MG, Hicks MP, Morinelli TA, Rodgers J, Self SE, Arthur JM, Fitzgibbon WR. Lack of renoprotective effect of chronic intravenous angiotensin-(1-7) or angiotensin-(2-10) in a rat model of focal segmental glomerulosclerosis. PLoS One. 2014; 9(10):e110083. PMID: 25337950.
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    25. Funk JA, Janech MG, Dillon JC, Bissler JJ, Siroky BJ, Bell PD. Characterization of renal toxicity in mice administered the marine biotoxin domoic Acid. J Am Soc Nephrol. 2014 Jun; 25(6):1187-97. PMID: 24511141.
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    26. Johnson JG, Janech MG, Van Dolah FM. Caspase-like activity during aging and cell death in the toxic dinoflagellate Karenia brevis. Harmful Algae. 2014 Jan; 31:41-53. PMID: 28040110.
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    27. Venn-Watson S, Smith CR, Stevenson S, Parry C, Daniels R, Jensen E, Cendejas V, Balmer B, Janech M, Neely BA, Wells R. Blood-Based Indicators of Insulin Resistance and Metabolic Syndrome in Bottlenose Dolphins (Tursiops truncatus). Front Endocrinol (Lausanne). 2013; 4:136. PMID: 24130551.
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    28. Neely BA, Carlin KP, Arthur JM, McFee WE, Janech MG. Ratiometric Measurements of Adiponectin by Mass Spectrometry in Bottlenose Dolphins (Tursiops truncatus) with Iron Overload Reveal an Association with Insulin Resistance and Glucagon. Front Endocrinol (Lausanne). 2013; 4:132. PMID: 24065958.
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    29. Alge JL, Karakala N, Neely BA, Janech MG, Tumlin JA, Chawla LS, Shaw AD, Arthur JM. Association of elevated urinary concentration of renin-angiotensin system components and severe AKI. Clin J Am Soc Nephrol. 2013 Dec; 8(12):2043-52. PMID: 24009222.
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    30. Arthur JM, Hill EG, Alge JL, Lewis EC, Neely BA, Janech MG, Tumlin JA, Chawla LS, Shaw AD. Evaluation of 32 urine biomarkers to predict the progression of acute kidney injury after cardiac surgery. Kidney Int. 2014 Feb; 85(2):431-8. PMID: 24005224.
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    31. An N, Janech MG, Bland AM, Lazarchick J, Arthur JM, Kang Y. Proteomic analysis of murine bone marrow niche microenvironment identifies thioredoxin as a novel agent for radioprotection and for enhancing donor cell reconstitution. Exp Hematol. 2013 Nov; 41(11):944-56. PMID: 23994289.
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    32. Alge JL, Karakala N, Neely BA, Janech MG, Velez JC, Arthur JM. Urinary angiotensinogen predicts adverse outcomes among acute kidney injury patients in the intensive care unit. Crit Care. 2013 Apr 15; 17(2):R69. PMID: 23587112.
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    33. Bhensdadia NM, Hunt KJ, Lopes-Virella MF, Michael Tucker J, Mataria MR, Alge JL, Neely BA, Janech MG, Arthur JM. Urine haptoglobin levels predict early renal functional decline in patients with type 2 diabetes. Kidney Int. 2013 Jun; 83(6):1136-43. PMID: 23536133.
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    34. Gesty-Palmer D, Yuan L, Martin B, Wood WH, Lee MH, Janech MG, Tsoi LC, Zheng WJ, Luttrell LM, Maudsley S. ß-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo. Mol Endocrinol. 2013 Feb; 27(2):296-314. PMID: 23315939.
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    35. Schwacke JH, Spainhour JC, Ierardi JL, Chaves JM, Arthur JM, Janech MG, Velez JC. Network modeling reveals steps in angiotensin peptide processing. Hypertension. 2013 Mar; 61(3):690-700. PMID: 23283355.
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    36. Alge JL, Karakala N, Neely BA, Janech MG, Tumlin JA, Chawla LS, Shaw AD, Arthur JM. Urinary angiotensinogen and risk of severe AKI. Clin J Am Soc Nephrol. 2013 Feb; 8(2):184-93. PMID: 23143504.
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    37. Ravenell RL, Kamen DL, Spence JD, Hollis BW, Fleury TJ, Janech MG, Almeida JS, Shaftman SR, Oates JC. Premature atherosclerosis is associated with hypovitaminosis D and angiotensin-converting enzyme inhibitor non-use in lupus patients. Am J Med Sci. 2012 Oct; 344(4):268-73. PMID: 22222338.
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    38. Boroujerdi AF, Lee PA, DiTullio GR, Janech MG, Vied SB, Bearden DW. Identification of isethionic acid and other small molecule metabolites of Fragilariopsis cylindrus with nuclear magnetic resonance. Anal Bioanal Chem. 2012 Aug; 404(3):777-84. PMID: 22772138.
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    39. Velez JC, Ierardi JL, Bland AM, Morinelli TA, Arthur JM, Raymond JR, Janech MG. Enzymatic processing of angiotensin peptides by human glomerular endothelial cells. Am J Physiol Renal Physiol. 2012 Jun 15; 302(12):F1583-94. PMID: 22461301.
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    40. Neely BA, Soper JL, Greig DJ, Carlin KP, Favre EG, Gulland FM, Almeida JS, Janech MG. Serum profiling by MALDI-TOF mass spectrometry as a diagnostic tool for domoic acid toxicosis in California sea lions. Proteome Sci. 2012 Mar 19; 10(1):18. PMID: 22429742.
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    41. Taylor TP, Janech MG, Slate EH, Lewis EC, Arthur JM, Oates JC. Overcoming the effects of matrix interference in the measurement of urine protein analytes. Biomark Insights. 2012; 7:1-8. PMID: 22403482.
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    42. Lyon BR, Lee PA, Bennett JM, DiTullio GR, Janech MG. Proteomic analysis of a sea-ice diatom: salinity acclimation provides new insight into the dimethylsulfoniopropionate production pathway. Plant Physiol. 2011 Dec; 157(4):1926-41. PMID: 22034629.
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    43. Kendall RT, Strungs EG, Rachidi SM, Lee MH, El-Shewy HM, Luttrell DK, Janech MG, Luttrell LM. The beta-arrestin pathway-selective type 1A angiotensin receptor (AT1A) agonist [Sar1,Ile4,Ile8]angiotensin II regulates a robust G protein-independent signaling network. J Biol Chem. 2011 Jun 03; 286(22):19880-91. PMID: 21502318.
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    44. Sas KM, Janech MG, Favre E, Arthur JM, Bell PD. Cilia movement regulates expression of the Raf-1 kinase inhibitor protein. Am J Physiol Renal Physiol. 2011 May; 300(5):F1163-70. PMID: 21345975.
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    45. Bland AM, Janech MG, Almeida JS, Arthur JM. Sources of variability among replicate samples separated by two-dimensional gel electrophoresis. J Biomol Tech. 2010 Apr; 21(1):3-8. PMID: 20357976.
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    46. Varghese SA, Powell TB, Janech MG, Budisavljevic MN, Stanislaus RC, Almeida JS, Arthur JM. Identification of diagnostic urinary biomarkers for acute kidney injury. J Investig Med. 2010 Apr; 58(4):612-20. PMID: 20224435.
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    47. Velez JC, Janech MG. A case of lactic acidosis induced by linezolid. Nat Rev Nephrol. 2010 Apr; 6(4):236-42. PMID: 20348931.
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    48. Velez JC, Ryan KJ, Harbeson CE, Bland AM, Budisavljevic MN, Arthur JM, Fitzgibbon WR, Raymond JR, Janech MG. Angiotensin I is largely converted to angiotensin (1-7) and angiotensin (2-10) by isolated rat glomeruli. Hypertension. 2009 May; 53(5):790-7. PMID: 19289651.
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    49. Raymond JA, Janech MG, Fritsen CH. NOVEL ICE-BINDING PROTEINS FROM A PSYCHROPHILIC ANTARCTIC ALGA (CHLAMYDOMONADACEAE, CHLOROPHYCEAE)(1). J Phycol. 2009 Feb; 45(1):130-6. PMID: 27033652.
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    50. Raymond JA, Janech MG. Ice-binding proteins from enoki and shiitake mushrooms. Cryobiology. 2009 Apr; 58(2):151-6. PMID: 19121299.
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    51. Nazeer K, Janech MG, Lin JJ, Ryan KJ, Arthur JM, Budisavljevic MN. Changes in protein profiles during course of experimental glomerulonephritis. Am J Physiol Renal Physiol. 2009 Jan; 296(1):F186-93. PMID: 18987115.
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    52. Arthur JM, Janech MG, Varghese SA, Almeida JS, Powell TB. Diagnostic and prognostic biomarkers in acute renal failure. Contrib Nephrol. 2008; 160:53-64. PMID: 18401161.
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    53. Velez JC, Bland AM, Arthur JM, Raymond JR, Janech MG. Characterization of renin-angiotensin system enzyme activities in cultured mouse podocytes. Am J Physiol Renal Physiol. 2007 Jul; 293(1):F398-407. PMID: 17429035.
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    54. Janech MG, Raymond JR, Arthur JM. Proteomics in renal research. Am J Physiol Renal Physiol. 2007 Feb; 292(2):F501-12. PMID: 17107941.
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    55. Bland AM, D'Eugenio LR, Dugan MA, Janech MG, Almeida JS, Zile MR, Arthur JM. Comparison of variability associated with sample preparation in two-dimensional gel electrophoresis of cardiac tissue. J Biomol Tech. 2006 Jul; 17(3):195-9. PMID: 16870710.
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    56. Janech MG, Fitzgibbon WR, Nowak MW, Miller DH, Paul RV, Ploth DW. Cloning and functional characterization of a second urea transporter from the kidney of the Atlantic stingray, Dasyatis sabina. Am J Physiol Regul Integr Comp Physiol. 2006 Sep; 291(3):R844-53. PMID: 16614049.
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    57. Janech MG, Fitzgibbon WR, Ploth DW, Lacy ER, Miller DH. Effect of low environmental salinity on plasma composition and renal function of the Atlantic stingray, a euryhaline elasmobranch. Am J Physiol Renal Physiol. 2006 Oct; 291(4):F770-80. PMID: 16609153.
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    58. Gueguen Y, Garnier J, Robert L, Lefranc MP, Mougenot I, de Lorgeril J, Janech M, Gross PS, Warr GW, Cuthbertson B, Barracco MA, Bulet P, Aumelas A, Yang Y, Bo D, Xiang J, Tassanakajon A, Piquemal D, Bachère E. PenBase, the shrimp antimicrobial peptide penaeidin database: sequence-based classification and recommended nomenclature. Dev Comp Immunol. 2006; 30(3):283-8. PMID: 15963564.
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    59. de Lorgeril J, Saulnier D, Janech MG, Gueguen Y, Bachère E. Identification of genes that are differentially expressed in hemocytes of the Pacific blue shrimp (Litopenaeus stylirostris) surviving an infection with Vibrio penaeicida. Physiol Genomics. 2005 Apr 14; 21(2):174-83. PMID: 15728333.
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    60. Raymond JA, Janech MG. Cryoprotective property of diatom ice-active substance. Cryobiology. 2003 Apr; 46(2):203-4. PMID: 12686212.
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    61. Cabrera DM, Janech MG, Morinelli TA, Miller DH. A thromboxane A(2) system in the Atlantic stingray, Dasyatis sabina. Gen Comp Endocrinol. 2003 Feb 01; 130(2):157-64. PMID: 12568793.
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    62. Janech MG, Fitzgibbon WR, Chen R, Nowak MW, Miller DH, Paul RV, Ploth DW. Molecular and functional characterization of a urea transporter from the kidney of the Atlantic stingray. Am J Physiol Renal Physiol. 2003 May; 284(5):F996-F1005. PMID: 12388386.
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    63. Janech MG, Chen R, Klein J, Nowak MW, McFee W, Paul RV, Fitzgibbon WR, Ploth DW. Molecular and functional characterization of a urea transporter from the kidney of a short-finned pilot whale. Am J Physiol Regul Integr Comp Physiol. 2002 May; 282(5):R1490-500. PMID: 11959693.
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    64. Bagnasco SM, Peng T, Janech MG, Karakashian A, Sands JM. Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene. Am J Physiol Renal Physiol. 2001 Sep; 281(3):F400-6. PMID: 11502588.
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