Julie Chao

Title
InstitutionMedical University of South Carolina
DepartmentBiochemistry and Molecular Biology
AddressP.O. Box MSC 509
518A
173 Ashley Ave.
Phone843-792-9927
Fax843-792-8568
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yiu WH, Li Y, Lok SWY, Chan KW, Chan LYY, Leung JCK, Lai KN, Tsu JHL, Chao J, Huang XR, Lan HY, Tang SCW. Protective role of kallistatin in renal fibrosis via modulation of Wnt/ß-catenin signaling. Clin Sci (Lond). 2021 Feb 12; 135(3):429-446. PMID: 33458750.
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    2. Alexander-Curtis M, Pauls R, Chao J, Volpi JJ, Bath PM, Verdoorn TA. Human tissue kallikrein in the treatment of acute ischemic stroke. Ther Adv Neurol Disord. 2019; 12:1756286418821918. PMID: 30719079.
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    3. Chao J, Guo Y, Chao L. Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation. Oxid Med Cell Longev. 2018; 2018:4138560. PMID: 30622668.
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    4. Yao Y, Li B, Liu C, Fu C, Li P, Guo Y, Ma G, Liu N, Chao L, Chao J. Reduced Plasma Kallistatin Is Associated With the Severity of Coronary Artery Disease, and Kallistatin Treatment Attenuates Atherosclerotic Plaque Formation in Mice. J Am Heart Assoc. 2018 11 06; 7(21):e009562. PMID: 30554563.
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    5. Guo Y, Chao L, Chao J. Kallistatin attenuates endothelial senescence by modulating Let-7g-mediated miR-34a-SIRT1-eNOS pathway. J Cell Mol Med. 2018 09; 22(9):4387-4398. PMID: 29992759.
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    6. Chao J, Guo Y, Li P, Chao L. Opposing Effects of Oxygen Regulation on Kallistatin Expression: Kallistatin as a Novel Mediator of Oxygen-Induced HIF-1-eNOS-NO Pathway. Oxid Med Cell Longev. 2017; 2017:5262958. PMID: 29387292.
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    7. Chao J, Li P, Chao L. Kallistatin: double-edged role in angiogenesis, apoptosis and oxidative stress. Biol Chem. 2017 11 27; 398(12):1309-1317. PMID: 28742513.
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    8. Chao J, Guo Y, Li P, Chao L. Role of Kallistatin Treatment in Aging and Cancer by Modulating miR-34a and miR-21 Expression. Oxid Med Cell Longev. 2017; 2017:5025610. PMID: 28744338.
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    9. Lin WC, Chen CW, Chao L, Chao J, Lin YS. Plasma kallistatin in critically ill patients with severe sepsis and septic shock. PLoS One. 2017; 12(5):e0178387. PMID: 28542440.
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    10. Guo Y, Li P, Gao L, Zhang J, Yang Z, Bledsoe G, Chang E, Chao L, Chao J. Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway. Aging Cell. 2017 08; 16(4):837-846. PMID: 28544111.
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    11. Chao J, Li P, Chao L. Kallistatin suppresses cancer development by multi-factorial actions. Crit Rev Oncol Hematol. 2017 May; 113:71-78. PMID: 28427524.
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    12. Chao J, Bledsoe G, Chao L. Protective Role of Kallistatin in Vascular and Organ Injury. Hypertension. 2016 09; 68(3):533-41. PMID: 27432868.
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    13. Li P, Guo Y, Bledsoe G, Yang Z, Chao L, Chao J. Kallistatin induces breast cancer cell apoptosis and autophagy by modulating Wnt signaling and microRNA synthesis. Exp Cell Res. 2016 Jan 15; 340(2):305-14. PMID: 26790955.
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    14. Lin WC, Chen CW, Huang YW, Chao L, Chao J, Lin YS, Lin CF. Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis. Sci Rep. 2015 Jul 22; 5:12463. PMID: 26198099.
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    15. Leu CH, Yang ML, Chung NH, Huang YJ, Su YC, Chen YC, Lin CC, Shieh GS, Chang MY, Wang SW, Chang Y, Chao J, Chao L, Wu CL, Shiau AL. Kallistatin ameliorates influenza virus pathogenesis by inhibition of kallikrein-related peptidase 1-mediated cleavage of viral hemagglutinin. Antimicrob Agents Chemother. 2015 Sep; 59(9):5619-30. PMID: 26149981.
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    16. Guo Y, Li P, Bledsoe G, Yang ZR, Chao L, Chao J. Kallistatin inhibits TGF-ß-induced endothelial-mesenchymal transition by differential regulation of microRNA-21 and eNOS expression. Exp Cell Res. 2015 Sep 10; 337(1):103-10. PMID: 26156753.
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    17. Li P, Guo Y, Bledsoe G, Yang ZR, Fan H, Chao L, Chao J. Kallistatin treatment attenuates lethality and organ injury in mouse models of established sepsis. Crit Care. 2015 May 01; 19:200. PMID: 25930108.
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    18. Chao J, Bledsoe G, Chao L. Kallikrein-kinin in stem cell therapy. World J Stem Cells. 2014 Sep 26; 6(4):448-57. PMID: 25258666.
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    19. Gao L, Li P, Zhang J, Hagiwara M, Shen B, Bledsoe G, Chang E, Chao L, Chao J. Novel role of kallistatin in vascular repair by promoting mobility, viability, and function of endothelial progenitor cells. J Am Heart Assoc. 2014 Sep 18; 3(5):e001194. PMID: 25237049.
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    20. Li P, Bledsoe G, Yang ZR, Fan H, Chao L, Chao J. Human kallistatin administration reduces organ injury and improves survival in a mouse model of polymicrobial sepsis. Immunology. 2014 Jun; 142(2):216-26. PMID: 24467264.
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    21. Palanisamy AP, Cheng G, Sutter AG, Liu J, Lewin DN, Chao J, Chavin K. Adenovirus-mediated eNOS expression augments liver injury after ischemia/reperfusion in mice. PLoS One. 2014; 9(3):e93304. PMID: 24667691.
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    22. Chao J, Bledsoe G, Chao L. Tissue kallikrein-kinin therapy in hypertension and organ damage. Prog Drug Res. 2014; 69:37-57. PMID: 25130039.
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    23. Lu SL, Tsai CY, Luo YH, Kuo CF, Lin WC, Chang YT, Wu JJ, Chuang WJ, Liu CC, Chao L, Chao J, Lin YS. Kallistatin modulates immune cells and confers anti-inflammatory response to protect mice from group A streptococcal infection. Antimicrob Agents Chemother. 2013 Nov; 57(11):5366-72. PMID: 23959316.
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    24. Gao L, Bledsoe G, Yin H, Shen B, Chao L, Chao J. Tissue kallikrein-modified mesenchymal stem cells provide enhanced protection against ischemic cardiac injury after myocardial infarction. Circ J. 2013; 77(8):2134-44. PMID: 23697984.
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    25. Zhang J, Yang Z, Li P, Bledsoe G, Chao L, Chao J. Kallistatin antagonizes Wnt/ß-catenin signaling and cancer cell motility via binding to low-density lipoprotein receptor-related protein 6. Mol Cell Biochem. 2013 Jul; 379(1-2):295-301. PMID: 23666756.
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    26. Yao YY, Fu C, Ma GS, Feng Y, Shen CX, Wu GQ, Zhang XG, Ding JD, Tang CC, Chen Z, Dai QM, Tong JY, Luo D, Zhu J, Zhi H, Li YJ, Ju CW, Lu J, Chao J, Chao L. Tissue kallikrein is related to the severity of coronary artery disease. Clin Chim Acta. 2013 Aug 23; 423:90-8. PMID: 23639635.
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    27. Yao Y, Sheng Z, Li Y, Fu C, Ma G, Liu N, Chao J, Chao L. Tissue kallikrein-modified human endothelial progenitor cell implantation improves cardiac function via enhanced activation of akt and increased angiogenesis. Lab Invest. 2013 May; 93(5):577-91. PMID: 23508045.
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    28. Lin WC, Lu SL, Lin CF, Chen CW, Chao L, Chao J, Lin YS. Plasma kallistatin levels in patients with severe community-acquired pneumonia. Crit Care. 2013 Feb 08; 17(1):R27. PMID: 23394256.
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    29. Liu Y, Bledsoe G, Hagiwara M, Shen B, Chao L, Chao J. Depletion of endogenous kallistatin exacerbates renal and cardiovascular oxidative stress, inflammation, and organ remodeling. Am J Physiol Renal Physiol. 2012 Oct 15; 303(8):F1230-8. PMID: 22811485.
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    30. Patel AB, Chao J, Palmer LG. Tissue kallikrein activation of the epithelial Na channel. Am J Physiol Renal Physiol. 2012 Aug 15; 303(4):F540-50. PMID: 22622459.
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    31. Yao Y, Sheng Z, Li Y, Yan F, Fu C, Li Y, Ma G, Liu N, Chao J, Chao L. Tissue kallikrein promotes cardiac neovascularization by enhancing endothelial progenitor cell functional capacity. Hum Gene Ther. 2012 Aug; 23(8):859-70. PMID: 22435954.
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    32. Zhou J, Zhang J, Chao J. Porphyromonas gingivalis promotes monocyte migration by activating MMP-9. J Periodontal Res. 2012 Apr; 47(2):236-42. PMID: 22035412.
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    33. Shen B, Gao L, Hsu YT, Bledsoe G, Hagiwara M, Chao L, Chao J. Kallistatin attenuates endothelial apoptosis through inhibition of oxidative stress and activation of Akt-eNOS signaling. . 2010 Nov; 299(5):H1419-27. PMID: 20729399.
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    34. Gao L, Smith RS, Chen LM, Chai KX, Chao L, Chao J. Tissue kallikrein promotes prostate cancer cell migration and invasion via a protease-activated receptor-1-dependent signaling pathway. Biol Chem. 2010 Jul; 391(7):803-12. PMID: 20482314.
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    35. Yin H, Gao L, Shen B, Chao L, Chao J. Kallistatin inhibits vascular inflammation by antagonizing tumor necrosis factor-alpha-induced nuclear factor kappaB activation. Hypertension. 2010 Aug; 56(2):260-7. PMID: 20566960.
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    36. Shiau AL, Teo ML, Chen SY, Wang CR, Hsieh JL, Chang MY, Chang CJ, Chao J, Chao L, Wu CL, Lee CH. Inhibition of experimental lung metastasis by systemic lentiviral delivery of kallistatin. BMC Cancer. 2010 May 31; 10:245. PMID: 20509975.
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    37. Chao J, Shen B, Gao L, Xia CF, Bledsoe G, Chao L. Tissue kallikrein in cardiovascular, cerebrovascular and renal diseases and skin wound healing. Biol Chem. 2010 Apr; 391(4):345-55. PMID: 20180644.
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    38. Liu Y, Bledsoe G, Hagiwara M, Yang ZR, Shen B, Chao L, Chao J. Blockade of endogenous tissue kallikrein aggravates renal injury by enhancing oxidative stress and inhibiting matrix degradation. Am J Physiol Renal Physiol. 2010 Apr; 298(4):F1033-40. PMID: 20089675.
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    39. Shen B, Chao L, Chao J. Pivotal role of JNK-dependent FOXO1 activation in downregulation of kallistatin expression by oxidative stress. . 2010 Mar; 298(3):H1048-54. PMID: 20081110.
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    40. Shen B, Smith RS, Hsu YT, Chao L, Chao J. Kruppel-like factor 4 is a novel mediator of Kallistatin in inhibiting endothelial inflammation via increased endothelial nitric-oxide synthase expression. J Biol Chem. 2009 Dec 18; 284(51):35471-8. PMID: 19858207.
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    41. Gao L, Chao L, Chao J. A novel signaling pathway of tissue kallikrein in promoting keratinocyte migration: activation of proteinase-activated receptor 1 and epidermal growth factor receptor. Exp Cell Res. 2010 Feb 01; 316(3):376-89. PMID: 19879874.
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    42. Smith RS, Gao L, Bledsoe G, Chao L, Chao J. Intermedin is a new angiogenic growth factor. . 2009 Sep; 297(3):H1040-7. PMID: 19592612.
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    43. Zhu H, Chao J, Guo D, Li K, Huang Y, Hawkins K, Wright N, Stallmann-Jorgensen I, Yan W, Harshfield GA, Dong Y. Urinary prostasin: a possible biomarker for renal pressure natriuresis in black adolescents. Pediatr Res. 2009 Apr; 65(4):443-6. PMID: 19127211.
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    44. Hsieh JL, Shen PC, Shiau AL, Jou IM, Lee CH, Teo ML, Wang CR, Chao J, Chao L, Wu CL. Adenovirus-mediated kallistatin gene transfer ameliorates disease progression in a rat model of osteoarthritis induced by anterior cruciate ligament transection. Hum Gene Ther. 2009 Feb; 20(2):147-58. PMID: 20377366.
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    45. Hagiwara M, Bledsoe G, Yang ZR, Smith RS, Chao L, Chao J. Intermedin ameliorates vascular and renal injury by inhibition of oxidative stress. Am J Physiol Renal Physiol. 2008 Dec; 295(6):F1735-43. PMID: 18829738.
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    46. Chao J, Yin H, Gao L, Hagiwara M, Shen B, Yang ZR, Chao L. Tissue kallikrein elicits cardioprotection by direct kinin b2 receptor activation independent of kinin formation. Hypertension. 2008 Oct; 52(4):715-20. PMID: 18768400.
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    47. Gao L, Yin H, S Smith R, Chao L, Chao J. Role of kallistatin in prevention of cardiac remodeling after chronic myocardial infarction. Lab Invest. 2008 Nov; 88(11):1157-66. PMID: 18762777.
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    48. Yao YY, Yin H, Shen B, Smith RS, Liu Y, Gao L, Chao L, Chao J. Tissue kallikrein promotes neovascularization and improves cardiac function by the Akt-glycogen synthase kinase-3beta pathway. Cardiovasc Res. 2008 Dec 01; 80(3):354-64. PMID: 18689794.
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    49. Hagiwara M, Shen B, Chao L, Chao J. Kallikrein-modified mesenchymal stem cell implantation provides enhanced protection against acute ischemic kidney injury by inhibiting apoptosis and inflammation. Hum Gene Ther. 2008 Aug; 19(8):807-19. PMID: 18554097.
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    50. Zhu H, Guo D, Li K, Yan W, Tan Y, Wang X, Treiber FA, Chao J, Snieder H, Dong Y. Prostasin: a possible candidate gene for human hypertension. Am J Hypertens. 2008 Sep; 21(9):1028-33. PMID: 18583984.
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    51. Smith RS, Gao L, Chao L, Chao J. Tissue kallikrein and kinin infusion promotes neovascularization in limb ischemia. Biol Chem. 2008 Jun; 389(6):725-30. PMID: 18627294.
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    52. Shen B, Hagiwara M, Yao YY, Chao L, Chao J. Salutary effect of kallistatin in salt-induced renal injury, inflammation, and fibrosis via antioxidative stress. Hypertension. 2008 May; 51(5):1358-65. PMID: 18391098.
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    53. Bledsoe G, Shen B, Yao YY, Hagiwara M, Mizell B, Teuton M, Grass D, Chao L, Chao J. Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury. Toxicol Sci. 2008 Apr; 102(2):433-43. PMID: 18227104.
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    54. Yin H, Chao L, Chao J. Nitric oxide mediates cardiac protection of tissue kallikrein by reducing inflammation and ventricular remodeling after myocardial ischemia/reperfusion. Life Sci. 2008 Jan 16; 82(3-4):156-65. PMID: 18068196.
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    55. Wang CR, Chen SY, Shiau AL, Wu CL, Jou IM, Chao L, Chao J. Upregulation of kallistatin expression in rheumatoid joints. J Rheumatol. 2007 Nov; 34(11):2171-6. PMID: 17937475.
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    56. Yao YY, Yin H, Shen B, Chao L, Chao J. Tissue kallikrein and kinin infusion rescues failing myocardium after myocardial infarction. J Card Fail. 2007 Sep; 13(7):588-96. PMID: 17826650.
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    57. Yin H, Chao J, Bader M, Chao L. Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling. Peptides. 2007 Jul; 28(7):1383-9. PMID: 17644219.
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    58. Yuan G, Deng J, Wang T, Zhao C, Xu X, Wang P, Voltz JW, Edin ML, Xiao X, Chao L, Chao J, Zhang XA, Zeldin DC, Wang DW. Tissue kallikrein reverses insulin resistance and attenuates nephropathy in diabetic rats by activation of phosphatidylinositol 3-kinase/protein kinase B and adenosine 5'-monophosphate-activated protein kinase signaling pathways. Endocrinology. 2007 May; 148(5):2016-26. PMID: 17272402.
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    59. Chao J, Li HJ, Yao YY, Shen B, Gao L, Bledsoe G, Chao L. Kinin infusion prevents renal inflammation, apoptosis, and fibrosis via inhibition of oxidative stress and mitogen-activated protein kinase activity. Hypertension. 2007 Mar; 49(3):490-7. PMID: 17224475.
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    60. Yao YY, Yin H, Shen B, Chao L, Chao J. Tissue kallikrein infusion prevents cardiomyocyte apoptosis, inflammation and ventricular remodeling after myocardial infarction. Regul Pept. 2007 Apr 05; 140(1-2):12-20. PMID: 17196272.
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    61. Chao J, Yin H, Yao YY, Shen B, Smith RS, Chao L. Novel role of kallistatin in protection against myocardial ischemia-reperfusion injury by preventing apoptosis and inflammation. Hum Gene Ther. 2006 Dec; 17(12):1201-13. PMID: 17081080.
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    62. Li HJ, Yin H, Yao YY, Shen B, Bader M, Chao L, Chao J. Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3beta activation. Cardiovasc Res. 2007 Jan 01; 73(1):130-42. PMID: 17137568.
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    63. Chiang WC, Chien CT, Lin WW, Lin SL, Chen YM, Lai CF, Wu KD, Chao J, Tsai TJ. Early activation of bradykinin B2 receptor aggravates reactive oxygen species generation and renal damage in ischemia/reperfusion injury. Free Radic Biol Med. 2006 Oct 15; 41(8):1304-14. PMID: 17015177.
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    64. Chao J, Bledsoe G, Yin H, Chao L. The tissue kallikrein-kinin system protects against cardiovascular and renal diseases and ischemic stroke independently of blood pressure reduction. Biol Chem. 2006 Jun; 387(6):665-75. PMID: 16800727.
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    65. Chao J, Chao L. Experimental therapy with tissue kallikrein against cerebral ischemia. Front Biosci. 2006 May 01; 11:1323-7. PMID: 16368519.
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    66. Bledsoe G, Shen B, Yao Y, Zhang JJ, Chao L, Chao J. Reversal of renal fibrosis, inflammation, and glomerular hypertrophy by kallikrein gene delivery. Hum Gene Ther. 2006 May; 17(5):545-55. PMID: 16716111.
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    67. Chen LM, Wang C, Chen M, Marcello MR, Chao J, Chao L, Chai KX. Prostasin attenuates inducible nitric oxide synthase expression in lipopolysaccharide-induced urinary bladder inflammation. Am J Physiol Renal Physiol. 2006 Sep; 291(3):F567-77. PMID: 16638913.
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    68. Xia CF, Smith RS, Shen B, Yang ZR, Borlongan CV, Chao L, Chao J. Postischemic brain injury is exacerbated in mice lacking the kinin B2 receptor. Hypertension. 2006 Apr; 47(4):752-61. PMID: 16534002.
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    69. Xia CF, Yin H, Yao YY, Borlongan CV, Chao L, Chao J. Kallikrein protects against ischemic stroke by inhibiting apoptosis and inflammation and promoting angiogenesis and neurogenesis. Hum Gene Ther. 2006 Feb; 17(2):206-19. PMID: 16454654.
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    70. Bledsoe G, Crickman S, Mao J, Xia CF, Murakami H, Chao L, Chao J. Kallikrein/kinin protects against gentamicin-induced nephrotoxicity by inhibition of inflammation and apoptosis. Nephrol Dial Transplant. 2006 Mar; 21(3):624-33. PMID: 16401625.
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    71. Xia CF, Yin H, Borlongan CV, Chao J, Chao L. Postischemic infusion of adrenomedullin protects against ischemic stroke by inhibiting apoptosis and promoting angiogenesis. Exp Neurol. 2006 Feb; 197(2):521-30. PMID: 16343485.
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    72. Xia CF, Bledsoe G, Chao L, Chao J. Kallikrein gene transfer reduces renal fibrosis, hypertrophy, and proliferation in DOCA-salt hypertensive rats. Am J Physiol Renal Physiol. 2005 Sep; 289(3):F622-31. PMID: 15886273.
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    73. Montanari D, Yin H, Dobrzynski E, Agata J, Yoshida H, Chao J, Chao L. Kallikrein gene delivery improves serum glucose and lipid profiles and cardiac function in streptozotocin-induced diabetic rats. Diabetes. 2005 May; 54(5):1573-80. PMID: 15855348.
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    74. Smith RS, Agata J, Xia CF, Chao L, Chao J. Human endothelial nitric oxide synthase gene delivery protects against cardiac remodeling and reduces oxidative stress after myocardial infarction. Life Sci. 2005 Apr 08; 76(21):2457-71. PMID: 15763077.
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    75. Wang CR, Chen SY, Wu CL, Liu MF, Jin YT, Chao L, Chao J. Prophylactic adenovirus-mediated human kallistatin gene therapy suppresses rat arthritis by inhibiting angiogenesis and inflammation. Arthritis Rheum. 2005 Apr; 52(4):1319-24. PMID: 15818689.
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    76. Chao J, Chao L. Kallikrein-kinin in stroke, cardiovascular and renal disease. Exp Physiol. 2005 May; 90(3):291-8. PMID: 15653716.
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    77. Yin H, Chao L, Chao J. Kallikrein/kinin protects against myocardial apoptosis after ischemia/reperfusion via Akt-glycogen synthase kinase-3 and Akt-Bad.14-3-3 signaling pathways. J Biol Chem. 2005 Mar 04; 280(9):8022-30. PMID: 15611141.
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    78. Xia CF, Yin H, Borlongan CV, Chao J, Chao L. Adrenomedullin gene delivery protects against cerebral ischemic injury by promoting astrocyte migration and survival. Hum Gene Ther. 2004 Dec; 15(12):1243-54. PMID: 15684700.
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    79. Zhang JJ, Bledsoe G, Kato K, Chao L, Chao J. Tissue kallikrein attenuates salt-induced renal fibrosis by inhibition of oxidative stress. Kidney Int. 2004 Aug; 66(2):722-32. PMID: 15253727.
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    80. Chen LG, Wang ZR, Wan CM, Chao L, Chao J, Xing HY. Encapsulated transgene cells attenuate hypertension, cardiac hypertrophy and enhance renal function in Goldblatt hypertensive rats. J Gene Med. 2004 Jul; 6(7):786-97. PMID: 15241786.
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    81. Porcu P, Emanueli C, Desortes E, Marongiu GM, Piredda F, Chao L, Chao J, Madeddu P. Circulating tissue kallikrein levels correlate with severity of carotid atherosclerosis. Arterioscler Thromb Vasc Biol. 2004 Jun; 24(6):1104-10. PMID: 15072994.
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    82. Xia CF, Yin H, Borlongan CV, Chao L, Chao J. Kallikrein gene transfer protects against ischemic stroke by promoting glial cell migration and inhibiting apoptosis. Hypertension. 2004 Feb; 43(2):452-9. PMID: 14698996.
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    83. Yin H, Chao L, Chao J. Adrenomedullin protects against myocardial apoptosis after ischemia/reperfusion through activation of Akt-GSK signaling. Hypertension. 2004 Jan; 43(1):109-16. PMID: 14662648.
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    84. Zhao C, Wang P, Xiao X, Chao J, Chao L, Wang DW, Zeldin DC. Gene therapy with human tissue kallikrein reduces hypertension and hyperinsulinemia in fructose-induced hypertensive rats. Hypertension. 2003 Nov; 42(5):1026-33. PMID: 14568997.
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    85. Kawasaki K, Smith RS, Hsieh CM, Sun J, Chao J, Liao JK. Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis. Mol Cell Biol. 2003 Aug; 23(16):5726-37. PMID: 12897144.
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    86. Bledsoe G, Chao L, Chao J. Kallikrein gene delivery attenuates cardiac remodeling and promotes neovascularization in spontaneously hypertensive rats. . 2003 Oct; 285(4):H1479-88. PMID: 12816755.
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    87. Kato K, Yin H, Agata J, Yoshida H, Chao L, Chao J. Adrenomedullin gene delivery attenuates myocardial infarction and apoptosis after ischemia and reperfusion. . 2003 Oct; 285(4):H1506-14. PMID: 12805025.
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    88. Miao RQ, Chen V, Chao L, Chao J. Structural elements of kallistatin required for inhibition of angiogenesis. . 2003 06; 284(6):C1604-13. PMID: 12734113.
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    89. Agata J, Zhang JJ, Chao J, Chao L. Adrenomedullin gene delivery inhibits neointima formation in rat artery after balloon angioplasty. Regul Pept. 2003 Apr 15; 112(1-3):115-20. PMID: 12667632.
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    90. Takahashi S, Suzuki S, Inaguma S, Ikeda Y, Cho YM, Hayashi N, Inoue T, Sugimura Y, Nishiyama N, Fujita T, Chao J, Ushijima T, Shirai T. Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers. Prostate. 2003 Feb 15; 54(3):187-93. PMID: 12518323.
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    91. Wang C, Chao J, Chao L. Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats. . 2003 Apr; 284(4):R1031-6. PMID: 12626364.
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    92. Dobrzynski E, Montanari D, Agata J, Zhu J, Chao J, Chao L. Adrenomedullin improves cardiac function and prevents renal damage in streptozotocin-induced diabetic rats. Am J Physiol Endocrinol Metab. 2002 Dec; 283(6):E1291-8. PMID: 12424108.
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    93. Miao RQ, Agata J, Chao L, Chao J. Kallistatin is a new inhibitor of angiogenesis and tumor growth. Blood. 2002 Nov 01; 100(9):3245-52. PMID: 12384424.
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    94. Agata J, Chao L, Chao J. Kallikrein gene delivery improves cardiac reserve and attenuates remodeling after myocardial infarction. Hypertension. 2002 Nov; 40(5):653-9. PMID: 12411458.
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    95. Ni A, Yin H, Agata J, Yang Z, Chao L, Chao J. Overexpression of kinin B1 receptors induces hypertensive response to des-Arg9-bradykinin and susceptibility to inflammation. J Biol Chem. 2003 Jan 03; 278(1):219-25. PMID: 12411434.
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    96. Emanueli C, Salis MB, Pinna A, Stacca T, Milia AF, Spano A, Chao J, Chao L, Sciola L, Madeddu P. Prevention of diabetes-induced microangiopathy by human tissue kallikrein gene transfer. Circulation. 2002 Aug 20; 106(8):993-9. PMID: 12186806.
      Citations:    
    97. Smith RS, Lin KF, Agata J, Chao L, Chao J. Human endothelial nitric oxide synthase gene delivery promotes angiogenesis in a rat model of hindlimb ischemia. Arterioscler Thromb Vasc Biol. 2002 Aug 01; 22(8):1279-85. PMID: 12171788.
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    98. Thongboonkerd V, Gozal E, Sachleben LR, Arthur JM, Pierce WM, Cai J, Chao J, Bader M, Pesquero JB, Gozal D, Klein JB. Proteomic analysis reveals alterations in the renal kallikrein pathway during hypoxia-induced hypertension. J Biol Chem. 2002 Sep 20; 277(38):34708-16. PMID: 12121987.
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    99. Yu H, Song Q, Freedman BI, Chao J, Chao L, Rich SS, Bowden DW. Association of the tissue kallikrein gene promoter with ESRD and hypertension. Kidney Int. 2002 Mar; 61(3):1030-9. PMID: 11849458.
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    100. Narikiyo T, Kitamura K, Adachi M, Miyoshi T, Iwashita K, Shiraishi N, Nonoguchi H, Chen LM, Chai KX, Chao J, Tomita K. Regulation of prostasin by aldosterone in the kidney. J Clin Invest. 2002 Feb; 109(3):401-8. PMID: 11828000.
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    101. Porcu P, Emanueli C, Kapatsoris M, Chao J, Chao L, Madeddu P. Reversal of angiogenic growth factor upregulation by revascularization of lower limb ischemia. Circulation. 2002 Jan 01; 105(1):67-72. PMID: 11772878.
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    102. Chao J, Wang C, Chao L. Adenovirus-mediated gene transfer for cardiovascular and renal diseases. Methods Enzymol. 2002; 346:247-63. PMID: 11883071.
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    103. Donaldson SH, Hirsh A, Li DC, Holloway G, Chao J, Boucher RC, Gabriel SE. Regulation of the epithelial sodium channel by serine proteases in human airways. J Biol Chem. 2002 Mar 08; 277(10):8338-45. PMID: 11756432.
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    104. Wolf WC, Evans DM, Chao L, Chao J. A synthetic tissue kallikrein inhibitor suppresses cancer cell invasiveness. Am J Pathol. 2001 Nov; 159(5):1797-805. PMID: 11696440.
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    105. Chao J, Kato K, Zhang JJ, Dobrzynski E, Wang C, Agata J, Chao L. Human adrenomedullin gene delivery protects against cardiovascular remodeling and renal injury. Peptides. 2001 Nov; 22(11):1731-7. PMID: 11754958.
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    106. Wang C, Dobrzynski E, Chao J, Chao L. Adrenomedullin gene delivery attenuates renal damage and cardiac hypertrophy in Goldblatt hypertensive rats. Am J Physiol Renal Physiol. 2001 Jun; 280(6):F964-71. PMID: 11352835.
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    107. Chen VC, Chao L, Pimenta DC, Bledsoe G, Juliano L, Chao J. Identification of a major heparin-binding site in kallistatin. J Biol Chem. 2001 Jan 12; 276(2):1276-84. PMID: 11016932.
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    108. Chao J, Miao RQ, Chen V, Chen LM, Chao L. Novel roles of kallistatin, a specific tissue kallikrein inhibitor, in vascular remodeling. Biol Chem. 2001 Jan; 382(1):15-21. PMID: 11258665.
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    109. Chen VC, Chao L, Chao J. A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein. J Biol Chem. 2000 Dec 22; 275(51):40371-7. PMID: 10991942.
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    110. Chen VC, Chao L, Chao J. Roles of the P1, P2, and P3 residues in determining inhibitory specificity of kallistatin toward human tissue kallikrein. J Biol Chem. 2000 Dec 08; 275(49):38457-66. PMID: 10993887.
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    111. Dobrzynski E, Wang C, Chao J, Chao L. Adrenomedullin gene delivery attenuates hypertension, cardiac remodeling, and renal injury in deoxycorticosterone acetate-salt hypertensive rats. Hypertension. 2000 Dec; 36(6):995-1001. PMID: 11116114.
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    112. Zhang JJ, Yoshida H, Chao L, Chao J. Human adrenomedullin gene delivery protects against cardiac hypertrophy, fibrosis, and renal damage in hypertensive dahl salt-sensitive rats. Hum Gene Ther. 2000 Sep 01; 11(13):1817-27. PMID: 10986555.
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    113. Agata J, Miao RQ, Yayama K, Chao L, Chao J. Bradykinin B(1) receptor mediates inhibition of neointima formation in rat artery after balloon angioplasty. Hypertension. 2000 Sep; 36(3):364-70. PMID: 10988266.
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    114. Wolf WC, Yoshida H, Agata J, Chao L, Chao J. Human tissue kallikrein gene delivery attenuates hypertension, renal injury, and cardiac remodeling in chronic renal failure. Kidney Int. 2000 Aug; 58(2):730-9. PMID: 10916096.
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    115. Chen VC, Chao L, Chao J. Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis. Biochim Biophys Acta. 2000 Jun 15; 1479(1-2):237-46. PMID: 10862973.
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    116. Miao RQ, Murakami H, Song Q, Chao L, Chao J. Kallistatin stimulates vascular smooth muscle cell proliferation and migration in vitro and neointima formation in balloon-injured rat artery. Circ Res. 2000 Mar 03; 86(4):418-24. PMID: 10700446.
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    117. Wang D, Yoshida H, Song Q, Chao L, Chao J. Enhanced renal function in bradykinin B(2) receptor transgenic mice. Am J Physiol Renal Physiol. 2000 Mar; 278(3):F484-91. PMID: 10710553.
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    118. Yoshida H, Zhang JJ, Chao L, Chao J. Kallikrein gene delivery attenuates myocardial infarction and apoptosis after myocardial ischemia and reperfusion. Hypertension. 2000 Jan; 35(1 Pt 1):25-31. PMID: 10642270.
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    119. Dobrzynski E, Yoshida H, Chao J, Chao L. Adenovirus-mediated kallikrein gene delivery attenuates hypertension and protects against renal injury in deoxycorticosterone-salt rats. Immunopharmacology. 1999 Oct 15; 44(1-2):57-65. PMID: 10604525.
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    120. Murakami H, Miao RQ, Chao L, Chao J. Adenovirus-mediated kallikrein gene transfer inhibits neointima formation via increased production of nitric oxide in rat artery. Immunopharmacology. 1999 Oct 15; 44(1-2):137-43. PMID: 10604537.
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    121. Hatcher HC, Wright NM, Chao J, Chao L, Ma JX. Kallikrein-binding protein is induced by growth hormone in the dwarf rat. FASEB J. 1999 Oct; 13(13):1839-44. PMID: 10506588.
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    122. Li Z, Tyor WR, Xu J, Chao J, Hogan EL. Immunohistochemical localization of kininogen in rat spinal cord and brain. Exp Neurol. 1999 Oct; 159(2):528-37. PMID: 10506524.
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    123. Zhang JJ, Wang C, Lin KF, Chao L, Chao J. Human tissue kallikrein attenuates hypertension and secretes into circulation and urine after intramuscular gene delivery in hypertensive rats. Clin Exp Hypertens. 1999 Oct; 21(7):1145-60. PMID: 10513833.
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    124. Zhang JJ, Chao L, Chao J. Adenovirus-mediated kallikrein gene delivery reduces aortic thickening and stroke-induced death rate in Dahl salt-sensitive rats. Stroke. 1999 Sep; 30(9):1925-31; discussion 1931-2. PMID: 10471446.
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    125. Murakami H, Yayama K, Miao RQ, Wang C, Chao L, Chao J. Kallikrein gene delivery inhibits vascular smooth muscle cell growth and neointima formation in the rat artery after balloon angioplasty. Hypertension. 1999 Aug; 34(2):164-70. PMID: 10454435.
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    126. Murakami H, Yayama K, Chao J, Chao L. Atrial natriuretic peptide gene delivery attenuates gentamycin-induced nephrotoxicity in rats. Nephrol Dial Transplant. 1999 Jun; 14(6):1376-84. PMID: 10382996.
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    127. Jin L, Chao L, Chao J. Potassium supplement upregulates the expression of renal kallikrein and bradykinin B2 receptor in SHR. Am J Physiol. 1999 03; 276(3):F476-84. PMID: 10070172.
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    128. Wolf WC, Harley RA, Sluce D, Chao L, Chao J. Localization and expression of tissue kallikrein and kallistatin in human blood vessels. J Histochem Cytochem. 1999 Feb; 47(2):221-8. PMID: 9889257.
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    129. Chao J, Wang C, Chao L. Gene therapy for hypertension: a review of potential targets. BioDrugs. 1999 Jan; 11(1):43-53. PMID: 18031114.
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    130. Lin KF, Chao J, Chao L. Atrial natriuretic peptide gene delivery reduces stroke-induced mortality rate in Dahl salt-sensitive rats. Hypertension. 1999 Jan; 33(1 Pt 2):219-24. PMID: 9931108.
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    131. Ni A, Chai KX, Chao L, Chao J. Molecular cloning and expression of rat bradykinin B1 receptor. Biochim Biophys Acta. 1998 Nov 08; 1442(2-3):177-85. PMID: 9804950.
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    132. Wolf WC, Harley RA, Sluce D, Chao L, Chao J. Cellular localization of kallistatin and tissue kallikrein in human pancreas and salivary glands. Histochem Cell Biol. 1998 Nov; 110(5):477-84. PMID: 9826127.
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    133. Chao J, Zhang JJ, Lin KF, Chao L. Adenovirus-mediated kallikrein gene delivery reverses salt-induced renal injury in Dahl salt-sensitive rats. Kidney Int. 1998 Oct; 54(4):1250-60. PMID: 9767541.
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    134. Lin KF, Chao J, Chao L. Atrial natriuretic peptide gene delivery attenuates hypertension, cardiac hypertrophy, and renal injury in salt-sensitive rats. Hum Gene Ther. 1998 Jul 01; 9(10):1429-38. PMID: 9681414.
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    135. Murakami H, Yayama K, Chao L, Chao J. Human kallikrein gene delivery protects against gentamycin-induced nephrotoxicity in rats. Kidney Int. 1998 May; 53(5):1305-13. PMID: 9573546.
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    136. Yayama K, Wang C, Chao L, Chao J. Kallikrein gene delivery attenuates hypertension and cardiac hypertrophy and enhances renal function in Goldblatt hypertensive rats. Hypertension. 1998 May; 31(5):1104-10. PMID: 9576121.
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    137. Wang C, Chao C, Madeddu P, Chao L, Chao J. Central delivery of human tissue kallikrein gene reduces blood pressure in hypertensive rats. Biochem Biophys Res Commun. 1998 Mar 17; 244(2):449-54. PMID: 9514899.
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    138. Ni A, Chao L, Chao J. Transcription factor nuclear factor kappaB regulates the inducible expression of the human B1 receptor gene in inflammation. J Biol Chem. 1998 Jan 30; 273(5):2784-91. PMID: 9446586.
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    139. Chao J, Zhang JJ, Lin KF, Chao L. Human kallikrein gene delivery attenuates hypertension, cardiac hypertrophy, and renal injury in Dahl salt-sensitive rats. Hum Gene Ther. 1998 Jan 01; 9(1):21-31. PMID: 9458239.
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    140. Chao J, Jin L, Lin KF, Chao L. Adrenomedullin gene delivery reduces blood pressure in spontaneously hypertensive rats. Hypertens Res. 1997 Dec; 20(4):269-77. PMID: 9453262.
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    141. Wang C, Ford P, Chao C, Chao L, Chao J. Effect of cyclosporin A on the expression of tissue kallikrein, kininogen, and bradykinin receptor in rat. Am J Physiol. 1997 11; 273(5):F783-9. PMID: 9374842.
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    142. Chao J, Chao L. Kallistatin in blood pressure regulation transgenic and somatic gene delivery studies. Trends Cardiovasc Med. 1997 Nov; 7(8):307-11. PMID: 21235901.
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    143. Jin L, Zhang JJ, Chao L, Chao J. Gene therapy in hypertension: adenovirus-mediated kallikrein gene delivery in hypertensive rats. Hum Gene Ther. 1997 Oct 10; 8(15):1753-61. PMID: 9358025.
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    144. Chai KX, Chen VC, Ni A, Lindpaintner K, Rubattu S, Chao L, Chao J. Molecular cloning and expression of rat kallistatin gene. Biochim Biophys Acta. 1997 Sep 12; 1353(3):277-86. PMID: 9349723.
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    145. Lin KF, Chao L, Chao J. Prolonged reduction of high blood pressure with human nitric oxide synthase gene delivery. Hypertension. 1997 Sep; 30(3 Pt 1):307-13. PMID: 9314409.
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    146. Chao J, Chao L. New experimental evidence for a role of tissue kallikrein in hypertension. Nephrol Dial Transplant. 1997 Aug; 12(8):1569-74. PMID: 9269631.
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    147. Chao J, Stallone JN, Liang YM, Chen LM, Wang DZ, Chao L. Kallistatin is a potent new vasodilator. J Clin Invest. 1997 Jul 01; 100(1):11-7. PMID: 9202051.
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    148. Xiong W, Wang J, Chao L, Chao J. Tissue-specific expression and promoter analyses of the human tissue kallikrein gene in transgenic mice. Biochem J. 1997 Jul 01; 325 ( Pt 1):111-6. PMID: 9224635.
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    149. Chao J, Yang Z, Jin L, Lin KF, Chao L. Kallikrein gene therapy in newborn and adult hypertensive rats. Can J Physiol Pharmacol. 1997 Jun; 75(6):750-6. PMID: 9276159.
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    150. Chao J, Chao L. Kallikrein gene therapy: a new strategy for hypertensive diseases. Immunopharmacology. 1997 Jun; 36(2-3):229-36. PMID: 9228551.
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    151. Chao J, Chao L. Experimental kallikrein gene therapy in hypertension, cardiovascular and renal diseases. Pharmacol Res. 1997 Jun; 35(6):517-22. PMID: 9356201.
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    152. Song Q, Chao J, Chao L. DNA polymorphisms in the 5'-flanking region of the human tissue kallikrein gene. Hum Genet. 1997 Jun; 99(6):727-34. PMID: 9187664.
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    153. Wang C, Chao C, Chao L, Chao J. Expression of human tissue kallikrein in rat salivary glands and its secretion into circulation following adenovirus-mediated gene transfer. Immunopharmacology. 1997 Jun; 36(2-3):221-7. PMID: 9228550.
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    154. Hatcher HC, Ma JX, Chao J, Chao L, Ottlecz A. Kallikrein-binding protein levels are reduced in the retinas of streptozotocin-induced diabetic rats. Invest Ophthalmol Vis Sci. 1997 Mar; 38(3):658-64. PMID: 9071220.
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    155. Xiong W, Chao J, Chao L. Expression and localization of human kallistatin in rat submandibular gland after intracapsular gene injection. Biochem Biophys Res Commun. 1997 Feb 13; 231(2):494-8. PMID: 9070307.
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    156. Chen LM, Chao L, Chao J. Adenovirus-mediated delivery of human kallistatin gene reduces blood pressure of spontaneously hypertensive rats. Hum Gene Ther. 1997 Feb 10; 8(3):341-7. PMID: 9048201.
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    157. Chen LM, Chao L, Chao J. Beneficial effects of kallikrein-binding protein in transgenic mice during endotoxic shock. Life Sci. 1997; 60(17):1431-5. PMID: 9126863.
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    158. Wang DZ, Chao L, Chao J. Hypotension in transgenic mice overexpressing human bradykinin B2 receptor. Hypertension. 1997 Jan; 29(1 Pt 2):488-93. PMID: 9039147.
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    159. Ma JX, King LP, Yang Z, Crouch RK, Chao L, Chao J. Kallistatin in human ocular tissues: reduced levels in vitreous fluids from patients with diabetic retinopathy. Curr Eye Res. 1996 Nov; 15(11):1117-23. PMID: 8950506.
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    160. Song Q, Chao J, Chao L. High level of circulating human tissue kallikrein induces hypotension in a transgenic mouse model. Clin Exp Hypertens. 1996 Nov; 18(8):975-93. PMID: 8922341.
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    161. Chen LM, Ma Jx, Liang YM, Chao L, Chao J. Tissue kallikrein-binding protein reduces blood pressure in transgenic mice. J Biol Chem. 1996 Nov 01; 271(44):27590-4. PMID: 8910346.
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    162. Wang C, Chao C, Chen LM, Chao L, Chao J. High-salt diet upregulates kininogen and downregulates tissue kallikrein expression in Dahl-SS and SHR rats. Am J Physiol. 1996 Oct; 271(4 Pt 2):F824-30. PMID: 8898012.
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    163. Wang DZ, Song Q, Chen LM, Chao L, Chao J. Expression and cellular localization of tissue kallikrein-kinin system in human adrenal gland. Am J Physiol. 1996 Sep; 271(3 Pt 2):F709-16. PMID: 8853434.
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    164. Ma JX, Chao J, Chao L. Identification and characterization of two promoters of rat kallikrein-binding protein gene. Biochim Biophys Acta. 1996 Jul 17; 1307(3):285-93. PMID: 8688463.
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    165. Ma JX, Song Q, Hatcher HC, Crouch RK, Chao L, Chao J. Expression and cellular localization of the kallikrein-kinin system in human ocular tissues. Exp Eye Res. 1996 Jul; 63(1):19-26. PMID: 8983960.
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    166. Chao C, Madeddu P, Wang C, Liang Y, Chao L, Chao J. Differential regulation of kallikrein, kininogen, and kallikrein-binding protein in arterial hypertensive rats. Am J Physiol. 1996 Jul; 271(1 Pt 2):F78-86. PMID: 8760246.
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    167. Chao J, Schmaier A, Chen LM, Yang Z, Chao L. Kallistatin, a novel human tissue kallikrein inhibitor: levels in body fluids, blood cells, and tissues in health and disease. J Lab Clin Med. 1996 Jun; 127(6):612-20. PMID: 8648266.
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    168. Song Q, Wang DZ, Harley RA, Chao L, Chao J. Cellular localization of low-molecular-weight kininogen and bradykinin B2 receptor mRNAs in human kidney. Am J Physiol. 1996 Jun; 270(6 Pt 2):F919-26. PMID: 8764310.
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    169. Wang DZ, Chao L, Chao J. Cellular localization of bradykinin B1 receptor mRNA in the human kidney. Immunopharmacology. 1996 Jun; 33(1-3):151-6. PMID: 8856137.
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    170. Chao J, Jin L, Chen LM, Chen VC, Chao L. Systemic and portal vein delivery of human kallikrein gene reduces blood pressure in hypertensive rats. Hum Gene Ther. 1996 May 20; 7(8):901-11. PMID: 8727504.
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    171. Chao J, Chai KX, Chao L. Tissue kallikrein inhibitors in mammals. Immunopharmacology. 1996 May; 32(1-3):67-72. PMID: 8796269.
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    172. Song Q, Chao J, Chao L. High level expression of human tissue kallikrein in the circulation induces hypotension in transgenic mice. Immunopharmacology. 1996 May; 32(1-3):105-7. PMID: 8796281.
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    173. Yu JX, Chao L, Ward DC, Chao J. Structure and chromosomal localization of the human prostasin (PRSS8) gene. Genomics. 1996 Mar 15; 32(3):334-40. PMID: 8838796.
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    174. Chao J, Chao L. Functional analysis of human tissue kallikrein in transgenic mouse models. Hypertension. 1996 Mar; 27(3 Pt 2):491-4. PMID: 8613191.
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    175. Chai KX, Ni A, Wang D, Ward DC, Chao J, Chao L. Genomic DNA sequence, expression, and chromosomal localization of the human B1 bradykinin receptor gene BDKRB1. Genomics. 1996 Jan 01; 31(1):51-7. PMID: 8808279.
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    176. Wang C, Chen YP, Chao L, Chao J. Regulatory elements in the promoter region of the renal kallikrein gene in normotensive vs hypertensive rats. Biochem Biophys Res Commun. 1995 Dec 05; 217(1):113-22. PMID: 8526898.
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    177. Chao J, Chao L. Biochemistry, regulation and potential function of kallistatin. Biol Chem Hoppe Seyler. 1995 Dec; 376(12):705-13. PMID: 9072045.
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    178. Lin KF, Chao J, Chao L. Human atrial natriuretic peptide gene delivery reduces blood pressure in hypertensive rats. Hypertension. 1995 Dec; 26(6 Pt 1):847-53. PMID: 7490138.
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    179. Chen LM, Song Q, Chao L, Chao J. Cellular localization of tissue kallikrein and kallistatin mRNAs in human kidney. Kidney Int. 1995 Sep; 48(3):690-7. PMID: 7474653.
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    180. Yu JX, Chao L, Chao J. Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA. J Biol Chem. 1995 Jun 02; 270(22):13483-9. PMID: 7768952.
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    181. Chen LM, Richards GP, Chao L, Chao J. Molecular cloning, purification and in situ localization of human colon kallikrein. Biochem J. 1995 Apr 15; 307 ( Pt 2):481-6. PMID: 7733886.
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    182. Wang C, Chao L, Chao J. Direct gene delivery of human tissue kallikrein reduces blood pressure in spontaneously hypertensive rats. J Clin Invest. 1995 Apr; 95(4):1710-6. PMID: 7535795.
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    183. Xiong W, Chao J, Chao L. Muscle delivery of human kallikrein gene reduces blood pressure in hypertensive rats. Hypertension. 1995 Apr; 25(4 Pt 2):715-9. PMID: 7721421.
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    184. Ma JX, Yang Z, Chao J, Chao L. Intramuscular delivery of rat kallikrein-binding protein gene reverses hypotension in transgenic mice expressing human tissue kallikrein. J Biol Chem. 1995 Jan 06; 270(1):451-5. PMID: 7814410.
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    185. Ma JX, Wang DZ, Chao L, Chao J. Cloning, sequence analysis and expression of the gene encoding the mouse bradykinin B2 receptor. Gene. 1994 Nov 18; 149(2):283-8. PMID: 7959003.
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    186. Simson JA, Wang J, Chao J, Chao L. Histopathology of lymphatic tissues in transgenic mice expressing human tissue kallikrein gene. Lab Invest. 1994 Nov; 71(5):680-7. PMID: 7967521.
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    187. Ma JX, Wang DZ, Ward DC, Chen L, Dessai T, Chao J, Chao L. Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor. Genomics. 1994 Sep 15; 23(2):362-9. PMID: 7835885.
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    188. Chai KX, Ward DC, Chao J, Chao L. Molecular cloning, sequence analysis, and chromosomal localization of the human protease inhibitor 4 (kallistatin) gene (PI4). Genomics. 1994 Sep 15; 23(2):370-8. PMID: 7835886.
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    189. Wang DZ, Ma JX, Chao L, Chao J. Molecular cloning and sequence analysis of rat bradykinin B2 receptor gene. Biochim Biophys Acta. 1994 Sep 13; 1219(1):171-4. PMID: 8086459.
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    190. Chen LM, Murray SR, Chai KX, Chao L, Chao J. Molecular cloning and characterization of a novel kallikrein transcript in colon and its distribution in human tissues. Braz J Med Biol Res. 1994 Aug; 27(8):1829-38. PMID: 7749372.
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    191. Yu JX, Chao L, Chao J. Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland. J Biol Chem. 1994 Jul 22; 269(29):18843-8. PMID: 8034638.
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    192. Simson JA, Chao J. Subcellular distribution of tissue kallikrein and Na,K-ATPase alpha-subunit in rat parotid striated duct cells. Cell Tissue Res. 1994 Mar; 275(3):407-17. PMID: 8137393.
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    193. Wang J, Xiong W, Yang Z, Davis T, Dewey MJ, Chao J, Chao L. Human tissue kallikrein induces hypotension in transgenic mice. Hypertension. 1994 Feb; 23(2):236-43. PMID: 7508423.
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    194. Chai KX, Chen LM, Chao J, Chao L. Kallistatin: a novel human serine proteinase inhibitor. Molecular cloning, tissue distribution, and expression in Escherichia coli. J Biol Chem. 1993 Nov 15; 268(32):24498-505. PMID: 8227002.
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    195. Ma JX, Chao L, Zhou G, Chao J. Expression and characterization of rat kallikrein-binding protein in Escherichia coli. Biochem J. 1993 Jun 15; 292 ( Pt 3):825-32. PMID: 8318011.
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    196. Chao J, Simson JA, Chung P, Chen LM, Chao L. Regulation of kininogen gene expression and localization in the lung after monocrotaline-induced pulmonary hypertension in rats. . 1993 Jun; 203(2):243-50. PMID: 8502664.
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    197. Chao J, Chai KX, Chao L. Screening of complementary DNA library using radiolabeled antigen. Methods Enzymol. 1993; 217:325-35. PMID: 8474338.
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    198. Zhou GX, Chao L, Chao J. Kallistatin: a novel human tissue kallikrein inhibitor. Purification, characterization, and reactive center sequence. J Biol Chem. 1992 Dec 25; 267(36):25873-80. PMID: 1334488.
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    199. Ma JX, Chao J, Chao L. Molecular cloning and characterization of rKlk10, a cDNA encoding T-kininogenase from rat submandibular gland and kidney. Biochemistry. 1992 Nov 10; 31(44):10922-8. PMID: 1420203.
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    200. Wang J, Chao J, Chao L. Specificity determinants of rat tissue kallikrein probed by site-directed mutagenesis. Protein Eng. 1992 Sep; 5(6):569-75. PMID: 1438168.
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    201. Wang C, Tang CQ, Zhou GX, Chao L, Chao J. Biochemical characterization and substrate specificity of rat prostate kallikrein (S3): comparison with tissue kallikrein, tonin and T-kininogenase. Biochim Biophys Acta. 1992 Jun 24; 1121(3):309-16. PMID: 1320938.
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    202. Chen LM, Chung P, Chao S, Chao L, Chao J. Differential regulation of kininogen gene expression by estrogen and progesterone in vivo. Biochim Biophys Acta. 1992 Jun 15; 1131(2):145-51. PMID: 1610894.
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    203. Xiong W, Tang CQ, Zhou GX, Chao L, Chao J. In vivo catabolism of human kallikrein-binding protein and its complex with tissue kallikrein. J Lab Clin Med. 1992 May; 119(5):514-21. PMID: 1583408.
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    204. Jaffa AA, Chai KX, Chao J, Chao L, Mayfield RK. Effects of diabetes and insulin on expression of kallikrein and renin genes in the kidney. Kidney Int. 1992 Apr; 41(4):789-95. PMID: 1513101.
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    205. Chao J, Chen LM, Chai KX, Chao L. Expression of kallikrein-binding protein and alpha 1-antitrypsin genes in response to sex hormones, growth, inflammation and hypertension. Agents Actions Suppl. 1992; 38 ( Pt 1):174-81. PMID: 1466268.
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    206. Murray SR, Chao J, Chao L. Evolution of the kallikrein gene family. Agents Actions Suppl. 1992; 38 ( Pt 1):26-33. PMID: 1466278.
      Citations:    
    207. Simson JA, Chao J, Chao L. Localization of kallikrein gene family proteases in rat tissues. Agents Actions Suppl. 1992; 38 ( Pt 1):595-602. PMID: 1334634.
      Citations:    
    208. Wang J, Chao J, Juliano L, Chao L. Comparative studies on P2 specificity of wild-type rat tissue kallikrein, Y99H:W215G mutant and tonin. Agents Actions Suppl. 1992; 38 ( Pt 1):59-65. PMID: 1334633.
      Citations:    
    209. Chai KX, Chao J, Chao L. Molecular cloning and sequence analysis of the mouse kallikrein-binding protein gene. Biochim Biophys Acta. 1991 Dec 02; 1129(1):127-30. PMID: 1756173.
      Citations:    
    210. Xu J, Hsu CY, Junker H, Chao S, Hogan EL, Chao J. Kininogen and kinin in experimental spinal cord injury. J Neurochem. 1991 Sep; 57(3):975-80. PMID: 1861161.
      Citations:    
    211. Chai KX, Ma JX, Murray SR, Chao J, Chao L. Molecular cloning and analysis of the rat kallikrein-binding protein gene. J Biol Chem. 1991 Aug 25; 266(24):16029-36. PMID: 1874745.
      Citations:    
    212. Wang J, Chao J, Chao L. Purification and characterization of recombinant tissue kallikrein from Escherichia coli and yeast. Biochem J. 1991 May 15; 276 ( Pt 1):63-71. PMID: 2039483.
      Citations:    
    213. Chao J, Chai KX, Chen LM, Xiong W, Chao S, Woodley-Miller C, Wang LX, Lu HS, Chao L. Tissue kallikrein-binding protein is a serpin. I. Purification, characterization, and distribution in normotensive and spontaneously hypertensive rats. J Biol Chem. 1990 Sep 25; 265(27):16394-401. PMID: 2398056.
      Citations:    
    214. Xiong W, Chen LM, Woodley-Miller C, Simson JA, Chao J. Identification, purification, and localization of tissue kallikrein in rat heart. Biochem J. 1990 May 01; 267(3):639-46. PMID: 2140256.
      Citations:    
    215. Chen LM, Chao L, Mayfield RK, Chao J. Differential interactions of human kallikrein-binding protein and alpha 1-antitrypsin with human tissue kallikrein. Biochem J. 1990 Apr 01; 267(1):79-84. PMID: 2327990.
      Citations:    
    216. Xiong W, Chen LM, Chao J. Purification and characterization of a kallikrein-like T-kininogenase. J Biol Chem. 1990 Feb 15; 265(5):2822-7. PMID: 2303430.
      Citations:    
    217. Chao S, Chai KX, Chao L, Chao J. Molecular cloning and primary structure of rat alpha 1-antitrypsin. Biochemistry. 1990 Jan 16; 29(2):323-9. PMID: 2302382.
      Citations:    
    218. Murray SR, Chao J, Lin FK, Chao L. Kallikrein multigene families and the regulation of their expression. J Cardiovasc Pharmacol. 1990; 15 Suppl 6:S7-16. PMID: 1697365.
      Citations:    
    219. Simson JA, Currie MG, Chao L, Chao J. Co-localization of a kallikrein-like serine protease (arginine esterase A) and atrial natriuretic peptide in rat atrium. J Histochem Cytochem. 1989 Dec; 37(12):1913-7. PMID: 2531183.
      Citations:    
    220. Woodley-Miller C, Chao J, Chao L. Restriction fragment length polymorphisms mapped in spontaneously hypertensive rats using kallikrein probes. J Hypertens. 1989 Nov; 7(11):865-71. PMID: 2575114.
      Citations:    
    221. Shai SY, Woodley-Miller C, Chao J, Chao L. Characterization of genes encoding rat tonin and a kallikrein-like serine protease. Biochemistry. 1989 Jun 27; 28(13):5334-43. PMID: 2550051.
      Citations:    
    222. Chao S, Chao L, Chao J. Sex dimorphism and inflammatory regulation of T-kininogen and T-kininogenase. Biochim Biophys Acta. 1989 Jun 27; 991(3):477-83. PMID: 2730923.
      Citations:    
    223. Xiong W, Chao L, Chao J. Renal kallikrein mRNA localization by in situ hybridization. Kidney Int. 1989 Jun; 35(6):1324-9. PMID: 2770112.
      Citations:    
    224. Chao J, Chao S, Xiong W, Chen LM, Swain C, Chao L. Sex dimorphism and estrogen regulation of kininogens in rat serum, adrenal gland and kidney. Adv Exp Med Biol. 1989; 247B:297-303. PMID: 2610078.
      Citations:    
    225. Hsu CY, Liu TH, Xu J, Hogan EL, Chao J, Sun G, Tai HH, Beckman JS, Freeman BA. Arachidonic acid and its metabolites in cerebral ischemia. Ann N Y Acad Sci. 1989; 559:282-95. PMID: 2774402.
      Citations:    
    226. Wang MY, Day J, Chao L, Chao J. Human kallistatin, a new tissue kallikrein-binding protein: purification and characterization. Adv Exp Med Biol. 1989; 247B:1-8. PMID: 2558505.
      Citations:    
    227. Chao S, Chao L, Chao J. Enhanced specificity in immunoscreening of expression cDNA clones using radiolabeled antigen overlay. Biotechniques. 1989 Jan; 7(1):68-72. PMID: 2629834.
      Citations:    
    228. Chao L, Chen YP, Woodley-Miller C, Li LY, von Harten K, Chao J. Structural analysis of a rat renal kallikrein gene. Adv Exp Med Biol. 1989; 247A:73-80. PMID: 2481394.
      Citations:    
    229. Hughes GS, Margolius HS, Peters R, Oexmann MJ, Chao J, Lindenmayer G. Gender differences of human tissue kallikrein and an erythrocyte kallikrein-like enzyme in essential hypertension. J Lab Clin Med. 1988 Nov; 112(5):612-8. PMID: 3183493.
      Citations:    
    230. Simson JA, Condon JL, Chao L, Chao J. Comparison of the distribution of tissue kallikrein and esterase A, a kallikrein-like enzyme, in rat kidney using specific monoclonal antibodies. J Histochem Cytochem. 1988 Oct; 36(10):1251-4. PMID: 3418106.
      Citations:    
    231. Chen YP, Chao J, Chao L. Molecular cloning and characterization of two rat renal kallikrein genes. Biochemistry. 1988 Sep 20; 27(19):7189-96. PMID: 2849988.
      Citations:    
    232. Chao J, Chao L. A major difference of kallikrein-binding protein in spontaneously hypertensive versus normotensive rats. J Hypertens. 1988 Jul; 6(7):551-7. PMID: 3171170.
      Citations:    
    233. Simson JA, Condon J, Fenters R, Chao L, Chao J. Immunocytochemical localization of a kallikrein-like serine protease (esterase A) in rat salivary glands. Anat Rec. 1988 May; 221(1):475-81. PMID: 3291641.
      Citations:    
    234. Chao J, Swain C, Chao S, Xiong W, Chao L. Tissue distribution and kininogen gene expression after acute-phase inflammation. Biochim Biophys Acta. 1988 Mar 17; 964(3):329-39. PMID: 3126819.
      Citations:    
    235. Chao J, Mayfield RK, Chao L. Circulating autoantibodies to mammalian tissue kallikreins. . 1988 Mar; 187(3):320-6. PMID: 3347609.
      Citations:    
    236. Chao J, Chao L. Identification of latent tissue kallikrein, prolactin and growth hormone secretion in GH3 pituitary cells using modified radioimmunoassays. Mol Cell Endocrinol. 1988 Jan; 55(1):21-31. PMID: 3360206.
      Citations:    
    237. Chao J, Chao L. Identification and expression of kallikrein gene family in rat submandibular and prostate glands using monoclonal antibodies as specific probes. Biochim Biophys Acta. 1987 Dec 08; 910(3):233-9. PMID: 2823901.
      Citations:    
    238. Simson JA, Rowell C, Barrett JM, King J, Chao J. Rat urinary kallikrein localization in kidney: effects of fixation. Histochem J. 1987 Dec; 19(12):633-42. PMID: 3443557.
      Citations:    
    239. Jaffa AA, Miller DH, Bailey GS, Chao J, Margolius HS, Mayfield RK. Abnormal regulation of renal kallikrein in experimental diabetes. Effects of insulin on prokallikrein synthesis and activation. J Clin Invest. 1987 Dec; 80(6):1651-9. PMID: 3316279.
      Citations:    
    240. Woodley-Miller C, Chao J, Chao L. Identification of tonin in brain and exocrine tissues and in the cell-free translation products encoded by the mRNA of these tissues. Biochem J. 1987 Dec 01; 248(2):477-81. PMID: 2829829.
      Citations:    
    241. Shimojo N, Chao J, Chao L, Margolius HS, Mayfield RK. Identification and characterization of a tissue kallikrein in rat skeletal muscles. Biochem J. 1987 May 01; 243(3):773-8. PMID: 3311022.
      Citations:    
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