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Arthur Charles Riegel

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InstitutionMedical University of South Carolina
DepartmentNeuroscience
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    Research Interests:
    Our laboratory is interested in dopamine for its broad role in motor and motivational systems including cognition, attention and learning. We use experimental approaches in animals to investigate the synaptic brain circuitry tuned to support these behaviors. We also investigate the related neuroadaptive changes (synaptic plasticity), which may underlie prevalent diseases such as Parkinson's disease, psychosis, schizophrenia, and Tourette's syndrome.

    Addiction is a disease of abnormal habits or learned behaviors, Researching addiction provides unique insights into the mechanisms underlying learning and how they influence addictive behavior. Virtually all drugs of abuse, including cocaine, amphetamine, heroin and other opiates, alcohol, nicotine and volatile solvents activate dopaminergic systems in the brain. Current research in our laboratory utilizes in vitro electrophysiology (whole cell patch clamp), calcium neuroimaging and uncaging (flash photolysis) in combination with behavioral self-administration to better understand the role of dopamine in normal and abnormal brain function.
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    Neuroscience of addiction & disease, synaptic physiology & receptor pharmacology, cell biology & neuronal signaling

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Buchta WC, Moutal A, Hines B, Garcia-Keller C, Smith ACW, Kalivas P, Khanna R, Riegel AC. Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking. Mol Neurobiol. 2020 Jan; 57(1):346-357. PMID: 31359322.
      View in: PubMed
    2. Mahler SV, Brodnik ZD, Cox BM, Buchta WC, Bentzley BS, Quintanilla J, Cope ZA, Lin EC, Riedy MD, Scofield MD, Messinger J, Ruiz CM, Riegel AC, EspaƱa RA, Aston-Jones G. Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse. J Neurosci. 2019 01 16; 39(3):503-518. PMID: 30446532.
      View in: PubMed
    3. Harlan BA, Becker HC, Woodward JJ, Riegel AC. Opposing actions of CRF-R1 and CB1 receptors on VTA-GABAergic plasticity following chronic exposure to ethanol. Neuropsychopharmacology. 2018 09; 43(10):2064-2074. PMID: 29946104.
      View in: PubMed
    4. Parrilla-Carrero J, Buchta WC, Goswamee P, Culver O, McKendrick G, Harlan B, Moutal A, Penrod R, Lauer A, Ramakrishnan V, Khanna R, Kalivas P, Riegel AC. Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking. J Neurosci. 2018 04 25; 38(17):4212-4229. PMID: 29636392.
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    5. Buchta WC, Mahler SV, Harlan B, Aston-Jones GS, Riegel AC. Dopamine terminals from the ventral tegmental area gate intrinsic inhibition in the prefrontal cortex. Physiol Rep. 2017 Mar; 5(6). PMID: 28325790.
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    6. Buchta WC, Riegel AC. Chronic cocaine disrupts mesocortical learning mechanisms. Brain Res. 2015 Dec 02; 1628(Pt A):88-103. PMID: 25704202.
      View in: PubMed
    7. Williams CL, Buchta WC, Riegel AC. CRF-R2 and the heterosynaptic regulation of VTA glutamate during reinstatement of cocaine seeking. J Neurosci. 2014 Jul 30; 34(31):10402-14. PMID: 25080599.
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    8. Moussawi K, Riegel A, Nair S, Kalivas PW. Extracellular glutamate: functional compartments operate in different concentration ranges. Front Syst Neurosci. 2011; 5:94. PMID: 22275885.
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    9. Riegel AC, Kalivas PW. Neuroscience: Lack of inhibition leads to abuse. Nature. 2010 Feb 11; 463(7282):743-4. PMID: 20148025.
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    10. Riegel AC, Williams JT. CRF facilitates calcium release from intracellular stores in midbrain dopamine neurons. Neuron. 2008 Feb 28; 57(4):559-70. PMID: 18304485.
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    11. Riegel AC, Zapata A, Shippenberg TS, French ED. The abused inhalant toluene increases dopamine release in the nucleus accumbens by directly stimulating ventral tegmental area neurons. Neuropsychopharmacology. 2007 Jul; 32(7):1558-69. PMID: 17213847.
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    12. Lupica CR, Riegel AC. Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction. Neuropharmacology. 2005 Jun; 48(8):1105-16. PMID: 15878779.
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    13. Riegel AC, Lupica CR. Independent presynaptic and postsynaptic mechanisms regulate endocannabinoid signaling at multiple synapses in the ventral tegmental area. J Neurosci. 2004 Dec 08; 24(49):11070-8. PMID: 15590923.
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    14. Riegel AC, Ali SF, Torinese S, French ED. Repeated exposure to the abused inhalant toluene alters levels of neurotransmitters and generates peroxynitrite in nigrostriatal and mesolimbic nuclei in rat. Ann N Y Acad Sci. 2004 Oct; 1025:543-51. PMID: 15542760.
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    15. Lupica CR, Riegel AC, Hoffman AF. Marijuana and cannabinoid regulation of brain reward circuits. Br J Pharmacol. 2004 Sep; 143(2):227-34. PMID: 15313883.
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    16. Hoffman AF, Riegel AC, Lupica CR. Functional localization of cannabinoid receptors and endogenous cannabinoid production in distinct neuron populations of the hippocampus. Eur J Neurosci. 2003 Aug; 18(3):524-34. PMID: 12911748.
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    17. Riegel AC, Ali SF, French ED. Toluene-induced locomotor activity is blocked by 6-hydroxydopamine lesions of the nucleus accumbens and the mGluR2/3 agonist LY379268. Neuropsychopharmacology. 2003 Aug; 28(8):1440-7. PMID: 12784113.
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    18. Riegel AC, French ED. Abused inhalants and central reward pathways: electrophysiological and behavioral studies in the rat. Ann N Y Acad Sci. 2002 Jun; 965:281-91. PMID: 12105104.
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    19. Riegel AC, French ED. An electrophysiological analysis of rat ventral tegmental dopamine neuronal activity during acute toluene exposure. Pharmacol Toxicol. 1999 Jul; 85(1):37-43. PMID: 10426162.
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    20. Riegel AC, French ED. The susceptibility of rat non-dopamine ventral tegmental neurones to inhibition during toluene exposure. Pharmacol Toxicol. 1999 Jul; 85(1):44-6. PMID: 10426163.
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    21. Riegel AC, French ED. Acute toluene induces biphasic changes in rat spontaneous locomotor activity which are blocked by remoxipride. Pharmacol Biochem Behav. 1999 Mar; 62(3):399-402. PMID: 10080229.
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