 Tissue Plasminogen Activator
"Tissue Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
| Descriptor ID |
D010959
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| MeSH Number(s) |
D08.811.277.656.300.760.875 D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970
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| Concept/Terms |
Tissue Plasminogen Activator- Tissue Plasminogen Activator
- Plasminogen Activator, Tissue
- Tissue Activator D-44
- Tissue Activator D 44
- Tisokinase
- Tissue-Type Plasminogen Activator
- Tissue Type Plasminogen Activator
- TTPA
- T-Plasminogen Activator
- T Plasminogen Activator
- Alteplase
- Plasminogen Activator, Tissue-Type
- Plasminogen Activator, Tissue Type
Activase- Activase
- Hoffmann-La Roche Brand of Alteplase
- Hoffmann La Roche Brand of Alteplase
- Genentech Brand of Alteplase
- Alteplase Genentech Brand
Actilyse- Actilyse
- Boehringer Ingelheim Brand of Alteplase
- Lysatec rt-PA
- Lysatec rt PA
- Lysatec rtPA
- Promeco Brand of Alteplase
- Alteplase Promeco Brand
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Below are MeSH descriptors whose meaning is more general than "Tissue Plasminogen Activator".
Below are MeSH descriptors whose meaning is more specific than "Tissue Plasminogen Activator".
This graph shows the total number of publications written about "Tissue Plasminogen Activator" by people in this website by year, and whether "Tissue Plasminogen Activator" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 1 | 0 | 1 | | 1992 | 1 | 0 | 1 | | 1994 | 0 | 3 | 3 | | 1995 | 0 | 1 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 2 | 1 | 3 | | 1998 | 2 | 0 | 2 | | 1999 | 3 | 1 | 4 | | 2000 | 3 | 0 | 3 | | 2001 | 3 | 2 | 5 | | 2002 | 4 | 2 | 6 | | 2003 | 3 | 2 | 5 | | 2004 | 7 | 7 | 14 | | 2005 | 5 | 2 | 7 | | 2006 | 3 | 3 | 6 | | 2007 | 1 | 5 | 6 | | 2008 | 3 | 1 | 4 | | 2009 | 4 | 0 | 4 | | 2010 | 4 | 3 | 7 | | 2011 | 2 | 3 | 5 | | 2012 | 3 | 4 | 7 | | 2013 | 9 | 5 | 14 | | 2014 | 13 | 3 | 16 | | 2015 | 8 | 5 | 13 | | 2016 | 6 | 3 | 9 | | 2017 | 7 | 2 | 9 | | 2018 | 10 | 2 | 12 | | 2019 | 5 | 4 | 9 | | 2020 | 5 | 3 | 8 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tissue Plasminogen Activator" by people in Profiles.
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Al Kasab S, Almallouhi E, Grant C, Hewitt D, Hewitt J, Baki M, Sabatino P, Jones D, Holmstedt CA. Telestroke Consultation in the Emergency Medical Services Unit: A Novel Approach to Improve Thrombolysis Times. J Stroke Cerebrovasc Dis. 2021 May; 30(5):105710.
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Moraney R, Poupore N, Shugart R, Tate M, Snell A, Brown K, Nathaniel TI. Thrombolytic therapy in ischemic stroke patients with pre-stroke depression in the telestroke vs non-telestroke. J Stroke Cerebrovasc Dis. 2020 Sep; 29(9):104890.
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Poupore N, Strat D, Mackey T, Snell A, Nathaniel T. Ischemic stroke with a preceding Trans ischemic attack (TIA) less than 24 hours and thrombolytic therapy. BMC Neurol. 2020 May 19; 20(1):197.
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Almallouhi E, Ajinkya S, Rahwan M, Holmstedt CA, Al Kasab S. Impact of Stroke Center Certification on Thrombolysis Time Metrics in Telestroke Setting. Telemed J E Health. 2021 02; 27(2):167-171.
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Poupore N, Strat D, Mackey T, Brown K, Snell A, Nathaniel TI. Cholesterol reducer and thrombolytic therapy in acute ischemic stroke patients. Lipids Health Dis. 2020 May 06; 19(1):84.
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Sattur MG, Spiotta AM. Commentary: Efficacy and Safety of Minimally Invasive Surgery With Thrombolysis in Intracerebral Haemorrhage Evacuation (MISTIE III): A Randomized, Controlled, Open-Label, Blinded Endpoint Phase 3 Trial. Neurosurgery. 2020 05 01; 86(5):E444-E446.
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Alawieh AM, Langley EF, Feng W, Spiotta AM, Tomlinson S. Complement-Dependent Synaptic Uptake and Cognitive Decline after Stroke and Reperfusion Therapy. J Neurosci. 2020 05 13; 40(20):4042-4058.
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Simpson AN, Harvey JB, DiLembo SM, Debenham E, Holmstedt CA, Robinson CO, Simpson KN, Almallouhi E, Ford DW. Population Health Indicators Associated with a Statewide Telestroke Program. Telemed J E Health. 2020 09; 26(9):1126-1133.
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Rotimi OR, Ajani IF, Penwell A, Lari S, Walker B, Nathaniel TI. In acute ischemic stroke patients with smoking incidence, are more women than men more likely to be included or excluded from thrombolysis therapy? Womens Health (Lond). 2020 Jan-Dec; 16:1745506520922760.
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Ajinkya S, Almallouhi E, Turner N, Al Kasab S, Holmstedt CA. Racial/Ethnic Disparities in Acute Ischemic Stroke Treatment Within a Telestroke Network. Telemed J E Health. 2020 10; 26(10):1221-1225.
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