 Cocaine
"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
| Descriptor ID |
D003042
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| MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.869.388 D04.075.080.875.099.722.388
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in this website by year, and whether "Cocaine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 5 | 2 | 7 | | 1992 | 2 | 5 | 7 | | 1993 | 13 | 3 | 16 | | 1994 | 8 | 3 | 11 | | 1995 | 13 | 3 | 16 | | 1996 | 12 | 1 | 13 | | 1997 | 10 | 1 | 11 | | 1998 | 7 | 2 | 9 | | 1999 | 7 | 2 | 9 | | 2000 | 3 | 2 | 5 | | 2001 | 6 | 1 | 7 | | 2002 | 9 | 0 | 9 | | 2003 | 11 | 4 | 15 | | 2004 | 3 | 4 | 7 | | 2005 | 9 | 4 | 13 | | 2006 | 13 | 2 | 15 | | 2007 | 11 | 5 | 16 | | 2008 | 16 | 3 | 19 | | 2009 | 8 | 4 | 12 | | 2010 | 13 | 2 | 15 | | 2011 | 11 | 4 | 15 | | 2012 | 11 | 2 | 13 | | 2013 | 17 | 8 | 25 | | 2014 | 13 | 4 | 17 | | 2015 | 6 | 4 | 10 | | 2016 | 7 | 1 | 8 | | 2017 | 14 | 8 | 22 | | 2018 | 8 | 1 | 9 |
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Below are the most recent publications written about "Cocaine" by people in Profiles.
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Kalivas PW. Deconstructing and Reconstructing the Dichotomy That Is Dopamine Receptor-1- and Dopamine Receptor-2-Expressing Neurons. Biol Psychiatry. 2018 12 15; 84(12):862-864.
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Siemsen BM, Giannotti G, McFaddin JA, Scofield MD, McGinty JF. Biphasic effect of abstinence duration following cocaine self-administration on spine morphology and plasticity-related proteins in prelimbic cortical neurons projecting to the nucleus accumbens core. Brain Struct Funct. 2019 Mar; 224(2):741-758.
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Li C, White AC, Schochet T, McGinty JF, Frantz KJ. ARC and BDNF expression after cocaine self-administration or cue-induced reinstatement of cocaine seeking in adolescent and adult male rats. Addict Biol. 2018 11; 23(6):1233-1241.
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Haynes NS, O'Neill CE, Hobson BD, Bachtell RK. Effects of adenosine A2A receptor antagonists on cocaine-induced locomotion and cocaine seeking. Psychopharmacology (Berl). 2019 Feb; 236(2):699-708.
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Giannotti G, Barry SM, Siemsen BM, Peters J, McGinty JF. Divergent Prelimbic Cortical Pathways Interact with BDNF to Regulate Cocaine-seeking. J Neurosci. 2018 10 17; 38(42):8956-8966.
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Roberts-Wolfe D, Bobadilla AC, Heinsbroek JA, Neuhofer D, Kalivas PW. Drug Refraining and Seeking Potentiate Synapses on Distinct Populations of Accumbens Medium Spiny Neurons. J Neurosci. 2018 08 08; 38(32):7100-7107.
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Weber RA, Logan CN, Leong KC, Peris J, Knackstedt L, Reichel CM. Regionally Specific Effects of Oxytocin on Reinstatement of Cocaine Seeking in Male and Female Rats. Int J Neuropsychopharmacol. 2018 07 01; 21(7):677-686.
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Penrod RD, Anderson EM, Cowan CW. Any Way You Splice It: New Molecular Mechanisms of Cocaine-Induced Alternative Gene Expression. Biol Psychiatry. 2018 08 01; 84(3):162-164.
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Gioia DA, Xu M, Wayman WN, Woodward JJ. Effects of drugs of abuse on channelrhodopsin-2 function. Neuropharmacology. 2018 06; 135:316-327.
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Heinsbroek JA, Furbish AB, Peters J. A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse. Neuropsychopharmacology. 2018 06; 43(7):1492-1497.
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