"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
| Descriptor ID |
D003042
|
| MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.084.500.722.388 D03.605.869.388
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in this website by year, and whether "Cocaine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 2 | 5 | 7 |
| 1993 | 13 | 3 | 16 |
| 1994 | 8 | 3 | 11 |
| 1995 | 13 | 3 | 16 |
| 1996 | 12 | 1 | 13 |
| 1997 | 10 | 1 | 11 |
| 1998 | 7 | 2 | 9 |
| 1999 | 7 | 2 | 9 |
| 2000 | 3 | 2 | 5 |
| 2001 | 6 | 1 | 7 |
| 2002 | 9 | 0 | 9 |
| 2003 | 11 | 4 | 15 |
| 2004 | 3 | 4 | 7 |
| 2005 | 9 | 4 | 13 |
| 2006 | 13 | 2 | 15 |
| 2007 | 11 | 5 | 16 |
| 2008 | 16 | 3 | 19 |
| 2009 | 8 | 4 | 12 |
| 2010 | 13 | 2 | 15 |
| 2011 | 11 | 4 | 15 |
| 2012 | 11 | 2 | 13 |
| 2013 | 17 | 8 | 25 |
| 2014 | 13 | 4 | 17 |
| 2015 | 6 | 4 | 10 |
| 2016 | 7 | 1 | 8 |
| 2017 | 14 | 8 | 22 |
| 2018 | 10 | 2 | 12 |
| 2019 | 8 | 3 | 11 |
| 2020 | 4 | 0 | 4 |
| 2021 | 2 | 0 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Cocaine" by people in Profiles.
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Siemsen BM, Scofield MD. Quiet on the Set! Astroglia Star in Silent Synaptogenesis and Cocaine Memory Formation. Biol Psychiatry. 2021 02 15; 89(4):328-330.
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Bartels K, Schacht JP. Cocaine-Positive Patients Undergoing Elective Surgery: From Avoiding Case Cancellations to Treating Substance Use Disorders. Anesth Analg. 2021 02 01; 132(2):305-307.
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Li H, Eid M, Pullmann D, Chao YS, Thomas AA, Jhou TC. Entopeduncular Nucleus Projections to the Lateral Habenula Contribute to Cocaine Avoidance. J Neurosci. 2021 01 13; 41(2):298-306.
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Bobadilla AC, Dereschewitz E, Vaccaro L, Heinsbroek JA, Scofield MD, Kalivas PW. Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core. Mol Psychiatry. 2020 12; 25(12):3150-3163.
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Heinsbroek JA, Bobadilla AC, Dereschewitz E, Assali A, Chalhoub RM, Cowan CW, Kalivas PW. Opposing Regulation of Cocaine Seeking by Glutamate and GABA Neurons in the Ventral Pallidum. Cell Rep. 2020 02 11; 30(6):2018-2027.e3.
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Siemsen BM, McFaddin JA, Haigh K, Brock AG, Nan Leath M, Hooker KN, McGonegal LK, Scofield MD. Amperometric measurements of cocaine cue and novel context-evoked glutamate and nitric oxide release in the nucleus accumbens core. J Neurochem. 2020 06; 153(5):599-616.
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Aksenova M, Sybrandt J, Cui B, Sikirzhytski V, Ji H, Odhiambo D, Lucius MD, Turner JR, Broude E, Peña E, Lizarraga S, Zhu J, Safro I, Wyatt MD, Shtutman M. Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation. J Neuroimmune Pharmacol. 2020 06; 15(2):209-223.
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Pati S, Angel P, Drake RR, Wagner JJ, Cummings BS. Lipidomic changes in the rat hippocampus following cocaine conditioning, extinction, and reinstatement of drug-seeking. Brain Behav. 2019 12; 9(12):e01451.
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Brady KT. Searching for Treatments for Cocaine Use Disorder: The Quest Continues. Am J Psychiatry. 2019 11 01; 176(11):892-893.
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Penrod RD, Thomsen M, Taniguchi M, Guo Y, Cowan CW, Smith LN. The activity-regulated cytoskeleton-associated protein, Arc/Arg3.1, influences mouse cocaine self-administration. Pharmacol Biochem Behav. 2020 01; 188:172818.