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Last Name
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Yusuf A. Hannun

Title
InstitutionMedical University of South Carolina
DepartmentBiochemistry and Molecular Biology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Salama MF, Liu M, Clarke CJ, Espaillat MP, Haley JD, Jin T, Wang D, Obeid LM, Hannun YA. Correction: PKCa is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation. Oncogene. 2019 Nov; 38(48):7366. PMID: 31576014.
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    2. Salama MF, Liu M, Clarke CJ, Espaillat MP, Haley JD, Jin T, Wang D, Obeid LM, Hannun YA. PKCa is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation. Oncogene. 2019 Nov; 38(48):7311-7328. PMID: 31420605.
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    3. Sakamoto W, Canals D, Salamone S, Allopenna J, Clarke CJ, Snider J, Obeid LM, Hannun YA. Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases. J Lipid Res. 2019 Nov; 60(11):1841-1850. PMID: 31243119.
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    4. Bai A, Liu X, Bielawski J, Hannun YA. Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma. PLoS One. 2019; 14(4):e0215770. PMID: 31002723.
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    5. Snider JM, Luberto C, Hannun YA. Approaches for probing and evaluating mammalian sphingolipid metabolism. Anal Biochem. 2019 06 15; 575:70-86. PMID: 30917945.
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    6. Shanbhogue P, Hoffmann RM, Airola MV, Maini R, Hamelin DJ, Garcia-Diaz M, Burke JE, Hannun YA. The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme. J Biol Chem. 2019 05 03; 294(18):7488-7502. PMID: 30890560.
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    7. Schwartz NU, Mileva I, Gurevich M, Snider J, Hannun YA, Obeid LM. Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue. Prostaglandins Other Lipid Mediat. 2019 04; 141:40-48. PMID: 30790665.
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    8. Choi YJ, Laclef C, Yang N, Andreu-Cervera A, Lewis J, Mao X, Li L, Snedecor ER, Takemaru KI, Qin C, Schneider-Maunoury S, Shroyer KR, Hannun YA, Koch PJ, Clark RA, Payne AS, Kowalczyk AP, Chen J. RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis. PLoS Genet. 2019 01; 15(1):e1007914. PMID: 30689641.
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    9. Sahu SK, Hannun YA, Yao N. Emergence of membrane sphingolipids as a potential therapeutic target. Biochimie. 2019 Mar; 158:257-264. PMID: 30703477.
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    10. Snider JM, Trayssac M, Clarke CJ, Schwartz N, Snider AJ, Obeid LM, Luberto C, Hannun YA. Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis. J Lipid Res. 2019 Apr; 60(4):819-831. PMID: 30573560.
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    11. Shanbhogue P, Hannun YA. Exploring the Therapeutic Landscape of Sphingomyelinases. Handb Exp Pharmacol. 2018 Nov 27. PMID: 30478737.
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    12. Bai A, Bielawska A, Rahmaniyan M, Kraveka JM, Bielawski J, Hannun YA. Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites. Bioorg Med Chem. 2018 12 15; 26(23-24):6067-6075. PMID: 30448190.
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    13. Coant N, Hannun YA. Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer. Adv Biol Regul. 2019 01; 71:141-146. PMID: 30389354.
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    14. Hannun YA, Obeid LM. Author Correction: Sphingolipids and their metabolism in physiology and disease. Nat Rev Mol Cell Biol. 2018 Oct; 19(10):673. PMID: 30111875.
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    15. Canals D, Salamone S, Hannun YA. Visualizing bioactive ceramides. Chem Phys Lipids. 2018 11; 216:142-151. PMID: 30266560.
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    16. Ren J, Saied EM, Zhong A, Snider J, Ruiz C, Arenz C, Obeid LM, Girnun GD, Hannun YA. Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway. J Lipid Res. 2018 11; 59(11):2126-2139. PMID: 30154231.
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    17. Sakamoto W, Coant N, Canals D, Obeid LM, Hannun YA. Functions of neutral ceramidase in the Golgi apparatus. J Lipid Res. 2018 11; 59(11):2116-2125. PMID: 30154232.
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    18. Wu S, Zhu W, Thompson P, Hannun YA. Evaluating intrinsic and non-intrinsic cancer risk factors. Nat Commun. 2018 08 28; 9(1):3490. PMID: 30154431.
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    19. Trayssac M, Hannun YA, Obeid LM. Role of sphingolipids in senescence: implication in aging and age-related diseases. J Clin Invest. 2018 07 02; 128(7):2702-2712. PMID: 30108193.
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    20. Newcomb B, Rhein C, Mileva I, Ahmad R, Clarke CJ, Snider J, Obeid LM, Hannun YA. Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5. J Lipid Res. 2018 07; 59(7):1219-1229. PMID: 29724781.
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    21. Coant N, García-Barros M, Zhang Q, Obeid LM, Hannun YA. AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells. Oncogene. 2018 07; 37(28):3852-3863. PMID: 29662189.
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    22. Ahmad R, Al-Roub A, Kochumon S, Akther N, Thomas R, Kumari M, Koshy MS, Tiss A, Hannun YA, Tuomilehto J, Sindhu S, Rosen ED. The Synergy between Palmitate and TNF-a for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation. J Immunol. 2018 05 15; 200(10):3599-3611. PMID: 29632147.
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    23. Snider JM, Snider AJ, Obeid LM, Luberto C, Hannun YA. Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry. J Lipid Res. 2018 06; 59(6):1046-1057. PMID: 29610123.
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    24. Hannun YA. Differentiate and switch, a tale of two heads of a lipid. EMBO J. 2018 04 03; 37(7). PMID: 29572242.
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    25. Rego A, Cooper KF, Snider J, Hannun YA, Costa V, Côrte-Real M, Chaves SR. Acetic acid induces Sch9p-dependent translocation of Isc1p from the endoplasmic reticulum into mitochondria. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jun; 1863(6):576-583. PMID: 29496584.
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    26. Wang K, Xu R, Schrandt J, Shah P, Gong YZ, Preston C, Wang L, Yi JK, Lin CL, Sun W, Spyropoulos DD, Rhee S, Li M, Zhou J, Ge S, Zhang G, Snider AJ, Hannun YA, Obeid LM, Mao C. Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. PLoS Genet. 2018 01; 14(1):e1007190. PMID: 29360825.
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    27. Li F, Xu R, Low BE, Lin CL, Garcia-Barros M, Schrandt J, Mileva I, Snider A, Luo CK, Jiang XC, Li MS, Hannun YA, Obeid LM, Wiles MV, Mao C. Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates. FASEB J. 2018 06; 32(6):3058-3069. PMID: 29401619.
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    28. Pulkoski-Gross MJ, Jenkins ML, Truman JP, Salama MF, Clarke CJ, Burke JE, Hannun YA, Obeid LM. An intrinsic lipid-binding interface controls sphingosine kinase 1 function. J Lipid Res. 2018 03; 59(3):462-474. PMID: 29326159.
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    29. Schwartz NU, Linzer RW, Truman JP, Gurevich M, Hannun YA, Senkal CE, Obeid LM. Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F. FASEB J. 2018 03; 32(3):1716-1728. PMID: 29133339.
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    30. Espaillat MP, Snider AJ, Qiu Z, Channer B, Coant N, Schuchman EH, Kew RR, Sheridan BS, Hannun YA, Obeid LM. Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment. FASEB J. 2018 05; 32(5):2339-2353. PMID: 29259036.
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    31. Xu R, Garcia-Barros M, Wen S, Li F, Lin CL, Hannun YA, Obeid LM, Mao C. Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Cell Death Differ. 2018 05; 25(5):841-856. PMID: 29229990.
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    32. Carroll BL, Bonica J, Shamseddine AA, Hannun YA, Obeid LM. A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway. FEBS Open Bio. 2018 01; 8(1):27-40. PMID: 29321954.
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    33. Furuya H, Tamashiro PM, Shimizu Y, Iino K, Peres R, Chen R, Sun Y, Hannun YA, Obeid LM, Kawamori T. Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis. Carcinogenesis. 2017 12 07; 38(12):1218-1227. PMID: 29028945.
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    34. Morris TG, Borland SJ, Clarke CJ, Wilson C, Hannun YA, Ohanian V, Canfield AE, Ohanian J. Sphingosine 1-phosphate activation of ERM contributes to vascular calcification. J Lipid Res. 2018 01; 59(1):69-78. PMID: 29167409.
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    35. Hannun YA, Obeid LM. Sphingolipids and their metabolism in physiology and disease. Nat Rev Mol Cell Biol. 2018 03; 19(3):175-191. PMID: 29165427.
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    36. Ren J, Snider J, Airola MV, Zhong A, Rana NA, Obeid LM, Hannun YA. Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae. J Lipid Res. 2018 01; 59(1):162-170. PMID: 29092960.
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    37. Lin CL, Xu R, Yi JK, Li F, Chen J, Jones EC, Slutsky JB, Huang L, Rigas B, Cao J, Zhong X, Snider AJ, Obeid LM, Hannun YA, Mao C. Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells. Stem Cell Reports. 2017 11 14; 9(5):1488-1500. PMID: 29056331.
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    38. Vilaça R, Barros I, Matmati N, Silva E, Martins T, Teixeira V, Hannun YA, Costa V. The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1. Biochim Biophys Acta Mol Basis Dis. 2018 Jan; 1864(1):79-88. PMID: 28988886.
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    39. Zhu W, Wu S, Hannun YA. Contributions of the Intrinsic Mutation Process to Cancer Mutation and Risk Burdens. EBioMedicine. 2017 10; 24:5-6. PMID: 28958657.
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    40. Liu M, Clarke CJ, Salama MF, Choi YJ, Obeid LM, Hannun YA. Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation. PLoS One. 2017; 12(9):e0184818. PMID: 28926616.
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    41. Wu S, Zhu W, Hannun YA. Wu et al. reply. Nature. 2017 08 09; 548(7666):E15. PMID: 28796207.
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    42. Wada M, Canals D, Adada M, Coant N, Salama MF, Helke KL, Arthur JS, Shroyer KR, Kitatani K, Obeid LM, Hannun YA. P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment. Oncogene. 2017 11 23; 36(47):6649-6657. PMID: 28783172.
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    43. Airola MV, Shanbhogue P, Shamseddine AA, Guja KE, Senkal CE, Maini R, Bartke N, Wu BX, Obeid LM, Garcia-Diaz M, Hannun YA. Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5549-E5558. PMID: 28652336.
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    44. Bai A, Mao C, Jenkins RW, Szulc ZM, Bielawska A, Hannun YA. Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase. PLoS One. 2017; 12(6):e0177805. PMID: 28614356.
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    45. Dupre TV, Doll MA, Shah PP, Sharp CN, Siow D, Megyesi J, Shayman J, Bielawska A, Bielawski J, Beverly LJ, Hernandez-Corbacho M, Clarke CJ, Snider AJ, Schnellmann RG, Obeid LM, Hannun YA, Siskind LJ. Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury. J Lipid Res. 2017 07; 58(7):1439-1452. PMID: 28490444.
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    46. Pulkoski-Gross MJ, Uys JD, Orr-Gandy KA, Coant N, Bialkowska AB, Szulc ZM, Bai A, Bielawska A, Townsend DM, Hannun YA, Obeid LM, Snider AJ. Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis. Prostaglandins Other Lipid Mediat. 2017 05; 130:47-56. PMID: 28377281.
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    47. Chen JY, Newcomb B, Zhou C, Pondick JV, Ghoshal S, York SR, Motola DL, Coant N, Yi JK, Mao C, Tanabe KK, Bronova I, Berdyshev EV, Fuchs BC, Hannun Y, Chung RT, Mullen AC. Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells. Sci Rep. 2017 03 21; 7:44867. PMID: 28322247.
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    48. Senkal CE, Salama MF, Snider AJ, Allopenna JJ, Rana NA, Koller A, Hannun YA, Obeid LM. Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets. Cell Metab. 2017 03 07; 25(3):686-697. PMID: 28273483.
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    49. Bettiga A, Aureli M, Colciago G, Murdica V, Moschini M, Lucianò R, Canals D, Hannun Y, Hedlund P, Lavorgna G, Colombo R, Bassi R, Samarani M, Montorsi F, Salonia A, Benigni F. Bladder cancer cell growth and motility implicate cannabinoid 2 receptor-mediated modifications of sphingolipids metabolism. Sci Rep. 2017 02 13; 7:42157. PMID: 28191815.
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    50. Begum MA, Shi XX, Tan Y, Zhou WW, Hannun Y, Obeid L, Mao C, Zhu ZR. Molecular Characterization of Rice OsLCB2a1 Gene and Functional Analysis of its Role in Insect Resistance. Front Plant Sci. 2016; 7:1789. PMID: 27990147.
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    51. Coant N, Sakamoto W, Mao C, Hannun YA. Ceramidases, roles in sphingolipid metabolism and in health and disease. Adv Biol Regul. 2017 Jan; 63:122-131. PMID: 27771292.
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    52. Lu S, Cai C, Yan G, Zhou Z, Wan Y, Chen V, Chen L, Cooper GF, Obeid LM, Hannun YA, Lee AV, Lu X. Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations. Cancer Res. 2016 12 01; 76(23):6785-6794. PMID: 27758891.
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    53. García-Barros M, Coant N, Kawamori T, Wada M, Snider AJ, Truman JP, Wu BX, Furuya H, Clarke CJ, Bialkowska AB, Ghaleb A, Yang VW, Obeid LM, Hannun YA. Role of neutral ceramidase in colon cancer. FASEB J. 2016 12; 30(12):4159-4171. PMID: 27609772.
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    54. Yi JK, Xu R, Jeong E, Mileva I, Truman JP, Lin CL, Wang K, Snider J, Wen S, Obeid LM, Hannun YA, Mao C. Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function. Oncotarget. 2016 Apr 19; 7(16):21124-44. PMID: 27008706.
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    55. Carroll BL, Pulkoski-Gross MJ, Hannun YA, Obeid LM. CHK1 regulates NF-?B signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles. Oncotarget. 2016 Apr 05; 7(14):18159-70. PMID: 26921248.
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    56. Xu R, Wang K, Mileva I, Hannun YA, Obeid LM, Mao C. Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response. Oncotarget. 2016 Apr 05; 7(14):18440-57. PMID: 26943039.
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    57. Clarke CJ, Shamseddine AA, Jacob JJ, Khalife G, Burns TA, Hannun YA. ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation. J Lipid Res. 2016 05; 57(5):868-81. PMID: 27013100.
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    58. Wang K, Xu R, Snider AJ, Schrandt J, Li Y, Bialkowska AB, Li M, Zhou J, Hannun YA, Obeid LM, Yang VW, Mao C. Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system. Cell Death Dis. 2016 Mar 03; 7:e2124. PMID: 26938296.
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    59. Wu S, Hannun Y. The importance of extrinsic factors in the development of cancers. Mol Cell Oncol. 2016 May; 3(3):e1143079. PMID: 27314092.
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    60. Chen PW, Fonseca LL, Hannun YA, Voit EO. Analysis of the Involvement of Different Ceramide Variants in the Response to Hydroxyurea Stress in Baker's Yeast. PLoS One. 2016; 11(1):e0146839. PMID: 26784947.
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    61. Sundaram K, Mather AR, Marimuthu S, Shah PP, Snider AJ, Obeid LM, Hannun YA, Beverly LJ, Siskind LJ. Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. Biochem J. 2016 Mar 15; 473(6):743-55. PMID: 26747710.
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    62. Snider AJ, Bialkowska AB, Ghaleb AM, Yang VW, Obeid LM, Hannun YA. Murine Model for Colitis-Associated Cancer of the Colon. Methods Mol Biol. 2016; 1438:245-54. PMID: 27150094.
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    63. Matmati N, Kitagaki H, Hannun YA. New role for ceramide in the pheromone response. Cell Cycle. 2016; 15(5):617-8. PMID: 26822556.
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    64. Wu S, Powers S, Zhu W, Hannun YA. Substantial contribution of extrinsic risk factors to cancer development. Nature. 2016 Jan 07; 529(7584):43-7. PMID: 26675728.
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    65. Shamseddine AA, Clarke CJ, Carroll B, Airola MV, Mohammed S, Rella A, Obeid LM, Hannun YA. P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest. Cell Death Dis. 2015 Oct 29; 6:e1947. PMID: 26512957.
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    66. Wang K, Xu R, Schrandt J, Shah P, Gong YZ, Preston C, Wang L, Yi JK, Lin CL, Sun W, Spyropoulos DD, Rhee S, Li M, Zhou J, Ge S, Zhang G, Snider AJ, Hannun YA, Obeid LM, Mao C. Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. PLoS Genet. 2015 Oct; 11(10):e1005591. PMID: 26474409.
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    67. Zhao L, Spassieva S, Gable K, Gupta SD, Shi LY, Wang J, Bielawski J, Hicks WL, Krebs MP, Naggert J, Hannun YA, Dunn TM, Nishina PM. Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):12962-7. PMID: 26438849.
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    68. Kitatani K, Usui T, Sriraman SK, Toyoshima M, Ishibashi M, Shigeta S, Nagase S, Sakamoto M, Ogiso H, Okazaki T, Hannun YA, Torchilin VP, Yaegashi N. Ceramide limits phosphatidylinositol-3-kinase C2ß-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid. Oncogene. 2016 05; 35(21):2801-12. PMID: 26364609.
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    69. Hernández-Corbacho MJ, Canals D, Adada MM, Liu M, Senkal CE, Yi JK, Mao C, Luberto C, Hannun YA, Obeid LM. Tumor Necrosis Factor-a (TNFa)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death. J Biol Chem. 2015 Oct 16; 290(42):25356-73. PMID: 26318452.
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    70. Kitatani K, Wada M, Perry D, Usui T, Sun Y, Obeid LM, Yaegashi N, Grabowski GA, Hannun YA. Activation of p38 Mitogen-Activated Protein Kinase in Gaucher's Disease. PLoS One. 2015; 10(8):e0136633. PMID: 26312487.
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    71. Casasampere M, Camacho L, Cingolani F, Casas J, Egido-Gabás M, Abad JL, Bedia C, Xu R, Wang K, Canals D, Hannun YA, Mao C, Fabrias G. Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols. J Lipid Res. 2015 Oct; 56(10):2019-28. PMID: 26286360.
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    72. Chen PW, Fonseca LL, Hannun YA, Voit EO. Dynamics of the Heat Stress Response of Ceramides with Different Fatty-Acyl Chain Lengths in Baker's Yeast. PLoS Comput Biol. 2015 Aug; 11(8):e1004373. PMID: 26241868.
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    73. Adada MM, Canals D, Jeong N, Kelkar AD, Hernandez-Corbacho M, Pulkoski-Gross MJ, Donaldson JC, Hannun YA, Obeid LM. Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion. FASEB J. 2015 Nov; 29(11):4654-69. PMID: 26209696.
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    74. Airola MV, Allen WJ, Pulkoski-Gross MJ, Obeid LM, Rizzo RC, Hannun YA. Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. Structure. 2015 Aug 04; 23(8):1482-1491. PMID: 26190575.
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    75. Wu BX, Fan J, Boyer NP, Jenkins RW, Koutalos Y, Hannun YA, Crosson CE. Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration. PLoS One. 2015; 10(7):e0133032. PMID: 26168297.
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    76. Ghaleb AM, Bialkowska AB, Snider AJ, Gnatenko DV, Hannun YA, Yang VW, Schmidt VA. IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice. PLoS One. 2015; 10(6):e0129314. PMID: 26047140.
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    77. Hannun YA, Newcomb B. A new twist to the emerging functions of ceramides in cancer: novel role for platelet acid sphingomyelinase in cancer metastasis. EMBO Mol Med. 2015 Jun; 7(6):692-4. PMID: 25859016.
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    78. Salama MF, Carroll B, Adada M, Pulkoski-Gross M, Hannun YA, Obeid LM. A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma. FASEB J. 2015 Jul; 29(7):2803-13. PMID: 25805832.
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    79. Lu Z, Li Y, Jin J, Zhang X, Hannun YA, Huang Y. GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS. Atherosclerosis. 2015 May; 240(1):163-73. PMID: 25795558.
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    80. Rajagopalan V, Canals D, Luberto C, Snider J, Voelkel-Johnson C, Obeid LM, Hannun YA. Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization. Biochim Biophys Acta. 2015 Apr; 1850(4):628-39. PMID: 25484313.
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    81. Snider AJ, Ali WH, Sticca JA, Coant N, Ghaleb AM, Kawamori T, Yang VW, Hannun YA, Obeid LM. Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease. PLoS One. 2014; 9(12):e113998. PMID: 25460165.
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    82. Rachidi S, Sun S, Wu BX, Jones E, Drake RR, Ogretmen B, Cowart LA, Clarke CJ, Hannun YA, Chiosis G, Liu B, Li Z. Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. J Hepatol. 2015 Apr; 62(4):879-88. PMID: 25463537.
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    83. Shamseddine AA, Airola MV, Hannun YA. Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes. Adv Biol Regul. 2015 Jan; 57:24-41. PMID: 25465297.
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    84. Bai A, Szulc ZM, Bielawski J, Pierce JS, Rembiesa B, Terzieva S, Mao C, Xu R, Wu B, Clarke CJ, Newcomb B, Liu X, Norris J, Hannun YA, Bielawska A. Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorg Med Chem. 2014 Dec 15; 22(24):6933-44. PMID: 25456083.
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    85. Robinson KA, Hegyi K, Hannun YA, Buse MG, Sethi JK. Go-6976 reverses hyperglycemia-induced insulin resistance independently of cPKC inhibition in adipocytes. PLoS One. 2014; 9(10):e108963. PMID: 25330241.
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    86. Airola MV, Tumolo JM, Snider J, Hannun YA. Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide. PLoS One. 2014; 9(8):e105830. PMID: 25144372.
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    87. Jones EE, Dworski S, Canals D, Casas J, Fabrias G, Schoenling D, Levade T, Denlinger C, Hannun YA, Medin JA, Drake RR. On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem. 2014 Aug 19; 86(16):8303-11. PMID: 25072097.
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    93. Wei J, Ferron M, Clarke CJ, Hannun YA, Jiang H, Blaner WS, Karsenty G. Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. J Clin Invest. 2014 Apr; 124(4):1-13. PMID: 24642469.
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    94. Spincemaille P, Chandhok G, Newcomb B, Verbeek J, Vriens K, Zibert A, Schmidt H, Hannun YA, van Pelt J, Cassiman D, Cammue BPA, Thevissen K. The plant decapeptide OSIP108 prevents copper-induced apoptosis in yeast and human cells. Biochim Biophys Acta. 2014 Jun; 1843(6):1207-1215. PMID: 24632503.
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    95. Truman JP, García-Barros M, Obeid LM, Hannun YA. Evolving concepts in cancer therapy through targeting sphingolipid metabolism. Biochim Biophys Acta. 2014 Aug; 1841(8):1174-88. PMID: 24384461.
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    96. Vilaça R, Silva E, Nadais A, Teixeira V, Matmati N, Gaifem J, Hannun YA, Sá Miranda MC, Costa V. Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1. Mol Microbiol. 2014 Feb; 91(3):438-51. PMID: 24286211.
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    97. Liu M, Idkowiak-Baldys J, Roddy PL, Baldys A, Raymond J, Clarke CJ, Hannun YA. Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor. PLoS One. 2013; 8(11):e80721. PMID: 24244711.
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    98. Montefusco DJ, Matmati N, Hannun YA. The yeast sphingolipid signaling landscape. Chem Phys Lipids. 2014 Jan; 177:26-40. PMID: 24220500.
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    99. Swinnen E, Wilms T, Idkowiak-Baldys J, Smets B, De Snijder P, Accardo S, Ghillebert R, Thevissen K, Cammue B, De Vos D, Bielawski J, Hannun YA, Winderickx J. The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. Mol Biol Cell. 2014 Jan; 25(1):196-211. PMID: 24196832.
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    100. Montefusco DJ, Chen L, Matmati N, Lu S, Newcomb B, Cooper GF, Hannun YA, Lu X. Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and systems biology analyses. Sci Signal. 2013 Oct 29; 6(299):rs14. PMID: 24170935.
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    101. El Osta M, Liu M, Adada M, Senkal CE, Idkowiak-Baldys J, Obeid LM, Clarke CJ, Hannun YA. Sustained PKCßII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner. FASEB J. 2014 Jan; 28(1):495-505. PMID: 24121461.
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    102. García-Barros M, Coant N, Truman JP, Snider AJ, Hannun YA. Sphingolipids in colon cancer. Biochim Biophys Acta. 2014 May; 1841(5):773-82. PMID: 24060581.
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    103. Jenkins RW, Clarke CJ, Lucas JT, Shabbir M, Wu BX, Simbari F, Mueller J, Hannun YA, Lazarchick J, Shirai K. Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis. Am J Hematol. 2013 Nov; 88(11):E265-72. PMID: 23828274.
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    105. Adada MM, Orr-Gandy KA, Snider AJ, Canals D, Hannun YA, Obeid LM, Clarke CJ. Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor ?B activation. J Biol Chem. 2013 Sep 20; 288(38):27667-79. PMID: 23935096.
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    106. Jin J, Zhang X, Lu Z, Perry DM, Li Y, Russo SB, Cowart LA, Hannun YA, Huang Y. Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages. Am J Physiol Endocrinol Metab. 2013 Oct 01; 305(7):E853-67. PMID: 23921144.
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    108. Chen PW, Fonseca LL, Hannun YA, Voit EO. Coordination of rapid sphingolipid responses to heat stress in yeast. PLoS Comput Biol. 2013; 9(5):e1003078. PMID: 23737740.
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    109. Kajimura D, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B, Clarke CJ, Hannun YA, DePinho RA, Guo XE, Guo EX, Mann JJ, Karsenty G. Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab. 2013 Jun 04; 17(6):901-15. PMID: 23684624.
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    110. Cinq-Frais C, Coatrieux C, Grazide MH, Hannun YA, Nègre-Salvayre A, Salvayre R, Augé N. A signaling cascade mediated by ceramide, src and PDGFRß coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Biochim Biophys Acta. 2013 Aug; 1831(8):1344-56. PMID: 23651497.
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    111. Orr Gandy KA, Adada M, Canals D, Carroll B, Roddy P, Hannun YA, Obeid LM. Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. FASEB J. 2013 Aug; 27(8):3155-66. PMID: 23629860.
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    113. Gandy KA, Canals D, Adada M, Wada M, Roddy P, Snider AJ, Hannun YA, Obeid LM. Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. Biochem J. 2013 Feb 01; 449(3):661-72. PMID: 23106337.
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    117. Furuya H, Wada M, Shimizu Y, Yamada PM, Hannun YA, Obeid LM, Kawamori T. Effect of sphingosine kinase 1 inhibition on blood pressure. FASEB J. 2013 Feb; 27(2):656-64. PMID: 23109673.
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    120. Gault CR, Eblen ST, Neumann CA, Hannun YA, Obeid LM. Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner. J Biol Chem. 2012 Sep 14; 287(38):31794-803. PMID: 22833671.
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    121. Sewell GW, Hannun YA, Han X, Koster G, Bielawski J, Goss V, Smith PJ, Rahman FZ, Vega R, Bloom SL, Walker AP, Postle AD, Segal AW. Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition. Int J Biochem Cell Biol. 2012 Nov; 44(11):1839-46. PMID: 22728312.
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    123. Truman JP, Al Gadban MM, Smith KJ, Jenkins RW, Mayroo N, Virella G, Lopes-Virella MF, Bielawska A, Hannun YA, Hammad SM. Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release. Immunology. 2012 May; 136(1):30-45. PMID: 22236141.
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    124. Meyers-Needham M, Lewis JA, Gencer S, Sentelle RD, Saddoughi SA, Clarke CJ, Hannun YA, Norell H, da Palma TM, Nishimura M, Kraveka JM, Khavandgar Z, Murshed M, Cevik MO, Ogretmen B. Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Mol Cancer Ther. 2012 May; 11(5):1092-102. PMID: 22452947.
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    125. Beckham TH, Lu P, Cheng JC, Zhao D, Turner LS, Zhang X, Hoffman S, Armeson KE, Liu A, Marrison T, Hannun YA, Liu X. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int J Cancer. 2012 Nov 01; 131(9):2034-43. PMID: 22322590.
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    126. Apraiz A, Idkowiak-Baldys J, Nieto-Rementería N, Boyano MD, Hannun YA, Asumendi A. Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death. Biochem Cell Biol. 2012 Apr; 90(2):209-23. PMID: 22428532.
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    127. Thevissen K, de Mello Tavares P, Xu D, Blankenship J, Vandenbosch D, Idkowiak-Baldys J, Govaert G, Bink A, Rozental S, de Groot PW, Davis TR, Kumamoto CA, Vargas G, Nimrichter L, Coenye T, Mitchell A, Roemer T, Hannun YA, Cammue BP. The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans. Mol Microbiol. 2012 Apr; 84(1):166-80. PMID: 22384976.
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    133. Apraiz A, Idkowiak-Baldys JK, Boyano MD, Pérez-Yarza G, Hannun YA, Asumendi A. Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells. BMC Cancer. 2011 Nov 07; 11:477. PMID: 22061047.
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    134. Tripathi K, Matmati N, Zheng WJ, Hannun YA, Mohanty BK. Cellular morphogenesis under stress is influenced by the sphingolipid pathway gene ISC1 and DNA integrity checkpoint genes in Saccharomyces cerevisiae. Genetics. 2011 Oct; 189(2):533-47. PMID: 21840863.
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    135. Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, Ogretmen B. Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C18-ceramide as a novel biomarker for monitoring response. Clin Cancer Res. 2011 Sep 15; 17(18):6097-105. PMID: 21791630.
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    136. Khavandgar Z, Poirier C, Clarke CJ, Li J, Wang N, McKee MD, Hannun YA, Murshed M. A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization. J Cell Biol. 2011 Jul 25; 194(2):277-89. PMID: 21788370.
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    137. Heffernan-Stroud LA, Helke KL, Jenkins RW, De Costa AM, Hannun YA, Obeid LM. Defining a role for sphingosine kinase 1 in p53-dependent tumors. Oncogene. 2012 Mar 01; 31(9):1166-75. PMID: 21765468.
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    138. Barbosa AD, Osório H, Sims KJ, Almeida T, Alves M, Bielawski J, Amorim MA, Moradas-Ferreira P, Hannun YA, Costa V. Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells. Mol Microbiol. 2011 Jul; 81(2):515-27. PMID: 21707788.
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    142. Novgorodov SA, Wu BX, Gudz TI, Bielawski J, Ovchinnikova TV, Hannun YA, Obeid LM. Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. J Biol Chem. 2011 Jul 15; 286(28):25352-62. PMID: 21613224.
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    143. Zhao L, Spassieva SD, Jucius TJ, Shultz LD, Shick HE, Macklin WB, Hannun YA, Obeid LM, Ackerman SL. A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet. 2011 May; 7(5):e1002063. PMID: 21625621.
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    145. Rahmaniyan M, Curley RW, Obeid LM, Hannun YA, Kraveka JM. Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide. J Biol Chem. 2011 Jul 15; 286(28):24754-64. PMID: 21543327.
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    147. Sun Y, Ran H, Liou B, Quinn B, Zamzow M, Zhang W, Bielawski J, Kitatani K, Setchell KD, Hannun YA, Grabowski GA. Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse. PLoS One. 2011 Apr 20; 6(4):e19037. PMID: 21533102.
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    148. Clarke CJ, Cloessner EA, Roddy PL, Hannun YA. Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-a in MCF-7 cells. Biochem J. 2011 Apr 15; 435(2):381-90. PMID: 21303347.
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    149. El-Osta MA, Idkowiak-Baldys J, Hannun YA. Delayed phosphorylation of classical protein kinase C (PKC) substrates requires PKC internalization and formation of the pericentrion in a phospholipase D (PLD)-dependent manner. J Biol Chem. 2011 Jun 03; 286(22):19340-53. PMID: 21478146.
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    150. Mullen TD, Jenkins RW, Clarke CJ, Bielawski J, Hannun YA, Obeid LM. Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. J Biol Chem. 2011 May 06; 286(18):15929-42. PMID: 21388949.
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    151. Jenkins RW, Clarke CJ, Canals D, Snider AJ, Gault CR, Heffernan-Stroud L, Wu BX, Simbari F, Roddy P, Kitatani K, Obeid LM, Hannun YA. Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J Biol Chem. 2011 Apr 15; 286(15):13292-303. PMID: 21335555.
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    152. Thayyullathil F, Chathoth S, Hago A, Patel M, Szulc ZM, Hannun Y, Galadari S. Purification and characterization of a second type of neutral ceramidase from rat brain: a second more hydrophobic form of rat brain ceramidase. Biochim Biophys Acta. 2011 Apr; 1811(4):242-52. PMID: 21224012.
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    153. Shirai K, Kaneshiro T, Wada M, Furuya H, Bielawski J, Hannun YA, Obeid LM, Ogretmen B, Kawamori T. A role of sphingosine kinase 1 in head and neck carcinogenesis. Cancer Prev Res (Phila). 2011 Mar; 4(3):454-62. PMID: 21209394.
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    155. Hou Q, Jin J, Zhou H, Novgorodov SA, Bielawska A, Szulc ZM, Hannun YA, Obeid LM, Hsu YT. Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis. J Lipid Res. 2011 Feb; 52(2):278-88. PMID: 21081756.
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    156. Clarke CJ, Wu BX, Hannun YA. The neutral sphingomyelinase family: identifying biochemical connections. Adv Enzyme Regul. 2011; 51(1):51-8. PMID: 21035485.
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    157. Mullen TD, Spassieva S, Jenkins RW, Kitatani K, Bielawski J, Hannun YA, Obeid LM. Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism. J Lipid Res. 2011 Jan; 52(1):68-77. PMID: 20940143.
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    158. Cowart LA, Gandy JL, Tholanikunnel B, Hannun YA. Sphingolipids mediate formation of mRNA processing bodies during the heat-stress response of Saccharomyces cerevisiae. Biochem J. 2010 Oct 01; 431(1):31-8. PMID: 20629639.
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    159. Szulc ZM, Bai A, Bielawski J, Mayroo N, Miller DE, Gracz H, Hannun YA, Bielawska A. Synthesis, NMR characterization and divergent biological actions of 2'-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells. Bioorg Med Chem. 2010 Nov 01; 18(21):7565-79. PMID: 20851613.
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    160. An D, Na C, Bielawski J, Hannun YA, Kasper DL. Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine. Proc Natl Acad Sci U S A. 2011 Mar 15; 108 Suppl 1:4666-71. PMID: 20855611.
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    162. Milhas D, Clarke CJ, Idkowiak-Baldys J, Canals D, Hannun YA. Anterograde and retrograde transport of neutral sphingomyelinase-2 between the Golgi and the plasma membrane. Biochim Biophys Acta. 2010 Dec; 1801(12):1361-74. PMID: 20713176.
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    163. Canals D, Jenkins RW, Roddy P, Hernández-Corbacho MJ, Obeid LM, Hannun YA. Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. J Biol Chem. 2010 Oct 15; 285(42):32476-85. PMID: 20679347.
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    164. Hammad SM, Pierce JS, Soodavar F, Smith KJ, Al Gadban MM, Rembiesa B, Klein RL, Hannun YA, Bielawski J, Bielawska A. Blood sphingolipidomics in healthy humans: impact of sample collection methodology. J Lipid Res. 2010 Oct; 51(10):3074-87. PMID: 20660127.
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    167. Uchida Y, Houben E, Park K, Douangpanya S, Lee YM, Wu BX, Hannun YA, Radin NS, Elias PM, Holleran WM. Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB. J Invest Dermatol. 2010 Oct; 130(10):2472-80. PMID: 20520628.
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    168. Wu BX, Rajagopalan V, Roddy PL, Clarke CJ, Hannun YA. Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5. J Biol Chem. 2010 Jun 04; 285(23):17993-8002. PMID: 20378533.
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    170. Devillard R, Galvani S, Thiers JC, Guenet JL, Hannun Y, Bielawski J, Nègre-Salvayre A, Salvayre R, Augé N. Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation. PLoS One. 2010 Mar 23; 5(3):e9826. PMID: 20352118.
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    171. Cowart LA, Shotwell M, Worley ML, Richards AJ, Montefusco DJ, Hannun YA, Lu X. Revealing a signaling role of phytosphingosine-1-phosphate in yeast. Mol Syst Biol. 2010; 6:349. PMID: 20160710.
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    172. Matmati K, Matmati N, Hannun YA, Rumboldt Z, Patel S, Lazarchick J, Stuart R, Giglio P. Dural MALT lymphoma with disseminated disease. Hematol Rep. 2010 Jan 26; 2(1):e10. PMID: 22184513.
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    173. Sun Y, Liou B, Ran H, Skelton MR, Williams MT, Vorhees CV, Kitatani K, Hannun YA, Witte DP, Xu YH, Grabowski GA. Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. Hum Mol Genet. 2010 Mar 15; 19(6):1088-97. PMID: 20047948.
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    183. Gustafsson K, Sander B, Bielawski J, Hannun YA, Flygare J. Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism. Mol Cancer Res. 2009 Jul; 7(7):1086-98. PMID: 19609004.
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    184. Jin J, Mullen TD, Hou Q, Bielawski J, Bielawska A, Zhang X, Obeid LM, Hannun YA, Hsu YT. AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J Lipid Res. 2009 Dec; 50(12):2389-97. PMID: 19528633.
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    192. Bai A, Szulc ZM, Bielawski J, Mayroo N, Liu X, Norris J, Hannun YA, Bielawska A. Synthesis and bioevaluation of omega-N-amino analogs of B13. Bioorg Med Chem. 2009 Mar 01; 17(5):1840-8. PMID: 19217788.
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    193. Kitagaki H, Cowart LA, Matmati N, Montefusco D, Gandy J, de Avalos SV, Novgorodov SA, Zheng J, Obeid LM, Hannun YA. ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae. J Biol Chem. 2009 Apr 17; 284(16):10818-30. PMID: 19179331.
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    194. Yu H, Zeidan YH, Wu BX, Jenkins RW, Flotte TR, Hannun YA, Virella-Lowell I. Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis. Am J Respir Cell Mol Biol. 2009 Sep; 41(3):367-75. PMID: 19168701.
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    196. Mahdy AE, Cheng JC, Li J, Elojeimy S, Meacham WD, Turner LS, Bai A, Gault CR, McPherson AS, Garcia N, Beckham TH, Saad A, Bielawska A, Bielawski J, Hannun YA, Keane TE, Taha MI, Hammouda HM, Norris JS, Liu X. Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol Ther. 2009 Mar; 17(3):430-8. PMID: 19107118.
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    197. Villa NY, Kupchak BR, Garitaonandia I, Smith JL, Alonso E, Alford C, Cowart LA, Hannun YA, Lyons TJ. Sphingolipids function as downstream effectors of a fungal PAQR. Mol Pharmacol. 2009 Apr; 75(4):866-75. PMID: 19066337.
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    198. Mukhopadhyay A, Saddoughi SA, Song P, Sultan I, Ponnusamy S, Senkal CE, Snook CF, Arnold HK, Sears RC, Hannun YA, Ogretmen B. Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. FASEB J. 2009 Mar; 23(3):751-63. PMID: 19028839.
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    201. Kawamori T, Kaneshiro T, Okumura M, Maalouf S, Uflacker A, Bielawski J, Hannun YA, Obeid LM. Role for sphingosine kinase 1 in colon carcinogenesis. FASEB J. 2009 Feb; 23(2):405-14. PMID: 18824518.
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    202. Snider AJ, Kawamori T, Bradshaw SG, Orr KA, Gilkeson GS, Hannun YA, Obeid LM. A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. FASEB J. 2009 Jan; 23(1):143-52. PMID: 18815359.
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    203. Nahas Z, Jiang Y, Zeidan YH, Bielawska A, Szulc Z, Devane L, Kalivas P, Hannun YA. Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats. Behav Brain Res. 2009 Jan 30; 197(1):41-4. PMID: 18768150.
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    204. Chudakova DA, Zeidan YH, Wheeler BW, Yu J, Novgorodov SA, Kindy MS, Hannun YA, Gudz TI. Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity. J Biol Chem. 2008 Oct 24; 283(43):28806-16. PMID: 18682390.
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    214. Panjarian S, Kozhaya L, Arayssi S, Yehia M, Bielawski J, Bielawska A, Usta J, Hannun YA, Obeid LM, Dbaibo GS. De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. Prostaglandins Other Lipid Mediat. 2008 Jun; 86(1-4):41-8. PMID: 18400537.
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    264. Dindo D, Dahm F, Szulc Z, Bielawska A, Obeid LM, Hannun YA, Graf R, Clavien PA. Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. Mol Cancer Ther. 2006 Jun; 5(6):1520-9. PMID: 16818511.
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    265. Taha TA, Hannun YA, Obeid LM. Sphingosine kinase: biochemical and cellular regulation and role in disease. J Biochem Mol Biol. 2006 Mar 31; 39(2):113-31. PMID: 16584625.
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    266. Senkal CE, Ponnusamy S, Rossi MJ, Sundararaj K, Szulc Z, Bielawski J, Bielawska A, Meyer M, Cobanoglu B, Koybasi S, Sinha D, Day TA, Obeid LM, Hannun YA, Ogretmen B. Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. J Pharmacol Exp Ther. 2006 Jun; 317(3):1188-99. PMID: 16510697.
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    267. Cowart LA, Okamoto Y, Lu X, Hannun YA. Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae. Biochem J. 2006 Feb 01; 393(Pt 3):733-40. PMID: 16201964.
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    268. Galadari S, Wu BX, Mao C, Roddy P, El Bawab S, Hannun YA. Identification of a novel amidase motif in neutral ceramidase. Biochem J. 2006 Feb 01; 393(Pt 3):687-95. PMID: 16229686.
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    269. Sultan I, Senkal CE, Ponnusamy S, Bielawski J, Szulc Z, Bielawska A, Hannun YA, Ogretmen B. Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. Biochem J. 2006 Jan 15; 393(Pt 2):513-21. PMID: 16201965.
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    270. Taha TA, Kitatani K, El-Alwani M, Bielawski J, Hannun YA, Obeid LM. Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J. 2006 Mar; 20(3):482-4. PMID: 16507765.
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    271. Kono M, Dreier JL, Ellis JM, Allende ML, Kalkofen DN, Sanders KM, Bielawski J, Bielawska A, Hannun YA, Proia RL. Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. J Biol Chem. 2006 Mar 17; 281(11):7324-31. PMID: 16380386.
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    272. Osawa Y, Hannun YA, Proia RL, Brenner DA. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Hepatology. 2005 Dec; 42(6):1320-8. PMID: 16317686.
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    273. Kawamori T, Osta W, Johnson KR, Pettus BJ, Bielawski J, Tanaka T, Wargovich MJ, Reddy BS, Hannun YA, Obeid LM, Zhou D. Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J. 2006 Feb; 20(2):386-8. PMID: 16319132.
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    274. Bu S, Yamanaka M, Pei H, Bielawska A, Bielawski J, Hannun YA, Obeid L, Trojanowska M. Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. FASEB J. 2006 Jan; 20(1):184-6. PMID: 16278291.
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    275. Cowart LA, Hannun YA. Using genomic and lipidomic strategies to investigate sphingolipid function in the yeast heat-stress response. Biochem Soc Trans. 2005 Nov; 33(Pt 5):1166-9. PMID: 16246073.
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    276. Jones JA, Rawles R, Hannun YA. Identification of a novel phosphatidic acid binding domain in protein phosphatase-1. Biochemistry. 2005 Oct 11; 44(40):13235-45. PMID: 16201749.
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    277. Voelkel-Johnson C, Hannun YA, El-Zawahry A. Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. Mol Cancer Ther. 2005 Sep; 4(9):1320-7. PMID: 16170023.
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    278. Becker KP, Hannun YA. Protein kinase C and phospholipase D: intimate interactions in intracellular signaling. Cell Mol Life Sci. 2005 Jul; 62(13):1448-61. PMID: 15924269.
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    279. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005 Jul 29; 280(30):27879-87. PMID: 15946935.
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    280. Pettus BJ, Kitatani K, Chalfant CE, Taha TA, Kawamori T, Bielawski J, Obeid LM, Hannun YA. The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol Pharmacol. 2005 Aug; 68(2):330-5. PMID: 15900018.
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    281. Birbes H, Luberto C, Hsu YT, El Bawab S, Hannun YA, Obeid LM. A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. Biochem J. 2005 Mar 15; 386(Pt 3):445-51. PMID: 15516208.
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    282. Novgorodov SA, Szulc ZM, Luberto C, Jones JA, Bielawski J, Bielawska A, Hannun YA, Obeid LM. Positively charged ceramide is a potent inducer of mitochondrial permeabilization. J Biol Chem. 2005 Apr 22; 280(16):16096-105. PMID: 15722351.
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    283. Taha TA, Kitatani K, Bielawski J, Cho W, Hannun YA, Obeid LM. Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. J Biol Chem. 2005 Apr 29; 280(17):17196-202. PMID: 15710602.
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    284. Alvarez-Vasquez F, Sims KJ, Cowart LA, Okamoto Y, Voit EO, Hannun YA. Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae. Nature. 2005 Jan 27; 433(7024):425-30. PMID: 15674294.
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    285. Hu W, Xu R, Zhang G, Jin J, Szulc ZM, Bielawski J, Hannun YA, Obeid LM, Mao C. Golgi fragmentation is associated with ceramide-induced cellular effects. Mol Biol Cell. 2005 Mar; 16(3):1555-67. PMID: 15647381.
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    286. Rossi MJ, Sundararaj K, Koybasi S, Phillips MS, Szulc ZM, Bielawska A, Day TA, Obeid LM, Hannun YA, Ogretmen B. Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngol Head Neck Surg. 2005 Jan; 132(1):55-62. PMID: 15632910.
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    287. Vaena de Avalos S, Su X, Zhang M, Okamoto Y, Dowhan W, Hannun YA. The phosphatidylglycerol/cardiolipin biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces cerevisiae. J Biol Chem. 2005 Feb 25; 280(8):7170-7. PMID: 15611094.
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    288. Becker KP, Kitatani K, Idkowiak-Baldys J, Bielawski J, Hannun YA. Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. J Biol Chem. 2005 Jan 28; 280(4):2606-12. PMID: 15546881.
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    289. Pinto FR, Cowart LA, Hannun YA, Rohrer B, Almeida JS. Local correlation of expression profiles with gene annotations--proof of concept for a general conciliatory method. Bioinformatics. 2005 Apr 01; 21(7):1037-45. PMID: 15509607.
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    290. Yamanaka M, Shegogue D, Pei H, Bu S, Bielawska A, Bielawski J, Pettus B, Hannun YA, Obeid L, Trojanowska M. Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. J Biol Chem. 2004 Dec 24; 279(52):53994-4001. PMID: 15485866.
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    291. Koybasi S, Senkal CE, Sundararaj K, Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM, Hannun YA, Obeid LM, Ogretmen B. Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem. 2004 Oct 22; 279(43):44311-9. PMID: 15317812.
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    292. Osta WA, Chen Y, Mikhitarian K, Mitas M, Salem M, Hannun YA, Cole DJ, Gillanders WE. EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res. 2004 Aug 15; 64(16):5818-24. PMID: 15313925.
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    293. Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer. 2004 Aug; 4(8):604-16. PMID: 15286740.
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    294. Futerman AH, Hannun YA. The complex life of simple sphingolipids. EMBO Rep. 2004 Aug; 5(8):777-82. PMID: 15289826.
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    295. Pettus BJ, Chalfant CE, Hannun YA. Sphingolipids in inflammation: roles and implications. Curr Mol Med. 2004 Jun; 4(4):405-18. PMID: 15354871.
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    296. Becker KP, Hannun YA. Isoenzyme-specific translocation of protein kinase C (PKC)betaII and not PKCbetaI to a juxtanuclear subset of recycling endosomes: involvement of phospholipase D. J Biol Chem. 2004 Jul 02; 279(27):28251-6. PMID: 15067001.
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    297. Marchesini N, Osta W, Bielawski J, Luberto C, Obeid LM, Hannun YA. Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. J Biol Chem. 2004 Jun 11; 279(24):25101-11. PMID: 15051724.
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    298. Heung LJ, Luberto C, Plowden A, Hannun YA, Del Poeta M. The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans. J Biol Chem. 2004 May 14; 279(20):21144-53. PMID: 15014071.
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    299. Taha TA, Osta W, Kozhaya L, Bielawski J, Johnson KR, Gillanders WE, Dbaibo GS, Hannun YA, Obeid LM. Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. J Biol Chem. 2004 May 07; 279(19):20546-54. PMID: 14988393.
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    300. Hannun YA, Luberto C. Lipid metabolism: ceramide transfer protein adds a new dimension. Curr Biol. 2004 Feb 17; 14(4):R163-5. PMID: 15027471.
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    301. Bai A, Meier GP, Wang Y, Luberto C, Hannun YA, Zhou D. Prodrug modification increases potassium tricyclo[5.2.1.0(2,6)]-decan-8-yl dithiocarbonate (D609) chemical stability and cytotoxicity against U937 leukemia cells. J Pharmacol Exp Ther. 2004 Jun; 309(3):1051-9. PMID: 14960662.
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    302. Alvarez-Vasquez F, Sims KJ, Hannun YA, Voit EO. Integration of kinetic information on yeast sphingolipid metabolism in dynamical pathway models. J Theor Biol. 2004 Feb 07; 226(3):265-91. PMID: 14643642.
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    303. Marchesini N, Hannun YA. Acid and neutral sphingomyelinases: roles and mechanisms of regulation. Biochem Cell Biol. 2004 Feb; 82(1):27-44. PMID: 15052326.
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    304. Meng A, Luberto C, Meier P, Bai A, Yang X, Hannun YA, Zhou D. Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. Exp Cell Res. 2004 Jan 15; 292(2):385-92. PMID: 14697345.
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    305. Pettus BJ, Baes M, Busman M, Hannun YA, Van Veldhoven PP. Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders. Rapid Commun Mass Spectrom. 2004; 18(14):1569-74. PMID: 15282781.
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    306. Pettus BJ, Kroesen BJ, Szulc ZM, Bielawska A, Bielawski J, Hannun YA, Busman M. Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry. Rapid Commun Mass Spectrom. 2004; 18(5):577-83. PMID: 14978803.
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    307. Vaena de Avalos S, Okamoto Y, Hannun YA. Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae. J Biol Chem. 2004 Mar 19; 279(12):11537-45. PMID: 14699160.
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    308. Pettus BJ, Bielawska A, Subramanian P, Wijesinghe DS, Maceyka M, Leslie CC, Evans JH, Freiberg J, Roddy P, Hannun YA, Chalfant CE. Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2. J Biol Chem. 2004 Mar 19; 279(12):11320-6. PMID: 14676210.
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    309. Chalfant CE, Szulc Z, Roddy P, Bielawska A, Hannun YA. The structural requirements for ceramide activation of serine-threonine protein phosphatases. J Lipid Res. 2004 Mar; 45(3):496-506. PMID: 14657198.
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    310. Sundararaj KP, Wood RE, Ponnusamy S, Salas AM, Szulc Z, Bielawska A, Obeid LM, Hannun YA, Ogretmen B. Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem. 2004 Feb 13; 279(7):6152-62. PMID: 14630908.
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    311. Becker KP, Hannun YA. cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes. J Biol Chem. 2003 Dec 26; 278(52):52747-54. PMID: 14527960.
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    312. Obeid LM, Hannun YA. Ceramide, stress, and a "LAG" in aging. Sci Aging Knowledge Environ. 2003 Oct 01; 2003(39):PE27. PMID: 14523222.
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    313. Luberto C, Martinez-Mariño B, Taraskiewicz D, Bolaños B, Chitano P, Toffaletti DL, Cox GM, Perfect JR, Hannun YA, Balish E, Del Poeta M. Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. J Clin Invest. 2003 Oct; 112(7):1080-94. PMID: 14523045.
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    314. Pettus BJ, Bielawski J, Porcelli AM, Reames DL, Johnson KR, Morrow J, Chalfant CE, Obeid LM, Hannun YA. The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J. 2003 Aug; 17(11):1411-21. PMID: 12890694.
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    315. Pettus BJ, Bielawska A, Spiegel S, Roddy P, Hannun YA, Chalfant CE. Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem. 2003 Oct 03; 278(40):38206-13. PMID: 12855693.
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    316. Okamoto Y, Vaena de Avalos S, Hannun YA. Functional analysis of ISC1 by site-directed mutagenesis. Biochemistry. 2003 Jul 01; 42(25):7855-62. PMID: 12820895.
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    317. Luberto C, Stonehouse MJ, Collins EA, Marchesini N, El-Bawab S, Vasil AI, Vasil ML, Hannun YA. Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme. J Biol Chem. 2003 Aug 29; 278(35):32733-43. PMID: 12799377.
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    318. Cowart LA, Okamoto Y, Pinto FR, Gandy JL, Almeida JS, Hannun YA. Roles for sphingolipid biosynthesis in mediation of specific programs of the heat stress response determined through gene expression profiling. J Biol Chem. 2003 Aug 08; 278(32):30328-38. PMID: 12740364.
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    319. Schanberg SM, Ingledue VF, Lee JY, Hannun YA, Bartolome JV. PKC alpha mediates maternal touch regulation of growth-related gene expression in infant rats. Neuropsychopharmacology. 2003 Jun; 28(6):1026-30. PMID: 12700701.
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    320. Hyer ML, Sudarshan S, Schwartz DA, Hannun Y, Dong JY, Norris JS. Quantification and characterization of the bystander effect in prostate cancer cells following adenovirus-mediated FasL expression. Cancer Gene Ther. 2003 Apr; 10(4):330-9. PMID: 12679806.
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    321. Kroesen BJ, Jacobs S, Pettus BJ, Sietsma H, Kok JW, Hannun YA, de Leij LF. BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. J Biol Chem. 2003 Apr 25; 278(17):14723-31. PMID: 12578840.
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    322. Marchesini N, Luberto C, Hannun YA. Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem. 2003 Apr 18; 278(16):13775-83. PMID: 12566438.
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    323. Sato M, Markiewicz M, Yamanaka M, Bielawska A, Mao C, Obeid LM, Hannun YA, Trojanowska M. Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators. J Biol Chem. 2003 Mar 14; 278(11):9276-82. PMID: 12515830.
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    324. Pettus BJ, Bielawska A, Kroesen BJ, Moeller PD, Szulc ZM, Hannun YA, Busman M. Observation of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom. 2003; 17(11):1203-11. PMID: 12772277.
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    325. Pettus BJ, Chalfant CE, Hannun YA. Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta. 2002 Dec 30; 1585(2-3):114-25. PMID: 12531544.
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    326. Cowart LA, Szulc Z, Bielawska A, Hannun YA. Structural determinants of sphingolipid recognition by commercially available anti-ceramide antibodies. J Lipid Res. 2002 Dec; 43(12):2042-8. PMID: 12454264.
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    327. Okamoto Y, Obeid LM, Hannun YA. Bcl-xL interrupts oxidative activation of neutral sphingomyelinase. FEBS Lett. 2002 Oct 23; 530(1-3):104-8. PMID: 12387875.
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    328. Okamoto Y, Vaena De Avalos S, Hannun YA. Structural requirements for selective binding of ISC1 to anionic phospholipids. J Biol Chem. 2002 Nov 29; 277(48):46470-7. PMID: 12244059.
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    329. Jenkins GM, Cowart LA, Signorelli P, Pettus BJ, Chalfant CE, Hannun YA. Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins. J Biol Chem. 2002 Nov 08; 277(45):42572-8. PMID: 12200446.
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    330. Luberto C, Kraveka JM, Hannun YA. Ceramide regulation of apoptosis versus differentiation: a walk on a fine line. Lessons from neurobiology. Neurochem Res. 2002 Aug; 27(7-8):609-17. PMID: 12374196.
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    331. Luberto C, Hassler DF, Signorelli P, Okamoto Y, Sawai H, Boros E, Hazen-Martin DJ, Obeid LM, Hannun YA, Smith GK. Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem. 2002 Oct 25; 277(43):41128-39. PMID: 12154098.
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    332. Johnson KR, Becker KP, Facchinetti MM, Hannun YA, Obeid LM. PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem. 2002 Sep 20; 277(38):35257-62. PMID: 12124383.
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    333. Hannun YA, Obeid LM. The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem. 2002 Jul 19; 277(29):25847-50. PMID: 12011103.
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    334. Raisova M, Goltz G, Bektas M, Bielawska A, Riebeling C, Hossini AM, Eberle J, Hannun YA, Orfanos CE, Geilen CC. Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes. FEBS Lett. 2002 Apr 10; 516(1-3):47-52. PMID: 11959101.
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    335. Jones JA, Hannun YA. Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid. J Biol Chem. 2002 May 03; 277(18):15530-8. PMID: 11856740.
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    336. Ogretmen B, Pettus BJ, Rossi MJ, Wood R, Usta J, Szulc Z, Bielawska A, Obeid LM, Hannun YA. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. J Biol Chem. 2002 Apr 12; 277(15):12960-9. PMID: 11815611.
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    337. Chalfant CE, Rathman K, Pinkerman RL, Wood RE, Obeid LM, Ogretmen B, Hannun YA. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem. 2002 Apr 12; 277(15):12587-95. PMID: 11801602.
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    338. Signorelli P, Hannun YA. Analysis and quantitation of ceramide. Methods Enzymol. 2002; 345:275-94. PMID: 11665612.
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    339. Birbes H, El Bawab S, Obeid LM, Hannun YA. Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Adv Enzyme Regul. 2002; 42:113-29. PMID: 12123710.
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    340. El Bawab S, Usta J, Roddy P, Szulc ZM, Bielawska A, Hannun YA. Substrate specificity of rat brain ceramidase. J Lipid Res. 2002 Jan; 43(1):141-8. PMID: 11792733.
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    341. Argraves KM, Obeid LM, Hannun YA. Sphingolipids in vascular biology. Adv Exp Med Biol. 2002; 507:439-44. PMID: 12664623.
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    342. Birbes H, El Bawab S, Hannun YA, Obeid LM. Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J. 2001 Dec; 15(14):2669-79. PMID: 11726543.
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    343. Ogretmen B, Hannun YA. Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance. Drug Resist Updat. 2001 Dec; 4(6):368-77. PMID: 12030784.
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    344. Bielawska A, Perry DK, Hannun YA. Determination of ceramides and diglycerides by the diglyceride kinase assay. Anal Biochem. 2001 Nov 15; 298(2):141-50. PMID: 11757501.
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    345. Signorelli P, Luberto C, Hannun YA. Ceramide inhibition of NF-kappaB activation involves reverse translocation of classical protein kinase C (PKC) isoenzymes: requirement for kinase activity and carboxyl-terminal phosphorylation of PKC for the ceramide response. FASEB J. 2001 Nov; 15(13):2401-14. PMID: 11689465.
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    346. Hayter HL, Pettus BJ, Ito F, Obeid LM, Hannun YA. TNFalpha-induced glutathione depletion lies downstream of cPLA(2) in L929 cells. FEBS Lett. 2001 Oct 26; 507(2):151-6. PMID: 11684089.
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    347. Chalfant CE, Ogretmen B, Galadari S, Kroesen BJ, Pettus BJ, Hannun YA. FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1. J Biol Chem. 2001 Nov 30; 276(48):44848-55. PMID: 11502750.
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    348. Dbaibo GS, El-Assaad W, Krikorian A, Liu B, Diab K, Idriss NZ, El-Sabban M, Driscoll TA, Perry DK, Hannun YA. Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell death. FEBS Lett. 2001 Aug 10; 503(1):7-12. PMID: 11513845.
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    349. Chung N, Mao C, Heitman J, Hannun YA, Obeid LM. Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae. J Biol Chem. 2001 Sep 21; 276(38):35614-21. PMID: 11468289.
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    350. Boujaoude LC, Bradshaw-Wilder C, Mao C, Cohn J, Ogretmen B, Hannun YA, Obeid LM. Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. J Biol Chem. 2001 Sep 21; 276(38):35258-64. PMID: 11443135.
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    351. Ogretmen B, Kraveka JM, Schady D, Usta J, Hannun YA, Obeid LM. Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line. J Biol Chem. 2001 Aug 31; 276(35):32506-14. PMID: 11441001.
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    352. Ogretmen B, Schady D, Usta J, Wood R, Kraveka JM, Luberto C, Birbes H, Hannun YA, Obeid LM. Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells. J Biol Chem. 2001 Jul 06; 276(27):24901-10. PMID: 11335714.
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    353. Hannun YA, Luberto C, Argraves KM. Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry. 2001 Apr 24; 40(16):4893-903. PMID: 11305904.
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    354. El Bawab S, Birbes H, Roddy P, Szulc ZM, Bielawska A, Hannun YA. Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. J Biol Chem. 2001 May 18; 276(20):16758-66. PMID: 11278489.
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    355. Selzner M, Bielawska A, Morse MA, Rüdiger HA, Sindram D, Hannun YA, Clavien PA. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res. 2001 Feb 01; 61(3):1233-40. PMID: 11221856.
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    356. Kroesen BJ, Pettus B, Luberto C, Busman M, Sietsma H, de Leij L, Hannun YA. Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. J Biol Chem. 2001 Apr 27; 276(17):13606-14. PMID: 11278517.
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    357. Luberto C, Toffaletti DL, Wills EA, Tucker SC, Casadevall A, Perfect JR, Hannun YA, Del Poeta M. Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans. Genes Dev. 2001 Jan 15; 15(2):201-12. PMID: 11157776.
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    358. Sawai H, Okamoto Y, Luberto C, Mao C, Bielawska A, Domae N, Hannun YA. Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. J Biol Chem. 2000 Dec 15; 275(50):39793-8. PMID: 11006294.
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    359. Jenkins GM, Hannun YA. Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae. J Biol Chem. 2001 Mar 16; 276(11):8574-81. PMID: 11056159.
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    360. Lee JY, Hannun YA, Obeid LM. Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha. J Biol Chem. 2000 Sep 22; 275(38):29290-8. PMID: 10887171.
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    361. El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA. Molecular cloning and characterization of a human mitochondrial ceramidase. J Biol Chem. 2000 Jul 14; 275(28):21508-13. PMID: 10781606.
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    362. Chung N, Jenkins G, Hannun YA, Heitman J, Obeid LM. Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. J Biol Chem. 2000 Jun 09; 275(23):17229-32. PMID: 10764732.
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    363. Feng X, Becker KP, Stribling SD, Peters KG, Hannun YA. Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation. J Biol Chem. 2000 Jun 02; 275(22):17024-34. PMID: 10828076.
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    364. Bae SS, Perry DK, Oh YS, Choi JH, Galadari SH, Ghayur T, Ryu SH, Hannun YA, Suh PG. Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells. FASEB J. 2000 Jun; 14(9):1083-92. PMID: 10834929.
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    365. Luberto C, Yoo DS, Suidan HS, Bartoli GM, Hannun YA. Differential effects of sphingomyelin hydrolysis and resynthesis on the activation of NF-kappa B in normal and SV40-transformed human fibroblasts. J Biol Chem. 2000 May 12; 275(19):14760-6. PMID: 10799564.
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    366. Perry DK, Carton J, Shah AK, Meredith F, Uhlinger DJ, Hannun YA. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem. 2000 Mar 24; 275(12):9078-84. PMID: 10722759.
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    367. Van Tiel CM, Luberto C, Snoek GT, Hannun YA, Wirtz KW. Rapid replenishment of sphingomyelin in the plasma membrane upon degradation by sphingomyelinase in NIH3T3 cells overexpressing the phosphatidylinositol transfer protein beta. Biochem J. 2000 Mar 01; 346 Pt 2:537-43. PMID: 10677376.
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    368. Hannun YA, Luberto C. Ceramide in the eukaryotic stress response. Trends Cell Biol. 2000 Feb; 10(2):73-80. PMID: 10652518.
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    369. Liu B, Hannun YA. Purification of rat brain membrane neutral sphingomyelinase. Methods Enzymol. 2000; 311:156-64. PMID: 10563320.
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    370. Liu B, Hannun YA. Sphingomyelinase assay using radiolabeled substrate. Methods Enzymol. 2000; 311:164-7. PMID: 10563321.
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    371. Bielawska A, Hannun YA. Preparation of radiolabeled ceramides and phosphosphingolipids. Methods Enzymol. 2000; 311:499-518. PMID: 10563346.
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    372. Bielawska A, Szulc Z, Hannun YA. Synthesis of key precursors of radiolabeled sphingolipids. Methods Enzymol. 2000; 311:518-35. PMID: 10563347.
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    373. Luberto C, Hannun YA. Use of short-chain ceramides. Methods Enzymol. 2000; 312:407-20. PMID: 11070889.
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    374. Perry DK, Bielawska A, Hannun YA. Quantitative determination of ceramide using diglyceride kinase. Methods Enzymol. 2000; 312:22-31. PMID: 11070860.
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    375. Smith ER, Merrill AH, Obeid LM, Hannun YA. Effects of sphingosine and other sphingolipids on protein kinase C. Methods Enzymol. 2000; 312:361-73. PMID: 11070884.
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    376. Chalfant CE, Kishikawa K, Bielawska A, Hannun YA. Analysis of ceramide-activated protein phosphatases. Methods Enzymol. 2000; 312:420-8. PMID: 11070890.
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    377. Sawai H, Domae N, Nagan N, Hannun YA. Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. J Biol Chem. 1999 Dec 31; 274(53):38131-9. PMID: 10608884.
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    378. Juo P, Woo MS, Kuo CJ, Signorelli P, Biemann HP, Hannun YA, Blenis J. FADD is required for multiple signaling events downstream of the receptor Fas. Cell Growth Differ. 1999 Dec; 10(12):797-804. PMID: 10616904.
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    379. Sawai H, Hannun YA. Ceramide and sphingomyelinases in the regulation of stress responses. Chem Phys Lipids. 1999 Nov; 102(1-2):141-7. PMID: 11001568.
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    380. El Bawab S, Bielawska A, Hannun YA. Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain. J Biol Chem. 1999 Sep 24; 274(39):27948-55. PMID: 10488143.
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    381. Kishikawa K, Chalfant CE, Perry DK, Bielawska A, Hannun YA. Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses. J Biol Chem. 1999 Jul 23; 274(30):21335-41. PMID: 10409693.
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    382. Chalfant CE, Kishikawa K, Mumby MC, Kamibayashi C, Bielawska A, Hannun YA. Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. J Biol Chem. 1999 Jul 16; 274(29):20313-7. PMID: 10400653.
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    383. Zhang J, Hannun YA, Obeid LM. A novel assay for apoptotic body formation and membrane release during apoptosis. Cell Death Differ. 1999 Jul; 6(7):596-8. PMID: 10515704.
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    384. Perry DK, Hannun YA. The use of diglyceride kinase for quantifying ceramide. Trends Biochem Sci. 1999 Jun; 24(6):226-7. PMID: 10366848.
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    385. Kolesnick R, Hannun YA. Ceramide and apoptosis. Trends Biochem Sci. 1999 Jun; 24(6):224-5; author reply 227. PMID: 10366847.
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    386. Zhang J, Reedy MC, Hannun YA, Obeid LM. Inhibition of caspases inhibits the release of apoptotic bodies: Bcl-2 inhibits the initiation of formation of apoptotic bodies in chemotherapeutic agent-induced apoptosis. J Cell Biol. 1999 Apr 05; 145(1):99-108. PMID: 10189371.
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    387. Luberto C, Hannun YA. Sphingolipid metabolism in the regulation of bioactive molecules. Lipids. 1999; 34 Suppl:S5-11. PMID: 10419081.
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    388. Liu B, Hassler DF, Smith GK, Weaver K, Hannun YA. Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain. J Biol Chem. 1998 Dec 18; 273(51):34472-9. PMID: 9852115.
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    389. Perry DK, Hannun YA. The role of ceramide in cell signaling. Biochim Biophys Acta. 1998 Dec 08; 1436(1-2):233-43. PMID: 9838138.
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    390. Feng X, Hannun YA. An essential role for autophosphorylation in the dissociation of activated protein kinase C from the plasma membrane. J Biol Chem. 1998 Oct 09; 273(41):26870-4. PMID: 9756933.
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    391. Dbaibo GS, Hannun YA. Signal transduction and the regulation of apoptosis: roles of ceramide. Apoptosis. 1998 Oct; 3(5):317-34. PMID: 14646479.
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    392. Zhang J, Driscoll TA, Hannun YA, Obeid LM. Regulation of membrane release in apoptosis. Biochem J. 1998 Sep 01; 334 ( Pt 2):479-85. PMID: 9716508.
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    393. Galadari S, Kishikawa K, Kamibayashi C, Mumby MC, Hannun YA. Purification and characterization of ceramide-activated protein phosphatases. Biochemistry. 1998 Aug 11; 37(32):11232-8. PMID: 9698369.
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    394. Dbaibo GS, Pushkareva MY, Rachid RA, Alter N, Smyth MJ, Obeid LM, Hannun YA. p53-dependent ceramide response to genotoxic stress. J Clin Invest. 1998 Jul 15; 102(2):329-39. PMID: 9664074.
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    395. Perry SW, Hamilton JA, Tjoelker LW, Dbaibo G, Dzenko KA, Epstein LG, Hannun Y, Whittaker JS, Dewhurst S, Gelbard HA. Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis. J Biol Chem. 1998 Jul 10; 273(28):17660-4. PMID: 9651362.
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    396. Luberto C, Hannun YA. Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? J Biol Chem. 1998 Jun 05; 273(23):14550-9. PMID: 9603970.
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    397. Laethem RM, Hannun YA, Jayadev S, Sexton CJ, Strum JC, Sundseth R, Smith GK. Increases in neutral, Mg2+-dependent and acidic, Mg2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase 3-like activity in Molt-4 cells in response to thymidylate synthase inhibition by GW1843. Blood. 1998 Jun 01; 91(11):4350-60. PMID: 9596684.
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    398. Liu B, Andrieu-Abadie N, Levade T, Zhang P, Obeid LM, Hannun YA. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J Biol Chem. 1998 May 01; 273(18):11313-20. PMID: 9556624.
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    399. Feng X, Zhang J, Barak LS, Meyer T, Caron MG, Hannun YA. Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization. J Biol Chem. 1998 Apr 24; 273(17):10755-62. PMID: 9553141.
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    400. Flores I, Martinez-A C, Hannun YA, Mérida I. Dual role of ceramide in the control of apoptosis following IL-2 withdrawal. J Immunol. 1998 Apr 01; 160(7):3528-33. PMID: 9531315.
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    401. Rizzieri KE, Hannun YA. Sphingolipid metabolism, apoptosis and resistance to cytotoxic agents: can we interfere? Drug Resist Updat. 1998; 1(6):359-76. PMID: 17092818.
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    402. Jenkins GM, Richards A, Wahl T, Mao C, Obeid L, Hannun Y. Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae. J Biol Chem. 1997 Dec 19; 272(51):32566-72. PMID: 9405471.
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    403. Mao C, Wadleigh M, Jenkins GM, Hannun YA, Obeid LM. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J Biol Chem. 1997 Nov 07; 272(45):28690-4. PMID: 9353337.
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    404. Hannun YA, Obeid LM. Ceramide and the eukaryotic stress response. Biochem Soc Trans. 1997 Nov; 25(4):1171-5. PMID: 9449970.
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    405. Bielawska AE, Shapiro JP, Jiang L, Melkonyan HS, Piot C, Wolfe CL, Tomei LD, Hannun YA, Umansky SR. Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. Am J Pathol. 1997 Nov; 151(5):1257-63. PMID: 9358751.
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    406. Saba JD, Nara F, Bielawska A, Garrett S, Hannun YA. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem. 1997 Oct 17; 272(42):26087-90. PMID: 9334171.
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    407. Lee TG, Park JB, Lee SD, Hong S, Kim JH, Kim Y, Yi KS, Bae S, Hannun YA, Obeid LM, Suh PG, Ryu SH. Phorbol myristate acetate-dependent association of protein kinase C alpha with phospholipase D1 in intact cells. Biochim Biophys Acta. 1997 Aug 16; 1347(2-3):199-204. PMID: 9295164.
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    408. Perry DK, Smyth MJ, Stennicke HR, Salvesen GS, Duriez P, Poirier GG, Hannun YA. Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem. 1997 Jul 25; 272(30):18530-3. PMID: 9228015.
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    409. Wieder T, Geilen CC, Kolter T, Sadeghlar F, Sandhoff K, Brossmer R, Ihrig P, Perry D, Orfanos CE, Hannun YA. Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues. FEBS Lett. 1997 Jul 14; 411(2-3):260-4. PMID: 9271217.
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    410. Jayadev S, Hayter HL, Andrieu N, Gamard CJ, Liu B, Balu R, Hayakawa M, Ito F, Hannun YA. Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells. J Biol Chem. 1997 Jul 04; 272(27):17196-203. PMID: 9202042.
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    411. Liu B, Hannun YA. Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J Biol Chem. 1997 Jun 27; 272(26):16281-7. PMID: 9195931.
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    412. Lai TS, Bielawska A, Peoples KA, Hannun YA, Greenberg CS. Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase. J Biol Chem. 1997 Jun 27; 272(26):16295-300. PMID: 9195933.
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    413. Gamard CJ, Dbaibo GS, Liu B, Obeid LM, Hannun YA. Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB. J Biol Chem. 1997 Jun 27; 272(26):16474-81. PMID: 9195956.
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    414. Wang Y, Roman R, Schlenker T, Hannun YA, Raymond J, Fitz JG. Cytosolic Ca2+ and protein kinase Calpha couple cellular metabolism to membrane K+ permeability in a human biliary cell line. J Clin Invest. 1997 Jun 15; 99(12):2890-7. PMID: 9185512.
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    415. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG, Brenner DA. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology. 1997 May; 25(5):1128-35. PMID: 9141429.
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    416. Zhang P, Liu B, Jenkins GM, Hannun YA, Obeid LM. Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. J Biol Chem. 1997 Apr 11; 272(15):9609-12. PMID: 9092485.
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    417. Dbaibo GS, Perry DK, Gamard CJ, Platt R, Poirier GG, Obeid LM, Hannun YA. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J Exp Med. 1997 Feb 03; 185(3):481-90. PMID: 9053448.
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    418. Puranam K, Qian WH, Nikbakht K, Venable M, Obeid L, Hannun Y, Boustany RM. Upregulation of Bcl-2 and elevation of ceramide in Batten disease. Neuropediatrics. 1997 Feb; 28(1):37-41. PMID: 9151319.
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    419. Hannun YA, Obeid LM. Mechanisms of ceramide-mediated apoptosis. Adv Exp Med Biol. 1997; 407:145-9. PMID: 9321945.
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    420. Hannun YA. Sphingolipid second messengers: tumor suppressor lipids. Adv Exp Med Biol. 1997; 400A:305-12. PMID: 9547572.
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    421. Liu B, Maher RJ, De Jonckheere JP, Popat RU, Stojakovic S, Hannun YA, Porter AT, Honn KV. 12(S)-HETE increases the motility of prostate tumor cells through selective activation of PKC alpha. Adv Exp Med Biol. 1997; 400B:707-18. PMID: 9547622.
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    422. Smyth MJ, Obeid LM, Hannun YA. Ceramide: a novel lipid mediator of apoptosis. Adv Pharmacol. 1997; 41:133-54. PMID: 9204144.
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    423. Perry DK, Smyth MJ, Wang HG, Reed JC, Duriez P, Poirier GG, Obeid LM, Hannun YA. Bcl-2 acts upstream of the PARP protease and prevents its activation. Cell Death Differ. 1997 Jan; 4(1):29-33. PMID: 16465207.
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    424. Hannun YA. Functions of ceramide in coordinating cellular responses to stress. Science. 1996 Dec 13; 274(5294):1855-9. PMID: 8943189.
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    425. Jideama NM, Noland TA, Raynor RL, Blobe GC, Fabbro D, Kazanietz MG, Blumberg PM, Hannun YA, Kuo JF. Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem. 1996 Sep 20; 271(38):23277-83. PMID: 8798526.
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    426. Jayadev S, Hannun YA. Ceramide: role in growth inhibitory cascades. J Lipid Mediat Cell Signal. 1996 Sep; 14(1-3):295-301. PMID: 8906575.
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    427. Wang Y, Sostman A, Roman R, Stribling S, Vigna S, Hannun Y, Raymond J, Fitz JG. Metabolic stress opens K+ channels in hepatoma cells through a Ca2+- and protein kinase calpha-dependent mechanism. J Biol Chem. 1996 Jul 26; 271(30):18107-13. PMID: 8663472.
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    428. Kawamura A, Berova N, Dirsch V, Mangoni A, Nakanishi K, Schwartz G, Bielawska A, Hannun Y, Kitagawa I. Picomole scale stereochemical analysis of sphingosines and dihydrosphingosines. Bioorg Med Chem. 1996 Jul; 4(7):1035-43. PMID: 8831974.
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    429. Perry DK, Obeid LM, Hannun YA. Ceramide and the regulation of apoptosis and the stress response. Trends Cardiovasc Med. 1996 Jul; 6(5):158-62. PMID: 21232290.
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    430. Blobe GC, Stribling DS, Fabbro D, Stabel S, Hannun YA. Protein kinase C beta II specifically binds to and is activated by F-actin. J Biol Chem. 1996 Jun 28; 271(26):15823-30. PMID: 8663149.
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    431. Linardic CM, Jayadev S, Hannun YA. Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking. Cell Growth Differ. 1996 Jun; 7(6):765-74. PMID: 8780890.
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    432. Lee JY, Hannun YA, Obeid LM. Ceramide inactivates cellular protein kinase Calpha. J Biol Chem. 1996 May 31; 271(22):13169-74. PMID: 8662781.
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    433. Zhang J, Alter N, Reed JC, Borner C, Obeid LM, Hannun YA. Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5325-8. PMID: 8643573.
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    434. Bielawska A, Greenberg MS, Perry D, Jayadev S, Shayman JA, McKay C, Hannun YA. (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase. J Biol Chem. 1996 May 24; 271(21):12646-54. PMID: 8647877.
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    435. Smyth MJ, Perry DK, Zhang J, Poirier GG, Hannun YA, Obeid LM. prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem J. 1996 May 15; 316 ( Pt 1):25-8. PMID: 8645213.
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    436. Hayakawa M, Jayadev S, Tsujimoto M, Hannun YA, Ito F. Role of ceramide in stimulation of the transcription of cytosolic phospholipase A2 and cyclooxygenase 2. Biochem Biophys Res Commun. 1996 Mar 27; 220(3):681-6. PMID: 8607825.
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    437. Saba JD, Obeid LM, Hannun YA. Ceramide: an intracellular mediator of apoptosis and growth suppression. Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29; 351(1336):233-40; discussion 240-1. PMID: 8650271.
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    438. Blobe GC, Stribling S, Obeid LM, Hannun YA. Protein kinase C isoenzymes: regulation and function. Cancer Surv. 1996; 27:213-48. PMID: 8909803.
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    439. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA, Brenner DA. Ceramide activates the stress-activated protein kinases. J Biol Chem. 1995 Sep 29; 270(39):22689-92. PMID: 7559390.
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    440. Liu B, Khan WA, Hannun YA, Timar J, Taylor JD, Lundy S, Butovich I, Honn KV. 12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. Proc Natl Acad Sci U S A. 1995 Sep 26; 92(20):9323-7. PMID: 7568126.
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    441. Dobrowsky RT, Jenkins GM, Hannun YA. Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors. J Biol Chem. 1995 Sep 22; 270(38):22135-42. PMID: 7673191.
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    442. Dbaibo GS, Wolff RA, Obeid LM, Hannun YA. Activation of a retinoblastoma-protein-dependent pathway by sphingosine. Biochem J. 1995 Sep 01; 310 ( Pt 2):453-9. PMID: 7654183.
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    443. Tepper CG, Jayadev S, Liu B, Bielawska A, Wolff R, Yonehara S, Hannun YA, Seldin MF. Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8443-7. PMID: 7545303.
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    444. Laulederkind SJ, Bielawska A, Raghow R, Hannun YA, Ballou LR. Ceramide induces interleukin 6 gene expression in human fibroblasts. J Exp Med. 1995 Aug 01; 182(2):599-604. PMID: 7629516.
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    445. Obeid LM, Hannun YA. Ceramide: a stress signal and mediator of growth suppression and apoptosis. J Cell Biochem. 1995 Jun; 58(2):191-8. PMID: 7673327.
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    446. Pushkareva M, Obeid LM, Hannun YA. Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunol Today. 1995 Jun; 16(6):294-7. PMID: 7662099.
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    447. Khan WA, Blobe GC, Hannun YA. Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C. Cell Signal. 1995 Mar; 7(3):171-84. PMID: 7662506.
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    448. Dbaibo GS, Pushkareva MY, Jayadev S, Schwarz JK, Horowitz JM, Obeid LM, Hannun YA. Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1347-51. PMID: 7877980.
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    449. Pushkareva M, Chao R, Bielawska A, Merrill AH, Crane HM, Lagu B, Liotta D, Hannun YA. Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine. Biochemistry. 1995 Feb 14; 34(6):1885-92. PMID: 7849048.
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    450. Jayadev S, Liu B, Bielawska AE, Lee JY, Nazaire F, Obeid LM, Hannun YA. Role for ceramide in cell cycle arrest. J Biol Chem. 1995 Feb 03; 270(5):2047-52. PMID: 7836432.
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    451. Blobe GC, Khan WA, Hannun YA. Protein kinase C: cellular target of the second messenger arachidonic acid? Prostaglandins Leukot Essent Fatty Acids. 1995 Feb-Mar; 52(2-3):129-35. PMID: 7784448.
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    452. Hannun YA, Obeid LM. Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci. 1995 Feb; 20(2):73-7. PMID: 7701566.
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    453. Blobe GC, Obeid LM, Hannun YA. Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Rev. 1994 Dec; 13(3-4):411-31. PMID: 7712599.
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    454. Alcantara O, Obeid L, Hannun Y, Ponka P, Boldt DH. Regulation of protein kinase C (PKC) expression by iron: effect of different iron compounds on PKC-beta and PKC-alpha gene expression and role of the 5'-flanking region of the PKC-beta gene in the response to ferric transferrin. Blood. 1994 Nov 15; 84(10):3510-7. PMID: 7949105.
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    455. Linardic CM, Hannun YA. Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle. J Biol Chem. 1994 Sep 23; 269(38):23530-7. PMID: 8089120.
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    456. Dobrowsky RT, Werner MH, Castellino AM, Chao MV, Hannun YA. Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science. 1994 Sep 09; 265(5178):1596-9. PMID: 8079174.
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    457. Liu B, Maher RJ, Hannun YA, Porter AT, Honn KV. 12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha. J Natl Cancer Inst. 1994 Aug 03; 86(15):1145-51. PMID: 7518003.
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    458. Wolff RA, Dobrowsky RT, Bielawska A, Obeid LM, Hannun YA. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem. 1994 Jul 29; 269(30):19605-9. PMID: 8034729.
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    459. Khan WA, Blobe GC, Richards AL, Hannun YA. Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets. J Biol Chem. 1994 Apr 01; 269(13):9729-35. PMID: 8144564.
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    460. Gamard CJ, Blobe GC, Hannun YA, Obeid LM. Specific role for protein kinase C beta in cell differentiation. Cell Growth Differ. 1994 Apr; 5(4):405-9. PMID: 8043514.
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    461. Hannun YA. Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine. Biochim Biophys Acta. 1994 Mar 10; 1221(1):54-60. PMID: 8130276.
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    462. Jayadev S, Linardic CM, Hannun YA. Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha. J Biol Chem. 1994 Feb 25; 269(8):5757-63. PMID: 8119915.
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    463. Okazaki T, Bielawska A, Domae N, Bell RM, Hannun YA. Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem. 1994 Feb 11; 269(6):4070-7. PMID: 8307965.
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    464. Hannun YA. The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem. 1994 Feb 04; 269(5):3125-8. PMID: 8106344.
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    465. Ghalayini AJ, Koutz CA, Wetsel WC, Hannun YA, Anderson RE. Immunolocalization of PKC zeta in rat photoreceptor inner segments. Curr Eye Res. 1994 Feb; 13(2):145-50. PMID: 8194361.
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    466. Hannun YA, Linardic CM. Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. Biochim Biophys Acta. 1993 Dec 21; 1154(3-4):223-36. PMID: 8280742.
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    467. Bielawska A, Crane HM, Liotta D, Obeid LM, Hannun YA. Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem. 1993 Dec 15; 268(35):26226-32. PMID: 8253743.
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    468. Bielawska A, Menaldiv D, Liotta D, Hannun YA. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids. Biochem J. 1993 Sep 15; 294 ( Pt 3):699-703. PMID: 8379926.
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    469. Dbaibo GS, Obeid LM, Hannun YA. Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B. J Biol Chem. 1993 Aug 25; 268(24):17762-6. PMID: 8349660.
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    470. Dobrowsky RT, Kamibayashi C, Mumby MC, Hannun YA. Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem. 1993 Jul 25; 268(21):15523-30. PMID: 8393446.
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    471. Middleton JP, Khan WA, Collinsworth G, Hannun YA, Medford RM. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25; 268(21):15958-64. PMID: 8393456.
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    472. Blobe GC, Khan WA, Halpern AE, Obeid LM, Hannun YA. Selective regulation of expression of protein kinase C beta isoenzymes occurs via alternative splicing. J Biol Chem. 1993 May 15; 268(14):10627-35. PMID: 7683684.
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    473. Fishbein JD, Dobrowsky RT, Bielawska A, Garrett S, Hannun YA. Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. J Biol Chem. 1993 May 05; 268(13):9255-61. PMID: 8387486.
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    474. Obeid LM, Linardic CM, Karolak LA, Hannun YA. Programmed cell death induced by ceramide. Science. 1993 Mar 19; 259(5102):1769-71. PMID: 8456305.
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    475. Khan WA, Blobe G, Halpern A, Taylor W, Wetsel WC, Burns D, Loomis C, Hannun YA. Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets. J Biol Chem. 1993 Mar 05; 268(7):5063-8. PMID: 8444883.
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    476. Tuominen RK, Werner MH, Ye H, McMillian MK, Hudson PM, Hannun YA, Hong JS. Biphasic generation of diacylglycerol by angiotensin and phorbol ester in bovine adrenal chromaffin cells. Biochem Biophys Res Commun. 1993 Jan 15; 190(1):181-5. PMID: 8380691.
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    477. Blobe GC, Sachs CW, Khan WA, Fabbro D, Stabel S, Wetsel WC, Obeid LM, Fine RL, Hannun YA. Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. J Biol Chem. 1993 Jan 05; 268(1):658-64. PMID: 8093247.
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    478. Karolak L, Chandra A, Khan W, Marks B, Petros WP, Peters WP, Greenberg CS, Hannun YA. High-dose chemotherapy-induced platelet defect: inhibition of platelet signal transduction pathways. Mol Pharmacol. 1993 Jan; 43(1):37-44. PMID: 8423767.
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    479. Merrill AH, Hannun YA, Bell RM. Introduction: sphingolipids and their metabolites in cell regulation. Adv Lipid Res. 1993; 25:1-24. PMID: 8368146.
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    480. Hannun YA, Bell RM. The sphingomyelin cycle: a prototypic sphingolipid signaling pathway. Adv Lipid Res. 1993; 25:27-41. PMID: 8368151.
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    481. Hannun YA, Obeid LM, Wolff RA. The novel second messenger ceramide: identification, mechanism of action, and cellular activity. Adv Lipid Res. 1993; 25:43-64. PMID: 8396313.
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    482. Dobrowsky RT, Hannun YA. Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A. Adv Lipid Res. 1993; 25:91-104. PMID: 8396314.
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    483. Setty BN, Werner MH, Hannun YA, Stuart MJ. 15-Hydroxyeicosatetraenoic acid-mediated potentiation of thrombin-induced platelet functions occurs via enhanced production of phosphoinositide-derived second messengers--sn-1,2-diacylglycerol and inositol-1,4,5-trisphosphate. Blood. 1992 Dec 01; 80(11):2765-73. PMID: 1333301.
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    484. Chao R, Khan W, Hannun YA. Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. J Biol Chem. 1992 Nov 25; 267(33):23459-62. PMID: 1385423.
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    485. Obeid LM, Blobe GC, Karolak LA, Hannun YA. Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. J Biol Chem. 1992 Oct 15; 267(29):20804-10. PMID: 1400396.
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    486. Bielawska A, Linardic CM, Hannun YA. Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs. J Biol Chem. 1992 Sep 15; 267(26):18493-7. PMID: 1526986.
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    487. Bielawska A, Linardic CM, Hannun YA. Modulation of cell growth and differentiation by ceramide. FEBS Lett. 1992 Jul 28; 307(2):211-4. PMID: 1644175.
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    488. Linardic CM, Jayadev S, Hannun YA. Brefeldin A promotes hydrolysis of sphingomyelin. J Biol Chem. 1992 Jul 25; 267(21):14909-11. PMID: 1634530.
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    489. Khan WA, Alessenko AV, Sahyoun N, Hannun YA. Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action. J Biol Chem. 1992 Jul 25; 267(21):15246-51. PMID: 1634554.
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    490. Wetsel WC, Khan WA, Merchenthaler I, Rivera H, Halpern AE, Phung HM, Negro-Vilar A, Hannun YA. Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J Cell Biol. 1992 Apr; 117(1):121-33. PMID: 1556149.
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    491. Werner MH, Bielawska AE, Hannun YA. Multiphasic generation of diacylglycerol in thrombin-activated human platelets. Biochem J. 1992 Mar 15; 282 ( Pt 3):815-20. PMID: 1554365.
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    492. Dobrowsky RT, Hannun YA. Ceramide stimulates a cytosolic protein phosphatase. J Biol Chem. 1992 Mar 15; 267(8):5048-51. PMID: 1312082.
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    493. Khan WA, Blobe GC, Hannun YA. Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate. J Biol Chem. 1992 Feb 25; 267(6):3605-12. PMID: 1740412.
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    494. Alessenko A, Khan WA, Wetsel WC, Hannun YA. Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration. Biochem Biophys Res Commun. 1992 Feb 14; 182(3):1333-9. PMID: 1540177.
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    495. Werner MH, Bielawska AE, Hannun YA. Quantitative analysis of diacylglycerol second messengers in human platelets: correlation with aggregation and secretion. Mol Pharmacol. 1992 Feb; 41(2):382-6. PMID: 1538714.
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    496. Bell R, Burns D, Okazaki T, Hannun Y. Network of signal transduction pathways involving lipids: protein kinase C-dependent and -independent pathways. Adv Exp Med Biol. 1992; 318:275-84. PMID: 1636498.
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    497. McDonald OB, Hannun YA, Reynolds CH, Sahyoun N. Activation of casein kinase II by sphingosine. J Biol Chem. 1991 Nov 15; 266(32):21773-6. PMID: 1939200.
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    498. Khan W, el Touny S, Hannun YA. Arachidonic and cis-unsaturated fatty acids induce selective platelet substrate phosphorylation through activation of cytosolic protein kinase C. FEBS Lett. 1991 Nov 04; 292(1-2):98-102. PMID: 1959637.
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    499. Khan WA, Mascarella SW, Lewin AH, Wyrick CD, Carroll FI, Hannun YA. Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets. Biochem J. 1991 Sep 01; 278 ( Pt 2):387-92. PMID: 1898331.
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    500. Werner MH, Hannun YA. Delayed accumulation of diacylglycerol in platelets as a mechanism for regulation of onset of aggregation and secretion. Blood. 1991 Jul 15; 78(2):435-44. PMID: 2070079.
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    501. Dennis EA, Rhee SG, Billah MM, Hannun YA. Role of phospholipase in generating lipid second messengers in signal transduction. FASEB J. 1991 Apr; 5(7):2068-77. PMID: 1901288.
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    502. Werner MH, Senzel L, Bielawska A, Khan W, Hannun YA. Diacylglycerol overcomes aspirin inhibition of platelets: evidence for a necessary role for diacylglycerol accumulation in platelet activation. Mol Pharmacol. 1991 Apr; 39(4):547-56. PMID: 2017154.
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    503. Kim MY, Linardic C, Obeid L, Hannun Y. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. J Biol Chem. 1991 Jan 05; 266(1):484-9. PMID: 1845977.
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    504. Hannun YA, Merrill AH, Bell RM. Use of sphingosine as inhibitor of protein kinase C. Methods Enzymol. 1991; 201:316-28. PMID: 1943771.
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    505. Khan WA, Dobrowsky R, el Touny S, Hannun YA. Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. Biochem Biophys Res Commun. 1990 Oct 30; 172(2):683-91. PMID: 2241961.
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    506. el Touny S, Khan W, Hannun Y. Regulation of platelet protein kinase C by oleic acid. Kinetic analysis of allosteric regulation and effects on autophosphorylation, phorbol ester binding, and susceptibility to inhibition. J Biol Chem. 1990 Sep 25; 265(27):16437-43. PMID: 2118907.
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    507. Okazaki T, Bielawska A, Bell RM, Hannun YA. Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem. 1990 Sep 15; 265(26):15823-31. PMID: 2394750.
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    508. Hannun YA, Bell RM. Rat brain protein kinase C. Kinetic analysis of substrate dependence, allosteric regulation, and autophosphorylation. J Biol Chem. 1990 Feb 15; 265(5):2962-72. PMID: 2303435.
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    509. Obeid LM, Okazaki T, Karolak LA, Hannun YA. Transcriptional regulation of protein kinase C by 1,25-dihydroxyvitamin D3 in HL-60 cells. J Biol Chem. 1990 Feb 05; 265(4):2370-4. PMID: 2298754.
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    510. Hannun YA, Bell RM. Regulation of protein kinase C by sphingosine and lysosphingolipids. Clin Chim Acta. 1989 Dec 15; 185(3):333-45. PMID: 2695275.
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    511. Sane DC, Bielawska A, Greenberg CS, Hannun YA. Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets. Biochem Biophys Res Commun. 1989 Dec 15; 165(2):708-14. PMID: 2557018.
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    512. Okazaki T, Bell RM, Hannun YA. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J Biol Chem. 1989 Nov 15; 264(32):19076-80. PMID: 2808413.
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    513. Conkling PR, Patton KL, Hannun YA, Greenberg CS, Weinberg JB. Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding. J Biol Chem. 1989 Nov 05; 264(31):18440-4. PMID: 2808383.
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    514. Merrill AH, Nimkar S, Menaldino D, Hannun YA, Loomis C, Bell RM, Tyagi SR, Lambeth JD, Stevens VL, Hunter R, et al. Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry. 1989 Apr 18; 28(8):3138-45. PMID: 2742830.
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    515. Hannun YA, Bell RM. Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science. 1989 Jan 27; 243(4890):500-7. PMID: 2643164.
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    516. Faucher M, Gironès N, Hannun YA, Bell RM, Davis RJ. Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells. J Biol Chem. 1988 Apr 15; 263(11):5319-27. PMID: 3162730.
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    517. Hannun YA, Bell RM. Aminoacridines, potent inhibitors of protein kinase C. J Biol Chem. 1988 Apr 15; 263(11):5124-31. PMID: 3258596.
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    518. Bell RM, Loomis CR, Hannun YA. Protein kinase C regulation by sphingosine/lysosphingolipids. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:103-10. PMID: 3076075.
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    519. Hannun YA, Greenberg CS, Bell RM. Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways. J Biol Chem. 1987 Oct 05; 262(28):13620-6. PMID: 3115982.
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    520. Hannun YA, Bell RM. Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. Science. 1987 Feb 06; 235(4789):670-4. PMID: 3101176.
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    521. Hannun YA, Bell RM. Mixed micellar assay for phorbol ester binding. Methods Enzymol. 1987; 141:287-93. PMID: 3298964.
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    522. Hannun YA, Bell RM. Mechanism of activation of protein kinase C: role of diacylglycerol and calcium second messengers. Soc Gen Physiol Ser. 1987; 42:229-40. PMID: 3333191.
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    523. Hannun YA, Loomis CR, Merrill AH, Bell RM. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem. 1986 Sep 25; 261(27):12604-9. PMID: 3462188.
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    524. Merrill AH, Sereni AM, Stevens VL, Hannun YA, Bell RM, Kinkade JM. Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. J Biol Chem. 1986 Sep 25; 261(27):12610-5. PMID: 3462189.
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    525. Hannun YA, Bell RM. Phorbol ester binding and activation of protein kinase C on triton X-100 mixed micelles containing phosphatidylserine. J Biol Chem. 1986 Jul 15; 261(20):9341-7. PMID: 3459728.
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    526. Hannun YA, Loomis CR, Bell RM. Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies. J Biol Chem. 1986 Jun 05; 261(16):7184-90. PMID: 3711083.
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    527. Ganong BR, Loomis CR, Hannun YA, Bell RM. Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols. Proc Natl Acad Sci U S A. 1986 Mar; 83(5):1184-8. PMID: 3456578.
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    528. Bell RM, Hannun Y, Loomis C. Mixed micelle assay of protein kinase C. Methods Enzymol. 1986; 124:353-9. PMID: 3520216.
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    529. Bell RM, Hannun YA, Loomis CR. Mechanism of regulation of protein kinase C by lipid second messengers. Symp Fundam Cancer Res. 1986; 39:145-56. PMID: 3321305.
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    530. Hannun YA, Loomis CR, Bell RM. Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine. J Biol Chem. 1985 Aug 25; 260(18):10039-43. PMID: 3160705.
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