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Last Name
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Wing-Kin Syn

Title
InstitutionMedical University of South Carolina
DepartmentGastroenterology
AddressP.O. Box MSC 702
402
Thurmond Gazes - 30 Courtenay Drive
Phone843-792-3267
Fax843-876-5129
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    Collapse Biography 
    Collapse education and training
    MD
    PhD
    FACP
    FEBGH
    FRCP Edinburgh
    FRCP London

    Collapse Overview 
    Collapse keywords
    Basic Science, Clinical Science / Clinical Trials (Ralph H Johnson Veteran Affairs Medical Center), Fatty Liver Disease, Liver Fibrosis, Metabolism, Models of Disease, Veterans

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shetty A, Syn WK. Current treatment options for nonalcoholic fatty liver disease. Curr Opin Gastroenterol. 2019 Feb 21. PMID: 30844893.
      View in: PubMed
    2. Shetty A, Syn WK. Health and Economic Burden of Nonalcoholic Fatty Liver Disease in the United States and Its Impact on Veterans. Fed Pract. 2019 Jan; 36(1):14-19. PMID: 30766413.
      View in: PubMed
    3. Dismuke-Greer CE, Syn WK. Coming Complications of Nonalcoholic Fatty Liver Disease: Time to GNASH Your Teeth. Dig Dis Sci. 2018 Dec 17. PMID: 30560337.
      View in: PubMed
    4. Hou W, Syn WK. Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis. Front Cell Dev Biol. 2018; 6:150. PMID: 30483502.
      View in: PubMed
    5. Nuñez-Garcia M, Gomez-Santos B, Saenz de Urturi D, Mestre D, Gonzalez-Romero F, Buque X, Gutiérrez-de Juan V, Martinez-Chantar ML, Syn WK, Fresnedo O, Aspichueta P. Atorvastatin provides a new lipidome improving early regeneration after partial hepatectomy in osteopontin deficient mice. Sci Rep. 2018 Oct 02; 8(1):14626. PMID: 30279550.
      View in: PubMed
    6. Glass O, Henao R, Patel K, Guy CD, Gruss HJ, Syn WK, Moylan CA, Streilein R, Hall R, Mae Diehl A, Abdelmalek MF. Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. Hepatol Commun. 2018 Nov; 2(11):1344-1355. PMID: 30411081.
      View in: PubMed
    7. Shetty A, Hsu JW, Manka PP, Syn WK. Role of the Circadian Clock in the Metabolic Syndrome and Nonalcoholic Fatty Liver Disease. Dig Dis Sci. 2018 Aug 18. PMID: 30121811.
      View in: PubMed
    8. Hou W, Trieu C, Du Y, Wang C, Syn WK. Profile of drug resistance mutations in nucleos(t)ide analogue-experienced chronic hepatitis B patients in Tianjin, China. Int J Antimicrob Agents. 2018 Aug 03. PMID: 30081141.
      View in: PubMed
    9. Naggie S, Swiderska-Syn M, Choi S, Lusk S, Lan A, Ferrari G, Syn WK, Guy CD, Diehl AM. Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection. Open Forum Infect Dis. 2018 Jul; 5(7):ofy138. PMID: 29992177.
      View in: PubMed
    10. Manka P, Coombes JD, Boosman R, Gauthier K, Papa S, Syn WK. Thyroid hormone in the regulation of hepatocellular carcinoma and its microenvironment. Cancer Lett. 2018 Apr 10; 419:175-186. PMID: 29414304.
      View in: PubMed
    11. Armstrong MJ, Haydon G, Syn WK. Beyond the liver in patients with non-alcoholic fatty liver disease (NAFLD)-cause for concern? Hepatobiliary Surg Nutr. 2018 Apr; 7(2):138-142. PMID: 29744346.
      View in: PubMed
    12. Alazawi W, Bernabe E, Tai D, Janicki T, Kemos P, Samsuddin S, Syn WK, Gillam D, Turner W. Periodontitis is associated with significant hepatic fibrosis in patients with non-alcoholic fatty liver disease. PLoS One. 2017; 12(12):e0185902. PMID: 29220367.
      View in: PubMed
    13. De Silva S, Li W, Kemos P, Brindley JH, Mecci J, Samsuddin S, Chin-Aleong J, Feakins RM, Foster GR, Syn WK, Alazawi W. Non-invasive markers of liver fibrosis in fatty liver disease are unreliable in people of South Asian descent. Frontline Gastroenterol. 2018 Apr; 9(2):115-121. PMID: 29588839.
      View in: PubMed
    14. Mehta KJ, Coombes JD, Briones-Orta M, Manka PP, Williams R, Patel VB, Syn WK. Iron Enhances Hepatic Fibrogenesis and Activates Transforming Growth Factor-ß Signaling in Murine Hepatic Stellate Cells. Am J Med Sci. 2018 02; 355(2):183-190. PMID: 29406047.
      View in: PubMed
    15. Briones-Orta MA, Avendaño-Vázquez SE, Ivette Aparicio-Bautista D, Coombes JD, Weber GF, Syn WK. Prediction of transcription factor bindings sites affected by SNPs located at the osteopontin promoter. Data Brief. 2017 Oct; 14:538-542. PMID: 28856185.
      View in: PubMed
    16. Nuñez-Garcia M, Gomez-Santos B, Buqué X, García-Rodriguez JL, Romero MR, Marin JJG, Arteta B, García-Monzón C, Castaño L, Syn WK, Fresnedo O, Aspichueta P. Osteopontin regulates the cross-talk between phosphatidylcholine and cholesterol metabolism in mouse liver. J Lipid Res. 2017 Sep; 58(9):1903-1915. PMID: 28754826.
      View in: PubMed
    17. Shetty A, Cho W, Alazawi W, Syn WK. Methotrexate Hepatotoxicity and the Impact of Nonalcoholic Fatty Liver Disease. Am J Med Sci. 2017 08; 354(2):172-181. PMID: 28864376.
      View in: PubMed
    18. Hussain SA, Palmer DH, Syn WK, Sacco JJ, Greensmith RM, Elmetwali T, Aachi V, Lloyd BH, Jithesh PV, Arrand J, Barton D, Ansari J, Sibson DR, James ND. Gene expression profiling in bladder cancer identifies potential therapeutic targets. Int J Oncol. 2017 Apr; 50(4):1147-1159. PMID: 28259975.
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    19. Briones-Orta MA, Avendaño-Vázquez SE, Aparicio-Bautista DI, Coombes JD, Weber GF, Syn WK. Osteopontin splice variants and polymorphisms in cancer progression and prognosis. Biochim Biophys Acta. 2017 08; 1868(1):93-108.A. PMID: 28254527.
      View in: PubMed
    20. de Oliveira FL, Carneiro K, Brito JM, Cabanel M, Pereira JX, Paiva LA, Syn W, Henderson NC, El-Cheikh MC. Galectin-3, histone deacetylases, and Hedgehog signaling: Possible convergent targets in schistosomiasis-induced liver fibrosis. PLoS Negl Trop Dis. 2017 Feb; 11(2):e0005137. PMID: 28231240.
      View in: PubMed
    21. Arffa ML, Zapf MA, Kothari AN, Chang V, Gupta GN, Ding X, Al-Gayyar MM, Syn W, Elsherbiny NM, Kuo PC, Mi Z. Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis. PLoS One. 2016; 11(12):e0167435. PMID: 27935974.
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    22. Verhulst S, Best J, Syn WK, Reynaert H, Hellemans KH, Canbay A, Dolle L, van Grunsven LA. Infliximab and Dexamethasone Attenuate the Ductular Reaction in Mice. Sci Rep. 2016 Nov 08; 6:36586. PMID: 27824131.
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    23. Pereira TA, Syn WK, Amâncio FF, Cunha PH, Caporali JF, Trindade GV, Santos ET, Souza MM, Andrade ZA, Witek RP, Secor WE, Pereira FE, Lambertucci JR, Diehl AM. Osteopontin Is Upregulated in Human and Murine Acute Schistosomiasis Mansoni. PLoS Negl Trop Dis. 2016 Oct; 10(10):e0005057. PMID: 27755536.
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    24. Pereira TA, Syn WK, Pereira FE, Lambertucci JR, Secor WE, Diehl AM. Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni. Int J Parasitol. 2016 Dec; 46(13-14):829-832. PMID: 27729270.
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    25. Best J, Verhulst S, Syn WK, Lagaisse K, van Hul N, Heindryckx F, Sowa JP, Peeters L, Van Vlierberghe H, Leclercq IA, Canbay A, Dollé L, van Grunsven LA. Macrophage Depletion Attenuates Extracellular Matrix Deposition and Ductular Reaction in a Mouse Model of Chronic Cholangiopathies. PLoS One. 2016; 11(9):e0162286. PMID: 27618307; PMCID: PMC5019458.
    26. Canbay A, Sowa JP, Syn WK, Treckmann J. NASH Cirrhosis - the New Burden in Liver Transplantation: How Should It Be Managed? Visc Med. 2016 Aug; 32(4):234-238. PMID: 27722159.
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    27. Swiderska-Syn M, Xie G, Michelotti GA, Jewell ML, Premont RT, Syn WK, Diehl AM. Hedgehog regulates yes-associated protein 1 in regenerating mouse liver. Hepatology. 2016 07; 64(1):232-44. PMID: 26970079; PMCID: PMC4917408 [Available on 07/01/17].
    28. Chen YY, Jeffery HC, Hunter S, Bhogal R, Birtwistle J, Braitch MK, Roberts S, Ming M, Hannah J, Thomas C, Adali G, Hübscher SG, Syn WK, Afford S, Lalor PF, Adams DH, Oo YH. Human intrahepatic regulatory T cells are functional, require IL-2 from effector cells for survival, and are susceptible to Fas ligand-mediated apoptosis. Hepatology. 2016 07; 64(1):138-50. PMID: 26928938; PMCID: PMC4950043.
    29. Kothari AN, Arffa ML, Chang V, Blackwell RH, Syn WK, Zhang J, Mi Z, Kuo PC. Osteopontin-A Master Regulator of Epithelial-Mesenchymal Transition. J Clin Med. 2016 Mar 23; 5(4). PMID: 27023622; PMCID: PMC4850462.
    30. Coombes JD, Choi SS, Swiderska-Syn M, Manka P, Reid DT, Palma E, Briones-Orta MA, Xie G, Younis R, Kitamura N, Della Peruta M, Bitencourt S, Dollé L, Oo YH, Mi Z, Kuo PC, Williams R, Chokshi S, Canbay A, Claridge LC, Eksteen B, Diehl AM, Syn WK. Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis. Biochim Biophys Acta. 2016 Jan; 1862(1):135-44. PMID: 26529285; PMCID: PMC4756594 [Available on 01/01/17].
    31. Pereira TA, Syn WK, Machado MV, Vidigal PV, Resende V, Voieta I, Xie G, Otoni A, Souza MM, Santos ET, Chan IS, Trindade GV, Choi SS, Witek RP, Pereira FE, Secor WE, Andrade ZA, Lambertucci JR, Diehl AM. Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni. Clin Sci (Lond). 2015 Nov; 129(10):875-83. PMID: 26201095; PMCID: PMC4558314.
    32. Anastasiou O, Sydor S, Sowa JP, Manka P, Katsounas A, Syn WK, Führer D, Gieseler RK, Bechmann LP, Gerken G, Moeller LC, Canbay A. Higher Thyroid-Stimulating Hormone, Triiodothyronine and Thyroxine Values Are Associated with Better Outcome in Acute Liver Failure. PLoS One. 2015; 10(7):e0132189. PMID: 26147961; PMCID: PMC4493082.
    33. Coombes JD, Syn WK. Differential osteopontin functions: The role of osteopontin isoforms. Hepatology. 2015 Jul; 62(1):323-4. PMID: 25302684.
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    34. Manka P, Bechmann LP, Coombes JD, Thodou V, Schlattjan M, Kahraman A, Syn WK, Saner F, Gerken G, Baba H, Verheyen J, Timm J, Canbay A. Hepatitis E Virus Infection as a Possible Cause of Acute Liver Failure in Europe. Clin Gastroenterol Hepatol. 2015 Oct; 13(10):1836-1842.e2; quiz e157-8. PMID: 25912835.
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    35. Tai FW, Syn WK, Alazawi W. Practical approach to non-alcoholic fatty liver disease in patients with diabetes. Diabet Med. 2015 Sep; 32(9):1121-33. PMID: 25683343.
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    36. Best J, Manka P, Syn WK, Dollé L, van Grunsven LA, Canbay A. Role of liver progenitors in liver regeneration. Hepatobiliary Surg Nutr. 2015 Feb; 4(1):48-58. PMID: 25713804; PMCID: PMC4318954.
    37. Weber CE, Kothari AN, Wai PY, Li NY, Driver J, Zapf MA, Franzen CA, Gupta GN, Osipo C, Zlobin A, Syn WK, Zhang J, Kuo PC, Mi Z. Osteopontin mediates an MZF1-TGF-ß1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer. Oncogene. 2015 Sep 10; 34(37):4821-33. PMID: 25531323; PMCID: PMC4476970.
    38. Dechêne A, Sowa JP, Schlattjan M, Wree A, Blomeyer S, Best J, Maldonado EJ, Bechmann LP, Gerken G, Baba HA, Syn WK, Canbay A. Mini-laparoscopy guided liver biopsy increases diagnostic accuracy in acute liver failure. Digestion. 2014; 90(4):240-7. PMID: 25531058.
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    39. Beilfuss A, Sowa JP, Sydor S, Beste M, Bechmann LP, Schlattjan M, Syn WK, Wedemeyer I, Mathé Z, Jochum C, Gerken G, Gieseler RK, Canbay A. Vitamin D counteracts fibrogenic TGF-ß signalling in human hepatic stellate cells both receptor-dependently and independently. Gut. 2015 May; 64(5):791-9. PMID: 25134788.
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    40. Manka P, Olliges V, Bechmann LP, Schlattjan M, Jochum C, Treckmann JW, Saner FH, Gerken G, Syn WK, Canbay A. Low levels of blood lipids are associated with etiology and lethal outcome in acute liver failure. PLoS One. 2014; 9(7):e102351. PMID: 25025159; PMCID: PMC4099314.
    41. Coombes JD, Swiderska-Syn M, Dollé L, Reid D, Eksteen B, Claridge L, Briones-Orta MA, Shetty S, Oo YH, Riva A, Chokshi S, Papa S, Mi Z, Kuo PC, Williams R, Canbay A, Adams DH, Diehl AM, van Grunsven LA, Choi SS, Syn WK. Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice. Gut. 2015 Jul; 64(7):1120-31. PMID: 24902765; PMCID: PMC4487727.
    42. Choi SS, Claridge LC, Jhaveri R, Swiderska-Syn M, Clark P, Suzuki A, Pereira TA, Mi Z, Kuo PC, Guy CD, Pereira FE, Diehl AM, Patel K, Syn WK. Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication. Clin Sci (Lond). 2014 Jun; 126(12):845-55. PMID: 24438228; PMCID: PMC4055032.
    43. Dechêne A, Jochum C, Fingas C, Paul A, Heider D, Syn WK, Gerken G, Canbay A, Zöpf T. Endoscopic management is the treatment of choice for bile leaks after liver resection. Gastrointest Endosc. 2014 Oct; 80(4):626-633.e1. PMID: 24796959.
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    44. Armstrong MJ, Adams LA, Canbay A, Syn WK. Extrahepatic complications of nonalcoholic fatty liver disease. Hepatology. 2014 Mar; 59(3):1174-97. PMID: 24002776.
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    45. Karaca G, Swiderska-Syn M, Xie G, Syn WK, Krüger L, Machado MV, Garman K, Choi SS, Michelotti GA, Burkly LC, Ochoa B, Diehl AM. TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice. PLoS One. 2014; 9(1):e83987. PMID: 24416188; PMCID: PMC3886973.
    46. Syn WK. Repair-associated inflammation in nonalcoholic fatty liver disease. Clin Med (Lond). 2013 Dec; 13 Suppl 6:s15-9. PMID: 24298175.
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    47. Swiderska-Syn M, Syn WK, Xie G, Krüger L, Machado MV, Karaca G, Michelotti GA, Choi SS, Premont RT, Diehl AM. Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy. Gut. 2014 Aug; 63(8):1333-44. PMID: 24173292; PMCID: PMC4006344.
    48. Kahraman A, Sowa JP, Schlattjan M, Sydor S, Pronadl M, Wree A, Beilfuss A, Kilicarslan A, Altinbas A, Bechmann LP, Syn WK, Gerken G, Canbay A. Fetuin-A mRNA expression is elevated in NASH compared with NAFL patients. Clin Sci (Lond). 2013 Oct; 125(8):391-400. PMID: 23627434.
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    49. Best J, Dollé L, Manka P, Coombes J, van Grunsven LA, Syn WK. Role of liver progenitors in acute liver injury. Front Physiol. 2013 Sep 26; 4:258. PMID: 24133449; PMCID: PMC3783932.
    50. Michelotti GA, Xie G, Swiderska M, Choi SS, Karaca G, Krüger L, Premont R, Yang L, Syn WK, Metzger D, Diehl AM. Smoothened is a master regulator of adult liver repair. J Clin Invest. 2013 Jun; 123(6):2380-94. PMID: 23563311; PMCID: PMC3668809.
    51. Coombes J, Syn WK. Utility of osteopontin in lineage tracing experiments. Gastroenterology. 2013 Jul; 145(1):254-5. PMID: 23727494.
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    52. Liaskou E, Zimmermann HW, Li KK, Oo YH, Suresh S, Stamataki Z, Qureshi O, Lalor PF, Shaw J, Syn WK, Curbishley SM, Adams DH. Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics. Hepatology. 2013 Jan; 57(1):385-98. PMID: 22911542; PMCID: PMC4194426.
    53. Pereira TA, Xie G, Choi SS, Syn WK, Voieta I, Lu J, Chan IS, Swiderska M, Amaral KB, Antunes CM, Secor WE, Witek RP, Lambertucci JR, Pereira FL, Diehl AM. Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni. Liver Int. 2013 Jan; 33(1):149-61. PMID: 23121638; PMCID: PMC3518740.
    54. Coombes JD, Coombes J, Syn WK. Hedgehog-responsive progenitors: predictors of liver outcomes? Hepatology. 2012 Nov; 56(5):2010-1; author reply 2011. PMID: 22605508.
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    55. Chan IS, Guy CD, Chen Y, Lu J, Swiderska-Syn M, Michelotti GA, Karaca G, Xie G, Krüger L, Syn WK, Anderson BR, Pereira TA, Choi SS, Baldwin AS, Diehl AM. Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma. Cancer Res. 2012 Dec 15; 72(24):6344-50. PMID: 23066040; PMCID: PMC3525764.
    56. Syn WK, Agboola KM, Swiderska M, Michelotti GA, Liaskou E, Pang H, Xie G, Philips G, Chan IS, Karaca GF, Pereira Tde A, Chen Y, Mi Z, Kuo PC, Choi SS, Guy CD, Abdelmalek MF, Diehl AM. NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease. Gut. 2012 Sep; 61(9):1323-9. PMID: 22427237; PMCID: PMC3578424.
    57. Xie G, Choi SS, Syn WK, Michelotti GA, Swiderska M, Karaca G, Chan IS, Chen Y, Diehl AM. Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation. Gut. 2013 Feb; 62(2):299-309. PMID: 22362915; PMCID: PMC3595101.
    58. Philips GM, Chan IS, Swiderska M, Schroder VT, Guy C, Karaca GF, Moylan C, Venkatraman T, Feuerlein S, Syn WK, Jung Y, Witek RP, Choi S, Michelotti GA, Rangwala F, Merkle E, Lascola C, Diehl AM. Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer. PLoS One. 2011; 6(9):e23943. PMID: 21912653; PMCID: PMC3166282.
    59. Kahraman A, Fingas CD, Syn WK, Gerken G, Canbay A. Role of stress-induced NKG2D ligands in liver diseases. Liver Int. 2012 Mar; 32(3):370-82. PMID: 22097967.
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    60. Seth D, Haber PS, Syn WK, Diehl AM, Day CP. Pathogenesis of alcohol-induced liver disease: classical concepts and recent advances. J Gastroenterol Hepatol. 2011 Jul; 26(7):1089-105. PMID: 21545524.
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    61. El-Ghaiesh S, Sanderson JP, Farrell J, Lavergne SN, Syn WK, Pirmohamed M, Park BK, Naisbitt DJ. Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury. J Allergy Clin Immunol. 2011 Sep; 128(3):680-3. PMID: 21596425.
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    62. El-Ghaiesh S, Sanderson JP, Farrell J, Lavergne SN, Syn WK, Pirmohamed M, Park BK, Naisbitt DJ. Trimethoprim stimulates T-cells through metabolism-dependent and -independent pathways. Chem Res Toxicol. 2011 Jun 20; 24(6):791-3. PMID: 21491947.
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    63. Delgado I, Fresnedo O, Iglesias A, Rueda Y, Syn WK, Zubiaga AM, Ochoa B. A role for transcription factor E2F2 in hepatocyte proliferation and timely liver regeneration. Am J Physiol Gastrointest Liver Physiol. 2011 Jul; 301(1):G20-31. PMID: 21527726.
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    64. Ertle J, Dechêne A, Sowa JP, Penndorf V, Herzer K, Kaiser G, Schlaak JF, Gerken G, Syn WK, Canbay A. Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis. Int J Cancer. 2011 May 15; 128(10):2436-43. PMID: 21128245.
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    65. Wree A, Dechêne A, Herzer K, Hilgard P, Syn WK, Gerken G, Canbay A. Steroid and ursodesoxycholic Acid combination therapy in severe drug-induced liver injury. Digestion. 2011; 84(1):54-9. PMID: 21304237.
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    66. Choi SS, Omenetti A, Syn WK, Diehl AM. The role of Hedgehog signaling in fibrogenic liver repair. Int J Biochem Cell Biol. 2011 Feb; 43(2):238-44. PMID: 21056686; PMCID: PMC3022074.
    67. Syn WK, Choi SS, Liaskou E, Karaca GF, Agboola KM, Oo YH, Mi Z, Pereira TA, Zdanowicz M, Malladi P, Chen Y, Moylan C, Jung Y, Bhattacharya SD, Teaberry V, Omenetti A, Abdelmalek MF, Guy CD, Adams DH, Kuo PC, Michelotti GA, Whitington PF, Diehl AM. Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. Hepatology. 2011 Jan; 53(1):106-15. PMID: 20967826; PMCID: PMC3025083.
    68. Choi SS, Syn WK, Karaca GF, Omenetti A, Moylan CA, Witek RP, Agboola KM, Jung Y, Michelotti GA, Diehl AM. Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway. J Biol Chem. 2010 Nov 19; 285(47):36551-60. PMID: 20843817; PMCID: PMC2978583.
    69. Pereira Tde A, Witek RP, Syn WK, Choi SS, Bradrick S, Karaca GF, Agboola KM, Jung Y, Omenetti A, Moylan CA, Yang L, Fernandez-Zapico ME, Jhaveri R, Shah VH, Pereira FE, Diehl AM. Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma. Lab Invest. 2010 Dec; 90(12):1690-703. PMID: 20697376; PMCID: PMC2980808.
    70. Choi SS, Witek RP, Yang L, Omenetti A, Syn WK, Moylan CA, Jung Y, Karaca GF, Teaberry VS, Pereira TA, Wang J, Ren XR, Diehl AM. Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells. Hepatology. 2010 Jul; 52(1):278-90. PMID: 20578145; PMCID: PMC2920128.
    71. Syn WK, Oo YH, Pereira TA, Karaca GF, Jung Y, Omenetti A, Witek RP, Choi SS, Guy CD, Fearing CM, Teaberry V, Pereira FE, Adams DH, Diehl AM. Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease. Hepatology. 2010 Jun; 51(6):1998-2007. PMID: 20512988; PMCID: PMC2920131.
    72. Jung Y, Witek RP, Syn WK, Choi SS, Omenetti A, Premont R, Guy CD, Diehl AM. Signals from dying hepatocytes trigger growth of liver progenitors. Gut. 2010 May; 59(5):655-65. PMID: 20427400; PMCID: PMC3632642.
    73. Ochoa B, Syn WK, Delgado I, Karaca GF, Jung Y, Wang J, Zubiaga AM, Fresnedo O, Omenetti A, Zdanowicz M, Choi SS, Diehl AM. Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice. Hepatology. 2010 May; 51(5):1712-23. PMID: 20432255; PMCID: PMC2920129.
    74. Syn WK, Oo YH. Supporting evidence for natural killer T cell accumulation in progressive nonalcoholic fatty liver disease? Hepatology. 2010 Jan; 51(1):345-6; author reply 346. PMID: 20034038.
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    75. Witek RP, Stone WC, Karaca FG, Syn WK, Pereira TA, Agboola KM, Omenetti A, Jung Y, Teaberry V, Choi SS, Guy CD, Pollard J, Charlton P, Diehl AM. Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. Hepatology. 2009 Nov; 50(5):1421-30. PMID: 19676126.
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    76. Syn WK, Choi SS, Diehl AM. Apoptosis and cytokines in non-alcoholic steatohepatitis. Clin Liver Dis. 2009 Nov; 13(4):565-80. PMID: 19818305; PMCID: PMC2766093.
    77. Choi SS, Omenetti A, Witek RP, Moylan CA, Syn WK, Jung Y, Yang L, Sudan DL, Sicklick JK, Michelotti GA, Rojkind M, Diehl AM. Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297(6):G1093-106. PMID: 19815628; PMCID: PMC2850083.
    78. Farmer AD, Cook MJ, Bruckner Holt CE, Syn WK, Lewis MJ. Leucocyte esterase reagent strips for the diagnosis of spontaneous bacterial peritonitis: a systematic review by Koulaouzidis et al. Eur J Gastroenterol Hepatol. 2009 Sep; 21(9):1102. PMID: 19672155.
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    79. Omenetti A, Syn WK, Jung Y, Francis H, Porrello A, Witek RP, Choi SS, Yang L, Mayo MJ, Gershwin ME, Alpini G, Diehl AM. Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production. Hepatology. 2009 Aug; 50(2):518-27. PMID: 19575365; PMCID: PMC2722691.
    80. Syn WK, Jung Y, Omenetti A, Abdelmalek M, Guy CD, Yang L, Wang J, Witek RP, Fearing CM, Pereira TA, Teaberry V, Choi SS, Conde-Vancells J, Karaca GF, Diehl AM. Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. Gastroenterology. 2009 Oct; 137(4):1478-1488.e8. PMID: 19577569; PMCID: PMC2757536.
    81. Syn WK, Witek RP, Curbishley SM, Jung Y, Choi SS, Enrich B, Omenetti A, Agboola KM, Fearing CM, Tilg H, Adams DH, Diehl AM. Role for hedgehog pathway in regulating growth and function of invariant NKT cells. Eur J Immunol. 2009 Jul; 39(7):1879-92. PMID: 19544307; PMCID: PMC2965448.
    82. Talbot-Smith A, Syn WK, MacQuillan G, Neil D, Elias E, Ryan P. Familial idiopathic pulmonary fibrosis in association with bone marrow hypoplasia and hepatic nodular regenerative hyperplasia: a new "trimorphic" syndrome. Thorax. 2009 May; 64(5):440-3. PMID: 19401489.
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    83. Farmer AD, Saadeddin A, Holt CE, Bateman JM, Ahmed M, Syn WK. Portal vein thrombosis in the district general hospital: management and clinical outcomes. Eur J Gastroenterol Hepatol. 2009 May; 21(5):517-21. PMID: 19262399.
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    84. Syn WK, Teaberry V, Choi SS, Diehl AM. Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis. Semin Liver Dis. 2009 May; 29(2):200-10. PMID: 19387919; PMCID: PMC3644873.
    85. Syn WK, Yang L, Chiang DJ, Qian Y, Jung Y, Karaca G, Choi SS, Witek RP, Omenetti A, Pereira TA, Diehl AM. Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice. Liver Int. 2009 Sep; 29(8):1262-72. PMID: 19490416; PMCID: PMC3610179.
    86. Syn WK, Palejwala AA. Anicteric cholestasis: an unusual presentation of myotonic dystrophy. Intern Med J. 2009 Mar; 39(3):206-7. PMID: 19383073.
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    87. Kos K, Syn WK, Lewandowski KC, Bennett J, Nwokolo CU, O'Hare JP, Randeva H. Comparison of maternal ghrelin and leptin in healthy mothers and mothers with Type 1 diabetes. Diabet Med. 2008 Dec; 25(12):1400-5. PMID: 19046237.
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    88. Witek RP, Yang L, Liu R, Jung Y, Omenetti A, Syn WK, Choi SS, Cheong Y, Fearing CM, Agboola KM, Chen W, Diehl AM. Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. Gastroenterology. 2009 Jan; 136(1):320-330.e2. PMID: 19013163; PMCID: PMC3724240.
    89. Omenetti A, Porrello A, Jung Y, Yang L, Popov Y, Choi SS, Witek RP, Alpini G, Venter J, Vandongen HM, Syn WK, Baroni GS, Benedetti A, Schuppan D, Diehl AM. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest. 2008 Oct; 118(10):3331-42. PMID: 18802480; PMCID: PMC2542850.
    90. Shetty S, Holt AP, Syn WK, Fox CP, Gunson B, Neil D, Haydon G. Haematological malignancies presenting with acute liver injury: a single-centre experience. QJM. 2008 Dec; 101(12):949-53. PMID: 18812406.
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    91. Oo YH, Syn WK. Persistent pyrexia post-liver transplantation: a unique case of pericardial tuberculosis. Eur J Intern Med. 2008 Dec; 19(8):e88-9. PMID: 19046713.
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    92. Bruckner Holt CE, Farmer AD, Syn W, Shah T, Townson G. Mesothelioma - "not just in the chest". Ulster Med J. 2008 May; 77(2):133-4. PMID: 18711629; PMCID: PMC2516435.
    93. Syn WK, Nightingale P, Bateman JM. Nonalcoholic fatty liver disease in a district general hospital: clinical presentation and risk factors. Hepatol Int. 2008 Jun; 2(2):190-5. PMID: 19669303; PMCID: PMC2716851.
    94. Brostoff JM, Bhati CS, Syn WK. Late venous outflow obstruction after liver transplant: The 'piggy-back' syndrome. Eur J Intern Med. 2008 Jul; 19(5):374-6. PMID: 18549945.
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    95. Syn WK, Bruckner-Holt C, Farmer A, Howdle S, Bateman J. Liver biopsy in a district general hospital: changes over two decades. World J Gastroenterol. 2007 Oct 28; 13(40):5336-42. PMID: 17879403; PMCID: PMC4171323.
    96. Syn WK, Nightingale P, Gunson B, Hubscher SG, Neuberger JM. Natural history of unexplained chronic hepatitis after liver transplantation. Liver Transpl. 2007 Jul; 13(7):984-9. PMID: 17520743.
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    97. Short K, Syn WK, Haydon G. Sulphasalazine-induced hypersensitivity syndrome: a relapsing disorder and the role of human herpes virus-6. Eur J Gastroenterol Hepatol. 2007 Feb; 19(2):181-2. PMID: 17273007.
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    98. Thurairajah PH, Syn WK, Neil DA, Stell D, Haydon G. Orlistat (Xenical)-induced subacute liver failure. Eur J Gastroenterol Hepatol. 2005 Dec; 17(12):1437-8. PMID: 16292105.
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    99. Syn WK, Tandon U, Ahmed MM. Colonoscopy in the very elderly is safe and worthwhile. Age Ageing. 2005 Sep; 34(5):510-3. PMID: 16107458.
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    100. Sajjad A, Mottershead M, Syn WK, Jones R, Smith S, Nwokolo CU. Ciprofloxacin suppresses bacterial overgrowth, increases fasting insulin but does not correct low acylated ghrelin concentration in non-alcoholic steatohepatitis. Aliment Pharmacol Ther. 2005 Aug 15; 22(4):291-9. PMID: 16097995.
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    101. Syn WK, Naisbitt DJ, Holt AP, Pirmohamed M, Mutimer DJ. Carbamazepine-induced acute liver failure as part of the DRESS syndrome. Int J Clin Pract. 2005 Aug; 59(8):988-91. PMID: 16033627.
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    102. Syn WK, Ahmed MM. Genetic haemochromatosis presenting as porphyria cutanea tarda. Int J Clin Pract Suppl. 2005 Apr; (147):48-50. PMID: 15875621.
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    103. Syn WK, Patel M, Ahmed MM. Metallic stents in large bowel obstruction: experience in a District General Hospital. Colorectal Dis. 2005 Jan; 7(1):22-6. PMID: 15606580.
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    104. Syn WK, Ahmed MM. Esophageal involvement in cicatricial pemphigoid: a rare cause of dysphagia. Dis Esophagus. 2004; 17(2):180-2. PMID: 15230736.
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    105. Syn WK, Skander MP, Ahmed MM. Variceal ligator cap dislodgment, and retrieval techniques. Endoscopy. 2003 Sep; 35(9):796; author reply 796-7. PMID: 12929037.
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    106. Syn WK, Singh R, Ahmed MM. Esophageal melanoma. Gastrointest Endosc. 2003 Aug; 58(2):251. PMID: 12872096.
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    107. Sington JD, Syn WK, Suvarna SK, Rassl DM, Jenkins RC, Weetman AP, Ross RJ. Lack of association between thyroid and adrenal nodules: a histological study. J Endocrinol Invest. 1999 Apr; 22(4):262-5. PMID: 10342359.
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