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William Clyde Griffin

Title
InstitutionMedical University of South Carolina
DepartmentPsychiatry and Behavioral Sciences
AddressP.O. Box MSC 861
629 F
Thurmond Gazes - 30 Courtenay Drive
Phone843-792-4324
Fax843-792-7353
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    Collapse Overview 
    Collapse overview
    Dr. Griffin uses mouse models to study the neurobiological adaptations in the brain that underlie addiction. In particular, areas of active investigation include examining the glutamatergic and dopaminergic signaling systems in brain regions like the nucleus accumbens and dorsolateral striatum which are known to be involved in the regulation of alcohol drinking and other drug taking behaviors.

    Methods:
    stereotaxic surgery in mice
    jugular catheter implantation in mice
    microinjection procedures
    microdialysis procedures
    HPLC techniques with electrochemical and fluorescent detection
    gas chromatography with flame ionization detection

    Behavioral Methods:
    models of free-choice ethanol drinking
    operant self-administration procedures with ethanol and stimulants
    conditioned place preference with ethanol and stimulants
    drug discrimination procedures with ethanol and stimulants
    conditioned taste aversion procedures
    measures of ataxia

    Collapse keywords
    alcohol, cocaine, drinking, nucleus accumbens, glutamate

    Collapse ORNG Applications 
    Collapse studies/trials

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Solomon MG, Griffin WC, Lopez MF, Becker HC. Brain Regional and Temporal Changes in BDNF mRNA and microRNA-206 Expression in Mice Exposed to Repeated Cycles of Chronic Intermittent Ethanol and Forced Swim Stress. Neuroscience. 2019 05 15; 406:617-625. PMID: 30790666.
      View in: PubMed
    2. Anderson RI, Lopez MF, Griffin WC, Haun HL, Bloodgood DW, Pati D, Boyt KM, Kash TL, Becker HC. Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice. Neuropsychopharmacology. 2019 05; 44(6):1084-1092. PMID: 30555162.
      View in: PubMed
    3. Haun HL, Griffin WC, Lopez MF, Solomon MG, Mulholland PJ, Woodward JJ, McGinty JF, Ron D, Becker HC. Increasing Brain-Derived Neurotrophic Factor (BDNF) in medial prefrontal cortex selectively reduces excessive drinking in ethanol dependent mice. Neuropharmacology. 2018 09 15; 140:35-42. PMID: 30056122.
      View in: PubMed
    4. Bobadilla AC, Heinsbroek JA, Gipson CD, Griffin WC, Fowler CD, Kenny PJ, Kalivas PW. Corticostriatal plasticity, neuronal ensembles, and regulation of drug-seeking behavior. Prog Brain Res. 2017; 235:93-112. PMID: 29054293.
      View in: PubMed
    5. Laguesse S, Morisot N, Shin JH, Liu F, Adrover MF, Sakhai SA, Lopez MF, Phamluong K, Griffin WC, Becker HC, Bender KJ, Alvarez VA, Ron D. Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward. Neuron. 2017 Sep 27; 96(1):145-159.e8. PMID: 28890345.
      View in: PubMed
    6. King CE, Griffin WC, Luderman LN, Kates MM, McGinty JF, Becker HC. Oxytocin Reduces Ethanol Self-Administration in Mice. Alcohol Clin Exp Res. 2017 May; 41(5):955-964. PMID: 28212464.
      View in: PubMed
    7. Heinsbroek JA, Neuhofer DN, Griffin WC, Siegel GS, Bobadilla AC, Kupchik YM, Kalivas PW. Loss of Plasticity in the D2-Accumbens Pallidal Pathway Promotes Cocaine Seeking. J Neurosci. 2017 01 25; 37(4):757-767. PMID: 28123013.
      View in: PubMed
    8. Smith ACW, Scofield MD, Heinsbroek JA, Gipson CD, Neuhofer D, Roberts-Wolfe DJ, Spencer S, Garcia-Keller C, Stankeviciute NM, Smith RJ, Allen NP, Lorang MR, Griffin WC, Boger HA, Kalivas PW. Accumbens nNOS Interneurons Regulate Cocaine Relapse. J Neurosci. 2017 01 25; 37(4):742-756. PMID: 28123012.
      View in: PubMed
    9. Efird JT, Griffin W, O'Neal WT, Davies SW, Shiue KY, Grzybowski M, Kindell LC, Kypson AP, Bowling M, Ferguson TB, Alger L, Crane PB. Long-Term Survival after Cardiac Surgery in Patients with Chronic Obstructive Pulmonary Disease. Am J Crit Care. 2016 05; 25(3):266-76. PMID: 27134234.
      View in: PubMed
    10. May CE, Haun HL, Griffin WC. Sensitization and Tolerance Following Repeated Exposure to Caffeine and Alcohol in Mice. Alcohol Clin Exp Res. 2015 Aug; 39(8):1443-52. PMID: 26136115.
      View in: PubMed
    11. McGuier NS, Griffin WC, Gass JT, Padula AE, Chesler EJ, Mulholland PJ. Kv7 channels in the nucleus accumbens are altered by chronic drinking and are targets for reducing alcohol consumption. Addict Biol. 2016 11; 21(6):1097-1112. PMID: 26104325.
      View in: PubMed
    12. Uys JD, McGuier NS, Gass JT, Griffin WC, Ball LE, Mulholland PJ. Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines. Addict Biol. 2016 May; 21(3):560-74. PMID: 25787124.
      View in: PubMed
    13. Griffin WC, Ramachandra VS, Knackstedt LA, Becker HC. Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport. Front Pharmacol. 2015; 6:27. PMID: 25755641.
      View in: PubMed
    14. Padula AE, Griffin WC, Lopez MF, Nimitvilai S, Cannady R, McGuier NS, Chesler EJ, Miles MF, Williams RW, Randall PK, Woodward JJ, Becker HC, Mulholland PJ. KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. Neuropsychopharmacology. 2015 Jul; 40(8):1928-39. PMID: 25662840.
      View in: PubMed
    15. McGovern R, Luderman L, Knecht K, Griffin WC. Influence of sensitization on the discriminative stimulus effects of methylphenidate in mice. Behav Pharmacol. 2014 Dec; 25(8):766-74. PMID: 25325285.
      View in: PubMed
    16. Griffin WC. Alcohol dependence and free-choice drinking in mice. Alcohol. 2014 May; 48(3):287-93. PMID: 24530006.
      View in: PubMed
    17. Griffin WC, Haun HL, Hazelbaker CL, Ramachandra VS, Becker HC. Increased extracellular glutamate in the nucleus accumbens promotes excessive ethanol drinking in ethanol dependent mice. Neuropsychopharmacology. 2014 Feb; 39(3):707-17. PMID: 24067300.
      View in: PubMed
    18. Hilbert ML, May CE, Griffin WC. Conditioned reinforcement and locomotor activating effects of caffeine and ethanol combinations in mice. Pharmacol Biochem Behav. 2013 Sep; 110:168-73. PMID: 23872371.
      View in: PubMed
    19. Griffin WC. Commentary on Marczinski and colleagues: mixing an energy drink with an alcoholic beverage increases motivation for more alcohol in college students. Alcohol Clin Exp Res. 2013 Feb; 37(2):188-90. PMID: 23127129.
      View in: PubMed
    20. Griffin WC, McGovern RW, Bell GH, Randall PK, Middaugh LD, Patrick KS. Interactive effects of methylphenidate and alcohol on discrimination, conditioned place preference and motor coordination in C57BL/6J mice. Psychopharmacology (Berl). 2013 Feb; 225(3):613-25. PMID: 22955568.
      View in: PubMed
    21. Griffin WC, Nguyen SA, Deleon CP, Middaugh LD. Effects of vigabatrin, an irreversible GABA transaminase inhibitor, on ethanol reinforcement and ethanol discriminative stimuli in mice. Behav Pharmacol. 2012 Apr; 23(2):178-90. PMID: 22336593.
      View in: PubMed
    22. Lopez MF, Griffin WC, Melendez RI, Becker HC. Repeated cycles of chronic intermittent ethanol exposure leads to the development of tolerance to aversive effects of ethanol in C57BL/6J mice. Alcohol Clin Exp Res. 2012 Jul; 36(7):1180-7. PMID: 22309159.
      View in: PubMed
    23. Bell GH, Griffin WC, Patrick KS. Oral and transdermal DL-methylphenidate-ethanol interactions in C57BL/6J mice: potentiation of locomotor activity with oral delivery. Pharmacol Biochem Behav. 2011 Dec; 100(2):264-70. PMID: 21925201.
      View in: PubMed
    24. Carrara-Nascimento PF, Griffin WC, Pastrello DM, Olive MF, Camarini R. Changes in extracellular levels of glutamate in the nucleus accumbens after ethanol-induced behavioral sensitization in adolescent and adult mice. Alcohol. 2011 Aug; 45(5):451-60. PMID: 21570797.
      View in: PubMed
    25. McGovern RW, Middaugh LD, Patrick KS, Griffin WC. The discriminative stimulus properties of methylphenidate in C57BL/6J mice. Behav Pharmacol. 2011 Feb; 22(1):14-22. PMID: 21160424.
      View in: PubMed
    26. Bell GH, Novak AJ, Griffin WC, Patrick KS. Transdermal and oral dl-methylphenidate-ethanol interactions in C57BL/6J mice: transesterification to ethylphenidate and elevation of d-methylphenidate concentrations. J Pharm Sci. 2011 Jul; 100(7):2966-78. PMID: 21240977.
      View in: PubMed
    27. Griffin WC, Novak AJ, Middaugh LD, Patrick KS. The interactive effects of methylphenidate and ethanol on ethanol consumption and locomotor activity in mice. Pharmacol Biochem Behav. 2010 May; 95(3):267-72. PMID: 20122954.
      View in: PubMed
    28. Griffin WC, Lopez MF, Becker HC. Intensity and duration of chronic ethanol exposure is critical for subsequent escalation of voluntary ethanol drinking in mice. Alcohol Clin Exp Res. 2009 Nov; 33(11):1893-900. PMID: 19673744.
      View in: PubMed
    29. Griffin WC, Lopez MF, Yanke AB, Middaugh LD, Becker HC. Repeated cycles of chronic intermittent ethanol exposure in mice increases voluntary ethanol drinking and ethanol concentrations in the nucleus accumbens. Psychopharmacology (Berl). 2009 Jan; 201(4):569-80. PMID: 18791704.
      View in: PubMed
    30. Xiao C, Shao XM, Olive MF, Griffin WC, Li KY, Krnjevic K, Zhou C, Ye JH. Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area. Neuropsychopharmacology. 2009 Jan; 34(2):307-18. PMID: 18596684.
      View in: PubMed
    31. Burattini C, McGeehan AJ, Griffin WC, Gass JT, Kinder JR, Janak PH, Olive MF. A microdialysis study of extracellular levels of acamprosate and naltrexone in the rat brain following acute and repeated administration. Addict Biol. 2008 Mar; 13(1):70-9. PMID: 18269381.
      View in: PubMed
    32. Camarini R, Griffin WC, Yanke AB, Rosalina dos Santos B, Olive MF. Effects of adolescent exposure to cocaine on locomotor activity and extracellular dopamine and glutamate levels in nucleus accumbens of DBA/2J mice. Brain Res. 2008 Feb 08; 1193:34-42. PMID: 18178178.
      View in: PubMed
    33. Griffin WC, Randall PK, Middaugh LD. Intravenous cocaine self-administration: individual differences in male and female C57BL/6J mice. Pharmacol Biochem Behav. 2007 Jun-Jul; 87(2):267-79. PMID: 17561241.
      View in: PubMed
    34. Cook-Easterwood J, Middaugh LD, Griffin WC, Khan I, Tyor WR. Highly active antiretroviral therapy of cognitive dysfunction and neuronal abnormalities in SCID mice with HIV encephalitis. Exp Neurol. 2007 Jun; 205(2):506-12. PMID: 17442303.
      View in: PubMed
    35. Griffin WC, Middaugh LD, Becker HC. Voluntary ethanol drinking in mice and ethanol concentrations in the nucleus accumbens. Brain Res. 2007 Mar 23; 1138:208-13. PMID: 17275791.
      View in: PubMed
    36. Griffin WC, Middaugh LD, Tyor WR. Chronic cocaine exposure in the SCID mouse model of HIV encephalitis. Brain Res. 2007 Feb 23; 1134(1):214-9. PMID: 17189621.
      View in: PubMed
    37. Griffin WC, Middaugh LD. The influence of sex on extracellular dopamine and locomotor activity in C57BL/6J mice before and after acute cocaine challenge. Synapse. 2006 Feb; 59(2):74-81. PMID: 16270301.
      View in: PubMed
    38. Griffin WC, Boger HA, Granholm AC, Middaugh LD. Partial deletion of glial cell line-derived neurotrophic factor (GDNF) in mice: Effects on sucrose reward and striatal GDNF concentrations. Brain Res. 2006 Jan 12; 1068(1):257-60. PMID: 16364262.
      View in: PubMed
    39. Griffin WC, Skinner HD, Birkle DL. Prenatal stress influences 8-OH-DPAT modulated startle responding and [3H]-8-OH-DPAT binding in rats. Pharmacol Biochem Behav. 2005 Jul; 81(3):601-7. PMID: 15932768.
      View in: PubMed
    40. Hilliard JK, Griffin WC. Comment on viral tropical diseases. J Am Acad Dermatol. 2004 Dec; 51(6):1038-9. PMID: 15583619.
      View in: PubMed
    41. Szumlinski KK, Dehoff MH, Kang SH, Frys KA, Lominac KD, Klugmann M, Rohrer J, Griffin W, Toda S, Champtiaux NP, Berry T, Tu JC, Shealy SE, During MJ, Middaugh LD, Worley PF, Kalivas PW. Homer proteins regulate sensitivity to cocaine. Neuron. 2004 Aug 05; 43(3):401-13. PMID: 15294147.
      View in: PubMed
    42. Griffin WC, Middaugh LD, Cook JE, Tyor WR. The severe combined immunodeficient (SCID) mouse model of human immunodeficiency virus encephalitis: deficits in cognitive function. J Neurovirol. 2004 Apr; 10(2):109-15. PMID: 15204929.
      View in: PubMed
    43. Griffin WC, Middaugh LD. Acquisition of lever pressing for cocaine in C57BL/6J mice: effects of prior Pavlovian conditioning. Pharmacol Biochem Behav. 2003 Dec; 76(3-4):543-9. PMID: 14643854.
      View in: PubMed
    44. Griffin WC, Skinner HD, Salm AK, Birkle DL. Mild prenatal stress in rats is associated with enhanced conditioned fear. Physiol Behav. 2003 Jul; 79(2):209-15. PMID: 12834792.
      View in: PubMed
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