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Institution

Wei Jiang

Title
InstitutionMedical University of South Carolina
DepartmentMicrobiology and Immunology
AddressP.O. Box MSC 504
BS208D
Basic Science Building - 173 Ashley Ave.
Phone843-876-2457
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    Dr. Jiang earned her Medical Degree in Internal Medicine and Master Degree in Immunology at Capital Medical University, BeiJing, China, and completed her residency in infectious diseases at DiTan hospital, BeiJing, China. Dr. Jiang did her postdoc research in HIV immunopathogenesis from 2002 to 2008, followed by an instructor position in the field of HIV immunopathogenesis from 2008 to 2012 at Case Western Reserve University. She earned another Master Degree in Epidemiology and Biostatistics at Case Western Reserve University at 2012. Dr. Jiang’s research interests include B and T cell dysfunction in HIV disease (NIH, R01), toll-like receptors and innate immunity, and gender related immunology in healthy individuals, HIV disease and autoimmune diseases such as lupus.

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    Immunopathogenesis of HIV and SLE diseases, innate and adaptive immunities at systemic (periphery) and tissue (e.g., gut mucosa and lymph nodes) sites in healthy individuals and patients with HIV or SLE disease, Human translational clinical research using human blood and tissue samples

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ogunrinde E, Zhou Z, Luo Z, Alekseyenko A, Li QZ, Macedo D, Kamen DL, Oates JC, Gilkeson GS, Jiang W. A link between plasma microbial translocation, microbiome, and autoantibody development in first-degree relatives of systemic lupus erythematosus patients. Arthritis Rheumatol. 2019 May 20. PMID: 31106972.
      View in: PubMed
    2. Luo Z, Li M, Wu Y, Meng Z, Martin L, Zhang L, Ogunrinde E, Zhou Z, Qin S, Wan Z, Westerink MAJ, Warth S, Liu H, Jin P, Stroncek D, Li QZ, Wang E, Wu X, Heath SL, Li Z, Alekseyenko AV, Jiang W. Systemic translocation of Staphylococcus drives autoantibody production in HIV disease. Microbiome. 2019 02 14; 7(1):25. PMID: 30764863.
      View in: PubMed
    3. Luo Z, Ogunrinde E, Li M, Zhang L, Martin L, Zhou Z, Hu Z, Zhang T, Li Z, Zhang J, Su B, Zhang T, Wu H, Ma L, Liao G, Eckard AR, Westerink MAJ, Heath SL, Jiang W. Increased influenza-specific antibody avidity in HIV-infected women compared with HIV-infected men on antiretroviral therapy. AIDS. 2019 Jan 27; 33(1):33-44. PMID: 30234599.
      View in: PubMed
    4. Jiang W. A protocol for quantizing total bacterial 16S rDNA in plasma as a marker of microbial translocation in vivo. Cell Mol Immunol. 2018 Oct; 15(10):937-939. PMID: 29658510.
      View in: PubMed
    5. Zhou Z, Powell AM, Ramakrishnan V, Eckard A, Wagner C, Jiang W. Elevated systemic microbial translocation in pregnant HIV-infected women compared to HIV-uninfected women, and its inverse correlations with plasma progesterone levels. J Reprod Immunol. 2018 Jun; 127:16-18. PMID: 29656181.
      View in: PubMed
    6. Jiang W, Luo Z, Martin L, Wan Z, Fu P, Wagner A, Ling B, Heath SL, Haque A, McRae-Clark A. Drug Use is Associated with Anti-CD4 IgG-mediated CD4+ T Cell Death and Poor CD4+ T Cell Recovery in Viral-suppressive HIV-infected Individuals Under Antiretroviral Therapy. Curr HIV Res. 2018; 16(2):143-150. PMID: 29968539.
      View in: PubMed
    7. Zhou Z, Guille C, Ogunrinde E, Liu R, Luo Z, Powell A, Jiang W. Increased systemic microbial translocation is associated with depression during early pregnancy. J Psychiatr Res. 2018 02; 97:54-57. PMID: 29179013.
      View in: PubMed
    8. Luo Z, Zhou Z, Ogunrinde E, Zhang T, Li Z, Martin L, Wan Z, Wu H, Qin Z, Ou T, Zhang J, Ma L, Liao G, Heath S, Huang L, Jiang W. The effect of plasma auto-IgGs on CD4+ T cell apoptosis and recovery in HIV-infected patients under antiretroviral therapy. J Leukoc Biol. 2017 12; 102(6):1481-1486. PMID: 29030391.
      View in: PubMed
    9. Zhou Z, Zhang L, Ding M, Luo Z, Yuan S, Bansal MB, Gilkeson G, Lang R, Jiang W. Estrogen decreases tight junction protein ZO-1 expression in human primary gut tissues. Clin Immunol. 2017 10; 183:174-180. PMID: 28867253.
      View in: PubMed
    10. Luo Z, Li Z, Martin L, Hu Z, Wu H, Wan Z, Kilby M, Heath SL, Huang L, Jiang W. Increased Natural Killer Cell Activation in HIV-Infected Immunologic Non-Responders Correlates with CD4+ T Cell Recovery after Antiretroviral Therapy and Viral Suppression. PLoS One. 2017; 12(1):e0167640. PMID: 28076376.
      View in: PubMed
    11. Powell AM, Luo Z, Martin L, Wan Z, Ma L, Liao G, Song Y, Li X, Michael Kilby J, Huang L, Jiang W. The induction of CD80 and apoptosis on B cells and CD40L in CD4+ T cells in response to seasonal influenza vaccination distinguishes responders versus non-responders in healthy controls and aviremic ART-treated HIV-infected individuals. Vaccine. 2017 02 01; 35(5):831-841. PMID: 28017428.
      View in: PubMed
    12. Zhou Z, Ding M, Huang L, Gilkeson G, Lang R, Jiang W. Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases. Clin Immunol. 2016 Dec; 173:81-86. PMID: 27620642.
      View in: PubMed
    13. Würsch D, Ormsby CE, Romero-Rodríguez DP, Olvera-García G, Zúñiga J, Jiang W, Pérez-Patrigeon S, Espinosa E. CD38 Expression in a Subset of Memory T Cells Is Independent of Cell Cycling as a Correlate of HIV Disease Progression. Dis Markers. 2016; 2016:9510756. PMID: 27064238.
      View in: PubMed
    14. Luo Z, Ma L, Zhang L, Martin L, Wan Z, Warth S, Kilby A, Gao Y, Bhargava P, Li Z, Wu H, Meissner EG, Li Z, Kilby JM, Liao G, Jiang W. Key differences in B cell activation patterns and immune correlates among treated HIV-infected patients versus healthy controls following influenza vaccination. Vaccine. 2016 Apr 07; 34(16):1945-55. PMID: 26721328.
      View in: PubMed
    15. Zhang L, Li Z, Wan Z, Kilby A, Kilby JM, Jiang W. Humoral immune responses to Streptococcus pneumoniae in the setting of HIV-1 infection. Vaccine. 2015 Aug 26; 33(36):4430-6. PMID: 26141012.
      View in: PubMed
    16. Shive CL, Jiang W, Anthony DD, Lederman MM. Soluble CD14 is a nonspecific marker of monocyte activation. AIDS. 2015 Jun 19; 29(10):1263-5. PMID: 26035325.
      View in: PubMed
    17. Hu Z, Luo Z, Wan Z, Wu H, Li W, Zhang T, Jiang W. HIV-associated memory B cell perturbations. Vaccine. 2015 May 21; 33(22):2524-9. PMID: 25887082.
      View in: PubMed
    18. Jiang W, Zhang L, Lang R, Li Z, Gilkeson G. Sex differences in monocyte activation in systemic lupus erythematosus (SLE). PLoS One. 2014; 9(12):e114589. PMID: 25485543.
      View in: PubMed
    19. Zhang L, Luo Z, Sieg SF, Funderburg NT, Yu X, Fu P, Wu H, Jiao Y, Gao Y, Greenspan NS, Harding CV, Kilby JM, Li Z, Lederman MM, Jiang W. Plasmacytoid dendritic cells mediate synergistic effects of HIV and lipopolysaccharide on CD27+ IgD- memory B cell apoptosis. J Virol. 2014 Oct; 88(19):11430-41. PMID: 25056888.
      View in: PubMed
    20. Jiang W, Gilkeson G. Sex Differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE). J Immunother Appl. 2014 Mar 07; 1:1. PMID: 25309746.
      View in: PubMed
    21. Jiang W, Younes SA, Funderburg NT, Mudd JC, Espinosa E, Davenport MP, Babineau DC, Sieg SF, Lederman MM. Cycling memory CD4+ T cells in HIV disease have a diverse T cell receptor repertoire and a phenotype consistent with bystander activation. J Virol. 2014 May; 88(10):5369-80. PMID: 24522925.
      View in: PubMed
    22. Jiang W, Ogretmen B. Autophagy paradox and ceramide. Biochim Biophys Acta. 2014 May; 1841(5):783-92. PMID: 24055889.
      View in: PubMed
    23. Yu X, Li Z, Zhou Z, Kilby JM, Jiang W. Microbial TLR Agonists and Humoral Immunopathogenesis in HIV Disease. Epidemiology (Sunnyvale). 2013 Feb 02; 3:120. PMID: 24795844.
      View in: PubMed
    24. Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Selvam SP, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, Bielawski J, Ogretmen B. Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nat Chem Biol. 2012 Oct; 8(10):831-8. PMID: 22922758.
      View in: PubMed
    25. Jiang W. Microbial Translocation and B Cell Dysfunction in Human Immunodeficiency Virus Disease. Am J Immunol. 2012; 8(2):44-51. PMID: 23869197.
      View in: PubMed
    26. Meyers-Needham M, Ponnusamy S, Gencer S, Jiang W, Thomas RJ, Senkal CE, Ogretmen B. Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells. EMBO Mol Med. 2012 Feb; 4(2):78-92. PMID: 22180294.
      View in: PubMed
    27. Xu L, Muller JG, Withers PR, Kappler C, Jiang W, Menick DR. Role of MAP kinases in the Na+/Ca2+ exchanger gene expression in feline adult cardiocytes. Ann N Y Acad Sci. 2002 Nov; 976:285-7. PMID: 12502571.
      View in: PubMed
    28. Menick DR, Xu L, Kappler C, Jiang W, Withers P, Shepherd N, Conway SJ, Müller JG. Pathways regulating Na+/Ca2+ exchanger expression in the heart. Ann N Y Acad Sci. 2002 Nov; 976:237-47. PMID: 12502566.
      View in: PubMed
    29. Laser M, Willey CD, Jiang W, Cooper G, Menick DR, Zile MR, Kuppuswamy D. Integrin activation and focal complex formation in cardiac hypertrophy. J Biol Chem. 2000 Nov 10; 275(45):35624-30. PMID: 10958798.
      View in: PubMed
    30. Ragaiey T, Ma JX, Jiang WJ, Greene W, Seigel GM, Stewart WC. L-deprenyl protects injured retinal precursor cells in vitro. J Ocul Pharmacol Ther. 1997 Oct; 13(5):479-88. PMID: 9326730.
      View in: PubMed
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