Thomas A. Kirkland

Title
InstitutionMedical University of South Carolina
DepartmentUrology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Killoran MP, Levin S, Boursier ME, Zimmerman K, Hurst R, Hall MP, Machleidt T, Kirkland TA, Friedman Ohana R. An Integrated Approach toward NanoBRET Tracers for Analysis of GPCR Ligand Engagement. Molecules. 2021 May 12; 26(10). PMID: 34065854.
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    2. Hall MP, Kincaid VA, Jost EA, Smith TP, Hurst R, Forsyth SK, Fitzgerald C, Ressler VT, Zimmermann K, Lazar D, Wood MG, Wood KV, Kirkland TA, Encell LP, Machleidt T, Dart ML. Toward a Point-of-Need Bioluminescence-Based Immunoassay Utilizing a Complete Shelf-Stable Reagent. Anal Chem. 2021 03 30; 93(12):5177-5184. PMID: 33730483.
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    3. Benlian BR, Klier PEZ, Martinez KN, Schwinn MK, Kirkland TA, Miller EW. Small Molecule-Protein Hybrid for Voltage Imaging via Quenching of Bioluminescence. ACS Sens. 2021 05 28; 6(5):1857-1863. PMID: 33723996.
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    4. Friedman Ohana R, Levin S, Hurst R, Rosenblatt MM, Zimmerman K, Machleidt T, Wood KV, Kirkland TA. Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 02 19; 16(2):404-413. PMID: 33543920.
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    5. Gaspar N, Walker JR, Zambito G, Marella-Panth K, Lowik C, Kirkland TA, Mezzanotte L. Evaluation of NanoLuc substrates for bioluminescence imaging of transferred cells in mice. J Photochem Photobiol B. 2021 Mar; 216:112128. PMID: 33529963.
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    6. Zambito G, Hall MP, Wood MG, Gaspar N, Ridwan Y, Stellari FF, Shi C, Kirkland TA, Encell LP, Löwik C, Mezzanotte L. Red-shifted click beetle luciferase mutant expands the multicolor bioluminescent palette for deep tissue imaging. iScience. 2021 Jan 22; 24(1):101986. PMID: 33490896.
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    7. Shi C, Killoran MP, Hall MP, Otto P, Wood MG, Strauss E, Encell LP, Machleidt T, Wood KV, Kirkland TA. 5,5-Dialkylluciferins are thermal stable substrates for bioluminescence-based detection systems. PLoS One. 2020; 15(12):e0243747. PMID: 33315907.
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    8. Zambito G, Gaspar N, Ridwan Y, Hall MP, Shi C, Kirkland TA, Encell LP, Löwik C, Mezzanotte L. Evaluating Brightness and Spectral Properties of Click Beetle and Firefly Luciferases Using Luciferin Analogues: Identification of Preferred Pairings of Luciferase and Substrate for In Vivo Bioluminescence Imaging. Mol Imaging Biol. 2020 12; 22(6):1523-1531. PMID: 32926287.
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    9. Gaspar N, Zambito G, Dautzenberg IJC, Cramer SJ, Hoeben RC, Lowik C, Walker JR, Kirkland TA, Smith TP, van Weerden WM, de Vrij J, Mezzanotte L. NanoBiT System and Hydrofurimazine for Optimized Detection of Viral Infection in Mice-A Novel in Vivo Imaging Platform. Int J Mol Sci. 2020 Aug 15; 21(16). PMID: 32824188.
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    10. Su Y, Walker JR, Park Y, Smith TP, Liu LX, Hall MP, Labanieh L, Hurst R, Wang DC, Encell LP, Kim N, Zhang F, Kay MA, Casey KM, Majzner RG, Cochran JR, Mackall CL, Kirkland TA, Lin MZ. Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals. Nat Methods. 2020 08; 17(8):852-860. PMID: 32661427.
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    11. Boursier ME, Levin S, Zimmerman K, Machleidt T, Hurst R, Butler BL, Eggers CT, Kirkland TA, Wood KV, Friedman Ohana R. The luminescent HiBiT peptide enables selective quantitation of G protein-coupled receptor ligand engagement and internalization in living cells. J Biol Chem. 2020 04 10; 295(15):5124-5135. PMID: 32107310.
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    12. Friedman Ohana R, Hurst R, Rosenblatt M, Levin S, Machleidt T, Kirkland TA, Encell LP, Robers MB, Wood KV. Utilizing a Simple Method for Stoichiometric Protein Labeling to Quantify Antibody Blockade. Sci Rep. 2019 05 07; 9(1):7046. PMID: 31065015.
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    13. Dart ML, Machleidt T, Jost E, Schwinn MK, Robers MB, Shi C, Kirkland TA, Killoran MP, Wilkinson JM, Hartnett JR, Zimmerman K, Wood KV. Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift. ACS Med Chem Lett. 2018 Jun 14; 9(6):546-551. PMID: 29937980.
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    14. Hall MP, Woodroofe CC, Wood MG, Que I, Van't Root M, Ridwan Y, Shi C, Kirkland TA, Encell LP, Wood KV, Löwik C, Mezzanotte L. Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging. Nat Commun. 2018 01 09; 9(1):132. PMID: 29317625.
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    15. Vasta JD, Corona CR, Wilkinson J, Zimprich CA, Hartnett JR, Ingold MR, Zimmerman K, Machleidt T, Kirkland TA, Huwiler KG, Ohana RF, Slater M, Otto P, Cong M, Wells CI, Berger BT, Hanke T, Glas C, Ding K, Drewry DH, Huber KVM, Willson TM, Knapp S, Müller S, Meisenheimer PL, Fan F, Wood KV, Robers MB. Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement. Cell Chem Biol. 2018 02 15; 25(2):206-214.e11. PMID: 29174542.
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    16. Shakhmin A, Hall MP, Machleidt T, Walker JR, Wood KV, Kirkland TA. Coelenterazine analogues emit red-shifted bioluminescence with NanoLuc. Org Biomol Chem. 2017 Oct 18; 15(40):8559-8567. PMID: 28972606.
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    17. Friedman Ohana R, Levin S, Wood MG, Zimmerman K, Dart ML, Schwinn MK, Kirkland TA, Hurst R, Uyeda HT, Encell LP, Wood KV. Improved Deconvolution of Protein Targets for Bioactive Compounds Using a Palladium Cleavable Chloroalkane Capture Tag. ACS Chem Biol. 2016 09 16; 11(9):2608-17. PMID: 27414062.
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    18. Shakhmin A, Hall MP, Walker JR, Machleidt T, Binkowski BF, Wood KV, Kirkland TA. Three Efficient Methods for Preparation of Coelenterazine Analogues. Chemistry. 2016 Jul 18; 22(30):10369-75. PMID: 27305599.
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    19. Dixon AS, Schwinn MK, Hall MP, Zimmerman K, Otto P, Lubben TH, Butler BL, Binkowski BF, Machleidt T, Kirkland TA, Wood MG, Eggers CT, Encell LP, Wood KV. NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells. ACS Chem Biol. 2016 Feb 19; 11(2):400-8. PMID: 26569370.
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    20. Robers MB, Dart ML, Woodroofe CC, Zimprich CA, Kirkland TA, Machleidt T, Kupcho KR, Levin S, Hartnett JR, Zimmerman K, Niles AL, Ohana RF, Daniels DL, Slater M, Wood MG, Cong M, Cheng YQ, Wood KV. Target engagement and drug residence time can be observed in living cells with BRET. Nat Commun. 2015 Dec 03; 6:10091. PMID: 26631872.
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    21. Ohana RF, Kirkland TA, Woodroofe CC, Levin S, Uyeda HT, Otto P, Hurst R, Robers MB, Zimmerman K, Encell LP, Wood KV. Deciphering the Cellular Targets of Bioactive Compounds Using a Chloroalkane Capture Tag. ACS Chem Biol. 2015 Oct 16; 10(10):2316-24. PMID: 26162280.
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    22. Machleidt T, Woodroofe CC, Schwinn MK, Méndez J, Robers MB, Zimmerman K, Otto P, Daniels DL, Kirkland TA, Wood KV. NanoBRET--A Novel BRET Platform for the Analysis of Protein-Protein Interactions. ACS Chem Biol. 2015 Aug 21; 10(8):1797-804. PMID: 26006698.
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    23. Halley F, Reinshagen J, Ellinger B, Wolf M, Niles AL, Evans NJ, Kirkland TA, Wagner JM, Jung M, Gribbon P, Gul S. A bioluminogenic HDAC activity assay: validation and screening. J Biomol Screen. 2011 Dec; 16(10):1227-35. PMID: 21832257.
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    24. Leippe DM, Nguyen D, Zhou M, Good T, Kirkland TA, Scurria M, Bernad L, Ugo T, Vidugiriene J, Cali JJ, Klaubert DH, O'Brien MA. A bioluminescent assay for the sensitive detection of proteases. Biotechniques. 2011 Aug; 51(2):105-10. PMID: 21806554.
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    25. Khim SK, Bauman J, Evans J, Freeman B, King B, Kirkland T, Kochanny M, Lentz D, Liang A, Mendoza L, Phillips G, Tseng JL, Wei RG, Ye H, Yu L, Parkinson J, Guilford WJ. Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):3895-8. PMID: 18590959.
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    26. Ye B, Bauman J, Chen M, Davey D, Khim SK, King B, Kirkland T, Kochanny M, Liang A, Lentz D, May K, Mendoza L, Phillips G, Selchau V, Schlyer S, Tseng JL, Wei RG, Ye H, Parkinson J, Guilford WJ. Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):3891-4. PMID: 18586492.
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    27. Möller C, Hoffmann J, Kirkland TA, Schwede W. Investigational developments for the treatment of progesterone-dependent diseases. Expert Opin Investig Drugs. 2008 Apr; 17(4):469-79. PMID: 18363513.
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    28. Kirkland TA, Adler M, Bauman JG, Chen M, Haeggström JZ, King B, Kochanny MJ, Liang AM, Mendoza L, Phillips GB, Thunnissen M, Trinh L, Whitlow M, Ye B, Ye H, Parkinson J, Guilford WJ. Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 01; 16(9):4963-83. PMID: 18394906.
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    29. Zajchowski DA, Biroc SL, Liu HL, Chesney SK, Hoffmann J, Bauman J, Kirkland T, Subramanyam B, Shen J, Ho E, Tseng JL, Dinter H. Anti-tumor efficacy of the nucleoside analog 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl) cytosine (4'-thio-FAC) in human pancreatic and ovarian tumor xenograft models. Int J Cancer. 2005 May 10; 114(6):1002-9. PMID: 15645422.
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    30. Kirkland TA, Grubbs RH. Effects of Olefin Substitution on the Ring-Closing Metathesis of Dienes. J Org Chem. 1997 Oct 17; 62(21):7310-7318. PMID: 11671845.
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    31. Kirkland TA, Lathem JE. The role of transrectal ultrasound (TRUS) in the evaluation of cancer of the prostate. J S C Med Assoc. 1994 May; 90(5):217-9. PMID: 8028292.
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    32. Scott AA, Stanley W, Worsham GF, Kirkland TA, Gansler T, Garvin AJ. Aggressive bladder carcinoma in an adolescent. Report of a case with immunohistochemical, cytogenetic, and flow cytometric characterization. Am J Surg Pathol. 1989 Dec; 13(12):1057-63. PMID: 2596618.
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