Thomas Clayton Jhou

Title
InstitutionMedical University of South Carolina
DepartmentNeuroscience
AddressP.O. Box MSC 510
DDB 203
70 President St.
Phone843-876-2290
Fax843-792-4423
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    Collapse Overview 
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    Major Research Areas: Our main focus is on brain pathways driving addiction, depression, and motivated behavior. We study these pathways and behaviors using electrophysiological, anatomical, and optogenetic methods.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Parrilla-Carrero J, Eid M, Li H, Chao YS, Jhou TC. Synaptic Adaptations at the Rostromedial Tegmental Nucleus Underlie Individual Differences in Cocaine Avoidance Behavior. J Neurosci. 2021 May 26; 41(21):4620-4630. PMID: 33753546.
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    2. Zhao YN, Yan YD, Wang CY, Qu WM, Jhou TC, Huang ZL, Yang SR. The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice. Nat Sci Sleep. 2020; 12:1215-1223. PMID: 33380853.
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    3. Cruz AM, Spencer HF, Kim TH, Jhou TC, Smith RJ. Prelimbic cortical projections to rostromedial tegmental nucleus play a suppressive role in cue-induced reinstatement of cocaine seeking. Neuropsychopharmacology. 2020 Nov 23. PMID: 33230269.
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    4. Li H, Eid M, Pullmann D, Chao YS, Thomas AA, Jhou TC. Entopeduncular Nucleus Projections to the Lateral Habenula Contribute to Cocaine Avoidance. J Neurosci. 2021 01 13; 41(2):298-306. PMID: 33214316.
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    5. Rodriguez-Romaguera J, Ung RL, Nomura H, Otis JM, Basiri ML, Namboodiri VMK, Zhu X, Robinson JE, van den Munkhof HE, McHenry JA, Eckman LEH, Kosyk O, Jhou TC, Kash TL, Bruchas MR, Stuber GD. Prepronociceptin-Expressing Neurons in the Extended Amygdala Encode and Promote Rapid Arousal Responses to Motivationally Salient Stimuli. Cell Rep. 2020 11 10; 33(6):108362. PMID: 33176134.
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    6. Vento PJ, Jhou TC. Bidirectional Valence Encoding in the Ventral Pallidum. Neuron. 2020 03 04; 105(5):766-768. PMID: 32135088.
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    7. Li H, Vento PJ, Parrilla-Carrero J, Pullmann D, Chao YS, Eid M, Jhou TC. Three Rostromedial Tegmental Afferents Drive Triply Dissociable Aspects of Punishment Learning and Aversive Valence Encoding. Neuron. 2019 12 04; 104(5):987-999.e4. PMID: 31627985.
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    8. Wright KM, Jhou TC, Pimpinelli D, McDannald MA. Cue-inhibited ventrolateral periaqueductal gray neurons signal fear output and threat probability in male rats. Elife. 2019 09 30; 8. PMID: 31566567.
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    9. Walker RA, Wright KM, Jhou TC, McDannald MA. The ventrolateral periaqueductal grey updates fear via positive prediction error. Eur J Neurosci. 2020 02; 51(3):866-880. PMID: 31376295.
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    10. Parker KE, Pedersen CE, Gomez AM, Spangler SM, Walicki MC, Feng SY, Stewart SL, Otis JM, Al-Hasani R, McCall JG, Sakers K, Bhatti DL, Copits BA, Gereau RW, Jhou T, Kash TJ, Dougherty JD, Stuber GD, Bruchas MR. A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward. Cell. 2019 07 25; 178(3):653-671.e19. PMID: 31348890.
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    11. Hardaway JA, Halladay LR, Mazzone CM, Pati D, Bloodgood DW, Kim M, Jensen J, DiBerto JF, Boyt KM, Shiddapur A, Erfani A, Hon OJ, Neira S, Stanhope CM, Sugam JA, Saddoris MP, Tipton G, McElligott Z, Jhou TC, Stuber GD, Bruchas MR, Bulik CM, Holmes A, Kash TL. Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward. Neuron. 2019 Jun 05; 102(5):1088. PMID: 31170393.
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    12. Glover EJ, Starr EM, Chao Y, Jhou TC, Chandler LJ. Inhibition of the rostromedial tegmental nucleus reverses alcohol withdrawal-induced anxiety-like behavior. Neuropsychopharmacology. 2019 10; 44(11):1896-1905. PMID: 31060041.
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    13. Hardaway JA, Halladay LR, Mazzone CM, Pati D, Bloodgood DW, Kim M, Jensen J, DiBerto JF, Boyt KM, Shiddapur A, Erfani A, Hon OJ, Neira S, Stanhope CM, Sugam JA, Saddoris MP, Tipton G, McElligott Z, Jhou TC, Stuber GD, Bruchas MR, Bulik CM, Holmes A, Kash TL. Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward. Neuron. 2019 06 05; 102(5):1037-1052.e7. PMID: 31029403.
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    14. Li H, Pullmann D, Jhou TC. Valence-encoding in the lateral habenula arises from the entopeduncular region. Elife. 2019 03 11; 8. PMID: 30855228.
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    15. Li H, Pullmann D, Cho JY, Eid M, Jhou TC. Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing. Elife. 2019 01 22; 8. PMID: 30667358.
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    16. Smith RJ, Vento PJ, Chao YS, Good CH, Jhou TC. Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and mice. Brain Struct Funct. 2019 Jan; 224(1):219-238. PMID: 30302539.
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    17. Baker PM, Jhou T, Li B, Matsumoto M, Mizumori SJ, Stephenson-Jones M, Vicentic A. The Lateral Habenula Circuitry: Reward Processing and Cognitive Control. J Neurosci. 2016 11 09; 36(45):11482-11488. PMID: 27911751.
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    18. Vento PJ, Burnham NW, Rowley CS, Jhou TC. Learning From One's Mistakes: A Dual Role for the Rostromedial Tegmental Nucleus in the Encoding and Expression of Punished Reward Seeking. Biol Psychiatry. 2017 06 15; 81(12):1041-1049. PMID: 27931744.
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    19. Glover EJ, McDougle MJ, Siegel GS, Jhou TC, Chandler LJ. Role for the Rostromedial Tegmental Nucleus in Signaling the Aversive Properties of Alcohol. Alcohol Clin Exp Res. 2016 08; 40(8):1651-61. PMID: 27388762.
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    20. Brown RM, Kupchik YM, Spencer S, Garcia-Keller C, Spanswick DC, Lawrence AJ, Simonds SE, Schwartz DJ, Jordan KA, Jhou TC, Kalivas PW. Addiction-like Synaptic Impairments in Diet-Induced Obesity. Biol Psychiatry. 2017 05 01; 81(9):797-806. PMID: 26826876.
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    21. Vujovic N, Gooley JJ, Jhou TC, Saper CB. Projections from the subparaventricular zone define four channels of output from the circadian timing system. J Comp Neurol. 2015 Dec 15; 523(18):2714-37. PMID: 26010698.
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    22. Quina LA, Tempest L, Ng L, Harris JA, Ferguson S, Jhou TC, Turner EE. Efferent pathways of the mouse lateral habenula. J Comp Neurol. 2015 Jan 01; 523(1):32-60. PMID: 25099741.
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    23. Bentzley BS, Jhou TC, Aston-Jones G. Economic demand predicts addiction-like behavior and therapeutic efficacy of oxytocin in the rat. Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):11822-7. PMID: 25071176.
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    24. Jhou TC, Good CH, Rowley CS, Xu SP, Wang H, Burnham NW, Hoffman AF, Lupica CR, Ikemoto S. Cocaine drives aversive conditioning via delayed activation of dopamine-responsive habenular and midbrain pathways. J Neurosci. 2013 Apr 24; 33(17):7501-12. PMID: 23616555.
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    25. Barrot M, Sesack SR, Georges F, Pistis M, Hong S, Jhou TC. Braking dopamine systems: a new GABA master structure for mesolimbic and nigrostriatal functions. J Neurosci. 2012 Oct 10; 32(41):14094-101. PMID: 23055478.
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    26. Webb SM, Vollrath-Smith FR, Shin R, Jhou TC, Xu S, Ikemoto S. Rewarding and incentive motivational effects of excitatory amino acid receptor antagonists into the median raphe and adjacent regions of the rat. Psychopharmacology (Berl). 2012 Dec; 224(3):401-12. PMID: 22752328.
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    27. Jhou TC, Xu SP, Lee MR, Gallen CL, Ikemoto S. Mapping of reinforcing and analgesic effects of the mu opioid agonist endomorphin-1 in the ventral midbrain of the rat. Psychopharmacology (Berl). 2012 Nov; 224(2):303-12. PMID: 22669129.
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    28. Hong S, Jhou TC, Smith M, Saleem KS, Hikosaka O. Negative reward signals from the lateral habenula to dopamine neurons are mediated by rostromedial tegmental nucleus in primates. J Neurosci. 2011 Aug 10; 31(32):11457-71. PMID: 21832176.
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    29. Jhou TC, Geisler S, Marinelli M, Degarmo BA, Zahm DS. The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta. J Comp Neurol. 2009 Apr 20; 513(6):566-96. PMID: 19235216.
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    30. Jhou TC, Fields HL, Baxter MG, Saper CB, Holland PC. The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron. 2009 Mar 12; 61(5):786-800. PMID: 19285474.
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    31. Greco MA, Fuller PM, Jhou TC, Martin-Schild S, Zadina JE, Hu Z, Shiromani P, Lu J. Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus. Brain Res. 2008 Dec 15; 1245:96-107. PMID: 18840417.
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    32. Phillips PE, Walton ME, Jhou TC. Calculating utility: preclinical evidence for cost-benefit analysis by mesolimbic dopamine. Psychopharmacology (Berl). 2007 Apr; 191(3):483-95. PMID: 17119929.
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    33. Lu J, Jhou TC, Saper CB. Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter. J Neurosci. 2006 Jan 04; 26(1):193-202. PMID: 16399687.
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    34. Jhou T. Neural mechanisms of freezing and passive aversive behaviors. J Comp Neurol. 2005 Dec 05; 493(1):111-4. PMID: 16254996.
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    35. Chou TC, Rotman SR, Saper CB. Lateral hypothalamic acetylcholinesterase-immunoreactive neurons co-express either orexin or melanin concentrating hormone. Neurosci Lett. 2004 Nov 11; 370(2-3):123-6. PMID: 15488307.
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    36. Gerashchenko D, Chou TC, Blanco-Centurion CA, Saper CB, Shiromani PJ. Effects of lesions of the histaminergic tuberomammillary nucleus on spontaneous sleep in rats. Sleep. 2004 Nov 01; 27(7):1275-81. PMID: 15586780.
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    37. Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J. Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J Neurosci. 2003 Nov 19; 23(33):10691-702. PMID: 14627654.
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    38. Chamberlin NL, Arrigoni E, Chou TC, Scammell TE, Greene RW, Saper CB. Effects of adenosine on gabaergic synaptic inputs to identified ventrolateral preoptic neurons. Neuroscience. 2003; 119(4):913-8. PMID: 12831851.
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    39. Saper CB, Chou TC, Elmquist JK. The need to feed: homeostatic and hedonic control of eating. Neuron. 2002 Oct 10; 36(2):199-211. PMID: 12383777.
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    40. Chou TC, Bjorkum AA, Gaus SE, Lu J, Scammell TE, Saper CB. Afferents to the ventrolateral preoptic nucleus. J Neurosci. 2002 Feb 01; 22(3):977-90. PMID: 11826126.
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    41. Gooley JJ, Lu J, Chou TC, Scammell TE, Saper CB. Melanopsin in cells of origin of the retinohypothalamic tract. Nat Neurosci. 2001 Dec; 4(12):1165. PMID: 11713469.
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    42. Saper CB, Chou TC, Scammell TE. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 2001 Dec; 24(12):726-31. PMID: 11718878.
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    43. Chou TC, Lee CE, Lu J, Elmquist JK, Hara J, Willie JT, Beuckmann CT, Chemelli RM, Sakurai T, Yanagisawa M, Saper CB, Scammell TE. Orexin (hypocretin) neurons contain dynorphin. J Neurosci. 2001 Oct 01; 21(19):RC168. PMID: 11567079.
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    44. Lu J, Zhang YH, Chou TC, Gaus SE, Elmquist JK, Shiromani P, Saper CB. Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation. J Neurosci. 2001 Jul 01; 21(13):4864-74. PMID: 11425913.
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    45. Estabrooke IV, McCarthy MT, Ko E, Chou TC, Chemelli RM, Yanagisawa M, Saper CB, Scammell TE. Fos expression in orexin neurons varies with behavioral state. J Neurosci. 2001 Mar 01; 21(5):1656-62. PMID: 11222656.
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