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Thomas A. Dix

Title
InstitutionMedical University of South Carolina
DepartmentCOP Drug Discovery and Biomedical Sciences - MUSC Campus
AddressP.O. Box MSC140
DDB414
Drug Discovery Building - 70 President St.
Phone843-876-5092
Fax843-792-1617
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhong W, Yuan Y, Gu X, Kim SI, Chin R, Loye M, Dix TA, Wei L, Yu SP. Neuropsychological Deficits Chronically Developed after Focal Ischemic Stroke and Beneficial Effects of Pharmacological Hypothermia in the Mouse. Aging Dis. 2020 Feb; 11(1):1-16. PMID: 32010477.
      View in: PubMed
    2. Zhao Y, Wei ZZ, Lee JH, Gu X, Sun J, Dix TA, Wei L, Yu SP. Pharmacological hypothermia induced neurovascular protection after severe stroke of transient middle cerebral artery occlusion in mice. Exp Neurol. 2020 Mar; 325:113133. PMID: 31770520.
      View in: PubMed
    3. Beck TC, Dix TA. Targeting peripheral ?-opioid receptors for the non-addictive treatment of pain. Future Drug Discov. 2019 Oct; 1(2). PMID: 31742251.
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    4. Beck TC, Hapstack MA, Ghatnekar GS, Dix TA. Diuretic Activity of a Novel Peripherally-Restricted Orally-Active Kappa Opioid Receptor Agonist. Med Sci (Basel). 2019 Aug 31; 7(9). PMID: 31480425.
      View in: PubMed
    5. Beck TC, Hapstack MA, Beck KR, Dix TA. Therapeutic Potential of Kappa Opioid Agonists. Pharmaceuticals (Basel). 2019 Jun 20; 12(2). PMID: 31226764.
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    6. Beck TC, Reichel CM, Helke KL, Bhadsavle SS, Dix TA. Non-addictive orally-active kappa opioid agonists for the treatment of peripheral pain in rats. Eur J Pharmacol. 2019 Aug 05; 856:172396. PMID: 31103632.
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    7. Li H, Hua T, Wang W, Wu X, Miao C, Huang W, Xiao Y, Yang J, Bradley JL, Peberdy MA, Ornato J, Dix TA, Beck T, Tang W. The Effects of Pharmacological Hypothermia Induced by Neurotensin Receptor Agonist ABS 201 on Outcomes of CPR. Shock. 2019 05; 51(5):667-673. PMID: 30986796.
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    8. Wang S, Gu X, Paudyal R, Wei L, Dix TA, Yu SP, Zhang X. Longitudinal MRI evaluation of neuroprotective effects of pharmacologically induced hypothermia in experimental ischemic stroke. Magn Reson Imaging. 2017 07; 40:24-30. PMID: 28377304.
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    9. Devader C, Moreno S, Roulot M, Deval E, Dix T, Morales CR, Mazella J. Increased Brain Neurotensin and NTSR2 Lead to Weak Nociception in NTSR3/Sortilin Knockout Mice. Front Neurosci. 2016; 10:542. PMID: 27932946.
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    10. Lee JH, Wei ZZ, Cao W, Won S, Gu X, Winter M, Dix TA, Wei L, Yu SP. Regulation of therapeutic hypothermia on inflammatory cytokines, microglia polarization, migration and functional recovery after ischemic stroke in mice. Neurobiol Dis. 2016 Dec; 96:248-260. PMID: 27659107.
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    11. Lee JH, Wei L, Gu X, Won S, Wei ZZ, Dix TA, Yu SP. Improved Therapeutic Benefits by Combining Physical Cooling With Pharmacological Hypothermia After Severe Stroke in Rats. Stroke. 2016 07; 47(7):1907-13. PMID: 27301934.
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    12. Gu X, Wei ZZ, Espinera A, Lee JH, Ji X, Wei L, Dix TA, Yu SP. Pharmacologically induced hypothermia attenuates traumatic brain injury in neonatal rats. Exp Neurol. 2015 May; 267:135-142. PMID: 25725354.
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    13. Lee JH, Wei L, Gu X, Wei Z, Dix TA, Yu SP. Therapeutic effects of pharmacologically induced hypothermia against traumatic brain injury in mice. J Neurotrauma. 2014 Aug 15; 31(16):1417-30. PMID: 24731132.
      View in: PubMed
    14. Hughes FM, Shaner BE, Brower JO, Woods RJ, Dix TA. Development of a Peptide-derived orally-active kappa-opioid receptor agonist targeting peripheral pain. Open Med Chem J. 2013; 7:16-22. PMID: 24222801.
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    15. Sauls K, de Vlaming A, Harris BS, Williams K, Wessels A, Levine RA, Slaugenhaupt SA, Goodwin RL, Pavone LM, Merot J, Schott JJ, Le Tourneau T, Dix T, Jesinkey S, Feng Y, Walsh C, Zhou B, Baldwin S, Markwald RR, Norris RA. Developmental basis for filamin-A-associated myxomatous mitral valve disease. Cardiovasc Res. 2012 Oct 01; 96(1):109-19. PMID: 22843703.
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    16. Choi KE, Hall CL, Sun JM, Wei L, Mohamad O, Dix TA, Yu SP. A novel stroke therapy of pharmacologically induced hypothermia after focal cerebral ischemia in mice. FASEB J. 2012 Jul; 26(7):2799-810. PMID: 22459147.
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    17. Hughes FM, Shaner BE, May LA, Zotian L, Brower JO, Woods RJ, Cash M, Morrow D, Massa F, Mazella J, Dix TA. Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesic. J Med Chem. 2010 Jun 24; 53(12):4623-32. PMID: 20481538.
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    18. Orwig KS, Lassetter MR, Hadden MK, Dix TA. Comparison of N-terminal modifications on neurotensin(8-13) analogues correlates peptide stability but not binding affinity with in vivo efficacy. J Med Chem. 2009 Apr 09; 52(7):1803-13. PMID: 19290594.
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    19. Hadden MK, Orwig KS, Kokko KP, Mazella J, Dix TA. Design, synthesis, and evaluation of the antipsychotic potential of orally bioavailable neurotensin (8-13) analogues containing non-natural arginine and lysine residues. Neuropharmacology. 2005 Dec; 49(8):1149-59. PMID: 16095636.
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    20. Kokko KP, Hadden MK, Price KL, Orwig KS, See RE, Dix TA. In vivo behavioral effects of stable, receptor-selective neurotensin[8-13] analogues that cross the blood-brain barrier. Neuropharmacology. 2005 Mar; 48(3):417-25. PMID: 15721174.
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    21. Hadden MK, Walle T, Dix TA. Cellular uptake of a radiolabelled analogue of neurotensin in the Caco-2 cell model. J Pharm Pharmacol. 2005 Mar; 57(3):327-33. PMID: 15807988.
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    22. May LA, Tourkina E, Hoffman SR, Dix TA. Detection and quantitation of curcumin in mouse lung cell cultures by matrix-assisted laser desorption ionization time of flight mass spectrometry. Anal Biochem. 2005 Feb 01; 337(1):62-9. PMID: 15649376.
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    23. Kokko KP, Hadden MK, Orwig KS, Mazella J, Dix TA. In vitro analysis of stable, receptor-selective neurotensin[8-13] analogues. J Med Chem. 2003 Sep 11; 46(19):4141-8. PMID: 12954066.
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    24. Kokko KP, Dix TA. Monitoring neurotensin[8-13] degradation in human and rat serum utilizing matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Biochem. 2002 Sep 01; 308(1):34-41. PMID: 12234461.
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