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Steven W Kubalak

Title
InstitutionMedical University of South Carolina
DepartmentRegenerative Medicine and Cell Biology
AddressP.O. Box MSC 508
BSB 615C
Basic Science Building - 173 Ashley Ave.
Phone843-792-0624
Fax843-792-0664
ORCID ORCID Icon0000-0002-5557-2781 Additional info
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    Collapse Biography 
    Collapse education and training
    University of Wisconsin Green Bay, Green Bay, WIBS1985Biology
    Medical University of South Carolina, Charleston , SCPhD1991Pharmacology
    Medical University of South Carolina, Charleston, SC1992Pharmacology
    University of California San Diego, San Diego, CA1996Cardiac Development

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ross GA, Ashenburg NG, Wynn WD, McCarthy JJ, Clendening AM, Presley BC, Kubalak SW, Barnes RM. Intra-Articular Catheter Placement: A Novel Approach for Simulating Ankle Effusions in Cadaver Models. West J Emerg Med. 2019 01; 20(1):92-93. PMID: 30643607.
      View in: PubMed
    2. Robichaux JP, Fuseler JW, Patel SS, Kubalak SW, Hartstone-Rose A, Ramsdell AF. Left-right analysis of mammary gland development in retinoid X receptor-a+/- mice. Philos Trans R Soc Lond B Biol Sci. 2016 12 19; 371(1710). PMID: 27821527.
      View in: PubMed
    3. Hoover LL, Kubalak SW. Holding their own: the noncanonical roles of Smad proteins. Sci Signal. 2008 Nov 18; 1(46):pe48. PMID: 19018011.
      View in: PubMed
    4. Hoover LL, Burton EG, O'Neill ML, Brooks BA, Sreedharan S, Dawson NA, Kubalak SW. Retinoids regulate TGFbeta signaling at the level of Smad2 phosphorylation and nuclear accumulation. Biochim Biophys Acta. 2008 Dec; 1783(12):2279-86. PMID: 18773928.
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    5. Hoover LL, Burton EG, Brooks BA, Kubalak SW. The expanding role for retinoid signaling in heart development. ScientificWorldJournal. 2008 Feb 25; 8:194-211. PMID: 18661045.
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    6. Snarr BS, O'Neal JL, Chintalapudi MR, Wirrig EE, Phelps AL, Kubalak SW, Wessels A. Isl1 expression at the venous pole identifies a novel role for the second heart field in cardiac development. Circ Res. 2007 Nov 09; 101(10):971-4. PMID: 17947796.
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    7. Menick DR, Renaud L, Buchholz A, Müller JG, Zhou H, Kappler CS, Kubalak SW, Conway SJ, Xu L. Regulation of Ncx1 gene expression in the normal and hypertrophic heart. Ann N Y Acad Sci. 2007 Mar; 1099:195-203. PMID: 17446459.
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    8. Xu L, Renaud L, Müller JG, Baicu CF, Bonnema DD, Zhou H, Kappler CS, Kubalak SW, Zile MR, Conway SJ, Menick DR. Regulation of Ncx1 expression. Identification of regulatory elements mediating cardiac-specific expression and up-regulation. J Biol Chem. 2006 Nov 10; 281(45):34430-40. PMID: 16966329.
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    9. Merki E, Zamora M, Raya A, Kawakami Y, Wang J, Zhang X, Burch J, Kubalak SW, Kaliman P, Izpisua Belmonte JC, Chien KR, Ruiz-Lozano P. Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18455-60. PMID: 16352730.
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    10. Hewett KW, Norman LW, Sedmera D, Barker RJ, Justus C, Zhang J, Kubalak SW, Gourdie RG. Knockout of the neural and heart expressed gene HF-1b results in apical deficits of ventricular structure and activation. Cardiovasc Res. 2005 Aug 15; 67(3):548-60. PMID: 15907824.
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    11. Jenkins SJ, Hutson DR, Kubalak SW. Analysis of the proepicardium-epicardium transition during the malformation of the RXRalpha-/- epicardium. Dev Dyn. 2005 Jul; 233(3):1091-101. PMID: 15861408.
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    12. Eisenberg LM, Kubalak SW, Eisenberg CA. Stem cells and the formation of the myocardium in the vertebrate embryo. Anat Rec A Discov Mol Cell Evol Biol. 2004 Jan; 276(1):2-12. PMID: 14699629.
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    13. Sedmera D, Reckova M, DeAlmeida A, Coppen SR, Kubalak SW, Gourdie RG, Thompson RP. Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system. Anat Rec A Discov Mol Cell Evol Biol. 2003 Sep; 274(1):773-7. PMID: 12923887.
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    14. Kubalak SW, Hutson DR, Scott KK, Shannon RA. Elevated transforming growth factor beta2 enhances apoptosis and contributes to abnormal outflow tract and aortic sac development in retinoic X receptor alpha knockout embryos. Development. 2002 Feb; 129(3):733-46. PMID: 11830573.
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    15. Pashmforoush M, Pomiès P, Peterson KL, Kubalak S, Ross J, Hefti A, Aebi U, Beckerle MC, Chien KR. Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nat Med. 2001 May; 7(5):591-7. PMID: 11329061.
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    16. Nguyên-Trân VT, Kubalak SW, Minamisawa S, Fiset C, Wollert KC, Brown AB, Ruiz-Lozano P, Barrere-Lemaire S, Kondo R, Norman LW, Gourdie RG, Rahme MM, Feld GK, Clark RB, Giles WR, Chien KR. A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages. Cell. 2000 Sep 01; 102(5):671-82. PMID: 11007485.
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    17. Camenisch TD, Spicer AP, Brehm-Gibson T, Biesterfeldt J, Augustine ML, Calabro A, Kubalak S, Klewer SE, McDonald JA. Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. J Clin Invest. 2000 Aug; 106(3):349-60. PMID: 10930438.
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    18. Doevendans PA, Kubalak SW, An RH, Becker DK, Chien KR, Kass RS. Differentiation of cardiomyocytes in floating embryoid bodies is comparable to fetal cardiomyocytes. J Mol Cell Cardiol. 2000 May; 32(5):839-51. PMID: 10775488.
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    19. Doevendans PA, Bronsaer R, Lozano PR, Kubalak S, van Bilsen M. The murine atrial myosin light chain-2 gene: a member of an evolutionarily conserved family of contractile proteins. Cytogenet Cell Genet. 2000; 90(3-4):248-52. PMID: 11124527.
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    20. Hertig CM, Kubalak SW, Wang Y, Chien KR. Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the phosphatidylinositol 3-kinase pathway and cardiac chamber morphogenesis. J Biol Chem. 1999 Dec 24; 274(52):37362-9. PMID: 10601306.
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    21. Gourdie RG, Kubalak S, Mikawa T. Conducting the embryonic heart: orchestrating development of specialized cardiac tissues. Trends Cardiovasc Med. 1999 Jan-Feb; 9(1-2):18-26. PMID: 10189963.
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    22. Gruber PJ, Kubalak SW, Chien KR. Downregulation of atrial markers during cardiac chamber morphogenesis is irreversible in murine embryos. Development. 1998 Nov; 125(22):4427-38. PMID: 9778502.
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    23. Chen J, Kubalak SW, Chien KR. Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis. Development. 1998 May; 125(10):1943-9. PMID: 9550726.
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    24. Ruiz-Lozano P, Smith SM, Perkins G, Kubalak SW, Boss GR, Sucov HM, Evans RM, Chien KR. Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRalpha-/- embryos. Development. 1998 Feb; 125(3):533-44. PMID: 9425147.
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    25. Chen J, Kubalak SW, Minamisawa S, Price RL, Becker KD, Hickey R, Ross J, Chien KR. Selective requirement of myosin light chain 2v in embryonic heart function. J Biol Chem. 1998 Jan 09; 273(2):1252-6. PMID: 9422794.
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    26. Zhang J, Sato M, Duzic E, Kubalak SW, Lanier SM, Webb JG. Adenylyl cyclase isoforms and vasopressin enhancement of agonist-stimulated cAMP in vascular smooth muscle cells. Am J Physiol. 1997 Aug; 273(2 Pt 2):H971-80. PMID: 9277517.
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    27. Gruber PJ, Kubalak SW, Pexieder T, Sucov HM, Evans RM, Chien KR. RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice. J Clin Invest. 1996 Sep 15; 98(6):1332-43. PMID: 8823298.
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    28. An RH, Davies MP, Doevendans PA, Kubalak SW, Bangalore R, Chien KR, Kass RS. Developmental changes in beta-adrenergic modulation of L-type Ca2+ channels in embryonic mouse heart. Circ Res. 1996 Mar; 78(3):371-8. PMID: 8593695.
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    29. Sucov HM, Lou J, Gruber PJ, Kubalak SW, Dyson E, Gumeringer CL, Lee RY, Moles SA, Chien KR, Giguere V, Evans RM. The molecular genetics of retinoic acid receptors: cardiovascular and limb development. Biochem Soc Symp. 1996; 62:143-56. PMID: 8971347.
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    30. Davies MP, An RH, Doevendans P, Kubalak S, Chien KR, Kass RS. Developmental changes in ionic channel activity in the embryonic murine heart. Circ Res. 1996 Jan; 78(1):15-25. PMID: 8603498.
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    31. Dyson E, Sucov HM, Kubalak SW, Schmid-Schönbein GW, DeLano FA, Evans RM, Ross J, Chien KR. Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice. Proc Natl Acad Sci U S A. 1995 Aug 01; 92(16):7386-90. PMID: 7638202.
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    32. Kubalak SW, Miller-Hance WC, O'Brien TX, Dyson E, Chien KR. Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. J Biol Chem. 1994 Jun 17; 269(24):16961-70. PMID: 8207020.
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    33. Hunter JJ, Zhu H, Lee KJ, Kubalak S, Chien KR. Targeting gene expression to specific cardiovascular cell types in transgenic mice. Hypertension. 1993 Oct; 22(4):608-17. PMID: 8406667.
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    34. Kubalak SW, Webb JG. Angiotensin II enhancement of hormone-stimulated cAMP formation in cultured vascular smooth muscle cells. Am J Physiol. 1993 Jan; 264(1 Pt 2):H86-96. PMID: 8381612.
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    35. Kubalak SW, Newman WH, Webb JG. Differential effect of pertussis toxin on adenosine and muscarinic inhibition of cyclic AMP accumulation in canine ventricular myocytes. J Mol Cell Cardiol. 1991 Feb; 23(2):199-205. PMID: 1648626.
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    36. Oehlenschlager WF, Kubalak SW, Currie MG. A rapid and economical method of preparing radioiodinated cyclic nucleotide derivatives for use in radioimmunoassays. J Immunoassay. 1990; 11(1):109-18. PMID: 2159027.
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