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Institution

Rosalie K. Crouch

Title
InstitutionMedical University of South Carolina
DepartmentOphthalmology
AddressP.O. Box MSC 676
711
167 Ashley Ave.
Phone843-792-2814
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    Collapse Biography 
    Collapse awards and honors
    2013SC Governor's Award for Excellence in Science
    2008Research Award, American Society for Photobiology
    2010ARVO Fellow, Association for Research in Vision and Ophthalmolgy

    Collapse Overview 
    Collapse overview
    Our group is studying the mechanisms responsible for, as well as possible therapeutic approaches to preventing and/or treating, various blinding diseases, particularly retina degenerations and AMD.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Anderson DMG, Ablonczy Z, Koutalos Y, Hanneken AM, Spraggins JM, Calcutt MW, Crouch RK, Caprioli RM, Schey KL. Bis(monoacylglycero)phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas. Sci Rep. 2017 12 11; 7(1):17352. PMID: 29229934.
      View in: PubMed
    2. Sheridan C, Boyer NP, Crouch RK, Koutalos Y. RPE65 and the Accumulation of Retinyl Esters in Mouse Retinal Pigment Epithelium. Photochem Photobiol. 2017 05; 93(3):844-848. PMID: 28500718.
      View in: PubMed
    3. Anderson DMG, Lambert W, Calkins DJ, Ablonczy Z, Crouch RK, Caprioli RM, Schey KL. Imaging MS of Rodent Ocular Tissues and the Optic Nerve. Methods Mol Biol. 2017; 1618:15-27. PMID: 28523496.
      View in: PubMed
    4. Bowrey HE, Anderson DM, Pallitto P, Gutierrez DB, Fan J, Crouch RK, Schey KL, Ablonczy Z. Imaging mass spectrometry of the visual system: Advancing the molecular understanding of retina degenerations. Proteomics Clin Appl. 2016 Apr; 10(4):391-402. PMID: 26586164.
      View in: PubMed
    5. Adler L, Boyer NP, Anderson DM, Spraggins JM, Schey KL, Hanneken A, Ablonczy Z, Crouch RK, Koutalos Y. Determination of N-retinylidene-N-retinylethanolamine (A2E) levels in central and peripheral areas of human retinal pigment epithelium. Photochem Photobiol Sci. 2015 Nov; 14(11):1983-90. PMID: 26323192.
      View in: PubMed
    6. Pallitto P, Ablonczy Z, Jones EE, Drake RR, Koutalos Y, Crouch RK, Donello J, Herrmann J. A2E and lipofuscin distributions in macaque retinal pigment epithelium are similar to human. Photochem Photobiol Sci. 2015 Oct; 14(10):1888-95. PMID: 26223373.
      View in: PubMed
    7. Crouch RK, Koutalos Y, Kono M, Schey K, Ablonczy Z. A2E and Lipofuscin. Prog Mol Biol Transl Sci. 2015; 134:449-63. PMID: 26310170.
      View in: PubMed
    8. Adler L, Boyer NP, Chen C, Ablonczy Z, Crouch RK, Koutalos Y. The 11-cis Retinal Origins of Lipofuscin in the Retina. Prog Mol Biol Transl Sci. 2015; 134:e1-12. PMID: 26310175.
      View in: PubMed
    9. Tang PH, Crouch RK. Sustained delivery of retinoids to prevent photoreceptor death. Methods Mol Biol. 2015; 1271:363-8. PMID: 25697535.
      View in: PubMed
    10. Isayama T, Chen Y, Kono M, Fabre E, Slavsky M, DeGrip WJ, Ma JX, Crouch RK, Makino CL. Coexpression of three opsins in cone photoreceptors of the salamander Ambystoma tigrinum. J Comp Neurol. 2014 Jul 01; 522(10):2249-65. PMID: 24374736.
      View in: PubMed
    11. Anderson DM, Ablonczy Z, Koutalos Y, Spraggins J, Crouch RK, Caprioli RM, Schey KL. High resolution MALDI imaging mass spectrometry of retinal tissue lipids. J Am Soc Mass Spectrom. 2014 Aug; 25(8):1394-403. PMID: 24819461.
      View in: PubMed
    12. Crouch RK, Kono M. Ligand control of g protein-coupled receptor activity: new insights. Chem Biol. 2014 Mar 20; 21(3):309-10. PMID: 24655920.
      View in: PubMed
    13. Ablonczy Z, Smith N, Anderson DM, Grey AC, Spraggins J, Koutalos Y, Schey KL, Crouch RK. The utilization of fluorescence to identify the components of lipofuscin by imaging mass spectrometry. Proteomics. 2014 Apr; 14(7-8):936-44. PMID: 24453194.
      View in: PubMed
    14. Ablonczy Z, Higbee D, Grey AC, Koutalos Y, Schey KL, Crouch RK. Similar molecules spatially correlate with lipofuscin and N-retinylidene-N-retinylethanolamine in the mouse but not in the human retinal pigment epithelium. Arch Biochem Biophys. 2013 Nov 15; 539(2):196-202. PMID: 23969078.
      View in: PubMed
    15. Ablonczy Z, Higbee D, Anderson DM, Dahrouj M, Grey AC, Gutierrez D, Koutalos Y, Schey KL, Hanneken A, Crouch RK. Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2013 Aug 15; 54(8):5535-42. PMID: 23847313.
      View in: PubMed
    16. Tang PH, Kono M, Koutalos Y, Ablonczy Z, Crouch RK. New insights into retinoid metabolism and cycling within the retina. Prog Retin Eye Res. 2013 Jan; 32:48-63. PMID: 23063666.
      View in: PubMed
    17. Frederiksen R, Boyer NP, Nickle B, Chakrabarti KS, Koutalos Y, Crouch RK, Oprian D, Cornwall MC. Low aqueous solubility of 11-cis-retinal limits the rate of pigment formation and dark adaptation in salamander rods. J Gen Physiol. 2012 Jun; 139(6):493-505. PMID: 22641642.
      View in: PubMed
    18. Boyer NP, Higbee D, Currin MB, Blakeley LR, Chen C, Ablonczy Z, Crouch RK, Koutalos Y. Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in retinal pigment epithelium in absence of light exposure: their origin is 11-cis-retinal. J Biol Chem. 2012 Jun 22; 287(26):22276-86. PMID: 22570475.
      View in: PubMed
    19. Boyer NP, Tang PH, Higbee D, Ablonczy Z, Crouch RK, Koutalos Y. Lipofuscin and A2E accumulate with age in the retinal pigment epithelium of Nrl-/- mice. Photochem Photobiol. 2012 Nov-Dec; 88(6):1373-7. PMID: 22417141.
      View in: PubMed
    20. Ablonczy Z, Gutierrez DB, Grey AC, Schey KL, Crouch RK. Molecule-specific imaging and quantitation of A2E in the RPE. Adv Exp Med Biol. 2012; 723:75-81. PMID: 22183318.
      View in: PubMed
    21. Tang PH, Buhusi MC, Ma JX, Crouch RK. RPE65 is present in human green/red cones and promotes photopigment regeneration in an in vitro cone cell model. J Neurosci. 2011 Dec 14; 31(50):18618-26. PMID: 22171060.
      View in: PubMed
    22. Tang PH, Wheless L, Crouch RK. Regeneration of photopigment is enhanced in mouse cone photoreceptors expressing RPE65 protein. J Neurosci. 2011 Jul 13; 31(28):10403-11. PMID: 21753017.
      View in: PubMed
    23. Grey AC, Crouch RK, Koutalos Y, Schey KL, Ablonczy Z. Spatial localization of A2E in the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2011 Jun 06; 52(7):3926-33. PMID: 21357388.
      View in: PubMed
    24. Blakeley LR, Chen C, Chen CK, Chen J, Crouch RK, Travis GH, Koutalos Y. Rod outer segment retinol formation is independent of Abca4, arrestin, rhodopsin kinase, and rhodopsin palmitylation. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3483-91. PMID: 21398289.
      View in: PubMed
    25. Kolesnikov AV, Tang PH, Parker RO, Crouch RK, Kefalov VJ. The mammalian cone visual cycle promotes rapid M/L-cone pigment regeneration independently of the interphotoreceptor retinoid-binding protein. J Neurosci. 2011 May 25; 31(21):7900-9. PMID: 21613504.
      View in: PubMed
    26. Fan J, Crouch RK, Kono M. Light prevents exogenous 11-cis retinal from maintaining cone photoreceptors in chromophore-deficient mice. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2412-6. PMID: 21228385.
      View in: PubMed
    27. Parker R, Wang JS, Kefalov VJ, Crouch RK. Interphotoreceptor retinoid-binding protein as the physiologically relevant carrier of 11-cis-retinol in the cone visual cycle. J Neurosci. 2011 Mar 23; 31(12):4714-9. PMID: 21430170.
      View in: PubMed
    28. Kono M, Crouch RK. Probing human red cone opsin activity with retinal analogues. J Nat Prod. 2011 Mar 25; 74(3):391-4. PMID: 21314100.
      View in: PubMed
    29. Gutierrez DB, Blakeley L, Goletz PW, Schey KL, Hanneken A, Koutalos Y, Crouch RK, Ablonczy Z. Mass spectrometry provides accurate and sensitive quantitation of A2E. Photochem Photobiol Sci. 2010 Nov; 9(11):1513-9. PMID: 20931136.
      View in: PubMed
    30. Makino CL, Riley CK, Looney J, Crouch RK, Okada T. Binding of more than one retinoid to visual opsins. Biophys J. 2010 Oct 06; 99(7):2366-73. PMID: 20923672.
      View in: PubMed
    31. Parker RO, Crouch RK. Retinol dehydrogenases (RDHs) in the visual cycle. Exp Eye Res. 2010 Dec; 91(6):788-92. PMID: 20801113.
      View in: PubMed
    32. Kolesnikov AV, Fan J, Crouch RK, Kefalov VJ. Age-related deterioration of rod vision in mice. J Neurosci. 2010 Aug 18; 30(33):11222-31. PMID: 20720130.
      View in: PubMed
    33. Tang PH, Fan J, Goletz PW, Wheless L, Crouch RK. Effective and sustained delivery of hydrophobic retinoids to photoreceptors. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5958-64. PMID: 20574023.
      View in: PubMed
    34. Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K. Palmitoylation stabilizes unliganded rod opsin. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8428-33. PMID: 20404157.
      View in: PubMed
    35. Best CL, Smith DW, Raymond JR, Greenberg RS, Crouch RK. Preventing and responding to complaints of sexual harassment in an academic health center: a 10-year review from the Medical University of South Carolina. Acad Med. 2010 Apr; 85(4):721-7. PMID: 20354396.
      View in: PubMed
    36. Parker RO, Mccarragher B, Crouch R, Darden AG. Photoreceptor development in premetamorphic and metamorphic Xenopus laevis. Anat Rec (Hoboken). 2010 Mar; 293(3):383-7. PMID: 20091886.
      View in: PubMed
    37. Fan J, Sakurai K, Chen CK, Rohrer B, Wu BX, Yau KW, Kefalov V, Crouch RK. Deletion of GRK1 causes retina degeneration through a transducin-independent mechanism. J Neurosci. 2010 Feb 17; 30(7):2496-503. PMID: 20164334.
      View in: PubMed
    38. Parker RO, Crouch RK. The interphotoreceptor retinoid binding (IRBP) is essential for normal retinoid processing in cone photoreceptors. Adv Exp Med Biol. 2010; 664:141-9. PMID: 20238012.
      View in: PubMed
    39. Kono M, Crouch RK. In vitro assays of rod and cone opsin activity: retinoid analogs as agonists and inverse agonists. Methods Mol Biol. 2010; 652:85-94. PMID: 20552423.
      View in: PubMed
    40. Estevez ME, Kolesnikov AV, Ala-Laurila P, Crouch RK, Govardovskii VI, Cornwall MC. The 9-methyl group of retinal is essential for rapid Meta II decay and phototransduction quenching in red cones. J Gen Physiol. 2009 Aug; 134(2):137-50. PMID: 19635855.
      View in: PubMed
    41. Gonzalez-Fernandez F, Bevilacqua T, Lee KI, Chandrashekar R, Hsu L, Garlipp MA, Griswold JB, Crouch RK, Ghosh D. Retinol-binding site in interphotoreceptor retinoid-binding protein (IRBP): a novel hydrophobic cavity. Invest Ophthalmol Vis Sci. 2009 Dec; 50(12):5577-86. PMID: 19608538.
      View in: PubMed
    42. Isayama T, McCabe England SL, Crouch RK, Zimmerman AL, Makino CL. Beta-ionone activates and bleaches visual pigment in salamander photoreceptors. Vis Neurosci. 2009 May-Jun; 26(3):267-74. PMID: 19500430.
      View in: PubMed
    43. Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K. Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry. 2009 May 26; 48(20):4294-304. PMID: 19348429.
      View in: PubMed
    44. Farjo KM, Moiseyev G, Takahashi Y, Crouch RK, Ma JX. The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins. Invest Ophthalmol Vis Sci. 2009 Nov; 50(11):5089-97. PMID: 19458327.
      View in: PubMed
    45. Kunchithapautham K, Coughlin B, Crouch RK, Rohrer B. Cone outer segment morphology and cone function in the Rpe65-/- Nrl-/- mouse retina are amenable to retinoid replacement. Invest Ophthalmol Vis Sci. 2009 Oct; 50(10):4858-64. PMID: 19407011.
      View in: PubMed
    46. Ala-Laurila P, Cornwall MC, Crouch RK, Kono M. The action of 11-cis-retinol on cone opsins and intact cone photoreceptors. J Biol Chem. 2009 Jun 12; 284(24):16492-500. PMID: 19386593.
      View in: PubMed
    47. Parker RO, Fan J, Nickerson JM, Liou GI, Crouch RK. Normal cone function requires the interphotoreceptor retinoid binding protein. J Neurosci. 2009 Apr 08; 29(14):4616-21. PMID: 19357286.
      View in: PubMed
    48. Takahashi Y, Moiseyev G, Ablonczy Z, Chen Y, Crouch RK, Ma JX. Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65. J Biol Chem. 2009 Jan 30; 284(5):3211-8. PMID: 19049981.
      View in: PubMed
    49. Kono M, Goletz PW, Crouch RK. 11-cis- and all-trans-retinols can activate rod opsin: rational design of the visual cycle. Biochemistry. 2008 Jul 15; 47(28):7567-71. PMID: 18563917.
      View in: PubMed
    50. Zhang H, Fan J, Li S, Karan S, Rohrer B, Palczewski K, Frederick JM, Crouch RK, Baehr W. Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci. 2008 Apr 09; 28(15):4008-14. PMID: 18400900.
      View in: PubMed
    51. Jackson W, Ablonczy Z, Crouch RK. Quantitation of the effect of hydroxylamine on rhodopsin palmitylation. Photochem Photobiol. 2008 Jul-Aug; 84(4):949-55. PMID: 18399918.
      View in: PubMed
    52. Lai K, Conway RM, Crouch R, Jager MJ, Madigan MC. Expression and distribution of MMPs and TIMPs in human uveal melanoma. Exp Eye Res. 2008 Jun; 86(6):936-41. PMID: 18423620.
      View in: PubMed
    53. Chen Y, Znoiko S, DeGrip WJ, Crouch RK, Ma JX. Salamander blue-sensitive cones lost during metamorphosis. Photochem Photobiol. 2008 Jul-Aug; 84(4):855-62. PMID: 18331398.
      View in: PubMed
    54. Fan J, Rohrer B, Frederick JM, Baehr W, Crouch RK. Rpe65-/- and Lrat-/- mice: comparable models of leber congenital amaurosis. Invest Ophthalmol Vis Sci. 2008 Jun; 49(6):2384-9. PMID: 18296659.
      View in: PubMed
    55. Ala-Laurila P, Donner K, Crouch RK, Cornwall MC. Chromophore switch from 11-cis-dehydroretinal (A2) to 11-cis-retinal (A1) decreases dark noise in salamander red rods. J Physiol. 2007 Nov 15; 585(Pt 1):57-74. PMID: 17884920.
      View in: PubMed
    56. Wu Q, Blakeley LR, Cornwall MC, Crouch RK, Wiggert BN, Koutalos Y. Interphotoreceptor retinoid-binding protein is the physiologically relevant carrier that removes retinol from rod photoreceptor outer segments. Biochemistry. 2007 Jul 24; 46(29):8669-79. PMID: 17602665.
      View in: PubMed
    57. Estevez ME, Ala-Laurila P, Crouch RK, Cornwall MC. Turning cones off: the role of the 9-methyl group of retinal in red cones. J Gen Physiol. 2006 Dec; 128(6):671-85. PMID: 17101818.
      View in: PubMed
    58. Fan J, Wu BX, Sarna T, Rohrer B, Redmond TM, Crouch RK. 9-cis Retinal increased in retina of RPE65 knockout mice with decrease in coat pigmentation. Photochem Photobiol. 2006 Nov-Dec; 82(6):1461-7. PMID: 16553465.
      View in: PubMed
    59. Isayama T, Chen Y, Kono M, Degrip WJ, Ma JX, Crouch RK, Makino CL. Differences in the pharmacological activation of visual opsins. Vis Neurosci. 2006 Nov-Dec; 23(6):899-908. PMID: 17266782.
      View in: PubMed
    60. Kolesnikov AV, Ala-Laurila P, Shukolyukov SA, Crouch RK, Wiggert B, Estevez ME, Govardovskii VI, Cornwall MC. Visual cycle and its metabolic support in gecko photoreceptors. Vision Res. 2007 Feb; 47(3):363-74. PMID: 17049961.
      View in: PubMed
    61. Ablonczy Z, Kono M, Knapp DR, Crouch RK. Palmitylation of cone opsins. Vision Res. 2006 Dec; 46(27):4493-501. PMID: 16989884.
      View in: PubMed
    62. Ala-Laurila P, Kolesnikov AV, Crouch RK, Tsina E, Shukolyukov SA, Govardovskii VI, Koutalos Y, Wiggert B, Estevez ME, Cornwall MC. Visual cycle: Dependence of retinol production and removal on photoproduct decay and cell morphology. J Gen Physiol. 2006 Aug; 128(2):153-69. PMID: 16847097.
      View in: PubMed
    63. Lindsey Rose KM, Gourdie RG, Prescott AR, Quinlan RA, Crouch RK, Schey KL. The C terminus of lens aquaporin 0 interacts with the cytoskeletal proteins filensin and CP49. Invest Ophthalmol Vis Sci. 2006 Apr; 47(4):1562-70. PMID: 16565393.
      View in: PubMed
    64. Karnaukhova E, Schey KL, Crouch RK. Circular dichroism and cross-linking studies of bacteriorhodopsin mutants. Amino Acids. 2006 Feb; 30(1):17-23. PMID: 16477391.
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    65. Rohrer B, Crouch R. Rod and cone pigment regeneration in RPE65-/- mice. Adv Exp Med Biol. 2006; 572:101-7. PMID: 17249562.
      View in: PubMed
    66. Moiseyev G, Takahashi Y, Chen Y, Gentleman S, Redmond TM, Crouch RK, Ma JX. RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle. J Biol Chem. 2006 Feb 03; 281(5):2835-40. PMID: 16319067.
      View in: PubMed
    67. Marneros AG, Fan J, Yokoyama Y, Gerber HP, Ferrara N, Crouch RK, Olsen BR. Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function. Am J Pathol. 2005 Nov; 167(5):1451-9. PMID: 16251428.
      View in: PubMed
    68. Horrigan DM, Tetreault ML, Tsomaia N, Vasileiou C, Borhan B, Mierke DF, Crouch RK, Zimmerman AL. Defining the retinoid binding site in the rod cyclic nucleotide-gated channel. J Gen Physiol. 2005 Nov; 126(5):453-60. PMID: 16230468.
      View in: PubMed
    69. Rohrer B, Lohr HR, Humphries P, Redmond TM, Seeliger MW, Crouch RK. Cone opsin mislocalization in Rpe65-/- mice: a defect that can be corrected by 11-cis retinal. Invest Ophthalmol Vis Sci. 2005 Oct; 46(10):3876-82. PMID: 16186377.
      View in: PubMed
    70. Fan J, Woodruff ML, Cilluffo MC, Crouch RK, Fain GL. Opsin activation of transduction in the rods of dark-reared Rpe65 knockout mice. J Physiol. 2005 Oct 01; 568(Pt 1):83-95. PMID: 15994181.
      View in: PubMed
    71. Kefalov VJ, Estevez ME, Kono M, Goletz PW, Crouch RK, Cornwall MC, Yau KW. Breaking the covalent bond--a pigment property that contributes to desensitization in cones. Neuron. 2005 Jun 16; 46(6):879-90. PMID: 15953417.
      View in: PubMed
    72. Ablonczy Z, Darrow RM, Knapp DR, Organisciak DT, Crouch RK. Rhodopsin phosphorylation in rats exposed to intense light. Photochem Photobiol. 2005 May-Jun; 81(3):541-7. PMID: 15504085.
      View in: PubMed
    73. Wang Z, Wen XH, Ablonczy Z, Crouch RK, Makino CL, Lem J. Enhanced shutoff of phototransduction in transgenic mice expressing palmitoylation-deficient rhodopsin. J Biol Chem. 2005 Jul 01; 280(26):24293-300. PMID: 15851469.
      View in: PubMed
    74. Ablonczy Z, Crouch RK, Knapp DR. Mass spectrometric analysis of integral membrane proteins at the subpicomolar level: application to rhodopsin. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Oct 25; 825(2):169-75. PMID: 16213448.
      View in: PubMed
    75. Znoiko SL, Rohrer B, Lu K, Lohr HR, Crouch RK, Ma JX. Downregulation of cone-specific gene expression and degeneration of cone photoreceptors in the Rpe65-/- mouse at early ages. Invest Ophthalmol Vis Sci. 2005 Apr; 46(4):1473-9. PMID: 15790918.
      View in: PubMed
    76. Ervin LA, Ball LE, Crouch RK, Schey KL. Phosphorylation and glycosylation of bovine lens MP20. Invest Ophthalmol Vis Sci. 2005 Feb; 46(2):627-35. PMID: 15671292.
      View in: PubMed
    77. Kono M, Crouch RK, Oprian DD. A dark and constitutively active mutant of the tiger salamander UV pigment. Biochemistry. 2005 Jan 18; 44(2):799-804. PMID: 15641808.
      View in: PubMed
    78. Chen C, Tsina E, Cornwall MC, Crouch RK, Vijayaraghavan S, Koutalos Y. Reduction of all-trans retinal to all-trans retinol in the outer segments of frog and mouse rod photoreceptors. Biophys J. 2005 Mar; 88(3):2278-87. PMID: 15626704.
      View in: PubMed
    79. Wu BX, Moiseyev G, Chen Y, Rohrer B, Crouch RK, Ma JX. Identification of RDH10, an All-trans Retinol Dehydrogenase, in Retinal Muller Cells. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):3857-62. PMID: 15505029.
      View in: PubMed
    80. Tsina E, Chen C, Koutalos Y, Ala-Laurila P, Tsacopoulos M, Wiggert B, Crouch RK, Cornwall MC. Physiological and microfluorometric studies of reduction and clearance of retinal in bleached rod photoreceptors. J Gen Physiol. 2004 Oct; 124(4):429-43. PMID: 15452202.
      View in: PubMed
    81. Wang X, Kim SH, Ablonczy Z, Crouch RK, Knapp DR. Probing rhodopsin-transducin interactions by surface modification and mass spectrometry. Biochemistry. 2004 Sep 07; 43(35):11153-62. PMID: 15366925.
      View in: PubMed
    82. Ball LE, Garland DL, Crouch RK, Schey KL. Post-translational modifications of aquaporin 0 (AQP0) in the normal human lens: spatial and temporal occurrence. Biochemistry. 2004 Aug 03; 43(30):9856-65. PMID: 15274640.
      View in: PubMed
    83. Das J, Crouch RK, Ma JX, Oprian DD, Kono M. Role of the 9-methyl group of retinal in cone visual pigments. Biochemistry. 2004 May 11; 43(18):5532-8. PMID: 15122919.
      View in: PubMed
    84. Marneros AG, Keene DR, Hansen U, Fukai N, Moulton K, Goletz PL, Moiseyev G, Pawlyk BS, Halfter W, Dong S, Shibata M, Li T, Crouch RK, Bruckner P, Olsen BR. Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J. 2004 Jan 14; 23(1):89-99. PMID: 14685281.
      View in: PubMed
    85. Chen Y, Moiseyev G, Wu BX, Ma JX, Crouch RK. Visual cycle retinoid processing proteins are present in HEK293S cells. Vision Res. 2003 Dec; 43(28):3037-44. PMID: 14611939.
      View in: PubMed
    86. Ball LE, Little M, Nowak MW, Garland DL, Crouch RK, Schey KL. Water permeability of C-terminally truncated aquaporin 0 (AQP0 1-243) observed in the aging human lens. Invest Ophthalmol Vis Sci. 2003 Nov; 44(11):4820-8. PMID: 14578404.
      View in: PubMed
    87. Fan J, Rohrer B, Moiseyev G, Ma JX, Crouch RK. Isorhodopsin rather than rhodopsin mediates rod function in RPE65 knock-out mice. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13662-7. PMID: 14578454.
      View in: PubMed
    88. Chen Y, Ma JX, Crouch RK. Down-regulation of RPE65 protein expression and promoter activity by retinoic acid. Mol Vis. 2003 Aug 05; 9:345-54. PMID: 12910240.
      View in: PubMed
    89. Darden AG, Wu BX, Znoiko SL, Hazard ES, Kono M, Crouch RK, Ma JX. A novel Xenopus SWS2, P434 visual pigment: structure, cellular location, and spectral analyses. Mol Vis. 2003 May 16; 9:191-9. PMID: 12764253.
      View in: PubMed
    90. Li Y, Madigan MC, Lai K, Conway RM, Billson FA, Crouch R, Allen BJ. Human uveal melanoma expresses NG2 immunoreactivity. Br J Ophthalmol. 2003 May; 87(5):629-32. PMID: 12714409.
      View in: PubMed
    91. Gresh J, Goletz PW, Crouch RK, Rohrer B. Structure-function analysis of rods and cones in juvenile, adult, and aged C57bl/6 and Balb/c mice. Vis Neurosci. 2003 Mar-Apr; 20(2):211-20. PMID: 12916741.
      View in: PubMed
    92. Dale J, Higgins J, Williams S, Foster T, Snooks H, Crouch R, Hartley-Sharpe C, Glucksman E, Hooper R, George S. Computer assisted assessment and advice for "non-serious" 999 ambulance service callers: the potential impact on ambulance despatch. Emerg Med J. 2003 Mar; 20(2):178-83. PMID: 12642540.
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    93. Moiseyev G, Crouch RK, Goletz P, Oatis J, Redmond TM, Ma JX. Retinyl esters are the substrate for isomerohydrolase. Biochemistry. 2003 Feb 25; 42(7):2229-38. PMID: 12590612.
      View in: PubMed
    94. Cornwall MC, Tsina E, Crouch RK, Wiggert B, Chen C, Koutalos Y. Regulation of the visual cycle: retinol dehydrogenase and retinol fluorescence measurements in vertebrate retina. Adv Exp Med Biol. 2003; 533:353-60. PMID: 15180285.
      View in: PubMed
    95. Rohrer B, Goletz P, Znoiko S, Ablonczy Z, Ma JX, Redmond TM, Crouch RK. Correlation of regenerable opsin with rod ERG signal in Rpe65-/- mice during development and aging. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):310-5. PMID: 12506090.
      View in: PubMed
    96. Rohrer B, Ablonczy Z, Znoiko S, Redmond M, Ma JX, Crouch R. Does constitutive phosphorylation protect against photoreceptor degeneration in Rpe65-/- mice? Adv Exp Med Biol. 2003; 533:221-7. PMID: 15180268.
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    97. Wu BX, Chen Y, Chen Y, Fan J, Rohrer B, Crouch RK, Ma JX. Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE. Invest Ophthalmol Vis Sci. 2002 Nov; 43(11):3365-72. PMID: 12407145.
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    98. Ablonczy Z, Crouch RK, Goletz PW, Redmond TM, Knapp DR, Ma JX, Rohrer B. 11-cis-retinal reduces constitutive opsin phosphorylation and improves quantum catch in retinoid-deficient mouse rod photoreceptors. J Biol Chem. 2002 Oct 25; 277(43):40491-8. PMID: 12176991.
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    99. Znoiko SL, Crouch RK, Moiseyev G, Ma JX. Identification of the RPE65 protein in mammalian cone photoreceptors. Invest Ophthalmol Vis Sci. 2002 May; 43(5):1604-9. PMID: 11980880.
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    100. Ablonczy Z, Goletz P, Knapp DR, Crouch RK. Mass spectrometric analysis of porcine rhodopsin. Photochem Photobiol. 2002 Mar; 75(3):316-21. PMID: 11950099.
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    101. Knapp DR, Crouch RK, Ball LE, Gelasco AK, Ablonczy Z. Mass spectrometric analysis of G protein-coupled receptors. Methods Enzymol. 2002; 343:157-61. PMID: 11665563.
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    102. Gelasco AK, Crouch RK, Knapp DR. Probing the higher order structure of G protein-coupled receptors using tethered cleavage methods. Methods Enzymol. 2002; 343:162-70. PMID: 11665564.
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    103. Crouch RK, Kefalov V, Gärtner W, Cornwall MC. Use of retinal analogues for the study of visual pigment function. Methods Enzymol. 2002; 343:29-48. PMID: 11665574.
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    104. Pepperberg DR, Crouch RK. An illuminating new step in visual-pigment regeneration. Lancet. 2001 Dec 22-29; 358(9299):2098-9. PMID: 11784619.
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    105. Ma J, Znoiko S, Othersen KL, Ryan JC, Das J, Isayama T, Kono M, Oprian DD, Corson DW, Cornwall MC, Cameron DA, Harosi FI, Makino CL, Crouch RK. A visual pigment expressed in both rod and cone photoreceptors. Neuron. 2001 Nov 08; 32(3):451-61. PMID: 11709156.
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    106. Imasheva ES, Lu M, Balashov SP, Ebrey TG, Chen Y, Ablonczy Z, Menick DR, Crouch RK. Exploring the function of Tyr83 in bacteriorhodopsin: features of the Y83F and Y83N mutants. Biochemistry. 2001 Nov 06; 40(44):13320-30. PMID: 11683642.
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    107. Ablonczy Z, Kono M, Crouch RK, Knapp DR. Mass spectrometric analysis of integral membrane proteins at the subnanomolar level: application to recombinant photopigments. Anal Chem. 2001 Oct 15; 73(20):4774-9. PMID: 11681450.
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    108. Matthews HR, Cornwall MC, Crouch RK. Prolongation of actions of Ca2+ early in phototransduction by 9-demethylretinal. J Gen Physiol. 2001 Oct; 118(4):377-90. PMID: 11585850.
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    109. Ryan JC, Crouch RK, Ma JX. Cloning and characterization of three salamander retinal G-protein beta subunits. Mol Vis. 2001 Oct 01; 7:222-7. PMID: 11590364.
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    110. Ma J, Zhang J, Othersen KL, Moiseyev G, Ablonczy Z, Redmond TM, Chen Y, Crouch RK. Expression, purification, and MALDI analysis of RPE65. Invest Ophthalmol Vis Sci. 2001 Jun; 42(7):1429-35. PMID: 11381042.
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    111. Ma JX, Kono M, Xu L, Das J, Ryan JC, Hazard ES, Oprian DD, Crouch RK. Salamander UV cone pigment: sequence, expression, and spectral properties. Vis Neurosci. 2001 May-Jun; 18(3):393-9. PMID: 11497415.
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    112. Kefalov VJ, Crouch RK, Cornwall MC. Role of noncovalent binding of 11-cis-retinal to opsin in dark adaptation of rod and cone photoreceptors. Neuron. 2001 Mar; 29(3):749-55. PMID: 11301033.
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    113. Ryan JC, Znoiko S, Xu L, Crouch RK, Ma JX. Salamander rods and cones contain distinct transducin alpha subunits. Vis Neurosci. 2000 Nov-Dec; 17(6):847-54. PMID: 11193101.
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    114. Das J, Crouch RK, Chong PL. Fluorescence properties of pyrylretinol. Photochem Photobiol. 2000 Sep; 72(3):415-20. PMID: 10989614.
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    115. Corson DW, Kefalov VJ, Cornwall MC, Crouch RK. Effect of 11-cis 13-demethylretinal on phototransduction in bleach-adapted rod and cone photoreceptors. J Gen Physiol. 2000 Aug; 116(2):283-97. PMID: 10919871.
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    116. Ablonczy Z, Knapp DR, Darrow R, Organisciak DT, Crouch RK. Mass spectrometric analysis of rhodopsin from light damaged rats. Mol Vis. 2000 Jun 27; 6:109-15. PMID: 10874059.
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    117. Gelasco A, Crouch RK, Knapp DR. Intrahelical arrangement in the integral membrane protein rhodopsin investigated by site-specific chemical cleavage and mass spectrometry. Biochemistry. 2000 Apr 25; 39(16):4907-14. PMID: 10769149.
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    118. Lu M, Balashov SP, Ebrey TG, Chen N, Chen Y, Menick DR, Crouch RK. Evidence for the rate of the final step in the bacteriorhodopsin photocycle being controlled by the proton release group: R134H mutant. Biochemistry. 2000 Mar 07; 39(9):2325-31. PMID: 10694399.
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    119. Lou J, Tan Q, Karnaukhova E, Berova N, Nakanishi K, Crouch RK. Synthetic retinals: convenient probes of rhodopsin and visual transduction process. Methods Enzymol. 2000; 315:219-37. PMID: 10736705.
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    120. Schey KL, Little M, Fowler JG, Crouch RK. Characterization of human lens major intrinsic protein structure. Invest Ophthalmol Vis Sci. 2000 Jan; 41(1):175-82. PMID: 10634618.
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    121. Das J, Crouch RK, Govindjee R, Balashov S, Ebrey T. Studies on pyrylretinal analogues of bacteriorhodopsin. Photochem Photobiol. 1999 Dec; 70(6):949-56. PMID: 10628308.
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    122. Imasheva ES, Balashov SP, Ebrey TG, Chen N, Crouch RK, Menick DR. Two groups control light-induced Schiff base deprotonation and the proton affinity of Asp85 in the Arg82 his mutant of bacteriorhodopsin. Biophys J. 1999 Nov; 77(5):2750-63. PMID: 10545374.
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    123. Stecher H, Prezhdo O, Das J, Crouch RK, Palczewski K. Isomerization of all-trans-9- and 13-desmethylretinol by retinal pigment epithelial cells. Biochemistry. 1999 Oct 12; 38(41):13542-50. PMID: 10521261.
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    124. Morlet N, Stayt J, Salonikas C, Naidoo D, Crouch R, Graham G, Coroneo M. Etoposide as a virocidal anticytomegalovirus therapy: intravitreal toxicology and pharmacology in rabbits. Aust N Z J Ophthalmol. 1999 Oct; 27(5):342-9. PMID: 10571395.
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    125. Ma JX, Zhang D, Laser M, Brownlee NA, Re GG, Hazen-Martin DJ, Redmond TM, Crouch RK. Identification of RPE65 in transformed kidney cells. FEBS Lett. 1999 Jun 11; 452(3):199-204. PMID: 10386590.
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    126. Datta-Gupta N, Crouch RK, Hazard ES. Categorizing reactivity of bacteriorhodopsin cysteine mutants crosslinking to 4-bromoretinal. Biochem Mol Biol Int. 1999 May; 47(5):773-80. PMID: 10365248.
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    127. Kefalov VJ, Carter Cornwall M, Crouch RK. Occupancy of the chromophore binding site of opsin activates visual transduction in rod photoreceptors. J Gen Physiol. 1999 Mar; 113(3):491-503. PMID: 10051522.
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    128. Balashov SP, Lu M, Imasheva ES, Govindjee R, Ebrey TG, Othersen B, Chen Y, Crouch RK, Menick DR. The proton release group of bacteriorhodopsin controls the rate of the final step of its photocycle at low pH. Biochemistry. 1999 Feb 16; 38(7):2026-39. PMID: 10026285.
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    129. Redmond TM, Yu S, Lee E, Bok D, Hamasaki D, Chen N, Goletz P, Ma JX, Crouch RK, Pfeifer K. Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nat Genet. 1998 Dec; 20(4):344-51. PMID: 9843205.
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    130. Ma J, Xu L, Othersen DK, Redmond TM, Crouch RK. Cloning and localization of RPE65 mRNA in salamander cone photoreceptor cells1. Biochim Biophys Acta. 1998 Nov 26; 1443(1-2):255-61. PMID: 9838153.
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    131. Finley EL, Dillon J, Crouch RK, Schey KL. Identification of tryptophan oxidation products in bovine alpha-crystallin. Protein Sci. 1998 Nov; 7(11):2391-7. PMID: 9828005.
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    132. Dale J, Crouch R, Lloyd D. Primary care: nurse-led telephone triage and advice out-of-hours. Nurs Stand. 1998 Aug 12-18; 12(47):41-5. PMID: 9752159.
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    133. Xu L, Hazard ES, Lockman DK, Crouch RK, Ma J. Molecular cloning of the salamander red and blue cone visual pigments. Mol Vis. 1998 Jul 15; 4:10. PMID: 9675215.
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    134. Finley EL, Dillon J, Crouch RK, Schey KL. Radiolysis-induced oxidation of bovine alpha-crystallin. Photochem Photobiol. 1998 Jul; 68(1):9-15. PMID: 9679446.
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    135. Ball LE, Oatis JE, Dharmasiri K, Busman M, Wang J, Cowden LB, Galijatovic A, Chen N, Crouch RK, Knapp DR. Mass spectrometric analysis of integral membrane proteins: application to complete mapping of bacteriorhodopsins and rhodopsin. Protein Sci. 1998 Mar; 7(3):758-64. PMID: 9541408.
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    136. Misra S, Martin C, Kwon OH, Ebrey TG, Chen N, Crouch RK, Menick DR. Mutation of arginine 134 to lysine alters the pK(a)s of key groups involved in proton pumping by bacteriorhodopsin. Photochem Photobiol. 1997 Dec; 66(6):774-83. PMID: 9421964.
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    137. Finley EL, Busman M, Dillon J, Crouch RK, Schey KL. Identification of photooxidation sites in bovine alpha-crystallin. Photochem Photobiol. 1997 Nov; 66(5):635-41. PMID: 9383987.
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    138. Schey KL, Fowler JG, Schwartz JC, Busman M, Dillon J, Crouch RK. Complete map and identification of the phosphorylation site of bovine lens major intrinsic protein. Invest Ophthalmol Vis Sci. 1997 Nov; 38(12):2508-15. PMID: 9375569.
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    139. Patel A, Dale J, Crouch R. Satisfaction with telephone advice from an accident and emergency department: identifying areas for service improvement. Qual Health Care. 1997 Sep; 6(3):140-5. PMID: 10173771.
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    140. Balashov SP, Imasheva ES, Ebrey TG, Chen N, Menick DR, Crouch RK. Glutamate-194 to cysteine mutation inhibits fast light-induced proton release in bacteriorhodopsin. Biochemistry. 1997 Jul 22; 36(29):8671-6. PMID: 9289012.
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    141. Misra S, Ebrey TG, Crouch RK, Menick DR. Charge movements in the 13-cis photocycles of the bacteriorhodopsin mutants R82K and R82Q. Photochem Photobiol. 1997 Jun; 65(6):1039-44. PMID: 9188284.
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    142. Martinez LM, Crouch RK, Corson DW. Application of a submicroliter spectrophotometer in visual pigment studies. Mol Vis. 1997 Apr 30; 3:4. PMID: 9238093.
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    143. Misra S, Govindjee R, Ebrey TG, Chen N, Ma JX, Crouch RK. Proton uptake and release are rate-limiting steps in the photocycle of the bacteriorhodopsin mutant E204Q. Biochemistry. 1997 Apr 22; 36(16):4875-83. PMID: 9125508.
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    144. Govindjee R, Imasheva ES, Misra S, Balashov SP, Ebrey TG, Chen N, Menick DR, Crouch RK. Mutation of a surface residue, lysine-129, reverses the order of proton release and uptake in bacteriorhodopsin; guanidine hydrochloride restores it. Biophys J. 1997 Feb; 72(2 Pt 1):886-98. PMID: 9017214.
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    145. Dale J, Williams S, Crouch R, Patel A. A study of out-of-hours telephone advice from an A&E department. Br J Nurs. 1997 Feb 13-26; 6(3):171-4. PMID: 9104124.
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    146. Bradshaw TP, McMillan DC, Crouch RK, Jollow DJ. Formation of free radicals and protein mixed disulfides in rat red cells exposed to dapsone hydroxylamine. Free Radic Biol Med. 1997; 22(7):1183-93. PMID: 9098092.
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    147. Ma JX, King LP, Yang Z, Crouch RK, Chao L, Chao J. Kallistatin in human ocular tissues: reduced levels in vitreous fluids from patients with diabetic retinopathy. Curr Eye Res. 1996 Nov; 15(11):1117-23. PMID: 8950506.
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    148. Crouch R, Patel A, Dale J. Paediatric calls to an inner city accident and emergency department: service demand and advice given. Accid Emerg Nurs. 1996 Oct; 4(4):170-4. PMID: 8981836.
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    149. Crouch RK, Chader GJ, Wiggert B, Pepperberg DR. Retinoids and the visual process. Photochem Photobiol. 1996 Oct; 64(4):613-21. PMID: 8863467.
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    150. Buczylko J, Saari JC, Crouch RK, Palczewski K. Mechanisms of opsin activation. J Biol Chem. 1996 Aug 23; 271(34):20621-30. PMID: 8702809.
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    151. Govindjee R, Misra S, Balashov SP, Ebrey TG, Crouch RK, Menick DR. Arginine-82 regulates the pKa of the group responsible for the light-driven proton release in bacteriorhodopsin. Biophys J. 1996 Aug; 71(2):1011-23. PMID: 8842238.
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    152. Chen N, Ma JX, Corson DW, Hazard ES, Crouch RK. Molecular cloning of a rhodopsin gene from salamander rods. Invest Ophthalmol Vis Sci. 1996 Aug; 37(9):1907-13. PMID: 8759361.
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    153. Ma JX, Song Q, Hatcher HC, Crouch RK, Chao L, Chao J. Expression and cellular localization of the kallikrein-kinin system in human ocular tissues. Exp Eye Res. 1996 Jul; 63(1):19-26. PMID: 8983960.
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    154. Crouch R, Patel A, Williams S, Dale J. An analysis of telephone calls to an inner-city accident and emergency department. J R Soc Med. 1996 Jun; 89(6):324-8. PMID: 8758190.
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    155. Corson DW, Crouch RK. Physiological activity of retinoids in natural and artificial visual pigments. Photochem Photobiol. 1996 May; 63(5):595-600. PMID: 8628750.
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    156. Cornwall MC, Matthews HR, Crouch RK, Fain GL. Bleached pigment activates transduction in salamander cones. J Gen Physiol. 1995 Sep; 106(3):543-57. PMID: 8786347.
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    157. Balashov SP, Govindjee R, Imasheva ES, Misra S, Ebrey TG, Feng Y, Crouch RK, Menick DR. The two pKa's of aspartate-85 and control of thermal isomerization and proton release in the arginine-82 to lysine mutant of bacteriorhodopsin. Biochemistry. 1995 Jul 11; 34(27):8820-34. PMID: 7612623.
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    158. Morrison DF, Ting TD, Vallury V, Ho YK, Crouch RK, Corson DW, Mangini NJ, Pepperberg DR. Reduced light-dependent phosphorylation of an analog visual pigment containing 9-demethylretinal as its chromophore. J Biol Chem. 1995 Mar 24; 270(12):6718-21. PMID: 7896815.
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    159. Khachigian LM, Field SL, Crouch R, Chesterman CN. Platelet-derived growth factor A-chain synthetic peptide inhibits human glioma xenograft proliferation in nude mice. Anticancer Res. 1995 Mar-Apr; 15(2):337-41. PMID: 7763003.
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    160. Bradshaw TP, McMillan DC, Crouch RK, Jollow DJ. Identification of free radicals produced in rat erythrocytes exposed to hemolytic concentrations of phenylhydroxylamine. Free Radic Biol Med. 1995 Feb; 18(2):279-85. PMID: 7744312.
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    161. Palczewski K, Jäger S, Buczylko J, Crouch RK, Bredberg DL, Hofmann KP, Asson-Batres MA, Saari JC. Rod outer segment retinol dehydrogenase: substrate specificity and role in phototransduction. Biochemistry. 1994 Nov 22; 33(46):13741-50. PMID: 7947785.
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    162. Feng Y, Menick DR, Katz BM, Beischel CJ, Hazard ES, Misra S, Ebrey TG, Crouch RK. Probing of the retinal binding site of bacteriorhodopsin by affinity labeling. Biochemistry. 1994 Sep 27; 33(38):11624-30. PMID: 7918376.
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    163. Crouch R, Dale J. Identifying feelings engendered during triage assessment in the accident and emergency department: the use of visual analogue scales. J Clin Nurs. 1994 Sep; 3(5):289-97. PMID: 7834139.
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    164. Corson DW, Cornwall MC, MacNichol EF, Tsang S, Derguini F, Crouch RK, Nakanishi K. Relief of opsin desensitization and prolonged excitation of rod photoreceptors by 9-desmethylretinal. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):6958-62. PMID: 8041729.
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    165. Beischel CJ, Knapp DR, Govindjee R, Ebrey TG, Crouch RK. Azidotetrafluorophenyl retinal analogue: synthesis and bacteriorhodopsin pigment formation. Photochem Photobiol. 1994 Jul; 60(1):64-8. PMID: 7794419.
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    166. Beischel CJ, Gray K, Hazard ES, Knapp DR, Crouch RK. Evaluation of photoaffinity labeled sites of bacteriorhodopsin using molecular modeling. Biochem Mol Biol Int. 1994 Apr; 32(5):933-9. PMID: 8069243.
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    167. Balashov SP, Govindjee R, Kono M, Imasheva E, Lukashev E, Ebrey TG, Crouch RK, Menick DR, Feng Y. Effect of the arginine-82 to alanine mutation in bacteriorhodopsin on dark adaptation, proton release, and the photochemical cycle. Biochemistry. 1993 Oct 05; 32(39):10331-43. PMID: 8399176.
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    168. Jin J, Crouch RK, Corson DW, Katz BM, MacNichol EF, Cornwall MC. Noncovalent occupancy of the retinal-binding pocket of opsin diminishes bleaching adaptation of retinal cones. Neuron. 1993 Sep; 11(3):513-22. PMID: 8398144.
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    169. Finch JW, Crouch RK, Knapp DR, Schey KL. Mass spectrometric identification of modifications to human serum albumin treated with hydrogen peroxide. Arch Biochem Biophys. 1993 Sep; 305(2):595-9. PMID: 8373198.
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    170. Papac DI, Oatis JE, Crouch RK, Knapp DR. Mass spectrometric identification of phosphorylation sites in bleached bovine rhodopsin. Biochemistry. 1993 Jun 15; 32(23):5930-4. PMID: 8507634.
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    171. Callahan HL, Hazen-Martin D, Crouch RK, James ER. Immunolocalization of superoxide dismutase in Dirofilaria immitis adult worms. Infect Immun. 1993 Mar; 61(3):1157-63. PMID: 8432599.
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    172. Pepperberg DR, Okajima TL, Wiggert B, Ripps H, Crouch RK, Chader GJ. Interphotoreceptor retinoid-binding protein (IRBP). Molecular biology and physiological role in the visual cycle of rhodopsin. Mol Neurobiol. 1993; 7(1):61-85. PMID: 8318167.
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    173. Hazard ES, Govindjee R, Ebrey TG, Crouch RK. Biosynthetic incorporation of m-fluorotyrosine into bacteriorhodopsin. Photochem Photobiol. 1992 Dec; 56(6):929-34. PMID: 1492136.
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    174. Zhu L, Crouch RK. Albumin in the cornea is oxidized by hydrogen peroxide. Cornea. 1992 Nov; 11(6):567-72. PMID: 1468220.
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    175. Schey KL, Papac DI, Knapp DR, Crouch RK. Matrix-assisted laser desorption mass spectrometry of rhodopsin and bacteriorhodopsin. Biophys J. 1992 Nov; 63(5):1240-3. PMID: 1477275.
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    176. Papac DI, Thornburg KR, Büllesbach EE, Crouch RK, Knapp DR. Palmitylation of a G-protein coupled receptor. Direct analysis by tandem mass spectrometry. J Biol Chem. 1992 Aug 25; 267(24):16889-94. PMID: 1512231.
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    177. Crouch RK, Hazard ES, Lind T, Wiggert B, Chader G, Corson DW. Interphotoreceptor retinoid-binding protein and alpha-tocopherol preserve the isomeric and oxidation state of retinol. Photochem Photobiol. 1992 Aug; 56(2):251-5. PMID: 1502268.
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    178. Subczynski WK, Renk GE, Crouch RK, Hyde JS, Kusumi A. Oxygen diffusion-concentration product in rhodopsin as observed by a pulse ESR spin labeling method. Biophys J. 1992 Aug; 63(2):573-7. PMID: 1330032.
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    179. Irié H, Massiello A, Kiraly R, Chen JF, Crouch R, Fukamachi K, Jacobs G, Harasaki H, Golding L, Thomas D, et al. Initial in vivo tests of an electrohydraulic actuated total artificial heart. ASAIO J. 1992 Jul-Sep; 38(3):M497-500. PMID: 1457910.
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    180. Fukamachi K, Irié H, Massiello A, Chen JF, Crouch R, Utoh J, Harasaki H, Golding LA, Kiraly RJ. Effects of mechanical ventilation and spontaneous respiration on hemodynamics in calves with total artificial hearts. ASAIO J. 1992 Jul-Sep; 38(3):M493-6. PMID: 1457909.
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    181. Beischel CJ, Mani V, Govindjee R, Ebrey TG, Knapp DR, Crouch RK. Ring oxidized retinals form unusual bacteriorhodopsin analogue pigments. Photochem Photobiol. 1991 Dec; 54(6):977-83. PMID: 1775535.
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    182. Callahan HL, Crouch RK, James ER. Dirofilaria immitis superoxide dismutase: purification and characterization. Mol Biochem Parasitol. 1991 Dec; 49(2):245-51. PMID: 1775168.
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    183. Crouch RK, Goletz P, Snyder A, Coles WH. Antioxidant enzymes in human tears. J Ocul Pharmacol. 1991; 7(3):253-8. PMID: 1783856.
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    184. Bradshaw TP, McMillan DC, Crouch RK, Jollow DJ. Arylamine-induced hemolytic anemia: electron spin resonance spectrometry studies. Adv Exp Med Biol. 1991; 283:253-5. PMID: 1648864.
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    185. Corson DW, Cornwall MC, MacNichol EF, Jin J, Johnson R, Derguini F, Crouch RK, Nakanishi K. Sensitization of bleached rod photoreceptors by 11-cis-locked analogues of retinal. Proc Natl Acad Sci U S A. 1990 Sep; 87(17):6823-7. PMID: 2395874.
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    186. Callahan HL, Crouch RK, James ER. Hydrogen peroxide is the most toxic oxygen species for Onchocerca cervicalis microfilariae. Parasitology. 1990 Jun; 100 Pt 3:407-15. PMID: 2163503.
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    187. Good SS, Koble CS, Crouch R, Johnson RL, Rideout JL, de Miranda P. Isolation and characterization of an ether glucuronide of zidovudine, a major metabolite in monkeys and humans. Drug Metab Dispos. 1990 May-Jun; 18(3):321-6. PMID: 1974193.
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    188. Corson DW, Cornwall MC, MacNichol EF, Mani V, Crouch RK. Transduction noise induced by 4-hydroxy retinals in rod photoreceptors. Biophys J. 1990 Jan; 57(1):109-15. PMID: 2297557.
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    189. Hayden BJ, Zhu L, Sens D, Tapert MJ, Crouch RK. Cytolysis of corneal epithelial cells by hydrogen peroxide. Exp Eye Res. 1990 Jan; 50(1):11-6. PMID: 2307190.
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    190. Jones GJ, Crouch RK, Wiggert B, Cornwall MC, Chader GJ. Retinoid requirements for recovery of sensitivity after visual-pigment bleaching in isolated photoreceptors. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9606-10. PMID: 2594788.
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    191. Pepperberg DR, Anderson SM, Crouch R. Activity of rhodopsin in vitamin A-deprived rats: light-dependent binding of G-protein. Curr Eye Res. 1989 Apr; 8(4):423-8. PMID: 2498040.
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    192. Mani V, Crouch RK. Spin trapping of the superoxide anion: complications in the use of the water-soluble nitroso-aromatic reagent DBNBS. J Biochem Biophys Methods. 1989 Mar; 18(2):91-6. PMID: 2545762.
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    193. Callahan HL, Wakeman JM, Crouch RK, James ER. An in vitro radiolabel uptake viability assay for Onchocerca microfilariae. J Parasitol. 1989 Feb; 75(1):142-4. PMID: 2918434.
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    194. Renk G, Crouch RK. Analogue pigment studies of chromophore-protein interactions in metarhodopsins. Biochemistry. 1989 Jan 24; 28(2):907-12. PMID: 2540811.
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    195. Katz SA, Venkatachalam M, Crouch RK, Heffner JE, Halushka PV, Wise WC, Cook JA. Catalase pretreatment attenuates oleic acid-induced edema in isolated rabbit lung. J Appl Physiol (1985). 1988 Sep; 65(3):1301-6. PMID: 3182500.
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    196. Callahan HL, Crouch RK, James ER. Helminth anti-oxidant enzymes: a protective mechanism against host oxidants? Parasitol Today. 1988 Aug; 4(8):218-25. PMID: 15463102.
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    197. Renk GE, Crouch RK, Feix JB. Lack of interaction of rhodopsin chromophore with membrane lipids. An electron-electron double resonance study using 14N:15N pairs. Biophys J. 1988 Mar; 53(3):361-5. PMID: 2832012.
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    198. Crouch RK, Goletz P. Fenretinide does not block visual pigment formation in the rat. J Ocul Pharmacol. 1988; 4(3):253-7. PMID: 2974060.
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    199. Crouch R, Ling Z, Hayden BJ. Corneal oxygen scavenging systems: lysis of corneal epithelial cells by superoxide anions. Basic Life Sci. 1988; 49:1043-6. PMID: 2854974.
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    200. Crouch RK. Studies of rhodopsin and bacteriorhodopsin using modified retinals. Photochem Photobiol. 1986 Dec; 44(6):803-7. PMID: 3550831.
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    201. Neville R, Dennis P, Sens D, Crouch R. Preservative cytotoxicity to cultured corneal epithelial cells. Curr Eye Res. 1986 May; 5(5):367-72. PMID: 3720343.
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    202. Zingoni J, Or YS, Crouch RK, Chang CH, Govindjee R, Ebrey TG. Effect of variation of retinal polyene side-chain length on formation and function of bacteriorhodopsin analogue pigments. Biochemistry. 1986 Apr 22; 25(8):2022-7. PMID: 3707928.
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    203. Crouch RK, Scott R, Ghent S, Govindjee R, Chang CH, Ebrey T. Properties of synthetic bacteriorhodopsin pigments. Further probes of the chromophore binding site. Photochem Photobiol. 1986 Mar; 43(3):297-303. PMID: 3703965.
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    204. Thaete LG, Crouch RK, Spicer SS. Immunolocalization of copper-zinc superoxide dismutase. II. Rat. J Histochem Cytochem. 1985 Aug; 33(8):803-8. PMID: 3894498.
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    205. Rao VJ, Zingoni JP, Crouch R, Denny M, Liu RS. Isomers of 3,7,11-trimethyldodeca-2,4,6,8,10-pentaenal (a linear analogue of retinal) and lower homologues in their interaction with bovine opsin and bacterioopsin. Photochem Photobiol. 1985 Feb; 41(2):171-4. PMID: 3159027.
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    206. Thaete LG, Crouch RK, Spicer SS. Immunolocalization of CuZn superoxide dismutase in striated muscle. Histochem J. 1985 Feb; 17(2):259-62. PMID: 3894300.
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    207. Harlan EW, Crouch R. Canine retinal superoxide dismutase: identity with the erythrocyte enzyme. Curr Eye Res. 1984 Dec; 3(12):1455-9. PMID: 6441679.
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    208. Crouch RK, Patrick J, Goosey J, Coles WH. The effect of age on corneal and lens superoxide dismutase. Curr Eye Res. 1984 Sep; 3(9):1119-23. PMID: 6488863.
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    209. Crouch R, Nodes BR, Perlman JI, Pepperberg DR, Akita H, Nakanishi K. Cycloheptatrienylidene analog of 11-cis retinal. Formation of pigment in photoreceptor membranes. Invest Ophthalmol Vis Sci. 1984 Apr; 25(4):419-28. PMID: 6231263.
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    210. Redmond TM, Duke EJ, Coles WH, Simson JA, Crouch RK. Localization of corneal superoxide dismutase by biochemical and histocytochemical techniques. Exp Eye Res. 1984 Apr; 38(4):369-78. PMID: 6373333.
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    211. Lacy ME, Crouch RK, Lam CF. Computer modeling of the recombination reaction of rhodopsin. Comput Biol Med. 1984; 14(4):403-10. PMID: 6509940.
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    212. Lacy ME, Veronee CD, Crouch RK. Regeneration of rhodopsin and isorhodopsin in rod outer segment preparations: absence of effect of solvent parameters. Physiol Chem Phys Med NMR. 1984; 16(4):275-81. PMID: 6240663.
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    213. Thaete LG, Crouch RK, Schulte BA, Spicer SS. The immunolocalization of copper-zinc superoxide dismutase in canine tissues. J Histochem Cytochem. 1983 Dec; 31(12):1399-406. PMID: 6355288.
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    214. Gandy SE, Buse MG, Sorenson JR, Crouch RK. Attenuation of streptozotocin diabetes with superoxide dismutase-like copper(II)(3,5-diisopropylsalicylate)2 in the rat. Diabetologia. 1983 Jun; 24(6):437-40. PMID: 6224712.
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    215. Gandy SE, Buse MG, Crouch RK. Protective role of superoxide dismutase against diabetogenic drugs. J Clin Invest. 1982 Sep; 70(3):650-8. PMID: 6213639.
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    216. Crouch RK, Chambers JK. Absence of abnormal erythrocyte superoxide dismutase, copper, or zinc levels in patients with retinitis pigmentosa. Br J Ophthalmol. 1982 Jul; 66(7):417-21. PMID: 7093179.
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    217. Crouch RK, Veronee CD, Lacy ME. Inhibition of rhodopsin regeneration by cyclohexyl derivatives. Vision Res. 1982; 22(12):1451-6. PMID: 6222537.
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    218. Crouch RK, Gandy SE, Kimsey G, Galbraith RA, Galbraith GM, Buse MG. The inhibition of islet superoxide dismutase by diabetogenic drugs. Diabetes. 1981 Mar; 30(3):235-41. PMID: 6451462.
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    219. Mao B, Govindjee R, Ebrey TG, Arnaboldi M, Balogh-Nair V, Nakanishi K, Crouch R. Photochemical and functional properties of bacteriorhodopsins formed from 5,6-dihydro- and 5,6-dihydrodesmethylretinals. Biochemistry. 1981 Jan 20; 20(2):428-35. PMID: 7470492.
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    220. Crouch R, Katz S, Nakanishi K, Gawinowicz MA, Balogh-Nair V. Incorporation of 11,12-dihydroretinal into the retinae of vitamin a deprived rats. Photochem Photobiol. 1981 Jan; 33(1):91-5. PMID: 7243905.
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    221. Mao B, Ebrey TG, Crouch R. Bathoproducts of rhodopsin, isorhodopsin I, and isorhodopsin II. Biophys J. 1980 Feb; 29(2):247-56. PMID: 7260250.
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    222. Crouch R, Katz S. The effect of retinal isomers on the VER and ERG of vitamin A deprived rats. Vision Res. 1980; 20(2):109-15. PMID: 7434571.
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    223. Crouch R, Priest DG, Duke EJ. Superoxide dismutase activities of bovine ocular tissues. Exp Eye Res. 1978 Nov; 27(5):503-9. PMID: 720424.
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    224. Crouch R, Pepperberg DR. Sensitizing activity of 9,13-dicis retinal in bleached photoreceptors of the skate. Invest Ophthalmol Vis Sci. 1978 Oct; 17(10):1024-9. PMID: 700952.
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    225. Crouch R, Coffman M. The effect of visible light on the regeneration of rhodopsin. Biochem Biophys Res Commun. 1976 Nov 22; 73(2):428-33. PMID: 999718.
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    226. Crouch R. Photosensitive pigments formed with rat opsin. Invest Ophthalmol. 1976 Oct; 15(10):872-5. PMID: 977259.
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    227. Waddell WH, Crouch R, Nakanishi K, Turro NJ. Quantitative aspects of the photochemistry of isomeric retinals and visual pigments. J Am Chem Soc. 1976 Jul 07; 98(14):4189-92. PMID: 932359.
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    228. Callender RH, Doukas A, Crouch R, Nakanishi K. Molecular flow resonance Raman effect from retinal and rhodopsin. Biochemistry. 1976 Apr 20; 15(8):1621-9. PMID: 1268187.
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    229. Nakanishi K, Yudd AP, Crouch RK, Olson GL, Cheung HC, Govindjee R, Ebrey TG, Patel DJ. Letter: Allenic retinals and visual pigment analogues. J Am Chem Soc. 1976 Jan 07; 98(1):236-8. PMID: 1244368.
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    230. Crouch R, Purvin V, Nakanishi K, Ebrey T. Isorhodopsin II: artificial photosensitive pigment formed from 9,13-dicis retinal. Proc Natl Acad Sci U S A. 1975 Apr; 72(4):1538-42. PMID: 1055424.
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