Robert E. Notari

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InstitutionMedical University of South Carolina
DepartmentSCCP Drug Discovery and Biomedical Sciences - MUSC Campus
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dyar SC, Notari RE. A nomogram to evaluate intrinsic absorption rate constants of potential oral prolonged-release candidates. Pharm Dev Technol. 1999 Aug; 4(3):305-12. PMID: 10434276.
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    2. Fubara JO, Notari RE. Influence of pH, temperature and buffers on cefepime degradation kinetics and stability predictions in aqueous solutions. J Pharm Sci. 1998 Dec; 87(12):1572-6. PMID: 10189269.
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    3. Fubara JO, Notari RE. A kinetic oxymoron: concentration-dependent first-order rate constants for hydrolysis of ceftazidime. J Pharm Sci. 1998 Jan; 87(1):53-8. PMID: 9452968.
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    4. Zhou M, Notari RE. A nomogram to predict the best biological half-life values for candidates for oral prolonged-release formulations. J Pharm Sci. 1996 Aug; 85(8):791-5. PMID: 8863265.
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    5. Zhou M, Notari RE. Methodology for using oral dose pharmacokinetic data to select drugs for prolonged release formulations and validation of the method using simulated data. Biopharm Drug Dispos. 1995 May; 16(4):319-31. PMID: 7548781.
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    6. Zhou M, Notari RE. Influence of pH, temperature, and buffers on the kinetics of ceftazidime degradation in aqueous solutions. J Pharm Sci. 1995 May; 84(5):534-8. PMID: 7658340.
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    7. Wang D, Notari RE. Cefuroxime hydrolysis kinetics and stability predictions in aqueous solution. J Pharm Sci. 1994 Apr; 83(4):577-81. PMID: 8046618.
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    8. Lam CF, Jiang Q, Notari RE. An efficient method for computer-aided dosage form design. Comput Biol Med. 1993 Nov; 23(6):475-82. PMID: 8306626.
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    9. Irvin JR, Notari RE. Computer-aided dosage form design. III. Feasibility assessment for an oral prolonged-release phenytoin product. Pharm Res. 1991 Feb; 8(2):232-7. PMID: 2023873.
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    10. Nguyen NA, Notari RE. Substituent effects on degradation rates and pathways of cytosine nucleosides. J Pharm Sci. 1989 Oct; 78(10):802-6. PMID: 2600783.
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    11. Pfeifer RW, Notari RE. Predicting caffeine plasma concentrations resulting from consumption of food or beverages: a simple method and its origin. Drug Intell Clin Pharm. 1988 Dec; 22(12):953-9. PMID: 3243174.
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    12. Nguyen NA, Notari RE. Potential improvement in shelf life using the prodrug approach. II. A systematic examination of kinetic requirements. Pharm Res. 1988 Oct; 5(10):634-8. PMID: 3244615.
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    13. Nguyen NA, Mortada LM, Notari RE. Potential improvement in the shelf life of parenterals using the prodrug approach: bacampicillin and talampicillin hydrolysis kinetics and utilization time. Pharm Res. 1988 May; 5(5):288-96. PMID: 3244638.
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    14. Lee TY, Notari RE. Computer-aided dosage form design. II. Methods for defining a zero-order sustained-release delivery system of maximum formulating flexibility. Pharm Res. 1987 Oct; 4(5):385-91. PMID: 3508547.
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    15. Lee TY, Notari RE. Computer-aided dosage form design. I. Methods for defining a long-acting first-order delivery system of maximum formulating flexibility. Pharm Res. 1987 Aug; 4(4):311-6. PMID: 3508537.
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    16. Lee TY, Notari RE. Kinetics and mechanism of captopril oxidation in aqueous solution under controlled oxygen partial pressure. Pharm Res. 1987 Apr; 4(2):98-103. PMID: 3334413.
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    17. Pejaver SK, Notari RE. Decreased stability in liposomal suspensions: accelerated loss of p-nitrophenyl acetate. J Pharm Sci. 1985 Nov; 74(11):1167-71. PMID: 4087176.
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    18. Notari RE. Theory and practice of prodrug kinetics. Methods Enzymol. 1985; 112:309-23. PMID: 4046852.
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    19. Kirsch LE, Notari RE. Aqueous conversion kinetics and mechanisms of ancitabine, a prodrug of the antileukemic agent cytarabine. J Pharm Sci. 1984 Jul; 73(7):896-902. PMID: 6206222.
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    20. Kirsch LE, Notari RE. Pharmacokinetic prodrug modeling: in vitro and in vivo kinetics and mechanisms of ancitabine bioconversion to cytarabine. J Pharm Sci. 1984 Jun; 73(6):728-32. PMID: 6204036.
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    21. Kirsch LE, Notari RE. Theoretical basis for the detection of general-base catalysis in the presence of predominating hydroxide catalysis. J Pharm Sci. 1984 Jun; 73(6):724-7. PMID: 6737254.
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    22. D'Silva JB, Notari RE. Drug stability in liposomal suspensions: hydrolysis of indomethacin, cyclocytidine, and p-nitrophenyl acetate. J Pharm Sci. 1982 Dec; 71(12):1394-8. PMID: 6185667.
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    23. Byron PR, Guest RT, Notari RE. Thermodynamic dependence of interfacial transfer kinetics of nonionized barbituric acid derivatives in two-phase transfer cell. J Pharm Sci. 1981 Nov; 70(11):1265-9. PMID: 7299674.
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    24. Notari RE. Prodrug design. Pharmacol Ther. 1981; 14(1):25-53. PMID: 7033999.
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    25. Tomlinson E, Notari RE, Byron PR. Simultaneous partitioning and hydrolysis kinetics of amoxicillin and ampicillin. J Pharm Sci. 1980 Jun; 69(6):655-8. PMID: 7205576.
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    26. Byron PR, Notari RE, Tomlinson E. Calculation of partition coefficient of an unstable compound using kinetic methods. J Pharm Sci. 1980 May; 69(5):527-31. PMID: 7381736.
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    27. D'Silva JB, Notari RE. Stability-indicating colorimetric assay for indicine N-oxide using TLC. J Pharm Sci. 1980 Apr; 69(4):471-2. PMID: 7373551.
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    28. Byron PR, Notari RE, Tomlinson E. Calculation of the partition coefficient of an unstable compound using kinetic methods [proceedings]. J Pharm Pharmacol. 1978 Dec; 30 Suppl:7P. PMID: 32328.
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    29. Byron PR, Notari RE. Critical analysis of "flip-flop" phenomenon in two-compartment pharmacokinetic model. J Pharm Sci. 1976 Aug; 65(8):1140-4. PMID: 978432.
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    30. Reuning RH, Malspeis L, Frank S, Notari RE. Testing of drug delivery systems for use in the treatment of narcotic addiction. Natl Inst Drug Abuse Res Monogr Ser. 1976 Jan; (4):43-5. PMID: 823438.
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    31. Notari RE, DeYoung JL. Kinetics and mechanisms of degradation of the antileukemic agent 5-azacytidine in aqueous solutions. J Pharm Sci. 1975 Jul; 64(7):1148-57. PMID: 50433.
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    32. Reuning RH, Malspeis L, Frank S, Notari RE. Testing of drug delivery systems for use in the treatment of narcotic addiction. Natl Inst Drug Abuse Res Monogr Ser. 1975; (4):43-5. PMID: 827709.
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    33. Notari RE, Kavaliunas DR, Bockbrader HN. Proceedings: Apparent biological half-life values determined by administration of drug by methods other than rapid intravenous injection. J Pharm Pharmacol. 1974 Dec; 26 Suppl:62P-63P. PMID: 4156741.
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    34. Notari RE. Proceedings: Structural effects in pharmacokinetics and drug response. Acta Pharm Suec. 1974 Dec; 11(6):633-5. PMID: 1136785.
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    35. DeYoung JL, Notari RE, Feller DR. Comparative reactivity of cytidine and arabinosylcytosine to their 6-methyl derivatives in the presence of cytidine deaminase. Res Commun Chem Pathol Pharmacol. 1974 Sep; 9(1):163-72. PMID: 4474681.
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    36. Garry PJ, Prince LC, Notari RE. Half-life of human serum cholinesterase following blood transfusion. Res Commun Chem Pathol Pharmacol. 1974 Jun; 8(2):371-80. PMID: 4852217.
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    37. Notari RE. Pharmacokinetics and molecular modification: implications in drug design and evaluation. J Pharm Sci. 1973 Jun; 62(6):865-81. PMID: 4576424.
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    38. Reuning RH, Sams RA, Notari RE. Role of pharmacokinetics in drug dosage adjustment. I. Pharmacologic effect kinetics and apparent volume of distribution of digoxin. J Clin Pharmacol New Drugs. 1973 Apr; 13(4):127-41. PMID: 4487163.
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    39. Notari RE, Witiak DT, DeYoung JL, Lin AJ. Comparative kinetics of cytosine nucleosides. Influence of a 6-methyl substituent on degradation rates and pathways in aqueous buffers. J Med Chem. 1972 Dec; 15(12):1207-14. PMID: 4635962.
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    40. Notari RE, Chin ML, Wittebort R. Arabinosylcytosine stability in aqueous solutions: pH profile and shelflife predictions. J Pharm Sci. 1972 Aug; 61(8):1189-96. PMID: 5050364.
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    41. Notari RE, Baker T. Hydroxamic acids. IV. Hydroxide effect in hydroxylaminolysis of ethyl acetate. J Pharm Sci. 1972 Feb; 61(2):244-8. PMID: 5059791.
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    42. Notari RE, DeYoung JL, Reuning RH. Effect of parallel first-order loss from site of administration on calculated values for absorption rate constants. J Pharm Sci. 1972 Jan; 61(1):135-8. PMID: 5058633.
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    43. Notari RE, Chin ML, Cardoni A. Intermolecular and intramolecular catalysis in deamination of cytosine nucleosides. J Pharm Sci. 1970 Jan; 59(1):27-32. PMID: 5411321.
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    44. Notari RE, Caiola SM. Catalysis of streptovitacin A dehydration: kinetics and mechanisms. J Pharm Sci. 1969 Oct; 58(10):1203-8. PMID: 5349103.
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    45. Notari RE, Chin ML, Cardoni A. Intramolecular participation in the hydrolytic deamination of 1-beta-D-arabinosylcytosine. Tetrahedron Lett. 1969 Sep; (40):3499-502. PMID: 5820945.
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    46. Notari RE, Munson JW. Hydroxamic acids. I. Factors affecting the stability of the hydroxamic acid-iron complex. J Pharm Sci. 1969 Sep; 58(9):1060-4. PMID: 5346065.
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    47. Notari RE. Hydroxamic acids. II. Kinetics and mechanisms of hydroxyaminolysis of succinimide. J Pharm Sci. 1969 Sep; 58(9):1064-8. PMID: 5346066.
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    48. Notari RE. Hydroxamic acids. 3. Kinetics of acetohydroxamic acid formation from ethyl acetate. J Pharm Sci. 1969 Sep; 58(9):1069-73. PMID: 5346067.
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    49. Notari RE. A mechanism for the hydrolytic deamination of cytosine arabinoside in aqueous buffer. J Pharm Sci. 1967 Jul; 56(7):804-9. PMID: 6034820.
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    50. Garrett ER, Notari RE. Cycloheximide transformations. I. Kinetics and mechanisms in aqueous acid. J Org Chem. 1966 Feb; 31(2):425-34. PMID: 5902474.
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    51. Notari RE, Sokoloski TD. Kinetics of calcium carbonate neutralization. First-order case of the cube-root law. J Pharm Sci. 1965 Oct; 54(10):1500-4. PMID: 5883225.
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    52. Garrett ER, Notari RE. Determination of cycloheximide and its degradiation products alone and in mixtures. J Pharm Sci. 1965 Apr; 54(4):561-4. PMID: 5842339.
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    53. GARRETT ER, NOTARI RE. CYCOLHEXIMIDE TRANSFORMATIONS. II. KINETICS AND STABILITY IN A PHARMACEUTICALLY USEFUL PH RANGE. J Pharm Sci. 1965 Feb; 54:209-15. PMID: 14301000.
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