Perry V. Halushka

TitleDean Emeritus, College of Graduate Studies
InstitutionMedical University of South Carolina
DepartmentCell and Molecular Pharmacology and Experimental Therapeutics
AddressP.O. Box MSC 501
BE 101
68 President St.
Phone843-876-2405
Fax843-876-2416
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    Collapse Biography 
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    1984 - 1989Burroughs Wellcome Scholar in Clinical Pharmacology, musc
    1995Association of American Physicians

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    Perry V. Halushka, M.D., Ph.D. is a Distinguished University Professor of Cell and Molecular Pharmacology, the Program Director of Medical Scientist Training Program, and dean emeritus of the College of Graduate Studies. He received his Ph.D. degree in 1967 and M.D. degree in 1970 from the University of Chicago. After internship and residency in Internal Medicine at Grady Memorial Hospital, he spent two years at the NIH, Experimental Therapeutics Branch. In 1974, he joined the faculty of the Medical University of South Carolina.

    Dr. Halushka¹s research has revolved around molecular characterizations and regulation of Thromboxane A2 receptors in health and disease. "The long term objective of our research program is to determine the role of thromboxane A2 receptors in disease processes with a particular emphasis in cancer. In collaboration with Drs. Omar Moussa and Dennis Watson we have found that there is an over-expression of the beta isoform of thromboxane A2 receptors in bladder cancer tissue and cell lines. The over-expression is associated with a poorer prognosis in patients with bladder cancer. Current studies are focused on determining the mechanisms for: 1) the over-expression of the receptors and 2) the signaling pathways involved in the oncogenic effects. The observations made in these studies may have wider applicability to other cancers."
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    Molecular Characterization, Regulation of Thromboxane A2 Receptors in Health and Disease

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Li P, Wu Y, Goodwin AJ, Halushka PV, Wilson CL, Schnapp LM, Fan H. Generation of a new immortalized human lung pericyte cell line: a promising tool for human lung pericyte studies. Lab Invest. 2021 May; 101(5):625-635. PMID: 33446892.
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    2. Halushka P, Loucks TL, Paranal R, Harvey J, Briggman K, Lee-Chavarria D, Feghali-Bostwick C. The translational sciences clinic: From bench to bedside. J Clin Transl Sci. 2020 Aug 25; 5(1):e36. PMID: 33948258.
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    3. Wu Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Zingarelli B, Fan H. miR-145a Regulation of Pericyte Dysfunction in a Murine Model of Sepsis. J Infect Dis. 2020 08 17; 222(6):1037-1045. PMID: 32285112.
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    4. Currie MG, Zimmer DP, Halushka PV. An Impaired Natriuretic Peptide Hormone System May Play a Role in COVID-19 Severity in Vulnerable Populations. FASEB Bioadv. 2020 Aug 14. PMID: 32838215.
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    5. Goodwin AJ, Li P, Halushka PV, Cook JA, Sumal AS, Fan H. Circulating miRNA 887 is differentially expressed in ARDS and modulates endothelial function. Am J Physiol Lung Cell Mol Physiol. 2020 06 01; 318(6):L1261-L1269. PMID: 32321279.
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    6. Bonilha H, Hyer M, Krug E, Mauldin M, Edlund B, Martin-Harris B, Halushka P, McGinty J, Sullivan J, Brady K, Ranwala D, Hermayer K, Harvey J, Paranal R, Gough J, Silvestri G, Chimowitz M. An institution-wide faculty mentoring program at an academic health center with 6-year prospective outcome data - ADDENDUM. J Clin Transl Sci. 2020 Mar 31; 4(4):370. PMID: 33244421.
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    7. Bonilha H, Hyer M, Krug E, Mauldin M, Edlund B, Martin-Harris B, Halushka P, McGinty J, Sullivan J, Brady K, Ranwala D, Hermayer K, Harvey J, Paranal R, Gough J, Silvestri G, Chimowitz M. An institution-wide faculty mentoring program at an academic health center with 6-year prospective outcome data. J Clin Transl Sci. 2019 Dec; 3(6):308-315. PMID: 31827904.
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    8. Feghali-Bostwick C, Harvey J, Hasseler C, Lee-Chavarria D, Halushka P. A team-based translational journal club: Understanding the translational research highway. J Clin Transl Sci. 2019 Dec; 3(6):291-294. PMID: 31827901.
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    9. Zhou Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Chang E, Zingarelli B, Fan H. Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury. Crit Care. 2019 02 13; 23(1):44. PMID: 30760290.
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    10. Li P, Goodwin AJ, Cook JA, Halushka PV, Zhang XK, Fan H. Fli-1 transcription factor regulates the expression of caspase-1 in lung pericytes. Mol Immunol. 2019 04; 108:1-7. PMID: 30739075.
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    11. Jones Buie JN, Zhou Y, Goodwin AJ, Cook JA, Vournakis J, Demcheva M, Broome AM, Dixit S, Halushka PV, Fan H. Application of Deacetylated Poly-N-Acetyl Glucosamine Nanoparticles for the Delivery of miR-126 for the Treatment of Cecal Ligation and Puncture-Induced Sepsis. Inflammation. 2019 Feb; 42(1):170-184. PMID: 30244405.
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    12. Li P, Zhou Y, Goodwin AJ, Cook JA, Halushka PV, Zhang XK, Wilson CL, Schnapp LM, Zingarelli B, Fan H. Fli-1 Governs Pericyte Dysfunction in a Murine Model of Sepsis. J Infect Dis. 2018 11 05; 218(12):1995-2005. PMID: 30053030.
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    13. Halushka PV, Goodwin AJ, Halushka MK. Opportunities for microRNAs in the Crowded Field of Cardiovascular Biomarkers. Annu Rev Pathol. 2019 01 24; 14:211-238. PMID: 30332561.
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    14. Zhou Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Chang E, Fan H. Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis. Mol Ther. 2018 05 02; 26(5):1375-1384. PMID: 29599080.
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    15. Ranwala D, Alberg AJ, Brady KT, Obeid JS, Davis R, Halushka PV. Scientific retreats with 'speed dating': networking to stimulate new interdisciplinary translational research collaborations and team science. J Investig Med. 2017 02; 65(2):382-390. PMID: 27807146.
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    16. Jones Buie JN, Goodwin AJ, Cook JA, Halushka PV, Fan H. The role of miRNAs in cardiovascular disease risk factors. Atherosclerosis. 2016 11; 254:271-281. PMID: 27693002.
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    17. Guo C, Goodwin A, Buie JNJ, Cook J, Halushka P, Argraves K, Zingarelli B, Zhang X, Wang L, Fan H. A Stromal Cell-Derived Factor 1a Analogue Improves Endothelial Cell Function in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome. Mol Med. 2016 Sep; 22:115-123. PMID: 27031787.
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    18. Goodwin AJ, Guo C, Cook JA, Wolf B, Halushka PV, Fan H. Plasma levels of microRNA are altered with the development of shock in human sepsis: an observational study. Crit Care. 2015 Dec 18; 19:440. PMID: 26683209.
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    19. Smolka AJ, Halushka PV, Garrett-Mayer E. The faculty costs to educate a biomedical sciences graduate student. CBE Life Sci Educ. 2015 Mar 02; 14(1):ar3. PMID: 25673355.
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    20. Sobolesky PM, Halushka PV, Garrett-Mayer E, Smith MT, Moussa O. Regulation of the tumor suppressor FOXO3 by the thromboxane-A2 receptors in urothelial cancer. PLoS One. 2014; 9(9):e107530. PMID: 25202904.
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    21. Guan S, Guo C, Zingarelli B, Wang L, Halushka PV, Cook JA, Fan H. Combined treatment with a CXCL12 analogue and antibiotics improves survival and neutrophil recruitment and function in murine sepsis. Immunology. 2014 Sep 08. PMID: 25201453.
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    22. Fan H, Goodwin AJ, Chang E, Zingarelli B, Borg K, Guan S, Halushka PV, Cook JA. Endothelial progenitor cells and a stromal cell-derived factor-1a analogue synergistically improve survival in sepsis. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1509-19. PMID: 24707934.
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    23. Manevich Y, Hutchens S, Halushka PV, Tew KD, Townsend DM, Jauch EC, Borg K. Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome. Free Radic Biol Med. 2014 Jul; 72:210-21. PMID: 24726861.
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    24. Li P, Neubig RR, Zingarelli B, Borg K, Halushka PV, Cook JA, Fan H. Toll-like receptor-induced inflammatory cytokines are suppressed by gain of function or overexpression of Ga(i2) protein. Inflammation. 2012 Oct; 35(5):1611-7. PMID: 22581266.
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    25. Fan H, Wong D, Ashton SH, Borg KT, Halushka PV, Cook JA. Beneficial effect of a CXCR4 agonist in murine models of systemic inflammation. Inflammation. 2012 Feb; 35(1):130-7. PMID: 21274742.
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    26. Moussa O, Ciupek A, Watson DK, Halushka PV. Urinary thromboxane B2 and thromboxane receptors in bladder cancer: opportunity for detection and monitoring. Prostaglandins Other Lipid Mediat. 2011 Nov; 96(1-4):41-4. PMID: 21983220.
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    27. Li P, Cook JA, Gilkeson GS, Luttrell LM, Wang L, Borg KT, Halushka PV, Fan H. Increased expression of beta-arrestin 1 and 2 in murine models of rheumatoid arthritis: isoform specific regulation of inflammation. Mol Immunol. 2011 Oct; 49(1-2):64-74. PMID: 21855149.
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    28. Oates JC, Halushka PV, Hutchison FN, Ruiz P, Gilkeson GS. Selective cyclooxygenase-2 inhibitor suppresses renal thromboxane production but not proliferative lesions in the MRL/lpr murine model of lupus nephritis. Am J Med Sci. 2011 Feb; 341(2):101-5. PMID: 20924284.
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    29. Fan H, Li P, Zingarelli B, Borg K, Halushka PV, Birnbaumer L, Cook JA. Heterotrimeric Ga(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis. Biochim Biophys Acta. 2011 Mar; 1813(3):466-72. PMID: 21255617.
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    30. Fan H, Bitto A, Zingarelli B, Luttrell LM, Borg K, Halushka PV, Cook JA. Beta-arrestin 2 negatively regulates sepsis-induced inflammation. Immunology. 2010 Jul; 130(3):344-51. PMID: 20465566.
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    31. Halushka PV, Krug EL. Is the training of biomedical scientists at a crossroads? Acad Med. 2009 Apr; 84(4):421-3. PMID: 19318769.
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    32. Fan H, Zingarelli B, Harris V, Tempel GE, Halushka PV, Cook JA. Lysophosphatidic acid inhibits bacterial endotoxin-induced pro-inflammatory response: potential anti-inflammatory signaling pathways. Mol Med. 2008 Jul-Aug; 14(7-8):422-8. PMID: 18431464.
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    33. Moussa O, Ashton AW, Fraig M, Garrett-Mayer E, Ghoneim MA, Halushka PV, Watson DK. Novel role of thromboxane receptors beta isoform in bladder cancer pathogenesis. Cancer Res. 2008 Jun 01; 68(11):4097-104. PMID: 18519668.
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    34. Basher F, Fan H, Zingarelli B, Borg KT, Luttrell LM, Tempel GE, Halushka PV, Cook JA. beta-Arrestin 2: a Negative Regulator of Inflammatory Responses in Polymorphonuclear Leukocytes. Int J Clin Exp Med. 2008; 1(1):32-41. PMID: 19079685.
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    35. Moussa O, Riker JM, Klein J, Fraig M, Halushka PV, Watson DK. Inhibition of thromboxane synthase activity modulates bladder cancer cell responses to chemotherapeutic agents. Oncogene. 2008 Jan 03; 27(1):55-62. PMID: 17603559.
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    36. Fan H, Williams DL, Zingarelli B, Breuel KF, Teti G, Tempel GE, Spicher K, Boulay G, Birnbaumer L, Halushka PV, Cook JA. Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins. Immunology. 2007 Sep; 122(1):116-23. PMID: 17484771.
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    37. Fan H, Luttrell LM, Tempel GE, Senn JJ, Halushka PV, Cook JA. Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression. Mol Immunol. 2007 May; 44(12):3092-9. PMID: 17418896.
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    38. Fan H, Williams DL, Breuel KF, Zingarelli B, Teti G, Tempel GE, Halushka PV, Cook JA. Gi proteins regulate lipopolysaccharide and Staphylococcus aureus induced cytokine production but not (1--> 3)-beta-D-glucan induced cytokine suppression. Front Biosci. 2006 Sep 01; 11:2264-74. PMID: 16720313.
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    39. Fan H, Williams DL, Zingarelli B, Breuel KF, Teti G, Tempel GE, Spicher K, Boulay G, Birnbaumer L, Halushka PV, Cook JA. Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins. Biochim Biophys Acta. 2006 Oct; 1763(10):1051-8. PMID: 16962188.
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    40. Peck OM, Zingarelli B, Fan H, Teti G, Tempel G, Halushka PV, Cook JA. The phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharide. Shock. 2006 Jul; 26(1):31-6. PMID: 16783195.
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    41. Halushka MK, Halushka PV. Toward individualized analgesic therapy: functional cyclooxygenase 1 and 2 haplotypes. Clin Pharmacol Ther. 2006 May; 79(5):404-6. PMID: 16678542.
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    42. Moussa O, Yordy JS, Abol-Enein H, Sinha D, Bissada NK, Halushka PV, Ghoneim MA, Watson DK. Prognostic and functional significance of thromboxane synthase gene overexpression in invasive bladder cancer. Cancer Res. 2005 Dec 15; 65(24):11581-7. PMID: 16357168.
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    43. Ajayi AA, Halushka PV. Castration reduces platelet thromboxane A2 receptor density and aggregability. QJM. 2005 May; 98(5):349-56. PMID: 15820970.
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    44. Fan H, Zingarelli B, Peck OM, Teti G, Tempel GE, Halushka PV, Spicher K, Boulay G, Birnbaumer L, Cook JA. Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins. . 2005 Aug; 289(2):C293-301. PMID: 15788486.
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    45. Malcolm R, LaRowe S, Cochran K, Moak D, Herron J, Brady K, Hedden S, Woolson R, Halushka P. A controlled trial of amlodipine for cocaine dependence: a negative report. J Subst Abuse Treat. 2005 Mar; 28(2):197-204. PMID: 15780550.
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    46. Fan H, Peck OM, Tempel GE, Halushka PV, Cook JA. Toll-like receptor 4 coupled GI protein signaling pathways regulate extracellular signal-regulated kinase phosphorylation and AP-1 activation independent of NFkappaB activation. Shock. 2004 Jul; 22(1):57-62. PMID: 15201703.
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    47. Peck OM, Fan H, Tempel GE, Teti G, Halushka PV, Cook JA. Staphylococcus aureus and lipopolysaccharide induce homologous tolerance but heterologous priming: role of interferon-gamma. Shock. 2004 Mar; 21(3):254-60. PMID: 14770039.
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    48. Taylor DM, Halushka PV, Meier GP. Hydrogen bond interactions of a series of N-substituted TXA2 receptor antagonists. Eur J Med Chem. 2003 Nov-Dec; 38(11-12):1015-24. PMID: 14642334.
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    49. Qiao N, Reynaud D, Demin P, Halushka PV, Pace-Asciak CR. The thromboxane receptor antagonist PBT-3, a hepoxilin stable analog, selectively antagonizes the TPalpha isoform in transfected COS-7 cells. J Pharmacol Exp Ther. 2003 Dec; 307(3):1142-7. PMID: 14560042.
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    50. Guyton K, Zingarelli B, Ashton S, Teti G, Tempel G, Reilly C, Gilkeson G, Halushka P, Cook J. Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli. Shock. 2003 Jul; 20(1):56-62. PMID: 12813370.
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    51. Fan H, Teti G, Ashton S, Guyton K, Tempel GE, Halushka PV, Cook JA. Involvement of G(i) proteins and Src tyrosine kinase in TNFalpha production induced by lipopolysaccharide, group B Streptococci and Staphylococcus aureus. Cytokine. 2003 Jun 07; 22(5):126-33. PMID: 12842760.
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    52. Halushka MK, Walker LP, Halushka PV. Genetic variation in cyclooxygenase 1: effects on response to aspirin. Clin Pharmacol Ther. 2003 Jan; 73(1):122-30. PMID: 12545150.
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    53. Gale DD, Hofer P, Spina D, Seeds EA, Banner KH, Harrison S, Douglas G, Matsumoto T, Page CP, Wong RH, Jordan S, Smith F, Banik N, Halushka PV, Cavalla D, Rotshteyn Y, Kyle DJ, Burch RM, Chasin M. Pharmacology of a new cyclic nucleotide phosphodiesterase type 4 inhibitor, V11294. Pulm Pharmacol Ther. 2003; 16(2):97-104. PMID: 12670778.
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    54. Malcolm R, Liao J, Michel M, Cochran K, Pye W, Yeager D, Halushka PV. Amlodipine reduces blood pressure and headache frequency in cocaine-dependent outpatients. J Psychoactive Drugs. 2002 Oct-Dec; 34(4):415-9. PMID: 12562110.
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    55. Halushka MK, Halushka PV. Why are some individuals resistant to the cardioprotective effects of aspirin? Could it be thromboxane A2? Circulation. 2002 Apr 09; 105(14):1620-2. PMID: 11940535.
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    56. Ferlito M, Romanenko OG, Guyton K, Ashton S, Squadrito F, Halushka PV, Cook JA. Implication of Galpha i proteins and Src tyrosine kinases in endotoxin-induced signal transduction events and mediator production. J Endotoxin Res. 2002; 8(6):427-35. PMID: 12701623.
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    57. Tempel GE, Brown AN, Morinelli TA, Halushka PV, Cook JA. Changes in vascular responsiveness to a thromboxane mimetic in endotoxin tolerance. Shock. 2001 Nov; 16(5):389-92. PMID: 11699079.
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    58. Ferlito M, Romanenko OG, Ashton S, Squadrito F, Halushka PV, Cook JA. Effect of cross-tolerance between endotoxin and TNF-alpha or IL-1beta on cellular signaling and mediator production. J Leukoc Biol. 2001 Nov; 70(5):821-9. PMID: 11698503.
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    59. Minshall RD, Pavcnik D, Halushka PV, Hermsmeyer K. Progesterone regulation of vascular thromboxane A(2) receptors in rhesus monkeys. . 2001 Oct; 281(4):H1498-507. PMID: 11557538.
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    60. Walle T, Walle UK, Halushka PV. Carbon dioxide is the major metabolite of quercetin in humans. J Nutr. 2001 Oct; 131(10):2648-52. PMID: 11584085.
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    61. Ferlito M, Squadrito F, Halushka PV, Cook JA. Signal transduction events in Chinese hamster ovary cells expressing human CD14; effect of endotoxin desensitization. Shock. 2001 Apr; 15(4):291-6. PMID: 11303728.
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    62. Guyton K, Bond R, Reilly C, Gilkeson G, Halushka P, Cook J. Differential effects of 15-deoxy-delta(12,14)-prostaglandin J2 and a peroxisome proliferator-activated receptor gamma agonist on macrophage activation. J Leukoc Biol. 2001 Apr; 69(4):631-8. PMID: 11310850.
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    63. Reilly CM, Oates JC, Sudian J, Crosby MB, Halushka PV, Gilkeson GS. Prostaglandin J(2) inhibition of mesangial cell iNOS expression. Clin Immunol. 2001 Mar; 98(3):337-45. PMID: 11237557.
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    64. Walle T, Otake Y, Brubaker JA, Walle UK, Halushka PV. Disposition and metabolism of the flavonoid chrysin in normal volunteers. Br J Clin Pharmacol. 2001 Feb; 51(2):143-6. PMID: 11259985.
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    65. Fernando LP, Fernando AN, Ferlito M, Halushka PV, Cook JA. Suppression of Cox-2 and TNF-alpha mRNA in endotoxin tolerance: effect of cycloheximide, antinomycin D, and okadaic acid. Shock. 2000 Aug; 14(2):128-33. PMID: 10947155.
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    66. Halushka PV. Thromboxane A(2) receptors: where have you gone? Prostaglandins Other Lipid Mediat. 2000 Mar; 60(4-6):175-89. PMID: 10751648.
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    67. Reilly CM, Oates JC, Cook JA, Morrow JD, Halushka PV, Gilkeson GS. Inhibition of mesangial cell nitric oxide in MRL/lpr mice by prostaglandin J2 and proliferator activation receptor-gamma agonists. J Immunol. 2000 Feb 01; 164(3):1498-504. PMID: 10640767.
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    68. Becker KP, Garnovskaya M, Gettys T, Halushka PV. Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling. Biochim Biophys Acta. 1999 Jul 08; 1450(3):288-96. PMID: 10395940.
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    69. Fernando LP, Makhlouf M, Fernando AN, Ashton S, Halushka PV, Cook JA. Tolerance to LPS decreases macrophage G protein content. Shock. 1999 May; 11(5):330-5. PMID: 10353538.
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    70. Pawate S, Schey KL, Meier GP, Ullian ME, Mais DE, Halushka PV. Expression, characterization, and purification of C-terminally hexahistidine-tagged thromboxane A2 receptors. J Biol Chem. 1998 Aug 28; 273(35):22753-60. PMID: 9712907.
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    71. Becker KP, Ullian M, Halushka PV. Cloning and characterization of an endogenous COS-7 cell thromboxane A2 receptor. Biochim Biophys Acta. 1998 May 27; 1403(1):109-14. PMID: 9622606.
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    72. Makhlouf MA, Fernando LP, Gettys TW, Halushka PV, Cook JA. Increased prostacyclin and PGE2 stimulated cAMP production by macrophages from endotoxin-tolerant rats. Am J Physiol. 1998 05; 274(5):C1238-44. PMID: 9612210.
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    73. Durando M, Fernando L, Ashton S, Halushka P, Cook J. Suppressed thromboxane production in endotoxin-desensitized THP-1 cells is not a result of decreased prostaglandin H synthase activity. Shock. 1998 May; 9(5):359-63. PMID: 9617886.
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    74. Wang GR, Zhu Y, Halushka PV, Lincoln TM, Mendelsohn ME. Mechanism of platelet inhibition by nitric oxide: in vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):4888-93. PMID: 9560198.
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    75. Makhlouf M, Zingarelli B, Halushka PV, Cook JA. Endotoxin tolerance alters macrophage membrane regulatory G proteins. Prog Clin Biol Res. 1998; 397:217-26. PMID: 9575562.
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    76. Higashiura K, Mathur RS, Halushka PV. Gender-related differences in androgen regulation of thromboxane A2 receptors in rat aortic smooth-muscle cells. J Cardiovasc Pharmacol. 1997 Mar; 29(3):311-5. PMID: 9125667.
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    77. Brothers TE, Robison JG, Elliott BM, Boggs JM, Halushka PV. Thromboxane A2 receptor density increases during chronic exposure to thromboxane A2 receptor antagonists after porcine carotid bypass. Cardiovasc Surg. 1997 Feb; 5(1):92-8. PMID: 9158129.
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    78. Schrör K, Davis-Bruno K, Halushka PV. Modification on ligand binding to TXA2/PGH2 receptors by diethylpyrocarbonate. Adv Exp Med Biol. 1997; 400A:235-40. PMID: 9547563.
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    79. Higashiura K, Blaney B, Morgan E, Mathur RS, Halushka PV. Inhibition of testosterone 5 alpha-reductase: evidence for tissue-specific regulation of thromboxane A2 receptors. J Pharmacol Exp Ther. 1996 Dec; 279(3):1386-91. PMID: 8968363.
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    80. Makhlouf M, Ashton SH, Hildebrandt J, Mehta N, Gettys TW, Halushka PV, Cook JA. Alterations in macrophage G proteins are associated with endotoxin tolerance. Biochim Biophys Acta. 1996 Jun 13; 1312(2):163-8. PMID: 8672540.
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    81. Allan CJ, Higashiura K, Martin M, Morinelli TA, Kurtz DT, Geoffroy O, Meier GP, Gettys TW, Halushka PV. Characterization of the cloned HEL cell thromboxane A2 receptor: evidence that the affinity state can be altered by G alpha 13 and G alpha q. J Pharmacol Exp Ther. 1996 May; 277(2):1132-9. PMID: 8627525.
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    82. Paul RV, Saxenhofer H, Wackym PS, Halushka PV. Stimulation of rat mesangial cell thromboxane A2 receptors inhibits particulate but not soluble guanylyl cyclase. Am J Physiol. 1996 Jan; 270(1 Pt 2):F31-8. PMID: 8769820.
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    83. Zucker TP, Higashiura K, Mathur RS, Halushka PV. Androstenedione increases thromboxane A2 receptors in human erythroleukemia cells. Life Sci. 1996; 58(8):683-90. PMID: 8594318.
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    84. Wagner RS, Halushka PV, Cook JA. Activation of thromboxane A2 receptors alters lipopolysaccharide-induced adherence of THP-1 cells. Shock. 1996 Jan; 5(1):41-6. PMID: 8821102.
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    85. Halushka PV, Allan CJ, Davis-Bruno KL. Thromboxane A2 receptors. J Lipid Mediat Cell Signal. 1995 Oct; 12(2-3):361-78. PMID: 8777579.
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    86. Ajayi AA, Mathur R, Halushka PV. Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses. Circulation. 1995 Jun 01; 91(11):2742-7. PMID: 7758179.
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    87. Schrör K, Davis-Bruno K, Halushka PV. Inhibition of ligand binding to thromboxane A2/prostaglandin H2 receptors by diethylpyrocarbonate. Protection by receptor ligands and reversal by hydroxylamine. Biochem Pharmacol. 1995 Mar 30; 49(7):921-7. PMID: 7741764.
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    88. Matsuda K, Mathur RS, Ullian ME, Halushka PV. Sex steroid regulation of thromboxane A2 receptors in cultured rat aortic smooth muscle cells. Prostaglandins. 1995 Mar; 49(3):183-96. PMID: 7652187.
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    89. Zingarelli B, Halushka PV, Caputi AP, Cook JA. Increased nitric oxide synthesis during the development of endotoxin tolerance. Shock. 1995 Feb; 3(2):102-8. PMID: 7749936.
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    90. Zingarelli B, Chen H, Caputi AP, Halushka PV, Cook JA. Reorientation of macrophage mediator production in endotoxin tolerance. Prog Clin Biol Res. 1995; 392:529-37. PMID: 8524961.
      Citations:    
    91. Zucker TP, Grosser T, Morinelli T, Halushka PV, Sachinidis A, Vetter H, Schrör K. Potentiation of PDGF-induced growth responses in coronary artery smooth muscle cells by thromboxane. Agents Actions Suppl. 1995; 45:53-8. PMID: 7717201.
      Citations:    
    92. Ajayi AA, Matsuda K, Schrör K, Masuda A, Mathur R, Halushka PV. Androgen regulation of thromboxane A2 receptors. Adv Prostaglandin Thromboxane Leukot Res. 1995; 23:251-3. PMID: 7732846.
      Citations:    
    93. Halushka PV, Matsuda K, Masuda A, Ruff A, Morinelli TA, Mathur RS. Testosterone regulation of platelet and vascular thromboxane A2 receptors. Agents Actions Suppl. 1995; 45:19-26. PMID: 7717179.
      Citations:    
    94. Geisel J, Cook JA, Ashton SH, Wise WC, Halushka PV. Endotoxin tolerance is associated with decreased prostaglandin H synthases-1 and -2. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1067-72. PMID: 7943269.
      Citations:    
    95. Matsuda K, Ruff A, Morinelli TA, Mathur RS, Halushka PV. Testosterone increases thromboxane A2 receptor density and responsiveness in rat aortas and platelets. Am J Physiol. 1994 Sep; 267(3 Pt 2):H887-93. PMID: 8092292.
      Citations:    
    96. Yin K, Halushka PV, Yan YT, Wong PY. Antiaggregatory activity of 8-epi-prostaglandin F2 alpha and other F-series prostanoids and their binding to thromboxane A2/prostaglandin H2 receptors in human platelets. J Pharmacol Exp Ther. 1994 Sep; 270(3):1192-6. PMID: 7932171.
      Citations:    
    97. Allan CJ, Halushka PV. Characterization of human peripheral blood monocyte thromboxane A2 receptors. J Pharmacol Exp Ther. 1994 Aug; 270(2):446-52. PMID: 8071836.
      Citations:    
    98. Buzzard CJ, Pfister SL, Halushka PV, Campbell WB. Decrease in vascular TxA2 receptors in a subgroup of rabbits unresponsive to a TxA2 mimetic. Am J Physiol. 1994 Jun; 266(6 Pt 2):H2320-6. PMID: 8023992.
      Citations:    
    99. Chen H, Halushka PV, Cook JA. Endotoxin tolerance: effects on lethality and macrophage thromboxane (B2) and interleukin 6 production. Shock. 1994 May; 1(5):366-71. PMID: 7743340.
      Citations:    
    100. Okwu AK, Mais DE, Halushka PV. Agonist-induced phosphorylation of human platelet TXA2/PGH2 receptors. Biochim Biophys Acta. 1994 Mar 10; 1221(1):83-8. PMID: 8130280.
      Citations:    
    101. Schrör K, Morinelli TA, Masuda A, Matsuda K, Mathur RS, Halushka PV. Testosterone treatment enhances thromboxane A2 mimetic induced coronary artery vasoconstriction in guinea pigs. Eur J Clin Invest. 1994 Feb; 24 Suppl 1:50-2. PMID: 8013532.
      Citations:    
    102. Rinder CA, Halushka PV, Sens MA, Ploth DW. Thromboxane A2 receptor blockade improves renal function and histopathology in the post-obstructive kidney. Kidney Int. 1994 Jan; 45(1):185-92. PMID: 8127008.
      Citations:    
    103. Halushka PV, Masuda A, Matsuda K. The Gordon Wilson Lecture. Regulation of thromboxane A2 receptors by testosterone: implications for steroid abuse and cardiovascular disease. Trans Am Clin Climatol Assoc. 1994; 105:95-103. PMID: 7974982.
      Citations:    
    104. Matsuda K, Mathur RS, Duzic E, Halushka PV. Androgen regulation of thromboxane A2/prostaglandin H2 receptor expression in human erythroleukemia cells. Am J Physiol. 1993 Dec; 265(6 Pt 1):E928-34. PMID: 8279549.
      Citations:    
    105. Liel N, Nathan I, Yermiyahu T, Zolotov Z, Lieberman JR, Dvilansky A, Halushka PV. Increased platelet thromboxane A2/prostaglandin H2 receptors in patients with pregnancy induced hypertension. Thromb Res. 1993 May 01; 70(3):205-10. PMID: 8327985.
      Citations:    
    106. Morinelli TA, Tempel GE, Jaffa AA, Silva RH, Naka M, Folger W, Halushka PV. Thromboxane A2/prostaglandin H2 receptors in streptozotocin-induced diabetes: effects of insulin therapy in the rat. Prostaglandins. 1993 May; 45(5):427-38. PMID: 8321912.
      Citations:    
    107. Matera G, Cook JA, Geisel J, Ashton SH, Wise WC, Focá A, Berkowitz BA, Halushka PV. Effects of two magainin peptides on eicosanoid release from rat peritoneal macrophages. Antimicrob Agents Chemother. 1993 Mar; 37(3):393-7. PMID: 8460910.
      Citations:    
    108. Simmons TR, Cook JA, Moore JN, Halushka PV. Thromboxane A2 receptors in equine monocytes: identification of a new subclass of TXA2 receptors. J Leukoc Biol. 1993 Feb; 53(2):173-8. PMID: 8383167.
      Citations:    
    109. Cook JA, Geisel J, Halushka PV, Reines HD. Prostaglandins, thromboxanes, leukotrienes, and cytochrome P-450 metabolites of arachidonic acid. New Horiz. 1993 Feb; 1(1):60-9. PMID: 7922394.
      Citations:    
    110. Folger WH, Halushka PV, Wilcox CS, Guzman NJ. Characterization of rat glomerular thromboxane A2 receptors: comparison to rat platelets. Eur J Pharmacol. 1992 Sep 01; 227(1):71-8. PMID: 1426024.
      Citations:    
    111. Coffee KA, Halushka PV, Ashton SH, Tempel GE, Wise WC, Cook JA. Endotoxin tolerance is associated with altered GTP-binding protein function. J Appl Physiol (1985). 1992 Sep; 73(3):1008-13. PMID: 1400011.
      Citations:    
    112. Naka M, Mais DE, Morinelli TA, Hamanaka N, Oatis JE, Halushka PV. 7-[(1R,2S,3S,5R)-6,6-dimethyl-3-(4- iodobenzenesulfonylamino)bicyclo[3.1.1]hept-2-yl]-5(Z)-heptenoic acid: a novel high-affinity radiolabeled antagonist for platelet thromboxane A2/prostaglandin H2 receptors. J Pharmacol Exp Ther. 1992 Aug; 262(2):632-7. PMID: 1386885.
      Citations:    
    113. Okwu AK, Ullian ME, Halushka PV. Homologous desensitization of human platelet thromboxane A2/prostaglandin H2 receptors. J Pharmacol Exp Ther. 1992 Jul; 262(1):238-45. PMID: 1378092.
      Citations:    
    114. Bernard GR, Reines HD, Halushka PV, Higgins SB, Metz CA, Swindell BB, Wright PE, Watts FL, Vrbanac JJ. Prostacyclin and thromboxane A2 formation is increased in human sepsis syndrome. Effects of cyclooxygenase inhibition. Am Rev Respir Dis. 1991 Nov; 144(5):1095-101. PMID: 1952438.
      Citations:    
    115. Masuda A, Mathur R, Halushka PV. Testosterone increases thromboxane A2 receptors in cultured rat aortic smooth muscle cells. Circ Res. 1991 Sep; 69(3):638-43. PMID: 1831411.
      Citations:    
    116. Geisel J, Cook JA, Coffee KA, Wise WC, Halushka PV. Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation. Biochim Biophys Acta. 1991 Aug 20; 1085(1):15-20. PMID: 1909897.
      Citations:    
    117. Li EJ, Cook JA, Wise WC, Jackson WT, Halushka PV. Effect of LTB4 receptor antagonists in endotoxic shock in the rat. Circ Shock. 1991 Aug; 34(4):385-92. PMID: 1663429.
      Citations:    
    118. Mayeux PR, Morinelli TA, Williams TC, Hazard ES, Mais DE, Oatis JE, Baron DA, Halushka PV. Differential effect of pH on thromboxane A2/prostaglandin H2 receptor agonist and antagonist binding in human platelets. J Biol Chem. 1991 Jul 25; 266(21):13752-8. PMID: 1830308.
      Citations:    
    119. Masuda A, Mais DE, Oatis JE, Halushka PV. Platelet and vascular thromboxane A2/prostaglandin H2 receptors. Evidence for different subclasses in the rat. Biochem Pharmacol. 1991 Jul 15; 42(3):537-44. PMID: 1830482.
      Citations:    
    120. Li EJ, Cook JA, Ashton S, Wise WC, Halushka PV. Effect of the LTD4 receptor antagonist LY203647 on endotoxic shock sequelae in the rat. Eur J Pharmacol. 1991 Jun 25; 199(2):221-5. PMID: 1954979.
      Citations:    
    121. Morinelli TA, Halushka PV. Thromboxane-A(2)/prostaglandin-H(2) receptors Characterization and antagonism. Trends Cardiovasc Med. 1991 May-Jun; 1(4):157-61. PMID: 21239318.
      Citations:    
    122. Mais DE, Bowling NL, True TA, Naka M, Morinelli TA, Oatis JE, Hamanaka N, Halushka PV. Novel synthesis and biochemical properties of an [125I]-labeled photoaffinity probe for thromboxane A2/prostaglandin H2 receptors. J Med Chem. 1991 Apr; 34(4):1511-4. PMID: 1826745.
      Citations:    
    123. Mayeux PR, Mais DE, Halushka PV. Interactions of dihydropyridine Ca2+ channel agonists with the human platelet thromboxane A2/prostaglandin H2 receptor. Eur J Pharmacol. 1991 Jan 25; 206(1):15-21. PMID: 1712307.
      Citations:    
    124. Zellner JL, Cook JA, Reines HD, Smith EF, Kessler LD, Halushka PV. Effect of a LTD4 receptor antagonist in porcine septic shock. Eicosanoids. 1991; 4(3):169-75. PMID: 1663380.
      Citations:    
    125. Masuda A, Halushka PV. Thromboxane A2 receptors are influenced by cell density in cultured rat aortic smooth muscle cells. Life Sci. 1991; 48(25):2391-5. PMID: 1828517.
      Citations:    
    126. Moore JN, Cook JA, Henry MM, Jonsson HT, Spicer KM, Wise WC, Halushka PV. Effects of a linseed oil enriched diet on endotoxin-induced sequelae: differential in vitro and in vivo effects. Eicosanoids. 1991; 4(1):47-55. PMID: 2059458.
      Citations:    
    127. Morinelli TA, Naka M, Masuda A, Oatis JE, Okwu AK, Mais DE, Saussy DL, Halushka PV. Characterization of thromboxane A2/prostaglandin H2 receptors of various tissues using a new radioiodinated thromboxane A2/prostaglandin H2 mimetic, I-BOP. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21A:331-7. PMID: 1825565.
      Citations:    
    128. Coffee KA, Halushka PV, Wise WC, Tempel GE, Cook JA. Endotoxin tolerance differentially alters hemodynamic responses to a thromboxane A2 mimetic and phenylephrine. J Cardiovasc Pharmacol. 1991 Jan; 17(1):20-6. PMID: 1708052.
      Citations:    
    129. Sessa WC, Halushka PV, Okwu A, Nasjletti A. Characterization of the vascular thromboxane A2/prostaglandin endoperoxide receptor in rabbit aorta. Regulation by dexamethasone. Circ Res. 1990 Dec; 67(6):1562-9. PMID: 2147131.
      Citations:    
    130. Cook JA, Li EJ, Spicer KM, Wise WC, Halushka PV. Effect of leukotriene receptor antagonists on vascular permeability during endotoxic shock. Circ Shock. 1990 Nov; 32(3):209-18. PMID: 2175680.
      Citations:    
    131. Mais DE, Liel N, Halushka PV. Photoaffinity receptor antagonist for human platelet thromboxane A2/prostaglandin H2 receptors. Biochem Pharmacol. 1990 Oct 01; 40(7):1457-61. PMID: 2145838.
      Citations:    
    132. Coffee KA, Halushka PV, Wise WC, Cook JA. Altered responses to modulators of guanine nucleotide binding protein activity in endotoxin tolerance. Biochim Biophys Acta. 1990 Aug 17; 1035(2):201-5. PMID: 2118385.
      Citations:    
    133. Moore JN, Cook JA, Morris DD, Halushka PV, Wise WC. Endotoxin-induced procoagulant activity, eicosanoid synthesis, and tumor necrosis factor production by rat peritoneal macrophages: effect of endotoxin tolerance and glucan. Circ Shock. 1990 Jul; 31(3):281-95. PMID: 2113440.
      Citations:    
    134. Li EJ, Cook JA, Spicer KM, Wise WC, Rokach J, Halushka PV. Resistance of essential fatty acid-deficient rats to endotoxin-induced increases in vascular permeability. Circ Shock. 1990 Jun; 31(2):159-70. PMID: 2188748.
      Citations:    
    135. Nishimiya T, Daniell HB, Webb JG, Oatis J, Walle T, Gaffney TE, Halushka PV. Chronic treatment with propranolol enhances the synthesis of prostaglandins E2 and I2 by the aorta of spontaneously hypertensive rats. J Pharmacol Exp Ther. 1990 Apr; 253(1):207-13. PMID: 2109798.
      Citations:    
    136. Halushka PV, Morinelli TA, Mais DE. Radioligand binding assays for thromboxane A2/prostaglandin H2 receptors. Methods Enzymol. 1990; 187:397-405. PMID: 2146462.
      Citations:    
    137. Zellner JL, Cook JA, Reines DH, Wise WC, Smith EF, Kessler LD, Halushka PV. Hemodynamic effects of leukotriene (LT) D4 and a LTD4 receptor antagonist in the pig. Eicosanoids. 1990; 3(4):219-24. PMID: 1963540.
      Citations:    
    138. Dorn GW, Liel N, Trask JL, Mais DE, Assey ME, Halushka PV. Increased platelet thromboxane A2/prostaglandin H2 receptors in patients with acute myocardial infarction. Circulation. 1990 Jan; 81(1):212-8. PMID: 2137044.
      Citations:    
    139. Morinelli TA, Mais DE, Oatis JE, Crumbley AJ, Halushka PV. Characterization of thromboxane A2/prostaglandin H2 receptors in human vascular smooth muscle cells. Life Sci. 1990; 46(24):1765-72. PMID: 2141663.
      Citations:    
    140. Morinelli TA, Mais DE, Oatis JE, Mayeux PR, Okwu AK, Masuda A, Knapp DR, Halushka PV. I-BOP, the most potent radiolabelled agonist for the TXA2/PGH2 receptor. Adv Prostaglandin Thromboxane Leukot Res. 1990; 20:102-9. PMID: 2144685.
      Citations:    
    141. Morinelli TA, Oatis JE, Okwu AK, Mais DE, Mayeux PR, Masuda A, Knapp DR, Halushka PV. Characterization of an 125I-labeled thromboxane A2/prostaglandin H2 receptor agonist. J Pharmacol Exp Ther. 1989 Nov; 251(2):557-62. PMID: 2530338.
      Citations:    
    142. Heffner JE, Cook JA, Halushka PV. Human platelets modulate edema formation in isolated rabbit lungs. J Clin Invest. 1989 Sep; 84(3):757-64. PMID: 2527253.
      Citations:    
    143. Mayeux PR, Mais DE, Carr C, Halushka PV. Human erythroleukemia cells express functional thromboxane A2/prostaglandin H2 receptors. J Pharmacol Exp Ther. 1989 Sep; 250(3):923-7. PMID: 2528631.
      Citations:    
    144. Ball HA, Cook JA, Spicer KM, Wise WC, Halushka PV. Essential fatty acid-deficient rats are resistant to oleic acid-induced pulmonary injury. J Appl Physiol (1985). 1989 Aug; 67(2):811-6. PMID: 2551875.
      Citations:    
    145. Mais DE, Yoakim C, Guindon Y, Gillard JW, Rokach J, Halushka PV. Photoaffinity labelling of the human platelet thromboxane A2/prostaglandin H2 receptor. Biochim Biophys Acta. 1989 Jul 11; 1012(2):184-90. PMID: 2525928.
      Citations:    
    146. Morinelli TA, Okwu AK, Mais DE, Halushka PV, John V, Chen CK, Fried J. Difluorothromboxane A2 and stereoisomers: stable derivatives of thromboxane A2 with differential effects on platelets and blood vessels. Proc Natl Acad Sci U S A. 1989 Jul; 86(14):5600-4. PMID: 2748606.
      Citations:    
    147. Lee WM, Reines D, Watt GH, Cook JA, Wise WC, Halushka PV, Galbraith RM. Alterations in Gc levels and complexing in septic shock. Circ Shock. 1989 Jul; 28(3):249-55. PMID: 2766479.
      Citations:    
    148. Watt GH, Ashton SH, Cook JA, Wise WC, Halushka PV, Galbraith RM. Alterations in plasma levels and complexing of Gc (vitamin D-binding protein) in rats with endotoxic shock. Circ Shock. 1989 Jul; 28(3):279-91. PMID: 2766482.
      Citations:    
    149. Powers K, Fyfe DA, Taylor AB, Halushka PV, Crawford FA. Treatment of pulmonary vasospasm with prazosin after atrial septal defect closure in a child. J Thorac Cardiovasc Surg. 1989 May; 97(5):802-4. PMID: 2709872.
      Citations:    
    150. Rogers TS, Halushka PV, Wise WC, Cook JA. Arachidonic acid turnover in peritoneal macrophages is altered in endotoxin-tolerant rats. Biochim Biophys Acta. 1989 Feb 06; 1001(2):169-75. PMID: 2492824.
      Citations:    
    151. Mais DE, Halushka PV. Photoaffinity labelling and isoelectric focusing of the human platelet thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor. Adv Prostaglandin Thromboxane Leukot Res. 1989; 19:168-71. PMID: 2526465.
      Citations:    
    152. Halushka PV. Pharmacology of thromboxane A2 receptor antagonists. Z Kardiol. 1989; 78 Suppl 3:42-7. PMID: 2530712.
      Citations:    
    153. Halushka PV, Mais DE, Mayeux PR, Morinelli TA. Thromboxane, prostaglandin and leukotriene receptors. Annu Rev Pharmacol Toxicol. 1989; 29:213-39. PMID: 2543270.
      Citations:    
    154. Wise WC, Cook JA, Tempel GE, Reines HD, Halushka PV. The rat in sepsis and endotoxic shock. Prog Clin Biol Res. 1989; 299:243-52. PMID: 2657793.
      Citations:    
    155. Mais DE, Halushka PV. Photoaffinity labelling of the human platelet thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor. Prog Clin Biol Res. 1989; 301:303-7. PMID: 2529550.
      Citations:    
    156. Halushka PV, Mais DE, Morinelli TA. Thromboxane and prostacyclin receptors. Prog Clin Biol Res. 1989; 301:21-8. PMID: 2529548.
      Citations:    
    157. Tempel GE, Strong JW, Wise WC, Cook JA, Smith EF, Halushka PV. The role of eicosanoids in mediating blood flow alterations in endotoxin shock. Prog Clin Biol Res. 1989; 299:33-42. PMID: 2498907.
      Citations:    
    158. Mayeux PR, Morton HE, Gillard J, Lord A, Morinelli TA, Boehm A, Mais DE, Halushka PV. The affinities of prostaglandin H2 and thromboxane A2 for their receptor are similar in washed human platelets. Biochem Biophys Res Commun. 1988 Dec 15; 157(2):733-9. PMID: 2974286.
      Citations:    
    159. Liel N, Mais DE, Halushka PV. Desensitization of platelet thromboxane A2/prostaglandin H2 receptors by the mimetic U46619. J Pharmacol Exp Ther. 1988 Dec; 247(3):1133-8. PMID: 2974487.
      Citations:    
    160. Matera G, Cook JA, Hennigar RA, Tempel GE, Wise WC, Oglesby TD, Halushka PV. Beneficial effects of a 5-lipoxygenase inhibitor in endotoxic shock in the rat. J Pharmacol Exp Ther. 1988 Oct; 247(1):363-71. PMID: 3171981.
      Citations:    
    161. Ball HA, Cook JA, Spicer KM, Hsu CY, Halushka PV. Oleic acid-induced pulmonary injury in rats: potential role of sulfidopeptide leukotrienes. Circ Shock. 1988 Sep; 26(1):59-70. PMID: 2847882.
      Citations:    
    162. Katz SA, Venkatachalam M, Crouch RK, Heffner JE, Halushka PV, Wise WC, Cook JA. Catalase pretreatment attenuates oleic acid-induced edema in isolated rabbit lung. J Appl Physiol (1985). 1988 Sep; 65(3):1301-6. PMID: 3182500.
      Citations:    
    163. Heffner JE, Katz SA, Halushka PV, Cook JA. Human platelets attenuate oxidant injury in isolated rabbit lungs. J Appl Physiol (1985). 1988 Sep; 65(3):1258-66. PMID: 3182495.
      Citations:    
    164. Mais DE, DeHoll D, Sightler H, Halushka PV. Different pharmacologic activities for 13-azapinane thromboxane A2 analogs in platelets and blood vessels. Eur J Pharmacol. 1988 Apr 13; 148(3):309-15. PMID: 2968271.
      Citations:    
    165. Saussy DL, Mais DE, Baron DA, Pepkowitz SH, Halushka PV. Subcellular localization of a thromboxane A2/prostaglandin H2 receptor antagonist binding site in human platelets. Biochem Pharmacol. 1988 Feb 15; 37(4):647-54. PMID: 2963640.
      Citations:    
    166. Hsu CY, Halushka PV, Spicer KM, Hogan EL, Martin HF. Temporal profile of thromboxane-prostacyclin imbalance in experimental spinal cord injury. J Neurol Sci. 1988 Jan; 83(1):55-62. PMID: 3346710.
      Citations:    
    167. Halushka PV, Boehm A, Mais DE. Polymyxin B increases TXA2/PGH2 agonist and antagonist affinities in human platelet membranes. Eicosanoids. 1988; 1(1):41-4. PMID: 2856171.
      Citations:    
    168. Dorn GW, Burch RM, Kochel PJ, Mais DE, Halushka PV. Decrease in agonist affinity for human platelet thromboxane A2/prostaglandin H2 receptors induced by a platelet-derived supernatant. Biochem Pharmacol. 1987 Jun 15; 36(12):1913-7. PMID: 2954555.
      Citations:    
    169. Dorn GW, Sens D, Chaikhouni A, Mais D, Halushka PV. Cultured human vascular smooth muscle cells with functional thromboxane A2 receptors: measurement of U46619-induced 45calcium efflux. Circ Res. 1987 Jun; 60(6):952-6. PMID: 2954721.
      Citations:    
    170. Liel N, Mais DE, Halushka PV. Binding of a thromboxane A2/prostaglandin H2 agonist [3H]U46619 to washed human platelets. Prostaglandins. 1987 Jun; 33(6):789-97. PMID: 2959986.
      Citations:    
    171. Halushka PV, Kochel PJ, Mais DE. Binding of thromboxane A2/prostaglandin H2 agonists to human platelets. Br J Pharmacol. 1987 May; 91(1):223-7. PMID: 3594077.
      Citations:    
    172. Smith EF, Wise WC, Halushka PV, Cook JA. Macrophage eicosanoid formation is stimulated by platelet arachidonic acid and prostaglandin endoperoxide transfer. Biochim Biophys Acta. 1987 Mar 19; 923(3):355-61. PMID: 3103691.
      Citations:    
    173. Fuhrman TM, Hollon MF, Reines HD, Olanoff LS, Halushka PV. Beneficial effects of ibuprofen in oleic acid induced lung injury. J Surg Res. 1987 Mar; 42(3):284-9. PMID: 3102855.
      Citations:    
    174. Hubbard HL, Eller TD, Mais DE, Halushka PV, Baker RH, Blair IA, Vrbanac JJ, Knapp DR. Extraction of thromboxane B2 from urine using an immobilized antibody column for subsequent analysis by gas chromatography-mass spectrometry. Prostaglandins. 1987 Feb; 33(2):149-60. PMID: 3588968.
      Citations:    
    175. Katz SA, Halushka PV, Wise WC, Cook JA. Oleic acid induces pulmonary injury independent of eicosanoids in the isolated, perfused rabbit lung. Circ Shock. 1987; 22(3):221-30. PMID: 3113757.
      Citations:    
    176. Halushka PV, Mais DE, Saussy DL. Platelet and vascular smooth muscle thromboxane A2/prostaglandin H2 receptors. Fed Proc. 1987 Jan; 46(1):149-53. PMID: 2948839.
      Citations:    
    177. Halushka PV, Lefer AM. Thromboxane A2 in health and disease. Fed Proc. 1987 Jan; 46(1):131-2. PMID: 3542572.
      Citations:    
    178. Etemadi AR, Tempel GE, Farah BA, Wise WC, Halushka PV, Cook JA. Beneficial effects of a leukotriene antagonist on endotoxin-induced acute hemodynamic alterations. Circ Shock. 1987; 22(1):55-63. PMID: 3038364.
      Citations:    
    179. Halushka PV, Mais DE, Garvin M. Binding of a thromboxane A2/prostaglandin H2 receptor antagonist to guinea-pig platelets. Eur J Pharmacol. 1986 Nov 12; 131(1):49-54. PMID: 3816947.
      Citations:    
    180. Mais DE, Burch RM, Oatis JE, Knapp DR, Halushka PV. Photoaffinity labelling of a thromboxane A2/prostaglandin H2 antagonist binding site in human platelets. Biochem Biophys Res Commun. 1986 Oct 15; 140(1):128-33. PMID: 2946292.
      Citations:    
    181. Chaikhouni A, Crawford FA, Kochel PJ, Olanoff LS, Halushka PV. Human internal mammary artery produces more prostacyclin than saphenous vein. J Thorac Cardiovasc Surg. 1986 Jul; 92(1):88-91. PMID: 3755199.
      Citations:    
    182. Hsu CY, Halushka PV, Hogan EL, Cox RD. Increased thromboxane level in experimental spinal cord injury. J Neurol Sci. 1986 Jul; 74(2-3):289-96. PMID: 3525758.
      Citations:    
    183. Tempel GE, Cook JA, Wise WC, Halushka PV, Corral D. Improvement in organ blood flow by inhibition of thromboxane synthetase during experimental endotoxic shock in the rat. J Cardiovasc Pharmacol. 1986 May-Jun; 8(3):514-9. PMID: 2425166.
      Citations:    
    184. Rogers TS, Halushka PV, Wise WC, Cook JA. Differential alteration of lipoxygenase and cyclooxygenase metabolism by rat peritoneal macrophages induced by endotoxin tolerance. Prostaglandins. 1986 Apr; 31(4):639-50. PMID: 3088676.
      Citations:    
    185. Chen ST, Hsu CY, Hogan EL, Halushka PV, Linet OI, Yatsu FM. Thromboxane, prostacyclin, and leukotrienes in cerebral ischemia. Neurology. 1986 Apr; 36(4):466-70. PMID: 3008026.
      Citations:    
    186. Saussy DL, Mais DE, Burch RM, Halushka PV. Identification of a putative thromboxane A2/prostaglandin H2 receptor in human platelet membranes. J Biol Chem. 1986 Mar 05; 261(7):3025-9. PMID: 3005276.
      Citations:    
    187. Ball HA, Cook JA, Wise WC, Halushka PV. Role of thromboxane, prostaglandins and leukotrienes in endotoxic and septic shock. Intensive Care Med. 1986; 12(3):116-26. PMID: 3016060.
      Citations:    
    188. Armstrong J, Tempel GE, Cook JA, Wise WC, Halushka PV. The effects of alpha adrenergic blockade on arachidonic acid metabolism and shock sequelae in endotoxemia. Circ Shock. 1986; 20(2):151-9. PMID: 3096591.
      Citations:    
    189. Mais DE, Burch RM, Saussy DL, Kochel PJ, Halushka PV. Binding of a thromboxane A2/prostaglandin H2 receptor antagonist to washed human platelets. J Pharmacol Exp Ther. 1985 Dec; 235(3):729-34. PMID: 3001275.
      Citations:    
    190. Saussy DL, Mais DE, Knapp DR, Halushka PV. Thromboxane A2 and prostaglandin endoperoxide receptors in platelets and vascular smooth muscle. Circulation. 1985 Dec; 72(6):1202-7. PMID: 2998641.
      Citations:    
    191. Halushka PV, Mayfield R, Colwell JA. Insulin and arachidonic acid metabolism in diabetes mellitus. Metabolism. 1985 Dec; 34(12 Suppl 1):32-6. PMID: 3934501.
      Citations:    
    192. Burch RM, Mais DE, Pepkowitz SH, Halushka PV. Hydrodynamic properties of a thromboxane A2/prostaglandin H2 antagonist binding site solubilized from human platelets. Biochem Biophys Res Commun. 1985 Nov 15; 132(3):961-8. PMID: 3000368.
      Citations:    
    193. Burch RM, Mais DE, Saussy DL, Halushka PV. Solubilization of a thromboxane A2/prostaglandin H2 antagonist binding site from human platelets. Proc Natl Acad Sci U S A. 1985 Nov; 82(21):7434-8. PMID: 2997791.
      Citations:    
    194. Mayfield RK, Halushka PV, Wohltmann HJ, Lopes-Virella M, Chambers JK, Loadholt CB, Colwell JA. Platelet function during continuous insulin infusion treatment in insulin-dependent diabetic patients. Diabetes. 1985 Nov; 34(11):1127-33. PMID: 3930325.
      Citations:    
    195. Cook JA, Wise WC, Halushka PV. Protective effect of a selective leukotriene antagonist in endotoxemia in the rat. J Pharmacol Exp Ther. 1985 Nov; 235(2):470-4. PMID: 2997435.
      Citations:    
    196. Baron DA, Burch RM, Halushka PV, Spicer SS. Blockade of colchicine-induced inhibition of vasopressin-stimulated osmotic water flow: failure to influence microtubule formation. Am J Physiol. 1985 Oct; 249(4 Pt 2):F464-9. PMID: 3931483.
      Citations:    
    197. Mais DE, Kochel PJ, Saussy DL, Halushka PV. Binding of an 125I-labeled thromboxane A2/prostaglandin H2 receptor antagonist to washed canine platelets. Mol Pharmacol. 1985 Aug; 28(2):163-9. PMID: 2991736.
      Citations:    
    198. Dorn GW, Halushka PV. Thromboxane synthetase inhibitors, thromboxane receptor antagonists, and aspirin in cardiovascular disease. Ration Drug Ther. 1985 Jul; 19(7):1-7. PMID: 2997839.
      Citations:    
    199. Hsu CY, Halushka PV, Hogan EL, Banik NL, Lee WA, Perot PL. Alteration of thromboxane and prostacyclin levels in experimental spinal cord injury. Neurology. 1985 Jul; 35(7):1003-9. PMID: 3892363.
      Citations:    
    200. Olanoff LS, Cook JA, Halushka PV. Sulindac does not preserve renal prostacyclin synthesis during endotoxemia. Prostaglandins. 1985 Jun; 29(6):1031-7. PMID: 3898231.
      Citations:    
    201. Halushka PV, Reines HD, Barrow SE, Blair IA, Dollery CT, Rambo W, Cook JA, Wise WC. Elevated plasma 6-keto-prostaglandin F1 alpha in patients in septic shock. Crit Care Med. 1985 Jun; 13(6):451-3. PMID: 3838926.
      Citations:    
    202. Mais DE, Saussy DL, Chaikhouni A, Kochel PJ, Knapp DR, Hamanaka N, Halushka PV. Pharmacologic characterization of human and canine thromboxane A2/prostaglandin H2 receptors in platelets and blood vessels: evidence for different receptors. J Pharmacol Exp Ther. 1985 May; 233(2):418-24. PMID: 2987481.
      Citations:    
    203. Mais DE, Dunlap C, Hamanaka N, Halushka PV. Further studies on the effects of epimers of thromboxane A2 antagonists on platelets and veins. Eur J Pharmacol. 1985 Apr 23; 111(1):125-8. PMID: 4018122.
      Citations:    
    204. Halushka PV, MacDermot J, Knapp DR, Eller T, Saussy DL, Mais D, Blair IA, Dollery CT. A novel approach for the study of thromboxane A2 and prostaglandin H2 receptors using an 125I-labeled ligand. Biochem Pharmacol. 1985 Apr 15; 34(8):1165-70. PMID: 2986639.
      Citations:    
    205. Reines HD, Halushka PV, Cook JA, Loadholt CB. Lack of effect of glucocorticoids upon plasma thromboxane in patients in a state of shock. Surg Gynecol Obstet. 1985 Apr; 160(4):320-2. PMID: 3983796.
      Citations:    
    206. Reines HD, Halushka PV, Olanoff LS, Hunt PS. Dazoxiben in human sepsis and adult respiratory distress syndrome. Clin Pharmacol Ther. 1985 Apr; 37(4):391-5. PMID: 3979000.
      Citations:    
    207. Margolius HS, Halushka PV, Chao J, Miller DH, Cuthbert AW, Spayne JA. Studies of the kallikrein-kinin system and prostaglandins in epithelial ion transport. Soc Gen Physiol Ser. 1985; 39:121-33. PMID: 3920759.
      Citations:    
    208. Smith EF, Tempel GE, Wise WC, Halushka PV, Cook JA. Experimental endotoxemia in the rat: efficacy of prostacyclin or the prostacyclin analog iloprost. Circ Shock. 1985; 16(1):1-7. PMID: 2414027.
      Citations:    
    209. Olanoff LS, Cook JA, Eller T, Knapp DR, Halushka PV. Protective effects of trans-13-APT, a thromboxane receptor antagonist, in endotoxemia. J Cardiovasc Pharmacol. 1985 Jan-Feb; 7(1):114-20. PMID: 2580129.
      Citations:    
    210. Wise WC, Halushka PV, Knapp RG, Cook JA. Ibuprofen, methylprednisolone, and gentamicin as conjoint therapy in septic shock. Circ Shock. 1985; 17(1):59-71. PMID: 3840416.
      Citations:    
    211. Cook JA, Wise WC, Tempel GE, Halushka PV. Exchange transfusions in rats with a perfluorated blood substitute: effect on thromboxane B2 levels during endotoxemia. Circ Shock. 1985; 15(3):193-204. PMID: 3978769.
      Citations:    
    212. Burch RM, Halushka PV. ADH or theophylline-induced changes in intracellular free and membrane-bound calcium. Am J Physiol. 1984 Dec; 247(6 Pt 2):F939-45. PMID: 6439053.
      Citations:    
    213. Cuthbert AW, Halushka PV, Kessel D, Margolius HS, Wise WC. Kinin effects on chloride secretion do not require eicosanoid synthesis. Br J Pharmacol. 1984 Oct; 83(2):549-54. PMID: 6593108.
      Citations:    
    214. Cuthbert AW, Halushka PV, Margolius HS, Spayne JA. Mediators of the secretory response to kinins. Br J Pharmacol. 1984 Jul; 82(3):597-607. PMID: 6331559.
      Citations:    
    215. Cuthbert AW, Halushka PV, Margolius HS, Spayne JA. Role of calcium ions in kinin-induced chloride secretion. Br J Pharmacol. 1984 Jul; 82(3):587-95. PMID: 6331558.
      Citations:    
    216. Olanoff LS, Reines HD, Spicer KM, Halushka PV. Effects of oleic acid on pulmonary capillary leak and thromboxanes. J Surg Res. 1984 Jun; 36(6):597-605. PMID: 6233456.
      Citations:    
    217. Burch RM, Halushka PV. Alterations in extracellular calcium concentration differentially influence prostaglandin and thromboxane synthesis in epithelial cells from the toad urinary bladder. Arch Biochem Biophys. 1984 Feb 15; 229(1):90-7. PMID: 6422855.
      Citations:    
    218. Rogers TS, Smith EF, Wise WC, Halushka PV, Cook JA. Interaction of eicosanoids and macrophages during inflammatory responses. Surv Immunol Res. 1984; 3(2-3):161-4. PMID: 6718845.
      Citations:    
    219. Cook JA, Wise WC, Butler RR, Reines HD, Rambo W, Halushka PV. The potential role of thromboxane and prostacyclin in endotoxic and septic shock. Am J Emerg Med. 1984 Jan; 2(1):28-37. PMID: 6440569.
      Citations:    
    220. Colwell JA, Winocour PD, Lopes-Virella M, Halushka PV. New concepts about the pathogenesis of atherosclerosis in diabetes mellitus. Am J Med. 1983 Nov 30; 75(5B):67-80. PMID: 6424441.
      Citations:    
    221. Burch RM, Wise WC, Halushka PV. Prostaglandin-independent inhibition of calcium transport by nonsteroidal anti-inflammatory drugs: differential effects of carboxylic acids and piroxicam. J Pharmacol Exp Ther. 1983 Oct; 227(1):84-91. PMID: 6312024.
      Citations:    
    222. Chong KP, Burch RM, Black M, Maloney E, Jollow DJ, Halushka PV. Vasopressin stimulates thromboxane synthesis in isolated hamster hepatocytes: relation to hepatocyte calcium content. Prostaglandins. 1983 Sep; 26(3):397-408. PMID: 6419286.
      Citations:    
    223. Burch RM, Halushka PV. Verapamil inhibition of vasopressin-stimulated water flow: possible role of intracellular calcium. J Pharmacol Exp Ther. 1983 Sep; 226(3):701-5. PMID: 6411896.
      Citations:    
    224. Halushka PV, Wise WC, Cook JA. Studies on the beneficial effects of aspirin in endotoxic shock. Relationship to inhibition of arachidonic acid metabolism. Am J Med. 1983 Jun 14; 74(6A):91-6. PMID: 6687979.
      Citations:    
    225. Colwell JA, Winocour PD, Halushka PV. Do platelets have anything to do with diabetic microvascular disease? Diabetes. 1983 May; 32 Suppl 2:14-9. PMID: 6242836.
      Citations:    
    226. Butler RR, Wise WC, Halushka PV, Cook JA. Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production. J Pharmacol Exp Ther. 1983 Apr; 225(1):94-101. PMID: 6339712.
      Citations:    
    227. Anderegg K, Anzeveno P, Cook JA, Halushka PV, McCarthy J, Wagner E, Wise WC. Effects of a pyridine derivative thromboxane synthetase inhibitor and its inactive isomer in endotoxic shock in the rat. Br J Pharmacol. 1983 Apr; 78(4):725-32. PMID: 6687819.
      Citations:    
    228. Newman WH, Frankis MB, Halushka PV. Increased myocardial release of prostacyclin in dogs with heart failure. J Cardiovasc Pharmacol. 1983 Mar-Apr; 5(2):194-201. PMID: 6188889.
      Citations:    
    229. Burch RM, Halushka PV. 45Ca fluxes in isolated toad bladder epithelial cells: effects of agents which alter water or sodium transport. J Pharmacol Exp Ther. 1983 Jan; 224(1):108-17. PMID: 6294273.
      Citations:    
    230. Wise WC, Cook JA, Halushka PV. Arachidonic acid metabolism in endotoxin tolerance. Adv Shock Res. 1983; 10:131-42. PMID: 6410699.
      Citations:    
    231. Halushka PV, Cook JA, Wise WC. Beneficial effects of UK 37248, a thromboxane synthetase inhibitor, in experimental endotoxic shock in the rat. Br J Clin Pharmacol. 1983; 15 Suppl 1:133S-139S. PMID: 6337604.
      Citations:    
    232. Halushka PV, Dollery CT, MacDermot J. Thromboxane and prostacyclin in disease: a review. Q J Med. 1983; 52(208):461-70. PMID: 6361838.
      Citations:    
    233. Hohn AR, Riopel DA, Keil JE, Loadholt CB, Margolius HS, Halushka PV, Privitera PJ, Webb JG, Medley ES, Schuman SH, Rubin MI, Pantell RH, Braunstein ML. Childhood familial and racial differences in physiologic and biochemical factors related to hypertension. Hypertension. 1983 Jan-Feb; 5(1):56-70. PMID: 6336720.
      Citations:    
    234. Burch RM, Halushka PV. Vasopressin stimulates prostaglandin and thromboxane synthesis in toad bladder epithelial cells. Am J Physiol. 1982 Dec; 243(6):F593-7. PMID: 6816073.
      Citations:    
    235. Kelley VE, Izui S, Halushka PV. Effect of ibuprofen, a fatty acid cyclooxygenase inhibitor, on murine lupus. Clin Immunol Immunopathol. 1982 Nov; 25(2):223-31. PMID: 6819912.
      Citations:    
    236. Wilson TW, Loadholt CB, Privitera PJ, Halushka PV. Furosemide increases urine 6-keto-prostaglandin F1 alpha. Relation to natriuresis, vasodilation, and renin release. Hypertension. 1982 Sep-Oct; 4(5):634-41. PMID: 7049918.
      Citations:    
    237. Reines HD, Halushka PV, Cook JA, Wise WC, Rambo W. Plasma thromboxane concentrations are raised in patients dying with septic shock. Lancet. 1982 Jul 24; 2(8291):174-5. PMID: 6123885.
      Citations:    
    238. Colwell JA, Halushka PV. Platelets, prostaglandins, and coagulation in diabetes mellitus. Mt Sinai J Med. 1982 May-Jun; 49(3):215-22. PMID: 6811864.
      Citations:    
    239. Butler RR, Wise WC, Halushka PV, Cook JA. Thromboxane and prostacyclin production during septic shock. Adv Shock Res. 1982; 7:133-45. PMID: 6753528.
      Citations:    
    240. Tempel GE, Cook JA, Wise WC, Halushka PV. The improvement in endotoxin-induced redistribution of organ blood flow by inhibition of thromboxane and prostaglandin synthesis. Adv Shock Res. 1982; 7:209-18. PMID: 6753535.
      Citations:    
    241. Cook JA, Halushka PV, Wise WC. Modulation of macrophage arachidonic acid metabolism: potential role in the susceptibility of rats to endotoxic shock. Circ Shock. 1982; 9(6):605-17. PMID: 7151266.
      Citations:    
    242. Burch RM, Halushka PV. Inhibition of prostaglandin synthesis antagonizes the colchicine-induced reduction of vasopressin-stimulated water flow in the toad urinary bladder. Mol Pharmacol. 1982 Jan; 21(1):142-9. PMID: 6290865.
      Citations:    
    243. Russel MP, Privitera PJ, Walle T, Peet NP, Halushka PV, Gaffney TE. Cardiovascular effects of a 4'-methylthio analog of propranolol. J Pharmacol Exp Ther. 1981 Dec; 219(3):685-90. PMID: 6117655.
      Citations:    
    244. Grimm LJ, Knapp DR, Senator D, Halushka PV. Inhibition of platelet thromboxane synthesis by 7-(1-imidazolyl) heptanoic acid: dissociation from inhibition of aggregation. Thromb Res. 1981 Nov 15; 24(4):307-17. PMID: 6801806.
      Citations:    
    245. Cook JA, Wise WC, Halushka PV. Thromboxane A2 and prostacyclin production by lipopolysaccharide-stimulated peritoneal macrophages. J Reticuloendothel Soc. 1981 Nov; 30(5):445-50. PMID: 7033530.
      Citations:    
    246. Halushka PV, Wise WC, Cook JA. Protective effects of aspirin in endotoxic shock. J Pharmacol Exp Ther. 1981 Aug; 218(2):464-9. PMID: 6894770.
      Citations:    
    247. Halushka PV, Mayfield R, Wohltmann HJ, Rogers RC, Goldberg AK, McCoy SA, Loadholt CB, Colwell JA. Increased platelet arachidonic acid metabolism in diabetes mellitus. Diabetes. 1981; 30(Suppl 2):44-8. PMID: 6795072.
      Citations:    
    248. Cook JA, Wise WC, Knapp DR, Halushka PV. Sensitization of essential fatty acid-deficient rats to endotoxin by arachidonate pretreatment: role of thromboxane A2. Circ Shock. 1981; 8(1):69-76. PMID: 7237685.
      Citations:    
    249. Halushka PV, Rogers RC, Loadholt CB, Wohltman H, Mayfield R, McCoy S, Colwell JA. Increased platelet prostaglandin and thromboxane synthesis in diabetes mellitus. Horm Metab Res Suppl. 1981; 11:7-11. PMID: 7033097.
      Citations:    
    250. Halushka PV, Rogers RC, Loadholt CB, Colwell JA. Increased platelet thromboxane synthesis in diabetes mellitus. J Lab Clin Med. 1981 Jan; 97(1):87-96. PMID: 7452084.
      Citations:    
    251. Wise WC, Cook JA, Halushka PV. Implications for thromboxane A2 in the pathogenesis of endotoxic shock. Adv Shock Res. 1981; 6:83-91. PMID: 6961767.
      Citations:    
    252. Cook JA, Wise WC, Knapp DR, Halushka PV. Essential fatty acid deficient rats: a new model for evaluating arachidonate metabolism in shock. Adv Shock Res. 1981; 6:93-105. PMID: 6818852.
      Citations:    
    253. Colwell JA, Lopes-Virella M, Halushka PV. Pathogenesis of atherosclerosis in diabetes mellitus. Diabetes Care. 1981 Jan-Feb; 4(1):121-33. PMID: 7009108.
      Citations:    
    254. Burch RM, Halushka PV. Thromboxane and stable prostaglandin endoperoxide analogs stimulate water permeability in the toad urinary bladder. J Clin Invest. 1980 Dec; 66(6):1251-7. PMID: 6777398.
      Citations:    
    255. Wise WC, Cook JA, Eller T, Halushka PV. Ibuprofen improves survival from endotoxic shock in the rat. J Pharmacol Exp Ther. 1980 Oct; 215(1):160-4. PMID: 7452480.
      Citations:    
    256. Burch RM, Knapp DR, Halushka PV. Vasopressin-stimulated water flow is decreased by thromboxane synthesis inhibition or antagonism. Am J Physiol. 1980 Aug; 239(2):F160-6. PMID: 6773424.
      Citations:    
    257. Halushka PV, Levanho A, Auber M. Arachidonic acid stimulates short-circuit current in the isolated toad urinary bladder. J Pharmacol Exp Ther. 1980 Jun; 213(3):462-7. PMID: 6782235.
      Citations:    
    258. Wise WC, Cook JA, Halushka PV, Knapp DR. Protective effects of thromboxane synthetase inhibitors in rats in endotoxic shock. Circ Res. 1980 Jun; 46(6):854-9. PMID: 7189697.
      Citations:    
    259. Colwell JA, Halushka PV. Platelet function in diabetes mellitus. Br J Haematol. 1980 Apr; 44(4):521-6. PMID: 6769461.
      Citations:    
    260. Korn JH, Halushka PV, LeRoy EC. Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production. J Clin Invest. 1980 Feb; 65(2):543-54. PMID: 7356693.
      Citations:    
    261. Cook JA, Wise WC, Halushka PV. Elevated thromboxane levels in the rat during endotoxic shock: protective effects of imidazole, 13-azaprostanoic acid, or essential fatty acid deficiency. J Clin Invest. 1980 Jan; 65(1):227-30. PMID: 7350199.
      Citations:    
    262. Burch RM, Knapp DR, Halushka PV. Vasopressin stimulates thromboxane synthesis in the toad urinary bladder: effects of thromboxane synthesis inhibition. Adv Prostaglandin Thromboxane Res. 1980; 6:505-9. PMID: 6770606.
      Citations:    
    263. Halushka PV, Levanho A, Auber M. Prostacyclin stimulates short circuit current in the isolated toad (Bufo marinus) urinary bladder. Adv Prostaglandin Thromboxane Res. 1980; 8:1269-72. PMID: 6769307.
      Citations:    
    264. Halushka PV, Margolius HS, Allen H, Conradi EC. Urinary excretion of prostaglandin E like material and kallikrein: effects of furosemide. Prostaglandins. 1979 Sep; 18(3):359-68. PMID: 260996.
      Citations:    
    265. Burch RM, Knapp DR, Halushka PV. Vasopressin stimulates thromboxane synthesis in the toad urinary bladder: effects of imidazole. J Pharmacol Exp Ther. 1979 Sep; 210(3):344-8. PMID: 113526.
      Citations:    
    266. Le Breton GC, Venton DL, Enke SE, Halushka PV. 13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor. Proc Natl Acad Sci U S A. 1979 Aug; 76(8):4097-101. PMID: 291066.
      Citations:    
    267. Colwell JA, Nair RM, Halushka PV, Rogers C, Whetsell A, Sagel J. Platelet adhesion and aggregation in diabetes mellitus. Metabolism. 1979 Apr; 28(4 Suppl 1):394-400. PMID: 122293.
      Citations:    
    268. Hsu CY, Knapp DR, Halushka PV. The effects of alpha adrenergic agents on human platelet aggregation. J Pharmacol Exp Ther. 1979 Mar; 208(3):366-70. PMID: 34707.
      Citations:    
    269. Colwell JA, Halushka PV, Sarji KE, Lopes-Virella MF, Sagel J. Vascular disease in diabetes: pathophysiological mechanisms and therapy. Arch Intern Med. 1979 Feb; 139(2):225-30. PMID: 434977.
      Citations:    
    270. Halushka PV, Knapp DR, Grimm L. Prostaglandins, thromboxanes, and platelet function. Curr Top Hematol. 1979; 2:75-143. PMID: 233629.
      Citations:    
    271. Colwell JA, Halushka PV, Sarji KE, Sagel J. Platelet function and diabetes mellitus. Med Clin North Am. 1978 Jul; 62(4):753-66. PMID: 355740.
      Citations:    
    272. Webb JG, Saelens DA, Halushka PV. Biosynthesis of prostaglandin E by rat superior cervical ganglia. J Neurochem. 1978 Jul; 31(1):13-9. PMID: 209139.
      Citations:    
    273. Colwell JA, Halushka PV, Sarji KE, Sagal J. Rationale for antiplatelet agents in diabetic vascular disease. Adv Exp Med Biol. 1978; 102:243-54. PMID: 356561.
      Citations:    
    274. Maxwell WA, Halushka PV, Miller RL, Spicer SS, Westphal MC, Penny LD. Elevated prostaglandin production in cultured cells from a patient with fibrodysplasia ossificans progressiva. Prostaglandins. 1978 Jan; 15(1):123-9. PMID: 415337.
      Citations:    
    275. Halushka PV, Lurie D, Colwell JA. Increased synthesis of prostaglandin-E-like material by platelets from patients with diabetes mellitus. N Engl J Med. 1977 Dec 15; 297(24):1306-10. PMID: 917087.
      Citations:    
    276. Sawyer PR, Cowart TD, Hurwitz GA, Halushka PV, Jollow DJ. Acetaminophen overdosage. J S C Med Assoc. 1977 Nov; 73(11):474-80. PMID: 270599.
      Citations:    
    277. Miller RL, Maxwell WA, Spicer SS, Halushka PV, Varner HH, Westphal MC. Studies on alkaline phosphatase activity cultured cells from a patient with fibrodysplasia ossificans progressiva. Lab Invest. 1977 Sep; 37(3):254-9. PMID: 408558.
      Citations:    
    278. Halushka PV, Wohltmann H, Privitera PJ, Hurwitz G, Margolius HS. Bartter's syndrome: urinary prostaglandin E-like material and kallikrein; indomethacin effects. Ann Intern Med. 1977 Sep; 87(3):281-6. PMID: 900671.
      Citations:    
    279. Maxwell WA, Spicer SS, Miller RL, Halushka PV, Westphal MC, Setser ME. Histochemical and ultrastructural studies in fibrodysplasia ossificans progressiva (myositis ossificans progressiva). Am J Pathol. 1977 Jun; 87(3):483-98. PMID: 141214.
      Citations:    
    280. Colwell JA, Halushka PV, Sarji K, Levine J, Sagel J, Nair RM. Altered platelet function in diabetes mellitus. Diabetes. 1976; 25(2 SUPPL):826-31. PMID: 823064.
      Citations:    
    281. Halushka PV, Keiser HR. Acute effects of alpha-methyldopa on mean blood pressure and plasma renin activity. Circ Res. 1974 Sep; 35(3):458-63. PMID: 4370852.
      Citations:    
    282. Brereton HD, Halushka PV, Alexander RW, Mason DM, Keiser HR, DeVita VT. Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma. N Engl J Med. 1974 Jun 11; 291(2):83-5. PMID: 4835887.
      Citations:    
    283. Whitsett TL, Halushka PV, Goldberg LI. Attenuation of postganglionic sympathetic nerve activity by L-dopa. Circ Res. 1970 Oct; 27(4):561-70. PMID: 5507033.
      Citations:    
    284. Halushka PV, Hoffmann PC. Alcohol addiction and tetrahydropapaveroline. Science. 1970 Sep 11; 169(3950):1104-5. PMID: 5465178.
      Citations:    
    285. Halushka PV, Hoffmann PC. Distribution and metabolism of dopamine in guinea-pigs. J Pharm Pharmacol. 1968 Dec; 20(12):943-6. PMID: 4388335.
      Citations:    
    286. Halushka PV, Hoffmann PC. Does tetrahydroparaveroline contribute to the cardiovascular actions of dopamine? Biochem Pharmacol. 1968 Sep; 17(9):1873-80. PMID: 5688274.
      Citations:    
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