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Patrick M Woster

Title
InstitutionMedical University of South Carolina
DepartmentCOP Drug Discovery and Biomedical Sciences - MUSC Campus
AddressP.O. Box MSC139
DD405
Drug Discovery Building - 70 President St.
Phone843-876-2453
Fax843-876-2353
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    Collapse Biography 
    Collapse awards and honors
    1993President's Award for Excellence in Teaching, Wayne State University
    1998Eugene Applebaum College of Pharmacy and Health Sciences Teaching Excellence Award, Wayne State University
    1998 - 1999Career Development Chair, Wayne State University
    2006Eugene Applebaum College of Pharmacy and Health Sciences Teaching Excellence Award, Wayne State University
    2009Chair, Gordon Research Conference and Graduate Research Seminar on Polyamines, Gordon Research Conferences
    2010College of Pharmacy and Allied Health Research Excellence Award, Wayne State University
    2011 - presSmartState Endowed Chair in Drug Discovery, Medical University of South Carolina
    2011 - presDirector, MUSC Lead Discovery and Optimization Core, South Carolina Center for Therapeutic Discovery and Development
    2013Organizer, 2013 Frontiers in Medicinal Chemistry Symposium, Division of Medicinal Chemistry, American Chemical Society
    2014Chair and Organizer, 34th National Medicinal Chemistry Symposium, Division of Medicinal Chemistry, American Chemical Society
    2014 - presFellow of the American Chemical Society, American Chemical Society
    1994 - 2011Secretary and Public Relations Chair, Division of Medicinal Chemistry, American Chemical Society
    2011 - 2013Chair, Division of Medicinal Chemistry, American Chemical Society
    2014 - presMembership and International Relations Chair, Division of Medicinal Chemistry, American Chemical Society
    2014Fellow, American Chemical Society
    2014Fellow, American Foundation for Pharmacy Education
    2016Fellow, Royal Society of Chemistry

    Collapse Overview 
    Collapse overview
    Dr. Patrick M. Woster received a B.S. degree in Pharmacy in 1978 and a Ph.D. in medicinal chemistry in 1986, both from the University of Nebraska. He completed postdoctoral work in the laboratory of James Coward at Rensselaer Polytechnic Institute (chemistry) and the University of Michigan (medicinal chemistry), and then joined the faculty at Wayne State University as an assistant professor in 1988. He was promoted to Professor of Pharmaceutical Sciences in 2000. Dr. Woster moved to the Medical University of South Carolina in 2011, where he is Professor, Interim Chair of Drug Discovery and Biomedical Sciences and the South Carolina SmartState™ Endowed Chair in Drug Discovery (2011-present). He also serves as Director of the MUSC Drug Design and Synthesis Core. Professor Woster maintains an active research program that has been funded by NIH, WHO and the pharmaceutical industry. Ongoing projects in the Woster laboratories include the synthesis of novel inhibitors of lysine-specific demethylase 1 and histone deacetylases as epigenetic modulators, synthesis of oligoamines as antitumor, antibacterial or antimalarial agents, design and synthesis of small molecules and cyclic/stapled peptide analogues as epigenetic modulators and the synthesis of mechanism-based enzyme inactivators. Dr. Woster has directed 12 Ph.D. dissertations and 4 Master's theses, and has mentored 11 postdoctoral associates. To date, he has authored more than 120 articles in peer-reviewed research journals, 120 research abstracts and 15 patent applications. He is a frequent invited speaker, both nationally and internationally, and has organized a number of scientific conferences, including the 2009 Gordon Research Conference and Graduate Research Seminar on Polyamines, and the 34th National Medicinal Chemistry Symposium. Dr. Woster has served as a member of many NIH study sections and other grant review panels, and serves on editorial boards or as a reviewer for numerous scientific journals. He has also been an active member of American Chemical Society (ACS), and has served as an officer in the Division of Medicinal Chemistry for 21 years.

    Collapse keywords
    drug discovery, medicinal chemistry, epigenetic, histone demethylase, histone deacetylase, antimalarial, antibacterial, antiparasitic, polyamine

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wimborne HJ, Takemoto K, Woster PM, Rockey DC, Lemasters JJ, Zhong Z. Aldehyde dehydrogenase-2 activation by Alda-1 decreases necrosis and fibrosis after bile duct ligation in mice. Free Radic Biol Med. 2019 Dec; 145:136-145. PMID: 31557514.
      View in: PubMed
    2. Woster PM. Citizenship in the World of Medicinal Chemistry: 25 Years as an ACSMEDI Volunteer. ACS Med Chem Lett. 2019 May 09; 10(5):696-698. PMID: 31097983.
      View in: PubMed
    3. El Bissati K, Redel H, Ting LM, Lykins JD, McPhillie MJ, Upadhya R, Woster PM, Yarlett N, Kim K, Weiss LM. Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations. Front Cell Infect Microbiol. 2019; 9:9. PMID: 30838177.
      View in: PubMed
    4. Holshouser S, Dunworth M, Murray-Stewart T, Peterson YK, Burger P, Kirkpatrick J, Chen HH, Casero RA, Woster PM. Dual inhibitors of LSD1 and spermine oxidase. Medchemcomm. 2019 May 01; 10(5):778-790. PMID: 31191868.
      View in: PubMed
    5. Murray Stewart T, Dunston TT, Woster PM, Casero RA. Polyamine catabolism and oxidative damage. J Biol Chem. 2018 11 30; 293(48):18736-18745. PMID: 30333229.
      View in: PubMed
    6. Murray-Stewart T, Dunworth M, Lui Y, Giardiello FM, Woster PM, Casero RA. Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies. PLoS One. 2018; 13(8):e0202677. PMID: 30138353.
      View in: PubMed
    7. Kirkpatrick JE, Kirkwood KL, Woster PM. Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis. Epigenetics. 2018; 13(5):557-572. PMID: 29927684.
      View in: PubMed
    8. Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA, Woster PM. Corrigendum to "Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures" [Bioorg. Med. Chem. 23 (2015) 1601-1612]. Bioorg Med Chem. 2018 07 23; 26(12):3728-3729. PMID: 29859749.
      View in: PubMed
    9. Kumarasinghe IR, Woster PM. Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis. Eur J Med Chem. 2018 Mar 25; 148:210-220. PMID: 29459279.
      View in: PubMed
    10. Murray-Stewart TR, Woster PM, Casero RA. Targeting polyamine metabolism for cancer therapy and prevention. Biochem J. 2016 10 01; 473(19):2937-53. PMID: 27679855.
      View in: PubMed
    11. Wang B, Pachaiyappan B, Gruber JD, Schmidt MG, Zhang YM, Woster PM. Antibacterial Diamines Targeting Bacterial Membranes. J Med Chem. 2016 Apr 14; 59(7):3140-51. PMID: 26964758.
      View in: PubMed
    12. Conway SJ, Woster PM, Greenlee WJ, Georg G, Wang S. Epigenetics: Novel Therapeutics Targeting Epigenetics. J Med Chem. 2016 Feb 25; 59(4):1247-8. PMID: 26824165.
      View in: PubMed
    13. Li Y, Woster PM. Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group. Medchemcomm. 2015 Apr 01; 6(4):613-618. PMID: 26005563.
      View in: PubMed
    14. Maganti AV, Maier B, Tersey SA, Sampley ML, Mosley AL, Özcan S, Pachaiyappan B, Woster PM, Hunter CS, Stein R, Mirmira RG. Transcriptional activity of the islet ß cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9. J Biol Chem. 2015 Apr 10; 290(15):9812-22. PMID: 25713082.
      View in: PubMed
    15. Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA, Woster PM. Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures. Bioorg Med Chem. 2015 Apr 01; 23(7):1601-12. PMID: 25725609.
      View in: PubMed
    16. Verlinden BK, de Beer M, Pachaiyappan B, Besaans E, Andayi WA, Reader J, Niemand J, van Biljon R, Guy K, Egan T, Woster PM, Birkholtz LM. Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites. Bioorg Med Chem. 2015 Aug 15; 23(16):5131-43. PMID: 25684422.
      View in: PubMed
    17. Conway SJ, Woster PM, Shen JK, Georg G, Wang S. Epigenetics: novel therapeutics targeting epigenetics. J Med Chem. 2015 Jan 22; 58(2):523-4. PMID: 25532017.
      View in: PubMed
    18. Kutz CJ, Holshouser SL, Marrow EA, Woster PM. 3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors. Medchemcomm. 2014 Dec; 5(12):1863-1870. PMID: 25580204.
      View in: PubMed
    19. Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM, Fox JG, Woster PM, Casero RA, Correa P, Wilson KT. Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene. 2015 Jun; 34(26):3429-40. PMID: 25174398.
      View in: PubMed
    20. Pachaiyappan B, Woster PM. Design of small molecule epigenetic modulators. Bioorg Med Chem Lett. 2014 Jan 01; 24(1):21-32. PMID: 24300735.
      View in: PubMed
    21. Kumarasinghe IR, Woster PM. Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1. ACS Med Chem Lett. 2014 Jan 09; 5(1):29-33. PMID: 24883177.
      View in: PubMed
    22. Yedidi RS, Liu Z, Kovari IA, Woster PM, Kovari LC. P1 and P1' para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease. J Mol Graph Model. 2014 Feb; 47:18-24. PMID: 24291501.
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    23. Dewdney TG, Wang Y, Liu Z, Sharma SK, Reiter SJ, Brunzelle JS, Kovari IA, Woster PM, Kovari LC. Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease. Bioorg Med Chem. 2013 Dec 01; 21(23):7430-4. PMID: 24128815.
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    24. Murray-Stewart T, Hanigan CL, Woster PM, Marton LJ, Casero RA. Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism. Mol Cancer Ther. 2013 Oct; 12(10):2088-99. PMID: 23943804.
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    25. Hayes CS, DeFeo-Mattox K, Woster PM, Gilmour SK. Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites. Amino Acids. 2014 Mar; 46(3):543-52. PMID: 23884694.
      View in: PubMed
    26. Murray-Stewart T, Woster PM, Casero RA. The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines. Amino Acids. 2014 Mar; 46(3):585-94. PMID: 23508577.
      View in: PubMed
    27. Nowotarski SL, Woster PM, Casero RA. Polyamines and cancer: implications for chemotherapy and chemoprevention. Expert Rev Mol Med. 2013 Feb 22; 15:e3. PMID: 23432971.
      View in: PubMed
    28. Jin L, Hanigan CL, Wu Y, Wang W, Park BH, Woster PM, Casero RA. Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner. Biochem J. 2013 Jan 15; 449(2):459-68. PMID: 23072722.
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    29. Hazeldine S, Pachaiyappan B, Steinbergs N, Nowotarski S, Hanson AS, Casero RA, Woster PM. Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1. J Med Chem. 2012 Sep 13; 55(17):7378-91. PMID: 22876979.
      View in: PubMed
    30. Yedidi RS, Liu Z, Wang Y, Brunzelle JS, Kovari IA, Woster PM, Kovari LC, Gupta D. Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds. Biochem Biophys Res Commun. 2012 May 11; 421(3):413-7. PMID: 22469467.
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    31. Schenk T, Chen WC, Göllner S, Howell L, Jin L, Hebestreit K, Klein HU, Popescu AC, Burnett A, Mills K, Casero RA, Marton L, Woster P, Minden MD, Dugas M, Wang JC, Dick JE, Müller-Tidow C, Petrie K, Zelent A. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med. 2012 Mar 11; 18(4):605-11. PMID: 22406747.
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    32. Silva TM, Oredsson S, Persson L, Woster P, Marques MP. Novel Pt(II) and Pd(II) complexes with polyamine analogues: synthesis and vibrational analysis. J Inorg Biochem. 2012 Mar; 108:1-7. PMID: 22265832.
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    33. Sharma SK, Hazeldine S, Crowley ML, Hanson A, Beattie R, Varghese S, Senanayake TM, Hirata A, Hirata F, Huang Y, Wu Y, Steinbergs N, Murray-Stewart T, Bytheway I, Casero RA, Woster PM. Polyamine-based small molecule epigenetic modulators. Medchemcomm. 2012; 3(1):14-21. PMID: 23293738.
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    34. Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ. Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. J Biol Chem. 2011 Dec 16; 286(50):43301-12. PMID: 22025614.
      View in: PubMed
    35. Verlinden BK, Niemand J, Snyman J, Sharma SK, Beattie RJ, Woster PM, Birkholtz LM. Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities. J Med Chem. 2011 Oct 13; 54(19):6624-33. PMID: 21882831.
      View in: PubMed
    36. Goodwin AC, Destefano Shields CE, Wu S, Huso DL, Wu X, Murray-Stewart TR, Hacker-Prietz A, Rabizadeh S, Woster PM, Sears CL, Casero RA. Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15354-9. PMID: 21876161.
      View in: PubMed
    37. Fraser AV, Goodwin AC, Hacker-Prietz A, Sugar E, Woster PM, Casero RA. Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells. Amino Acids. 2012 Feb; 42(2-3):529-38. PMID: 21814790.
      View in: PubMed
    38. Zhu Q, Huang Y, Marton LJ, Woster PM, Davidson NE, Casero RA. Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells. Amino Acids. 2012 Feb; 42(2-3):887-98. PMID: 21805138.
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    39. Woster PM. Use of polyamine derivatives as selective histone deacetylase inhibitors. Methods Mol Biol. 2011; 720:475-91. PMID: 21318894.
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    40. Cervelli M, Bellavia G, Fratini E, Amendola R, Polticelli F, Barba M, Federico R, Signore F, Gucciardo G, Grillo R, Woster PM, Casero RA, Mariottini P. Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm. BMC Cancer. 2010 Oct 14; 10:555. PMID: 20946629.
      View in: PubMed
    41. Sharma SK, Wu Y, Steinbergs N, Crowley ML, Hanson AS, Casero RA, Woster PM. (Bis)urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators. J Med Chem. 2010 Jul 22; 53(14):5197-212. PMID: 20568780.
      View in: PubMed
    42. Gupta D, Yedidi RS, Varghese S, Kovari LC, Woster PM. Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents. J Med Chem. 2010 May 27; 53(10):4234-47. PMID: 20438064.
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    43. Lee SB, Park JH, Woster PM, Casero RA, Park MH. Suppression of exogenous gene expression by spermidine/spermine N1-acetyltransferase 1 (SSAT1) cotransfection. J Biol Chem. 2010 May 14; 285(20):15548-56. PMID: 20212040.
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    44. Woster PM. Foreword: American Chemical Society Division of Medicinal Chemistry. Celebrating 100 years of excellence. J Med Chem. 2009 Dec 10; 52(23):7333-8. PMID: 19954244.
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    45. Huang Y, Stewart TM, Wu Y, Baylin SB, Marton LJ, Perkins B, Jones RJ, Woster PM, Casero RA. Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes. Clin Cancer Res. 2009 Dec 01; 15(23):7217-28. PMID: 19934284.
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    46. Huang Y, Marton LJ, Woster PM, Casero RA. Polyamine analogues targeting epigenetic gene regulation. Essays Biochem. 2009 Nov 04; 46:95-110. PMID: 20095972.
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    47. Senanayake MD, Amunugama H, Boncher TD, Casero RA, Woster PM. Design of polyamine-based therapeutic agents: new targets and new directions. Essays Biochem. 2009 Nov 04; 46:77-94. PMID: 20095971.
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    48. Basu HS, Thompson TA, Church DR, Clower CC, Mehraein-Ghomi F, Amlong CA, Martin CT, Woster PM, Lindstrom MJ, Wilding G. A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 2009 Oct 01; 69(19):7689-95. PMID: 19773450.
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    49. Pledgie-Tracy A, Billam M, Hacker A, Sobolewski MD, Woster PM, Zhang Z, Casero RA, Davidson NE. The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines. Cancer Chemother Pharmacol. 2010 May; 65(6):1067-81. PMID: 19727732.
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    50. Casero RA, Woster PM. Recent advances in the development of polyamine analogues as antitumor agents. J Med Chem. 2009 Aug 13; 52(15):4551-73. PMID: 19534534.
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    51. Susick L, Senanayake T, Veluthakal R, Woster PM, Kowluru A. A novel histone deacetylase inhibitor prevents IL-1beta induced metabolic dysfunction in pancreatic beta-cells. J Cell Mol Med. 2009 Aug; 13(8B):1877-85. PMID: 20141611.
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    52. Uimari A, Keinänen TA, Karppinen A, Woster P, Uimari P, Jänne J, Alhonen L. Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts. Biochem J. 2009 Jul 29; 422(1):101-9. PMID: 19473115.
      View in: PubMed
    53. Bacchi CJ, Yarlett N, Faciane E, Bi X, Rattendi D, Weiss LM, Woster PM. Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi. Antimicrob Agents Chemother. 2009 Jun; 53(6):2599-604. PMID: 19223636.
      View in: PubMed
    54. Wei G, DeFeo K, Hayes CS, Woster PM, Mandik-Nayak L, Gilmour SK. Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes. Cancer Res. 2008 Apr 01; 68(7):2214-22. PMID: 18381427.
      View in: PubMed
    55. Varghese S, Senanayake T, Murray-Stewart T, Doering K, Fraser A, Casero RA, Woster PM. Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors. J Med Chem. 2008 Apr 24; 51(8):2447-56. PMID: 18348516.
      View in: PubMed
    56. Wang X, Feith DJ, Welsh P, Coleman CS, Lopez C, Woster PM, O'Brien TG, Pegg AE. Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis. Carcinogenesis. 2007 Nov; 28(11):2404-11. PMID: 17675337.
      View in: PubMed
    57. Huang Y, Greene E, Murray Stewart T, Goodwin AC, Baylin SB, Woster PM, Casero RA. Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):8023-8. PMID: 17463086.
      View in: PubMed
    58. Boncher T, Bi X, Varghese S, Casero RA, Woster PM. Polyamine-based analogues as biochemical probes and potential therapeutics. Biochem Soc Trans. 2007 Apr; 35(Pt 2):356-63. PMID: 17371278.
      View in: PubMed
    59. Rider JE, Hacker A, Mackintosh CA, Pegg AE, Woster PM, Casero RA. Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide. Amino Acids. 2007 Aug; 33(2):231-40. PMID: 17396215.
      View in: PubMed
    60. Bi X, Lopez C, Bacchi CJ, Rattendi D, Woster PM. Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity. Bioorg Med Chem Lett. 2006 Jun 15; 16(12):3229-32. PMID: 16616495.
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    61. Khan FD, Roychowdhury S, Nemes R, Vyas PM, Woster PM, Svensson CK. Effect of pro-inflammatory cytokines on the toxicity of the arylhydroxylamine metabolites of sulphamethoxazole and dapsone in normal human keratinocytes. Toxicology. 2006 Feb 01; 218(2-3):90-9. PMID: 16289751.
      View in: PubMed
    62. Varghese S, Gupta D, Baran T, Jiemjit A, Gore SD, Casero RA, Woster PM. Alkyl-substituted polyaminohydroxamic acids: a novel class of targeted histone deacetylase inhibitors. J Med Chem. 2005 Oct 06; 48(20):6350-65. PMID: 16190761.
      View in: PubMed
    63. Pledgie A, Huang Y, Hacker A, Zhang Z, Woster PM, Davidson NE, Casero RA. Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines. J Biol Chem. 2005 Dec 02; 280(48):39843-51. PMID: 16207710.
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    64. Huang Y, Pledgie A, Rubin E, Marton LJ, Woster PM, Sukumar S, Casero RA, Davidson NE. Role of p53/p21(Waf1/Cip1) in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells. Cancer Biol Ther. 2005 Sep; 4(9):1006-13. PMID: 16131835.
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    65. Vyas PM, Roychowdhury S, Woster PM, Svensson CK. Reactive oxygen species generation and its role in the differential cytotoxicity of the arylhydroxylamine metabolites of sulfamethoxazole and dapsone in normal human epidermal keratinocytes. Biochem Pharmacol. 2005 Jul 15; 70(2):275-86. PMID: 15894292.
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    66. Khomutov AR, Grigorenko NA, Demin AV, Vepsalainen J, Casero RA, Woster PM. [A charge-deficient analogue of spermine with chelating properties]. Bioorg Khim. 2005 May-Jun; 31(3):303-11. PMID: 16004389.
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    67. Wang Y, Hacker A, Murray-Stewart T, Frydman B, Valasinas A, Fraser AV, Woster PM, Casero RA. Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity. Cancer Chemother Pharmacol. 2005 Jul; 56(1):83-90. PMID: 15791459.
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    68. Wang Y, Hacker A, Murray-Stewart T, Fleischer JG, Woster PM, Casero RA. Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA synthesis, mRNA stabilization and newly synthesized protein. Biochem J. 2005 Mar 15; 386(Pt 3):543-7. PMID: 15496143.
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    69. Casero RA, Frydman B, Stewart TM, Woster PM. Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues. Proc West Pharmacol Soc. 2005; 48:24-30. PMID: 16416654.
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    70. Goosen TC, Cillié D, Bailey DG, Yu C, He K, Hollenberg PF, Woster PM, Cohen L, Williams JA, Rheeders M, Dijkstra HP. Bergamottin contribution to the grapefruit juice-felodipine interaction and disposition in humans. Clin Pharmacol Ther. 2004 Dec; 76(6):607-17. PMID: 15592332.
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    71. Bacchi CJ, Rattendi D, Faciane E, Yarlett N, Weiss LM, Frydman B, Woster P, Wei B, Marton LJ, Wittner M. Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues. Microbiology. 2004 May; 150(Pt 5):1215-1224. PMID: 15133083.
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    72. Ndjonka D, Zou Y, Bi X, Woster P, Walter RD, Lüersen K. The activator-binding site of Onchocerca volvulus S-adenosylmethionine decarboxylase, a potential drug target. Biol Chem. 2003 Aug; 384(8):1195-201. PMID: 12974388.
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    73. Devereux W, Wang Y, Stewart TM, Hacker A, Smith R, Frydman B, Valasinas AL, Reddy VK, Marton LJ, Ward TD, Woster PM, Casero RA. Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells. Cancer Chemother Pharmacol. 2003 Nov; 52(5):383-90. PMID: 12827295.
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    74. Wang Y, Murray-Stewart T, Devereux W, Hacker A, Frydman B, Woster PM, Casero RA. Properties of purified recombinant human polyamine oxidase, PAOh1/SMO. Biochem Biophys Res Commun. 2003 May 16; 304(4):605-11. PMID: 12727196.
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    75. Casero RA, Wang Y, Stewart TM, Devereux W, Hacker A, Wang Y, Smith R, Woster PM. The role of polyamine catabolism in anti-tumour drug response. Biochem Soc Trans. 2003 Apr; 31(2):361-5. PMID: 12653639.
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    76. Fraser AV, Woster PM, Wallace HM. Induction of apoptosis in human leukaemic cells by IPENSpm, a novel polyamine analogue and anti-metabolite. Biochem J. 2002 Oct 01; 367(Pt 1):307-12. PMID: 12086584.
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    77. Carlisle DL, Devereux WL, Hacker A, Woster PM, Casero RA. Growth status significantly affects the response of human lung cancer cells to antitumor polyamine-analogue exposure. Clin Cancer Res. 2002 Aug; 8(8):2684-9. PMID: 12171901.
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    78. Lawson KR, Marek S, Linehan JA, Woster PM, Casero RA, Payne CM, Gerner EW. Detoxification of the polyamine analogue N1-ethyl-N11-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by polyamine oxidase. Clin Cancer Res. 2002 May; 8(5):1241-7. PMID: 12006544.
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    79. Wang Y, Devereux W, Woster PM, Casero RA. Cloning and characterization of the mouse polyamine-modulated factor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor. Biochem J. 2001 Oct 15; 359(Pt 2):387-92. PMID: 11583586.
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    80. Wang Y, Devereux W, Woster PM, Stewart TM, Hacker A, Casero RA. Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure. Cancer Res. 2001 Jul 15; 61(14):5370-3. PMID: 11454677.
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    81. Zou Y, Wu Z, Sirisoma N, Woster PM, Casero RA, Weiss LM, Rattendi D, Lane S, Bacchi CJ. Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity. Bioorg Med Chem Lett. 2001 Jun 18; 11(12):1613-7. PMID: 11412992.
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    82. Hahm HA, Dunn VR, Butash KA, Deveraux WL, Woster PM, Casero RA, Davidson NE. Combination of standard cytotoxic agents with polyamine analogues in the treatment of breast cancer cell lines. Clin Cancer Res. 2001 Feb; 7(2):391-9. PMID: 11234895.
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    83. Casero RA, Woster PM. Terminally alkylated polyamine analogues as chemotherapeutic agents. J Med Chem. 2001 Jan 04; 44(1):1-26. PMID: 11141084.
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    84. Reilly TP, Lash LH, Doll MA, Hein DW, Woster PM, Svensson CK. A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions. J Invest Dermatol. 2000 Jun; 114(6):1164-73. PMID: 10844561.
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    85. Iyer R, Wu Z, Woster PM, Delcour AH. Molecular basis for the polyamine-ompF porin interactions: inhibitor and mutant studies. J Mol Biol. 2000 Apr 07; 297(4):933-45. PMID: 10736228.
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    86. Nairn LM, Lindsay GS, Woster PM, Wallace HM. Cytotoxicity of novel unsymmetrically substituted inhibitors of polyamine biosynthesis in human cancer cells. J Cell Physiol. 2000 Feb; 182(2):209-13. PMID: 10623884.
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    87. McCloskey DE, Woster PM, Casero RA, Davidson NE. Effects of the polyamine analogues N1-ethyl-N11-((cyclopropyl)methyl)-4,8-diazaundecane and N1-ethylN-11-((cycloheptyl)methyl)-4,8-diazaundecane in human prostate cancer cells. Clin Cancer Res. 2000 Jan; 6(1):17-23. PMID: 10656427.
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    88. Reilly TP, MacArthur RD, Farrough MJ, Crane LR, Woster PM, Svensson CK. Is hydroxylamine-induced cytotoxicity a valid marker for hypersensitivity reactions to sulfamethoxazole in human immunodeficiency virus-infected individuals? J Pharmacol Exp Ther. 1999 Dec; 291(3):1356-64. PMID: 10565861.
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    89. Webb HK, Wu Z, Sirisoma N, Ha HC, Casero RA, Woster PM. 1-(N-alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes: simple synthetic polyamine analogues that differentially alter tubulin polymerization. J Med Chem. 1999 Apr 22; 42(8):1415-21. PMID: 10212127.
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    90. Edwards DJ, Fitzsimmons ME, Schuetz EG, Yasuda K, Ducharme MP, Warbasse LH, Woster PM, Schuetz JD, Watkins P. 6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Clin Pharmacol Ther. 1999 Mar; 65(3):237-44. PMID: 10096255.
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    91. Davidson NE, Hahm HA, McCloskey DE, Woster PM, Casero RA. Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment. Endocr Relat Cancer. 1999 Mar; 6(1):69-73. PMID: 10732790.
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    92. Reilly TP, Woster PM, Svensson CK. Methemoglobin formation by hydroxylamine metabolites of sulfamethoxazole and dapsone: implications for differences in adverse drug reactions. J Pharmacol Exp Ther. 1999 Mar; 288(3):951-9. PMID: 10027831.
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    93. Nairn LM, Woster PM, Lindsay GS, Wallace HM. Comparison of polyamine analogue toxicity in two cell lines (HL-60 & MCF-7). Biochem Soc Trans. 1998 Nov; 26(4):S371. PMID: 10047885.
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    94. Ha HC, Sirisoma NS, Kuppusamy P, Zweier JL, Woster PM, Casero RA. The natural polyamine spermine functions directly as a free radical scavenger. Proc Natl Acad Sci U S A. 1998 Sep 15; 95(19):11140-5. PMID: 9736703.
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    95. Ha HC, Woster PM, Casero RA. Unsymmetrically substituted polyamine analogue induces caspase-independent programmed cell death in Bcl-2-overexpressing cells. Cancer Res. 1998 Jul 01; 58(13):2711-4. PMID: 9661878.
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    96. Reilly TP, Bellevue FH, Woster PM, Svensson CK. Comparison of the in vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone. Biochem Pharmacol. 1998 Mar 15; 55(6):803-10. PMID: 9586952.
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    97. Ha HC, Yager JD, Woster PA, Casero RA. Structural specificity of polyamines and polyamine analogues in the protection of DNA from strand breaks induced by reactive oxygen species. Biochem Biophys Res Commun. 1998 Mar 06; 244(1):298-303. PMID: 9514920.
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    98. Schmiedlin-Ren P, Edwards DJ, Fitzsimmons ME, He K, Lown KS, Woster PM, Rahman A, Thummel KE, Fisher JM, Hollenberg PF, Watkins PB. Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins. Drug Metab Dispos. 1997 Nov; 25(11):1228-33. PMID: 9351897.
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    99. Ha HC, Woster PM, Yager JD, Casero RA. The role of polyamine catabolism in polyamine analogue-induced programmed cell death. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11557-62. PMID: 9326648.
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    100. Edwards DJ, Bellevue FH, Woster PM. Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice. Drug Metab Dispos. 1996 Dec; 24(12):1287-90. PMID: 8971132.
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    101. Wu R, Saab NH, Huang H, Wiest L, Pegg AE, Casero RA, Woster PM. Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase. Bioorg Med Chem. 1996 Jun; 4(6):825-36. PMID: 8818232.
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    102. McCloskey DE, Yang J, Woster PM, Davidson NE, Casero RA. Polyamine analogue induction of programmed cell death in human lung tumor cells. Clin Cancer Res. 1996 Mar; 2(3):441-6. PMID: 9816189.
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    103. Felschow DM, MacDiarmid J, Bardos T, Wu R, Woster PM, Porter CW. Photoaffinity labeling of a cell surface polyamine binding protein. J Biol Chem. 1995 Dec 01; 270(48):28705-11. PMID: 7499391.
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    104. McCloskey DE, Casero RA, Woster PM, Davidson NE. Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue. Cancer Res. 1995 Aug 01; 55(15):3233-6. PMID: 7614453.
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    105. Guo J, Wu YQ, Rattendi D, Bacchi CJ, Woster PM. S-(5'-deoxy-5'-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene (AdoMao): an irreversible inhibitor of S-adenosylmethionine decarboxylase with potent in vitro antitrypanosomal activity. J Med Chem. 1995 May 12; 38(10):1770-7. PMID: 7752200.
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    106. Wu YQ, Woster PM. Irreversible inhibition of human S-adenosylmethionine decarboxylase by the pure diastereomeric forms of S-(5'-deoxy-5'-adenosyl)-1-ammonio-4- methylsulfonio-2-cyclopentene (AdoMac). Biochem Pharmacol. 1995 Apr 18; 49(8):1125-33. PMID: 7748194.
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    107. Casero RA, Mank AR, Saab NH, Wu R, Dyer WJ, Woster PM. Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1. Cancer Chemother Pharmacol. 1995; 36(1):69-74. PMID: 7720179.
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    108. Vage C, Saab N, Woster PM, Svensson CK. Dapsone-induced hematologic toxicity: comparison of the methemoglobin-forming ability of hydroxylamine metabolites of dapsone in rat and human blood. Toxicol Appl Pharmacol. 1994 Dec; 129(2):309-16. PMID: 7992320.
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    109. Wu YQ, Woster PM. Preparation of the pure diastereomeric forms of S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopentene and their evaluation as irreversible inhibitors of S-adenosylmethionine decarboxylase from Escherichia coli. Bioorg Med Chem. 1993 Nov; 1(5):349-60. PMID: 8081865.
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    110. Saab NH, West EE, Bieszk NC, Preuss CV, Mank AR, Casero RA, Woster PM. Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents. J Med Chem. 1993 Oct 01; 36(20):2998-3004. PMID: 8411017.
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    111. Wu Y, Woster PM. S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-(methylsulfonio)-2-cyclopentene: A potent, enzyme-activated irreversible inhibitor of S-adenosylmethionine decarboxylase. J Med Chem. 1992 Aug 21; 35(17):3196-201. PMID: 1507205.
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    112. Pegg AE, Wechter R, Poulin R, Woster PM, Coward JK. Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells. Biochemistry. 1989 Oct 17; 28(21):8446-53. PMID: 2605194.
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    113. Woster PM, Black AY, Duff KJ, Coward JK, Pegg AE. Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase. J Med Chem. 1989 Jun; 32(6):1300-7. PMID: 2724300.
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    114. Woster PM, Murray WJ. Synthesis and biological evaluation of cyclic analogues of 1-carnitine as potential agents in the treatment of myocardial ischemia. J Med Chem. 1986 May; 29(5):865-8. PMID: 3084787.
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