Keywords
Last Name
Institution

Patrick J. Mulholland

Title
InstitutionMedical University of South Carolina
DepartmentNeuroscience
AddressP.O. Box MSC 861
629 C
Thurmond Gazes - 30 Courtenay Drive
Phone843-792-1229
Fax843-792-7353
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Haun HL, Griffin WC, Lopez MF, Solomon MG, Mulholland PJ, Woodward JJ, McGinty JF, Ron D, Becker HC. Increasing Brain-Derived Neurotrophic Factor (BDNF) in medial prefrontal cortex selectively reduces excessive drinking in ethanol dependent mice. Neuropharmacology. 2018 09 15; 140:35-42. PMID: 30056122.
      View in: PubMed
    2. McGuier NS, Rinker JA, Cannady R, Fulmer DB, Jones SR, Hoffman M, Mulholland PJ. Identification and validation of midbrain Kcnq4 regulation of heavy alcohol consumption in rodents. Neuropharmacology. 2018 08; 138:10-19. PMID: 29775679.
      View in: PubMed
    3. Mulholland PJ, Teppen TL, Miller KM, Sexton HG, Pandey SC, Swartzwelder HS. Donepezil Reverses Dendritic Spine Morphology Adaptations and Fmr1 Epigenetic Modifications in Hippocampus of Adult Rats After Adolescent Alcohol Exposure. Alcohol Clin Exp Res. 2018 Apr; 42(4):706-717. PMID: 29336496.
      View in: PubMed
    4. Cannady R, Rinker JA, Nimitvilai S, Woodward JJ, Mulholland PJ. Correction to: Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior. Handb Exp Pharmacol. 2018; 248:619. PMID: 30810861.
      View in: PubMed
    5. Cannady R, Rinker JA, Nimitvilai S, Woodward JJ, Mulholland PJ. Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior. Handb Exp Pharmacol. 2018; 248:311-343. PMID: 29374839.
      View in: PubMed
    6. Rinker JA, Mulholland PJ. Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models. Pharmacogenomics. 2017 Apr; 18(6):555-570. PMID: 28346058.
      View in: PubMed
    7. Cannady R, McGonigal JT, Newsom RJ, Woodward JJ, Mulholland PJ, Gass JT. Prefrontal Cortex KCa2 Channels Regulate mGlu5-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior. J Neurosci. 2017 04 19; 37(16):4359-4369. PMID: 28320841.
      View in: PubMed
    8. Nimitvilai S, Uys JD, Woodward JJ, Randall PK, Ball LE, Williams RW, Jones BC, Lu L, Grant KA, Mulholland PJ. Orbitofrontal Neuroadaptations and Cross-Species Synaptic Biomarkers in Heavy-Drinking Macaques. J Neurosci. 2017 03 29; 37(13):3646-3660. PMID: 28270566.
      View in: PubMed
    9. den Hartog CR, Gilstrap M, Eaton B, Lench DH, Mulholland PJ, Homanics GE, Woodward JJ. Effects of Repeated Ethanol Exposures on NMDA Receptor Expression and Locomotor Sensitization in Mice Expressing Ethanol Resistant NMDA Receptors. Front Neurosci. 2017; 11:84. PMID: 28270746.
      View in: PubMed
    10. Nimitvilai S, Lopez MF, Mulholland PJ, Woodward JJ. Ethanol Dependence Abolishes Monoamine and GIRK (Kir3) Channel Inhibition of Orbitofrontal Cortex Excitability. Neuropsychopharmacology. 2017 Aug; 42(9):1800-1812. PMID: 28139680.
      View in: PubMed
    11. Trantham-Davidson H, Centanni SW, Garr SC, New NN, Mulholland PJ, Gass JT, Glover EJ, Floresco SB, Crews FT, Krishnan HR, Pandey SC, Chandler LJ. Binge-Like Alcohol Exposure During Adolescence Disrupts Dopaminergic Neurotransmission in the Adult Prelimbic Cortex. Neuropsychopharmacology. 2017 Apr; 42(5):1024-1036. PMID: 27620551.
      View in: PubMed
    12. Rinker JA, Fulmer DB, Trantham-Davidson H, Smith ML, Williams RW, Lopez MF, Randall PK, Chandler LJ, Miles MF, Becker HC, Mulholland PJ. Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking. Alcohol. 2017 Feb; 58:33-45. PMID: 27432260.
      View in: PubMed
    13. Mulholland PJ, Chandler LJ, Kalivas PW. Signals from the Fourth Dimension Regulate Drug Relapse. Trends Neurosci. 2016 07; 39(7):472-485. PMID: 27173064.
      View in: PubMed
    14. Spencer KB, Mulholland PJ, Chandler LJ. FMRP Mediates Chronic Ethanol-Induced Changes in NMDA, Kv4.2, and KChIP3 Expression in the Hippocampus. Alcohol Clin Exp Res. 2016 06; 40(6):1251-61. PMID: 27147118.
      View in: PubMed
    15. Nimitvilai S, Lopez MF, Mulholland PJ, Woodward JJ. Chronic Intermittent Ethanol Exposure Enhances the Excitability and Synaptic Plasticity of Lateral Orbitofrontal Cortex Neurons and Induces a Tolerance to the Acute Inhibitory Actions of Ethanol. Neuropsychopharmacology. 2016 Mar; 41(4):1112-27. PMID: 26286839.
      View in: PubMed
    16. McGuier NS, Griffin WC, Gass JT, Padula AE, Chesler EJ, Mulholland PJ. Kv7 channels in the nucleus accumbens are altered by chronic drinking and are targets for reducing alcohol consumption. Addict Biol. 2016 11; 21(6):1097-1112. PMID: 26104325.
      View in: PubMed
    17. Samantaray S, Knaryan VH, Patel KS, Mulholland PJ, Becker HC, Banik NL. Chronic intermittent ethanol induced axon and myelin degeneration is attenuated by calpain inhibition. Brain Res. 2015 Oct 05; 1622:7-21. PMID: 26100335.
      View in: PubMed
    18. Uys JD, McGuier NS, Gass JT, Griffin WC, Ball LE, Mulholland PJ. Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines. Addict Biol. 2016 May; 21(3):560-74. PMID: 25787124.
      View in: PubMed
    19. McGuier NS, Padula AE, Mulholland PJ, Chandler LJ. Homer2 deletion alters dendritic spine morphology but not alcohol-associated adaptations in GluN2B-containing N-methyl-D-aspartate receptors in the nucleus accumbens. Front Pharmacol. 2015; 6:28. PMID: 25755642.
      View in: PubMed
    20. Padula AE, Griffin WC, Lopez MF, Nimitvilai S, Cannady R, McGuier NS, Chesler EJ, Miles MF, Williams RW, Randall PK, Woodward JJ, Becker HC, Mulholland PJ. KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. Neuropsychopharmacology. 2015 Jul; 40(8):1928-39. PMID: 25662840.
      View in: PubMed
    21. Mulholland PJ, Spencer KB, Hu W, Kroener S, Chandler LJ. Neuroplasticity of A-type potassium channel complexes induced by chronic alcohol exposure enhances dendritic calcium transients in hippocampus. Psychopharmacology (Berl). 2015 Jun; 232(11):1995-2006. PMID: 25510858.
      View in: PubMed
    22. McGuier NS, Padula AE, Lopez MF, Woodward JJ, Mulholland PJ. Withdrawal from chronic intermittent alcohol exposure increases dendritic spine density in the lateral orbitofrontal cortex of mice. Alcohol. 2015 Feb; 49(1):21-7. PMID: 25468278.
      View in: PubMed
    23. Centanni SW, Teppen T, Risher ML, Fleming RL, Moss JL, Acheson SK, Mulholland PJ, Pandey SC, Chandler LJ, Swartzwelder HS. Adolescent alcohol exposure alters GABAA receptor subunit expression in adult hippocampus. Alcohol Clin Exp Res. 2014 Nov; 38(11):2800-8. PMID: 25421517.
      View in: PubMed
    24. Uys JD, Mulholland PJ, Townsend DM. Glutathione and redox signaling in substance abuse. Biomed Pharmacother. 2014 Jul; 68(6):799-807. PMID: 25027386.
      View in: PubMed
    25. Trantham-Davidson H, Burnett EJ, Gass JT, Lopez MF, Mulholland PJ, Centanni SW, Floresco SB, Chandler LJ. Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex. J Neurosci. 2014 Mar 05; 34(10):3706-18. PMID: 24599469.
      View in: PubMed
    26. Becker HC, Mulholland PJ. Neurochemical mechanisms of alcohol withdrawal. Handb Clin Neurol. 2014; 125:133-56. PMID: 25307573.
      View in: PubMed
    27. Konadhode RR, Pelluru D, Blanco-Centurion C, Zayachkivsky A, Liu M, Uhde T, Glen WB, van den Pol AN, Mulholland PJ, Shiromani PJ. Optogenetic stimulation of MCH neurons increases sleep. J Neurosci. 2013 Jun 19; 33(25):10257-63. PMID: 23785141.
      View in: PubMed
    28. Badanich KA, Mulholland PJ, Beckley JT, Trantham-Davidson H, Woodward JJ. Ethanol reduces neuronal excitability of lateral orbitofrontal cortex neurons via a glycine receptor dependent mechanism. Neuropsychopharmacology. 2013 Jun; 38(7):1176-88. PMID: 23314219.
      View in: PubMed
    29. Jung Y, Mulholland PJ, Wiseman SL, Chandler LJ, Picciotto MR. Constitutive knockout of the membrane cytoskeleton protein beta adducin decreases mushroom spine density in the nucleus accumbens but does not prevent spine remodeling in response to cocaine. Eur J Neurosci. 2013 Jan; 37(1):1-9. PMID: 23106536.
      View in: PubMed
    30. Mulholland PJ, Jordan BA, Chandler LJ. Chronic ethanol up-regulates the synaptic expression of the nuclear translational regulatory protein AIDA-1 in primary hippocampal neurons. Alcohol. 2012 Sep; 46(6):569-76. PMID: 22703994.
      View in: PubMed
    31. Kroener S, Mulholland PJ, New NN, Gass JT, Becker HC, Chandler LJ. Chronic alcohol exposure alters behavioral and synaptic plasticity of the rodent prefrontal cortex. PLoS One. 2012; 7(5):e37541. PMID: 22666364.
      View in: PubMed
    32. Roberto M, Kash TL, Mulholland PJ, Marty VN, Gilpin NW, Walker BM. Introduction to Young Investigator Award Symposium: Symposium XII: Young Investigator Award. Alcohol. 2012 Jun; 46(4):301-2. PMID: 22541586.
      View in: PubMed
    33. Mulholland PJ. K(Ca)2 channels: novel therapeutic targets for treating alcohol withdrawal and escalation of alcohol consumption. Alcohol. 2012 Jun; 46(4):309-15. PMID: 22464787.
      View in: PubMed
    34. Prendergast MA, Mulholland PJ. Glucocorticoid and polyamine interactions in the plasticity of glutamatergic synapses that contribute to ethanol-associated dependence and neuronal injury. Addict Biol. 2012 Mar; 17(2):209-23. PMID: 21967628.
      View in: PubMed
    35. Badanich KA, Doremus-Fitzwater TL, Mulholland PJ, Randall PK, Delpire E, Becker HC. NR2B-deficient mice are more sensitive to the locomotor stimulant and depressant effects of ethanol. Genes Brain Behav. 2011 Oct; 10(7):805-816. PMID: 21762461.
      View in: PubMed
    36. Pava MJ, Blake EM, Green ST, Mizroch BJ, Mulholland PJ, Woodward JJ. Tolerance to cannabinoid-induced behaviors in mice treated chronically with ethanol. Psychopharmacology (Berl). 2012 Jan; 219(1):137-47. PMID: 21701813.
      View in: PubMed
    37. Gorelova N, Mulholland PJ, Chandler LJ, Seamans JK. The glutamatergic component of the mesocortical pathway emanating from different subregions of the ventral midbrain. Cereb Cortex. 2012 Feb; 22(2):327-36. PMID: 21666135.
      View in: PubMed
    38. Lutz BD, Bernhardt ES, Roberts BJ, Mulholland PJ. Examining the coupling of carbon and nitrogen cycles in Appalachian streams: the role of dissolved organic nitrogen. Ecology. 2011 Mar; 92(3):720-32. PMID: 21608480.
      View in: PubMed
    39. Beaulieu JJ, Tank JL, Hamilton SK, Wollheim WM, Hall RO, Mulholland PJ, Peterson BJ, Ashkenas LR, Cooper LW, Dahm CN, Dodds WK, Grimm NB, Johnson SL, McDowell WH, Poole GC, Valett HM, Arango CP, Bernot MJ, Burgin AJ, Crenshaw CL, Helton AM, Johnson LT, O'Brien JM, Potter JD, Sheibley RW, Sobota DJ, Thomas SM. Nitrous oxide emission from denitrification in stream and river networks. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):214-9. PMID: 21173258.
      View in: PubMed
    40. Mulholland PJ, Becker HC, Woodward JJ, Chandler LJ. Small conductance calcium-activated potassium type 2 channels regulate alcohol-associated plasticity of glutamatergic synapses. Biol Psychiatry. 2011 Apr 01; 69(7):625-32. PMID: 21056409.
      View in: PubMed
    41. Mulholland PJ, Chandler LJ. Inhibition of glutamate transporters couples to Kv4.2 dephosphorylation through activation of extrasynaptic NMDA receptors. Neuroscience. 2010 Jan 13; 165(1):130-7. PMID: 19850106.
      View in: PubMed
    42. Mulholland PJ, Hopf FW, Bukiya AN, Martin GE, Liu J, Dopico AM, Bonci A, Treistman SN, Chandler LJ. Sizing up ethanol-induced plasticity: the role of small and large conductance calcium-activated potassium channels. Alcohol Clin Exp Res. 2009 Jul; 33(7):1125-35. PMID: 19389201.
      View in: PubMed
    43. Mulholland PJ, Carpenter-Hyland EP, Woodward JJ, Chandler LJ. Ethanol disrupts NMDA receptor and astroglial EAAT2 modulation of Kv2.1 potassium channels in hippocampus. Alcohol. 2009 Feb; 43(1):45-50. PMID: 19185209.
      View in: PubMed
    44. Jacquot C, Croft AP, Prendergast MA, Mulholland P, Shaw SG, Little HJ. Effects of the glucocorticoid antagonist, mifepristone, on the consequences of withdrawal from long term alcohol consumption. Alcohol Clin Exp Res. 2008 Dec; 32(12):2107-16. PMID: 18828802.
      View in: PubMed
    45. Mulholland PJ, Carpenter-Hyland EP, Hearing MC, Becker HC, Woodward JJ, Chandler LJ. Glutamate transporters regulate extrasynaptic NMDA receptor modulation of Kv2.1 potassium channels. J Neurosci. 2008 Aug 27; 28(35):8801-9. PMID: 18753382.
      View in: PubMed
    46. Barron S, Mulholland PJ, Littleton JM, Prendergast MA. Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures. Alcohol Clin Exp Res. 2008 Jun; 32(6):929-36. PMID: 18445110.
      View in: PubMed
    47. Mulholland PJ, Luong NT, Woodward JJ, Chandler LJ. Brain-derived neurotrophic factor activation of extracellular signal-regulated kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular signal-regulated kinase shutoff pathway. Neuroscience. 2008 Jan 24; 151(2):419-27. PMID: 18055129.
      View in: PubMed
    48. Mulholland PJ, Chandler LJ. The thorny side of addiction: adaptive plasticity and dendritic spines. ScientificWorldJournal. 2007 Nov 02; 7:9-21. PMID: 17982573.
      View in: PubMed
    49. Mulholland PJ, Self RL, Hensley AK, Little HJ, Littleton JM, Prendergast MA. A 24 h corticosterone exposure exacerbates excitotoxic insult in rat hippocampal slice cultures independently of glucocorticoid receptor activation or protein synthesis. Brain Res. 2006 Apr 12; 1082(1):165-72. PMID: 16510135.
      View in: PubMed
    50. Mulholland PJ. Susceptibility of the cerebellum to thiamine deficiency. Cerebellum. 2006; 5(1):55-63. PMID: 16527765.
      View in: PubMed
    51. Self RL, Smith KJ, Mulholland PJ, Prendergast MA. Ethanol exposure and withdrawal sensitizes the rat hippocampal CA1 pyramidal cell region to beta-amyloid (25-35)-induced cytotoxicity: NMDA receptor involvement. Alcohol Clin Exp Res. 2005 Nov; 29(11):2063-9. PMID: 16340465.
      View in: PubMed
    52. Mulholland PJ, Stepanyan TD, Self RL, Hensley AK, Harris BR, Kowalski A, Littleton JM, Prendergast MA. Corticosterone and dexamethasone potentiate cytotoxicity associated with oxygen-glucose deprivation in organotypic cerebellar slice cultures. Neuroscience. 2005; 136(1):259-67. PMID: 16182452.
      View in: PubMed
    53. Mulholland PJ, Self RL, Stepanyan TD, Little HJ, Littleton JM, Prendergast MA. Thiamine deficiency in the pathogenesis of chronic ethanol-associated cerebellar damage in vitro. Neuroscience. 2005; 135(4):1129-39. PMID: 16165302.
      View in: PubMed
    54. Mulholland PJ, Self RL, Harris BR, Little HJ, Littleton JM, Prendergast MA. Corticosterone increases damage and cytosolic calcium accumulation associated with ethanol withdrawal in rat hippocampal slice cultures. Alcohol Clin Exp Res. 2005 May; 29(5):871-81. PMID: 15897733.
      View in: PubMed
    55. Self RL, Mulholland PJ, Harris BR, Nath A, Prendergast MA. Cytotoxic effects of exposure to the human immunodeficiency virus type 1 protein Tat in the hippocampus are enhanced by prior ethanol treatment. Alcohol Clin Exp Res. 2004 Dec; 28(12):1916-24. PMID: 15608609.
      View in: PubMed
    56. Mulholland PJ, Self RL, Harris BR, Littleton JM, Prendergast MA. Choline exposure reduces potentiation of N-methyl-D-aspartate toxicity by corticosterone in the developing hippocampus. Brain Res Dev Brain Res. 2004 Nov 25; 153(2):203-11. PMID: 15527888.
      View in: PubMed
    57. Self RL, Mulholland PJ, Nath A, Harris BR, Prendergast MA. The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive site. Brain Res. 2004 Jan 02; 995(1):39-45. PMID: 14644469.
      View in: PubMed
    58. Mulholland PJ, Harris BR, Wilkins LH, Self RL, Blanchard JA, Holley RC, Littleton JM, Prendergast MA. Opposing effects of ethanol and nicotine on hippocampal calbindin-D28k expression. Alcohol. 2003 Aug-Oct; 31(1-2):1-10. PMID: 14615005.
      View in: PubMed
    59. Mulholland PJ, Prendergast MA. Transection of intrinsic polysynaptic pathways reduces N-methyl-D-aspartate neurotoxicity in hippocampal slice cultures. Neurosci Res. 2003 Jul; 46(3):369-76. PMID: 12804798.
      View in: PubMed
    60. Prendergast MA, Rogers DT, Mulholland PJ, Littleton JM, Wilkins LH, Self RL, Nath A. Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor. Brain Res. 2002 Nov 08; 954(2):300-7. PMID: 12414113.
      View in: PubMed
    61. Mulholland PJ, Prendergast MA. Post-insult exposure to (+/-) kavain potentiates N-methyl-D-aspartate toxicity in the developing hippocampus. Brain Res. 2002 Jul 26; 945(1):106-13. PMID: 12113957.
      View in: PubMed
    62. Steinman AD, Mulholland PJ, Palumbo AV, DeAngelis DL, Flum TE. Lotic Ecosystem Response to a Chlorine Disturbance. Ecol Appl. 1992 Nov; 2(4):341-355. PMID: 27759274.
      View in: PubMed
    63. Mulholland PJ, Newbold JD, Elwood JW, Hom CL. The effect of grazing intensity on phosphorus spiralling in autotropic streams. Oecologia. 1983 Jun; 58(3):358-366. PMID: 28310335.
      View in: PubMed
    Mulholland's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _