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P. Darwin Bell

Title
InstitutionMedical University of South Carolina
DepartmentNephrology
AddressP.O. Box MSC 629
DDB 514
70 President St.
Phone843-876-2372
Fax843-792-5521
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    Kidney

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Saigusa T, Yue Q, Bunni MA, Bell PD, Eaton DC. Loss of primary cilia increases polycystin-2 and TRPV4 and the appearance of a nonselective cation channel in the mouse cortical collecting duct. Am J Physiol Renal Physiol. 2019 Sep 01; 317(3):F632-F637. PMID: 31313950.
      View in: PubMed
    2. Chumley P, Zhou J, Mrug S, Chacko B, Parant JM, Challa AK, Wilson LS, Berryhill TF, Barnes S, Kesterson RA, Bell PD, Darley-Usmar VM, Yoder BK, Mrug M. Truncating PKHD1 and PKD2 mutations alter energy metabolism. Am J Physiol Renal Physiol. 2019 03 01; 316(3):F414-F425. PMID: 30566001.
      View in: PubMed
    3. Neely BA, Soper JL, Gulland FM, Bell PD, Kindy M, Arthur JM, Janech MG. Proteomic analysis of cerebrospinal fluid in California sea lions (Zalophus californianus) with domoic acid toxicosis identifies proteins associated with neurodegeneration. Proteomics. 2015 Dec; 15(23-24):4051-63. PMID: 26364553.
      View in: PubMed
    4. Saigusa T, Dang Y, Mullick AE, Yeh ST, Zile MR, Baicu CF, Bell PD. Suppressing angiotensinogen synthesis attenuates kidney cyst formation in a Pkd1 mouse model. FASEB J. 2016 Jan; 30(1):370-9. PMID: 26391272.
      View in: PubMed
    5. Hwang VJ, Kim J, Rand A, Yang C, Sturdivant S, Hammock B, Bell PD, Guay-Woodford LM, Weiss RH. The cpk model of recessive PKD shows glutamine dependence associated with the production of the oncometabolite 2-hydroxyglutarate. Am J Physiol Renal Physiol. 2015 Sep 15; 309(6):F492-8. PMID: 26155843.
      View in: PubMed
    6. Saigusa T, Bell PD. Molecular pathways and therapies in autosomal-dominant polycystic kidney disease. Physiology (Bethesda). 2015 May; 30(3):195-207. PMID: 25933820.
      View in: PubMed
    7. Saigusa T, Dang Y, Bunni MA, Amria MY, Steele SL, Fitzgibbon WR, Bell PD. Activation of the intrarenal renin-angiotensin-system in murine polycystic kidney disease. Physiol Rep. 2015 May; 3(5). PMID: 25999403.
      View in: PubMed
    8. Bell PD. Perspectives: From Bedside to Bench. Am J Physiol Renal Physiol. 2015 Jul 01; 309(1):F1. PMID: 25925256.
      View in: PubMed
    9. Sas KM, Yin H, Fitzgibbon WR, Baicu CF, Zile MR, Steele SL, Amria M, Saigusa T, Funk J, Bunni MA, Siegal GP, Siroky BJ, Bissler JJ, Bell PD. Hyperglycemia in the absence of cilia accelerates cystogenesis and induces renal damage. Am J Physiol Renal Physiol. 2015 Jul 01; 309(1):F79-87. PMID: 25904703.
      View in: PubMed
    10. Gudi R, Haycraft CJ, Bell PD, Li Z, Vasu C. Centrobin-mediated regulation of the centrosomal protein 4.1-associated protein (CPAP) level limits centriole length during elongation stage. J Biol Chem. 2015 Mar 13; 290(11):6890-902. PMID: 25616662.
      View in: PubMed
    11. Coaxum SD, Blanton MG, Joyner A, Akter T, Bell PD, Luttrell LM, Raymond JR, Lee MH, Blichmann PA, Garnovskaya MN, Saigusa T. Epidermal growth factor-induced proliferation of collecting duct cells from Oak Ridge polycystic kidney mice involves activation of Na+/H+ exchanger. Am J Physiol Cell Physiol. 2014 Sep 15; 307(6):C554-60. PMID: 25055824.
      View in: PubMed
    12. Siroky BJ, Yin H, Dixon BP, Reichert RJ, Hellmann AR, Ramkumar T, Tsuchihashi Z, Bunni M, Dillon J, Bell PD, Sampson JR, Bissler JJ. Evidence for pericyte origin of TSC-associated renal angiomyolipomas and implications for angiotensin receptor inhibition therapy. Am J Physiol Renal Physiol. 2014 Sep 01; 307(5):F560-70. PMID: 24920756.
      View in: PubMed
    13. Beck Gooz M, Maldonado EN, Dang Y, Amria MY, Higashiyama S, Abboud HE, Lemasters JJ, Bell PD. ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease. Am J Physiol Renal Physiol. 2014 Sep 01; 307(5):F551-9. PMID: 24899059.
      View in: PubMed
    14. Funk JA, Janech MG, Dillon JC, Bissler JJ, Siroky BJ, Bell PD. Characterization of renal toxicity in mice administered the marine biotoxin domoic Acid. J Am Soc Nephrol. 2014 Jun; 25(6):1187-97. PMID: 24511141.
      View in: PubMed
    15. Shi C, Cisewski SE, Bell PD, Yao H. Measurement of three-dimensional anisotropic diffusion by multiphoton fluorescence recovery after photobleaching. Ann Biomed Eng. 2014 Mar; 42(3):555-65. PMID: 24248560.
      View in: PubMed
    16. Gilley SK, Stenbit AE, Pasek RC, Sas KM, Steele SL, Amria M, Bunni MA, Estell KP, Schwiebert LM, Flume P, Gooz M, Haycraft CJ, Yoder BK, Miller C, Pavlik JA, Turner GA, Sisson JH, Bell PD. Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways. Am J Physiol Lung Cell Mol Physiol. 2014 Jan; 306(2):L162-9. PMID: 24213915.
      View in: PubMed
    17. Zhang ZR, Chu WF, Song B, Gooz M, Zhang JN, Yu CJ, Jiang S, Baldys A, Gooz P, Steele S, Owsianik G, Nilius B, Komlosi P, Bell PD. TRPP2 and TRPV4 form an EGF-activated calcium permeable channel at the apical membrane of renal collecting duct cells. PLoS One. 2013; 8(8):e73424. PMID: 23977387.
      View in: PubMed
    18. O'Connor AK, Malarkey EB, Berbari NF, Croyle MJ, Haycraft CJ, Bell PD, Hohenstein P, Kesterson RA, Yoder BK. An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue. Cilia. 2013 Jul 03; 2(1):8. PMID: 23819925.
      View in: PubMed
    19. Bell PD. Meet your new AJP-Renal Physiology editors. Am J Physiol Renal Physiol. 2013 Jul 01; 305(1):F1-2. PMID: 23678043.
      View in: PubMed
    20. Hossain A, Radwan FF, Doonan BP, God JM, Zhang L, Bell PD, Haque A. A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma. Apoptosis. 2012 Oct; 17(10):1066-78. PMID: 22847295.
      View in: PubMed
    21. Saigusa T, Reichert R, Guare J, Siroky BJ, Gooz M, Steele S, Fenton RA, Bell PD, Kolb RJ. Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors. Am J Physiol Renal Physiol. 2012 Apr 01; 302(7):F801-8. PMID: 22205228.
      View in: PubMed
    22. Bell PD, Fitzgibbon W, Sas K, Stenbit AE, Amria M, Houston A, Reichert R, Gilley S, Siegal GP, Bissler J, Bilgen M, Chou PC, Guay-Woodford L, Yoder B, Haycraft CJ, Siroky B. Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesis. J Am Soc Nephrol. 2011 May; 22(5):839-48. PMID: 21493775.
      View in: PubMed
    23. Fogelgren B, Lin SY, Zuo X, Jaffe KM, Park KM, Reichert RJ, Bell PD, Burdine RD, Lipschutz JH. The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes. PLoS Genet. 2011 Apr; 7(4):e1001361. PMID: 21490950.
      View in: PubMed
    24. Sproul A, Steele SL, Thai TL, Yu S, Klein JD, Sands JM, Bell PD. N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct. Am J Physiol Renal Physiol. 2011 Jul; 301(1):F44-54. PMID: 21429969.
      View in: PubMed
    25. Sas KM, Janech MG, Favre E, Arthur JM, Bell PD. Cilia movement regulates expression of the Raf-1 kinase inhibitor protein. Am J Physiol Renal Physiol. 2011 May; 300(5):F1163-70. PMID: 21345975.
      View in: PubMed
    26. Kleyman TR, Satlin LM, Bell PD, Garvin JL. The roles of mechanical forces in regulating tubular epithelial cell function and renal vasculature. Editors' note. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1219. PMID: 21139154.
      View in: PubMed
    27. Steele SL, Wu Y, Kolb RJ, Gooz M, Haycraft CJ, Keyser KT, Guay-Woodford L, Yao H, Bell PD. Telomerase immortalization of principal cells from mouse collecting duct. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1507-14. PMID: 20926633.
      View in: PubMed
    28. Shi C, Kuo J, Bell PD, Yao H. Anisotropic solute diffusion tensor in porcine TMJ discs measured by FRAP with spatial Fourier analysis. Ann Biomed Eng. 2010 Nov; 38(11):3398-408. PMID: 20582475.
      View in: PubMed
    29. Bell PD, Komlosi P, Zhang ZR. ATP as a mediator of macula densa cell signalling. Purinergic Signal. 2009 Dec; 5(4):461-71. PMID: 19330465.
      View in: PubMed
    30. Komlosi P, Banizs B, Fintha A, Steele S, Zhang ZR, Bell PD. Oscillating cortical thick ascending limb cells at the juxtaglomerular apparatus. J Am Soc Nephrol. 2008 Oct; 19(10):1940-6. PMID: 18562570.
      View in: PubMed
    31. Hovater MB, Olteanu D, Hanson EL, Cheng NL, Siroky B, Fintha A, Komlosi P, Liu W, Satlin LM, Bell PD, Yoder BK, Schwiebert EM. Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals. Purinergic Signal. 2008 Jun; 4(2):155-70. PMID: 18368523.
      View in: PubMed
    32. Komlosi P, Fintha A, Bell PD. Unraveling the relationship between macula densa cell volume and luminal solute concentration/osmolality. Kidney Int. 2006 Sep; 70(5):865-71. PMID: 16820788.
      View in: PubMed
    33. Siroky BJ, Ferguson WB, Fuson AL, Xie Y, Fintha A, Komlosi P, Yoder BK, Schwiebert EM, Guay-Woodford LM, Bell PD. Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells. Am J Physiol Renal Physiol. 2006 Jun; 290(6):F1320-8. PMID: 16396941.
      View in: PubMed
    34. Olteanu D, Yoder BK, Liu W, Croyle MJ, Welty EA, Rosborough K, Wyss JM, Bell PD, Guay-Woodford LM, Bevensee MO, Satlin LM, Schwiebert EM. Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia. Am J Physiol Cell Physiol. 2006 Apr; 290(4):C952-63. PMID: 16207792.
      View in: PubMed
    35. Komlosi P, Fintha A, Bell PD. Renal cell-to-cell communication via extracellular ATP. Physiology (Bethesda). 2005 Apr; 20:86-90. PMID: 15772296.
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    36. Kovacs GG, Zsembery A, Anderson SJ, Komlosi P, Gillespie GY, Bell PD, Benos DJ, Fuller CM. Changes in intracellular Ca2+ and pH in response to thapsigargin in human glioblastoma cells and normal astrocytes. Am J Physiol Cell Physiol. 2005 Aug; 289(2):C361-71. PMID: 15800052.
      View in: PubMed
    37. Swystun V, Chen L, Factor P, Siroky B, Bell PD, Matalon S. Apical trypsin increases ion transport and resistance by a phospholipase C-dependent rise of Ca2+. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L820-30. PMID: 15626748.
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    38. Komlosi P, Frische S, Fuson AL, Fintha A, Zsembery A, Peti-Peterdi J, Bell PD. Characterization of basolateral chloride/bicarbonate exchange in macula densa cells. Am J Physiol Renal Physiol. 2005 Feb; 288(2):F380-6. PMID: 15479854.
      View in: PubMed
    39. Komlosi P, Fintha A, Bell PD. Current mechanisms of macula densa cell signalling. Acta Physiol Scand. 2004 Aug; 181(4):463-9. PMID: 15283759.
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    40. Williams I, Williams C, Siroky B, Bates E, Kovacs G, Peti-Peterdi J, Unlap MT, Bell PD. Regulation of mesangial cell Na+/Ca2+ exchanger isoforms. J Cell Physiol. 2004 May; 199(2):181-93. PMID: 15040000.
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    41. Kovács G, Komlósi P, Fuson A, Peti-Peterdi J, Rosivall L, Bell PD. Neuronal nitric oxide synthase: its role and regulation in macula densa cells. J Am Soc Nephrol. 2003 Oct; 14(10):2475-83. PMID: 14514725.
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    42. Unlap MT, Bates E, Williams C, Komlosi P, Williams I, Kovacs G, Siroky B, Bell PD. Na+/Ca2+ exchanger: target for oxidative stress in salt-sensitive hypertension. Hypertension. 2003 Sep; 42(3):363-8. PMID: 12885789.
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    43. Peti-Peterdi J, Komlosi P, Fuson AL, Guan Y, Schneider A, Qi Z, Redha R, Rosivall L, Breyer MD, Bell PD. Luminal NaCl delivery regulates basolateral PGE2 release from macula densa cells. J Clin Invest. 2003 Jul; 112(1):76-82. PMID: 12840061.
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    44. Fuson AL, Komlosi P, Unlap TM, Bell PD, Peti-Peterdi J. Immunolocalization of a microsomal prostaglandin E synthase in rabbit kidney. Am J Physiol Renal Physiol. 2003 Sep; 285(3):F558-64. PMID: 12746259.
      View in: PubMed
    45. Lapointe JY, Bell PD, Sabirov RZ, Okada Y. Calcium-activated nonselective cationic channel in macula densa cells. Am J Physiol Renal Physiol. 2003 Aug; 285(2):F275-80. PMID: 12709394.
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    46. Hwang EF, Williams I, Kovacs G, Peti-Peterdi J, Siroky B, Rice WC, Bates E, Schwiebert EM, Unlap MT, Bell PD. Impaired ability of the Na+/Ca2+ exchanger from the Dahl/Rapp salt-sensitive rat to regulate cytosolic calcium. Am J Physiol Renal Physiol. 2003 May; 284(5):F1023-31. PMID: 12527551.
      View in: PubMed
    47. Bell PD, Lapointe JY, Peti-Peterdi J. Macula densa cell signaling. Annu Rev Physiol. 2003; 65:481-500. PMID: 12524458.
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    48. Unlap T, Hwang E, Kovacs G, Peti-Peterdi J, Siroky B, Williams I, Bell PD. Dysregulation of [Ca2+](i) in OK-PTH cells expressing a mesangial cell Na+/Ca2+ exchanger isoform from Dahl/Rapp salt-sensitive rats. Ann N Y Acad Sci. 2002 Nov; 976:338-41. PMID: 12502577.
      View in: PubMed
    49. Unlap T, Hwang EH, Siroky BJ, Peti-Peterdi J, Kovacs G, Williams I, Bell PD. Enhanced susceptibility of a Na+/Ca2+ exchanger isoform from mesangial cells of salt-sensitive Dahl/Rapp rats to oxidative stress inactivation. Ann N Y Acad Sci. 2002 Nov; 976:342-4. PMID: 12502578.
      View in: PubMed
    50. Peti-Peterdi J, Morishima S, Bell PD, Okada Y. Two-photon excitation fluorescence imaging of the living juxtaglomerular apparatus. Am J Physiol Renal Physiol. 2002 Jul; 283(1):F197-201. PMID: 12060602.
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    51. Peti-Peterdi J, Warnock DG, Bell PD. Angiotensin II directly stimulates ENaC activity in the cortical collecting duct via AT(1) receptors. J Am Soc Nephrol. 2002 May; 13(5):1131-5. PMID: 11960999.
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    52. Liu R, Bell PD, Peti-Peterdi J, Kovacs G, Johansson A, Persson AE. Purinergic receptor signaling at the basolateral membrane of macula densa cells. J Am Soc Nephrol. 2002 May; 13(5):1145-51. PMID: 11961001.
      View in: PubMed
    53. Schwiebert EM, Wallace DP, Braunstein GM, King SR, Peti-Peterdi J, Hanaoka K, Guggino WB, Guay-Woodford LM, Bell PD, Sullivan LP, Grantham JJ, Taylor AL. Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F763-75. PMID: 11880338.
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    54. Kovács G, Peti-Peterdi J, Rosivall L, Bell PD. Angiotensin II directly stimulates macula densa Na-2Cl-K cotransport via apical AT(1) receptors. Am J Physiol Renal Physiol. 2002 Feb; 282(2):F301-6. PMID: 11788444.
      View in: PubMed
    55. Peti-Peterdi J, Bebok Z, Lapointe JY, Bell PD. Novel regulation of cell [Na(+)] in macula densa cells: apical Na(+) recycling by H-K-ATPase. Am J Physiol Renal Physiol. 2002 Feb; 282(2):F324-9. PMID: 11788447.
      View in: PubMed
    56. Unlap MT, Peti-Peterdi J, Bell PD. Cloning of mesangial cell Na(+)/Ca(2+) exchangers from Dahl/Rapp salt-sensitive/resistant rats. Am J Physiol Renal Physiol. 2000 Jul; 279(1):F177-84. PMID: 10894800.
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    57. Peti-Peterdi J, Chambrey R, Bebok Z, Biemesderfer D, St John PL, Abrahamson DR, Warnock DG, Bell PD. Macula densa Na(+)/H(+) exchange activities mediated by apical NHE2 and basolateral NHE4 isoforms. Am J Physiol Renal Physiol. 2000 Mar; 278(3):F452-63. PMID: 10710550.
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    58. Peti-Peterdi J, Bell PD. Cytosolic [Ca2+] signaling pathway in macula densa cells. Am J Physiol. 1999 09; 277(3):F472-6. PMID: 10484531.
      View in: PubMed
    59. Bell PD, Peti-Peterdi J. Angiotensin II stimulates macula densa basolateral sodium/hydrogen exchange via type 1 angiotensin II receptors. J Am Soc Nephrol. 1999 Jan; 10 Suppl 11:S225-9. PMID: 9892168.
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    60. Navar LG, Bell PD, Burke TJ. Role of a macula densa feedback mechanism as a mediator of renal autoregulation. Kidney Int Suppl. 1982 Aug; 12:S157-64. PMID: 6957671.
      View in: PubMed
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