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Narendra R Vyavahare

TitleEndowed Chair
InstitutionClemson University
DepartmentDepartment of Bioengineering
Address301 Rhodes Hall
Clemson, South Carolina 29634
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Karamched SR, Nosoudi N, Moreland HE, Chowdhury A, Vyavahare NR. Site-specific chelation therapy with EDTA-loaded albumin nanoparticles reverses arterial calcification in a rat model of chronic kidney disease. Sci Rep. 2019 Feb 22; 9(1):2629. PMID: 30796300.
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    2. Parasaram V, Nosoudi N, Chowdhury A, Vyavahare N. Pentagalloyl glucose increases elastin deposition, decreases reactive oxygen species and matrix metalloproteinase activity in pulmonary fibroblasts under inflammatory conditions. Biochem Biophys Res Commun. 2018 04 30; 499(1):24-29. PMID: 29550472.
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    3. Tam H, Zhang W, Infante D, Parchment N, Sacks M, Vyavahare N. Fixation of Bovine Pericardium-Based Tissue Biomaterial with Irreversible Chemistry Improves Biochemical and Biomechanical Properties. J Cardiovasc Transl Res. 2017 Apr; 10(2):194-205. PMID: 28213846.
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    4. Nosoudi N, Chowdhury A, Siclari S, Parasaram V, Karamched S, Vyavahare N. Systemic Delivery of Nanoparticles Loaded with Pentagalloyl Glucose Protects Elastic Lamina and Prevents Abdominal Aortic Aneurysm in Rats. J Cardiovasc Transl Res. 2016 12; 9(5-6):445-455. PMID: 27542007.
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    5. Nosoudi N, Chowdhury A, Siclari S, Karamched S, Parasaram V, Parrish J, Gerard P, Vyavahare N. Reversal of Vascular Calcification and Aneurysms in a Rat Model Using Dual Targeted Therapy with EDTA- and PGG-Loaded Nanoparticles. Theranostics. 2016; 6(11):1975-1987. PMID: 27698934.
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    6. Parasaram V, Nosoudi N, LeClair RJ, Binks A, Vyavahare N. Targeted drug delivery to emphysematous lungs: Inhibition of MMPs by doxycycline loaded nanoparticles. Pulm Pharmacol Ther. 2016 08; 39:64-73. PMID: 27354173.
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    7. Nosoudi N, Nahar-Gohad P, Sinha A, Chowdhury A, Gerard P, Carsten CG, Gray BH, Vyavahare NR. Prevention of abdominal aortic aneurysm progression by targeted inhibition of matrix metalloproteinase activity with batimastat-loaded nanoparticles. Circ Res. 2015 Nov 06; 117(11):e80-9. PMID: 26443597.
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    8. Tam H, Zhang W, Feaver KR, Parchment N, Sacks MS, Vyavahare N. A novel crosslinking method for improved tear resistance and biocompatibility of tissue based biomaterials. Biomaterials. 2015 Oct; 66:83-91. PMID: 26196535.
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    9. Simmers P, Gishto A, Vyavahare N, Kothapalli CR. Nitric oxide stimulates matrix synthesis and deposition by adult human aortic smooth muscle cells within three-dimensional cocultures. Tissue Eng Part A. 2015 Apr; 21(7-8):1455-70. PMID: 25597545.
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    10. Nahar-Gohad P, Gohad N, Tsai CC, Bordia R, Vyavahare N. Rat aortic smooth muscle cells cultured on hydroxyapatite differentiate into osteoblast-like cells via BMP-2-SMAD-5 pathway. Calcif Tissue Int. 2015 Apr; 96(4):359-69. PMID: 25725805.
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    11. Lei Y, Nosoudi N, Vyavahare N. Targeted chelation therapy with EDTA-loaded albumin nanoparticles regresses arterial calcification without causing systemic side effects. J Control Release. 2014 Dec 28; 196:79-86. PMID: 25285609.
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    12. Sinha A, Shaporev A, Nosoudi N, Lei Y, Vertegel A, Lessner S, Vyavahare N. Nanoparticle targeting to diseased vasculature for imaging and therapy. Nanomedicine. 2014 Jul; 10(5):1003-12. PMID: 24566276.
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    13. Lei Y, Sinha A, Nosoudi N, Grover A, Vyavahare N. Hydroxyapatite and calcified elastin induce osteoblast-like differentiation in rat aortic smooth muscle cells. Exp Cell Res. 2014 Apr 15; 323(1):198-208. PMID: 24447384.
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    14. Sinha A, Nosoudi N, Vyavahare N. Elasto-regenerative properties of polyphenols. Biochem Biophys Res Commun. 2014 Feb 07; 444(2):205-11. PMID: 24440697.
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    15. Tripi DR, Vyavahare NR. Neomycin and pentagalloyl glucose enhanced cross-linking for elastin and glycosaminoglycans preservation in bioprosthetic heart valves. J Biomater Appl. 2014 Jan; 28(5):757-66. PMID: 24371208.
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    16. Lei Y, Grover A, Sinha A, Vyavahare N. Efficacy of reversal of aortic calcification by chelating agents. Calcif Tissue Int. 2013 Nov; 93(5):426-35. PMID: 23963635.
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    17. Sinha A, Vyavahare NR. High-glucose levels and elastin degradation products accelerate osteogenesis in vascular smooth muscle cells. Diab Vasc Dis Res. 2013 Sep; 10(5):410-9. PMID: 23754846.
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    18. Eckert CE, Fan R, Mikulis B, Barron M, Carruthers CA, Friebe VM, Vyavahare NR, Sacks MS. On the biomechanical role of glycosaminoglycans in the aortic heart valve leaflet. Acta Biomater. 2013 Jan; 9(1):4653-60. PMID: 23036945.
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    19. Leong J, Munnelly A, Liberio B, Cochrane L, Vyavahare N. Neomycin and carbodiimide crosslinking as an alternative to glutaraldehyde for enhanced durability of bioprosthetic heart valves. J Biomater Appl. 2013 May; 27(8):948-60. PMID: 22207605.
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    20. Munnelly AE, Cochrane L, Leong J, Vyavahare NR. Porcine vena cava as an alternative to bovine pericardium in bioprosthetic percutaneous heart valves. Biomaterials. 2012 Jan; 33(1):1-8. PMID: 21993239.
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    21. Friebe VM, Mikulis B, Kole S, Ruffing CS, Sacks MS, Vyavahare NR. Neomycin enhances extracellular matrix stability of glutaraldehyde crosslinked bioprosthetic heart valves. J Biomed Mater Res B Appl Biomater. 2011 Nov; 99(2):217-29. PMID: 21714085.
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    22. Raghavan D, Shah SR, Vyavahare NR. Neomycin fixation followed by ethanol pretreatment leads to reduced buckling and inhibition of calcification in bioprosthetic valves. J Biomed Mater Res B Appl Biomater. 2010 Jan; 92(1):168-77. PMID: 19810110.
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    23. Cho E, Kutty JK, Datar K, Lee JS, Vyavahare NR, Webb K. A novel synthetic route for the preparation of hydrolytically degradable synthetic hydrogels. J Biomed Mater Res A. 2009 Sep 15; 90(4):1073-82. PMID: 18671270.
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    24. Kurane A, Vyavahare N. In vivo vascular tissue engineering: influence of cytokine and implant location on tissue specific cellular recruitment. J Tissue Eng Regen Med. 2009 Jun; 3(4):280-9. PMID: 19283727.
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    25. Raghavan D, Starcher BC, Vyavahare NR. Neomycin binding preserves extracellular matrix in bioprosthetic heart valves during in vitro cyclic fatigue and storage. Acta Biomater. 2009 May; 5(4):983-92. PMID: 19091637.
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    26. Zhang C, Wen X, Vyavahare NR, Boland T. Synthesis and characterization of biodegradable elastomeric polyurethane scaffolds fabricated by the inkjet technique. Biomaterials. 2008 Oct; 29(28):3781-91. PMID: 18602156.
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    27. Shah SR, Vyavahare NR. The effect of glycosaminoglycan stabilization on tissue buckling in bioprosthetic heart valves. Biomaterials. 2008 Apr; 29(11):1645-53. PMID: 18199477.
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    28. Kutty JK, Cho E, Soo Lee J, Vyavahare NR, Webb K. The effect of hyaluronic acid incorporation on fibroblast spreading and proliferation within PEG-diacrylate based semi-interpenetrating networks. Biomaterials. 2007 Nov; 28(33):4928-38. PMID: 17720239.
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    29. Simionescu A, Simionescu DT, Vyavahare NR. Osteogenic responses in fibroblasts activated by elastin degradation products and transforming growth factor-beta1: role of myofibroblasts in vascular calcification. Am J Pathol. 2007 Jul; 171(1):116-23. PMID: 17591959.
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    30. Isenburg JC, Simionescu DT, Starcher BC, Vyavahare NR. Elastin stabilization for treatment of abdominal aortic aneurysms. Circulation. 2007 Apr 03; 115(13):1729-37. PMID: 17372168.
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    31. Raghavan D, Simionescu DT, Vyavahare NR. Neomycin prevents enzyme-mediated glycosaminoglycan degradation in bioprosthetic heart valves. Biomaterials. 2007 Jun; 28(18):2861-8. PMID: 17353047.
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    32. Kurane A, Simionescu DT, Vyavahare NR. In vivo cellular repopulation of tubular elastin scaffolds mediated by basic fibroblast growth factor. Biomaterials. 2007 Jun; 28(18):2830-8. PMID: 17368531.
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    33. Sellaro TL, Hildebrand D, Lu Q, Vyavahare N, Scott M, Sacks MS. Effects of collagen fiber orientation on the response of biologically derived soft tissue biomaterials to cyclic loading. J Biomed Mater Res A. 2007 Jan; 80(1):194-205. PMID: 17041913.
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    34. Simpson CL, Lindley S, Eisenberg C, Basalyga DM, Starcher BC, Simionescu DT, Vyavahare NR. Toward cell therapy for vascular calcification: osteoclast-mediated demineralization of calcified elastin. Cardiovasc Pathol. 2007 Jan-Feb; 16(1):29-37. PMID: 17218212.
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    35. Mercuri JJ, Lovekamp JJ, Simionescu DT, Vyavahare NR. Glycosaminoglycan-targeted fixation for improved bioprosthetic heart valve stabilization. Biomaterials. 2007 Jan; 28(3):496-503. PMID: 17030363.
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    36. Isenburg JC, Karamchandani NV, Simionescu DT, Vyavahare NR. Structural requirements for stabilization of vascular elastin by polyphenolic tannins. Biomaterials. 2006 Jul; 27(19):3645-51. PMID: 16527345.
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    37. Lee JS, Basalyga DM, Simionescu A, Isenburg JC, Simionescu DT, Vyavahare NR. Elastin calcification in the rat subdermal model is accompanied by up-regulation of degradative and osteogenic cellular responses. Am J Pathol. 2006 Feb; 168(2):490-8. PMID: 16436663.
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    38. Lovekamp JJ, Simionescu DT, Mercuri JJ, Zubiate B, Sacks MS, Vyavahare NR. Stability and function of glycosaminoglycans in porcine bioprosthetic heart valves. Biomaterials. 2006 Mar; 27(8):1507-18. PMID: 16144707.
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    39. Simionescu A, Philips K, Vyavahare N. Elastin-derived peptides and TGF-beta1 induce osteogenic responses in smooth muscle cells. Biochem Biophys Res Commun. 2005 Aug 26; 334(2):524-32. PMID: 16005428.
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    40. Lu Q, Simionescu A, Vyavahare N. Novel capillary channel fiber scaffolds for guided tissue engineering. Acta Biomater. 2005 Nov; 1(6):607-14. PMID: 16701841.
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    41. Simionescu DT, Lu Q, Song Y, Lee JS, Rosenbalm TN, Kelley C, Vyavahare NR. Biocompatibility and remodeling potential of pure arterial elastin and collagen scaffolds. Biomaterials. 2006 Feb; 27(5):702-13. PMID: 16048731.
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    42. Isenburg JC, Simionescu DT, Vyavahare NR. Tannic acid treatment enhances biostability and reduces calcification of glutaraldehyde fixed aortic wall. Biomaterials. 2005 Apr; 26(11):1237-45. PMID: 15475053.
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    43. Connolly JM, Alferiev I, Clark-Gruel JN, Eidelman N, Sacks M, Palmatory E, Kronsteiner A, Defelice S, Xu J, Ohri R, Narula N, Vyavahare N, Levy RJ. Triglycidylamine crosslinking of porcine aortic valve cusps or bovine pericardium results in improved biocompatibility, biomechanics, and calcification resistance: chemical and biological mechanisms. Am J Pathol. 2005 Jan; 166(1):1-13. PMID: 15631995.
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    44. Basalyga DM, Simionescu DT, Xiong W, Baxter BT, Starcher BC, Vyavahare NR. Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinases. Circulation. 2004 Nov 30; 110(22):3480-7. PMID: 15545515.
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    45. Lu Q, Ganesan K, Simionescu DT, Vyavahare NR. Novel porous aortic elastin and collagen scaffolds for tissue engineering. Biomaterials. 2004 Oct; 25(22):5227-37. PMID: 15110474.
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    46. Isenburg JC, Simionescu DT, Vyavahare NR. Elastin stabilization in cardiovascular implants: improved resistance to enzymatic degradation by treatment with tannic acid. Biomaterials. 2004 Jul; 25(16):3293-302. PMID: 14980424.
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    47. Sun W, Sacks M, Fulchiero G, Lovekamp J, Vyavahare N, Scott M. Response of heterograft heart valve biomaterials to moderate cyclic loading. J Biomed Mater Res A. 2004 Jun 15; 69(4):658-69. PMID: 15162408.
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    48. Bailey M, Pillarisetti S, Jones P, Xiao H, Simionescu D, Vyavahare N. Involvement of matrix metalloproteinases and tenascin-C in elastin calcification. Cardiovasc Pathol. 2004 May-Jun; 13(3):146-55. PMID: 15081471.
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    49. Xu T, Petridou S, Lee EH, Roth EA, Vyavahare NR, Hickman JJ, Boland T. Construction of high-density bacterial colony arrays and patterns by the ink-jet method. Biotechnol Bioeng. 2004 Jan 05; 85(1):29-33. PMID: 14705009.
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    50. Simionescu DT, Lovekamp JJ, Vyavahare NR. Extracellular matrix degrading enzymes are active in porcine stentless aortic bioprosthetic heart valves. J Biomed Mater Res A. 2003 Sep 15; 66(4):755-63. PMID: 12926026.
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    51. Bailey MT, Pillarisetti S, Xiao H, Vyavahare NR. Role of elastin in pathologic calcification of xenograft heart valves. J Biomed Mater Res A. 2003 Jul 01; 66(1):93-102. PMID: 12833435.
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    52. Levy RJ, Vyavahare N, Ogle M, Ashworth P, Bianco R, Schoen FJ. Inhibition of cusp and aortic wall calcification in ethanol- and aluminum-treated bioprosthetic heart valves in sheep: background, mechanisms, and synergism. J Heart Valve Dis. 2003 Mar; 12(2):209-16; discussion 216. PMID: 12701794.
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    53. Simionescu DT, Lovekamp JJ, Vyavahare NR. Glycosaminoglycan-degrading enzymes in porcine aortic heart valves: implications for bioprosthetic heart valve degeneration. J Heart Valve Dis. 2003 Mar; 12(2):217-25. PMID: 12701795.
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    54. Simionescu DT, Lovekamp JJ, Vyavahare NR. Degeneration of bioprosthetic heart valve cusp and wall tissues is initiated during tissue preparation: an ultrastructural study. J Heart Valve Dis. 2003 Mar; 12(2):226-34. PMID: 12701796.
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    55. Bailey M, Xiao H, Ogle M, Vyavahare N. Aluminum chloride pretreatment of elastin inhibits elastolysis by matrix metalloproteinases and leads to inhibition of elastin-oriented calcification. Am J Pathol. 2001 Dec; 159(6):1981-6. PMID: 11733347.
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    56. Alferiev I, Vyavahare N, Song C, Connolly J, Hinson JT, Lu Z, Tallapragada S, Bianco R, Levy R. Bisphosphonate derivatized polyurethanes resist calcification. Biomaterials. 2001 Oct; 22(19):2683-93. PMID: 11519788.
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    57. Lovekamp J, Vyavahare N. Periodate-mediated glycosaminoglycan stabilization in bioprosthetic heart valves. J Biomed Mater Res. 2001 Sep 15; 56(4):478-86. PMID: 11400125.
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    58. Levy RJ, Song C, Tallapragada S, DeFelice S, Hinson JT, Vyavahare N, Connolly J, Ryan K, Li Q. Localized adenovirus gene delivery using antiviral IgG complexation. Gene Ther. 2001 May; 8(9):659-67. PMID: 11406760.
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    59. Vyavahare N, Jones PL, Tallapragada S, Levy RJ. Inhibition of matrix metalloproteinase activity attenuates tenascin-C production and calcification of implanted purified elastin in rats. Am J Pathol. 2000 Sep; 157(3):885-93. PMID: 10980128.
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    60. Vyavahare NR, Jones PL, Hirsch D, Schoen FJ, Levy RJ. Prevention of glutaraldehyde-fixed bioprosthetic heart valve calcification by alcohol pretreatment: further mechanistic studies. J Heart Valve Dis. 2000 Jul; 9(4):561-6. PMID: 10947050.
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    61. Vyavahare N, Ogle M, Schoen FJ, Levy RJ. Elastin calcification and its prevention with aluminum chloride pretreatment. Am J Pathol. 1999 Sep; 155(3):973-82. PMID: 10487855.
      View in: PubMed
    62. Vyavahare N, Ogle M, Schoen FJ, Zand R, Gloeckner DC, Sacks M, Levy RJ. Mechanisms of bioprosthetic heart valve failure: fatigue causes collagen denaturation and glycosaminoglycan loss. J Biomed Mater Res. 1999 Jul; 46(1):44-50. PMID: 10357134.
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    63. Mohler ER, Chawla MK, Chang AW, Vyavahare N, Levy RJ, Graham L, Gannon FH. Identification and characterization of calcifying valve cells from human and canine aortic valves. J Heart Valve Dis. 1999 May; 8(3):254-60. PMID: 10399657.
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    64. Lee CH, Vyavahare N, Zand R, Kruth H, Schoen FJ, Bianco R, Levy RJ. Inhibition of aortic wall calcification in bioprosthetic heart valves by ethanol pretreatment: biochemical and biophysical mechanisms. J Biomed Mater Res. 1998 Oct; 42(1):30-7. PMID: 9740004.
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    65. Vyavahare NR, Hirsch D, Lerner E, Baskin JZ, Zand R, Schoen FJ, Levy RJ. Prevention of calcification of glutaraldehyde-crosslinked porcine aortic cusps by ethanol preincubation: mechanistic studies of protein structure and water-biomaterial relationships. J Biomed Mater Res. 1998 Jun 15; 40(4):577-85. PMID: 9599034.
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    66. Vyavahare NR, Chen W, Joshi RR, Lee CH, Hirsch D, Levy J, Schoen FJ, Levy RJ. Current Progress in Anticalcif ication for Bioprosthetic and Polymeric Heart Valves. Cardiovasc Pathol. 1997 Jul; 6(4):219-29. PMID: 25991539.
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    67. Vyavahare N, Hirsch D, Lerner E, Baskin JZ, Schoen FJ, Bianco R, Kruth HS, Zand R, Levy RJ. Prevention of bioprosthetic heart valve calcification by ethanol preincubation. Efficacy and mechanisms. Circulation. 1997 Jan 21; 95(2):479-88. PMID: 9008467.
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