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Narayan R. Bhat

Title
InstitutionMedical University of South Carolina
DepartmentNeuroscience
AddressP.O. Box MSC 510
CRI 407
Children's Research Inst. - 173 Ashley Ave.
Phone843-792-7593
Fax843-792-4423
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Watson AN, Berthiaume AA, Faino AV, McDowell KP, Bhat NR, Hartmann DA, Shih AY. Mild pericyte deficiency is associated with aberrant brain microvascular flow in aged PDGFRß+/- mice. J Cereb Blood Flow Metab. 2020 12; 40(12):2387-2400. PMID: 31987006.
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    2. Berthiaume AA, Hartmann DA, Majesky MW, Bhat NR, Shih AY. Pericyte Structural Remodeling in Cerebrovascular Health and Homeostasis. Front Aging Neurosci. 2018; 10:210. PMID: 30065645.
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    3. Berthiaume AA, Grant RI, McDowell KP, Underly RG, Hartmann DA, Levy M, Bhat NR, Shih AY. Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain. Cell Rep. 2018 01 02; 22(1):8-16. PMID: 29298435.
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    4. Grant RI, Hartmann DA, Underly RG, Berthiaume AA, Bhat NR, Shih AY. Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex. J Cereb Blood Flow Metab. 2019 03; 39(3):411-425. PMID: 28933255.
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    5. Podbielska M, Szulc ZM, Kurowska E, Hogan EL, Bielawski J, Bielawska A, Bhat NR. Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line. J Lipid Res. 2016 11; 57(11):2028-2039. PMID: 27623848.
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    6. Pelluru D, Konadhode RR, Bhat NR, Shiromani PJ. Optogenetic stimulation of astrocytes in the posterior hypothalamus increases sleep at night in C57BL/6J mice. Eur J Neurosci. 2016 05; 43(10):1298-306. PMID: 26369866.
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    7. Bhat NR. Vasculoprotection as a Convergent, Multi-Targeted Mechanism of Anti-AD Therapeutics and Interventions. J Alzheimers Dis. 2015; 46(3):581-91. PMID: 26402511.
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    8. Hirschhorn J, Mohanty S, Bhat NR. The role of tumor progression locus 2 protein kinase in glial inflammatory response. J Neurochem. 2014 Mar; 128(6):919-26. PMID: 24188160.
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    9. Wang R, Li JJ, Diao S, Kwak YD, Liu L, Zhi L, Büeler H, Bhat NR, Williams RW, Park EA, Liao FF. Metabolic stress modulates Alzheimer's ß-secretase gene transcription via SIRT1-PPAR?-PGC-1 in neurons. Cell Metab. 2013 May 07; 17(5):685-94. PMID: 23663737.
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    10. Bhat NR, Thirumangalakudi L. Increased tau phosphorylation and impaired brain insulin/IGF signaling in mice fed a high fat/high cholesterol diet. J Alzheimers Dis. 2013; 36(4):781-9. PMID: 23703152.
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    11. Li X, Liu X, Cui L, Brunson C, Zhao W, Bhat NR, Zhang N, Wen X. Engineering an in situ crosslinkable hydrogel for enhanced remyelination. FASEB J. 2013 Mar; 27(3):1127-36. PMID: 23239823.
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    12. Sambamurti K, Greig NH, Utsuki T, Barnwell EL, Sharma E, Mazell C, Bhat NR, Kindy MS, Lahiri DK, Pappolla MA. Targets for AD treatment: conflicting messages from ?-secretase inhibitors. J Neurochem. 2011 May; 117(3):359-74. PMID: 21320126.
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    13. Yu J, Gattoni-Celli M, Zhu H, Bhat NR, Sambamurti K, Gattoni-Celli S, Kindy MS. Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of AßPP transgenic mice. J Alzheimers Dis. 2011; 25(2):295-307. PMID: 21422528.
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    14. Granholm AC, Zaman V, Godbee J, Smith M, Ramadan R, Umphlet C, Randall P, Bhat NR, Rohrer B, Middaugh LD, Boger HA. Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice. Brain Pathol. 2011 May; 21(3):330-48. PMID: 20969653.
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    15. Bhat NR. Linking cardiometabolic disorders to sporadic Alzheimer's disease: a perspective on potential mechanisms and mediators. J Neurochem. 2010 Nov; 115(3):551-62. PMID: 20807313.
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    16. Temple G, Gerhard DS, Rasooly R, Feingold EA, Good PJ, Robinson C, Mandich A, Derge JG, Lewis J, Shoaf D, Collins FS, Jang W, Wagner L, Shenmen CM, Misquitta L, Schaefer CF, Buetow KH, Bonner TI, Yankie L, Ward M, Phan L, Astashyn A, Brown G, Farrell C, Hart J, Landrum M, Maidak BL, Murphy M, Murphy T, Rajput B, Riddick L, Webb D, Weber J, Wu W, Pruitt KD, Maglott D, Siepel A, Brejova B, Diekhans M, Harte R, Baertsch R, Kent J, Haussler D, Brent M, Langton L, Comstock CL, Stevens M, Wei C, van Baren MJ, Salehi-Ashtiani K, Murray RR, Ghamsari L, Mello E, Lin C, Pennacchio C, Schreiber K, Shapiro N, Marsh A, Pardes E, Moore T, Lebeau A, Muratet M, Simmons B, Kloske D, Sieja S, Hudson J, Sethupathy P, Brownstein M, Bhat N, Lazar J, Jacob H, Gruber CE, Smith MR, McPherson J, Garcia AM, Gunaratne PH, Wu J, Muzny D, Gibbs RA, Young AC, Bouffard GG, Blakesley RW, Mullikin J, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Hirst M, Zeng T, Tse K, Moksa M, Deng M, Ma K, Mah D, Pang J, Taylor G, Chuah E, Deng A, Fichter K, Go A, Lee S, Wang J, Griffith M, Morin R, Moore RA, Mayo M, Munro S, Wagner S, Jones SJ, Holt RA, Marra MA, Lu S, Yang S, Hartigan J, Graf M, Wagner R, Letovksy S, Pulido JC, Robison K, Esposito D, Hartley J, Wall VE, Hopkins RF, Ohara O, Wiemann S. The completion of the Mammalian Gene Collection (MGC). Genome Res. 2009 Dec; 19(12):2324-33. PMID: 19767417.
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    17. Thirumangalakudi L, Prakasam A, Zhang R, Bimonte-Nelson H, Sambamurti K, Kindy MS, Bhat NR. High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J Neurochem. 2008 Jul; 106(1):475-85. PMID: 18410513.
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    18. Dasgupta S, Bhat NR, Spicer SS, Hogan EL, Furuya S, Hirabayashi Y. Cell-specific expression of neutral glycosphingolipids in vertebrate brain: immunochemical localization of 3-O-acetyl-sphingosine-series glycolipid(s) in myelin and oligodendrocytes. J Neurosci Res. 2007 Oct; 85(13):2856-62. PMID: 17638300.
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    19. Guo G, Bhat NR. p38alpha MAP kinase mediates hypoxia-induced motor neuron cell death: a potential target of minocycline's neuroprotective action. Neurochem Res. 2007 Dec; 32(12):2160-6. PMID: 17594516.
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    20. Bhat NR, Zhang P, Mohanty SB. p38 MAP kinase regulation of oligodendrocyte differentiation with CREB as a potential target. Neurochem Res. 2007 Feb; 32(2):293-302. PMID: 17235686.
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    21. Alderson NL, Maldonado EN, Kern MJ, Bhat NR, Hama H. FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain. J Lipid Res. 2006 Dec; 47(12):2772-80. PMID: 16998236.
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    22. Quintero EM, Willis L, Singleton R, Harris N, Huang P, Bhat N, Granholm AC. Behavioral and morphological effects of minocycline in the 6-hydroxydopamine rat model of Parkinson's disease. Brain Res. 2006 Jun 06; 1093(1):198-207. PMID: 16712819.
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    23. Pawate S, Bhat NR. C-Jun N-terminal kinase (JNK) regulation of iNOS expression in glial cells: predominant role of JNK1 isoform. Antioxid Redox Signal. 2006 May-Jun; 8(5-6):903-9. PMID: 16771680.
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    24. Guo G, Bhat NR. Hypoxia/reoxygenation differentially modulates NF-kappaB activation and iNOS expression in astrocytes and microglia. Antioxid Redox Signal. 2006 May-Jun; 8(5-6):911-8. PMID: 16771681.
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    25. Bhat NR, Feinstein DL. NO and glial cell biology. Antioxid Redox Signal. 2006 May-Jun; 8(5-6):869-72. PMID: 16771676.
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    26. Shen Q, Zhang R, Bhat NR. MAP kinase regulation of IP10/CXCL10 chemokine gene expression in microglial cells. Brain Res. 2006 May 01; 1086(1):9-16. PMID: 16635481.
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    27. Samuvel DJ, Jayanthi LD, Bhat NR, Ramamoorthy S. A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression. J Neurosci. 2005 Jan 05; 25(1):29-41. PMID: 15634764.
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    28. Pawate S, Shen Q, Fan F, Bhat NR. Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma. J Neurosci Res. 2004 Aug 15; 77(4):540-51. PMID: 15264224.
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    29. Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK, Mintzer JE. Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Curr Drug Targets. 2004 Aug; 5(6):517-28. PMID: 15270198.
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    30. Hunter CL, Quintero EM, Gilstrap L, Bhat NR, Granholm AC. Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning. Eur J Neurosci. 2004 Jun; 19(12):3305-16. PMID: 15217386.
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    31. Bhat NR, Shen Q, Fan F. TAK1-mediated induction of nitric oxide synthase gene expression in glial cells. J Neurochem. 2003 Oct; 87(1):238-47. PMID: 12969270.
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    32. Bhat NR, Fan F. Adenovirus infection induces microglial activation: involvement of mitogen-activated protein kinase pathways. Brain Res. 2002 Sep 06; 948(1-2):93-101. PMID: 12383959.
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    33. Bhat NR, Feinstein DL, Shen Q, Bhat AN. p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa B, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcription factor-2. J Biol Chem. 2002 Aug 16; 277(33):29584-92. PMID: 12048217.
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    34. Bhat NR, Sharma KK. Microglial activation by the small heat shock protein, alpha-crystallin. Neuroreport. 1999 Sep 09; 10(13):2869-73. PMID: 10511455.
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    35. Bhat NR, Zhang P, Bhat AN. Cytokine induction of inducible nitric oxide synthase in an oligodendrocyte cell line: role of p38 mitogen-activated protein kinase activation. J Neurochem. 1999 Feb; 72(2):472-8. PMID: 9930718.
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    36. Bhat NR, Zhang P. Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death. J Neurochem. 1999 Jan; 72(1):112-9. PMID: 9886061.
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    37. Andrews T, Zhang P, Bhat NR. TNFalpha potentiates IFNgamma-induced cell death in oligodendrocyte progenitors. J Neurosci Res. 1998 Dec 01; 54(5):574-83. PMID: 9843148.
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    38. Bhat NR, Zhang P, Lee JC, Hogan EL. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci. 1998 Mar 01; 18(5):1633-41. PMID: 9464988.
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    39. Zhang P, Hogan EL, Bhat NR. Activation of JNK/SAPK in primary glial cultures: II. Differential activation of kinase isoforms corresponds to their differential expression. Neurochem Res. 1998 Feb; 23(2):219-25. PMID: 9475517.
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    40. Sinha D, Bonner TI, Bhat NR, Matsuda LA. Expression of the CB1 cannabinoid receptor in macrophage-like cells from brain tissue: immunochemical characterization by fusion protein antibodies. J Neuroimmunol. 1998 Feb; 82(1):13-21. PMID: 9526841.
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    41. Dasgupta S, Everhart MB, Bhat NR, Hogan EL. Neutral monoglycosylceramides in rat brain: occurrence, molecular expression and developmental variation. Dev Neurosci. 1997; 19(2):152-61. PMID: 9097030.
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    42. Zhang P, Miller BS, Rosenzweig SA, Bhat NR. Activation of C-jun N-terminal kinase/stress-activated protein kinase in primary glial cultures. J Neurosci Res. 1996 Oct 01; 46(1):114-21. PMID: 8892112.
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    43. Bhat NR, Zhang P. Activation of mitogen-activated protein kinases in oligodendrocytes. J Neurochem. 1996 May; 66(5):1986-94. PMID: 8780027.
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    44. Bhat NR, Zhang P, Hogan EL. Thrombin activates mitogen-activated protein kinase in primary astrocyte cultures. J Cell Physiol. 1995 Nov; 165(2):417-24. PMID: 7593220.
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    45. Namboodiri MS, Zhang P, Bhat NR. Hyaluronectin binds to laminin and blocks laminin-dependent process formation by astrocytes. Neuroreport. 1995 Oct 23; 6(15):2037-40. PMID: 8580435.
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    46. Bhat NR. Signal transduction mechanisms in glial cells. Dev Neurosci. 1995; 17(5-6):267-84. PMID: 8829916.
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    47. Bhat NR, Zhang P, Bhat AN. The expression of myristoylated alanine-rich C-kinase substrate in oligodendrocytes is developmentally regulated. Dev Neurosci. 1995; 17(4):256-63. PMID: 8575345.
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    48. Bhat NR, Zhang P. Inhibitors of N-linked oligosaccharide processing glucosidases interfere with oligodendrocyte differentiation in culture. J Neurosci Res. 1994 Sep 01; 39(1):1-10. PMID: 7528816.
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    49. Hauser KF, Gurwell JA, Bhat NR. Endogenous opioid systems and the growth of oligodendrocyte progenitors: paradoxical increases in oligodendrogenesis as an indirect mechanism of opioid action. Glia. 1993 Oct; 9(2):157-62. PMID: 8244536.
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    50. Bhat NR, Hauser KF, Kindy MS. Cell proliferation and protooncogene induction in oligodendroglial progenitors. J Neurosci Res. 1992 Jul; 32(3):340-9. PMID: 1433384.
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    51. Kindy MS, Bhat AN, Bhat NR. Transient ischemia stimulates glial fibrillary acid protein and vimentin gene expression in the gerbil neocortex, striatum and hippocampus. Brain Res Mol Brain Res. 1992 Apr; 13(3):199-206. PMID: 1317493.
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    52. Bhat NR. Phosphorylation of MARCKS (80-kDa) protein, a major substrate for protein kinase C in oligodendroglial progenitors. J Neurosci Res. 1991 Oct; 30(2):447-54. PMID: 1798060.
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    53. Bhat NR, Frank DW, Wolf MJ, Waechter CJ. Developmental changes in enzymes involved in dolichyl phosphate metabolism in cultured embryonic rat brain cells. J Neurochem. 1991 Jan; 56(1):339-44. PMID: 1846175.
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    54. Bhat NR. Role of protein kinase C in glial cell proliferation. J Neurosci Res. 1989 Jan; 22(1):20-7. PMID: 2926838.
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    55. Bhat NR, Waechter CJ. Induction of N-glycosylation activity in cultured embryonic rat brain cells. J Neurochem. 1988 Feb; 50(2):375-81. PMID: 3335855.
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    56. Bhat NR. Effects of inhibitors of glycoprotein processing on oligodendroglial differentiation in primary cultures of embryonic rat brain cells. J Neurosci Res. 1988; 20(2):158-64. PMID: 2971819.
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    57. Bhat NR, Arimoto K, Warecka K, Brunngraber EG. Expression of alpha 2-glycoprotein by glial precursor cells: an immunocytochemical study with glial cultures. Brain Res. 1986 Sep; 394(1):31-6. PMID: 3530381.
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    58. Bhat NR, Brunngraber EG. Synthesis of sulfated glycoproteins by glial precursor cells. Neurochem Res. 1986 Aug; 11(8):1193-201. PMID: 3785540.
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    59. Volpe JJ, Goldberg RI, Bhat NR. Cholesterol biosynthesis and its regulation in dissociated cell cultures of fetal rat brain: developmental changes and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Neurochem. 1985 Aug; 45(2):536-43. PMID: 4009174.
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    60. Bhat NR, Brunngraber EG, Delpech B. Expression of hyaluronectin by C-6 glial cells at high density. J Neurochem. 1985 Jun; 44(6):1822-4. PMID: 2580953.
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    61. Bhat NR. Insulin dependent neurite outgrowth in cultured embryonic mouse brain cells. Brain Res. 1983 Dec; 313(2):315-8. PMID: 6365247.
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    62. Bhat NR, Shanker G, Pieringer RA. Cell proliferation in growing cultures of dissociated embryonic mouse brain: macromolecule and ornithine decarboxylase synthesis and regulation by hormones and drugs. J Neurosci Res. 1983; 10(2):221-30. PMID: 6195351.
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    63. Bhat NR, Shanker G, Pieringer RA. Investigations on myelination in vitro: regulation of 2,3'-cyclic nucleotide 3'-phosphohydrolase by thyroid hormone in cultures of dissociated brain cells from embryonic mice. J Neurochem. 1981 Sep; 37(3):695-701. PMID: 6268753.
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