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Michelle P. Hudspeth

TitleDirector, Division of Pediatric Hematology/Oncology
InstitutionMedical University of South Carolina
DepartmentPediatric Hematology/Oncology
AddressP.O. Box MSC 561
RN 520F
Roper Medical Office Bldg - 125 Doughty St., Charl
Phone843-792-2957
Fax843-792-8912
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    Collapse Overview 
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    Whether it’s on the floors of the hospital or Congress, Michelle Hudspeth, M.D., shows her passion for children.

    Voted as one of the 2013 Best Doctors, Hudspeth fights to find and get funding for the best possible treatments for children. Immune reconstitution after bone marrow transplant is one of her specialty areas. On average it takes a patient about six months to a year to have a normal immune system after transplant and the subsequent revaccination. In her research, Hudspeth looks for clues to determine the best timing for vaccination after transplant. Based on the quality of that research, Hudspeth was invited to speak at the 2013 American Society of Pediatric Hematology/Oncology combined with the Pediatric Blood and Marrow Transplant Consortium about revaccination strategies after allogeneic hematopoietic stem cell transplant.

    Hudspeth earned her medical degree from MUSC in 1999, completing her residency at Johns Hopkins Hospital, followed by a fellowship there in conjunction with the National Cancer Institute. Hudspeth was recruited back to her home state and MUSC in 2007 to lead the stem cell transplant program, the only one of its kind in the state. In just one year the number of pediatric transplants increased by 125 percent, with children not having to leave their home state to receive the best care, an important cause for her.

    Research shows that socioeconomic status is the biggest determinant of survival after transplant. Looking at the children of South Carolina based on zip code and income, MUSC takes care of children who are in the lowest quartile, which should predict a lower survival rate. But that’s not what’s happening in the Palmetto state. The outcomes are actually just as good as or better than national standards despite all these adverse factors.

    “I want people to know that our program here at MUSC is committed to delivering the best possible care for our children and so our unofficial slogan is: Make it happen. Give us the worst of odds and our goal is to turn that around.”

    Hudspeth, who testified about the drug shortage crisis at the Subcommittee on Health Care, District of Columbia, Census, and the National Archives November 2011 hearing, makes time for legislative advocacy work despite her busy schedule. Hudspeth provides blood or marrow transplants to approximately 30 patients a year, with her team treating patients from almost every county in the state.

    “Our goal everyday is to defy the odds. We are typically dealing with children who are in the worst of worst situations and who are facing a massive amount of obstacles. Our job every day is to get past that and make the impossible possible. There is nothing more gratifying than seeing kids walk through the door who never should’ve made it. And, that’s why our team is here. That’s what we focus on.”

    Collapse keywords
    Cancer/Leukemia, Children-s Health, Pediatrics, Cancer/Lymphoma, Cancer/Other, Drug Studies, Men-s Health, Pulmonary, Transplant, Adolescents, Cancer, Immune System, Infant, Women-s Health

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fabrizio V, Wahlquist A, Hill E, Williams E, Kramer C, Jaroscak J, Duong A, Garrett-Mayer E, Hudspeth M. The effect of bone marrow graft composition on pediatric bone marrow transplantation outcomes. Pediatr Transplant. 2018 12; 22(8):e13287. PMID: 30159974.
      View in: PubMed
    2. Jacobsohn DA, Loken MR, Fei M, Adams A, Brodersen LE, Logan BR, Ahn KW, Shaw BE, Kletzel M, Olszewski M, Khan S, Meshinchi S, Keating A, Harris A, Teira P, Duerst RE, Margossian SP, Martin PL, Petrovic A, Dvorak CC, Nemecek ER, Boyer MW, Chen AR, Davis JH, Shenoy S, Savasan S, Hudspeth MP, Adams RH, Lewis VA, Kheradpour A, Kasow KA, Gillio AP, Haight AE, Bhatia M, Bambach BJ, Haines HL, Quigg TC, Greiner RJ, Talano JM, Delgado DC, Cheerva A, Gowda M, Ahuja S, Ozkaynak M, Mitchell D, Schultz KR, Fry TJ, Loeb DM, Pulsipher MA. Outcomes of Measurable Residual Disease in Pediatric Acute Myeloid Leukemia before and after Hematopoietic Stem Cell Transplant: Validation of Difference from Normal Flow Cytometry with Chimerism Studies and Wilms Tumor 1 Gene Expression. Biol Blood Marrow Transplant. 2018 10; 24(10):2040-2046. PMID: 29933069.
      View in: PubMed
    3. Om A, Cathey SS, Gathings RM, Hudspeth M, Lee JA, Marzolf S, Wine Lee L. Phacomatosis Pigmentokeratotica: A Mosaic RASopathy with Malignant Potential. Pediatr Dermatol. 2017 May; 34(3):352-355. PMID: 28523882.
      View in: PubMed
    4. Lewis K, Butts R, Antonio Quiros J, Hudspeth M, Twombley K, Savage A, Self S, Burnette A, Sun S. Autoimmune enteropathy and hepatitis in pediatric heart transplant recipient. Pediatr Transplant. 2017 Mar; 21(2). PMID: 28097735.
      View in: PubMed
    5. Dumitriu A, Armeson K, Hudspeth M. Limited Role of Sinus CT in the Management of Febrile Pediatric HSCT Recipients. J Pediatr Hematol Oncol. 2016 08; 38(6):e186-8. PMID: 26535772.
      View in: PubMed
    6. Huenerberg K, Hudspeth M, Bergmann S, Pai S, Singh B, Duong A. Two cases of Vici syndrome associated with Idiopathic Thrombocytopenic Purpura (ITP) with a review of the literature. Am J Med Genet A. 2016 May; 170A(5):1343-6. PMID: 26854214.
      View in: PubMed
    7. Hudspeth M, Sun T, Parab N, Guo Z, Fezzaa K, Luo S, Chen W. Simultaneous X-ray diffraction and phase-contrast imaging for investigating material deformation mechanisms during high-rate loading. J Synchrotron Radiat. 2015 Jan; 22(1):49-58. PMID: 25537588.
      View in: PubMed
    8. Wagner JE, Eapen M, Carter S, Wang Y, Schultz KR, Wall DA, Bunin N, Delaney C, Haut P, Margolis D, Peres E, Verneris MR, Walters M, Horowitz MM, Kurtzberg J. One-unit versus two-unit cord-blood transplantation for hematologic cancers. N Engl J Med. 2014 Oct 30; 371(18):1685-94. PMID: 25354103.
      View in: PubMed
    9. Boles EE, Chiuzan C, Ragucci D, Hudspeth MP. Analysis of factors affecting immune recovery and initial response to tetanus after DTaP vaccination in pediatric allogeneic HSCT patients. Pediatr Transplant. 2014 Dec; 18(8):882-8. PMID: 25243374.
      View in: PubMed
    10. Hudspeth M, Turner A, Miller N, Lazarchick J. Pancytopenia after allogeneic bone marrow transplant due to copper deficiency. J Pediatr Hematol Oncol. 2014 May; 36(4):316-8. PMID: 23652881.
      View in: PubMed
    11. Hudspeth MP, Heath TS, Chiuzan C, Garrett-Mayer E, Nista E, Burton L, Ragucci D. Folinic acid administration after MTX GVHD prophylaxis in pediatric allo-SCT. Bone Marrow Transplant. 2013 Jan; 48(1):46-9. PMID: 22609886.
      View in: PubMed
    12. Post GR, Lewis JA, Hudspeth MP, Caplan MJ, Lazarchick J. Disseminated neuroendocrine carcinoma in a pediatric patient: a rare case and diagnostic challenge. J Pediatr Hematol Oncol. 2012 Apr; 34(3):200-3. PMID: 22134610.
      View in: PubMed
    13. Brown E, Hebra A, Jenrette J, Hudspeth M. Successful treatment of late, recurrent wilms tumor with high-dose chemotherapy and autologous stem cell rescue in third complete response. J Pediatr Hematol Oncol. 2010 Aug; 32(6):e241-3. PMID: 20628317.
      View in: PubMed
    14. Hudspeth MP, Hill TN, Lewis JA, Van Meter E, Ragucci D. Post-hematopoietic stem cell transplant immunization practices in the Pediatric Blood and Marrow Transplant Consortium. Pediatr Blood Cancer. 2010 Jul 01; 54(7):970-5. PMID: 20135703.
      View in: PubMed
    15. Hudspeth MP, Joseph S, Holden KR. A novel mutation in type II methemoglobinemia. J Child Neurol. 2010 Jan; 25(1):91-3. PMID: 19471045.
      View in: PubMed
    16. Angotti LB, Post GR, Robinson NS, Lewis JA, Hudspeth MP, Lazarchick J. Pancytopenia with myelodysplasia due to copper deficiency. Pediatr Blood Cancer. 2008 Nov; 51(5):693-5. PMID: 18623212.
      View in: PubMed
    17. Hudspeth MP, Raymond GV. Immunopathogenesis of adrenoleukodystrophy: current understanding. J Neuroimmunol. 2007 Jan; 182(1-2):5-12. PMID: 17125847.
      View in: PubMed
    18. Hudspeth MP, Holden KR, Crawford TO. The "slurp" test: bedside evaluation of bulbar muscle fatigue. Pediatrics. 2006 Aug; 118(2):e530-3. PMID: 16847079.
      View in: PubMed
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