Keywords
Last Name
Institution

Michael R. Zile

TitleEndowed Chair, Charles Ezra Daniel for Cardiology
InstitutionMedical University of South Carolina
DepartmentCardiology
AddressP.O. Box MSC 592
BM 323
Thurmond Gazes - 30 Courtenay Drive
Phone843-792-6866
Fax843-876-4809
vCardDownload vCard

    Collapse Overview 
    Collapse keywords
    Heart, Cardiovascular

    Collapse ORNG Applications 
    Collapse studies/trials

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Shen L, Rørth R, Cosmi D, Kristensen SL, Petrie MC, Cosmi F, Latini R, Køber L, Anand IS, Carson PE, Granger CB, Komajda M, McKelvie RS, Solomon SD, Staszewsky L, Swedberg K, Huynh T, Zile MR, Jhund PS, McMurray JJV. Insulin treatment and clinical outcomes in patients with diabetes and heart failure with preserved ejection fraction. Eur J Heart Fail. 2019 Jul 04. PMID: 31271255.
      View in: PubMed
    2. Litwin SE, Zile MR. Should We Test for Diastolic Dysfunction? How and How Often? JACC Cardiovasc Imaging. 2019 Jun 07. PMID: 31202743.
      View in: PubMed
    3. Houston BA, Tedford RJ, Baxley RL, Sykes B, Powers ER, Nielsen CD, Steinberg DH, Maran A, Fernandes VLC, Todoran T, Jones JA, Zile MR. Relation of Lymphangiogenic Factor Vascular Endothelial Growth Factor-D to Elevated Pulmonary Artery Wedge Pressure. Am J Cardiol. 2019 Jun 06. PMID: 31296367.
      View in: PubMed
    4. Balmforth C, Simpson J, Shen L, Jhund PS, Lefkowitz M, Rizkala AR, Rouleau JL, Shi V, Solomon SD, Swedberg K, Zile MR, Packer M, McMurray JJV. Outcomes and Effect of Treatment According to Etiology in HFrEF: An Analysis of PARADIGM-HF. JACC Heart Fail. 2019 Jun; 7(6):457-465. PMID: 31078482.
      View in: PubMed
    5. Arif E, Solanki AK, Srivastava P, Rahman B, Fitzgibbon WR, Deng P, Budisavljevic MN, Baicu CF, Zile MR, Megyesi J, Janech MG, Kwon SH, Collier J, Schnellmann RG, Nihalani D. Mitochondrial biogenesis induced by the ß2-adrenergic receptor agonist formoterol accelerates podocyte recovery from glomerular injury. Kidney Int. 2019 May 06. PMID: 31262488.
      View in: PubMed
    6. Lindenfeld J, Abraham WT, Maisel A, Zile M, Smart F, Costanzo MR, Mehra MR, Ducharme A, Sears SF, Desai AS, Paul S, Sood P, Johnson N, Ginn G, Adamson PB. Hemodynamic-GUIDEd management of Heart Failure (GUIDE-HF). Am Heart J. 2019 Aug; 214:18-27. PMID: 31150790.
      View in: PubMed
    7. Shen L, Jhund PS, Docherty KF, Petrie MC, Anand IS, Carson PE, Desai AS, Granger CB, Komajda M, McKelvie RS, Pfeffer MA, Solomon SD, Swedberg K, Zile MR, McMurray JJV. Prior Pacemaker Implantation and Clinical Outcomes in Patients With Heart Failure and Preserved Ejection Fraction. JACC Heart Fail. 2019 May; 7(5):418-427. PMID: 30981744.
      View in: PubMed
    8. Myhre PL, Vaduganathan M, Claggett B, Packer M, Desai AS, Rouleau JL, Zile MR, Swedberg K, Lefkowitz M, Shi V, McMurray JJV, Solomon SD. B-Type Natriuretic Peptide During Treatment With Sacubitril/Valsartan: The PARADIGM-HF Trial. J Am Coll Cardiol. 2019 Mar 26; 73(11):1264-1272. PMID: 30846338.
      View in: PubMed
    9. Kristensen SL, Mogensen UM, Jhund PS, Rørth R, Anand IS, Carson PE, Desai AS, Pitt B, Pfeffer MA, Solomon SD, Zile MR, Køber L, McMurray JJV. N-Terminal Pro-B-Type Natriuretic Peptide Levels for Risk Prediction in Patients With Heart Failure and Preserved Ejection Fraction According to Atrial Fibrillation Status. Circ Heart Fail. 2019 Mar; 12(3):e005766. PMID: 30871349.
      View in: PubMed
    10. Zile MR, O'Meara E, Claggett B, Prescott MF, Solomon SD, Swedberg K, Packer M, McMurray JJV, Shi V, Lefkowitz M, Rouleau J. Effects of Sacubitril/Valsartan on Biomarkers of Extracellular Matrix Regulation in Patients With HFrEF. J Am Coll Cardiol. 2019 Feb 26; 73(7):795-806. PMID: 30784673.
      View in: PubMed
    11. Vardeny O, Claggett B, Kachadourian J, Desai AS, Packer M, Rouleau J, Zile MR, Swedberg K, Lefkowitz M, Shi V, McMurray JJV, Solomon SD. Reduced loop diuretic use in patients taking sacubitril/valsartan compared with enalapril: the PARADIGM-HF trial. Eur J Heart Fail. 2019 03; 21(3):337-341. PMID: 30741494.
      View in: PubMed
    12. Dewan P, Rørth R, Jhund PS, Ferreira JP, Zannad F, Shen L, Køber L, Abraham WT, Desai AS, Dickstein K, Packer M, Rouleau JL, Solomon SD, Swedberg K, Zile MR, McMurray JJV. Income Inequality and Outcomes in Heart Failure: A Global Between-Country Analysis. JACC Heart Fail. 2019 Apr; 7(4):336-346. PMID: 30738981.
      View in: PubMed
    13. Dewan P, Rørth R, Jhund PS, Shen L, Raparelli V, Petrie MC, Abraham WT, Desai AS, Dickstein K, Køber L, Mogensen UM, Packer M, Rouleau JL, Solomon SD, Swedberg K, Zile MR, McMurray JJV. Differential Impact of Heart Failure With Reduced Ejection Fraction on Men and Women. J Am Coll Cardiol. 2019 Jan 08; 73(1):29-40. PMID: 30621948.
      View in: PubMed
    14. Akerman AW, Blanding WM, Stroud RE, Nadeau EK, Mukherjee R, Ruddy JM, Zile MR, Ikonomidis JS, Jones JA. Elevated Wall Tension Leads to Reduced miR-133a in the Thoracic Aorta by Exosome Release. J Am Heart Assoc. 2019 Jan 08; 8(1):e010332. PMID: 30572760.
      View in: PubMed
    15. Tromp J, MacDonald MR, Tay WT, Teng TK, Hung CL, Narasimhan C, Shimizu W, Ling LH, Ng TP, Yap J, McMurray JJV, Zile MR, Richards AM, Anand IS, Lam CSP. Heart Failure With Preserved Ejection Fraction in the Young. Circulation. 2018 Dec 11; 138(24):2763-2773. PMID: 30565987.
      View in: PubMed
    16. Dewan P, Jhund PS, Shen L, Petrie MC, Abraham WT, Atif Ali M, Chen CH, Desai AS, Dickstein K, Huang J, Kiatchoosakun S, Kim KS, Køber L, Lai WT, Liao Y, Mogensen UM, Oh BH, Packer M, Rouleau JL, Shi V, Sibulo AS, Solomon SD, Sritara P, Swedberg K, Tsutsui H, Zile MR, McMurray JJV. Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas. Eur J Heart Fail. 2019 May; 21(5):577-587. PMID: 30536678.
      View in: PubMed
    17. Rørth R, Jhund PS, Kristensen SL, Desai AS, Køber L, Rouleau JL, Solomon SD, Swedberg K, Zile MR, Packer M, McMurray JJV. The prognostic value of troponin T and N-terminal pro B-type natriuretic peptide, alone and in combination, in heart failure patients with and without diabetes. Eur J Heart Fail. 2019 01; 21(1):40-49. PMID: 30537261.
      View in: PubMed
    18. Srivastava PK, Claggett BL, Solomon SD, McMurray JJV, Packer M, Zile MR, Desai AS, Rouleau JL, Swedberg K, Fonarow GC. Estimated 5-Year Number Needed to Treat to Prevent Cardiovascular Death or Heart Failure Hospitalization With Angiotensin Receptor-Neprilysin Inhibition vs Standard Therapy for Patients With Heart Failure With Reduced Ejection Fraction: An Analysis of Data From the PARADIGM-HF Trial. JAMA Cardiol. 2018 Nov 28. PMID: 30484837.
      View in: PubMed
    19. Oatmen KE, Zile MR, Burnett JC, Spinale FG. Bioactive Signaling in Next-Generation Pharmacotherapies for Heart Failure: A Review. JAMA Cardiol. 2018 Nov 28. PMID: 30484834.
      View in: PubMed
    20. Dickinson MG, Allen LA, Albert NA, DiSalvo T, Ewald GA, Vest AR, Whellan DJ, Zile MR, Givertz MM. Remote Monitoring of Patients With Heart Failure: A White Paper From the Heart Failure Society of America Scientific Statements Committee. J Card Fail. 2018 Oct; 24(10):682-694. PMID: 30308242.
      View in: PubMed
    21. Ramires FJA, Martinez F, Gómez EA, Demacq C, Gimpelewicz CR, Rouleau JL, Solomon SD, Swedberg K, Zile MR, Packer M, McMurray JJV. Post hoc analyses of SHIFT and PARADIGM-HF highlight the importance of chronic Chagas' cardiomyopathy Comment on: "Safety profile and efficacy of ivabradine in heart failure due to Chagas heart disease: a post hoc analysis of the SHIFT trial" by Bocchi et al. ESC Heart Fail. 2018 12; 5(6):1069-1071. PMID: 30298996.
      View in: PubMed
    22. Januzzi JL, Packer M, Claggett B, Liu J, Shah AM, Zile MR, Pieske B, Voors A, Gandhi PU, Prescott MF, Shi V, Lefkowitz MP, McMurray JJV, Solomon SD. IGFBP7 (Insulin-Like Growth Factor-Binding Protein-7) and Neprilysin Inhibition in Patients With Heart Failure. Circ Heart Fail. 2018 Oct; 11(10):e005133. PMID: 30354399.
      View in: PubMed
    23. Bouabdallaoui N, Claggett B, Zile MR, McMurray JJV, O'Meara E, Packer M, Prescott MF, Swedberg K, Solomon SD, Rouleau JL. Growth differentiation factor-15 is not modified by sacubitril/valsartan and is an independent marker of risk in patients with heart failure and reduced ejection fraction: the PARADIGM-HF trial. Eur J Heart Fail. 2018 12; 20(12):1701-1709. PMID: 30204280.
      View in: PubMed
    24. Tromp J, Teng TH, Tay WT, Hung CL, Narasimhan C, Shimizu W, Park SW, Liew HB, Ngarmukos T, Reyes EB, Siswanto BB, Yu CM, Zhang S, Yap J, MacDonald M, Ling LH, Leineweber K, Richards AM, Zile MR, Anand IS, Lam CSP. Heart failure with preserved ejection fraction in Asia. Eur J Heart Fail. 2019 01; 21(1):23-36. PMID: 30113120.
      View in: PubMed
    25. Mack MJ, Abraham WT, Lindenfeld J, Bolling SF, Feldman TE, Grayburn PA, Kapadia SR, McCarthy PM, Lim DS, Udelson JE, Zile MR, Gammie JS, Gillinov AM, Glower DD, Heimansohn DA, Suri RM, Ellis JT, Shu Y, Kar S, Weissman NJ, Stone GW. Cardiovascular Outcomes Assessment of the MitraClip in Patients with Heart Failure and Secondary Mitral Regurgitation: Design and rationale of the COAPT trial. Am Heart J. 2018 11; 205:1-11. PMID: 30134187.
      View in: PubMed
    26. Lam PH, Gupta N, Dooley DJ, Singh S, Deedwania P, Zile MR, Bhatt DL, Morgan CJ, Pitt B, Fonarow GC, Ahmed A. Role of High-Dose Beta-Blockers in Patients with Heart Failure with Preserved Ejection Fraction and Elevated Heart Rate. Am J Med. 2018 Dec; 131(12):1473-1481. PMID: 30076815.
      View in: PubMed
    27. Zile MR, Abraham WT, Lindenfeld J, Weaver FA, Zannad F, Graves T, Rogers T, Galle EG. First granted example of novel FDA trial design under Expedited Access Pathway for premarket approval: BeAT-HF. Am Heart J. 2018 10; 204:139-150. PMID: 30118942.
      View in: PubMed
    28. Yeshwant SC, Zile MR, Lewis MR, Lewinter M, Meyer M. Safety and Feasibility of a Nocturnal Heart Rate Elevation-Exploration of a Novel Treatment Concept. J Card Fail. 2019 01; 25(1):67-71. PMID: 30026129.
      View in: PubMed
    29. Torres WM, Jacobs J, Doviak H, Barlow SC, Zile MR, Shazly T, Spinale FG. Regional and temporal changes in left ventricular strain and stiffness in a porcine model of myocardial infarction. Am J Physiol Heart Circ Physiol. 2018 Oct 01; 315(4):H958-H967. PMID: 30004234.
      View in: PubMed
    30. Solomon SD, Rizkala AR, Lefkowitz MP, Shi VC, Gong J, Anavekar N, Anker SD, Arango JL, Arenas JL, Atar D, Ben-Gal T, Boytsov SA, Chen CH, Chopra VK, Cleland J, Comin-Colet J, Duengen HD, Echeverría Correa LE, Filippatos G, Flammer AJ, Galinier M, Godoy A, Goncalvesova E, Janssens S, Katova T, Køber L, Lelonek M, Linssen G, Lund LH, O'Meara E, Merkely B, Milicic D, Oh BH, Perrone SV, Ranjith N, Saito Y, Saraiva JF, Shah S, Seferovic PM, Senni M, Sibulo AS, Sim D, Sweitzer NK, Taurio J, Vinereanu D, Vrtovec B, Widimský J, Yilmaz MB, Zhou J, Zweiker R, Anand IS, Ge J, Lam CSP, Maggioni AP, Martinez F, Packer M, Pfeffer MA, Pieske B, Redfield MM, Rouleau JL, Van Veldhuisen DJ, Zannad F, Zile MR, McMurray JJV. Baseline Characteristics of Patients With Heart Failure and Preserved Ejection Fraction in the PARAGON-HF Trial. Circ Heart Fail. 2018 07; 11(7):e004962. PMID: 29980595.
      View in: PubMed
    31. Chandra A, Lewis EF, Claggett BL, Desai AS, Packer M, Zile MR, Swedberg K, Rouleau JL, Shi VC, Lefkowitz MP, Katova T, McMurray JJV, Solomon SD. Effects of Sacubitril/Valsartan on Physical and Social Activity Limitations in Patients With Heart Failure: A Secondary Analysis of the PARADIGM-HF Trial. JAMA Cardiol. 2018 Jun 01; 3(6):498-505. PMID: 29617523.
      View in: PubMed
    32. Tromp J, Tay WT, Ouwerkerk W, Teng TK, Yap J, MacDonald MR, Leineweber K, McMurray JJV, Zile MR, Anand IS, Richards AM, Lam CSP. Correction: Multimorbidity in patients with heart failure from 11 Asian regions: A prospective cohort study using the ASIAN-HF registry. PLoS Med. 2018 05; 15(5):e1002583. PMID: 29799848.
      View in: PubMed
    33. O'Meara E, Prescott MF, Claggett B, Rouleau JL, Chiang LM, Solomon SD, Packer M, McMurray JJV, Zile MR. Independent Prognostic Value of Serum Soluble ST2 Measurements in Patients With Heart Failure and a Reduced Ejection Fraction in the PARADIGM-HF Trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure). Circ Heart Fail. 2018 05; 11(5):e004446. PMID: 29748349.
      View in: PubMed
    34. Halbach M, Abraham WT, Butter C, Ducharme A, Klug D, Little WC, Reuter H, Schafer JE, Senni M, Swarup V, Wachter R, Weaver FA, Wilks SJ, Zile MR, Müller-Ehmsen J. Baroreflex activation therapy for the treatment of heart failure with reduced ejection fraction in patients with and without coronary artery disease. Int J Cardiol. 2018 Sep 01; 266:187-192. PMID: 29705650.
      View in: PubMed
    35. Packer M, Claggett B, Lefkowitz MP, McMurray JJV, Rouleau JL, Solomon SD, Zile MR. Effect of neprilysin inhibition on renal function in patients with type 2 diabetes and chronic heart failure who are receiving target doses of inhibitors of the renin-angiotensin system: a secondary analysis of the PARADIGM-HF trial. Lancet Diabetes Endocrinol. 2018 07; 6(7):547-554. PMID: 29661699.
      View in: PubMed
    36. Damman K, Gori M, Claggett B, Jhund PS, Senni M, Lefkowitz MP, Prescott MF, Shi VC, Rouleau JL, Swedberg K, Zile MR, Packer M, Desai AS, Solomon SD, McMurray JJV. Renal Effects and Associated Outcomes During Angiotensin-Neprilysin Inhibition in Heart Failure. JACC Heart Fail. 2018 Jun; 6(6):489-498. PMID: 29655829.
      View in: PubMed
    37. Vardeny O, Claggett B, Kachadourian J, Pearson SM, Desai AS, Packer M, Rouleau J, Zile MR, Swedberg K, Lefkowitz M, Shi V, McMurray JJV, Solomon SD. Incidence, Predictors, and Outcomes Associated With Hypotensive Episodes Among Heart Failure Patients Receiving Sacubitril/Valsartan or Enalapril: The PARADIGM-HF Trial (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure). Circ Heart Fail. 2018 04; 11(4):e004745. PMID: 29643067.
      View in: PubMed
    38. Tromp J, Tay WT, Ouwerkerk W, Teng TK, Yap J, MacDonald MR, Leineweber K, McMurray JJV, Zile MR, Anand IS, Richards AMR, Lam CSP. Multimorbidity in patients with heart failure from 11 Asian regions: A prospective cohort study using the ASIAN-HF registry. PLoS Med. 2018 03; 15(3):e1002541. PMID: 29584721.
      View in: PubMed
    39. McDonald LT, Zile MR, Zhang Y, Van Laer AO, Baicu CF, Stroud RE, Jones JA, LaRue AC, Bradshaw AD. Increased macrophage-derived SPARC precedes collagen deposition in myocardial fibrosis. Am J Physiol Heart Circ Physiol. 2018 07 01; 315(1):H92-H100. PMID: 29522370.
      View in: PubMed
    40. Vaduganathan M, Claggett B, Packer M, McMurray JJV, Rouleau JL, Zile MR, Swedberg K, Solomon SD. Natriuretic Peptides as Biomarkers of Treatment Response in Clinical Trials of Heart Failure. JACC Heart Fail. 2018 Jul; 6(7):564-569. PMID: 29501807.
      View in: PubMed
    41. Mogensen UM, Gong J, Jhund PS, Shen L, Køber L, Desai AS, Lefkowitz MP, Packer M, Rouleau JL, Solomon SD, Claggett BL, Swedberg K, Zile MR, Mueller-Velten G, McMurray JJV. Effect of sacubitril/valsartan on recurrent events in the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF). Eur J Heart Fail. 2018 04; 20(4):760-768. PMID: 29431251.
      View in: PubMed
    42. Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M. Cardiac macrophages promote diastolic dysfunction. J Exp Med. 2018 02 05; 215(2):423-440. PMID: 29339450.
      View in: PubMed
    43. Mogensen UM, Jhund PS, Abraham WT, Desai AS, Dickstein K, Packer M, Rouleau JL, Solomon SD, Swedberg K, Zile MR, Køber L, McMurray JJV. Type of Atrial Fibrillation and Outcomes in Patients With Heart Failure and Reduced Ejection Fraction. J Am Coll Cardiol. 2017 Nov 14; 70(20):2490-2500. PMID: 29145948.
      View in: PubMed
    44. LeWinter MM, Taatjes D, Ashikaga T, Palmer B, Bishop N, VanBuren P, Bell S, Donaldson C, Meyer M, Margulies KB, Redfield M, Bull DA, Zile M. Abundance, localization, and functional correlates of the advanced glycation end-product carboxymethyl lysine in human myocardium. Physiol Rep. 2017 Nov; 5(20). PMID: 29066596.
      View in: PubMed
    45. Shen L, Ramires F, Martinez F, Bodanese LC, Echeverría LE, Gómez EA, Abraham WT, Dickstein K, Køber L, Packer M, Rouleau JL, Solomon SD, Swedberg K, Zile MR, Jhund PS, Gimpelewicz CR, McMurray JJV. Contemporary Characteristics and Outcomes in Chagasic Heart Failure Compared With Other Nonischemic and Ischemic Cardiomyopathy. Circ Heart Fail. 2017 Nov; 10(11). PMID: 29141857.
      View in: PubMed
    46. Fitzgibbon WR, Dang Y, Bunni MA, Baicu CF, Zile MR, Mullick AE, Saigusa T. Attenuation of accelerated renal cystogenesis in Pkd1 mice by renin-angiotensin system blockade. Am J Physiol Renal Physiol. 2018 02 01; 314(2):F210-F218. PMID: 29021226.
      View in: PubMed
    47. Lam PH, Dooley DJ, Deedwania P, Singh SN, Bhatt DL, Morgan CJ, Butler J, Mohammed SF, Wu WC, Panjrath G, Zile MR, White M, Arundel C, Love TE, Blackman MR, Allman RM, Aronow WS, Anker SD, Fonarow GC, Ahmed A. Heart Rate and Outcomes in Hospitalized Patients With Heart Failure With Preserved Ejection Fraction. J Am Coll Cardiol. 2017 Oct 10; 70(15):1861-1871. PMID: 28982499.
      View in: PubMed
    48. Kristensen SL, Jhund PS, Mogensen UM, Rørth R, Abraham WT, Desai A, Dickstein K, Rouleau JL, Zile MR, Swedberg K, Packer M, Solomon SD, Køber L, McMurray JJV. Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide Levels in Heart Failure Patients With and Without Atrial Fibrillation. Circ Heart Fail. 2017 Oct; 10(10). PMID: 29018174.
      View in: PubMed
    49. Fitzgibbons TP, Edwards YJK, Shaw P, Iskandar A, Ahmed M, Bote J, Shah T, Sinha S, Gerszten RE, Keaney JF, Zile MR, Aurigemma GP. Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy. Front Cardiovasc Med. 2017; 4:49. PMID: 28824923.
      View in: PubMed
    50. Lewis EF, Claggett BL, McMurray JJV, Packer M, Lefkowitz MP, Rouleau JL, Liu J, Shi VC, Zile MR, Desai AS, Solomon SD, Swedberg K. Health-Related Quality of Life Outcomes in PARADIGM-HF. Circ Heart Fail. 2017 Aug; 10(8). PMID: 28784687.
      View in: PubMed
    51. Shen L, Jhund PS, Petrie MC, Claggett BL, Barlera S, Cleland JGF, Dargie HJ, Granger CB, Kjekshus J, Køber L, Latini R, Maggioni AP, Packer M, Pitt B, Solomon SD, Swedberg K, Tavazzi L, Wikstrand J, Zannad F, Zile MR, McMurray JJV. Declining Risk of Sudden Death in Heart Failure. N Engl J Med. 2017 07 06; 377(1):41-51. PMID: 28679089.
      View in: PubMed
    52. Solomon SD, Rizkala AR, Gong J, Wang W, Anand IS, Ge J, Lam CSP, Maggioni AP, Martinez F, Packer M, Pfeffer MA, Pieske B, Redfield MM, Rouleau JL, Van Veldhuisen DJ, Zannad F, Zile MR, Desai AS, Shi VC, Lefkowitz MP, McMurray JJV. Angiotensin Receptor Neprilysin Inhibition in Heart Failure With Preserved Ejection Fraction: Rationale and Design of the PARAGON-HF Trial. JACC Heart Fail. 2017 07; 5(7):471-482. PMID: 28662936.
      View in: PubMed
    53. Minatoguchi S, Kawasaki M, Tanaka R, Yoshizane T, Ono K, Saeki M, Nagaya M, Sato H, Nishigaki K, Noda T, Zile MR, Minatoguchi S. Evaluation of systolic and diastolic properties of hypertensive heart failure using speckle-tracking echocardiography with high volume rates. Heart Vessels. 2017 Oct; 32(10):1202-1213. PMID: 28638961.
      View in: PubMed
    54. Taylor GJ, Lee DM, Baicu CF, Zile MR. Palliative Care for Advanced Heart Failure in a Department of Veterans Affairs Regional Hospice Program: Patient Selection, a Treatment Protocol, and Clinical Course. J Palliat Med. 2017 10; 20(10):1068-1073. PMID: 28530501.
      View in: PubMed
    55. Chow SL, Maisel AS, Anand I, Bozkurt B, de Boer RA, Felker GM, Fonarow GC, Greenberg B, Januzzi JL, Kiernan MS, Liu PP, Wang TJ, Yancy CW, Zile MR. Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure: A Scientific Statement From the American Heart Association. Circulation. 2017 May 30; 135(22):e1054-e1091. PMID: 28446515.
      View in: PubMed
    56. Böhm M, Young R, Jhund PS, Solomon SD, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Swedberg K, Zile MR, Packer M, McMurray JJV. Systolic blood pressure, cardiovascular outcomes and efficacy and safety of sacubitril/valsartan (LCZ696) in patients with chronic heart failure and reduced ejection fraction: results from PARADIGM-HF. Eur Heart J. 2017 04 14; 38(15):1132-1143. PMID: 28158398.
      View in: PubMed
    57. Seferovic JP, Claggett B, Seidelmann SB, Seely EW, Packer M, Zile MR, Rouleau JL, Swedberg K, Lefkowitz M, Shi VC, Desai AS, McMurray JJV, Solomon SD. Effect of sacubitril/valsartan versus enalapril on glycaemic control in patients with heart failure and diabetes: a post-hoc analysis from the PARADIGM-HF trial. Lancet Diabetes Endocrinol. 2017 05; 5(5):333-340. PMID: 28330649.
      View in: PubMed
    58. Mogensen UM, Køber L, Kristensen SL, Jhund PS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Swedberg K, Zile MR, Solomon SD, Packer M, McMurray JJV. The effects of sacubitril/valsartan on coronary outcomes in PARADIGM-HF. Am Heart J. 2017 Jun; 188:35-41. PMID: 28577679.
      View in: PubMed
    59. Abdul-Rahim AH, Perez AC, MacIsaac RL, Jhund PS, Claggett BL, Carson PE, Komajda M, McKelvie RS, Zile MR, Swedberg K, Yusuf S, Pfeffer MA, Solomon SD, Lip GYH, Lees KR, McMurray JJV. Risk of stroke in chronic heart failure patients with preserved ejection fraction, but without atrial fibrillation: analysis of the CHARM-Preserved and I-Preserve trials. Eur Heart J. 2017 Mar 07; 38(10):742-750. PMID: 28426886.
      View in: PubMed
    60. Levy WC, Li Y, Reed SD, Zile MR, Shadman R, Dardas T, Whellan DJ, Schulman KA, Ellis SJ, Neilson M, O'Connor CM. Does the Implantable Cardioverter-Defibrillator Benefit Vary With the Estimated Proportional Risk of Sudden Death in Heart Failure Patients? JACC Clin Electrophysiol. 2017 03; 3(3):291-298. PMID: 28553663.
      View in: PubMed
    61. Kristensen SL, Mogensen UM, Jhund PS, Petrie MC, Preiss D, Win S, Køber L, McKelvie RS, Zile MR, Anand IS, Komajda M, Gottdiener JS, Carson PE, McMurray JJ. Clinical and Echocardiographic Characteristics and Cardiovascular Outcomes According to Diabetes Status in Patients With Heart Failure and Preserved Ejection Fraction: A Report From the I-Preserve Trial (Irbesartan in Heart Failure With Preserved Ejection Fraction). Circulation. 2017 Feb 21; 135(8):724-735. PMID: 28052977.
      View in: PubMed
    62. Zile MR, Bennett TD, El Hajj S, Kueffer FJ, Baicu CF, Abraham WT, Bourge RC, Warner Stevenson L. Intracardiac Pressures Measured Using an Implantable Hemodynamic Monitor: Relationship to Mortality in Patients With Chronic Heart Failure. Circ Heart Fail. 2017 Jan; 10(1). PMID: 28062538.
      View in: PubMed
    63. Desai AS, Vardeny O, Claggett B, McMurray JJ, Packer M, Swedberg K, Rouleau JL, Zile MR, Lefkowitz M, Shi V, Solomon SD. Reduced Risk of Hyperkalemia During Treatment of Heart Failure With Mineralocorticoid Receptor Antagonists by Use of Sacubitril/Valsartan Compared With Enalapril: A Secondary Analysis of the PARADIGM-HF Trial. JAMA Cardiol. 2017 01 01; 2(1):79-85. PMID: 27842179.
      View in: PubMed
    64. Ferreira JP, Duarte K, Graves TL, Zile MR, Abraham WT, Weaver FA, Lindenfeld J, Zannad F. Natriuretic Peptides, 6-Min Walk Test, and Quality-of-Life Questionnaires as Clinically Meaningful Endpoints in HF Trials. J Am Coll Cardiol. 2016 Dec 20; 68(24):2690-2707. PMID: 27978953.
      View in: PubMed
    65. Zile MR, Claggett BL, Prescott MF, McMurray JJ, Packer M, Rouleau JL, Swedberg K, Desai AS, Gong J, Shi VC, Solomon SD. Prognostic Implications of Changes in N-Terminal Pro-B-Type Natriuretic Peptide in Patients With Heart Failure. J Am Coll Cardiol. 2016 Dec 06; 68(22):2425-2436. PMID: 27908347.
      View in: PubMed
    66. Nadruz W, Claggett BL, McMurray JJ, Packer M, Zile MR, Rouleau JL, Desai AS, Swedberg K, Lefkowitz M, Shi VC, Prescott MF, Solomon SD. Impact of Body Mass Index on the Accuracy of N-Terminal Pro-Brain Natriuretic Peptide and Brain Natriuretic Peptide for Predicting Outcomes in Patients With Chronic Heart Failure and Reduced Ejection Fraction: Insights From the PARADIGM-HF Study (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial). Circulation. 2016 11 29; 134(22):1785-1787. PMID: 27895026.
      View in: PubMed
    67. Cannon JA, Shen L, Jhund PS, Kristensen SL, Køber L, Chen F, Gong J, Lefkowitz MP, Rouleau JL, Shi VC, Swedberg K, Zile MR, Solomon SD, Packer M, McMurray JJ. Dementia-related adverse events in PARADIGM-HF and other trials in heart failure with reduced ejection fraction. Eur J Heart Fail. 2017 01; 19(1):129-137. PMID: 27868321.
      View in: PubMed
    68. Butler J, Hamo CE, Udelson JE, Pitt B, Yancy C, Shah SJ, Desvigne-Nickens P, Bernstein HS, Clark RL, Depre C, Dinh W, Hamer A, Kay-Mugford P, Kramer F, Lefkowitz M, Lewis K, Maya J, Maybaum S, Patel MJ, Pollack PS, Roessig L, Rotman S, Salsali A, Sims JJ, Senni M, Rosano G, Dunnmon P, Stockbridge N, Anker SD, Zile MR, Gheorghiade M. Exploring New Endpoints for Patients With Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2016 Nov; 9(11). PMID: 27756791.
      View in: PubMed
    69. LeWinter MM, Zile MR. Could Modification of Titin Contribute to an Answer for Heart Failure With Preserved Ejection Fraction? Circulation. 2016 10 11; 134(15):1100-1104. PMID: 27630137.
      View in: PubMed
    70. Okumura N, Jhund PS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Swedberg K, Zile MR, Solomon SD, Packer M, McMurray JJ. Effects of Sacubitril/Valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) According to Background Therapy. Circ Heart Fail. 2016 09; 9(9). PMID: 27618854.
      View in: PubMed
    71. Gaziano TA, Fonarow GC, Claggett B, Chan WW, Deschaseaux-Voinet C, Turner SJ, Rouleau JL, Zile MR, McMurray JJ, Solomon SD. Cost-effectiveness Analysis of Sacubitril/Valsartan vs Enalapril in Patients With Heart Failure and Reduced Ejection Fraction. JAMA Cardiol. 2016 09 01; 1(6):666-72. PMID: 27438344.
      View in: PubMed
    72. Desai AS, Claggett BL, Packer M, Zile MR, Rouleau JL, Swedberg K, Shi V, Lefkowitz M, Starling R, Teerlink J, McMurray JJV, Solomon SD. Influence of Sacubitril/Valsartan (LCZ696) on 30-Day Readmission After Heart Failure Hospitalization. J Am Coll Cardiol. 2016 07 19; 68(3):241-248. PMID: 27417000.
      View in: PubMed
    73. Solomon SD, Claggett B, Packer M, Desai A, Zile MR, Swedberg K, Rouleau J, Shi V, Lefkowitz M, McMurray JJV. Efficacy of Sacubitril/Valsartan Relative to a Prior Decompensation: The PARADIGM-HF Trial. JACC Heart Fail. 2016 10; 4(10):816-822. PMID: 27395349.
      View in: PubMed
    74. Shah SJ, Kitzman DW, Borlaug BA, van Heerebeek L, Zile MR, Kass DA, Paulus WJ. Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap. Circulation. 2016 Jul 05; 134(1):73-90. PMID: 27358439.
      View in: PubMed
    75. Brisco MA, Zile MR, Hanberg JS, Wilson FP, Parikh CR, Coca SG, Tang WH, Testani JM. Relevance of Changes in Serum Creatinine During a Heart Failure Trial of Decongestive Strategies: Insights From the DOSE Trial. J Card Fail. 2016 Oct; 22(10):753-60. PMID: 27374839.
      View in: PubMed
    76. Kristensen SL, Martinez F, Jhund PS, Arango JL, Belohlávek J, Boytsov S, Cabrera W, Gomez E, Hagège AA, Huang J, Kiatchoosakun S, Kim KS, Mendoza I, Senni M, Squire IB, Vinereanu D, Wong RC, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR, Packer M, McMurray JJ. Geographic variations in the PARADIGM-HF heart failure trial. Eur Heart J. 2016 Nov 01; 37(41):3167-3174. PMID: 27354044.
      View in: PubMed
    77. Gandhi PU, Chow SL, Rector TS, Krum H, Gaggin HK, McMurray JJ, Zile MR, Komajda M, McKelvie RS, Carson PE, Januzzi JL, Anand IS. Prognostic Value of Insulin-Like Growth Factor-Binding Protein 7 in Patients with Heart Failure and Preserved Ejection Fraction. J Card Fail. 2017 Jan; 23(1):20-28. PMID: 27317843.
      View in: PubMed
    78. Vardeny O, Claggett B, Packer M, Zile MR, Rouleau J, Swedberg K, Teerlink JR, Desai AS, Lefkowitz M, Shi V, McMurray JJ, Solomon SD. Efficacy of sacubitril/valsartan vs. enalapril at lower than target doses in heart failure with reduced ejection fraction: the PARADIGM-HF trial. Eur J Heart Fail. 2016 Oct; 18(10):1228-1234. PMID: 27283779.
      View in: PubMed
    79. Weaver FA, Abraham WT, Little WC, Butter C, Ducharme A, Halbach M, Klug D, Lovett EG, Madershahian N, Müller-Ehmsen J, Schafer JE, Senni M, Swarup V, Wachter R, Zile MR. Surgical Experience and Long-term Results of Baroreflex Activation Therapy for Heart Failure With Reduced Ejection Fraction. Semin Thorac Cardiovasc Surg. 2016 Summer; 28(2):320-328. PMID: 28043438.
      View in: PubMed
    80. Desai AS, Solomon S, Claggett B, McMurray JJ, Rouleau J, Swedberg K, Zile M, Lefkowitz M, Shi V, Packer M. Factors Associated With Noncompletion During the Run-In Period Before Randomization and Influence on the Estimated Benefit of LCZ696 in the PARADIGM-HF Trial. Circ Heart Fail. 2016 06; 9(6). PMID: 27296397.
      View in: PubMed
    81. Cannon JA, Shen L, Jhund PS, Anand IS, Komajda M, McKelvie RS, Zile MR, Carson PE, McMurray JJ. Clinical outcomes according to QRS duration and morphology in the irbesartan in patients with heart failure and preserved systolic function (I-PRESERVE) trial. Eur J Heart Fail. 2016 08; 18(8):1021-31. PMID: 27194023.
      View in: PubMed
    82. Toba H, de Castro Brás LE, Baicu CF, Zile MR, Lindsey ML, Bradshaw AD. Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium. Am J Physiol Endocrinol Metab. 2016 06 01; 310(11):E1027-35. PMID: 27143554.
      View in: PubMed
    83. Okumura N, Jhund PS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Swedberg K, Zile MR, Solomon SD, Packer M, McMurray JJ. Importance of Clinical Worsening of Heart Failure Treated in the Outpatient Setting: Evidence From the Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial (PARADIGM-HF). Circulation. 2016 Jun 07; 133(23):2254-62. PMID: 27143684.
      View in: PubMed
    84. Brisco MA, Zile MR, Ter Maaten JM, Hanberg JS, Wilson FP, Parikh C, Testani JM. The risk of death associated with proteinuria in heart failure is restricted to patients with an elevated blood urea nitrogen to creatinine ratio. Int J Cardiol. 2016 Jul 15; 215:521-6. PMID: 27153048.
      View in: PubMed
    85. Santos AB, Roca GQ, Claggett B, Sweitzer NK, Shah SJ, Anand IS, Fang JC, Zile MR, Pitt B, Solomon SD, Shah AM. Prognostic Relevance of Left Atrial Dysfunction in Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2016 Apr; 9(4):e002763. PMID: 27056882.
      View in: PubMed
    86. Solomon SD, Claggett B, Desai AS, Packer M, Zile M, Swedberg K, Rouleau JL, Shi VC, Starling RC, Kozan Ö, Dukat A, Lefkowitz MP, McMurray JJ. Influence of Ejection Fraction on Outcomes and Efficacy of Sacubitril/Valsartan (LCZ696) in Heart Failure with Reduced Ejection Fraction: The Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) Trial. Circ Heart Fail. 2016 Mar; 9(3):e002744. PMID: 26915374.
      View in: PubMed
    87. Novgorodov SA, Riley CL, Yu J, Keffler JA, Clarke CJ, Van Laer AO, Baicu CF, Zile MR, Gudz TI. Lactosylceramide contributes to mitochondrial dysfunction in diabetes. J Lipid Res. 2016 Apr; 57(4):546-62. PMID: 26900161.
      View in: PubMed
    88. Zile MR, Jhund PS, Baicu CF, Claggett BL, Pieske B, Voors AA, Prescott MF, Shi V, Lefkowitz M, McMurray JJ, Solomon SD. Plasma Biomarkers Reflecting Profibrotic Processes in Heart Failure With a Preserved Ejection Fraction: Data From the Prospective Comparison of ARNI With ARB on Management of Heart Failure With Preserved Ejection Fraction Study. Circ Heart Fail. 2016 Jan; 9(1). PMID: 26754625.
      View in: PubMed
    89. Kristensen SL, Preiss D, Jhund PS, Squire I, Cardoso JS, Merkely B, Martinez F, Starling RC, Desai AS, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR, McMurray JJ, Packer M. Risk Related to Pre-Diabetes Mellitus and Diabetes Mellitus in Heart Failure With Reduced Ejection Fraction: Insights From Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial. Circ Heart Fail. 2016 Jan; 9(1). PMID: 26754626.
      View in: PubMed
    90. Gallet R, de Couto G, Simsolo E, Valle J, Sun B, Liu W, Tseliou E, Zile MR, Marbán E. Cardiosphere-derived cells reverse heart failure with preserved ejection fraction (HFpEF) in rats by decreasing fibrosis and inflammation. JACC Basic Transl Sci. 2016 Jan-Feb; 1(1-2):14-28. PMID: 27104217.
      View in: PubMed
    91. Vardeny O, Claggett B, Udell JA, Packer M, Zile M, Rouleau J, Swedberg K, Desai AS, Lefkowitz M, Shi V, McMurray JJV, Solomon SD. Influenza Vaccination in Patients With Chronic Heart Failure: The PARADIGM-HF Trial. JACC Heart Fail. 2016 Feb; 4(2):152-158. PMID: 26746371.
      View in: PubMed
    92. Zile MR, Sharma V, Johnson JW, Warman EN, Baicu CF, Bennett TD. Prediction of All-Cause Mortality Based on the Direct Measurement of Intrathoracic Impedance. Circ Heart Fail. 2016 Jan; 9(1):e002543. PMID: 26699393.
      View in: PubMed
    93. Zile MR, Gregg D. Is Biventricular Fibrosis the Mediator of Late Complications in Tetralogy of Fallot? JACC Cardiovasc Imaging. 2016 Jan; 9(1):11-3. PMID: 26684974.
      View in: PubMed
    94. Claggett B, Packer M, McMurray JJ, Swedberg K, Rouleau J, Zile MR, Jhund P, Lefkowitz M, Shi V, Solomon SD. Estimating the Long-Term Treatment Benefits of Sacubitril-Valsartan. N Engl J Med. 2015 Dec 03; 373(23):2289-90. PMID: 26630151.
      View in: PubMed
    95. Simpson J, Jhund PS, Silva Cardoso J, Martinez F, Mosterd A, Ramires F, Rizkala AR, Senni M, Squire I, Gong J, Lefkowitz MP, Shi VC, Desai AS, Rouleau JL, Swedberg K, Zile MR, McMurray JJV, Packer M, Solomon SD. Comparing LCZ696 with enalapril according to baseline risk using the MAGGIC and EMPHASIS-HF risk scores: an analysis of mortality and morbidity in PARADIGM-HF. J Am Coll Cardiol. 2015 Nov 10; 66(19):2059-2071. PMID: 26541915.
      View in: PubMed
    96. Maisel AS, Shah KS, Barnard D, Jaski B, Frivold G, Marais J, Azer M, Miyamoto MI, Lombardo D, Kelsay D, Iqbal N, Taub PR, Kupfer K, Lee E, Clopton P, Zile M, Greenberg B. How B-Type Natriuretic Peptide (BNP) and Body Weight Changes Vary in Heart Failure With Preserved Ejection Fraction Compared With Reduced Ejection Fraction: Secondary Results of the HABIT (HF Assessment With BNP in the Home) Trial. J Card Fail. 2016 Apr; 22(4):283-93. PMID: 26433086.
      View in: PubMed
    97. Saigusa T, Dang Y, Mullick AE, Yeh ST, Zile MR, Baicu CF, Bell PD. Suppressing angiotensinogen synthesis attenuates kidney cyst formation in a Pkd1 mouse model. FASEB J. 2016 Jan; 30(1):370-9. PMID: 26391272.
      View in: PubMed
    98. Renaud L, Harris LG, Mani SK, Kasiganesan H, Chou JC, Baicu CF, Van Laer A, Akerman AW, Stroud RE, Jones JA, Zile MR, Menick DR. HDACs Regulate miR-133a Expression in Pressure Overload-Induced Cardiac Fibrosis. Circ Heart Fail. 2015 Nov; 8(6):1094-104. PMID: 26371176.
      View in: PubMed
    99. Kao DP, Lewsey JD, Anand IS, Massie BM, Zile MR, Carson PE, McKelvie RS, Komajda M, McMurray JJ, Lindenfeld J. Characterization of subgroups of heart failure patients with preserved ejection fraction with possible implications for prognosis and treatment response. Eur J Heart Fail. 2015 Sep; 17(9):925-35. PMID: 26250359.
      View in: PubMed
    100. Jhund PS, Fu M, Bayram E, Chen CH, Negrusz-Kawecka M, Rosenthal A, Desai AS, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR, McMurray JJ, Packer M. Efficacy and safety of LCZ696 (sacubitril-valsartan) according to age: insights from PARADIGM-HF. Eur Heart J. 2015 Oct 07; 36(38):2576-84. PMID: 26231885.
      View in: PubMed
    101. Badar AA, Perez-Moreno AC, Hawkins NM, Jhund PS, Brunton AP, Anand IS, McKelvie RS, Komajda M, Zile MR, Carson PE, Gardner RS, Petrie MC, McMurray JJ. Clinical Characteristics and Outcomes of Patients With Coronary Artery Disease and Angina: Analysis of the Irbesartan in Patients With Heart Failure and Preserved Systolic Function Trial. Circ Heart Fail. 2015 Jul; 8(4):717-24. PMID: 26067854.
      View in: PubMed
    102. Zile MR, Abraham WT, Weaver FA, Butter C, Ducharme A, Halbach M, Klug D, Lovett EG, Müller-Ehmsen J, Schafer JE, Senni M, Swarup V, Wachter R, Little WC. Baroreflex activation therapy for the treatment of heart failure with a reduced ejection fraction: safety and efficacy in patients with and without cardiac resynchronization therapy. Eur J Heart Fail. 2015 Oct; 17(10):1066-74. PMID: 26011593.
      View in: PubMed
    103. Kristensen SL, Jhund PS, Køber L, McKelvie RS, Zile MR, Anand IS, Komajda M, Cleland JGF, Carson PE, McMurray JJV. Relative Importance of History of Heart Failure Hospitalization and N-Terminal Pro-B-Type Natriuretic Peptide Level as Predictors of Outcomes in Patients With Heart Failure and Preserved Ejection Fraction. JACC Heart Fail. 2015 Jun; 3(6):478-486. PMID: 26046842.
      View in: PubMed
    104. Desai AS, McMurray JJ, Packer M, Swedberg K, Rouleau JL, Chen F, Gong J, Rizkala AR, Brahimi A, Claggett B, Finn PV, Hartley LH, Liu J, Lefkowitz M, Shi V, Zile MR, Solomon SD. Effect of the angiotensin-receptor-neprilysin inhibitor LCZ696 compared with enalapril on mode of death in heart failure patients. Eur Heart J. 2015 Aug 07; 36(30):1990-7. PMID: 26022006.
      View in: PubMed
    105. Kheirbek RE, Fletcher RD, Bakitas MA, Fonarow GC, Parvataneni S, Bearden D, Bailey FA, Morgan CJ, Singh S, Blackman MR, Zile MR, Patel K, Ahmed MB, Tucker RO, Brown CJ, Love TE, Aronow WS, Roseman JM, Rich MW, Allman RM, Ahmed A. Discharge Hospice Referral and Lower 30-Day All-Cause Readmission in Medicare Beneficiaries Hospitalized for Heart Failure. Circ Heart Fail. 2015 Jul; 8(4):733-40. PMID: 26019151.
      View in: PubMed
    106. Abraham WT, Zile MR, Weaver FA, Butter C, Ducharme A, Halbach M, Klug D, Lovett EG, Müller-Ehmsen J, Schafer JE, Senni M, Swarup V, Wachter R, Little WC. Baroreflex Activation Therapy for the Treatment of Heart Failure With a Reduced Ejection Fraction. JACC Heart Fail. 2015 Jun; 3(6):487-496. PMID: 25982108.
      View in: PubMed
    107. Carson PE, Anand IS, Win S, Rector T, Haass M, Lopez-Sendon J, Miller A, Teerlink JR, White M, McKelvie RS, Komajda M, Zile MR, McMurray JJ, Massie B. The Hospitalization Burden and Post-Hospitalization Mortality Risk in Heart Failure With Preserved Ejection Fraction: Results From the I-PRESERVE Trial (Irbesartan in Heart Failure and Preserved Ejection Fraction). JACC Heart Fail. 2015 Jun; 3(6):429-441. PMID: 25982110.
      View in: PubMed
    108. Jhund PS, Anand IS, Komajda M, Claggett BL, McKelvie RS, Zile MR, Carson PE, McMurray JJ. Changes in N-terminal pro-B-type natriuretic peptide levels and outcomes in heart failure with preserved ejection fraction: an analysis of the I-Preserve study. Eur J Heart Fail. 2015 Aug; 17(8):809-17. PMID: 25921853.
      View in: PubMed
    109. Sas KM, Yin H, Fitzgibbon WR, Baicu CF, Zile MR, Steele SL, Amria M, Saigusa T, Funk J, Bunni MA, Siegal GP, Siroky BJ, Bissler JJ, Bell PD. Hyperglycemia in the absence of cilia accelerates cystogenesis and induces renal damage. Am J Physiol Renal Physiol. 2015 Jul 01; 309(1):F79-87. PMID: 25904703.
      View in: PubMed
    110. Toba H, de Castro Brás LE, Baicu CF, Zile MR, Lindsey ML, Bradshaw AD. Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization. Am J Physiol Cell Physiol. 2015 Jun 15; 308(12):C972-82. PMID: 25877699.
      View in: PubMed
    111. Saeki M, Sato N, Kawasaki M, Tanaka R, Nagaya M, Watanabe T, Ono K, Noda T, Zile MR, Minatoguchi S. Left ventricular layer function in hypertension assessed by myocardial strain rate using novel one-beat real-time three-dimensional speckle tracking echocardiography with high volume rates. Hypertens Res. 2015 Aug; 38(8):551-9. PMID: 25832918.
      View in: PubMed
    112. Cunningham KF, Beeson GC, Beeson CC, Baicu CF, Zile MR, McDermott PJ. Estrogen-Related Receptor a (ERRa) is required for adaptive increases in PGC-1 isoform expression during electrically stimulated contraction of adult cardiomyocytes in sustained hypoxic conditions. Int J Cardiol. 2015; 187:393-400. PMID: 25841134.
      View in: PubMed
    113. Medeiros K, O'Connor M, Baicu CF, Fitzgibbons T, Shaw P, Tighe DA, Zile MR, Aurigemma GP. Response to letters regarding article, "systolic and diastolic mechanics in stress cardiomyopathy". Circulation. 2015 Mar 10; 131(10):e372. PMID: 25753351.
      View in: PubMed
    114. McMurray J, Packer M, Desai A, Gong J, Greenlaw N, Lefkowitz M, Rizkala A, Shi V, Rouleau J, Solomon S, Swedberg K, Zile MR, Andersen K, Arango JL, Arnold M, Belohlávek J, Böhm M, Boytsov S, Burgess L, Cabrera W, Chen CH, Erglis A, Fu M, Gomez E, Gonzalez A, Hagege AA, Katova T, Kiatchoosakun S, Kim KS, Bayram E, Martinez F, Merkely B, Mendoza I, Mosterd A, Negrusz-Kawecka M, Peuhkurinen K, Ramires F, Refsgaard J, Senni M, Sibulo AS, Silva-Cardoso J, Squire I, Starling RC, Vinereanu D, Teerlink JR, Wong R. A putative placebo analysis of the effects of LCZ696 on clinical outcomes in heart failure. Eur Heart J. 2015 Feb 14; 36(7):434-9. PMID: 25416329.
      View in: PubMed
    115. Voors AA, Gori M, Liu LC, Claggett B, Zile MR, Pieske B, McMurray JJ, Packer M, Shi V, Lefkowitz MP, Solomon SD. Renal effects of the angiotensin receptor neprilysin inhibitor LCZ696 in patients with heart failure and preserved ejection fraction. Eur J Heart Fail. 2015 May; 17(5):510-7. PMID: 25657064.
      View in: PubMed
    116. Zile MR, Baicu CF, Ikonomidis JS, Stroud RE, Nietert PJ, Bradshaw AD, Slater R, Palmer BM, Van Buren P, Meyer M, Redfield MM, Bull DA, Granzier HL, LeWinter MM. Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin. Circulation. 2015 Apr 07; 131(14):1247-59. PMID: 25637629.
      View in: PubMed
    117. Kristensen SL, Jhund PS, Køber L, Preiss D, Kjekshus J, McKelvie RS, Zile MR, Anand IS, Wikstrand J, Wedel H, Komajda M, Carson PE, Cleland JG, McMurray JJ. Comparison of outcomes after hospitalization for worsening heart failure, myocardial infarction, and stroke in patients with heart failure and reduced and preserved ejection fraction. Eur J Heart Fail. 2015 Feb; 17(2):169-76. PMID: 25756844.
      View in: PubMed
    118. Kawasaki M, Tanaka R, Ono K, Minatoguchi S, Watanabe T, Iwama M, Hirose T, Arai M, Noda T, Watanabe S, Zile MR, Minatoguchi S. A novel ultrasound predictor of pulmonary capillary wedge pressure assessed by the combination of left atrial volume and function: A speckle tracking echocardiography study. J Cardiol. 2015 Sep; 66(3):253-62. PMID: 25547741.
      View in: PubMed
    119. Jones LG, Sin MK, Hage FG, Kheirbek RE, Morgan CJ, Zile MR, Wu WC, Deedwania P, Fonarow GC, Aronow WS, Prabhu SD, Fletcher RD, Ahmed A, Allman RM. Characteristics and outcomes of patients with advanced chronic systolic heart failure receiving care at the Veterans Affairs versus other hospitals: insights from the Beta-blocker Evaluation of Survival Trial (BEST). Circ Heart Fail. 2015 Jan; 8(1):17-24. PMID: 25480782.
      View in: PubMed
    120. Kristensen SL, Køber L, Jhund PS, Solomon SD, Kjekshus J, McKelvie RS, Zile MR, Granger CB, Wikstrand J, Komajda M, Carson PE, Pfeffer MA, Swedberg K, Wedel H, Yusuf S, McMurray JJ. International geographic variation in event rates in trials of heart failure with preserved and reduced ejection fraction. Circulation. 2015 Jan 06; 131(1):43-53. PMID: 25406306.
      View in: PubMed
    121. Packer M, McMurray JJ, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile M, Andersen K, Arango JL, Arnold JM, Belohlávek J, Böhm M, Boytsov S, Burgess LJ, Cabrera W, Calvo C, Chen CH, Dukat A, Duarte YC, Erglis A, Fu M, Gomez E, Gonzàlez-Medina A, Hagège AA, Huang J, Katova T, Kiatchoosakun S, Kim KS, Kozan Ö, Llamas EB, Martinez F, Merkely B, Mendoza I, Mosterd A, Negrusz-Kawecka M, Peuhkurinen K, Ramires FJ, Refsgaard J, Rosenthal A, Senni M, Sibulo AS, Silva-Cardoso J, Squire IB, Starling RC, Teerlink JR, Vanhaecke J, Vinereanu D, Wong RC. Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure. Circulation. 2015 Jan 06; 131(1):54-61. PMID: 25403646.
      View in: PubMed
    122. Harris BS, De Cecco CN, Schoepf UJ, Steinberg DH, Bayer RR, Krazinski AW, Dyer KT, Sandhu MK, Zile MR, Meinel FG. Dual-source CT imaging to plan transcatheter aortic valve replacement: accuracy for diagnosis of obstructive coronary artery disease. Radiology. 2015 Apr; 275(1):80-8. PMID: 25393848.
      View in: PubMed
    123. Adabag S, Rector TS, Anand IS, McMurray JJ, Zile M, Komajda M, McKelvie RS, Massie B, Carson PE. A prediction model for sudden cardiac death in patients with heart failure and preserved ejection fraction. Eur J Heart Fail. 2014 Nov; 16(11):1175-82. PMID: 25302657.
      View in: PubMed
    124. Shah AM, Kraigher-Krainer E, Gupta DK, Santos A, Claggett B, Pieske B, Zile MR, Voors AA, Lefkowitz MP, Packer M, McMurray JJ, Solomon SD. Reply: does speckle tracking really improve diagnosis and risk stratification in patients with HF with normal EF? J Am Coll Cardiol. 2014 Oct 07; 64(14):1535-6. PMID: 25277624.
      View in: PubMed
    125. Jhund PS, Claggett BL, Voors AA, Zile MR, Packer M, Pieske BM, Kraigher-Krainer E, Shah AM, Prescott MF, Shi V, Lefkowitz M, McMurray JJ, Solomon SD. Elevation in high-sensitivity troponin T in heart failure and preserved ejection fraction and influence of treatment with the angiotensin receptor neprilysin inhibitor LCZ696. Circ Heart Fail. 2014 Nov; 7(6):953-9. PMID: 25277997.
      View in: PubMed
    126. Damman K, Perez AC, Anand IS, Komajda M, McKelvie RS, Zile MR, Massie B, Carson PE, McMurray JJ. Worsening renal function and outcome in heart failure patients with preserved ejection fraction and the impact of angiotensin receptor blocker treatment. J Am Coll Cardiol. 2014 Sep 16; 64(11):1106-13. PMID: 25212644.
      View in: PubMed
    127. Oluleye OW, Rector TS, Win S, McMurray JJ, Zile MR, Komajda M, McKelvie RS, Massie B, Carson PE, Anand IS. History of atrial fibrillation as a risk factor in patients with heart failure and preserved ejection fraction. Circ Heart Fail. 2014 Nov; 7(6):960-6. PMID: 25225241.
      View in: PubMed
    128. Zile MR, Gaasch WH, Patel K, Aban IB, Ahmed A. Adverse left ventricular remodeling in community-dwelling older adults predicts incident heart failure and mortality. JACC Heart Fail. 2014 Oct; 2(5):512-22. PMID: 25194295.
      View in: PubMed
    129. McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014 Sep 11; 371(11):993-1004. PMID: 25176015.
      View in: PubMed
    130. Santos AB, Kraigher-Krainer E, Gupta DK, Claggett B, Zile MR, Pieske B, Voors AA, Lefkowitz M, Bransford T, Shi V, Packer M, McMurray JJ, Shah AM, Solomon SD. Impaired left atrial function in heart failure with preserved ejection fraction. Eur J Heart Fail. 2014 Oct; 16(10):1096-103. PMID: 25138249.
      View in: PubMed
    131. Shah AM, Claggett B, Sweitzer NK, Shah SJ, Anand IS, O'Meara E, Desai AS, Heitner JF, Li G, Fang J, Rouleau J, Zile MR, Markov V, Ryabov V, Reis G, Assmann SF, McKinlay SM, Pitt B, Pfeffer MA, Solomon SD. Cardiac structure and function and prognosis in heart failure with preserved ejection fraction: findings from the echocardiographic study of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) Trial. Circ Heart Fail. 2014 Sep; 7(5):740-51. PMID: 25122186.
      View in: PubMed
    132. Lieb W, Gona P, Larson MG, Aragam J, Zile MR, Cheng S, Benjamin EJ, Vasan RS. The natural history of left ventricular geometry in the community: clinical correlates and prognostic significance of change in LV geometric pattern. JACC Cardiovasc Imaging. 2014 Sep; 7(9):870-8. PMID: 25129518.
      View in: PubMed
    133. Yarbrough WM, Baicu C, Mukherjee R, Van Laer A, Rivers WT, McKinney RA, Prescott CB, Stroud RE, Freels PD, Zellars KN, Zile MR, Spinale FG. Cardiac-restricted overexpression or deletion of tissue inhibitor of matrix metalloproteinase-4: differential effects on left ventricular structure and function following pressure overload-induced hypertrophy. Am J Physiol Heart Circ Physiol. 2014 Sep 01; 307(5):H752-61. PMID: 24993046.
      View in: PubMed
    134. Gori M, Senni M, Gupta DK, Charytan DM, Kraigher-Krainer E, Pieske B, Claggett B, Shah AM, Santos AB, Zile MR, Voors AA, McMurray JJ, Packer M, Bransford T, Lefkowitz M, Solomon SD. Association between renal function and cardiovascular structure and function in heart failure with preserved ejection fraction. Eur Heart J. 2014 Dec 21; 35(48):3442-51. PMID: 24980489.
      View in: PubMed
    135. McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz M, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR. Baseline characteristics and treatment of patients in prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial (PARADIGM-HF). Eur J Heart Fail. 2014 Jul; 16(7):817-25. PMID: 24828035.
      View in: PubMed
    136. Böhm M, Perez AC, Jhund PS, Reil JC, Komajda M, Zile MR, McKelvie RS, Anand IS, Massie BM, Carson PE, McMurray JJ. Relationship between heart rate and mortality and morbidity in the irbesartan patients with heart failure and preserved systolic function trial (I-Preserve). Eur J Heart Fail. 2014 Jul; 16(7):778-87. PMID: 24864045.
      View in: PubMed
    137. Jhund PS, Claggett B, Packer M, Zile MR, Voors AA, Pieske B, Lefkowitz M, Shi V, Bransford T, McMurray JJ, Solomon SD. Independence of the blood pressure lowering effect and efficacy of the angiotensin receptor neprilysin inhibitor, LCZ696, in patients with heart failure with preserved ejection fraction: an analysis of the PARAMOUNT trial. Eur J Heart Fail. 2014 Jun; 16(6):671-7. PMID: 24692284.
      View in: PubMed
    138. Butler J, Fonarow GC, Zile MR, Lam CS, Roessig L, Schelbert EB, Shah SJ, Ahmed A, Bonow RO, Cleland JG, Cody RJ, Chioncel O, Collins SP, Dunnmon P, Filippatos G, Lefkowitz MP, Marti CN, McMurray JJ, Misselwitz F, Nodari S, O'Connor C, Pfeffer MA, Pieske B, Pitt B, Rosano G, Sabbah HN, Senni M, Solomon SD, Stockbridge N, Teerlink JR, Georgiopoulou VV, Gheorghiade M. Developing therapies for heart failure with preserved ejection fraction: current state and future directions. JACC Heart Fail. 2014 Apr; 2(2):97-112. PMID: 24720916.
      View in: PubMed
    139. de Castro Brás LE, Toba H, Baicu CF, Zile MR, Weintraub ST, Lindsey ML, Bradshaw AD. Age and SPARC change the extracellular matrix composition of the left ventricle. Biomed Res Int. 2014; 2014:810562. PMID: 24783223.
      View in: PubMed
    140. Todoran TM, Basile JN, Zile MR. Renal sympathetic denervation for blood pressure control: a review of the current evidence and ongoing studies. J Clin Hypertens (Greenwich). 2014 May; 16(5):331-41. PMID: 24655555.
      View in: PubMed
    141. Zile MR, Bourge RC, Redfield MM, Zhou D, Baicu CF, Little WC. Randomized, double-blind, placebo-controlled study of sitaxsentan to improve impaired exercise tolerance in patients with heart failure and a preserved ejection fraction. JACC Heart Fail. 2014 Apr; 2(2):123-30. PMID: 24720918.
      View in: PubMed
    142. Gori M, Lam CS, Gupta DK, Santos AB, Cheng S, Shah AM, Claggett B, Zile MR, Kraigher-Krainer E, Pieske B, Voors AA, Packer M, Bransford T, Lefkowitz M, McMurray JJ, Solomon SD. Sex-specific cardiovascular structure and function in heart failure with preserved ejection fraction. Eur J Heart Fail. 2014 May; 16(5):535-42. PMID: 24574260.
      View in: PubMed
    143. Medeiros K, O'Connor MJ, Baicu CF, Fitzgibbons TP, Shaw P, Tighe DA, Zile MR, Aurigemma GP. Systolic and diastolic mechanics in stress cardiomyopathy. Circulation. 2014 Apr 22; 129(16):1659-67. PMID: 24503950.
      View in: PubMed
    144. Goldsmith EC, Bradshaw AD, Zile MR, Spinale FG. Myocardial fibroblast-matrix interactions and potential therapeutic targets. J Mol Cell Cardiol. 2014 May; 70:92-9. PMID: 24472826.
      View in: PubMed
    145. Zile MR, Baicu CF, Stroud RE, Van Laer AO, Jones JA, Patel R, Mukherjee R, Spinale FG. Mechanistic relationship between membrane type-1 matrix metalloproteinase and the myocardial response to pressure overload. Circ Heart Fail. 2014 Mar 01; 7(2):340-50. PMID: 24395927.
      View in: PubMed
    146. Kraigher-Krainer E, Shah AM, Gupta DK, Santos A, Claggett B, Pieske B, Zile MR, Voors AA, Lefkowitz MP, Packer M, McMurray JJ, Solomon SD. Impaired systolic function by strain imaging in heart failure with preserved ejection fraction. J Am Coll Cardiol. 2014 Feb 11; 63(5):447-56. PMID: 24184245.
      View in: PubMed
    147. Santos AB, Kraigher-Krainer E, Bello N, Claggett B, Zile MR, Pieske B, Voors AA, McMurray JJ, Packer M, Bransford T, Lefkowitz M, Shah AM, Solomon SD. Left ventricular dyssynchrony in patients with heart failure and preserved ejection fraction. Eur Heart J. 2014 Jan; 35(1):42-7. PMID: 24164863.
      View in: PubMed
    148. Hashim T, Elbaz S, Patel K, Morgan CJ, Fonarow GC, Fleg JL, McGwin G, Cutter GR, Allman RM, Prabhu SD, Zile MR, Bourge RC, Ahmed A. Digoxin and 30-day all-cause hospital admission in older patients with chronic diastolic heart failure. Am J Med. 2014 Feb; 127(2):132-9. PMID: 24067296.
      View in: PubMed
    149. Spinale FG, Zile MR. Integrating the myocardial matrix into heart failure recognition and management. Circ Res. 2013 Aug 30; 113(6):725-38. PMID: 23989715.
      View in: PubMed
    150. Uraizee I, Cheng S, Hung CL, Verma A, Thomas JD, Zile MR, Aurigemma GP, Solomon SD. Relation of N-terminal pro-B-type natriuretic peptide with diastolic function in hypertensive heart disease. Am J Hypertens. 2013 Oct; 26(10):1234-41. PMID: 23792241.
      View in: PubMed
    151. Zile MR, Baicu CF. Biomarkers of diastolic dysfunction and myocardial fibrosis: application to heart failure with a preserved ejection fraction. J Cardiovasc Transl Res. 2013 Aug; 6(4):501-15. PMID: 23716130.
      View in: PubMed
    152. Todoran TM, Zile MR. Neuromodulation device therapy for treatment of hypertensive heart disease. Circ J. 2013; 77(6):1351-63. PMID: 23657125.
      View in: PubMed
    153. McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau J, Shi VC, Solomon SD, Swedberg K, Zile MR. Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF). Eur J Heart Fail. 2013 Sep; 15(9):1062-73. PMID: 23563576.
      View in: PubMed
    154. Zile MR, Kjellstrom B, Bennett T, Cho Y, Baicu CF, Aaron MF, Abraham WT, Bourge RC, Kueffer FJ. Effects of exercise on left ventricular systolic and diastolic properties in patients with heart failure and a preserved ejection fraction versus heart failure and a reduced ejection fraction. Circ Heart Fail. 2013 May; 6(3):508-16. PMID: 23515277.
      View in: PubMed
    155. Ahmed A, Rich MW, Zile M, Sanders PW, Patel K, Zhang Y, Aban IB, Love TE, Fonarow GC, Aronow WS, Allman RM. Renin-angiotensin inhibition in diastolic heart failure and chronic kidney disease. Am J Med. 2013 Feb; 126(2):150-61. PMID: 23331442.
      View in: PubMed
    156. Spinale FG, Janicki JS, Zile MR. Membrane-associated matrix proteolysis and heart failure. Circ Res. 2013 Jan 04; 112(1):195-208. PMID: 23287455.
      View in: PubMed
    157. Little WC, Zile MR. HFpEF: cardiovascular abnormalities not just comorbidities. Circ Heart Fail. 2012 Nov; 5(6):669-71. PMID: 23170020.
      View in: PubMed
    158. Russo SB, Baicu CF, Van Laer A, Geng T, Kasiganesan H, Zile MR, Cowart LA. Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes. J Clin Invest. 2012 Nov; 122(11):3919-30. PMID: 23023704.
      View in: PubMed
    159. Donaldson C, Palmer BM, Zile M, Maughan DW, Ikonomidis JS, Granzier H, Meyer M, VanBuren P, LeWinter MM. Myosin cross-bridge dynamics in patients with hypertension and concentric left ventricular remodeling. Circ Heart Fail. 2012 Nov; 5(6):803-11. PMID: 23014131.
      View in: PubMed
    160. Balasubramanian S, Quinones L, Kasiganesan H, Zhang Y, Pleasant DL, Sundararaj KP, Zile MR, Bradshaw AD, Kuppuswamy D. ß3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse. PLoS One. 2012; 7(9):e45076. PMID: 22984613.
      View in: PubMed
    161. Lam CS, Shah AM, Borlaug BA, Cheng S, Verma A, Izzo J, Oparil S, Aurigemma GP, Thomas JD, Pitt B, Zile MR, Solomon SD. Effect of antihypertensive therapy on ventricular-arterial mechanics, coupling, and efficiency. Eur Heart J. 2013 Mar; 34(9):676-83. PMID: 22963833.
      View in: PubMed
    162. Baicu CF, Li J, Zhang Y, Kasiganesan H, Cooper G, Zile MR, Bradshaw AD. Time course of right ventricular pressure-overload induced myocardial fibrosis: relationship to changes in fibroblast postsynthetic procollagen processing. Am J Physiol Heart Circ Physiol. 2012 Nov 01; 303(9):H1128-34. PMID: 22942178.
      View in: PubMed
    163. Solomon SD, Zile M, Pieske B, Voors A, Shah A, Kraigher-Krainer E, Shi V, Bransford T, Takeuchi M, Gong J, Lefkowitz M, Packer M, McMurray JJ. The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial. Lancet. 2012 Oct 20; 380(9851):1387-95. PMID: 22932717.
      View in: PubMed
    164. Lam CS, Carson PE, Anand IS, Rector TS, Kuskowski M, Komajda M, McKelvie RS, McMurray JJ, Zile MR, Massie BM, Kitzman DW. Sex differences in clinical characteristics and outcomes in elderly patients with heart failure and preserved ejection fraction: the Irbesartan in Heart Failure with Preserved Ejection Fraction (I-PRESERVE) trial. Circ Heart Fail. 2012 Sep 01; 5(5):571-8. PMID: 22887722.
      View in: PubMed
    165. Reed SD, Li Y, Dunlap ME, Kraus WE, Samsa GP, Schulman KA, Zile MR, Whellan DJ. In-hospital resource use and medical costs in the last year of life by mode of death (from the HF-ACTION randomized controlled trial). Am J Cardiol. 2012 Oct 15; 110(8):1150-5. PMID: 22762718.
      View in: PubMed
    166. Essa EM, Zile MR, Stroud RE, Rice A, Gumina RJ, Leier CV, Spinale FG. Changes in plasma profiles of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in stress-induced cardiomyopathy. J Card Fail. 2012 Jun; 18(6):487-92. PMID: 22633307.
      View in: PubMed
    167. McDermott PJ, Baicu CF, Wahl SR, Van Laer AO, Zile MR. In vivo measurements of the contributions of protein synthesis and protein degradation in regulating cardiac pressure overload hypertrophy in the mouse. Mol Cell Biochem. 2012 Aug; 367(1-2):205-13. PMID: 22610791.
      View in: PubMed
    168. Baicu CF, Zhang Y, Van Laer AO, Renaud L, Zile MR, Bradshaw AD. Effects of the absence of procollagen C-endopeptidase enhancer-2 on myocardial collagen accumulation in chronic pressure overload. Am J Physiol Heart Circ Physiol. 2012 Jul 15; 303(2):H234-40. PMID: 22610170.
      View in: PubMed
    169. Zile MR, Little WC. Effects of autonomic modulation: more than just blood pressure. J Am Coll Cardiol. 2012 Mar 06; 59(10):910-2. PMID: 22381426.
      View in: PubMed
    170. Teerlink JR, Iragui VJ, Mohr JP, Carson PE, Hauptman PJ, Lovett DH, Miller AB, Piña IL, Thomson S, Varosy PD, Zile MR, Cleland JG, Givertz MM, Metra M, Ponikowski P, Voors AA, Davison BA, Cotter G, Wolko D, Delucca P, Salerno CM, Mansoor GA, Dittrich H, O'Connor CM, Massie BM. The safety of an adenosine A(1)-receptor antagonist, rolofylline, in patients with acute heart failure and renal impairment: findings from PROTECT. Drug Saf. 2012 Mar 01; 35(3):233-44. PMID: 22339573.
      View in: PubMed
    171. Greenberg BH, Anand IS, Burnett JC, Chin J, Dracup KA, Feldman AM, Force T, Francis GS, Houser SR, Hunt SA, Konstam MA, Lindenfeld J, Mann DL, Mehra MR, Paul SC, Piano MR, Ross HJ, Sabbah HN, Starling RC, Udelson JE, Yancy CW, Zile MR, Massie BM. The Heart Failure Society of America in 2020: a vision for the future. J Card Fail. 2012 Feb; 18(2):90-3. PMID: 22300775.
      View in: PubMed
    172. Zile MR, Baicu CF, Stroud RE, Van Laer A, Arroyo J, Mukherjee R, Jones JA, Spinale FG. Pressure overload-dependent membrane type 1-matrix metalloproteinase induction: relationship to LV remodeling and fibrosis. Am J Physiol Heart Circ Physiol. 2012 Apr 01; 302(7):H1429-37. PMID: 22287584.
      View in: PubMed
    173. Rector TS, Carson PE, Anand IS, McMurray JJ, Zile MR, McKelvie RS, Komajda M, Kuskowski M, Massie BM. Assessment of long-term effects of irbesartan on heart failure with preserved ejection fraction as measured by the minnesota living with heart failure questionnaire in the irbesartan in heart failure with preserved systolic function (I-PRESERVE) trial. Circ Heart Fail. 2012 Mar 01; 5(2):217-25. PMID: 22267751.
      View in: PubMed
    174. Zile MR, Gottdiener JS, Hetzel SJ, McMurray JJ, Komajda M, McKelvie R, Baicu CF, Massie BM, Carson PE. Prevalence and significance of alterations in cardiac structure and function in patients with heart failure and a preserved ejection fraction. Circulation. 2011 Dec 06; 124(23):2491-501. PMID: 22064591.
      View in: PubMed
    175. Yarbrough WM, Mukherjee R, Stroud RE, Rivers WT, Oelsen JM, Dixon JA, Eckhouse SR, Ikonomidis JS, Zile MR, Spinale FG. Progressive induction of left ventricular pressure overload in a large animal model elicits myocardial remodeling and a unique matrix signature. J Thorac Cardiovasc Surg. 2012 Jan; 143(1):215-23. PMID: 22056365.
      View in: PubMed
    176. Gaasch WH, Zile MR. Left ventricular structural remodeling in health and disease: with special emphasis on volume, mass, and geometry. J Am Coll Cardiol. 2011 Oct 18; 58(17):1733-40. PMID: 21996383.
      View in: PubMed
    177. Zile MR, Mehurg SM, Arroyo JE, Stroud RE, DeSantis SM, Spinale FG. Relationship between the temporal profile of plasma microRNA and left ventricular remodeling in patients after myocardial infarction. Circ Cardiovasc Genet. 2011 Dec; 4(6):614-9. PMID: 21956146.
      View in: PubMed
    178. Shah AM, Lam CS, Cheng S, Verma A, Desai AS, Rocha RA, Hilkert R, Izzo J, Oparil S, Pitt B, Thomas JD, Zile MR, Aurigemma GP, Solomon SD. The relationship between renal impairment and left ventricular structure, function, and ventricular-arterial interaction in hypertension. J Hypertens. 2011 Sep; 29(9):1829-36. PMID: 21799444.
      View in: PubMed
    179. Adamson PB, Gold MR, Bennett T, Bourge RC, Stevenson LW, Trupp R, Stromberg K, Wilkoff BL, Costanzo MR, Luby A, Aranda JM, Heywood JT, Baldwin HA, Aaron M, Smith A, Zile M. Continuous hemodynamic monitoring in patients with mild to moderate heart failure: results of The Reducing Decompensation Events Utilizing Intracardiac Pressures in Patients With Chronic Heart Failure (REDUCEhf) trial. Congest Heart Fail. 2011 Sep-Oct; 17(5):248-54. PMID: 21906250.
      View in: PubMed
    180. Yarbrough WM, Mukherjee R, Ikonomidis JS, Zile MR, Spinale FG. Myocardial remodeling with aortic stenosis and after aortic valve replacement: mechanisms and future prognostic implications. J Thorac Cardiovasc Surg. 2012 Mar; 143(3):656-64. PMID: 21762938.
      View in: PubMed
    181. Krum H, Elsik M, Schneider HG, Ptaszynska A, Black M, Carson PE, Komajda M, Massie BM, McKelvie RS, McMurray JJ, Zile MR, Anand IS. Relation of peripheral collagen markers to death and hospitalization in patients with heart failure and preserved ejection fraction: results of the I-PRESERVE collagen substudy. Circ Heart Fail. 2011 Sep; 4(5):561-8. PMID: 21750125.
      View in: PubMed
    182. Zile MR, Gaasch WH. Abnormal calcium homeostasis: one mechanism in diastolic heart failure. J Am Coll Cardiol. 2011 Jul 05; 58(2):155-7. PMID: 21718912.
      View in: PubMed
    183. Anand IS, Rector TS, Cleland JG, Kuskowski M, McKelvie RS, Persson H, McMurray JJ, Zile MR, Komajda M, Massie BM, Carson PE. Prognostic value of baseline plasma amino-terminal pro-brain natriuretic peptide and its interactions with irbesartan treatment effects in patients with heart failure and preserved ejection fraction: findings from the I-PRESERVE trial. Circ Heart Fail. 2011 Sep; 4(5):569-77. PMID: 21715583.
      View in: PubMed
    184. Perry GJ, Ahmed MI, Desai RV, Mujib M, Zile M, Sui X, Aban IB, Zhang Y, Tallaj J, Allman RM, Aronow WS, Fleg JL, Ahmed A. Left ventricular diastolic function and exercise capacity in community-dwelling adults =65 years of age without heart failure. Am J Cardiol. 2011 Sep 01; 108(5):735-40. PMID: 21704282.
      View in: PubMed
    185. Adamson PB, Zile MR, Cho YK, Bennett TD, Bourge RC, Aaron MF, Aranda JM, Abraham WT, Kueffer FJ, Taepke RT. Hemodynamic factors associated with acute decompensated heart failure: part 2--use in automated detection. J Card Fail. 2011 May; 17(5):366-73. PMID: 21549292.
      View in: PubMed
    186. Zile MR, Adamson PB, Cho YK, Bennett TD, Bourge RC, Aaron MF, Aranda JM, Abraham WT, Stevenson LW, Kueffer FJ. Hemodynamic factors associated with acute decompensated heart failure: part 1--insights into pathophysiology. J Card Fail. 2011 Apr; 17(4):282-91. PMID: 21440865.
      View in: PubMed
    187. Harston RK, McKillop JC, Moschella PC, Van Laer A, Quinones LS, Baicu CF, Balasubramanian S, Zile MR, Kuppuswamy D. Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium. Am J Physiol Heart Circ Physiol. 2011 May; 300(5):H1696-706. PMID: 21357504.
      View in: PubMed
    188. Zile MR, Desantis SM, Baicu CF, Stroud RE, Thompson SB, McClure CD, Mehurg SM, Spinale FG. Plasma biomarkers that reflect determinants of matrix composition identify the presence of left ventricular hypertrophy and diastolic heart failure. Circ Heart Fail. 2011 May; 4(3):246-56. PMID: 21350055.
      View in: PubMed
    189. Haass M, Kitzman DW, Anand IS, Miller A, Zile MR, Massie BM, Carson PE. Body mass index and adverse cardiovascular outcomes in heart failure patients with preserved ejection fraction: results from the Irbesartan in Heart Failure with Preserved Ejection Fraction (I-PRESERVE) trial. Circ Heart Fail. 2011 May; 4(3):324-31. PMID: 21350053.
      View in: PubMed
    190. Desai RV, Ahmed MI, Mujib M, Aban IB, Zile MR, Ahmed A. Natural history of concentric left ventricular geometry in community-dwelling older adults without heart failure during seven years of follow-up. Am J Cardiol. 2011 Jan 15; 107(2):321-4. PMID: 21129719.
      View in: PubMed
    191. Komajda M, Carson PE, Hetzel S, McKelvie R, McMurray J, Ptaszynska A, Zile MR, Demets D, Massie BM. Factors associated with outcome in heart failure with preserved ejection fraction: findings from the Irbesartan in Heart Failure with Preserved Ejection Fraction Study (I-PRESERVE). Circ Heart Fail. 2011 Jan; 4(1):27-35. PMID: 21068341.
      View in: PubMed
    192. Georgakopoulos D, Little WC, Abraham WT, Weaver FA, Zile MR. Chronic baroreflex activation: a potential therapeutic approach to heart failure with preserved ejection fraction. J Card Fail. 2011 Feb; 17(2):167-78. PMID: 21300307.
      View in: PubMed
    193. Stevenson LW, Zile M, Bennett TD, Kueffer FJ, Jessup ML, Adamson P, Abraham WT, Manda V, Bourge RC. Chronic ambulatory intracardiac pressures and future heart failure events. Circ Heart Fail. 2010 Sep; 3(5):580-7. PMID: 20562255.
      View in: PubMed
    194. Donaldson C, Taatjes DJ, Zile M, Palmer B, VanBuren P, Spinale F, Maughan D, Von Turkovich M, Bishop N, LeWinter MM. Combined immunoelectron microscopic and computer-assisted image analyses to detect advanced glycation end-products in human myocardium. Histochem Cell Biol. 2010 Jul; 134(1):23-30. PMID: 20490536.
      View in: PubMed
    195. Zile MR, Gaasch WH, Anand IS, Haass M, Little WC, Miller AB, Lopez-Sendon J, Teerlink JR, White M, McMurray JJ, Komajda M, McKelvie R, Ptaszynska A, Hetzel SJ, Massie BM, Carson PE. Mode of death in patients with heart failure and a preserved ejection fraction: results from the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) trial. Circulation. 2010 Mar 30; 121(12):1393-405. PMID: 20231531.
      View in: PubMed
    196. Zile MR, Colombo PC, Mehra M, Greenberg B, Brown S, Konstam MA. Progressive improvement in cardiac performance with continuous aortic flow augmentation (aortic flow therapy) in patients hospitalized with severe heart failure: results of the Multicenter Trial of the Orqis Medical Cancion System for the Enhanced Treatment of Heart Failure Unresponsive to Medical Therapy (MOMENTUM). J Heart Lung Transplant. 2010 Jan; 29(1):86-92. PMID: 20123246.
      View in: PubMed
    197. Bradshaw AD, Baicu CF, Rentz TJ, Van Laer AO, Bonnema DD, Zile MR. Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing. Am J Physiol Heart Circ Physiol. 2010 Feb; 298(2):H614-22. PMID: 20008277.
      View in: PubMed
    198. Gaasch WH, Delorey DE, Kueffer FJ, Zile MR. Distribution of left ventricular ejection fraction in patients with ischemic and hypertensive heart disease and chronic heart failure. Am J Cardiol. 2009 Nov 15; 104(10):1413-5. PMID: 19892060.
      View in: PubMed
    199. McKelvie RS, Komajda M, McMurray J, Zile M, Ptaszynska A, Donovan M, Carson P, Massie BM. Baseline plasma NT-proBNP and clinical characteristics: results from the irbesartan in heart failure with preserved ejection fraction trial. J Card Fail. 2010 Feb; 16(2):128-34. PMID: 20142024.
      View in: PubMed
    200. Mani SK, Balasubramanian S, Zavadzkas JA, Jeffords LB, Rivers WT, Zile MR, Mukherjee R, Spinale FG, Kuppuswamy D. Calpain inhibition preserves myocardial structure and function following myocardial infarction. Am J Physiol Heart Circ Physiol. 2009 Nov; 297(5):H1744-51. PMID: 19734364.
      View in: PubMed
    201. Grant JE, Bradshaw AD, Schwacke JH, Baicu CF, Zile MR, Schey KL. Quantification of protein expression changes in the aging left ventricle of Rattus norvegicus. J Proteome Res. 2009 Sep; 8(9):4252-63. PMID: 19603826.
      View in: PubMed
    202. Xu T, Baicu C, Aho M, Zile M, Boland T. Fabrication and characterization of bio-engineered cardiac pseudo tissues. Biofabrication. 2009 Sep; 1(3):035001. PMID: 20811105.
      View in: PubMed
    203. Johnston RK, Balasubramanian S, Kasiganesan H, Baicu CF, Zile MR, Kuppuswamy D. Beta3 integrin-mediated ubiquitination activates survival signaling during myocardial hypertrophy. FASEB J. 2009 Aug; 23(8):2759-71. PMID: 19364763.
      View in: PubMed
    204. Bradshaw AD, Baicu CF, Rentz TJ, Van Laer AO, Boggs J, Lacy JM, Zile MR. Pressure overload-induced alterations in fibrillar collagen content and myocardial diastolic function: role of secreted protein acidic and rich in cysteine (SPARC) in post-synthetic procollagen processing. Circulation. 2009 Jan 20; 119(2):269-80. PMID: 19118257.
      View in: PubMed
    205. Massie BM, Carson PE, McMurray JJ, Komajda M, McKelvie R, Zile MR, Anderson S, Donovan M, Iverson E, Staiger C, Ptaszynska A. Irbesartan in patients with heart failure and preserved ejection fraction. N Engl J Med. 2008 Dec 04; 359(23):2456-67. PMID: 19001508.
      View in: PubMed
    206. Zile MR, Bennett TD, St John Sutton M, Cho YK, Adamson PB, Aaron MF, Aranda JM, Abraham WT, Smart FW, Stevenson LW, Kueffer FJ, Bourge RC. Transition from chronic compensated to acute decompensated heart failure: pathophysiological insights obtained from continuous monitoring of intracardiac pressures. Circulation. 2008 Sep 30; 118(14):1433-41. PMID: 18794390.
      View in: PubMed
    207. Zile MR, Bourge RC, Bennett TD, Stevenson LW, Cho YK, Adamson PB, Aaron MF, Aranda JM, Abraham WT, Smart FW, Kueffer FJ. Application of implantable hemodynamic monitoring in the management of patients with diastolic heart failure: a subgroup analysis of the COMPASS-HF trial. J Card Fail. 2008 Dec; 14(10):816-23. PMID: 19041044.
      View in: PubMed
    208. Greenberg B, Czerska B, Delgado RM, Bourge R, Zile MR, Silver M, Klapholz M, Haeusslein E, Mehra MR, Mather P, Abraham WT, Neaton JD, Brown BS, Parker IC, Konstam MA. Effects of continuous aortic flow augmentation in patients with exacerbation of heart failure inadequately responsive to medical therapy: results of the Multicenter Trial of the Orqis Medical Cancion System for the Enhanced Treatment of Heart Failure Unresponsive to Medical Therapy (MOMENTUM). Circulation. 2008 Sep 16; 118(12):1241-9. PMID: 18765394.
      View in: PubMed
    209. Willey CD, Palanisamy AP, Johnston RK, Mani SK, Shiraishi H, Tuxworth WJ, Zile MR, Balasubramanian S, Kuppuswamy D. STAT3 activation in pressure-overloaded feline myocardium: role for integrins and the tyrosine kinase BMX. Int J Biol Sci. 2008 Jun 27; 4(3):184-99. PMID: 18612371.
      View in: PubMed
    210. Farr MJ, Lang CC, Lamanca JJ, Zile MR, Francis G, Tavazzi L, Gaasch WH, St John Sutton M, Itoh H, Mancini D. Cardiopulmonary exercise variables in diastolic versus systolic heart failure. Am J Cardiol. 2008 Jul 15; 102(2):203-6. PMID: 18602522.
      View in: PubMed
    211. Gaasch WH, Delorey DE, St John Sutton MG, Zile MR. Patterns of structural and functional remodeling of the left ventricle in chronic heart failure. Am J Cardiol. 2008 Aug 15; 102(4):459-62. PMID: 18678306.
      View in: PubMed
    212. Mani SK, Shiraishi H, Balasubramanian S, Yamane K, Chellaiah M, Cooper G, Banik N, Zile MR, Kuppuswamy D. In vivo administration of calpeptin attenuates calpain activation and cardiomyocyte loss in pressure-overloaded feline myocardium. Am J Physiol Heart Circ Physiol. 2008 Jul; 295(1):H314-26. PMID: 18487434.
      View in: PubMed
    213. Bourge RC, Abraham WT, Adamson PB, Aaron MF, Aranda JM, Magalski A, Zile MR, Smith AL, Smart FW, O'Shaughnessy MA, Jessup ML, Sparks B, Naftel DL, Stevenson LW. Randomized controlled trial of an implantable continuous hemodynamic monitor in patients with advanced heart failure: the COMPASS-HF study. J Am Coll Cardiol. 2008 Mar 18; 51(11):1073-9. PMID: 18342224.
      View in: PubMed
    214. Cheng G, Zile MR, Takahashi M, Baicu CF, Bonnema DD, Cabral F, Menick DR, Cooper G. A direct test of the hypothesis that increased microtubule network density contributes to contractile dysfunction of the hypertrophied heart. Am J Physiol Heart Circ Physiol. 2008 May; 294(5):H2231-41. PMID: 18344371.
      View in: PubMed
    215. McMurray JJ, Carson PE, Komajda M, McKelvie R, Zile MR, Ptaszynska A, Staiger C, Donovan JM, Massie BM. Heart failure with preserved ejection fraction: clinical characteristics of 4133 patients enrolled in the I-PRESERVE trial. Eur J Heart Fail. 2008 Feb; 10(2):149-56. PMID: 18279770.
      View in: PubMed
    216. Jang IK, Weissman NJ, Picard MH, Zile MR, Pettigrew V, Shen S, Tatsuno J, Hibberd MG, Tzivoni D, Wackers FJ. A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: Evaluation of MCC-135 for left ventricular salvage in acute myocardial infarction (EVOLVE). Am Heart J. 2008 Jan; 155(1):113.e1-8. PMID: 18082500.
      View in: PubMed
    217. Spruill LS, Baicu CF, Zile MR, McDermott PJ. Selective translation of mRNAs in the left ventricular myocardium of the mouse in response to acute pressure overload. J Mol Cell Cardiol. 2008 Jan; 44(1):69-75. PMID: 18036610.
      View in: PubMed
    218. Bonnema DD, Webb CS, Pennington WR, Stroud RE, Leonardi AE, Clark LL, McClure CD, Finklea L, Spinale FG, Zile MR. Effects of age on plasma matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs). J Card Fail. 2007 Sep; 13(7):530-40. PMID: 17826643.
      View in: PubMed
    219. Solomon SD, Janardhanan R, Verma A, Bourgoun M, Daley WL, Purkayastha D, Lacourcière Y, Hippler SE, Fields H, Naqvi TZ, Mulvagh SL, Arnold JM, Thomas JD, Zile MR, Aurigemma GP. Effect of angiotensin receptor blockade and antihypertensive drugs on diastolic function in patients with hypertension and diastolic dysfunction: a randomised trial. Lancet. 2007 Jun 23; 369(9579):2079-87. PMID: 17586303.
      View in: PubMed
    220. Zile MR, Lewinter MM. Left ventricular end-diastolic volume is normal in patients with heart failure and a normal ejection fraction: a renewed consensus in diastolic heart failure. J Am Coll Cardiol. 2007 Mar 06; 49(9):982-5. PMID: 17336722.
      View in: PubMed
    221. Goodroe R, Bonnema DD, Lunsford S, Anderson P, Ryan-Baille B, Uber W, Ikonomidis J, Crumbley AJ, VanBakel A, Zile MR, Pereira N. Severe left ventricular hypertrophy 1 year after transplant predicts mortality in cardiac transplant recipients. J Heart Lung Transplant. 2007 Feb; 26(2):145-51. PMID: 17258148.
      View in: PubMed
    222. Ahmed A, Zile MR, Rich MW, Fleg JL, Adams KF, Love TE, Young JB, Aronow WS, Kitzman DW, Gheorghiade M, Dell'Italia LJ. Hospitalizations due to unstable angina pectoris in diastolic and systolic heart failure. Am J Cardiol. 2007 Feb 15; 99(4):460-4. PMID: 17293184.
      View in: PubMed
    223. Ahmed A, Rich MW, Sanders PW, Perry GJ, Bakris GL, Zile MR, Love TE, Aban IB, Shlipak MG. Chronic kidney disease associated mortality in diastolic versus systolic heart failure: a propensity matched study. Am J Cardiol. 2007 Feb 01; 99(3):393-8. PMID: 17261405.
      View in: PubMed
    224. Pereira NL, Zile MR, Harley RA, Van Bakel AB. Myocardial mechanisms causing heart failure early after cardiac transplantation. Transplant Proc. 2006 Nov; 38(9):2999-3003. PMID: 17112884.
      View in: PubMed
    225. Xu L, Renaud L, Müller JG, Baicu CF, Bonnema DD, Zhou H, Kappler CS, Kubalak SW, Zile MR, Conway SJ, Menick DR. Regulation of Ncx1 expression. Identification of regulatory elements mediating cardiac-specific expression and up-regulation. J Biol Chem. 2006 Nov 10; 281(45):34430-40. PMID: 16966329.
      View in: PubMed
    226. Webb CS, Bonnema DD, Ahmed SH, Leonardi AH, McClure CD, Clark LL, Stroud RE, Corn WC, Finklea L, Zile MR, Spinale FG. Specific temporal profile of matrix metalloproteinase release occurs in patients after myocardial infarction: relation to left ventricular remodeling. Circulation. 2006 Sep 05; 114(10):1020-7. PMID: 16923753.
      View in: PubMed
    227. Janardhanan R, Daley WL, Naqvi TZ, Mulvagh SL, Aurigemma G, Zile M, Arnold JM, Artis E, Purkayastha D, Thomas JD, Solomon SD. Rationale and design: the VALsartan In Diastolic Dysfunction (VALIDD) Trial: evolving the management of diastolic dysfunction in hypertension. Am Heart J. 2006 Aug; 152(2):246-52. PMID: 16875904.
      View in: PubMed
    228. Ahmed A, Rich MW, Fleg JL, Zile MR, Young JB, Kitzman DW, Love TE, Aronow WS, Adams KF, Gheorghiade M. Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis investigation group trial. Circulation. 2006 Aug 01; 114(5):397-403. PMID: 16864724.
      View in: PubMed
    229. Bland AM, D'Eugenio LR, Dugan MA, Janech MG, Almeida JS, Zile MR, Arthur JM. Comparison of variability associated with sample preparation in two-dimensional gel electrophoresis of cardiac tissue. J Biomol Tech. 2006 Jul; 17(3):195-9. PMID: 16870710.
      View in: PubMed
    230. Little WC, Zile MR, Klein A, Appleton CP, Kitzman DW, Wesley-Farrington DJ. Effect of losartan and hydrochlorothiazide on exercise tolerance in exertional hypertension and left ventricular diastolic dysfunction. Am J Cardiol. 2006 Aug 01; 98(3):383-5. PMID: 16860028.
      View in: PubMed
    231. Quiñones MA, Zile MR, Massie BM, Kass DA. Chronic heart failure: a report from the Dartmouth Diastole Discourses. Congest Heart Fail. 2006 May-Jun; 12(3):162-5. PMID: 16760702.
      View in: PubMed
    232. Katz AM, Zile MR. New molecular mechanism in diastolic heart failure. Circulation. 2006 Apr 25; 113(16):1922-5. PMID: 16636184.
      View in: PubMed
    233. Ahmed SH, Clark LL, Pennington WR, Webb CS, Bonnema DD, Leonardi AH, McClure CD, Spinale FG, Zile MR. Matrix metalloproteinases/tissue inhibitors of metalloproteinases: relationship between changes in proteolytic determinants of matrix composition and structural, functional, and clinical manifestations of hypertensive heart disease. Circulation. 2006 May 02; 113(17):2089-96. PMID: 16636176.
      View in: PubMed
    234. Lindsey ML, Goshorn DK, Comte-Walters S, Hendrick JW, Hapke E, Zile MR, Schey K. A multidimensional proteomic approach to identify hypertrophy-associated proteins. Proteomics. 2006 Apr; 6(7):2225-35. PMID: 16493702.
      View in: PubMed
    235. Clark LL, Ikonomidis JS, Crawford FA, Crumbley A, Kratz JM, Stroud MR, Woolson RF, Bruce JJ, Nicholas JS, Lackland DT, Zile MR, Spinale FG. Preoperative statin treatment is associated with reduced postoperative mortality and morbidity in patients undergoing cardiac surgery: an 8-year retrospective cohort study. J Thorac Cardiovasc Surg. 2006 Mar; 131(3):679-85. PMID: 16515923.
      View in: PubMed
    236. Aurigemma GP, Zile MR, Gaasch WH. Contractile behavior of the left ventricle in diastolic heart failure: with emphasis on regional systolic function. Circulation. 2006 Jan 17; 113(2):296-304. PMID: 16418449.
      View in: PubMed
    237. Jang IK, Pettigrew V, Picard MH, Kowey PR, Demmel V, Zile MR, Tatsuno J, Wackers FJ, Hibberd M. A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: rationale and design of the evaluation of MCC-135 for left ventricular salvage in acute MI (EVOLVE) study. J Thromb Thrombolysis. 2005 Dec; 20(3):147-53. PMID: 16261287.
      View in: PubMed
    238. Konstam MA, Czerska B, Böhm M, Oren RM, Sadowski J, Khanal S, Abraham WT, Wasler A, Dahm JB, Gavazzi A, Gradinac S, Legrand V, Mohacsi P, Poelzl G, Radovancevic B, Van Bakel AB, Zile MR, Cabuay B, Bartus K, Jansen P. Continuous aortic flow augmentation: a pilot study of hemodynamic and renal responses to a novel percutaneous intervention in decompensated heart failure. Circulation. 2005 Nov 15; 112(20):3107-14. PMID: 16275867.
      View in: PubMed
    239. Peura JL, Zile MR, Feldman DS, VanBakel AB, McClure C, Uber W, Haynes H, Pereira NL. Effects of conversion from cyclosporine to tacrolimus on left ventricular structure in cardiac allograft recipients. J Heart Lung Transplant. 2005 Nov; 24(11):1969-72. PMID: 16297806.
      View in: PubMed
    240. Carson P, Massie BM, McKelvie R, McMurray J, Komajda M, Zile M, Ptaszynska A, Frangin G. The irbesartan in heart failure with preserved systolic function (I-PRESERVE) trial: rationale and design. J Card Fail. 2005 Oct; 11(8):576-85. PMID: 16230259.
      View in: PubMed
    241. Zile MR. Treating diastolic heart failure with statins: "phat" chance for pleiotropic benefits. Circulation. 2005 Jul 19; 112(3):300-3. PMID: 16027268.
      View in: PubMed
    242. Baicu CF, Zile MR, Aurigemma GP, Gaasch WH. Left ventricular systolic performance, function, and contractility in patients with diastolic heart failure. Circulation. 2005 May 10; 111(18):2306-12. PMID: 15851588.
      View in: PubMed
    243. Little WC, Zile MR, Kitzman DW, Hundley WG, O'Brien TX, Degroof RC. The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure. J Card Fail. 2005 Apr; 11(3):191-5. PMID: 15812746.
      View in: PubMed
    244. Stroud RE, Deschamps AM, Lowry AS, Hardin AE, Mukherjee R, Lindsey ML, Ramamoorthy S, Zile MR, Spencer WH, Spinale FG. Plasma monitoring of the myocardial specific tissue inhibitor of metalloproteinase-4 after alcohol septal ablation in hypertrophic obstructive cardiomyopathy. J Card Fail. 2005 Mar; 11(2):124-30. PMID: 15732032.
      View in: PubMed
    245. Zile MR, Baicu CF, Bonnema DD. Diastolic heart failure: definitions and terminology. Prog Cardiovasc Dis. 2005 Mar-Apr; 47(5):307-13. PMID: 16003645.
      View in: PubMed
    246. Ikonomidis JS, Hendrick JW, Parkhurst AM, Herron AR, Escobar PG, Dowdy KB, Stroud RE, Hapke E, Zile MR, Spinale FG. Accelerated LV remodeling after myocardial infarction in TIMP-1-deficient mice: effects of exogenous MMP inhibition. Am J Physiol Heart Circ Physiol. 2005 Jan; 288(1):H149-58. PMID: 15598866.
      View in: PubMed
    247. Aurigemma GP, Zile MR, Gaasch WH. Lack of relationship between Doppler indices of diastolic function and left ventricular pressure transients in patients with definite diastolic heart failure. Am Heart J. 2004 Sep; 148(3):E12. PMID: 15389248.
      View in: PubMed
    248. Zile M, Gaasch W, Little W, Francis G, Tavazzi L, Cleland J, Davies M. A phase II, double-blind, randomized, placebo-controlled, dose comparative study of the efficacy, tolerability, and safety of MCC-135 in subjects with chronic heart failure, NYHA class II/III (MCC-135-GO1 study): rationale and design. J Card Fail. 2004 Jun; 10(3):193-9. PMID: 15190528.
      View in: PubMed
    249. Zile MR, Baicu CF, Gaasch WH. Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle. N Engl J Med. 2004 May 06; 350(19):1953-9. PMID: 15128895.
      View in: PubMed
    250. Gaasch WH, Zile MR. Left ventricular diastolic dysfunction and diastolic heart failure. Annu Rev Med. 2004; 55:373-94. PMID: 14746527.
      View in: PubMed
    251. Yost MJ, Baicu CF, Stonerock CE, Goodwin RL, Price RL, Davis JM, Evans H, Watson PD, Gore CM, Sweet J, Creech L, Zile MR, Terracio L. A novel tubular scaffold for cardiovascular tissue engineering. Tissue Eng. 2004 Jan-Feb; 10(1-2):273-84. PMID: 15009952.
      View in: PubMed
    252. Domanski MJ, Krause-Steinrauf H, Massie BM, Deedwania P, Follmann D, Kovar D, Murray D, Oren R, Rosenberg Y, Young J, Zile M, Eichhorn E. A comparative analysis of the results from 4 trials of beta-blocker therapy for heart failure: BEST, CIBIS-II, MERIT-HF, and COPERNICUS. J Card Fail. 2003 Oct; 9(5):354-63. PMID: 14583895.
      View in: PubMed
    253. Ishibashi Y, Takahashi M, Isomatsu Y, Qiao F, Iijima Y, Shiraishi H, Simsic JM, Baicu CF, Robbins J, Zile MR, Cooper G. Role of microtubules versus myosin heavy chain isoforms in contractile dysfunction of hypertrophied murine cardiocytes. Am J Physiol Heart Circ Physiol. 2003 Sep; 285(3):H1270-85. PMID: 12750067.
      View in: PubMed
    254. Zile MR. Heart failure with preserved ejection fraction: is this diastolic heart failure? J Am Coll Cardiol. 2003 May 07; 41(9):1519-22. PMID: 12742292.
      View in: PubMed
    255. Zile MR, Gaasch WH. Heart failure in aortic stenosis - improving diagnosis and treatment. N Engl J Med. 2003 May 01; 348(18):1735-6. PMID: 12724478.
      View in: PubMed
    256. Zile MR. Diastolic heart failure. Diagnosis, prognosis, treatment. Minerva Cardioangiol. 2003 Apr; 51(2):131-42. PMID: 12783069.
      View in: PubMed
    257. Zile MR. Peter C. Gazes: physician, teacher, scholar. Clin Cardiol. 2003 Mar; 26(3):158-9. PMID: 12685625.
      View in: PubMed
    258. King MK, Coker ML, Goldberg A, McElmurray JH, Gunasinghe HR, Mukherjee R, Zile MR, O'Neill TP, Spinale FG. Selective matrix metalloproteinase inhibition with developing heart failure: effects on left ventricular function and structure. Circ Res. 2003 Feb 07; 92(2):177-85. PMID: 12574145.
      View in: PubMed
    259. Mukherjee R, Brinsa TA, Dowdy KB, Scott AA, Baskin JM, Deschamps AM, Lowry AS, Escobar GP, Lucas DG, Yarbrough WM, Zile MR, Spinale FG. Myocardial infarct expansion and matrix metalloproteinase inhibition. Circulation. 2003 Feb 04; 107(4):618-25. PMID: 12566376.
      View in: PubMed
    260. Baicu CF, Stroud JD, Livesay VA, Hapke E, Holder J, Spinale FG, Zile MR. Changes in extracellular collagen matrix alter myocardial systolic performance. Am J Physiol Heart Circ Physiol. 2003 Jan; 284(1):H122-32. PMID: 12485818.
      View in: PubMed
    261. Zile MR. Structural components of cardiomyocyte remodeling: summation. J Card Fail. 2002 Dec; 8(6 Suppl):S311-3. PMID: 12555137.
      View in: PubMed
    262. Creemers EE, Davis JN, Parkhurst AM, Leenders P, Dowdy KB, Hapke E, Hauet AM, Escobar PG, Cleutjens JP, Smits JF, Daemen MJ, Zile MR, Spinale FG. Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice. Am J Physiol Heart Circ Physiol. 2003 Jan; 284(1):H364-71. PMID: 12388239.
      View in: PubMed
    263. Harris TS, Baicu CF, Conrad CH, Koide M, Buckley JM, Barnes M, Cooper G, Zile MR. Constitutive properties of hypertrophied myocardium: cellular contribution to changes in myocardial stiffness. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H2173-82. PMID: 12003826.
      View in: PubMed
    264. Stroud JD, Baicu CF, Barnes MA, Spinale FG, Zile MR. Viscoelastic properties of pressure overload hypertrophied myocardium: effect of serine protease treatment. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H2324-35. PMID: 12003843.
      View in: PubMed
    265. Yun KL, Sintek CF, Miller DC, Pfeffer TA, Kochamba GS, Khonsari S, Zile MR. Randomized trial comparing partial versus complete chordal-sparing mitral valve replacement: effects on left ventricular volume and function. J Thorac Cardiovasc Surg. 2002 Apr; 123(4):707-14. PMID: 11986599.
      View in: PubMed
    266. Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure: Part II: causal mechanisms and treatment. Circulation. 2002 Mar 26; 105(12):1503-8. PMID: 11914262.
      View in: PubMed
    267. Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function. Circulation. 2002 Mar 19; 105(11):1387-93. PMID: 11901053.
      View in: PubMed
    268. Müller JG, Isomatsu Y, Koushik SV, O'Quinn M, Xu L, Kappler CS, Hapke E, Zile MR, Conway SJ, Menick DR. Cardiac-specific expression and hypertrophic upregulation of the feline Na(+)-Ca(2+) exchanger gene H1-promoter in a transgenic mouse model. Circ Res. 2002 Feb 08; 90(2):158-64. PMID: 11834708.
      View in: PubMed
    269. Zile MR, Gaasch WH, Carroll JD, Feldman MD, Aurigemma GP, Schaer GL, Ghali JK, Liebson PR. Heart failure with a normal ejection fraction: is measurement of diastolic function necessary to make the diagnosis of diastolic heart failure? Circulation. 2001 Aug 14; 104(7):779-82. PMID: 11502702.
      View in: PubMed
    270. Walker CA, Ergul A, Grubbs A, Zile MR, Zellner JL, Crumbley AJ, Spinale FG. beta-Adrenergic and endothelin receptor interaction in dilated human cardiomyopathic myocardium. J Card Fail. 2001 Jun; 7(2):129-37. PMID: 11420764.
      View in: PubMed
    271. Zile MR, Green GR, Schuyler GT, Aurigemma GP, Miller DC, Cooper G. Cardiocyte cytoskeleton in patients with left ventricular pressure overload hypertrophy. J Am Coll Cardiol. 2001 Mar 15; 37(4):1080-4. PMID: 11263612.
      View in: PubMed
    272. Ishibashi Y, Rembert JC, Carabello BA, Nemoto S, Hamawaki M, Zile MR, Greenfield JC, Cooper G. Normal myocardial function in severe right ventricular volume overload hypertrophy. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H11-6. PMID: 11123212.
      View in: PubMed
    273. Gramling-Babb PM, Zile MR, Reeves ST. Preliminary report on high thoracic epidural analgesia: relationship between its therapeutic effects and myocardial blood flow as assessed by stress thallium distribution. J Cardiothorac Vasc Anesth. 2000 Dec; 14(6):657-61. PMID: 11139104.
      View in: PubMed
    274. Laser M, Willey CD, Jiang W, Cooper G, Menick DR, Zile MR, Kuppuswamy D. Integrin activation and focal complex formation in cardiac hypertrophy. J Biol Chem. 2000 Nov 10; 275(45):35624-30. PMID: 10958798.
      View in: PubMed
    275. Zile MR, Nappi J. Diastolic Heart Failure. Curr Treat Options Cardiovasc Med. 2000 Oct; 2(5):439-450. PMID: 11096548.
      View in: PubMed
    276. Koide M, Hamawaki M, Narishige T, Sato H, Nemoto S, DeFreyte G, Zile MR, Cooper G IV, Carabello BA. Microtubule depolymerization normalizes in vivo myocardial contractile function in dogs with pressure-overload left ventricular hypertrophy. Circulation. 2000 Aug 29; 102(9):1045-52. PMID: 10961971.
      View in: PubMed
    277. Ghatpande S, Ghatpande A, Zile M, Evans T. Anterior endoderm is sufficient to rescue foregut apoptosis and heart tube morphogenesis in an embryo lacking retinoic acid. Dev Biol. 2000 Mar 01; 219(1):59-70. PMID: 10677255.
      View in: PubMed
    278. Maden M, Graham A, Zile M, Gale E. Abnormalities of somite development in the absence of retinoic acid. Int J Dev Biol. 2000; 44(1):151-9. PMID: 10761860.
      View in: PubMed
    279. Zile MR, Simsic JM. Diastolic heart failure: diagnosis and treatment. Clin Cornerstone. 2000; 3(2):13-24. PMID: 11205721.
      View in: PubMed
    280. Roten L, Nemoto S, Simsic J, Coker ML, Rao V, Baicu S, Defreyte G, Soloway PJ, Zile MR, Spinale FG. Effects of gene deletion of the tissue inhibitor of the matrix metalloproteinase-type 1 (TIMP-1) on left ventricular geometry and function in mice. J Mol Cell Cardiol. 2000 Jan; 32(1):109-20. PMID: 10652195.
      View in: PubMed
    281. Yun KL, Sintek CF, Miller DC, Schuyler GT, Fletcher AD, Pfeffer TA, Kochamba GS, Khonsari S, Zile MR. Randomized trial of partial versus complete chordal preservation methods of mitral valve replacement: A preliminary report. Circulation. 1999 Nov 09; 100(19 Suppl):II90-4. PMID: 10567284.
      View in: PubMed
    282. McElmurray JH, Mukherjee R, New RB, Sampson AC, King MK, Hendrick JW, Goldberg A, Peterson TJ, Hallak H, Zile MR, Spinale FG. Angiotensin-converting enzyme and matrix metalloproteinase inhibition with developing heart failure: comparative effects on left ventricular function and geometry. J Pharmacol Exp Ther. 1999 Nov; 291(2):799-811. PMID: 10525103.
      View in: PubMed
    283. Spinale FG, Coker ML, Krombach SR, Mukherjee R, Hallak H, Houck WV, Clair MJ, Kribbs SB, Johnson LL, Peterson JT, Zile MR. Matrix metalloproteinase inhibition during the development of congestive heart failure : effects on left ventricular dimensions and function. Circ Res. 1999 Aug 20; 85(4):364-76. PMID: 10455065.
      View in: PubMed
    284. Nagai T, Laser M, Baicu CF, Zile MR, Cooper G, Kuppuswamy D. Beta3-integrin-mediated focal adhesion complex formation: adult cardiocytes embedded in three-dimensional polymer matrices. Am J Cardiol. 1999 Jun 17; 83(12A):38H-43H. PMID: 10750585.
      View in: PubMed
    285. Stratford T, Logan C, Zile M, Maden M. Abnormal anteroposterior and dorsoventral patterning of the limb bud in the absence of retinoids. Mech Dev. 1999 Mar; 81(1-2):115-25. PMID: 10330489.
      View in: PubMed
    286. Kostetskii I, Jiang Y, Kostetskaia E, Yuan S, Evans T, Zile M. Retinoid signaling required for normal heart development regulates GATA-4 in a pathway distinct from cardiomyocyte differentiation. Dev Biol. 1999 Feb 15; 206(2):206-18. PMID: 9986733.
      View in: PubMed
    287. Koide M, Carabello BA, Conrad CC, Buckley JM, DeFreyte G, Barnes M, Tomanek RJ, Wei CC, Dell'Italia LJ, Cooper G, Zile MR. Hypertrophic response to hemodynamic overload: role of load vs. renin-angiotensin system activation. Am J Physiol. 1999 Feb; 276(2 Pt 2):H350-8. PMID: 9950833.
      View in: PubMed
    288. Zile MR, Koide M, Sato H, Ishiguro Y, Conrad CH, Buckley JM, Morgan JP, Cooper G. Role of microtubules in the contractile dysfunction of hypertrophied myocardium. J Am Coll Cardiol. 1999 Jan; 33(1):250-60. PMID: 9935038.
      View in: PubMed
    289. Kostetskii I, Yuan SY, Kostetskaia E, Linask KK, Blanchet S, Seleiro E, Michaille JJ, Brickell P, Zile M. Initial retinoid requirement for early avian development coincides with retinoid receptor coexpression in the precardiac fields and induction of normal cardiovascular development. Dev Dyn. 1998 Oct; 213(2):188-98. PMID: 9786419.
      View in: PubMed
    290. Zile MR, Richardson K, Cowles MK, Buckley JM, Koide M, Cowles BA, Gharpuray V, Cooper G. Constitutive properties of adult mammalian cardiac muscle cells. Circulation. 1998 Aug 11; 98(6):567-79. PMID: 9714115.
      View in: PubMed
    291. Matsuo T, Carabello BA, Nagatomo Y, Koide M, Hamawaki M, Zile MR, McDermott PJ. Mechanisms of cardiac hypertrophy in canine volume overload. Am J Physiol. 1998 Jul; 275(1 Pt 2):H65-74. PMID: 9688897.
      View in: PubMed
    292. Zile MR, Cowles MK, Buckley JM, Richardson K, Cowles BA, Baicu CF, Cooper G IV, Gharpuray V. Gel stretch method: a new method to measure constitutive properties of cardiac muscle cells. Am J Physiol. 1998 Jun; 274(6 Pt 2):H2188-202. PMID: 9841544.
      View in: PubMed
    293. Tagawa H, Koide M, Sato H, Zile MR, Carabello BA, Cooper G. Cytoskeletal role in the transition from compensated to decompensated hypertrophy during adult canine left ventricular pressure overloading. Circ Res. 1998 Apr 20; 82(7):751-61. PMID: 9562434.
      View in: PubMed
    294. Hamawaki M, Coffman TM, Lashus A, Koide M, Zile MR, Oliverio MI, DeFreyte G, Cooper G, Carabello BA. Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors. Am J Physiol. 1998 03; 274(3):H868-73. PMID: 9530198.
      View in: PubMed
    295. Goldfine H, Aurigemma GP, Zile MR, Gaasch WH. Left ventricular length-force-shortening relations before and after surgical correction of chronic mitral regurgitation. J Am Coll Cardiol. 1998 Jan; 31(1):180-5. PMID: 9426038.
      View in: PubMed
    296. Gramling-Babb P, Miller MJ, Reeves ST, Roy RC, Zile MR. Treatment of medically and surgically refractory angina pectoris with high thoracic epidural analgesia: initial clinical experience. Am Heart J. 1997 Jun; 133(6):648-55. PMID: 9200392.
      View in: PubMed
    297. Koide M, Nagatsu M, Zile MR, Hamawaki M, Swindle MM, Keech G, DeFreyte G, Tagawa H, Cooper G, Carabello BA. Premorbid determinants of left ventricular dysfunction in a novel model of gradually induced pressure overload in the adult canine. Circulation. 1997 Mar 18; 95(6):1601-10. PMID: 9118531.
      View in: PubMed
    298. Tagawa H, Wang N, Narishige T, Ingber DE, Zile MR, Cooper G. Cytoskeletal mechanics in pressure-overload cardiac hypertrophy. Circ Res. 1997 Feb; 80(2):281-9. PMID: 9012750.
      View in: PubMed
    299. Kato S, Koide M, Cooper G, Zile MR. Effects of pressure- or volume-overload hypertrophy on passive stiffness in isolated adult cardiac muscle cells. Am J Physiol. 1996 Dec; 271(6 Pt 2):H2575-83. PMID: 8997318.
      View in: PubMed
    300. Wada H, Zile MR, Ivester CT, Cooper G, McDermott PJ. Comparative effects of contraction and angiotensin II on growth of adult feline cardiocytes in primary culture. Am J Physiol. 1996 Jul; 271(1 Pt 2):H29-37. PMID: 8760154.
      View in: PubMed
    301. Tanaka R, Barnes MA, Cooper G, Zile MR. Effects of anisosmotic stress on cardiac muscle cell length, diameter, area, and sarcomere length. Am J Physiol. 1996 Apr; 270(4 Pt 2):H1414-22. PMID: 8967384.
      View in: PubMed
    302. Kato S, Spinale FG, Tanaka R, Johnson W, Cooper G, Zile MR. Inhibition of collagen cross-linking: effects on fibrillar collagen and ventricular diastolic function. Am J Physiol. 1995 Sep; 269(3 Pt 2):H863-8. PMID: 7573529.
      View in: PubMed
    303. Kato S, Ivester CT, Cooper G, Zile MR, McDermott PJ. Growth effects of electrically stimulated contraction on adult feline cardiocytes in primary culture. Am J Physiol. 1995 Jun; 268(6 Pt 2):H2495-504. PMID: 7611500.
      View in: PubMed
    304. Zile MR, Mukherjee R, Clayton C, Kato S, Spinale FG. Effects of chronic supraventricular pacing tachycardia on relaxation rate in isolated cardiac muscle cells. Am J Physiol. 1995 May; 268(5 Pt 2):H2104-13. PMID: 7771561.
      View in: PubMed
    305. Rozich JD, Barnes MA, Schmid PG, Zile MR, McDermott PJ, Cooper G. Load effects on gene expression during cardiac hypertrophy. J Mol Cell Cardiol. 1995 Jan; 27(1):485-99. PMID: 7760368.
      View in: PubMed
    306. Walker JD, Crawford FA, Mukherjee R, Zile MR, Spinale FG. Direct effects of acute administration of 3, 5, 3' triiodo-L-thyronine on myocyte function. Ann Thorac Surg. 1994 Sep; 58(3):851-6. PMID: 7944715.
      View in: PubMed
    307. Spinale FG, Tempel GE, Mukherjee R, Eble DM, Brown R, Vacchiano CA, Zile MR. Cellular and molecular alterations in the beta adrenergic system with cardiomyopathy induced by tachycardia. Cardiovasc Res. 1994 Aug; 28(8):1243-50. PMID: 7954628.
      View in: PubMed
    308. Hird RB, Crawford FA, Mukherjee R, Zile MR, Spinale FG. Effects of protamine on myocyte contractile function and beta-adrenergic responsiveness. Ann Thorac Surg. 1994 May; 57(5):1066-74; discussion 1074-5. PMID: 8179366.
      View in: PubMed
    309. Nagatsu M, Zile MR, Tsutsui H, Schmid PG, DeFreyte G, Cooper G, Carabello BA. Native beta-adrenergic support for left ventricular dysfunction in experimental mitral regurgitation normalizes indexes of pump and contractile function. Circulation. 1994 Feb; 89(2):818-26. PMID: 8313571.
      View in: PubMed
    310. Nagatsu M, Ishihara K, Zile MR, Tsutsui H, Tagawa H, DeFreyte G, Tanaka R, Cooper G, Carabello BA. The effects of complete versus incomplete mitral valve repair in experimental mitral regurgitation. J Thorac Cardiovasc Surg. 1994 Feb; 107(2):416-23. PMID: 8302060.
      View in: PubMed
    311. Assey ME, Zile MR, Usher BW, Karavan MP, Carabello BA. Effect of catheter positioning on the variability of measured gradient in aortic stenosis. Cathet Cardiovasc Diagn. 1993 Dec; 30(4):287-92. PMID: 8287452.
      View in: PubMed
    312. Spinale FG, Ishihra K, Zile M, DeFryte G, Crawford FA, Carabello BA. Structural basis for changes in left ventricular function and geometry because of chronic mitral regurgitation and after correction of volume overload. J Thorac Cardiovasc Surg. 1993 Dec; 106(6):1147-57. PMID: 8246553.
      View in: PubMed
    313. Tanaka R, Fulbright BM, Mukherjee R, Burchell SA, Crawford FA, Zile MR, Spinale FG. The cellular basis for the blunted response to beta-adrenergic stimulation in supraventricular tachycardia-induced cardiomyopathy. J Mol Cell Cardiol. 1993 Oct; 25(10):1215-33. PMID: 8263955.
      View in: PubMed
    314. Tsutsui H, Urabe Y, Mann DL, Tagawa H, Carabello BA, Cooper G, Zile MR. Effects of chronic mitral regurgitation on diastolic function in isolated cardiocytes. Circ Res. 1993 May; 72(5):1110-23. PMID: 8477523.
      View in: PubMed
    315. Zile MR, Tomita M, Ishihara K, Nakano K, Lindroth J, Spinale F, Swindle M, Carabello BA. Changes in diastolic function during development and correction of chronic LV volume overload produced by mitral regurgitation. Circulation. 1993 Apr; 87(4):1378-88. PMID: 8462159.
      View in: PubMed
    316. Spinale FG, Mukherjee R, Fulbright BM, Hu J, Crawford FA, Zile MR. Contractile properties of isolated porcine ventricular myocytes. Cardiovasc Res. 1993 Feb; 27(2):304-11. PMID: 8472283.
      View in: PubMed
    317. Rozich JD, Carabello BA, Usher BW, Kratz JM, Bell AE, Zile MR. Mitral valve replacement with and without chordal preservation in patients with chronic mitral regurgitation. Mechanisms for differences in postoperative ejection performance. Circulation. 1992 Dec; 86(6):1718-26. PMID: 1451243.
      View in: PubMed
    318. Ishihara K, Zile MR, Nagatsu M, Nakano K, Tomita M, Kanazawa S, Clamp L, DeFreyte G, Carabello BA. Coronary blood flow after the regression of pressure-overload left ventricular hypertrophy. Circ Res. 1992 Dec; 71(6):1472-81. PMID: 1423939.
      View in: PubMed
    319. Tanaka R, Spinale FG, Crawford FA, Zile MR. Effect of chronic supraventricular tachycardia on left ventricular function and structure in newborn pigs. J Am Coll Cardiol. 1992 Dec; 20(7):1650-60. PMID: 1452940.
      View in: PubMed
    320. Cannon JD, Zile MR, Crawford FA, Carabello BA. Aortic valve resistance as an adjunct to the Gorlin formula in assessing the severity of aortic stenosis in symptomatic patients. J Am Coll Cardiol. 1992 Dec; 20(7):1517-23. PMID: 1452925.
      View in: PubMed
    321. Ishihara K, Zile MR, Kanazawa S, Tsutsui H, Urabe Y, DeFreyte G, Carabello BA. Left ventricular mechanics and myocyte function after correction of experimental chronic mitral regurgitation by combined mitral valve replacement and preservation of the native mitral valve apparatus. Circulation. 1992 Nov; 86(5 Suppl):II16-25. PMID: 1423995.
      View in: PubMed
    322. Burchell SA, Spinale FG, Crawford FA, Tanaka R, Zile MR. Effects of chronic tachycardia-induced cardiomyopathy on the beta-adrenergic receptor system. J Thorac Cardiovasc Surg. 1992 Oct; 104(4):1006-12. PMID: 1328769.
      View in: PubMed
    323. Carabello BA, Zile MR, Tanaka R, Cooper G. Left ventricular hypertrophy due to volume overload versus pressure overload. Am J Physiol. 1992 Oct; 263(4 Pt 2):H1137-44. PMID: 1415762.
      View in: PubMed
    324. Zile MR, Tanaka R, Lindroth JR, Spinale F, Carabello BA, Mirsky I. Left ventricular volume determined echocardiographically by assuming a constant left ventricular epicardial long-axis/short-axis dimension ratio throughout the cardiac cycle. J Am Coll Cardiol. 1992 Oct; 20(4):986-93. PMID: 1388183.
      View in: PubMed
    325. Spinale FG, Fulbright BM, Mukherjee R, Tanaka R, Hu J, Crawford FA, Zile MR. Relation between ventricular and myocyte function with tachycardia-induced cardiomyopathy. Circ Res. 1992 Jul; 71(1):174-87. PMID: 1606661.
      View in: PubMed
    326. Ishihara K, Zile MR, Tomita M, Tanaka R, Kanazawa S, Carabello BA. Left ventricular hypertrophy in a canine model of reversible pressure overload. Cardiovasc Res. 1992 Jun; 26(6):580-5. PMID: 1451137.
      View in: PubMed
    327. Gwinn N, Leman R, Kratz J, White JK, Zile MR, Gillette P. Chronotropic incompetence: a common and progressive finding in pacemaker patients. Am Heart J. 1992 May; 123(5):1216-9. PMID: 1575136.
      View in: PubMed
    328. Spinale FG, Mukherjee R, Tanaka R, Zile MR. The effects of valvular regurgitation on thermodilution ejection fraction measurements. Chest. 1992 Mar; 101(3):723-31. PMID: 1541138.
      View in: PubMed
    329. Spinale FG, Clayton C, Tanaka R, Fulbright BM, Mukherjee R, Schulte BA, Crawford FA, Zile MR. Myocardial Na+,K(+)-ATPase in tachycardia induced cardiomyopathy. J Mol Cell Cardiol. 1992 Mar; 24(3):277-94. PMID: 1320703.
      View in: PubMed
    330. Spinale FG, Tanaka R, Crawford FA, Zile MR. Changes in myocardial blood flow during development of and recovery from tachycardia-induced cardiomyopathy. Circulation. 1992 Feb; 85(2):717-29. PMID: 1735164.
      View in: PubMed
    331. Spinale FG, Grine RC, Tempel GE, Crawford FA, Zile MR. Alterations in the myocardial capillary vasculature accompany tachycardia-induced cardiomyopathy. Basic Res Cardiol. 1992 Jan-Feb; 87(1):65-79. PMID: 1567354.
      View in: PubMed
    332. Zile MR, Tomita M, Nakano K, Mirsky I, Usher B, Lindroth J, Carabello BA. Effects of left ventricular volume overload produced by mitral regurgitation on diastolic function. Am J Physiol. 1991 Nov; 261(5 Pt 2):H1471-80. PMID: 1951734.
      View in: PubMed
    333. Spinale FG, Zellner JL, Tomita M, Crawford FA, Zile MR. Relation between ventricular and myocyte remodeling with the development and regression of supraventricular tachycardia-induced cardiomyopathy. Circ Res. 1991 Oct; 69(4):1058-67. PMID: 1934334.
      View in: PubMed
    334. Zile MR, Gaasch WH. Load-dependent left ventricular relaxation in conscious dogs. Am J Physiol. 1991 Sep; 261(3 Pt 2):H691-9. PMID: 1887917.
      View in: PubMed
    335. Izzi G, Zile MR, Gaasch WH. Myocardial oxygen consumption and the left ventricular pressure-volume area in normal and hypertrophic canine hearts. Circulation. 1991 Sep; 84(3):1384-92. PMID: 1832096.
      View in: PubMed
    336. Spinale FG, Tomita M, Zellner JL, Cook JC, Crawford FA, Zile MR. Collagen remodeling and changes in LV function during development and recovery from supraventricular tachycardia. Am J Physiol. 1991 Aug; 261(2 Pt 2):H308-18. PMID: 1877659.
      View in: PubMed
    337. Gaasch WH, Zile MR. Left ventricular function after surgical correction of chronic mitral regurgitation. Eur Heart J. 1991 Jul; 12 Suppl B:48-51. PMID: 1936024.
      View in: PubMed
    338. Spinale FG, Zellner JL, Tomita M, Tempel GE, Crawford FA, Zile MR. Tachycardia-induced cardiomyopathy: effects on blood flow and capillary structure. Am J Physiol. 1991 Jul; 261(1 Pt 2):H140-8. PMID: 1858914.
      View in: PubMed
    339. Nakano K, Swindle MM, Spinale F, Ishihara K, Kanazawa S, Smith A, Biederman RW, Clamp L, Hamada Y, Zile MR, et al. Depressed contractile function due to canine mitral regurgitation improves after correction of the volume overload. J Clin Invest. 1991 Jun; 87(6):2077-86. PMID: 1828252.
      View in: PubMed
    340. Zile MR. Chronic aortic and mitral regurgitation. Choosing the optimal time for surgical correction. Cardiol Clin. 1991 May; 9(2):239-53. PMID: 2054815.
      View in: PubMed
    341. Rozich JD, Smith B, Thomas JD, Zile MR, Kaiser J, Mann DL. Dialysis-induced alterations in left ventricular filling: mechanisms and clinical significance. Am J Kidney Dis. 1991 Mar; 17(3):277-85. PMID: 1996569.
      View in: PubMed
    342. Zile MR, Izzi G, Gaasch WH. Left ventricular diastolic dysfunction limits use of maximum systolic elastance as an index of contractile function. Circulation. 1991 Feb; 83(2):674-80. PMID: 1825039.
      View in: PubMed
    343. Tomita M, Spinale FG, Crawford FA, Zile MR. Changes in left ventricular volume, mass, and function during the development and regression of supraventricular tachycardia-induced cardiomyopathy. Disparity between recovery of systolic versus diastolic function. Circulation. 1991 Feb; 83(2):635-44. PMID: 1991381.
      View in: PubMed
    344. Swindle MM, Spinale FG, Smith AC, Schumann RE, Green CT, Nakano K, Kanasawa S, Ishihara K, Zile MR, Carabello BA. Anesthetic and postoperative protocols for a canine model of reversible left ventricular volume overload. J Invest Surg. 1991; 4(3):339-46. PMID: 1832953.
      View in: PubMed
    345. Gaasch WH, Zile MR, Hoshino PK, Weinberg EO, Rhodes DR, Apstein CS. Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload hypertrophy. Circulation. 1990 May; 81(5):1644-53. PMID: 2139593.
      View in: PubMed
    346. Zile MR, Gaasch WH. Mechanical loads and the isovolumic and filling indices of left ventricular relaxation. Prog Cardiovasc Dis. 1990 Mar-Apr; 32(5):333-46. PMID: 2179994.
      View in: PubMed
    347. Zile MR, Conrad CH, Gaasch WH, Robinson KG, Bing OH. Preload does not affect relaxation rate in normal, hypoxic, or hypertrophic myocardium. Am J Physiol. 1990 Jan; 258(1 Pt 2):H191-7. PMID: 2137298.
      View in: PubMed
    348. Zile MR, Blaustein AS, Gaasch WH. The effect of acute alterations in left ventricular afterload and beta-adrenergic tone on indices of early diastolic filling rate. Circ Res. 1989 Aug; 65(2):406-16. PMID: 2546696.
      View in: PubMed
    349. Gaasch WH, Zile MR, Hoshino PK, Apstein CS, Blaustein AS. Stress-shortening relations and myocardial blood flow in compensated and failing canine hearts with pressure-overload hypertrophy. Circulation. 1989 Apr; 79(4):872-83. PMID: 2522357.
      View in: PubMed
    350. Zile MR, Neill WA, Gaasch WH, Oxendine J, Apstein CS, Weinberg E, Bing OH. Distribution of a neutral cardioplegic vehicle during the development of ischemic myocardial contracture. J Mol Cell Cardiol. 1987 Oct; 19(10):977-89. PMID: 2449532.
      View in: PubMed
    351. Zile MR, Blaustein AS, Shimizu G, Gaasch WH. Right ventricular pacing reduces the rate of left ventricular relaxation and filling. J Am Coll Cardiol. 1987 Sep; 10(3):702-9. PMID: 3624674.
      View in: PubMed
    352. Zile MR, Gaasch WH, Wiegner AW, Robinson KG, Bing OH. Mechanical determinants of maximum isotonic lengthening rate in rat left ventricular myocardium. Circ Res. 1987 Jun; 60(6):815-23. PMID: 3594754.
      View in: PubMed
    353. Konstam MA, Weiland DS, Conlon TP, Martin TT, Cohen SR, Eichhorn EJ, Isner JM, Zile MR, Salem DN. Hemodynamic correlates of left ventricular versus right ventricular radionuclide volumetric responses to vasodilator therapy in congestive heart failure secondary to ischemic or dilated cardiomyopathy. Am J Cardiol. 1987 May 01; 59(12):1131-7. PMID: 3578055.
      View in: PubMed
    354. Weiland DS, Konstam MA, Salem DN, Martin TT, Cohen SR, Zile MR, Das D. Contribution of reduced mitral regurgitant volume to vasodilator effect in severe left ventricular failure secondary to coronary artery disease or idiopathic dilated cardiomyopathy. Am J Cardiol. 1986 Nov 01; 58(10):1046-50. PMID: 3776843.
      View in: PubMed
    355. Zile MR, Gaasch WH, Levine HJ. Left ventricular stress-dimension-shortening relations before and after correction of chronic aortic and mitral regurgitation. Am J Cardiol. 1985 Jul 01; 56(1):99-105. PMID: 3160230.
      View in: PubMed
    356. Konstam MA, Cohen SR, Salem DN, Conlon TP, Isner JM, Das D, Zile MR, Levine HJ, Kahn PC. Comparison of left and right ventricular end-systolic pressure-volume relations in congestive heart failure. J Am Coll Cardiol. 1985 Jun; 5(6):1326-34. PMID: 3923077.
      View in: PubMed
    357. Shimizu G, Zile MR, Blaustein AS, Gaasch WH. Left ventricular chamber filling and midwall fiber lengthening in patients with left ventricular hypertrophy: overestimation of fiber velocities by conventional midwall measurements. Circulation. 1985 Feb; 71(2):266-72. PMID: 3155498.
      View in: PubMed
    358. Gaasch WH, Zile MR. Evaluation of myocardial function in cardiomyopathic states. Prog Cardiovasc Dis. 1984 Sep-Oct; 27(2):115-32. PMID: 6382437.
      View in: PubMed
    359. Konstam MA, Salem DN, Isner JM, Zile MR, Kahn PC, Bonin JD, Cohen SR, Levine HJ. Vasodilator effect on right ventricular function in congestive heart failure and pulmonary hypertension: end-systolic pressure--volume relation. Am J Cardiol. 1984 Jul 01; 54(1):132-6. PMID: 6430055.
      View in: PubMed
    360. Zile MR, Gaasch WH, Carroll JD, Levine HJ. Chronic mitral regurgitation: predictive value of preoperative echocardiographic indexes of left ventricular function and wall stress. J Am Coll Cardiol. 1984 Feb; 3(2 Pt 1):235-42. PMID: 6693615.
      View in: PubMed
    361. Carroll JD, Gaasch WH, Zile MR, Levine HJ. Serial changes in left ventricular function after correction of chronic aortic regurgitation. Dependence on early changes in preload and subsequent regression of hypertrophy. Am J Cardiol. 1983 Feb; 51(3):476-82. PMID: 6218744.
      View in: PubMed
    362. Coffey RL, Zile MR, Luskin AT. Immunologic tests of value in diagnosis. 1. Acute phase reactants and autoantibodies. Postgrad Med. 1981 Aug; 70(2):163-78. PMID: 7019872.
      View in: PubMed
    363. Coffey RL, Zile MR, Luskin AT. Immunologic tests of value in diagnosis. 2. Complement. Postgrad Med. 1981 Aug; 70(2):183-8. PMID: 7019873.
      View in: PubMed
    364. Ito YL, Zile M, Ahrens H, DeLuca HF. Liquid-gel partition chromatography of vitamin A compounds; formation of retinoic acid from retinyl acetate in vivo. J Lipid Res. 1974 Sep; 15(5):517-24. PMID: 4414497.
      View in: PubMed
    Zile's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _