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Michael R. Zile

TitleEndowed Chair, Charles Ezra Daniel for Cardiology
InstitutionMedical University of South Carolina
DepartmentCardiology
AddressP.O. Box MSC 592
BM 323
Thurmond Gazes - 30 Courtenay Drive
Phone843-792-6866
Fax843-876-4809
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    Collapse Overview 
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    Heart, Cardiovascular

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chandra A, Lewis EF, Claggett BL, Desai AS, Packer M, Zile MR, Swedberg K, Rouleau JL, Shi VC, Lefkowitz MP, Katova T, McMurray JJV, Solomon SD. Effects of Sacubitril/Valsartan on Physical and Social Activity Limitations in Patients With Heart Failure: A Secondary Analysis of the PARADIGM-HF Trial. JAMA Cardiol. 2018 Apr 04. PMID: 29617523.
      View in: PubMed
    2. Vardeny O, Claggett B, Kachadourian J, Pearson SM, Desai AS, Packer M, Rouleau J, Zile MR, Swedberg K, Lefkowitz M, Shi V, McMurray JJV, Solomon SD. Incidence, Predictors, and Outcomes Associated With Hypotensive Episodes Among Heart Failure Patients Receiving Sacubitril/Valsartan or Enalapril: The PARADIGM-HF Trial (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure). Circ Heart Fail. 2018 Apr; 11(4):e004745. PMID: 29643067.
      View in: PubMed
    3. McDonald LT, Zile MR, Zhang Y, Van Laer AO, Baicu CF, Stroud RE, Jones JA, LaRue AC, Bradshaw AD. Increased Macrophage-derived SPARC Precedes Collagen Deposition in Myocardial Fibrosis. Am J Physiol Heart Circ Physiol. 2018 Mar 09. PMID: 29522370.
      View in: PubMed
    4. Vaduganathan M, Claggett B, Packer M, McMurray JJV, Rouleau JL, Zile MR, Swedberg K, Solomon SD. Natriuretic Peptides as Biomarkers of Treatment Response in Clinical Trials of Heart Failure. JACC Heart Fail. 2018 Mar 04. PMID: 29501807.
      View in: PubMed
    5. Mogensen UM, Gong J, Jhund PS, Shen L, Køber L, Desai AS, Lefkowitz MP, Packer M, Rouleau JL, Solomon SD, Claggett BL, Swedberg K, Zile MR, Mueller-Velten G, McMurray JJV. Effect of sacubitril/valsartan on recurrent events in the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF). Eur J Heart Fail. 2018 Apr; 20(4):760-768. PMID: 29431251.
      View in: PubMed
    6. Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M. Cardiac macrophages promote diastolic dysfunction. J Exp Med. 2018 Feb 05; 215(2):423-440. PMID: 29339450.
      View in: PubMed
    7. Mogensen UM, Jhund PS, Abraham WT, Desai AS, Dickstein K, Packer M, Rouleau JL, Solomon SD, Swedberg K, Zile MR, Køber L, McMurray JJV. Type of Atrial Fibrillation and Outcomes in Patients With Heart Failure and Reduced Ejection Fraction. J Am Coll Cardiol. 2017 Nov 14; 70(20):2490-2500. PMID: 29145948.
      View in: PubMed
    8. LeWinter MM, Taatjes D, Ashikaga T, Palmer B, Bishop N, VanBuren P, Bell S, Donaldson C, Meyer M, Margulies KB, Redfield M, Bull DA, Zile M. Abundance, localization, and functional correlates of the advanced glycation end-product carboxymethyl lysine in human myocardium. Physiol Rep. 2017 Nov; 5(20). PMID: 29066596.
      View in: PubMed
    9. Shen L, Ramires F, Martinez F, Bodanese LC, Echeverría LE, Gómez EA, Abraham WT, Dickstein K, Køber L, Packer M, Rouleau JL, Solomon SD, Swedberg K, Zile MR, Jhund PS, Gimpelewicz CR, McMurray JJV. Contemporary Characteristics and Outcomes in Chagasic Heart Failure Compared With Other Nonischemic and Ischemic Cardiomyopathy. Circ Heart Fail. 2017 Nov; 10(11). PMID: 29141857.
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    10. Fitzgibbon WR, Dang Y, Bunni MA, Baicu CF, Zile MR, Mullick AE, Saigusa T. Attenuation of accelerated renal cystogenesis in Pkd1 mice by renin-angiotensin system blockade. Am J Physiol Renal Physiol. 2018 02 01; 314(2):F210-F218. PMID: 29021226.
      View in: PubMed
    11. Lam PH, Dooley DJ, Deedwania P, Singh SN, Bhatt DL, Morgan CJ, Butler J, Mohammed SF, Wu WC, Panjrath G, Zile MR, White M, Arundel C, Love TE, Blackman MR, Allman RM, Aronow WS, Anker SD, Fonarow GC, Ahmed A. Heart Rate and Outcomes in Hospitalized Patients With Heart Failure With Preserved Ejection Fraction. J Am Coll Cardiol. 2017 Oct 10; 70(15):1861-1871. PMID: 28982499.
      View in: PubMed
    12. Kristensen SL, Jhund PS, Mogensen UM, Rørth R, Abraham WT, Desai A, Dickstein K, Rouleau JL, Zile MR, Swedberg K, Packer M, Solomon SD, Køber L, McMurray JJV. Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide Levels in Heart Failure Patients With and Without Atrial Fibrillation. Circ Heart Fail. 2017 Oct; 10(10). PMID: 29018174.
      View in: PubMed
    13. Fitzgibbons TP, Edwards YJK, Shaw P, Iskandar A, Ahmed M, Bote J, Shah T, Sinha S, Gerszten RE, Keaney JF, Zile MR, Aurigemma GP. Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy. Front Cardiovasc Med. 2017; 4:49. PMID: 28824923.
      View in: PubMed
    14. Lewis EF, Claggett BL, McMurray JJV, Packer M, Lefkowitz MP, Rouleau JL, Liu J, Shi VC, Zile MR, Desai AS, Solomon SD, Swedberg K. Health-Related Quality of Life Outcomes in PARADIGM-HF. Circ Heart Fail. 2017 Aug; 10(8). PMID: 28784687.
      View in: PubMed
    15. Shen L, Jhund PS, Petrie MC, Claggett BL, Barlera S, Cleland JGF, Dargie HJ, Granger CB, Kjekshus J, Køber L, Latini R, Maggioni AP, Packer M, Pitt B, Solomon SD, Swedberg K, Tavazzi L, Wikstrand J, Zannad F, Zile MR, McMurray JJV. Declining Risk of Sudden Death in Heart Failure. N Engl J Med. 2017 07 06; 377(1):41-51. PMID: 28679089.
      View in: PubMed
    16. Solomon SD, Rizkala AR, Gong J, Wang W, Anand IS, Ge J, Lam CSP, Maggioni AP, Martinez F, Packer M, Pfeffer MA, Pieske B, Redfield MM, Rouleau JL, Van Veldhuisen DJ, Zannad F, Zile MR, Desai AS, Shi VC, Lefkowitz MP, McMurray JJV. Angiotensin Receptor Neprilysin Inhibition in Heart Failure With Preserved Ejection Fraction: Rationale and Design of the PARAGON-HF Trial. JACC Heart Fail. 2017 Jul; 5(7):471-482. PMID: 28662936.
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    17. Minatoguchi S, Kawasaki M, Tanaka R, Yoshizane T, Ono K, Saeki M, Nagaya M, Sato H, Nishigaki K, Noda T, Zile MR, Minatoguchi S. Evaluation of systolic and diastolic properties of hypertensive heart failure using speckle-tracking echocardiography with high volume rates. Heart Vessels. 2017 Oct; 32(10):1202-1213. PMID: 28638961.
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    18. Taylor GJ, Lee DM, Baicu CF, Zile MR. Palliative Care for Advanced Heart Failure in a Department of Veterans Affairs Regional Hospice Program: Patient Selection, a Treatment Protocol, and Clinical Course. J Palliat Med. 2017 Oct; 20(10):1068-1073. PMID: 28530501.
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    19. Böhm M, Young R, Jhund PS, Solomon SD, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Swedberg K, Zile MR, Packer M, McMurray JJV. Systolic blood pressure, cardiovascular outcomes and efficacy and safety of sacubitril/valsartan (LCZ696) in patients with chronic heart failure and reduced ejection fraction: results from PARADIGM-HF. Eur Heart J. 2017 04 14; 38(15):1132-1143. PMID: 28158398.
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    20. Seferovic JP, Claggett B, Seidelmann SB, Seely EW, Packer M, Zile MR, Rouleau JL, Swedberg K, Lefkowitz M, Shi VC, Desai AS, McMurray JJV, Solomon SD. Effect of sacubitril/valsartan versus enalapril on glycaemic control in patients with heart failure and diabetes: a post-hoc analysis from the PARADIGM-HF trial. Lancet Diabetes Endocrinol. 2017 May; 5(5):333-340. PMID: 28330649.
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    21. Mogensen UM, Køber L, Kristensen SL, Jhund PS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Swedberg K, Zile MR, Solomon SD, Packer M, McMurray JJV. The effects of sacubitril/valsartan on coronary outcomes in PARADIGM-HF. Am Heart J. 2017 Jun; 188:35-41. PMID: 28577679.
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    22. Abdul-Rahim AH, Perez AC, MacIsaac RL, Jhund PS, Claggett BL, Carson PE, Komajda M, McKelvie RS, Zile MR, Swedberg K, Yusuf S, Pfeffer MA, Solomon SD, Lip GYH, Lees KR, McMurray JJV. Risk of stroke in chronic heart failure patients with preserved ejection fraction, but without atrial fibrillation: analysis of the CHARM-Preserved and I-Preserve trials. Eur Heart J. 2017 Mar 07; 38(10):742-750. PMID: 28426886.
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    23. Levy WC, Li Y, Reed SD, Zile MR, Shadman R, Dardas T, Whellan DJ, Schulman KA, Ellis SJ, Neilson M, O'Connor CM. Does the Implantable Cardioverter-Defibrillator Benefit Vary With the Estimated Proportional Risk of Sudden Death in Heart Failure Patients? JACC Clin Electrophysiol. 2017 Mar; 3(3):291-298. PMID: 28553663.
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    24. Kristensen SL, Mogensen UM, Jhund PS, Petrie MC, Preiss D, Win S, Køber L, McKelvie RS, Zile MR, Anand IS, Komajda M, Gottdiener JS, Carson PE, McMurray JJ. Clinical and Echocardiographic Characteristics and Cardiovascular Outcomes According to Diabetes Status in Patients With Heart Failure and Preserved Ejection Fraction: A Report From the I-Preserve Trial (Irbesartan in Heart Failure With Preserved Ejection Fraction). Circulation. 2017 Feb 21; 135(8):724-735. PMID: 28052977.
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    25. Zile MR, Bennett TD, El Hajj S, Kueffer FJ, Baicu CF, Abraham WT, Bourge RC, Warner Stevenson L. Intracardiac Pressures Measured Using an Implantable Hemodynamic Monitor: Relationship to Mortality in Patients With Chronic Heart Failure. Circ Heart Fail. 2017 Jan; 10(1). PMID: 28062538.
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    26. Desai AS, Vardeny O, Claggett B, McMurray JJ, Packer M, Swedberg K, Rouleau JL, Zile MR, Lefkowitz M, Shi V, Solomon SD. Reduced Risk of Hyperkalemia During Treatment of Heart Failure With Mineralocorticoid Receptor Antagonists by Use of Sacubitril/Valsartan Compared With Enalapril: A Secondary Analysis of the PARADIGM-HF Trial. JAMA Cardiol. 2017 Jan 01; 2(1):79-85. PMID: 27842179.
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    27. Ferreira JP, Duarte K, Graves TL, Zile MR, Abraham WT, Weaver FA, Lindenfeld J, Zannad F. Natriuretic Peptides, 6-Min Walk Test, and Quality-of-Life Questionnaires as Clinically Meaningful Endpoints in HF Trials. J Am Coll Cardiol. 2016 Dec 20; 68(24):2690-2707. PMID: 27978953.
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    28. Zile MR, Claggett BL, Prescott MF, McMurray JJ, Packer M, Rouleau JL, Swedberg K, Desai AS, Gong J, Shi VC, Solomon SD. Prognostic Implications of Changes in N-Terminal Pro-B-Type Natriuretic Peptide in Patients With Heart Failure. J Am Coll Cardiol. 2016 Dec 06; 68(22):2425-2436. PMID: 27908347.
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    29. Nadruz W, Claggett BL, McMurray JJ, Packer M, Zile MR, Rouleau JL, Desai AS, Swedberg K, Lefkowitz M, Shi VC, Prescott MF, Solomon SD. Impact of Body Mass Index on the Accuracy of N-Terminal Pro-Brain Natriuretic Peptide and Brain Natriuretic Peptide for Predicting Outcomes in Patients With Chronic Heart Failure and Reduced Ejection Fraction: Insights From the PARADIGM-HF Study (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial). Circulation. 2016 Nov 29; 134(22):1785-1787. PMID: 27895026.
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    30. Cannon JA, Shen L, Jhund PS, Kristensen SL, Køber L, Chen F, Gong J, Lefkowitz MP, Rouleau JL, Shi VC, Swedberg K, Zile MR, Solomon SD, Packer M, McMurray JJ. Dementia-related adverse events in PARADIGM-HF and other trials in heart failure with reduced ejection fraction. Eur J Heart Fail. 2017 01; 19(1):129-137. PMID: 27868321.
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    31. Butler J, Hamo CE, Udelson JE, Pitt B, Yancy C, Shah SJ, Desvigne-Nickens P, Bernstein HS, Clark RL, Depre C, Dinh W, Hamer A, Kay-Mugford P, Kramer F, Lefkowitz M, Lewis K, Maya J, Maybaum S, Patel MJ, Pollack PS, Roessig L, Rotman S, Salsali A, Sims JJ, Senni M, Rosano G, Dunnmon P, Stockbridge N, Anker SD, Zile MR, Gheorghiade M. Exploring New Endpoints for Patients With Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2016 Nov; 9(11). PMID: 27756791.
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    32. LeWinter MM, Zile MR. Could Modification of Titin Contribute to an Answer for Heart Failure With Preserved Ejection Fraction? Circulation. 2016 Oct 11; 134(15):1100-1104. PMID: 27630137.
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    33. Okumura N, Jhund PS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Swedberg K, Zile MR, Solomon SD, Packer M, McMurray JJ. Effects of Sacubitril/Valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) According to Background Therapy. Circ Heart Fail. 2016 Sep; 9(9). PMID: 27618854.
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    34. Gaziano TA, Fonarow GC, Claggett B, Chan WW, Deschaseaux-Voinet C, Turner SJ, Rouleau JL, Zile MR, McMurray JJ, Solomon SD. Cost-effectiveness Analysis of Sacubitril/Valsartan vs Enalapril in Patients With Heart Failure and Reduced Ejection Fraction. JAMA Cardiol. 2016 Sep 01; 1(6):666-72. PMID: 27438344.
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    35. Desai AS, Claggett BL, Packer M, Zile MR, Rouleau JL, Swedberg K, Shi V, Lefkowitz M, Starling R, Teerlink J, McMurray JJV, Solomon SD. Influence of Sacubitril/Valsartan (LCZ696) on 30-Day Readmission After Heart Failure Hospitalization. J Am Coll Cardiol. 2016 Jul 19; 68(3):241-248. PMID: 27417000.
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    36. Solomon SD, Claggett B, Packer M, Desai A, Zile MR, Swedberg K, Rouleau J, Shi V, Lefkowitz M, McMurray JJV. Efficacy of Sacubitril/Valsartan Relative to a Prior Decompensation: The PARADIGM-HF Trial. JACC Heart Fail. 2016 Oct; 4(10):816-822. PMID: 27395349.
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    37. Shah SJ, Kitzman DW, Borlaug BA, van Heerebeek L, Zile MR, Kass DA, Paulus WJ. Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap. Circulation. 2016 Jul 05; 134(1):73-90. PMID: 27358439; PMCID: PMC4930115 [Available on 07/05/17].
    38. Brisco MA, Zile MR, Hanberg JS, Wilson FP, Parikh CR, Coca SG, Tang WH, Testani JM. Relevance of Changes in Serum Creatinine During a Heart Failure Trial of Decongestive Strategies: Insights From the DOSE Trial. J Card Fail. 2016 Oct; 22(10):753-60. PMID: 27374839.
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    39. Kristensen SL, Martinez F, Jhund PS, Arango JL, Belohlávek J, Boytsov S, Cabrera W, Gomez E, Hagège AA, Huang J, Kiatchoosakun S, Kim KS, Mendoza I, Senni M, Squire IB, Vinereanu D, Wong RC, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR, Packer M, McMurray JJ. Geographic variations in the PARADIGM-HF heart failure trial. Eur Heart J. 2016 Nov 01; 37(41):3167-3174. PMID: 27354044.
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    40. Gandhi PU, Chow SL, Rector TS, Krum H, Gaggin HK, McMurray JJ, Zile MR, Komajda M, McKelvie RS, Carson PE, Januzzi JL, Anand IS. Prognostic Value of Insulin-Like Growth Factor-Binding Protein 7 in Patients with Heart Failure and Preserved Ejection Fraction. J Card Fail. 2017 Jan; 23(1):20-28. PMID: 27317843.
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    41. Vardeny O, Claggett B, Packer M, Zile MR, Rouleau J, Swedberg K, Teerlink JR, Desai AS, Lefkowitz M, Shi V, McMurray JJ, Solomon SD. Efficacy of sacubitril/valsartan vs. enalapril at lower than target doses in heart failure with reduced ejection fraction: the PARADIGM-HF trial. Eur J Heart Fail. 2016 Oct; 18(10):1228-1234. PMID: 27283779.
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    42. Weaver FA, Abraham WT, Little WC, Butter C, Ducharme A, Halbach M, Klug D, Lovett EG, Madershahian N, Müller-Ehmsen J, Schafer JE, Senni M, Swarup V, Wachter R, Zile MR. Surgical Experience and Long-term Results of Baroreflex Activation Therapy for Heart Failure With Reduced Ejection Fraction. Semin Thorac Cardiovasc Surg. 2016 Summer; 28(2):320-328. PMID: 28043438.
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    43. Desai AS, Solomon S, Claggett B, McMurray JJ, Rouleau J, Swedberg K, Zile M, Lefkowitz M, Shi V, Packer M. Factors Associated With Noncompletion During the Run-In Period Before Randomization and Influence on the Estimated Benefit of LCZ696 in the PARADIGM-HF Trial. Circ Heart Fail. 2016 Jun; 9(6). PMID: 27296397.
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    44. Cannon JA, Shen L, Jhund PS, Anand IS, Komajda M, McKelvie RS, Zile MR, Carson PE, McMurray JJ. Clinical outcomes according to QRS duration and morphology in the irbesartan in patients with heart failure and preserved systolic function (I-PRESERVE) trial. Eur J Heart Fail. 2016 08; 18(8):1021-31. PMID: 27194023.
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    45. Toba H, de Castro Brás LE, Baicu CF, Zile MR, Lindsey ML, Bradshaw AD. Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium. Am J Physiol Endocrinol Metab. 2016 06 01; 310(11):E1027-35. PMID: 27143554.
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    46. Okumura N, Jhund PS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Swedberg K, Zile MR, Solomon SD, Packer M, McMurray JJ. Importance of Clinical Worsening of Heart Failure Treated in the Outpatient Setting: Evidence From the Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial (PARADIGM-HF). Circulation. 2016 Jun 07; 133(23):2254-62. PMID: 27143684.
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    47. Brisco MA, Zile MR, Ter Maaten JM, Hanberg JS, Wilson FP, Parikh C, Testani JM. The risk of death associated with proteinuria in heart failure is restricted to patients with an elevated blood urea nitrogen to creatinine ratio. Int J Cardiol. 2016 Jul 15; 215:521-6. PMID: 27153048; PMCID: PMC4986924 [Available on 07/15/17].
    48. Santos AB, Roca GQ, Claggett B, Sweitzer NK, Shah SJ, Anand IS, Fang JC, Zile MR, Pitt B, Solomon SD, Shah AM. Prognostic Relevance of Left Atrial Dysfunction in Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2016 Apr; 9(4):e002763. PMID: 27056882; PMCID: PMC4826720 [Available on 04/01/17].
    49. Solomon SD, Claggett B, Desai AS, Packer M, Zile M, Swedberg K, Rouleau JL, Shi VC, Starling RC, Kozan Ö, Dukat A, Lefkowitz MP, McMurray JJ. Influence of Ejection Fraction on Outcomes and Efficacy of Sacubitril/Valsartan (LCZ696) in Heart Failure with Reduced Ejection Fraction: The Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) Trial. Circ Heart Fail. 2016 Mar; 9(3):e002744. PMID: 26915374.
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    50. Novgorodov SA, Riley CL, Yu J, Keffler JA, Clarke CJ, Van Laer AO, Baicu CF, Zile MR, Gudz TI. Lactosylceramide contributes to mitochondrial dysfunction in diabetes. J Lipid Res. 2016 Apr; 57(4):546-62. PMID: 26900161; PMCID: PMC4808764 [Available on 04/01/17].
    51. Zile MR, Jhund PS, Baicu CF, Claggett BL, Pieske B, Voors AA, Prescott MF, Shi V, Lefkowitz M, McMurray JJ, Solomon SD. Plasma Biomarkers Reflecting Profibrotic Processes in Heart Failure With a Preserved Ejection Fraction: Data From the Prospective Comparison of ARNI With ARB on Management of Heart Failure With Preserved Ejection Fraction Study. Circ Heart Fail. 2016 Jan; 9(1). PMID: 26754625.
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    52. Kristensen SL, Preiss D, Jhund PS, Squire I, Cardoso JS, Merkely B, Martinez F, Starling RC, Desai AS, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR, McMurray JJ, Packer M. Risk Related to Pre-Diabetes Mellitus and Diabetes Mellitus in Heart Failure With Reduced Ejection Fraction: Insights From Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial. Circ Heart Fail. 2016 Jan; 9(1). PMID: 26754626; PMCID: PMC4718182.
    53. Gallet R, de Couto G, Simsolo E, Valle J, Sun B, Liu W, Tseliou E, Zile MR, Marbán E. Cardiosphere-derived cells reverse heart failure with preserved ejection fraction (HFpEF) in rats by decreasing fibrosis and inflammation. JACC Basic Transl Sci. 2016 Jan-Feb; 1(1-2):14-28. PMID: 27104217.
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    54. Vardeny O, Claggett B, Udell JA, Packer M, Zile M, Rouleau J, Swedberg K, Desai AS, Lefkowitz M, Shi V, McMurray JJV, Solomon SD. Influenza Vaccination in Patients With Chronic Heart Failure: The PARADIGM-HF Trial. JACC Heart Fail. 2016 Feb; 4(2):152-158. PMID: 26746371.
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    55. Zile MR, Sharma V, Johnson JW, Warman EN, Baicu CF, Bennett TD. Prediction of All-Cause Mortality Based on the Direct Measurement of Intrathoracic Impedance. Circ Heart Fail. 2016 Jan; 9(1):e002543. PMID: 26699393; PMCID: PMC4692195 [Available on 01/01/17].
    56. Zile MR, Gregg D. Is Biventricular Fibrosis the Mediator of Late Complications in Tetralogy of Fallot? JACC Cardiovasc Imaging. 2016 Jan; 9(1):11-3. PMID: 26684974.
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    57. Claggett B, Packer M, McMurray JJ, Swedberg K, Rouleau J, Zile MR, Jhund P, Lefkowitz M, Shi V, Solomon SD. Estimating the Long-Term Treatment Benefits of Sacubitril-Valsartan. N Engl J Med. 2015 Dec 03; 373(23):2289-90. PMID: 26630151.
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    58. Simpson J, Jhund PS, Silva Cardoso J, Martinez F, Mosterd A, Ramires F, Rizkala AR, Senni M, Squire I, Gong J, Lefkowitz MP, Shi VC, Desai AS, Rouleau JL, Swedberg K, Zile MR, McMurray JJV, Packer M, Solomon SD. Comparing LCZ696 with enalapril according to baseline risk using the MAGGIC and EMPHASIS-HF risk scores: an analysis of mortality and morbidity in PARADIGM-HF. J Am Coll Cardiol. 2015 Nov 10; 66(19):2059-2071. PMID: 26541915.
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    59. Maisel AS, Shah KS, Barnard D, Jaski B, Frivold G, Marais J, Azer M, Miyamoto MI, Lombardo D, Kelsay D, Iqbal N, Taub PR, Kupfer K, Lee E, Clopton P, Zile M, Greenberg B. How B-Type Natriuretic Peptide (BNP) and Body Weight Changes Vary in Heart Failure With Preserved Ejection Fraction Compared With Reduced Ejection Fraction: Secondary Results of the HABIT (HF Assessment With BNP in the Home) Trial. J Card Fail. 2016 Apr; 22(4):283-93. PMID: 26433086.
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    60. Saigusa T, Dang Y, Mullick AE, Yeh ST, Zile MR, Baicu CF, Bell PD. Suppressing angiotensinogen synthesis attenuates kidney cyst formation in a Pkd1 mouse model. FASEB J. 2016 Jan; 30(1):370-9. PMID: 26391272; PMCID: PMC4684522 [Available on 01/01/17].
    61. Renaud L, Harris LG, Mani SK, Kasiganesan H, Chou JC, Baicu CF, Van Laer A, Akerman AW, Stroud RE, Jones JA, Zile MR, Menick DR. HDACs Regulate miR-133a Expression in Pressure Overload-Induced Cardiac Fibrosis. Circ Heart Fail. 2015 Nov; 8(6):1094-104. PMID: 26371176.
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    62. Kao DP, Lewsey JD, Anand IS, Massie BM, Zile MR, Carson PE, McKelvie RS, Komajda M, McMurray JJ, Lindenfeld J. Characterization of subgroups of heart failure patients with preserved ejection fraction with possible implications for prognosis and treatment response. Eur J Heart Fail. 2015 Sep; 17(9):925-35. PMID: 26250359; PMCID: PMC4654630.
    63. Jhund PS, Fu M, Bayram E, Chen CH, Negrusz-Kawecka M, Rosenthal A, Desai AS, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR, McMurray JJ, Packer M. Efficacy and safety of LCZ696 (sacubitril-valsartan) according to age: insights from PARADIGM-HF. Eur Heart J. 2015 Oct 07; 36(38):2576-84. PMID: 26231885; PMCID: PMC4595742.
    64. Badar AA, Perez-Moreno AC, Hawkins NM, Jhund PS, Brunton AP, Anand IS, McKelvie RS, Komajda M, Zile MR, Carson PE, Gardner RS, Petrie MC, McMurray JJ. Clinical Characteristics and Outcomes of Patients With Coronary Artery Disease and Angina: Analysis of the Irbesartan in Patients With Heart Failure and Preserved Systolic Function Trial. Circ Heart Fail. 2015 Jul; 8(4):717-24. PMID: 26067854.
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    65. Zile MR, Abraham WT, Weaver FA, Butter C, Ducharme A, Halbach M, Klug D, Lovett EG, Müller-Ehmsen J, Schafer JE, Senni M, Swarup V, Wachter R, Little WC. Baroreflex activation therapy for the treatment of heart failure with a reduced ejection fraction: safety and efficacy in patients with and without cardiac resynchronization therapy. Eur J Heart Fail. 2015 Oct; 17(10):1066-74. PMID: 26011593.
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    219. Zile MR. Peter C. Gazes: physician, teacher, scholar. Clin Cardiol. 2003 Mar; 26(3):158-9. PMID: 12685625.
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    221. Mukherjee R, Brinsa TA, Dowdy KB, Scott AA, Baskin JM, Deschamps AM, Lowry AS, Escobar GP, Lucas DG, Yarbrough WM, Zile MR, Spinale FG. Myocardial infarct expansion and matrix metalloproteinase inhibition. Circulation. 2003 Feb 04; 107(4):618-25. PMID: 12566376.
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    222. Baicu CF, Stroud JD, Livesay VA, Hapke E, Holder J, Spinale FG, Zile MR. Changes in extracellular collagen matrix alter myocardial systolic performance. Am J Physiol Heart Circ Physiol. 2003 Jan; 284(1):H122-32. PMID: 12485818.
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    223. Zile MR. Structural components of cardiomyocyte remodeling: summation. J Card Fail. 2002 Dec; 8(6 Suppl):S311-3. PMID: 12555137.
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    224. Creemers EE, Davis JN, Parkhurst AM, Leenders P, Dowdy KB, Hapke E, Hauet AM, Escobar PG, Cleutjens JP, Smits JF, Daemen MJ, Zile MR, Spinale FG. Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice. Am J Physiol Heart Circ Physiol. 2003 Jan; 284(1):H364-71. PMID: 12388239.
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    225. Harris TS, Baicu CF, Conrad CH, Koide M, Buckley JM, Barnes M, Cooper G, Zile MR. Constitutive properties of hypertrophied myocardium: cellular contribution to changes in myocardial stiffness. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H2173-82. PMID: 12003826.
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    226. Stroud JD, Baicu CF, Barnes MA, Spinale FG, Zile MR. Viscoelastic properties of pressure overload hypertrophied myocardium: effect of serine protease treatment. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H2324-35. PMID: 12003843.
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    227. Yun KL, Sintek CF, Miller DC, Pfeffer TA, Kochamba GS, Khonsari S, Zile MR. Randomized trial comparing partial versus complete chordal-sparing mitral valve replacement: effects on left ventricular volume and function. J Thorac Cardiovasc Surg. 2002 Apr; 123(4):707-14. PMID: 11986599.
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    228. Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure: Part II: causal mechanisms and treatment. Circulation. 2002 Mar 26; 105(12):1503-8. PMID: 11914262.
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    229. Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function. Circulation. 2002 Mar 19; 105(11):1387-93. PMID: 11901053.
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    230. Müller JG, Isomatsu Y, Koushik SV, O'Quinn M, Xu L, Kappler CS, Hapke E, Zile MR, Conway SJ, Menick DR. Cardiac-specific expression and hypertrophic upregulation of the feline Na(+)-Ca(2+) exchanger gene H1-promoter in a transgenic mouse model. Circ Res. 2002 Feb 08; 90(2):158-64. PMID: 11834708.
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    231. Zile MR, Gaasch WH, Carroll JD, Feldman MD, Aurigemma GP, Schaer GL, Ghali JK, Liebson PR. Heart failure with a normal ejection fraction: is measurement of diastolic function necessary to make the diagnosis of diastolic heart failure? Circulation. 2001 Aug 14; 104(7):779-82. PMID: 11502702.
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    232. Walker CA, Ergul A, Grubbs A, Zile MR, Zellner JL, Crumbley AJ, Spinale FG. beta-Adrenergic and endothelin receptor interaction in dilated human cardiomyopathic myocardium. J Card Fail. 2001 Jun; 7(2):129-37. PMID: 11420764.
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    233. Zile MR, Green GR, Schuyler GT, Aurigemma GP, Miller DC, Cooper G. Cardiocyte cytoskeleton in patients with left ventricular pressure overload hypertrophy. J Am Coll Cardiol. 2001 Mar 15; 37(4):1080-4. PMID: 11263612.
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    234. Ishibashi Y, Rembert JC, Carabello BA, Nemoto S, Hamawaki M, Zile MR, Greenfield JC, Cooper G. Normal myocardial function in severe right ventricular volume overload hypertrophy. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H11-6. PMID: 11123212.
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    235. Gramling-Babb PM, Zile MR, Reeves ST. Preliminary report on high thoracic epidural analgesia: relationship between its therapeutic effects and myocardial blood flow as assessed by stress thallium distribution. J Cardiothorac Vasc Anesth. 2000 Dec; 14(6):657-61. PMID: 11139104.
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    236. Laser M, Willey CD, Jiang W, Cooper G, Menick DR, Zile MR, Kuppuswamy D. Integrin activation and focal complex formation in cardiac hypertrophy. J Biol Chem. 2000 Nov 10; 275(45):35624-30. PMID: 10958798.
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    237. Zile MR, Nappi J. Diastolic Heart Failure. Curr Treat Options Cardiovasc Med. 2000 Oct; 2(5):439-450. PMID: 11096548.
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    238. Koide M, Hamawaki M, Narishige T, Sato H, Nemoto S, DeFreyte G, Zile MR, Cooper G IV, Carabello BA. Microtubule depolymerization normalizes in vivo myocardial contractile function in dogs with pressure-overload left ventricular hypertrophy. Circulation. 2000 Aug 29; 102(9):1045-52. PMID: 10961971.
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    239. Ghatpande S, Ghatpande A, Zile M, Evans T. Anterior endoderm is sufficient to rescue foregut apoptosis and heart tube morphogenesis in an embryo lacking retinoic acid. Dev Biol. 2000 Mar 01; 219(1):59-70. PMID: 10677255.
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    240. Maden M, Graham A, Zile M, Gale E. Abnormalities of somite development in the absence of retinoic acid. Int J Dev Biol. 2000; 44(1):151-9. PMID: 10761860.
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    241. Zile MR, Simsic JM. Diastolic heart failure: diagnosis and treatment. Clin Cornerstone. 2000; 3(2):13-24. PMID: 11205721.
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    242. Roten L, Nemoto S, Simsic J, Coker ML, Rao V, Baicu S, Defreyte G, Soloway PJ, Zile MR, Spinale FG. Effects of gene deletion of the tissue inhibitor of the matrix metalloproteinase-type 1 (TIMP-1) on left ventricular geometry and function in mice. J Mol Cell Cardiol. 2000 Jan; 32(1):109-20. PMID: 10652195.
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    243. Yun KL, Sintek CF, Miller DC, Schuyler GT, Fletcher AD, Pfeffer TA, Kochamba GS, Khonsari S, Zile MR. Randomized trial of partial versus complete chordal preservation methods of mitral valve replacement: A preliminary report. Circulation. 1999 Nov 09; 100(19 Suppl):II90-4. PMID: 10567284.
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    244. McElmurray JH, Mukherjee R, New RB, Sampson AC, King MK, Hendrick JW, Goldberg A, Peterson TJ, Hallak H, Zile MR, Spinale FG. Angiotensin-converting enzyme and matrix metalloproteinase inhibition with developing heart failure: comparative effects on left ventricular function and geometry. J Pharmacol Exp Ther. 1999 Nov; 291(2):799-811. PMID: 10525103.
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    245. Spinale FG, Coker ML, Krombach SR, Mukherjee R, Hallak H, Houck WV, Clair MJ, Kribbs SB, Johnson LL, Peterson JT, Zile MR. Matrix metalloproteinase inhibition during the development of congestive heart failure : effects on left ventricular dimensions and function. Circ Res. 1999 Aug 20; 85(4):364-76. PMID: 10455065.
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    246. Nagai T, Laser M, Baicu CF, Zile MR, Cooper G, Kuppuswamy D. Beta3-integrin-mediated focal adhesion complex formation: adult cardiocytes embedded in three-dimensional polymer matrices. Am J Cardiol. 1999 Jun 17; 83(12A):38H-43H. PMID: 10750585.
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    247. Stratford T, Logan C, Zile M, Maden M. Abnormal anteroposterior and dorsoventral patterning of the limb bud in the absence of retinoids. Mech Dev. 1999 Mar; 81(1-2):115-25. PMID: 10330489.
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    248. Kostetskii I, Jiang Y, Kostetskaia E, Yuan S, Evans T, Zile M. Retinoid signaling required for normal heart development regulates GATA-4 in a pathway distinct from cardiomyocyte differentiation. Dev Biol. 1999 Feb 15; 206(2):206-18. PMID: 9986733.
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    249. Koide M, Carabello BA, Conrad CC, Buckley JM, DeFreyte G, Barnes M, Tomanek RJ, Wei CC, Dell'Italia LJ, Cooper G, Zile MR. Hypertrophic response to hemodynamic overload: role of load vs. renin-angiotensin system activation. Am J Physiol. 1999 Feb; 276(2 Pt 2):H350-8. PMID: 9950833.
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    250. Zile MR, Koide M, Sato H, Ishiguro Y, Conrad CH, Buckley JM, Morgan JP, Cooper G. Role of microtubules in the contractile dysfunction of hypertrophied myocardium. J Am Coll Cardiol. 1999 Jan; 33(1):250-60. PMID: 9935038.
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    251. Kostetskii I, Yuan SY, Kostetskaia E, Linask KK, Blanchet S, Seleiro E, Michaille JJ, Brickell P, Zile M. Initial retinoid requirement for early avian development coincides with retinoid receptor coexpression in the precardiac fields and induction of normal cardiovascular development. Dev Dyn. 1998 Oct; 213(2):188-98. PMID: 9786419.
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    252. Zile MR, Richardson K, Cowles MK, Buckley JM, Koide M, Cowles BA, Gharpuray V, Cooper G. Constitutive properties of adult mammalian cardiac muscle cells. Circulation. 1998 Aug 11; 98(6):567-79. PMID: 9714115.
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    253. Matsuo T, Carabello BA, Nagatomo Y, Koide M, Hamawaki M, Zile MR, McDermott PJ. Mechanisms of cardiac hypertrophy in canine volume overload. Am J Physiol. 1998 Jul; 275(1 Pt 2):H65-74. PMID: 9688897.
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    254. Zile MR, Cowles MK, Buckley JM, Richardson K, Cowles BA, Baicu CF, Cooper G IV, Gharpuray V. Gel stretch method: a new method to measure constitutive properties of cardiac muscle cells. Am J Physiol. 1998 Jun; 274(6 Pt 2):H2188-202. PMID: 9841544.
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    255. Tagawa H, Koide M, Sato H, Zile MR, Carabello BA, Cooper G. Cytoskeletal role in the transition from compensated to decompensated hypertrophy during adult canine left ventricular pressure overloading. Circ Res. 1998 Apr 20; 82(7):751-61. PMID: 9562434.
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    256. Hamawaki M, Coffman TM, Lashus A, Koide M, Zile MR, Oliverio MI, DeFreyte G, Cooper G, Carabello BA. Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors. Am J Physiol. 1998 Mar; 274(3 Pt 2):H868-73. PMID: 9530198.
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    257. Goldfine H, Aurigemma GP, Zile MR, Gaasch WH. Left ventricular length-force-shortening relations before and after surgical correction of chronic mitral regurgitation. J Am Coll Cardiol. 1998 Jan; 31(1):180-5. PMID: 9426038.
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    258. Gramling-Babb P, Miller MJ, Reeves ST, Roy RC, Zile MR. Treatment of medically and surgically refractory angina pectoris with high thoracic epidural analgesia: initial clinical experience. Am Heart J. 1997 Jun; 133(6):648-55. PMID: 9200392.
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    259. Koide M, Nagatsu M, Zile MR, Hamawaki M, Swindle MM, Keech G, DeFreyte G, Tagawa H, Cooper G, Carabello BA. Premorbid determinants of left ventricular dysfunction in a novel model of gradually induced pressure overload in the adult canine. Circulation. 1997 Mar 18; 95(6):1601-10. PMID: 9118531.
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    260. Tagawa H, Wang N, Narishige T, Ingber DE, Zile MR, Cooper G. Cytoskeletal mechanics in pressure-overload cardiac hypertrophy. Circ Res. 1997 Feb; 80(2):281-9. PMID: 9012750.
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    261. Kato S, Koide M, Cooper G, Zile MR. Effects of pressure- or volume-overload hypertrophy on passive stiffness in isolated adult cardiac muscle cells. Am J Physiol. 1996 Dec; 271(6 Pt 2):H2575-83. PMID: 8997318.
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    262. Wada H, Zile MR, Ivester CT, Cooper G, McDermott PJ. Comparative effects of contraction and angiotensin II on growth of adult feline cardiocytes in primary culture. Am J Physiol. 1996 Jul; 271(1 Pt 2):H29-37. PMID: 8760154.
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    263. Tanaka R, Barnes MA, Cooper G, Zile MR. Effects of anisosmotic stress on cardiac muscle cell length, diameter, area, and sarcomere length. Am J Physiol. 1996 Apr; 270(4 Pt 2):H1414-22. PMID: 8967384.
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    264. Kato S, Spinale FG, Tanaka R, Johnson W, Cooper G, Zile MR. Inhibition of collagen cross-linking: effects on fibrillar collagen and ventricular diastolic function. Am J Physiol. 1995 Sep; 269(3 Pt 2):H863-8. PMID: 7573529.
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    265. Kato S, Ivester CT, Cooper G, Zile MR, McDermott PJ. Growth effects of electrically stimulated contraction on adult feline cardiocytes in primary culture. Am J Physiol. 1995 Jun; 268(6 Pt 2):H2495-504. PMID: 7611500.
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    266. Zile MR, Mukherjee R, Clayton C, Kato S, Spinale FG. Effects of chronic supraventricular pacing tachycardia on relaxation rate in isolated cardiac muscle cells. Am J Physiol. 1995 May; 268(5 Pt 2):H2104-13. PMID: 7771561.
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    267. Rozich JD, Barnes MA, Schmid PG, Zile MR, McDermott PJ, Cooper G. Load effects on gene expression during cardiac hypertrophy. J Mol Cell Cardiol. 1995 Jan; 27(1):485-99. PMID: 7760368.
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    268. Walker JD, Crawford FA, Mukherjee R, Zile MR, Spinale FG. Direct effects of acute administration of 3, 5, 3' triiodo-L-thyronine on myocyte function. Ann Thorac Surg. 1994 Sep; 58(3):851-6. PMID: 7944715.
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    269. Spinale FG, Tempel GE, Mukherjee R, Eble DM, Brown R, Vacchiano CA, Zile MR. Cellular and molecular alterations in the beta adrenergic system with cardiomyopathy induced by tachycardia. Cardiovasc Res. 1994 Aug; 28(8):1243-50. PMID: 7954628.
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    270. Hird RB, Crawford FA, Mukherjee R, Zile MR, Spinale FG. Effects of protamine on myocyte contractile function and beta-adrenergic responsiveness. Ann Thorac Surg. 1994 May; 57(5):1066-74; discussion 1074-5. PMID: 8179366.
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    271. Nagatsu M, Zile MR, Tsutsui H, Schmid PG, DeFreyte G, Cooper G, Carabello BA. Native beta-adrenergic support for left ventricular dysfunction in experimental mitral regurgitation normalizes indexes of pump and contractile function. Circulation. 1994 Feb; 89(2):818-26. PMID: 8313571.
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    272. Nagatsu M, Ishihara K, Zile MR, Tsutsui H, Tagawa H, DeFreyte G, Tanaka R, Cooper G, Carabello BA. The effects of complete versus incomplete mitral valve repair in experimental mitral regurgitation. J Thorac Cardiovasc Surg. 1994 Feb; 107(2):416-23. PMID: 8302060.
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    273. Assey ME, Zile MR, Usher BW, Karavan MP, Carabello BA. Effect of catheter positioning on the variability of measured gradient in aortic stenosis. Cathet Cardiovasc Diagn. 1993 Dec; 30(4):287-92. PMID: 8287452.
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    274. Spinale FG, Ishihra K, Zile M, DeFryte G, Crawford FA, Carabello BA. Structural basis for changes in left ventricular function and geometry because of chronic mitral regurgitation and after correction of volume overload. J Thorac Cardiovasc Surg. 1993 Dec; 106(6):1147-57. PMID: 8246553.
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    275. Tanaka R, Fulbright BM, Mukherjee R, Burchell SA, Crawford FA, Zile MR, Spinale FG. The cellular basis for the blunted response to beta-adrenergic stimulation in supraventricular tachycardia-induced cardiomyopathy. J Mol Cell Cardiol. 1993 Oct; 25(10):1215-33. PMID: 8263955.
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    276. Tsutsui H, Urabe Y, Mann DL, Tagawa H, Carabello BA, Cooper G, Zile MR. Effects of chronic mitral regurgitation on diastolic function in isolated cardiocytes. Circ Res. 1993 May; 72(5):1110-23. PMID: 8477523.
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    277. Zile MR, Tomita M, Ishihara K, Nakano K, Lindroth J, Spinale F, Swindle M, Carabello BA. Changes in diastolic function during development and correction of chronic LV volume overload produced by mitral regurgitation. Circulation. 1993 Apr; 87(4):1378-88. PMID: 8462159.
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    278. Spinale FG, Mukherjee R, Fulbright BM, Hu J, Crawford FA, Zile MR. Contractile properties of isolated porcine ventricular myocytes. Cardiovasc Res. 1993 Feb; 27(2):304-11. PMID: 8472283.
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    279. Rozich JD, Carabello BA, Usher BW, Kratz JM, Bell AE, Zile MR. Mitral valve replacement with and without chordal preservation in patients with chronic mitral regurgitation. Mechanisms for differences in postoperative ejection performance. Circulation. 1992 Dec; 86(6):1718-26. PMID: 1451243.
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    280. Ishihara K, Zile MR, Nagatsu M, Nakano K, Tomita M, Kanazawa S, Clamp L, DeFreyte G, Carabello BA. Coronary blood flow after the regression of pressure-overload left ventricular hypertrophy. Circ Res. 1992 Dec; 71(6):1472-81. PMID: 1423939.
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    281. Tanaka R, Spinale FG, Crawford FA, Zile MR. Effect of chronic supraventricular tachycardia on left ventricular function and structure in newborn pigs. J Am Coll Cardiol. 1992 Dec; 20(7):1650-60. PMID: 1452940.
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    282. Cannon JD, Zile MR, Crawford FA, Carabello BA. Aortic valve resistance as an adjunct to the Gorlin formula in assessing the severity of aortic stenosis in symptomatic patients. J Am Coll Cardiol. 1992 Dec; 20(7):1517-23. PMID: 1452925.
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    283. Ishihara K, Zile MR, Kanazawa S, Tsutsui H, Urabe Y, DeFreyte G, Carabello BA. Left ventricular mechanics and myocyte function after correction of experimental chronic mitral regurgitation by combined mitral valve replacement and preservation of the native mitral valve apparatus. Circulation. 1992 Nov; 86(5 Suppl):II16-25. PMID: 1423995.
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    284. Burchell SA, Spinale FG, Crawford FA, Tanaka R, Zile MR. Effects of chronic tachycardia-induced cardiomyopathy on the beta-adrenergic receptor system. J Thorac Cardiovasc Surg. 1992 Oct; 104(4):1006-12. PMID: 1328769.
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    285. Carabello BA, Zile MR, Tanaka R, Cooper G. Left ventricular hypertrophy due to volume overload versus pressure overload. Am J Physiol. 1992 Oct; 263(4 Pt 2):H1137-44. PMID: 1415762.
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    286. Zile MR, Tanaka R, Lindroth JR, Spinale F, Carabello BA, Mirsky I. Left ventricular volume determined echocardiographically by assuming a constant left ventricular epicardial long-axis/short-axis dimension ratio throughout the cardiac cycle. J Am Coll Cardiol. 1992 Oct; 20(4):986-93. PMID: 1388183.
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    287. Spinale FG, Fulbright BM, Mukherjee R, Tanaka R, Hu J, Crawford FA, Zile MR. Relation between ventricular and myocyte function with tachycardia-induced cardiomyopathy. Circ Res. 1992 Jul; 71(1):174-87. PMID: 1606661.
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    288. Ishihara K, Zile MR, Tomita M, Tanaka R, Kanazawa S, Carabello BA. Left ventricular hypertrophy in a canine model of reversible pressure overload. Cardiovasc Res. 1992 Jun; 26(6):580-5. PMID: 1451137.
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    289. Gwinn N, Leman R, Kratz J, White JK, Zile MR, Gillette P. Chronotropic incompetence: a common and progressive finding in pacemaker patients. Am Heart J. 1992 May; 123(5):1216-9. PMID: 1575136.
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    290. Spinale FG, Mukherjee R, Tanaka R, Zile MR. The effects of valvular regurgitation on thermodilution ejection fraction measurements. Chest. 1992 Mar; 101(3):723-31. PMID: 1541138.
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    291. Spinale FG, Clayton C, Tanaka R, Fulbright BM, Mukherjee R, Schulte BA, Crawford FA, Zile MR. Myocardial Na+,K(+)-ATPase in tachycardia induced cardiomyopathy. J Mol Cell Cardiol. 1992 Mar; 24(3):277-94. PMID: 1320703.
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    292. Spinale FG, Tanaka R, Crawford FA, Zile MR. Changes in myocardial blood flow during development of and recovery from tachycardia-induced cardiomyopathy. Circulation. 1992 Feb; 85(2):717-29. PMID: 1735164.
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    293. Spinale FG, Grine RC, Tempel GE, Crawford FA, Zile MR. Alterations in the myocardial capillary vasculature accompany tachycardia-induced cardiomyopathy. Basic Res Cardiol. 1992 Jan-Feb; 87(1):65-79. PMID: 1567354.
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    294. Zile MR, Tomita M, Nakano K, Mirsky I, Usher B, Lindroth J, Carabello BA. Effects of left ventricular volume overload produced by mitral regurgitation on diastolic function. Am J Physiol. 1991 Nov; 261(5 Pt 2):H1471-80. PMID: 1951734.
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    295. Spinale FG, Zellner JL, Tomita M, Crawford FA, Zile MR. Relation between ventricular and myocyte remodeling with the development and regression of supraventricular tachycardia-induced cardiomyopathy. Circ Res. 1991 Oct; 69(4):1058-67. PMID: 1934334.
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    296. Zile MR, Gaasch WH. Load-dependent left ventricular relaxation in conscious dogs. Am J Physiol. 1991 Sep; 261(3 Pt 2):H691-9. PMID: 1887917.
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    297. Izzi G, Zile MR, Gaasch WH. Myocardial oxygen consumption and the left ventricular pressure-volume area in normal and hypertrophic canine hearts. Circulation. 1991 Sep; 84(3):1384-92. PMID: 1832096.
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    298. Spinale FG, Tomita M, Zellner JL, Cook JC, Crawford FA, Zile MR. Collagen remodeling and changes in LV function during development and recovery from supraventricular tachycardia. Am J Physiol. 1991 Aug; 261(2 Pt 2):H308-18. PMID: 1877659.
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    299. Gaasch WH, Zile MR. Left ventricular function after surgical correction of chronic mitral regurgitation. Eur Heart J. 1991 Jul; 12 Suppl B:48-51. PMID: 1936024.
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    300. Spinale FG, Zellner JL, Tomita M, Tempel GE, Crawford FA, Zile MR. Tachycardia-induced cardiomyopathy: effects on blood flow and capillary structure. Am J Physiol. 1991 Jul; 261(1 Pt 2):H140-8. PMID: 1858914.
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    301. Nakano K, Swindle MM, Spinale F, Ishihara K, Kanazawa S, Smith A, Biederman RW, Clamp L, Hamada Y, Zile MR, et al. Depressed contractile function due to canine mitral regurgitation improves after correction of the volume overload. J Clin Invest. 1991 Jun; 87(6):2077-86. PMID: 1828252; PMCID: PMC296964.
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    303. Rozich JD, Smith B, Thomas JD, Zile MR, Kaiser J, Mann DL. Dialysis-induced alterations in left ventricular filling: mechanisms and clinical significance. Am J Kidney Dis. 1991 Mar; 17(3):277-85. PMID: 1996569.
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    304. Zile MR, Izzi G, Gaasch WH. Left ventricular diastolic dysfunction limits use of maximum systolic elastance as an index of contractile function. Circulation. 1991 Feb; 83(2):674-80. PMID: 1825039.
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    305. Tomita M, Spinale FG, Crawford FA, Zile MR. Changes in left ventricular volume, mass, and function during the development and regression of supraventricular tachycardia-induced cardiomyopathy. Disparity between recovery of systolic versus diastolic function. Circulation. 1991 Feb; 83(2):635-44. PMID: 1991381.
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    306. Swindle MM, Spinale FG, Smith AC, Schumann RE, Green CT, Nakano K, Kanasawa S, Ishihara K, Zile MR, Carabello BA. Anesthetic and postoperative protocols for a canine model of reversible left ventricular volume overload. J Invest Surg. 1991; 4(3):339-46. PMID: 1832953.
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    307. Gaasch WH, Zile MR, Hoshino PK, Weinberg EO, Rhodes DR, Apstein CS. Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload hypertrophy. Circulation. 1990 May; 81(5):1644-53. PMID: 2139593.
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    308. Zile MR, Gaasch WH. Mechanical loads and the isovolumic and filling indices of left ventricular relaxation. Prog Cardiovasc Dis. 1990 Mar-Apr; 32(5):333-46. PMID: 2179994.
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    309. Zile MR, Conrad CH, Gaasch WH, Robinson KG, Bing OH. Preload does not affect relaxation rate in normal, hypoxic, or hypertrophic myocardium. Am J Physiol. 1990 Jan; 258(1 Pt 2):H191-7. PMID: 2137298.
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    310. Zile MR, Blaustein AS, Gaasch WH. The effect of acute alterations in left ventricular afterload and beta-adrenergic tone on indices of early diastolic filling rate. Circ Res. 1989 Aug; 65(2):406-16. PMID: 2546696.
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    311. Gaasch WH, Zile MR, Hoshino PK, Apstein CS, Blaustein AS. Stress-shortening relations and myocardial blood flow in compensated and failing canine hearts with pressure-overload hypertrophy. Circulation. 1989 Apr; 79(4):872-83. PMID: 2522357.
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    312. Zile MR, Neill WA, Gaasch WH, Oxendine J, Apstein CS, Weinberg E, Bing OH. Distribution of a neutral cardioplegic vehicle during the development of ischemic myocardial contracture. J Mol Cell Cardiol. 1987 Oct; 19(10):977-89. PMID: 2449532.
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    313. Zile MR, Blaustein AS, Shimizu G, Gaasch WH. Right ventricular pacing reduces the rate of left ventricular relaxation and filling. J Am Coll Cardiol. 1987 Sep; 10(3):702-9. PMID: 3624674.
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    314. Zile MR, Gaasch WH, Wiegner AW, Robinson KG, Bing OH. Mechanical determinants of maximum isotonic lengthening rate in rat left ventricular myocardium. Circ Res. 1987 Jun; 60(6):815-23. PMID: 3594754.
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    315. Konstam MA, Weiland DS, Conlon TP, Martin TT, Cohen SR, Eichhorn EJ, Isner JM, Zile MR, Salem DN. Hemodynamic correlates of left ventricular versus right ventricular radionuclide volumetric responses to vasodilator therapy in congestive heart failure secondary to ischemic or dilated cardiomyopathy. Am J Cardiol. 1987 May 01; 59(12):1131-7. PMID: 3578055.
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    316. Weiland DS, Konstam MA, Salem DN, Martin TT, Cohen SR, Zile MR, Das D. Contribution of reduced mitral regurgitant volume to vasodilator effect in severe left ventricular failure secondary to coronary artery disease or idiopathic dilated cardiomyopathy. Am J Cardiol. 1986 Nov 01; 58(10):1046-50. PMID: 3776843.
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    317. Zile MR, Gaasch WH, Levine HJ. Left ventricular stress-dimension-shortening relations before and after correction of chronic aortic and mitral regurgitation. Am J Cardiol. 1985 Jul 01; 56(1):99-105. PMID: 3160230.
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    318. Konstam MA, Cohen SR, Salem DN, Conlon TP, Isner JM, Das D, Zile MR, Levine HJ, Kahn PC. Comparison of left and right ventricular end-systolic pressure-volume relations in congestive heart failure. J Am Coll Cardiol. 1985 Jun; 5(6):1326-34. PMID: 3923077.
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    319. Shimizu G, Zile MR, Blaustein AS, Gaasch WH. Left ventricular chamber filling and midwall fiber lengthening in patients with left ventricular hypertrophy: overestimation of fiber velocities by conventional midwall measurements. Circulation. 1985 Feb; 71(2):266-72. PMID: 3155498.
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    320. Gaasch WH, Zile MR. Evaluation of myocardial function in cardiomyopathic states. Prog Cardiovasc Dis. 1984 Sep-Oct; 27(2):115-32. PMID: 6382437.
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    321. Konstam MA, Salem DN, Isner JM, Zile MR, Kahn PC, Bonin JD, Cohen SR, Levine HJ. Vasodilator effect on right ventricular function in congestive heart failure and pulmonary hypertension: end-systolic pressure--volume relation. Am J Cardiol. 1984 Jul 01; 54(1):132-6. PMID: 6430055.
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    322. Zile MR, Gaasch WH, Carroll JD, Levine HJ. Chronic mitral regurgitation: predictive value of preoperative echocardiographic indexes of left ventricular function and wall stress. J Am Coll Cardiol. 1984 Feb; 3(2 Pt 1):235-42. PMID: 6693615.
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    323. Carroll JD, Gaasch WH, Zile MR, Levine HJ. Serial changes in left ventricular function after correction of chronic aortic regurgitation. Dependence on early changes in preload and subsequent regression of hypertrophy. Am J Cardiol. 1983 Feb; 51(3):476-82. PMID: 6218744.
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    324. Coffey RL, Zile MR, Luskin AT. Immunologic tests of value in diagnosis. 1. Acute phase reactants and autoantibodies. Postgrad Med. 1981 Aug; 70(2):163-78. PMID: 7019872.
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    325. Coffey RL, Zile MR, Luskin AT. Immunologic tests of value in diagnosis. 2. Complement. Postgrad Med. 1981 Aug; 70(2):183-8. PMID: 7019873.
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    326. Ito YL, Zile M, Ahrens H, DeLuca HF. Liquid-gel partition chromatography of vitamin A compounds; formation of retinoic acid from retinyl acetate in vivo. J Lipid Res. 1974 Sep; 15(5):517-24. PMID: 4414497.
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