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Last Name
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Lindsay M. Squeglia

Title
InstitutionMedical University of South Carolina
DepartmentPsychiatry and Behavioral Sciences
AddressP.O. Box MSC 861
IOP 474N
67 President St.
Phone843-792-5451
Fax843-792-7353
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    Collapse Overview 
    Collapse overview
    Dr. Squeglia's research focuses on understanding the effects of alcohol and marijuana use on adolescent brain development, using structural and functional neuroimaging and neuropsychological testing, as well as creating effective treatment options for substance-using youth. She is funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA).

    Collapse keywords
    Substance Use, Adolescents, Drug Studies, Psychiatry, Alcohol, Brain, Pediatrics

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wade NE, Bagot KS, Cota CI, Fotros A, Squeglia LM, Meredith LR, Jacobus J. Orbitofrontal cortex volume prospectively predicts cannabis and other substance use onset in adolescents. J Psychopharmacol. 2019 Jun 19; 269881119855971. PMID: 31215833.
      View in: PubMed
    2. Fadus MC, Smith TT, Squeglia LM. The rise of e-cigarettes, pod mod devices, and JUUL among youth: Factors influencing use, health implications, and downstream effects. Drug Alcohol Depend. 2019 Aug 01; 201:85-93. PMID: 31200279.
      View in: PubMed
    3. Karoly HC, Schacht JP, Jacobus J, Meredith LR, Taylor CT, Tapert SF, Gray KM, Squeglia LM. Preliminary evidence that computerized approach avoidance training is not associated with changes in fMRI cannabis cue reactivity in non-treatment-seeking adolescent cannabis users. Drug Alcohol Depend. 2019 Jul 01; 200:145-152. PMID: 31132681.
      View in: PubMed
    4. Squeglia LM, Fadus MC, McClure EA, Tomko RL, Gray KM. Pharmacological Treatment of Youth Substance Use Disorders. J Child Adolesc Psychopharmacol. 2019 Apr 22. PMID: 31009234.
      View in: PubMed
    5. Hoffman EA, Clark DB, Orendain N, Hudziak J, Squeglia LM, Dowling GJ. Stress exposures, neurodevelopment and health measures in the ABCD study. Neurobiol Stress. 2019 Feb; 10:100157. PMID: 30949565.
      View in: PubMed
    6. Silvers JA, Squeglia LM, Rømer Thomsen K, Hudson KA, Feldstein Ewing SW. Hunting for What Works: Adolescents in Addiction Treatment. Alcohol Clin Exp Res. 2019 Apr; 43(4):578-592. PMID: 30779445.
      View in: PubMed
    7. Salazar CA, Tomko RL, Akbar SA, Squeglia LM, McClure EA. Medical Cannabis Use among Adults in the Southeastern United States. Cannabis. 2019 Feb 09; 2(1):53-65. PMID: 30815638.
      View in: PubMed
    8. Fadus MC, Odunsi OT, Squeglia LM. Race, Ethnicity, and Culture in the Medical Record: Implicit Bias or Patient Advocacy? Acad Psychiatry. 2019 Feb 07. PMID: 30734262.
      View in: PubMed
    9. Tomko RL, McClure EA, Squeglia LM, Treloar Padovano H, McRae-Clark AL, Baker NL, Carpenter MJ, Gray KM. Methods to reduce the incidence of false negative trial results in substance use treatment research. Curr Opin Psychol. 2019 Jan 28; 30:35-41. PMID: 30798020.
      View in: PubMed
    10. McClure EA, Tomko RL, Salazar CA, Akbar SA, Squeglia LM, Herrmann E, Carpenter MJ, Peters EN. Tobacco and cannabis co-use: Drug substitution, quit interest, and cessation preferences. Exp Clin Psychopharmacol. 2019 Jun; 27(3):265-275. PMID: 30556733.
      View in: PubMed
    11. Akbar SA, Tomko RL, Salazar CA, Squeglia LM, McClure EA. Tobacco and cannabis co-use and interrelatedness among adults. Addict Behav. 2019 Mar; 90:354-361. PMID: 30522075.
      View in: PubMed
    12. Infante MA, Courtney KE, Castro N, Squeglia LM, Jacobus J. Adolescent Brain Surface Area Pre- and Post-Cannabis and Alcohol Initiation. J Stud Alcohol Drugs. 2018 Nov; 79(6):835-843. PMID: 30573013.
      View in: PubMed
    13. Paulus MP, Squeglia LM, Bagot K, Jacobus J, Kuplicki R, Breslin FJ, Bodurka J, Morris AS, Thompson WK, Bartsch H, Tapert SF. Screen media activity and brain structure in youth: Evidence for diverse structural correlation networks from the ABCD study. Neuroimage. 2019 01 15; 185:140-153. PMID: 30339913.
      View in: PubMed
    14. Karoly HC, Schacht JP, Meredith LR, Jacobus J, Tapert SF, Gray KM, Squeglia LM. Investigating a novel fMRI cannabis cue reactivity task in youth. Addict Behav. 2019 Feb; 89:20-28. PMID: 30243035.
      View in: PubMed
    15. Nguyen-Louie TT, Courtney KE, Squeglia LM, Bagot K, Eberson S, Migliorini R, Alcaraz AR, Tapert SF, Pulido C. Prospective changes in neural alcohol cue reactivity in at-risk adolescents. Brain Imaging Behav. 2018 Aug; 12(4):931-941. PMID: 28801730.
      View in: PubMed
    16. Lees B, Mewton L, Stapinski L, Squeglia LM, Rae C, Teesson M. Binge drinking in young people: protocol for a systematic review of neuropsychological, neurophysiological and neuroimaging studies. BMJ Open. 2018 07 30; 8(7):e023629. PMID: 30061448.
      View in: PubMed
    17. Jacobus J, Taylor CT, Gray KM, Meredith LR, Porter AM, Li I, Castro N, Squeglia LM. A multi-site proof-of-concept investigation of computerized approach-avoidance training in adolescent cannabis users. Drug Alcohol Depend. 2018 06 01; 187:195-204. PMID: 29679914.
      View in: PubMed
    18. Bagot KS, Matthews SA, Mason M, Squeglia LM, Fowler J, Gray K, Herting M, May A, Colrain I, Godino J, Tapert S, Brown S, Patrick K. Current, future and potential use of mobile and wearable technologies and social media data in the ABCD study to increase understanding of contributors to child health. Dev Cogn Neurosci. 2018 08; 32:121-129. PMID: 29636283.
      View in: PubMed
    19. Morris AS, Squeglia LM, Jacobus J, Silk JS. Adolescent Brain Development: Implications for Understanding Risk and Resilience Processes Through Neuroimaging Research. J Res Adolesc. 2018 Mar; 28(1):4-9. PMID: 29460349.
      View in: PubMed
    20. Squeglia LM, Tomko RL, Baker NL, McClure EA, Book GA, Gray KM. The effect of N-acetylcysteine on alcohol use during a cannabis cessation trial. Drug Alcohol Depend. 2018 04 01; 185:17-22. PMID: 29413434.
      View in: PubMed
    21. Sherman BJ, Baker NL, Squeglia LM, McRae-Clark AL. Approach bias modification for cannabis use disorder: A proof-of-principle study. J Subst Abuse Treat. 2018 Apr; 87:16-22. PMID: 29471922.
      View in: PubMed
    22. Nguyen-Louie TT, Simmons AN, Squeglia LM, Alejandra Infante M, Schacht JP, Tapert SF. Earlier alcohol use onset prospectively predicts changes in functional connectivity. Psychopharmacology (Berl). 2018 04; 235(4):1041-1054. PMID: 29306963.
      View in: PubMed
    23. Jacobus J, Squeglia LM, Escobar S, McKenna BM, Hernandez MM, Bagot KS, Taylor CT, Huestis MA. Changes in marijuana use symptoms and emotional functioning over 28-days of monitored abstinence in adolescent marijuana users. Psychopharmacology (Berl). 2017 Dec; 234(23-24):3431-3442. PMID: 28900686.
      View in: PubMed
    24. Gray KM, Squeglia LM. Research Review: What have we learned about adolescent substance use? J Child Psychol Psychiatry. 2018 06; 59(6):618-627. PMID: 28714184.
      View in: PubMed
    25. Nguyen-Louie TT, Brumback T, Worley MJ, Colrain IM, Matt GE, Squeglia LM, Tapert SF. Effects of sleep on substance use in adolescents: a longitudinal perspective. Addict Biol. 2018 03; 23(2):750-760. PMID: 28547821.
      View in: PubMed
    26. Squeglia LM, Cservenka A. Adolescence and Drug Use Vulnerability: Findings from Neuroimaging. Curr Opin Behav Sci. 2017 Feb; 13:164-170. PMID: 28111629.
      View in: PubMed
    27. Jacobus J, Castro N, Squeglia LM, Meloy MJ, Brumback T, Huestis MA, Tapert SF. Reprint of "Adolescent cortical thickness pre- and post marijuana and alcohol initiation". Neurotoxicol Teratol. 2016 Nov - Dec; 58:78-87. PMID: 27856361.
      View in: PubMed
    28. Tomko RL, Saladin ME, McClure EA, Squeglia LM, Carpenter MJ, Tiffany ST, Baker NL, Gray KM. Alcohol consumption as a predictor of reactivity to smoking and stress cues presented in the natural environment of smokers. Psychopharmacology (Berl). 2017 Feb; 234(3):427-435. PMID: 27838746.
      View in: PubMed
    29. Brumback TY, Worley M, Nguyen-Louie TT, Squeglia LM, Jacobus J, Tapert SF. Neural predictors of alcohol use and psychopathology symptoms in adolescents. Dev Psychopathol. 2016 11; 28(4pt1):1209-1216. PMID: 27739397.
      View in: PubMed
    30. Jacobus J, Castro N, Squeglia LM, Meloy MJ, Brumback T, Huestis MA, Tapert SF. Adolescent cortical thickness pre- and post marijuana and alcohol initiation. Neurotoxicol Teratol. 2016 Sep - Oct; 57:20-29. PMID: 27687470.
      View in: PubMed
    31. Squeglia LM, Ball TM, Jacobus J, Brumback T, McKenna BS, Nguyen-Louie TT, Sorg SF, Paulus MP, Tapert SF. Neural Predictors of Initiating Alcohol Use During Adolescence. Am J Psychiatry. 2017 Feb 01; 174(2):172-185. PMID: 27539487.
      View in: PubMed
    32. Squeglia LM, Baker NL, McClure EA, Tomko RL, Adisetiyo V, Gray KM. Alcohol use during a trial of N-acetylcysteine for adolescent marijuana cessation. Addict Behav. 2016 12; 63:172-7. PMID: 27521979.
      View in: PubMed
    33. Nguyen-Louie TT, Tracas A, Squeglia LM, Matt GE, Eberson-Shumate S, Tapert SF. Learning and Memory in Adolescent Moderate, Binge, and Extreme-Binge Drinkers. Alcohol Clin Exp Res. 2016 09; 40(9):1895-904. PMID: 27462830.
      View in: PubMed
    34. Squeglia LM, Gray KM. Alcohol and Drug Use and the Developing Brain. Curr Psychiatry Rep. 2016 May; 18(5):46. PMID: 26984684.
      View in: PubMed
    35. Squeglia LM, Brammer WA, Ray LA, Lee SS. Attention Deficit/Hyperactivity Disorder (ADHD) Symptoms Predict Alcohol Expectancy Development. J Child Adolesc Subst Abuse. 2016 Mar 01; 25(2):159-179. PMID: 27110089.
      View in: PubMed
    36. Nguyen-Louie TT, Castro N, Matt GE, Squeglia LM, Brumback T, Tapert SF. Effects of Emerging Alcohol and Marijuana Use Behaviors on Adolescents' Neuropsychological Functioning Over Four Years. J Stud Alcohol Drugs. 2015 Sep; 76(5):738-48. PMID: 26402354.
      View in: PubMed
    37. Squeglia LM, Tapert SF, Sullivan EV, Jacobus J, Meloy MJ, Rohlfing T, Pfefferbaum A. Brain development in heavy-drinking adolescents. Am J Psychiatry. 2015 Jun; 172(6):531-42. PMID: 25982660.
      View in: PubMed
    38. Jacobus J, Squeglia LM, Infante MA, Castro N, Brumback T, Meruelo AD, Tapert SF. Neuropsychological performance in adolescent marijuana users with co-occurring alcohol use: A three-year longitudinal study. Neuropsychology. 2015 Nov; 29(6):829-843. PMID: 25938918.
      View in: PubMed
    39. Jacobus J, Squeglia LM, Meruelo AD, Castro N, Brumback T, Giedd JN, Tapert SF. Cortical thickness in adolescent marijuana and alcohol users: A three-year prospective study from adolescence to young adulthood. Dev Cogn Neurosci. 2015 Dec; 16:101-109. PMID: 25953106.
      View in: PubMed
    40. Brumback T, Squeglia LM, Jacobus J, Pulido C, Tapert SF, Brown SA. Adolescent heavy drinkers' amplified brain responses to alcohol cues decrease over one month of abstinence. Addict Behav. 2015 Jul; 46:45-52. PMID: 25796007.
      View in: PubMed
    41. Sorg SF, Squeglia LM, Taylor MJ, Alhassoon OM, Delano-Wood LM, Grant I. Effects of aging on frontal white matter microstructure in alcohol use disorder and associations with processing speed. J Stud Alcohol Drugs. 2015 Mar; 76(2):296-306. PMID: 25785805.
      View in: PubMed
    42. Squeglia LM, Sorg SF, Jacobus J, Brumback T, Taylor CT, Tapert SF. Structural connectivity of neural reward networks in youth at risk for substance use disorders. Psychopharmacology (Berl). 2015 Jul; 232(13):2217-26. PMID: 25563237.
      View in: PubMed
    43. Jacobus J, Squeglia LM, Sorg SF, Nguyen-Louie TT, Tapert SF. Cortical thickness and neurocognition in adolescent marijuana and alcohol users following 28 days of monitored abstinence. J Stud Alcohol Drugs. 2014 Sep; 75(5):729-43. PMID: 25208190.
      View in: PubMed
    44. Squeglia LM, Boissoneault J, Van Skike CE, Nixon SJ, Matthews DB. Age-related effects of alcohol from adolescent, adult, and aged populations using human and animal models. Alcohol Clin Exp Res. 2014 Oct; 38(10):2509-16. PMID: 25156779.
      View in: PubMed
    45. Squeglia LM, Jacobus J, Nguyen-Louie TT, Tapert SF. Inhibition during early adolescence predicts alcohol and marijuana use by late adolescence. Neuropsychology. 2014 Sep; 28(5):782-790. PMID: 24749728.
      View in: PubMed
    46. Squeglia LM, Jacobus J, Brumback T, Meloy MJ, Tapert SF. White matter integrity in alcohol-naive youth with a family history of alcohol use disorders. Psychol Med. 2014 Oct; 44(13):2775-86. PMID: 25066702.
      View in: PubMed
    47. Squeglia LM, Rinker DA, Bartsch H, Castro N, Chung Y, Dale AM, Jernigan TL, Tapert SF. Brain volume reductions in adolescent heavy drinkers. Dev Cogn Neurosci. 2014 Jul; 9:117-25. PMID: 24632141.
      View in: PubMed
    48. Ray LA, Bujarski S, Squeglia LM, Ashenhurst JR, Anton RF. Interactive effects of OPRM1 and DAT1 genetic variation on subjective responses to alcohol. Alcohol Alcohol. 2014 May-Jun; 49(3):261-70. PMID: 24421289.
      View in: PubMed
    49. Squeglia LM, Jacobus J, Tapert SF. The effect of alcohol use on human adolescent brain structures and systems. Handb Clin Neurol. 2014; 125:501-10. PMID: 25307592.
      View in: PubMed
    50. Jacobus J, Squeglia LM, Bava S, Tapert SF. White matter characterization of adolescent binge drinking with and without co-occurring marijuana use: a 3-year investigation. Psychiatry Res. 2013 Dec 30; 214(3):374-81. PMID: 24139957.
      View in: PubMed
    51. Squeglia LM, McKenna BS, Jacobus J, Castro N, Sorg SF, Tapert SF. BOLD response to working memory not related to cortical thickness during early adolescence. Brain Res. 2013 Nov 06; 1537:59-68. PMID: 24012876.
      View in: PubMed
    52. Squeglia LM, Jacobus J, Sorg SF, Jernigan TL, Tapert SF. Early adolescent cortical thinning is related to better neuropsychological performance. J Int Neuropsychol Soc. 2013 Oct; 19(9):962-70. PMID: 23947395.
      View in: PubMed
    53. Wetherill RR, Squeglia LM, Yang TT, Tapert SF. A longitudinal examination of adolescent response inhibition: neural differences before and after the initiation of heavy drinking. Psychopharmacology (Berl). 2013 Dec; 230(4):663-71. PMID: 23832422.
      View in: PubMed
    54. Jacobus J, Squeglia LM, Infante MA, Bava S, Tapert SF. White matter integrity pre- and post marijuana and alcohol initiation in adolescence. Brain Sci. 2013 Mar 22; 3(1):396-414. PMID: 23914300.
      View in: PubMed
    55. Lisdahl KM, Thayer R, Squeglia LM, McQueeny TM, Tapert SF. Recent binge drinking predicts smaller cerebellar volumes in adolescents. Psychiatry Res. 2013 Jan 30; 211(1):17-23. PMID: 23154095.
      View in: PubMed
    56. Wetherill RR, Castro N, Squeglia LM, Tapert SF. Atypical neural activity during inhibitory processing in substance-naïve youth who later experience alcohol-induced blackouts. Drug Alcohol Depend. 2013 Mar 01; 128(3):243-9. PMID: 23021773.
      View in: PubMed
    57. Squeglia LM, Pulido C, Wetherill RR, Jacobus J, Brown GG, Tapert SF. Brain response to working memory over three years of adolescence: influence of initiating heavy drinking. J Stud Alcohol Drugs. 2012 Sep; 73(5):749-60. PMID: 22846239.
      View in: PubMed
    58. Ray LA, Courtney KE, Bujarski S, Squeglia LM. Pharmacogenetics of alcoholism: a clinical neuroscience perspective. Pharmacogenomics. 2012 Jan; 13(2):129-32. PMID: 22256863.
      View in: PubMed
    59. Squeglia LM, Sorg SF, Schweinsburg AD, Wetherill RR, Pulido C, Tapert SF. Binge drinking differentially affects adolescent male and female brain morphometry. Psychopharmacology (Berl). 2012 Apr; 220(3):529-39. PMID: 21952669.
      View in: PubMed
    60. Norman AL, Pulido C, Squeglia LM, Spadoni AD, Paulus MP, Tapert SF. Neural activation during inhibition predicts initiation of substance use in adolescence. Drug Alcohol Depend. 2011 Dec 15; 119(3):216-23. PMID: 21782354.
      View in: PubMed
    61. Squeglia LM, Schweinsburg AD, Pulido C, Tapert SF. Adolescent binge drinking linked to abnormal spatial working memory brain activation: differential gender effects. Alcohol Clin Exp Res. 2011 Oct; 35(10):1831-41. PMID: 21762178.
      View in: PubMed
    62. Squeglia LM, Spadoni AD, Infante MA, Myers MG, Tapert SF. Initiating moderate to heavy alcohol use predicts changes in neuropsychological functioning for adolescent girls and boys. Psychol Addict Behav. 2009 Dec; 23(4):715-22. PMID: 20025379.
      View in: PubMed
    63. Squeglia LM, Jacobus J, Tapert SF. The influence of substance use on adolescent brain development. Clin EEG Neurosci. 2009 Jan; 40(1):31-8. PMID: 19278130.
      View in: PubMed
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