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Lawrence D Middaugh

Title
InstitutionMedical University of South Carolina
DepartmentPsychiatry and Behavioral Sciences
AddressP.O. Box MSC 861
PH556
67 President St.
Phone843-792-3066
Fax843-792-7353
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Karakostas T, Hsiang S, Boger H, Middaugh L, Granholm AC. Three-dimensional rodent motion analysis and neurodegenerative disorders. J Neurosci Methods. 2014 Jul 15; 231:31-7. PMID: 24129039.
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    2. Griffin WC, McGovern RW, Bell GH, Randall PK, Middaugh LD, Patrick KS. Interactive effects of methylphenidate and alcohol on discrimination, conditioned place preference and motor coordination in C57BL/6J mice. Psychopharmacology (Berl). 2013 Feb; 225(3):613-25. PMID: 22955568.
      View in: PubMed
    3. Griffin WC, Nguyen SA, Deleon CP, Middaugh LD. Effects of vigabatrin, an irreversible GABA transaminase inhibitor, on ethanol reinforcement and ethanol discriminative stimuli in mice. Behav Pharmacol. 2012 Apr; 23(2):178-90. PMID: 22336593.
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    4. McGovern RW, Middaugh LD, Patrick KS, Griffin WC. The discriminative stimulus properties of methylphenidate in C57BL/6J mice. Behav Pharmacol. 2011 Feb; 22(1):14-22. PMID: 21160424.
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    5. Granholm AC, Zaman V, Godbee J, Smith M, Ramadan R, Umphlet C, Randall P, Bhat NR, Rohrer B, Middaugh LD, Boger HA. Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice. Brain Pathol. 2011 May; 21(3):330-48. PMID: 20969653.
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    6. Littrell OM, Pomerleau F, Huettl P, Surgener S, McGinty JF, Middaugh LD, Granholm AC, Gerhardt GA, Boger HA. Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice. Neurobiol Aging. 2012 Feb; 33(2):427.e1-14. PMID: 21144620.
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    7. Boger HA, Mannangatti P, Samuvel DJ, Saylor AJ, Bender TS, McGinty JF, Fortress AM, Zaman V, Huang P, Middaugh LD, Randall PK, Jayanthi LD, Rohrer B, Helke KL, Granholm AC, Ramamoorthy S. Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging. Genes Brain Behav. 2011 Mar; 10(2):186-98. PMID: 20860702.
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    8. Griffin WC, Novak AJ, Middaugh LD, Patrick KS. The interactive effects of methylphenidate and ethanol on ethanol consumption and locomotor activity in mice. Pharmacol Biochem Behav. 2010 May; 95(3):267-72. PMID: 20122954.
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    9. Boger HA, Granholm AC, McGinty JF, Middaugh LD. A dual-hit animal model for age-related parkinsonism. Prog Neurobiol. 2010 Feb 09; 90(2):217-29. PMID: 19853012.
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    10. Boger HA, Middaugh LD, Granholm AC, McGinty JF. Minocycline restores striatal tyrosine hydroxylase in GDNF heterozygous mice but not in methamphetamine-treated mice. Neurobiol Dis. 2009 Mar; 33(3):459-66. PMID: 19110059.
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    11. Zaman V, Boger HA, Granholm AC, Rohrer B, Moore A, Buhusi M, Gerhardt GA, Hoffer BJ, Middaugh LD. The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior. Eur J Neurosci. 2008 Oct; 28(8):1557-68. PMID: 18973577.
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    12. Boger HA, Middaugh LD, Zaman V, Hoffer B, Granholm AC. Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor, GFR alpha1, gene. Brain Res. 2008 Nov 19; 1241:18-28. PMID: 18822276.
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    13. Griffin WC, Lopez MF, Yanke AB, Middaugh LD, Becker HC. Repeated cycles of chronic intermittent ethanol exposure in mice increases voluntary ethanol drinking and ethanol concentrations in the nucleus accumbens. Psychopharmacology (Berl). 2009 Jan; 201(4):569-80. PMID: 18791704.
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    14. Boger HA, Middaugh LD, Patrick KS, Ramamoorthy S, Denehy ED, Zhu H, Pacchioni AM, Granholm AC, McGinty JF. Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice. J Neurosci. 2007 Aug 15; 27(33):8816-25. PMID: 17699663.
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    15. Griffin WC, Randall PK, Middaugh LD. Intravenous cocaine self-administration: individual differences in male and female C57BL/6J mice. Pharmacol Biochem Behav. 2007 Jun-Jul; 87(2):267-79. PMID: 17561241.
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    16. Cook-Easterwood J, Middaugh LD, Griffin WC, Khan I, Tyor WR. Highly active antiretroviral therapy of cognitive dysfunction and neuronal abnormalities in SCID mice with HIV encephalitis. Exp Neurol. 2007 Jun; 205(2):506-12. PMID: 17442303.
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    17. Nguyen SA, Malcolm R, Middaugh LD. Topiramate reduces ethanol consumption by C57BL/6 mice. Synapse. 2007 Mar; 61(3):150-6. PMID: 17146766.
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    18. Williard RL, Middaugh LD, Zhu HJ, Patrick KS. Methylphenidate and its ethanol transesterification metabolite ethylphenidate: brain disposition, monoamine transporters and motor activity. Behav Pharmacol. 2007 Feb; 18(1):39-51. PMID: 17218796.
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    19. Griffin WC, Middaugh LD, Becker HC. Voluntary ethanol drinking in mice and ethanol concentrations in the nucleus accumbens. Brain Res. 2007 Mar 23; 1138:208-13. PMID: 17275791.
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    20. Griffin WC, Middaugh LD, Tyor WR. Chronic cocaine exposure in the SCID mouse model of HIV encephalitis. Brain Res. 2007 Feb 23; 1134(1):214-9. PMID: 17189621.
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    21. Melendez RI, Middaugh LD, Kalivas PW. Development of an alcohol deprivation and escalation effect in C57BL/6J mice. Alcohol Clin Exp Res. 2006 Dec; 30(12):2017-25. PMID: 17117967.
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    22. Boger HA, Middaugh LD, Huang P, Zaman V, Smith AC, Hoffer BJ, Tomac AC, Granholm AC. A partial GDNF depletion leads to earlier age-related deterioration of motor function and tyrosine hydroxylase expression in the substantia nigra. Exp Neurol. 2006 Dec; 202(2):336-47. PMID: 16889771.
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    23. Lominac KD, Kapasova Z, Hannun RA, Patterson C, Middaugh LD, Szumlinski KK. Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties. Drug Alcohol Depend. 2006 Nov 08; 85(2):142-56. PMID: 16697125.
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    24. Zhu HJ, Wang JS, DeVane CL, Williard RL, Donovan JL, Middaugh LD, Gibson BB, Patrick KS, Markowitz JS. The role of the polymorphic efflux transporter P-glycoprotein on the brain accumulation of d-methylphenidate and d-amphetamine. Drug Metab Dispos. 2006 Jul; 34(7):1116-21. PMID: 16621932.
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    25. Wiren KM, Hashimoto JG, Alele PE, Devaud LL, Price KL, Middaugh LD, Grant KA, Finn DA. Impact of sex: determination of alcohol neuroadaptation and reinforcement. Alcohol Clin Exp Res. 2006 Feb; 30(2):233-42. PMID: 16441272.
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    26. Griffin WC, Middaugh LD. The influence of sex on extracellular dopamine and locomotor activity in C57BL/6J mice before and after acute cocaine challenge. Synapse. 2006 Feb; 59(2):74-81. PMID: 16270301.
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    27. Griffin WC, Boger HA, Granholm AC, Middaugh LD. Partial deletion of glial cell line-derived neurotrophic factor (GDNF) in mice: Effects on sucrose reward and striatal GDNF concentrations. Brain Res. 2006 Jan 12; 1068(1):257-60. PMID: 16364262.
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    28. Szumlinski KK, Lominac KD, Oleson EB, Walker JK, Mason A, Dehoff MH, Klugmann M, Klugman M, Cagle S, Welt K, During M, Worley PF, Middaugh LD, Kalivas PW. Homer2 is necessary for EtOH-induced neuroplasticity. J Neurosci. 2005 Jul 27; 25(30):7054-61. PMID: 16049182.
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    29. Szumlinski KK, Lominac KD, Frys KA, Middaugh LD. Genetic variation in heroin-induced changes in behaviour: effects of B6 strain dose on conditioned reward and locomotor sensitization in 129-B6 hybrid mice. Genes Brain Behav. 2005 Jul; 4(5):324-36. PMID: 16011579.
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    30. Nguyen SA, Deleon CP, Malcolm RJ, Middaugh LD. Tiagabine reduces ethanol reward in C57BL/6 mice under acute and chronic administration regimens. Synapse. 2005 Jun 01; 56(3):135-46. PMID: 15765538.
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    31. Cook JE, Dasgupta S, Middaugh LD, Terry EC, Gorry PR, Wesselingh SL, Tyor WR. Highly active antiretroviral therapy and human immunodeficiency virus encephalitis. Ann Neurol. 2005 Jun; 57(6):795-803. PMID: 15852478.
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    32. Patrick KS, Williard RL, VanWert AL, Dowd JJ, Oatis JE, Middaugh LD. Synthesis and pharmacology of ethylphenidate enantiomers: the human transesterification metabolite of methylphenidate and ethanol. J Med Chem. 2005 Apr 21; 48(8):2876-81. PMID: 15828826.
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    33. Price KL, Middaugh LD. The dopamine D1 antagonist reduces ethanol reward for C57BL/6 mice. Alcohol Clin Exp Res. 2004 Nov; 28(11):1666-75. PMID: 15547453.
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    34. Szumlinski KK, Dehoff MH, Kang SH, Frys KA, Lominac KD, Klugmann M, Rohrer J, Griffin W, Toda S, Champtiaux NP, Berry T, Tu JC, Shealy SE, During MJ, Middaugh LD, Worley PF, Kalivas PW. Homer proteins regulate sensitivity to cocaine. Neuron. 2004 Aug 05; 43(3):401-13. PMID: 15294147.
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    35. Becker HC, Crissman AM, Studders S, Kelley BM, Middaugh LD. Differential neurosensitivity to the discriminative stimulus properties of ethanol in C57BL/6J and C3H/He mice. Alcohol Clin Exp Res. 2004 May; 28(5):712-9. PMID: 15166645.
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    36. Griffin WC, Middaugh LD, Cook JE, Tyor WR. The severe combined immunodeficient (SCID) mouse model of human immunodeficiency virus encephalitis: deficits in cognitive function. J Neurovirol. 2004 Apr; 10(2):109-15. PMID: 15204929.
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    37. Middaugh LD, Szumlinski KK, Van Patten Y, Marlowe AL, Kalivas PW. Chronic ethanol consumption by C57BL/6 mice promotes tolerance to its interoceptive cues and increases extracellular dopamine, an effect blocked by naltrexone. Alcohol Clin Exp Res. 2003 Dec; 27(12):1892-900. PMID: 14691376.
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    38. Griffin WC, Middaugh LD. Acquisition of lever pressing for cocaine in C57BL/6J mice: effects of prior Pavlovian conditioning. Pharmacol Biochem Behav. 2003 Dec; 76(3-4):543-9. PMID: 14643854.
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    39. Szumlinski KK, Toda S, Middaugh LD, Worley PF, Kalivas PW. Evidence for a relationship between Group 1 mGluR hypofunction and increased cocaine and ethanol sensitivity in Homer2 null mutant mice. Ann N Y Acad Sci. 2003 Nov; 1003:468-71. PMID: 14684491.
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    40. Middaugh LD, Dow-Edwards D, Li AA, Sandler JD, Seed J, Sheets LP, Shuey DL, Slikker W, Weisenburger WP, Wise LD, Selwyn MR. Neurobehavioral assessment: a survey of use and value in safety assessment studies. Toxicol Sci. 2003 Dec; 76(2):250-61. PMID: 12915715.
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    41. Fuchs RA, See RE, Middaugh LD. Conditioned stimulus-induced reinstatement of extinguished cocaine seeking in C57BL/6 mice: a mouse model of drug relapse. Brain Res. 2003 May 23; 973(1):99-106. PMID: 12729958.
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    42. Zaman V, Li Z, Middaugh L, Ramamoorthy S, Rohrer B, Nelson ME, Tomac AC, Hoffer BJ, Gerhardt GA, Granholm AC. The Noradrenergic System of Aged GDNF Heterozygous Mice. Cell Transplant. 2003 Apr; 12(3):291-303. PMID: 28853928.
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    43. Zaman V, Li Z, Middaugh L, Ramamoorthy S, Rohrer B, Nelson ME, Tomac AC, Hoffer BJ, Gerhardt GA, Granholm ACh. The noradrenergic system of aged GDNF heterozygous mice. Cell Transplant. 2003; 12(3):291-303. PMID: 12797383.
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    44. Szumlinski KK, Price KL, Frys KA, Middaugh LD. Unconditioned and conditioned factors contribute to the 'reinstatement' of cocaine place conditioning following extinction in C57BL/6 mice. Behav Brain Res. 2002 Oct 17; 136(1):151-60. PMID: 12385800.
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    45. Middaugh LD, Bandy AL. Naltrexone effects on ethanol consumption and response to ethanol conditioned cues in C57BL/6 mice. Psychopharmacology (Berl). 2000 Sep; 151(4):321-7. PMID: 11026738.
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    46. Middaugh LD, Lee AM, Bandy AL. Ethanol reinforcement in nondeprived mice: effects of abstinence and naltrexone. Alcohol Clin Exp Res. 2000 Aug; 24(8):1172-9. PMID: 10968654.
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    47. Middaugh LD, Kelley BM, Groseclose CH, Cuison ER. Delta-opioid and 5-HT3 receptor antagonist effects on ethanol reward and discrimination in C57BL/6 mice. Pharmacol Biochem Behav. 2000 Jan 01; 65(1):145-54. PMID: 10638648.
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    48. Tyor WR, Middaugh LD. Do alcohol and cocaine abuse alter the course of HIV-associated dementia complex? J Leukoc Biol. 1999 Apr; 65(4):475-81. PMID: 10204576.
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    49. Middaugh LD, Kelley BM, Bandy AL, McGroarty KK. Ethanol consumption by C57BL/6 mice: influence of gender and procedural variables. Alcohol. 1999 Apr; 17(3):175-83. PMID: 10231165.
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    50. Middaugh LD, Kelley BM. Operant ethanol reward in C57BL/6 mice: influence of gender and procedural variables. Alcohol. 1999 Apr; 17(3):185-94. PMID: 10231166.
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    51. Nocjar C, Middaugh LD, Tavernetti M. Ethanol consumption and place-preference conditioning in the alcohol-preferring C57BL/6 mouse: relationship with motor activity patterns. Alcohol Clin Exp Res. 1999 Apr; 23(4):683-92. PMID: 10235304.
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    52. Middaugh LD, Kelley BM, Cuison ER, Groseclose CH. Naltrexone effects on ethanol reward and discrimination in C57BL/6 mice. Alcohol Clin Exp Res. 1999 Mar; 23(3):456-64. PMID: 10195818.
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    53. Kelley BM, Middaugh LD. Periadolescent nicotine exposure reduces cocaine reward in adult mice. J Addict Dis. 1999; 18(3):27-39. PMID: 10507580.
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    54. Avgeropoulos N, Kelley B, Middaugh L, Arrigo S, Persidsky Y, Gendelman HE, Tyor WR. SCID mice with HIV encephalitis develop behavioral abnormalities. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 May 01; 18(1):13-20. PMID: 9593453.
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    55. Middaugh LD, McGroarty KK, Groseclose CH, Adinoff B. Cocaine discrimination: relationship to local anesthetics and monoamine uptake inhibitors in C57BL/6 mice. Psychopharmacology (Berl). 1998 Mar; 136(1):44-9. PMID: 9537681.
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    56. Groseclose CH, Draughn RA, Tyor WR, Sallee FR, Middaugh LD. Long-term intracranial cannula stabilization in mice with light cured resin composites. J Neurosci Methods. 1998 Jan 31; 79(1):31-6. PMID: 9531457.
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    57. Kelley BM, Bandy AL, Middaugh LD. A study examining intravenous ethanol-conditioned place preference in C57BL/6J mice. Alcohol Clin Exp Res. 1997 Dec; 21(9):1661-6. PMID: 9438527.
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    58. Kelley BM, Groseclose CH, Middaugh LD. Prenatal cocaine exposure increases the reinforcing strength of oral ethanol in C57 mice. Neurotoxicol Teratol. 1997 Sep-Oct; 19(5):391-8. PMID: 9380006.
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    59. Altman-Hamamdzic S, Groseclose C, Ma JX, Hamamdzic D, Vrindavanam NS, Middaugh LD, Parratto NP, Sallee FR. Expression of beta-galactosidase in mouse brain: utilization of a novel nonreplicative Sindbis virus vector as a neuronal gene delivery system. Gene Ther. 1997 Aug; 4(8):815-22. PMID: 9338010.
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    60. Kelley BM, Bandy AL, Middaugh LD. A novel chronic and detachable indwelling jugular catheterization procedure for mice. Physiol Behav. 1997 Jul; 62(1):163-7. PMID: 9226357.
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    61. Xu W, Bai F, Tummalapalli CM, Miller DD, Middaugh L, Boggan WO. The interactive effects of cocaine/gender on immune function in mice. An observation of in vivo acute cocaine exposure. Int J Immunopharmacol. 1997 Jun; 19(6):333-40. PMID: 9467752.
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    62. Halberda JP, Middaugh LD, Gard BE, Jackson BP. DAD1- and DAD2-like agonist effects on motor activity of C57 mice: differences compared to rats. Synapse. 1997 May; 26(1):81-92. PMID: 9097408.
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    63. Groseclose CH, Middaugh LD. The discrimination and durability of an ethanol cue in young and mid-aged female mice. Alcohol. 1997 Mar-Apr; 14(2):191-7. PMID: 9085721.
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    64. Middaugh LD, Boggan WO, Bingel SA, Patrick KS, Xu W. A murine model of prenatal cocaine exposure: effects on the mother and the fetus. Pharmacol Biochem Behav. 1996 Dec; 55(4):565-74. PMID: 8981587.
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    65. Kelley BM, Middaugh LD. Ethanol self-administration and motor deficits in adults C57BL/6J mice exposed prenatally to cocaine. Pharmacol Biochem Behav. 1996 Dec; 55(4):575-84. PMID: 8981588.
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    66. Miller SR, Middaugh LD, Boggan WO, Patrick KS. Cocaine concentrations in fetal C57BL/6 mouse brain relative to maternal brain and plasma. Neurotoxicol Teratol. 1996 Nov-Dec; 18(6):645-9. PMID: 8947941.
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    67. Middaugh LD, Nussbaum R, Ludwicka A, Bolster MB, Silver RM. Cognitive deficits in a murine model of the eosinophilia-myalgia syndrome: a preliminary report. Neurotoxicol Teratol. 1996 Sep-Oct; 18(5):595-601. PMID: 8888024.
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    68. Xu W, Tyor WR, Middaugh LD, Boggan WO. Cocaine/sex type effects on T lymphocytes: a preliminary report. Drug Chem Toxicol. 1996; 19(1-2):109-19. PMID: 8804556.
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    69. Boggan WO, Xu W, Shepherd CL, Middaugh LD. Effects of prenatal ethanol exposure on dopamine systems in C57BL/6J mice. Neurotoxicol Teratol. 1996 Jan-Feb; 18(1):41-8. PMID: 8700042.
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    70. Gentry GD, Merritt CJ, Middaugh LD. Effects of prenatal maternal ethanol on male offspring progressive-ratio performance and response to amphetamine. Neurotoxicol Teratol. 1995 Nov-Dec; 17(6):673-7. PMID: 8747749.
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    71. Middaugh LD, Boggan WO. Perinatal maternal ethanol effects on pregnant mice and on offspring viability and growth: influences of exposure time and weaning diet. Alcohol Clin Exp Res. 1995 Oct; 19(5):1351-8. PMID: 8561314.
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    72. Middaugh LD, Boggan WO, Shepherd CL. Prenatal ethanol effects and dopamine systems of adult C57 male mice. Neurotoxicol Teratol. 1994 Mar-Apr; 16(2):207-12. PMID: 7914346.
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    73. Patrick KS, Boggan WO, Miller SR, Middaugh LD. Gas chromatographic-mass spectrometric determination of plasma and brain cocaine in mice. J Chromatogr. 1993 Nov 17; 621(1):89-94. PMID: 8308092.
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    74. Middaugh LD, Bao K, Shepherd CL. Comparative effects of ethanol on motor activity and operant behavior. Pharmacol Biochem Behav. 1992 Oct; 43(2):625-9. PMID: 1438501.
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    75. Middaugh LD, Gentry GD. Prenatal ethanol effects on reward efficacy for adult mice are gestation stage specific. Neurotoxicol Teratol. 1992 Sep-Oct; 14(5):365-70. PMID: 1454046.
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    76. Hale RL, Randall CL, Becker HC, Middaugh LD. The effect of prenatal ethanol exposure on scentmarking in the C57BL/6J and C3H/He mouse strains. Alcohol. 1992 Jul-Aug; 9(4):287-92. PMID: 1637494.
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    77. Bao K, Middaugh LD, Becker HC, Shepherd CL. Effects of Ro 15-4513 and ethanol on operant behavior of male and female C57BL/6 mice. Alcohol. 1992 May-Jun; 9(3):193-8. PMID: 1605885.
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    78. Middaugh LD, Frackelton WF, Boggan WO, Onofrio A, Shepherd CL. Gender differences in the effects of ethanol on C57BL/6 mice. Alcohol. 1992 May-Jun; 9(3):257-60. PMID: 1605893.
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    79. Middaugh LD, Boggan WO. Postnatal growth deficits in prenatal ethanol-exposed mice: characteristics and critical periods. Alcohol Clin Exp Res. 1991 Dec; 15(6):919-26. PMID: 1789388.
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    80. Middaugh LD, Bao K, Becker HC, Daniel SS. Effects of Ro 15-4513 on ethanol discrimination in C57BL/6 mice. Pharmacol Biochem Behav. 1991 Apr; 38(4):763-7. PMID: 1651516.
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    81. Adams J, Vorhees CV, Middaugh LD. Developmental neurotoxicity of anticonvulsants: human and animal evidence on phenytoin. Neurotoxicol Teratol. 1990 May-Jun; 12(3):203-14. PMID: 2196420.
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    82. Middaugh LD, Favara JP, Boggan WO. Ethanol stimulation after chronic exposure in C57 mice. Pharmacol Biochem Behav. 1989 Oct; 34(2):331-5. PMID: 2622989.
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    83. Boggan W, Middaugh L. Effect of central injection of phencyclidine on QNB accumulation and motor activity. Eur J Pharmacol. 1989 Jul 18; 166(2):123-9. PMID: 2792187.
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    84. Boggan WO, Middaugh LD, Faught K. Effect of dopaminergic drugs on enhancement of the binding of quinuclidinyl benzilate by phencyclidine in vivo. Neuropharmacology. 1989 Jun; 28(6):617-24. PMID: 2569176.
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    85. Boggan WO, Monroe B, Turner WR, Upshur J, Middaugh LD. Effect of prenatal ethanol administration on the urogenital system of mice. Alcohol Clin Exp Res. 1989 Apr; 13(2):206-8. PMID: 2658657.
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    86. Middaugh LD. Prenatal amphetamine effects on behavior: possible mediation by brain monoamines. Ann N Y Acad Sci. 1989; 562:308-18. PMID: 2662861.
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    87. Middaugh LD, Ayers KL. Effects of ethanol on mature offspring of mice given ethanol during pregnancy. Alcohol Clin Exp Res. 1988 Jun; 12(3):388-93. PMID: 3044168.
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    88. Boggan WO, Faught K, Boyd S, Middaugh LD. Parametric studies on phencyclidine enhancement of 3H quinuclidinyl benzilate accumulation in vivo. Pharmacol Biochem Behav. 1988 May; 30(1):31-5. PMID: 3174753.
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    89. Middaugh LD, Randall CL, Favara JP. Prenatal ethanol exposure in C57 mice: effects on pregnancy and offspring development. Neurotoxicol Teratol. 1988 Mar-Apr; 10(2):175-80. PMID: 3398826.
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    90. Gentry GD, Middaugh LD. Prenatal ethanol weakens the efficacy of reinforcers for adult mice. Teratology. 1988 Feb; 37(2):135-44. PMID: 3353863.
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    91. Middaugh LD, Favara JP, Boggan WO, Stringer AJ. Discriminative properties of phencyclidine in mice: generalization to ketamine and monohydroxy metabolites. Psychopharmacology (Berl). 1988; 96(3):381-4. PMID: 3146772.
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    92. Frackelton WH, Middaugh LD. Automated acquisition and analysis of animal behavior data utilizing an Apple IIe. Physiol Behav. 1988; 43(2):253-7. PMID: 3212066.
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    93. Buckholtz NS, Middaugh LD. Effects of caffeine and L-phenylisopropyladenosine on locomotor activity of mice. Pharmacol Biochem Behav. 1987 Oct; 28(2):179-85. PMID: 3685054.
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    94. Middaugh LD, Boggan WO, Randall CL. Stimulatory effects of ethanol in C57BL/6 mice. Pharmacol Biochem Behav. 1987 Jul; 27(3):421-4. PMID: 3659065.
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    95. Boggan WO, Stringer AJ, Faught K, Middaugh LD. Effect of phencyclidine and two monohydroxy metabolites on 3H QNB binding in vivo in rats. Pharmacol Biochem Behav. 1987 Apr; 26(4):847-9. PMID: 3602041.
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    96. Boggan WO, Middaugh LD. Doubtful role for phencyclidine metabolites in PCP enhancement of QNB binding. Pharmacol Biochem Behav. 1987 Apr; 26(4):671-6. PMID: 3602029.
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    97. Middaugh LD. Phenobarbital during pregnancy in mouse and man. Neurotoxicology. 1986; 7(2):287-301. PMID: 3785754.
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    98. Middaugh LD, Zemp JW. Dopaminergic mediation of long-term behavioral effects of in utero drug exposure. Neurobehav Toxicol Teratol. 1985 Nov-Dec; 7(6):685-9. PMID: 3835467.
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    99. Randall CL, Becker HC, Middaugh LD. Effect of prenatal ethanol exposure on activity and shuttle avoidance behavior in adult C57 mice. Alcohol Drug Res. 1985-1986; 6(5):351-60. PMID: 3834928.
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    100. Middaugh LD, Zemp JW, Boggan WO. Pregnancy increases reactivity of mice to phenobarbital. Science. 1983 Apr 29; 220(4596):534-6. PMID: 6836299.
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    101. Middaugh LD, Kapetanovic IM, Sweeney DJ, Ingram DK. Methadone in brain and its effects on locomotor activity of young and aged mice. Neurobiol Aging. 1983; 4(4):321-6. PMID: 6672639.
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    102. Middaugh LD, Ingram DK, Reynolds MA. Methadone effects on locomotor activity of young and aged mice. Neurobiol Aging. 1983; 4(2):157-61. PMID: 6633785.
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    103. Middaugh LD, Blackwell LA, Boggan WO, Zemp JW. Brain concentrations of phenobarbital and behavioral activation or depression. Pharmacol Biochem Behav. 1981 Nov; 15(5):723-8. PMID: 7312908.
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    104. Middaugh LD, Simpson LW, Thomas TN, Zemp JW. Prenatal maternal phenobarbital increases reactivity and retards habituation of mature offspring to environmental stimuli. Psychopharmacology (Berl). 1981; 74(4):349-52. PMID: 6794080.
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    105. Middaugh LD, Thomas TN, Simpson LW, Zemp JW. Effects of prenatal maternal injections of phenobarbital on brain neurotransmitters and behavior of young C57 mice. Neurobehav Toxicol Teratol. 1981; 3(3):271-5. PMID: 6117021.
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    106. Tolbert LC, Thomas TN, Middaugh LD, Zemp JW. Effect of ascorbic acid on neurochemical, behavioral, and physiological systems mediated by catecholamines. Life Sci. 1979 Dec 24; 25(26):2189-95. PMID: 542096.
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    107. Boggan WO, Meyer JS, Middaugh LD, Sparks DL. Ethanol, calcium, and naloxone in mice. Alcohol Clin Exp Res. 1979 Apr; 3(2):158-61. PMID: 391077.
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    108. Middaugh LD, Boggan WO, Wilson-Burrows C, Zemp JW. Prenatal maternal phenobarbital alters plasma concentrations of corticosterone in developing offspring. Life Sci. 1979 Mar 12; 24(11):999-1002. PMID: 571948.
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    109. Tolbert LC, Thomas TN, Middaugh LD, Zemp JW. Ascorbate blocks amphetamine-induced turning behavior in rats with unilateral nigro-striatal lesions. Brain Res Bull. 1979 Jan-Feb; 4(1):43-8. PMID: 572739.
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    110. Middaugh LD, Read E, Boggan WO. Effects of naloxone on ethanol induced alterations of locomotor activity in C57BL/6 mice. Pharmacol Biochem Behav. 1978 Aug; 9(2):157-60. PMID: 714965.
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    111. Middaugh LD, Santos CA. Effects of methadone on behavior maintained by fixed ratio reinforcement schedules. Pharmacol Biochem Behav. 1978 May; 8(5):521-6. PMID: 674258.
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    112. Middaugh LD, Zemp JW. Effects of methadone on activity and on brain monoamines in two strains of mice. Pharmacol Biochem Behav. 1976 Sep; 5(3):367-70. PMID: 996068.
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    113. Middaugh LD, Grover TA, Blackwell LA, Zemp JW. Neurochemical and behavioral effects of diet related perinatal folic acid restriction. Pharmacol Biochem Behav. 1976 Aug; 5(2):129-34. PMID: 996047.
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    114. Middaugh LD, Santos CA, Zemp JW. Phenobarbital during pregnancy alters operant behavior of offspring in C57BL/6J mice. Pharmacol Biochem Behav. 1975 Nov-Dec; 3(6):1137-9. PMID: 1223902.
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    115. Middaugh LD, Santos CA, Zemp JW. Effects of phenobarbital given to pregnant mice on behavior of mature offspring. Dev Psychobiol. 1975 Jul; 8(4):305-13. PMID: 1225697.
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    116. Zemp JW, Middaugh LD. Some effects of prenatal exposure to d-amphetamine sulfate and phenobarbital on developmental neurochemistry and on behavior. Addict Dis. 1975; 2(1-2):307-31. PMID: 1163369.
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    117. Middaugh LD, Blackwell LA, Santos CA, Zemp JW. Effects of d-amphetamine sulfate given to pregnant mice on activity and on catecholamines in the brains of offspring. Dev Psychobiol. 1974 Sep; 7(5):429-38. PMID: 4426470.
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    118. Lubar JF, Middaugh LD. Avoidance conditioning in cats with striate and auditory cortex lesions and contrasting effects of peripheral blindness. J Comp Physiol Psychol. 1971 Jul; 76(1):26-30. PMID: 5559604.
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