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Lauren Elizabeth Ball

Title
InstitutionMedical University of South Carolina
DepartmentCell and Molecular Pharmacology and Experimental Therapeutics
AddressP.O. Box MSC 509
CRI311
173 Ashley Ave.
Phone843-792-4513
Fax843-792-2475
ORCID ORCID Icon0000-0001-6780-1679 Additional info
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    Collapse Biography 
    Collapse education and training
    University of the South, Sewanee, TNBS05/1994Biochemistry
    Medical University of South Carolina, Charleston, SCPhD05/2003Pharmacology
    Medical University of South Carolina, Charleston, SCPost-Doctoral08/2006Endocrinology

    Collapse Overview 
    Collapse keywords
    Insulin Signaling; Insulin Receptor Substrates; IGF-1 Signaling; Mass Spectrometry; LC-MS/MS; Proteomics; O-GlcNAc Modification; O-GlcNAc Transferase; Phosphoproteomics; Orbitrap; Post-translational Modifications; Redox Signaling; Insulin Resistance; Diabetic Complications; Cancer

    Collapse Research 
    Collapse research activities and funding
    T32HL007260     (MENICK, DONALD R.)Jul 1, 1977 - Jun 30, 2022
    NIH
    Training To Improve Cardiovascular Therapies
    Role Description: The goal of this study was to evaluate the role of O-GlcNAc Transferase (OGT), O-GlcNAcase (OGA), and protein O-GlcNAc modification in the development of diabetic complications.
    Role: Post-Doctoral Fellow, 2003-2004

    R01DK002001     (BUSE, MARIA G)May 1, 1978 - Feb 28, 2014
    NIH
    Factors that modify insulin action
    Role Description: The goal of Aim 2 (2009-2014) led by Dr. Ball is to test the hypothesis that O-GlcNAc modification of IRS1 attenuates hepatic insulin signaling.
    Role: Co-Investigator, 2009-2014

    9732152     (CROUCH, ROSALIE K)Jun 16, 1998 - May 31, 2000
    NSF Div of Biol Infrastructure
    REU Site in Cellular Signal Transduction
    Role Description: The goal of this study was to detect age-related post-translational modifications of an integral membrane water channel, Aquaporin 0, by LC-MS/MS during the course of aging and cataract development.
    Role: Pre-Doctoral Fellow, 1998-2000

    R01DK055524     (LUTTRELL, LOUIS M)Sep 25, 1998 - Apr 30, 2018
    NIH
    Tyrosine Kinases in G Protein Mediated Signaling
    Role: Co-Investigator, 2014-2018

    P20RR017696     (KIRKWOOD, KEITH L)Sep 30, 2002 - Jul 31, 2013
    NIH
    South Carolina COBRE for Oral Health Research
    Role Description: The goal of this study is to detect and functionally evaluate the role of glucose-induced O-GlcNAc modification of insulin receptor substrate (IRS1) in diabetic complications including alveolar bone loss.
    Role: Sub-Project PI, 2008-2010

    5U24DE016508-02     (SLATE, ELIZABETH H)Sep 27, 2004 - Aug 31, 2008
    NIH
    Oral Health Research Infrastructure Development at MUSC
    Role Description: Start up funds for faculty recruitment.
    Role: Recruited Faculty, 2006

    3-2005-337     (BALL, LAUREN E)Jun 1, 2005 - Sep 1, 2006
    Juvenile Diabetes Research Foundation
    Role of the Hexosamine Pathway in Vascular Complications of Diabetes.
    Role Description: Post-Doctoral Fellowship
    Role: Principal Investigator

    W81XWH-07-1-0691     (EBLEN, SCOTT T)Jun 1, 2006 - May 31, 2010
    DOD/US ARMY
    Regulation of Senescence by p38 MAP Kinase in ErbB-2-Induced Breast Cancer
    Role: Co-Investigator

    IRG-97-219-08     (REED, CAROLYN E)Jan 1, 2007 - Dec 31, 2008
    American Cancer Society
    Regulation of Growth Factor Signaling by O-GlcNAc Glycosylation
    Role: Pilot Project PI, 2007-2008

    R01DK073336     (LEMASTERS, JOHN J)Mar 20, 2007 - Aug 31, 2018
    NIH
    Mechanisms of I/R Injury to Hepatocytes
    Role: Co-Investigator, 2014-2016

    R01DE020925     (BALL, LAUREN ELIZABETH)Jul 1, 2010 - Jun 30, 2015
    NIH
    Regulation of IGF-1 and Insulin Signaling by O-GlcNAc Glycosylation
    Role: Principal Investigator

    P20GM103542     (TEW, KENNETH D.)Sep 1, 2011 - Jul 31, 2021
    NIH
    South Carolina COBRE in Oxidants, Redox Balance and Stress Signaling
    Role Description: The goal of the Proteomics Core is to assist COBRE-funded junior investigators investigate signaling mechanisms underlying disease onset/progression; drug effects and resistance; and cellular/systemic metabolic regulation using LC-MS/MS-based quantitative proteomics.
    Role: Director, Mass Spectrometry Facility and Proteomics Core

    S10OD010731     (BALL, LAUREN ELIZABETH)May 1, 2012 - Apr 30, 2013
    NIH
    Orbitrap Mass Spectrometer
    Role: Principal Investigator

    R21DE025920     (PALANISAMY, VISWANATHAN)Jan 1, 2017 - Dec 31, 2018
    NIH
    Comprehensive Identification of FXR1 Targets Using pSILAC-BONCAT Proteomics
    Role: Co-Investigator

    R35GM126955     (LUTTRELL, LOUIS M)May 1, 2018 - Apr 30, 2023
    NIH
    Pharmacodynamics of Biased G Protein-Coupled Receptor Agonism
    Role: Co-Investigator

    S10OD025126     (BALL, LAUREN ELIZABETH)Aug 3, 2018 - Aug 2, 2019
    NIH
    Orbitrap Fusion Lumos ETD Mass Spectrometer
    Role Description: ThermoScientific Orbitrap Fusion Lumos Mass Spectrometer with ETD and UVPD. High End Shared Instrumentation Grant ($991,000) to purchase state-of-the-art LC-MS/MS-based proteomics instrumentation for the MUSC Mass Spectrometry Facility.
    Role: Principal Investigator

    R01AI138511     (VASU, CHENTHAMARAKSHAN)Nov 6, 2018 - Oct 31, 2023
    NIH
    Role of microbiota-TLR7/8 Interaction in systemic lupus erythematosus
    Role: Co-Investigator

    R21CA240148     (ANGEL, PEGGY M)Aug 1, 2019 - Jul 31, 2021
    NIH
    Enzymatic Tools for 2D Tissue Localized and Deeper Proteomic Sequencing of Cancer Stromal Proteins
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kruyer A, Ball LE, Townsend DM, Kalivas PW, Uys JD. Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking. PLoS One. 2019; 14(9):e0223037. PMID: 31550273.
      View in: PubMed
    2. Zhang L, Zhang J, Ye Z, Manevich Y, Ball LE, Bethard JR, Jiang YL, Broome AM, Dalton AC, Wang GY, Townsend DM, Tew KD. Isoflavone ME-344 disrupts redox homeostasis and mitochondrial function by targeting Heme Oxygenase 1. Cancer Res. 2019 Jun 21. PMID: 31227482.
      View in: PubMed
    3. Chakraborty P, Chatterjee S, Kesarwani P, Thyagarajan K, Iamsawat S, Dalheim A, Nguyen H, Selvam SP, Nasarre P, Scurti G, Hardiman G, Maulik N, Ball L, Gangaraju V, Rubinstein MP, Klauber-DeMore N, Hill EG, Ogretmen B, Yu XZ, Nishimura MI, Mehrotra S. Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells. J Biol Chem. 2019 Jun 07; 294(23):9198-9212. PMID: 30971427.
      View in: PubMed
    4. Liu B, Salgado OC, Singh S, Hippen KL, Maynard JC, Burlingame AL, Ball LE, Blazar BR, Farrar MA, Hogquist KA, Ruan HB. The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation. Nat Commun. 2019 01 21; 10(1):354. PMID: 30664665.
      View in: PubMed
    5. Angel PM, Schwamborn K, Comte-Walters S, Clift CL, Ball LE, Mehta AS, Drake RR. Extracellular Matrix Imaging of Breast Tissue Pathologies by MALDI-Imaging Mass Spectrometry. Proteomics Clin Appl. 2019 01; 13(1):e1700152. PMID: 30251340.
      View in: PubMed
    6. Zhang J, Ye ZW, Chen W, Manevich Y, Mehrotra S, Ball L, Janssen-Heininger Y, Tew KD, Townsend DM. S-Glutathionylation of estrogen receptor a affects dendritic cell function. J Biol Chem. 2018 03 23; 293(12):4366-4380. PMID: 29374060.
      View in: PubMed
    7. Angel PM, Comte-Walters S, Ball LE, Talbot K, Mehta A, Brockbank KGM, Drake RR. Mapping Extracellular Matrix Proteins in Formalin-Fixed, Paraffin-Embedded Tissues by MALDI Imaging Mass Spectrometry. J Proteome Res. 2018 01 05; 17(1):635-646. PMID: 29161047.
      View in: PubMed
    8. Herr DJ, Baarine M, Aune SE, Li X, Ball LE, Lemasters JJ, Beeson CC, Chou JC, Menick DR. HDAC1 localizes to the mitochondria of cardiac myocytes and contributes to early cardiac reperfusion injury. J Mol Cell Cardiol. 2018 01; 114:309-319. PMID: 29224834.
      View in: PubMed
    9. Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt MW, Dhar P, Selvam SP, Fu J, Zhang J, Nguyen H, Kang I, Toth K, Al-Homrani M, Husain M, Beeson G, Ball L, Helke K, Husain S, Garrett-Mayer E, Hardiman G, Mehrotra M, Nishimura MI, Beeson CC, Bupp MG, Wu J, Ogretmen B, Paulos CM, Rathmell J, Yu XZ, Mehrotra S. CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. Cell Metab. 2018 01 09; 27(1):85-100.e8. PMID: 29129787.
      View in: PubMed
    10. Kim MJ, Vargas MR, Harlan BA, Killoy KM, Ball LE, Comte-Walters S, Gooz M, Yamamoto Y, Beckman JS, Barbeito L, Pehar M. Nitration and Glycation Turn Mature NGF into a Toxic Factor for Motor Neurons: A Role for p75NTR and RAGE Signaling in ALS. Antioxid Redox Signal. 2018 06 20; 28(18):1587-1602. PMID: 28537420.
      View in: PubMed
    11. Nimitvilai S, Uys JD, Woodward JJ, Randall PK, Ball LE, Williams RW, Jones BC, Lu L, Grant KA, Mulholland PJ. Orbitofrontal Neuroadaptations and Cross-Species Synaptic Biomarkers in Heavy-Drinking Macaques. J Neurosci. 2017 03 29; 37(13):3646-3660. PMID: 28270566.
      View in: PubMed
    12. Wang X, Yuan ZF, Fan J, Karch KR, Ball LE, Denu JM, Garcia BA. A Novel Quantitative Mass Spectrometry Platform for Determining Protein O-GlcNAcylation Dynamics. Mol Cell Proteomics. 2016 07; 15(7):2462-75. PMID: 27114449.
      View in: PubMed
    13. Song JH, Padi SK, Luevano LA, Minden MD, DeAngelo DJ, Hardiman G, Ball LE, Warfel NA, Kraft AS. Insulin receptor substrate 1 is a substrate of the Pim protein kinases. Oncotarget. 2016 Apr 12; 7(15):20152-65. PMID: 26956053.
      View in: PubMed
    14. Pehar M, Ball LE, Sharma DR, Harlan BA, Comte-Walters S, Neely BA, Vargas MR. Changes in Protein Expression and Lysine Acetylation Induced by Decreased Glutathione Levels in Astrocytes. Mol Cell Proteomics. 2016 Feb; 15(2):493-505. PMID: 26486419.
      View in: PubMed
    15. Williams GR, Bethard JR, Berkaw MN, Nagel AK, Luttrell LM, Ball LE. Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics. Methods. 2016 Jan 01; 92:36-50. PMID: 26160508.
      View in: PubMed
    16. Uys JD, McGuier NS, Gass JT, Griffin WC, Ball LE, Mulholland PJ. Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines. Addict Biol. 2016 May; 21(3):560-74. PMID: 25787124.
      View in: PubMed
    17. Nagel AK, Ball LE. Intracellular protein O-GlcNAc modification integrates nutrient status with transcriptional and metabolic regulation. Adv Cancer Res. 2015; 126:137-66. PMID: 25727147.
      View in: PubMed
    18. Drake RR, Ball L. Unique to this volume is the subsequent focus of individual chapters on what is known about glycosylation in relation to specific organ sites of cancer. Preface. Adv Cancer Res. 2015; 126:xiii-xiv. PMID: 25727154.
      View in: PubMed
    19. Nagel AK, Ball LE. O-GlcNAc modification of the runt-related transcription factor 2 (Runx2) links osteogenesis and nutrient metabolism in bone marrow mesenchymal stem cells. Mol Cell Proteomics. 2014 Dec; 13(12):3381-95. PMID: 25187572.
      View in: PubMed
    20. Nagel AK, Ball LE. O-GlcNAc transferase and O-GlcNAcase: achieving target substrate specificity. Amino Acids. 2014 Oct; 46(10):2305-16. PMID: 25173736.
      View in: PubMed
    21. Hart GW, Ball LE. Post-translational modifications: a major focus for the future of proteomics. Mol Cell Proteomics. 2013 Dec; 12(12):3443. PMID: 24277940.
      View in: PubMed
    22. Leymarie N, Griffin PJ, Jonscher K, Kolarich D, Orlando R, McComb M, Zaia J, Aguilan J, Alley WR, Altmann F, Ball LE, Basumallick L, Bazemore-Walker CR, Behnken H, Blank MA, Brown KJ, Bunz SC, Cairo CW, Cipollo JF, Daneshfar R, Desaire H, Drake RR, Go EP, Goldman R, Gruber C, Halim A, Hathout Y, Hensbergen PJ, Horn DM, Hurum D, Jabs W, Larson G, Ly M, Mann BF, Marx K, Mechref Y, Meyer B, Möginger U, Neusüß C, Nilsson J, Novotny MV, Nyalwidhe JO, Packer NH, Pompach P, Reiz B, Resemann A, Rohrer JS, Ruthenbeck A, Sanda M, Schulz JM, Schweiger-Hufnagel U, Sihlbom C, Song E, Staples GO, Suckau D, Tang H, Thaysen-Andersen M, Viner RI, An Y, Valmu L, Wada Y, Watson M, Windwarder M, Whittal R, Wuhrer M, Zhu Y, Zou C. Interlaboratory study on differential analysis of protein glycosylation by mass spectrometry: the ABRF glycoprotein research multi-institutional study 2012. Mol Cell Proteomics. 2013 Oct; 12(10):2935-51. PMID: 23764502.
      View in: PubMed
    23. Nagel AK, Schilling M, Comte-Walters S, Berkaw MN, Ball LE. Identification of O-linked N-acetylglucosamine (O-GlcNAc)-modified osteoblast proteins by electron transfer dissociation tandem mass spectrometry reveals proteins critical for bone formation. Mol Cell Proteomics. 2013 Apr; 12(4):945-55. PMID: 23443134.
      View in: PubMed
    24. Darley-Usmar VM, Ball LE, Chatham JC. Protein O-linked ß-N-acetylglucosamine: a novel effector of cardiomyocyte metabolism and function. J Mol Cell Cardiol. 2012 Mar; 52(3):538-49. PMID: 21878340.
      View in: PubMed
    25. Klein AL, Berkaw MN, Buse MG, Ball LE. O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs. Mol Cell Proteomics. 2009 Dec; 8(12):2733-45. PMID: 19671924.
      View in: PubMed
    26. Robinson KA, Ball LE, Buse MG. Reduction of O-GlcNAc protein modification does not prevent insulin resistance in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab. 2007 Mar; 292(3):E884-90. PMID: 17122093.
      View in: PubMed
    27. Ball LE, Berkaw MN, Buse MG. Identification of the major site of O-linked beta-N-acetylglucosamine modification in the C terminus of insulin receptor substrate-1. Mol Cell Proteomics. 2006 Feb; 5(2):313-23. PMID: 16244361.
      View in: PubMed
    28. Ervin LA, Ball LE, Crouch RK, Schey KL. Phosphorylation and glycosylation of bovine lens MP20. Invest Ophthalmol Vis Sci. 2005 Feb; 46(2):627-35. PMID: 15671292.
      View in: PubMed
    29. Ball LE, Garland DL, Crouch RK, Schey KL. Post-translational modifications of aquaporin 0 (AQP0) in the normal human lens: spatial and temporal occurrence. Biochemistry. 2004 Aug 03; 43(30):9856-65. PMID: 15274640.
      View in: PubMed
    30. Ball LE, Little M, Nowak MW, Garland DL, Crouch RK, Schey KL. Water permeability of C-terminally truncated aquaporin 0 (AQP0 1-243) observed in the aging human lens. Invest Ophthalmol Vis Sci. 2003 Nov; 44(11):4820-8. PMID: 14578404.
      View in: PubMed
    31. Knapp DR, Crouch RK, Ball LE, Gelasco AK, Ablonczy Z. Mass spectrometric analysis of G protein-coupled receptors. Methods Enzymol. 2002; 343:157-61. PMID: 11665563.
      View in: PubMed
    32. Ball LE, Oatis JE, Dharmasiri K, Busman M, Wang J, Cowden LB, Galijatovic A, Chen N, Crouch RK, Knapp DR. Mass spectrometric analysis of integral membrane proteins: application to complete mapping of bacteriorhodopsins and rhodopsin. Protein Sci. 1998 Mar; 7(3):758-64. PMID: 9541408.
      View in: PubMed
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