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Karen J. Hartwell

Title
InstitutionMedical University of South Carolina
DepartmentPsychiatry and Behavioral Sciences
AddressP.O. Box MSC 861
469N
Psychiatric Hospital - 67 President St.
Phone843-792-4606
Fax843-792-7353
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    Dr. Hartwell's general research interests are tobacco use disorders, smoking cessation and craving to smoke during a quit attempt. Her studies have examined the underlying neurobiology of craving using neuroimaging techniques. She is also interested in gender differences in substance use disorders. As an addiction psychiatrist she provides clinical care for substance use disorders at the Ralph H. Johnson VAMC.

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    smoking cessation, tobacco use disorders, substance use disorder treatment

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Friedrich D, Li X, Hartwell KJ, Short EB, Sahlem GL, George MS. Tolerability and feasibility of accelerated repetitive transcranial stimulation for reduction of nicotine craving. Brain Stimul. 2019 Jun 20. PMID: 31253502.
      View in: PubMed
    2. Flanagan JC, Sippel LM, Santa Maria MMM, Hartwell KJ, Brady KT, Joseph JE. Impact of Oxytocin on the neural correlates of fearful face processing in PTSD related to childhood Trauma. Eur J Psychotraumatol. 2019; 10(1):1606626. PMID: 31105906.
      View in: PubMed
    3. Moran-Santa Maria MM, Vanderweyen DC, Camp CC, Zhu X, McKee SA, Cosgrove KP, Hartwell KJ, Brady KT, Joseph JE. Network Analysis of Intrinsic Functional Brain Connectivity in Male and Female Adult Smokers: A Preliminary Study. Nicotine Tob Res. 2018 06 07; 20(7):810-818. PMID: 29059410.
      View in: PubMed
    4. Chauchard E, Hartwell KJ, McRae-Clark AL, Sherman BJ, Gorelick DA. Cannabis Withdrawal in Adults With Attention-Deficit/Hyperactivity Disorder. Prim Care Companion CNS Disord. 2018 Feb 22; 20(1). PMID: 29489073.
      View in: PubMed
    5. Li X, Sahlem GL, Badran BW, McTeague LM, Hanlon CA, Hartwell KJ, Henderson S, George MS. Transcranial magnetic stimulation of the dorsal lateral prefrontal cortex inhibits medial orbitofrontal activity in smokers. Am J Addict. 2017 Dec; 26(8):788-794. PMID: 28898485.
      View in: PubMed
    6. Zuschlag Z, Kennedy A, Korte J, Franko-Tobin L, Hartwell K, Hamner M. DSM-5-defined attenuated psychosis syndrome and conversion to full-scale schizophrenia spectrum disorders: An institution-wide retrospective review. Ann Clin Psychiatry. 2016 11; 28(4):245-254. PMID: 27490838.
      View in: PubMed
    7. Santa Ana EJ, LaRowe SD, Armeson K, Lamb KE, Hartwell K. Impact of group motivational interviewing on enhancing treatment engagement for homeless Veterans with nicotine dependence and other substance use disorders: A pilot investigation. Am J Addict. 2016 10; 25(7):533-41. PMID: 27589072.
      View in: PubMed
    8. Hartwell KJ, Hanlon CA, Li X, Borckardt JJ, Canterberry M, Prisciandaro JJ, Moran-Santa Maria MM, LeMatty T, George MS, Brady KT. Individualized real-time fMRI neurofeedback to attenuate craving in nicotine-dependent smokers. J Psychiatry Neurosci. 2016 Jan; 41(1):48-55. PMID: 26505139.
      View in: PubMed
    9. McRae-Clark AL, Baker NL, Gray KM, Killeen T, Hartwell KJ, Simonian SJ. Vilazodone for cannabis dependence: A randomized, controlled pilot trial. Am J Addict. 2016 Jan; 25(1):69-75. PMID: 26685701.
      View in: PubMed
    10. Cortese BM, Uhde TW, Brady KT, McClernon FJ, Yang QX, Collins HR, LeMatty T, Hartwell KJ. The fMRI BOLD response to unisensory and multisensory smoking cues in nicotine-dependent adults. Psychiatry Res. 2015 Dec 30; 234(3):321-7. PMID: 26475784.
      View in: PubMed
    11. Saladin ME, McClure EA, Baker NL, Carpenter MJ, Ramakrishnan V, Hartwell KJ, Gray KM. Increasing progesterone levels are associated with smoking abstinence among free-cycling women smokers who receive brief pharmacotherapy. Nicotine Tob Res. 2015 Apr; 17(4):398-406. PMID: 25762749.
      View in: PubMed
    12. Smith PH, Kasza KA, Hyland A, Fong GT, Borland R, Brady K, Carpenter MJ, Hartwell K, Cummings KM, McKee SA. Gender differences in medication use and cigarette smoking cessation: results from the International Tobacco Control Four Country Survey. Nicotine Tob Res. 2015 Apr; 17(4):463-72. PMID: 25762757.
      View in: PubMed
    13. Gray KM, McClure EA, Baker NL, Hartwell KJ, Carpenter MJ, Saladin ME. An exploratory short-term double-blind randomized trial of varenicline versus nicotine patch for smoking cessation in women. Addiction. 2015 Jun; 110(6):1027-34. PMID: 25727442.
      View in: PubMed
    14. Cortese BM, Uhde TW, LaRowe SD, Stein SV, Freeman WC, McClernon FJ, Brady KT, Hartwell KJ. Olfactory cue reactivity in nicotine-dependent adult smokers. Psychol Addict Behav. 2015 Mar; 29(1):91-6. PMID: 25180553.
      View in: PubMed
    15. Hanlon CA, Owens MM, Joseph JE, Zhu X, George MS, Brady KT, Hartwell KJ. Lower subcortical gray matter volume in both younger smokers and established smokers relative to non-smokers. Addict Biol. 2016 Jan; 21(1):185-95. PMID: 25125263.
      View in: PubMed
    16. Moran-Santa Maria MM, Hartwell KJ, Hanlon CA, Canterberry M, Lematty T, Owens M, Brady KT, George MS. Right anterior insula connectivity is important for cue-induced craving in nicotine-dependent smokers. Addict Biol. 2015 Mar; 20(2):407-14. PMID: 24529072.
      View in: PubMed
    17. Canterberry M, Hanlon CA, Hartwell KJ, Li X, Owens M, LeMatty T, Prisciandaro JJ, Borckardt J, Saladin ME, Brady KT, George MS. Sustained reduction of nicotine craving with real-time neurofeedback: exploring the role of severity of dependence. Nicotine Tob Res. 2013 Dec; 15(12):2120-4. PMID: 23935182.
      View in: PubMed
    18. Hanlon CA, Hartwell KJ, Canterberry M, Li X, Owens M, Lematty T, Prisciandaro JJ, Borckardt J, Brady KT, George MS. Reduction of cue-induced craving through realtime neurofeedback in nicotine users: the role of region of interest selection and multiple visits. Psychiatry Res. 2013 Jul 30; 213(1):79-81. PMID: 23683344.
      View in: PubMed
    19. Saladin ME, Gray KM, McRae-Clark AL, Larowe SD, Yeatts SD, Baker NL, Hartwell KJ, Brady KT. A double blind, placebo-controlled study of the effects of post-retrieval propranolol on reconsolidation of memory for craving and cue reactivity in cocaine dependent humans. Psychopharmacology (Berl). 2013 Apr; 226(4):721-37. PMID: 23460266.
      View in: PubMed
    20. Hartwell KJ, Lematty T, McRae-Clark AL, Gray KM, George MS, Brady KT. Resisting the urge to smoke and craving during a smoking quit attempt on varenicline: results from a pilot fMRI study. Am J Drug Alcohol Abuse. 2013 Mar; 39(2):92-8. PMID: 23421569.
      View in: PubMed
    21. Lawson KM, Back SE, Hartwell KJ, Moran-Santa Maria M, Brady KT. A comparison of trauma profiles among individuals with prescription opioid, nicotine, or cocaine dependence. Am J Addict. 2013 Mar-Apr; 22(2):127-31. PMID: 23414497.
      View in: PubMed
    22. Li X, Hartwell KJ, Owens M, Lematty T, Borckardt JJ, Hanlon CA, Brady KT, George MS. Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex reduces nicotine cue craving. Biol Psychiatry. 2013 Apr 15; 73(8):714-20. PMID: 23485014.
      View in: PubMed
    23. Hartwell KJ, Moran-Santa Maria MM, Twal WO, Shaftman S, DeSantis SM, McRae-Clark AL, Brady KT. Association of elevated cytokines with childhood adversity in a sample of healthy adults. J Psychiatr Res. 2013 May; 47(5):604-10. PMID: 23415658.
      View in: PubMed
    24. Brady KT, Haynes LF, Hartwell KJ, Killeen TK. Substance use disorders and anxiety: a treatment challenge for social workers. Soc Work Public Health. 2013; 28(3-4):407-23. PMID: 23731428.
      View in: PubMed
    25. Gray KM, Carpenter MJ, Baker NL, DeSantis SM, Kryway E, Hartwell KJ, McRae-Clark AL, Brady KT. A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents. Am J Psychiatry. 2012 Aug; 169(8):805-12. PMID: 22706327.
      View in: PubMed
    26. Hartwell KJ, Prisciandaro JJ, Borckardt J, Li X, George MS, Brady KT. Real-time fMRI in the treatment of nicotine dependence: a conceptual review and pilot studies. Psychol Addict Behav. 2013 Jun; 27(2):501-9. PMID: 22564200.
      View in: PubMed
    27. Schiller CE, Saladin ME, Gray KM, Hartwell KJ, Carpenter MJ. Association between ovarian hormones and smoking behavior in women. Exp Clin Psychopharmacol. 2012 Aug; 20(4):251-7. PMID: 22545725.
      View in: PubMed
    28. Hanlon CA, Jones EM, Li X, Hartwell KJ, Brady KT, George MS. Individual variability in the locus of prefrontal craving for nicotine: implications for brain stimulation studies and treatments. Drug Alcohol Depend. 2012 Oct 01; 125(3):239-43. PMID: 22459915.
      View in: PubMed
    29. Li X, Hartwell KJ, Borckardt J, Prisciandaro JJ, Saladin ME, Morgan PS, Johnson KA, Lematty T, Brady KT, George MS. Volitional reduction of anterior cingulate cortex activity produces decreased cue craving in smoking cessation: a preliminary real-time fMRI study. Addict Biol. 2013 Jul; 18(4):739-48. PMID: 22458676.
      View in: PubMed
    30. Hartwell KJ, Back SE, McRae-Clark AL, Shaftman SR, Brady KT. Motives for using: a comparison of prescription opioid, marijuana and cocaine dependent individuals. Addict Behav. 2012 Apr; 37(4):373-8. PMID: 22284583.
      View in: PubMed
    31. Hartwell KJ, Johnson KA, Li X, Myrick H, LeMatty T, George MS, Brady KT. Neural correlates of craving and resisting craving for tobacco in nicotine dependent smokers. Addict Biol. 2011 Oct; 16(4):654-66. PMID: 21790899.
      View in: PubMed
    32. Prisciandaro JJ, McRae-Clark AL, Moran-Santa Maria MM, Hartwell KJ, Brady KT. Psychoticism and neuroticism predict cocaine dependence and future cocaine use via different mechanisms. Drug Alcohol Depend. 2011 Jul 01; 116(1-3):80-5. PMID: 21306838.
      View in: PubMed
    33. Johnson KA, Hartwell K, LeMatty T, Borckardt J, Morgan PS, Govindarajan K, Brady K, George MS. Intermittent "real-time" fMRI feedback is superior to continuous presentation for a motor imagery task: a pilot study. J Neuroimaging. 2012 Jan; 22(1):58-66. PMID: 20977537.
      View in: PubMed
    34. Gray KM, Carpenter MJ, Baker NL, Hartwell KJ, Lewis AL, Hiott DW, Deas D, Upadhyaya HP. Bupropion SR and contingency management for adolescent smoking cessation. J Subst Abuse Treat. 2011 Jan; 40(1):77-86. PMID: 20934835.
      View in: PubMed
    35. McRae-Clark AL, Brady KT, Hartwell KJ, White K, Carter RE. Methylphenidate transdermal system in adults with past stimulant misuse: an open-label trial. J Atten Disord. 2011 Oct; 15(7):539-44. PMID: 20538968.
      View in: PubMed
    36. Back SE, Hartwell K, DeSantis SM, Saladin M, McRae-Clark AL, Price KL, Moran-Santa Maria MM, Baker NL, Spratt E, Kreek MJ, Brady KT. Reactivity to laboratory stress provocation predicts relapse to cocaine. Drug Alcohol Depend. 2010 Jan 01; 106(1):21-7. PMID: 19726138.
      View in: PubMed
    37. Hartwell KJ, Tolliver BK, Brady KT. Biologic Commonalities between Mental Illness and Addiction. Prim psychiatry. 2009 Aug 01; 16(8):33-39. PMID: 26030747.
      View in: PubMed
    38. Payne RA, Back SE, Wright T, Hartwell K, Brady KT. Alcohol dependence in women: Comorbidities can complicate treatment. Curr Psychiatr. 2009 Jun 01; 8(6):52-59. PMID: 20676219.
      View in: PubMed
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