Last Name

Karen J. Hartwell

InstitutionMedical University of South Carolina
DepartmentPsychiatry and Behavioral Sciences
AddressP.O. Box MSC 861
Suite 140
125 Doughty St.
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    Dr. Hartwell's general research interests are tobacco use disorders, smoking cessation and craving to smoke during a quit attempt. Her studies have examined the underlying neurobiology of craving using neuroimaging techniques. She is also interested in gender differences in substance use disorders. As an addiction psychiatrist she provides clinical care for substance use disorders at the Ralph H. Johnson VAMC.

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    smoking cessation, tobacco use disorders, substance use disorder treatment

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Chauchard E, Hartwell KJ, McRae-Clark AL, Sherman BJ, Gorelick DA. Cannabis Withdrawal in Adults With Attention-Deficit/Hyperactivity Disorder. Prim Care Companion CNS Disord. 2018 Feb 22; 20(1). PMID: 29489073.
      View in: PubMed
    2. Li X, Sahlem GL, Badran BW, McTeague LM, Hanlon CA, Hartwell KJ, Henderson S, George MS. Transcranial magnetic stimulation of the dorsal lateral prefrontal cortex inhibits medial orbitofrontal activity in smokers. Am J Addict. 2017 Dec; 26(8):788-794. PMID: 28898485.
      View in: PubMed
    3. Moran-Santa Maria MM, Vanderweyen D, Camp C, Zhu X, McKee SA, Cosgrove KP, Hartwell KJ, Brady KT, Joseph JE. Network analysis of intrinsic functional brain connectivity in male and female adult smokers: A Preliminary Study. Nicotine Tob Res. 2017 Sep 09. PMID: 29059410.
      View in: PubMed
    4. Zuschlag Z, Kennedy A, Korte J, Franko-Tobin L, Hartwell K, Hamner M. DSM-5-defined attenuated psychosis syndrome and conversion to full-scale schizophrenia spectrum disorders: An institution-wide retrospective review. Ann Clin Psychiatry. 2016 Nov; 28(4):245-254. PMID: 27490838.
      View in: PubMed
    5. Santa Ana EJ, LaRowe SD, Armeson K, Lamb KE, Hartwell K. Impact of group motivational interviewing on enhancing treatment engagement for homeless Veterans with nicotine dependence and other substance use disorders: A pilot investigation. Am J Addict. 2016 Oct; 25(7):533-41. PMID: 27589072.
      View in: PubMed
    6. Hartwell KJ, Hanlon CA, Li X, Borckardt JJ, Canterberry M, Prisciandaro JJ, Moran-Santa Maria MM, LeMatty T, George MS, Brady KT. Individualized real-time fMRI neurofeedback to attenuate craving in nicotine-dependent smokers. J Psychiatry Neurosci. 2016 Jan; 41(1):48-55. PMID: 26505139; PMCID: PMC4688028.
    7. McRae-Clark AL, Baker NL, Gray KM, Killeen T, Hartwell KJ, Simonian SJ. Vilazodone for cannabis dependence: A randomized, controlled pilot trial. Am J Addict. 2016 Jan; 25(1):69-75. PMID: 26685701; PMCID: PMC4937726 [Available on 01/01/17].
    8. Cortese BM, Uhde TW, Brady KT, McClernon FJ, Yang QX, Collins HR, LeMatty T, Hartwell KJ. The fMRI BOLD response to unisensory and multisensory smoking cues in nicotine-dependent adults. Psychiatry Res. 2015 Dec 30; 234(3):321-7. PMID: 26475784.
      View in: PubMed
    9. Saladin ME, McClure EA, Baker NL, Carpenter MJ, Ramakrishnan V, Hartwell KJ, Gray KM. Increasing progesterone levels are associated with smoking abstinence among free-cycling women smokers who receive brief pharmacotherapy. Nicotine Tob Res. 2015 Apr; 17(4):398-406. PMID: 25762749; PMCID: PMC4432400.
    10. Smith PH, Kasza KA, Hyland A, Fong GT, Borland R, Brady K, Carpenter MJ, Hartwell K, Cummings KM, McKee SA. Gender differences in medication use and cigarette smoking cessation: results from the International Tobacco Control Four Country Survey. Nicotine Tob Res. 2015 Apr; 17(4):463-72. PMID: 25762757; PMCID: PMC4402353.
    11. Gray KM, McClure EA, Baker NL, Hartwell KJ, Carpenter MJ, Saladin ME. An exploratory short-term double-blind randomized trial of varenicline versus nicotine patch for smoking cessation in women. Addiction. 2015 Jun; 110(6):1027-34. PMID: 25727442; PMCID: PMC4430389.
    12. Cortese BM, Uhde TW, LaRowe SD, Stein SV, Freeman WC, McClernon FJ, Brady KT, Hartwell KJ. Olfactory cue reactivity in nicotine-dependent adult smokers. Psychol Addict Behav. 2015 Mar; 29(1):91-6. PMID: 25180553; PMCID: PMC4345131.
    13. Hanlon CA, Owens MM, Joseph JE, Zhu X, George MS, Brady KT, Hartwell KJ. Lower subcortical gray matter volume in both younger smokers and established smokers relative to non-smokers. Addict Biol. 2016 Jan; 21(1):185-95. PMID: 25125263; PMCID: PMC4326619 [Available on 01/01/17].
    14. Moran-Santa Maria MM, Hartwell KJ, Hanlon CA, Canterberry M, Lematty T, Owens M, Brady KT, George MS. Right anterior insula connectivity is important for cue-induced craving in nicotine-dependent smokers. Addict Biol. 2015 Mar; 20(2):407-14. PMID: 24529072; PMCID: PMC4133311.
    15. Canterberry M, Hanlon CA, Hartwell KJ, Li X, Owens M, LeMatty T, Prisciandaro JJ, Borckardt J, Saladin ME, Brady KT, George MS. Sustained reduction of nicotine craving with real-time neurofeedback: exploring the role of severity of dependence. Nicotine Tob Res. 2013 Dec; 15(12):2120-4. PMID: 23935182; PMCID: PMC3819983.
    16. Hanlon CA, Hartwell KJ, Canterberry M, Li X, Owens M, Lematty T, Prisciandaro JJ, Borckardt J, Brady KT, George MS. Reduction of cue-induced craving through realtime neurofeedback in nicotine users: the role of region of interest selection and multiple visits. Psychiatry Res. 2013 Jul 30; 213(1):79-81. PMID: 23683344; PMCID: PMC4093788.
    17. Saladin ME, Gray KM, McRae-Clark AL, Larowe SD, Yeatts SD, Baker NL, Hartwell KJ, Brady KT. A double blind, placebo-controlled study of the effects of post-retrieval propranolol on reconsolidation of memory for craving and cue reactivity in cocaine dependent humans. Psychopharmacology (Berl). 2013 Apr; 226(4):721-37. PMID: 23460266; PMCID: PMC3637960.
    18. Hartwell KJ, Lematty T, McRae-Clark AL, Gray KM, George MS, Brady KT. Resisting the urge to smoke and craving during a smoking quit attempt on varenicline: results from a pilot fMRI study. Am J Drug Alcohol Abuse. 2013 Mar; 39(2):92-8. PMID: 23421569; PMCID: PMC4501024.
    19. Lawson KM, Back SE, Hartwell KJ, Moran-Santa Maria M, Brady KT. A comparison of trauma profiles among individuals with prescription opioid, nicotine, or cocaine dependence. Am J Addict. 2013 Mar-Apr; 22(2):127-31. PMID: 23414497; PMCID: PMC3681508.
    20. Li X, Hartwell KJ, Owens M, Lematty T, Borckardt JJ, Hanlon CA, Brady KT, George MS. Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex reduces nicotine cue craving. Biol Psychiatry. 2013 Apr 15; 73(8):714-20. PMID: 23485014; PMCID: PMC3615051.
    21. Hartwell KJ, Moran-Santa Maria MM, Twal WO, Shaftman S, DeSantis SM, McRae-Clark AL, Brady KT. Association of elevated cytokines with childhood adversity in a sample of healthy adults. J Psychiatr Res. 2013 May; 47(5):604-10. PMID: 23415658; PMCID: PMC3594625.
    22. Brady KT, Haynes LF, Hartwell KJ, Killeen TK. Substance use disorders and anxiety: a treatment challenge for social workers. Soc Work Public Health. 2013; 28(3-4):407-23. PMID: 23731428; PMCID: PMC3775646.
    23. Gray KM, Carpenter MJ, Baker NL, DeSantis SM, Kryway E, Hartwell KJ, McRae-Clark AL, Brady KT. A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents. Am J Psychiatry. 2012 Aug; 169(8):805-12. PMID: 22706327; PMCID: PMC3410961.
    24. Hartwell KJ, Prisciandaro JJ, Borckardt J, Li X, George MS, Brady KT. Real-time fMRI in the treatment of nicotine dependence: a conceptual review and pilot studies. Psychol Addict Behav. 2013 Jun; 27(2):501-9. PMID: 22564200; PMCID: PMC3646943.
    25. Schiller CE, Saladin ME, Gray KM, Hartwell KJ, Carpenter MJ. Association between ovarian hormones and smoking behavior in women. Exp Clin Psychopharmacol. 2012 Aug; 20(4):251-7. PMID: 22545725; PMCID: PMC3660106.
    26. Hanlon CA, Jones EM, Li X, Hartwell KJ, Brady KT, George MS. Individual variability in the locus of prefrontal craving for nicotine: implications for brain stimulation studies and treatments. Drug Alcohol Depend. 2012 Oct 01; 125(3):239-43. PMID: 22459915.
      View in: PubMed
    27. Li X, Hartwell KJ, Borckardt J, Prisciandaro JJ, Saladin ME, Morgan PS, Johnson KA, Lematty T, Brady KT, George MS. Volitional reduction of anterior cingulate cortex activity produces decreased cue craving in smoking cessation: a preliminary real-time fMRI study. Addict Biol. 2013 Jul; 18(4):739-48. PMID: 22458676; PMCID: PMC3389595.
    28. Hartwell KJ, Back SE, McRae-Clark AL, Shaftman SR, Brady KT. Motives for using: a comparison of prescription opioid, marijuana and cocaine dependent individuals. Addict Behav. 2012 Apr; 37(4):373-8. PMID: 22284583; PMCID: PMC3288828.
    29. Hartwell KJ, Johnson KA, Li X, Myrick H, LeMatty T, George MS, Brady KT. Neural correlates of craving and resisting craving for tobacco in nicotine dependent smokers. Addict Biol. 2011 Oct; 16(4):654-66. PMID: 21790899; PMCID: PMC3182826.
    30. Prisciandaro JJ, McRae-Clark AL, Moran-Santa Maria MM, Hartwell KJ, Brady KT. Psychoticism and neuroticism predict cocaine dependence and future cocaine use via different mechanisms. Drug Alcohol Depend. 2011 Jul 01; 116(1-3):80-5. PMID: 21306838; PMCID: PMC3105212.
    31. Johnson KA, Hartwell K, LeMatty T, Borckardt J, Morgan PS, Govindarajan K, Brady K, George MS. Intermittent "real-time" fMRI feedback is superior to continuous presentation for a motor imagery task: a pilot study. J Neuroimaging. 2012 Jan; 22(1):58-66. PMID: 20977537; PMCID: PMC3070198.
    32. Gray KM, Carpenter MJ, Baker NL, Hartwell KJ, Lewis AL, Hiott DW, Deas D, Upadhyaya HP. Bupropion SR and contingency management for adolescent smoking cessation. J Subst Abuse Treat. 2011 Jan; 40(1):77-86. PMID: 20934835; PMCID: PMC2997899.
    33. McRae-Clark AL, Brady KT, Hartwell KJ, White K, Carter RE. Methylphenidate transdermal system in adults with past stimulant misuse: an open-label trial. J Atten Disord. 2011 Oct; 15(7):539-44. PMID: 20538968; PMCID: PMC3603563.
    34. Back SE, Hartwell K, DeSantis SM, Saladin M, McRae-Clark AL, Price KL, Moran-Santa Maria MM, Baker NL, Spratt E, Kreek MJ, Brady KT. Reactivity to laboratory stress provocation predicts relapse to cocaine. Drug Alcohol Depend. 2010 Jan 01; 106(1):21-7. PMID: 19726138; PMCID: PMC2815094.
    35. Hartwell KJ, Tolliver BK, Brady KT. Biologic Commonalities between Mental Illness and Addiction. Prim psychiatry. 2009 Aug 01; 16(8):33-39. PMID: 26030747.
      View in: PubMed
    36. Payne RA, Back SE, Wright T, Hartwell K, Brady KT. Alcohol dependence in women: Comorbidities can complicate treatment. Curr Psychiatr. 2009 Jun 01; 8(6):52-59. PMID: 20676219.
      View in: PubMed
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